CN105797119A - Traditional Chinese medicine composition for treating chronic gastritis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating chronic gastritis and preparation method thereof Download PDF

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CN105797119A
CN105797119A CN201610285778.0A CN201610285778A CN105797119A CN 105797119 A CN105797119 A CN 105797119A CN 201610285778 A CN201610285778 A CN 201610285778A CN 105797119 A CN105797119 A CN 105797119A
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parts
chinese medicine
herba
radix
semen
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刘春梅
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic gastritis. The traditional Chinese medicine composition consists of the following components in parts by weight: 6-12 parts of rhizoma corydalis, 6-12 parts of fructus amomi, 6-12 parts of radix astragali, 6-15 parts of wrinkled gianthyssop herb, 9-18 parts of fructus crataegi, 6-18 parts of endothelium corneum gigeriae galli, 10-20 parts of ginger, 5-15 parts of rhizoma cyperi, 3-9 parts of piper longum, 3-9 parts of fructus evodiae, 3-9 parts of alpinia katsumadai, 3-9 parts of mangnolia officinalis, 2-6 parts of codonopsis pilosula, 2-8 parts of concha arcae, 3-12 parts of endoconcha sepiae, 3-15 parts of coptis chinensis, 9-18 parts of semen raphani, 9-18 parts of flos inulae, 3-12 parts of pseudo-ginseng, 6-18 parts of pumpkin flower, 6-18 parts of herba artemisiae capillariae, 3-15 parts of cyclea racemosa oliv., 3-18 parts of dandelion, 3-18 parts of hedyotis diffusa, 3-12 parts of cassia seed, 3-12 parts of dendrobium compactum, 3-12 parts of mallotus apelta root, 3-12 parts of peach kernel, 6-18 parts of coix seed, 6-18 parts of radix acanthopanacis semticosi and 5-15 parts of green tangerine peel. The invention also discloses a preparation method of the traditional Chinese medicine composition.

Description

A kind of Chinese medicine composition treating chronic gastritis and preparation method
Technical field
The present invention relates to a kind of Chinese medicine preparation, a kind of Chinese medicine composition treating chronic gastritis and preparation method thereof.
Background technology
Chronic gastritis means the various chronic gastric mucosa inflammatory lesion that different pathogeny causes, and is a kind of commonly encountered diseases, and its sickness rate is respectively Plant in gastropathy and rank first.Fiberendoscope has recognized since extensively applying and is significantly improved.Common type has chronic superficial gastritis, slow Property erosive gastritis and chronic atrophic gastritis.Etiological may have: helicobacter pylori infections, virus or its toxin, common After acute gastritis, gastric mucosal lesions is prolonged does not more develop into chronic superficial gastritis.Pungent, long-term drink is strong The pungents such as wine, strong tea, espresso destroy gastric mucosal protection barrier and gastritis occur.Some medicine such as Phenylbutazone, antiinflammatory Bitterly, cinchophen and salicylate, Folium Digitalis Purpureae etc. can cause chronic Gastric mucosal lesion.Bile reflux, the cholate contained in bile can Destroy gastric mucosal barrier, make the hydrion back diffusion in gastric juice enter gastric mucosa and cause inflammation.Environmental change, as environment changes, Climate change, if people can not adapt at short notice, so that it may causes the nervous dysfunction of domination stomach, just gastric secretion stomach function regulating Move inharmonious, produce gastritis.Also have long-term psychentonia, live irregular, and the impact of other pathological changes, as uremia, Ulcerative colitiss etc. all can cause chronic gastritis.
The weight of chronic gastritis symptom and the lesion degree of gastric mucosa are the most non-uniform.Most patient is the most asymptomatic or has degree different Indigestion symptom such as upper abdomen dull pain, loss of appetite, post-prandial fullness, acid regurgitation etc..Chronic Atrophic Gastritis Patients can have anemia, Become thin, glossitis, diarrhoea etc., person's upper abdominal pain that individuals patients accompanies mucosal erosion is more apparent, and can have hemorrhage, such as hematemesis, melena. Symptom usually recurrent exerbation, irregularities suffers from abdominal pain, and pain often arises in feeding process or after the meal, majority be positioned at epigastrium, Umbilicus week, some patients position are not fixed, and the lighter's intermittence dull pain or dull pain, severe patient are violent angor.
Major part chronic superficial gastritis reversible, small part can transfer chronic atrophic gastritis to.Chronic atrophy gastritis with the age by Gradually increase the weight of, but mild also reversible.Therefore, chronic gastritis treatment should be withered to chronic early from the beginning of chronic superficial gastritis Contracting gastritis also should adhere to treatment.Use treatment with western more at present, atropine, probanthine, top during panic attacks, can be used Eggplant mixture etc..Gastric hyperacidity can use PPI proton pump inhibitor such as rabeprazole, lansoprazole, omeprazole etc., and symptom is lighter Person can use H2 receptor blocking agent such as cimetidine, ranitidine, aluminium hydroxide amine etc..Achlorhydria or anacidity person can give 1% Dilute hydrochloric acid or Pepsin Mixture, can add with the digestant such as pancreatin tablets, polyzyme tablets with dyspepsia person.Gastric mucosa biopsy is sent out Existing helicobacter pylori person adds antibiotic therapy.The obvious person of bile reflux can with metoclopramide and motilium to strengthen stomach antral peristasis, Reduce bile reflux.Hydrotalcite tablet, cholestyramine, sucralfate can be combined with bile acid, mitigation symptoms.
But owing to various factors affects, the patient of the gastrointestinal dysfunction such as nausea and vomiting, abdominal pain and distension occurs increasingly after western medical treatment Increase.A lot of people can produce various ill symptoms, such as irritable bowel syndrome, irritable bowel syndrome master doing early enteron feeding Diarrhea-type to be divided into, constipation type two kinds, constipation type irritable bowel syndrome mainly shows as being hard and dry, when thinking just, slow solution not under, Abdominal part swelling pain, intestinal cramps, diarrhea irritable bowel syndrome then shows as defecating dilute, one day defecation more than three times, sometimes, Oneself does not controls.At present, the pathogenesis of chronic gastritis and associated conditions thereof is not fully understood, owing to pathogenesis is complicated, Western medicine side effect is stronger, it is impossible to fully meet the needs of extensive patients.And Chinese medicine is from organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Certainly, side effect is little, treatment cost economy, has good development prospect for curative effect.
Long-term taking Western medicine can produce irritability stasis at present, the situations such as Rong Wei is obstructed.Having research data to confirm, Chinese medicine can not only be controlled Treat and improve gastropathy, strengthen the metabolic capacity of health, and while treatment, moreover it is possible to disorderly digestive function is adjusted, Treatment can be cured for a long time, and relapse rate is low.
Summary of the invention
The present invention mainly solves the technical problem in the presence of prior art, thus provides one to be specifically designed for chronic gastritis and carry out The medicine for the treatment of, is aided with the special medicinal material that Recent study shows to have significant curative effect simultaneously, and the Chinese medicine composition allocated. Said composition can either be individually used for treatment, it is also possible to during coordinating western medicine, alleviates and removes Western medicine to patient's body The side effect that body causes.
The above-mentioned technical problem of the present invention is mainly addressed by following technical proposals:
A kind of Chinese medicine composition treating chronic gastritis, it is characterised in that: described Chinese medicine composition is each by following weight parts proportioning Component forms: Rhizoma Corydalis 6-12 part, Fructus Amomi 6-12 part, Herba Pogostemonis 6-15 part, Fructus Crataegi 9-18 part, Endothelium Corneum Gigeriae Galli 6-18 part, Rhizoma Zingiberis Recens 10-20 part, Rhizoma Cyperi 5-15 part, Piper longum 3-9 part, Fructus Evodiae 3-9 part, Semen Alpiniae Katsumadai 3-9 part, Cortex Magnoliae Officinalis 3-9 part, Radix Codonopsis 2-6 Part, Concha Arcae 2-8 part, sea Piao sheath 3-12 part, Rhizoma Coptidis 3-15 part, Semen Raphani 9-18 part, Radix Astragali 6-12 part, honey Flos Inulae Flower 9-18 part, Radix Notoginseng 3-12 part, Flos Cucurbitae 6-18 part, Herba Artemisiae Scopariae 6-18 part, good rattan 3-15 part, Herba Taraxaci 3-18 part, Herba Hedyotidis Diffusae 3-18 part, Semen Cassiae 3-12 part, grass Herba Dendrobii 3-12 part, Semen Coicis 6-18 part, wild Radix paulowniae 3-12 part, thorn Slender acanthopanax 6-18 part, Pericarpium Citri Reticulatae Viride 5-15 part, Semen Persicae 3-12 part.
Further, described Chinese medicine composition is made up of each component of following weight parts proportioning: Rhizoma Corydalis 9-12 part, Fructus Amomi 6-9 part, Herba Pogostemonis 6-12 part, Fructus Crataegi 12-18 part, Endothelium Corneum Gigeriae Galli 6-10 part, Rhizoma Zingiberis Recens 10-15 part, Rhizoma Cyperi 5-10 part, Piper longum 3-6 part, Fructus Evodiae 6-9 part, Semen Alpiniae Katsumadai 5-9 part, Cortex Magnoliae Officinalis 6-9 part, Radix Codonopsis 4-6 part, Concha Arcae 5-8 part, sea Piao sheath 6-12 part, Rhizoma Coptidis 9-15 part, Semen Raphani 12-18 part, Radix Astragali 9-12 part, honey Flos Inulae 12-18 part, Radix Notoginseng 6-12 part, Flos Cucurbitae 9-18 part, Herba Artemisiae Scopariae 12-18 part, good rattan 9-15 part, Herba Taraxaci 9-18 part, Herba Hedyotidis Diffusae 9-18 part, Semen Cassiae 9-12 Part, grass Herba Dendrobii 6-12 part, Semen Coicis 12-18 part, wild Radix paulowniae 6-12 part, Radix Et Caulis Acanthopanacis Senticosi 9-18 part, Pericarpium Citri Reticulatae Viride 9-15 part, Fructus Persicae Core 8-12 part.
Further, described Chinese medicine composition is made up of each component of following weight parts proportioning: Rhizoma Corydalis 10 parts, Fructus Amomi 6 parts, the leaves of pulse plants Perfume 8 parts, Fructus Crataegi 14 parts, Endothelium Corneum Gigeriae Galli 7 parts, 12 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 6 parts, Piper longum 4 parts, Fructus Evodiae 8 parts, Semen Alpiniae Katsumadai 6 parts, Cortex Magnoliae Officinalis 6 parts, Radix Codonopsis 4 parts, Concha Arcae 6 parts, sea 8 parts of Piao sheath, Rhizoma Coptidis 9 parts, Semen Raphani 12 parts, the Radix Astragali 9 parts, Honey Flos Inulae 12 parts, Radix Notoginseng 8 parts, Flos Cucurbitae 9 parts, Herba Artemisiae Scopariae 12 parts, 10 parts of good rattan, Herba Taraxaci 10 parts, Herba Hedyotidis Diffusae Grass 10 parts, Semen Cassiae 9 parts, grass Herba Dendrobii 6 parts, Semen Coicis 12 parts, wild Radix paulowniae 6 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, 10 parts of Pericarpium Citri Reticulatae Viride, 10 parts of Semen Persicae.Or described Chinese medicine composition is made up of each component of following weight parts proportioning: Rhizoma Corydalis 12 parts, Fructus Amomi 9 parts, Herba Pogostemonis 10 parts, Fructus Crataegi 16 parts, Endothelium Corneum Gigeriae Galli 10 parts, 15 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 10 parts, Piper longum 6 parts, Fructus Evodiae 9 parts, grass 8 parts of Fructus Amomi Rotundus, Cortex Magnoliae Officinalis 9 parts, Radix Codonopsis 6 parts, Concha Arcae 8 parts, 12 parts of the Piao sheath in sea, Rhizoma Coptidis 14 parts, Semen Raphani 16 parts, Huang Stilbene 11 parts, honey Flos Inulae 18 parts, Radix Notoginseng 10 parts, Flos Cucurbitae 15 parts, Herba Artemisiae Scopariae 15 parts, 14 parts of good rattan, Herba Taraxaci 15 parts, Herba Hedyotidis Diffusae 16 parts, Semen Cassiae 12 parts, grass Herba Dendrobii 12 parts, Semen Coicis 18 parts, wild Radix paulowniae 12 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 15 parts of Pericarpium Citri Reticulatae Viride, 12 parts of Semen Persicae.
The preparation method of a kind of Chinese medicine composition for the treatment of chronic gastritis is also claimed, chooses foregoing weight Traditional Chinese medicine composite, and follow the steps below and be prepared from:
1) processing of medical material step: calcine: the uncovered calcine of Concha Arcae heatproof container, pulverizes standby；Processed with vinegar: take and totally dry Rhizoma Corydalis, according to stir-baking with vinegar fried dry, smashs to pieces standby；Salt system: take the Fructus Amomi totally dried, adds saline and mixes thoroughly, the most vexed, treats saline After being sucked, putting in parch container, heat with slow fire, fried dry, taking-up is dried in the air cool, smashs to pieces standby；Parch: Semen Raphani, Rhizoma Cyperi, Sea Piao sheath, Semen Coicis clean rear parch, pulverize；Yellow wine system:: take Fructus Piperis Longi clean dry, every 50 grams add 400 milliliters of yellow wine Middle immersion 7 days, removes nature and dries, pulverize；Chopping: by Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae Flower, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae, remove residual Root and impurity, pick clean impurity, the destemming leaf that takes, sieve dedusting bits, clean chopping；Processed with honey: the Radix Astragali, Fructus Evodiae, Cortex Magnoliae Officinalis, Radix Codonopsis.
2) calcine of step (1), processed with vinegar, salt system, parch, yellow wine system, the medical material co-grinding of processed with honey gained are crossed 120-200 Mesh sieve, mixes by weight, obtains former powder A, and stirs with ultra violet lamp sterilization or use co-60 radiation sterilizing 30-60min, co-60 radiation sterilizing dose 1-3Kgy.
Aforementioned calcine, processed with vinegar, salt system, parch, yellow wine system, the medical material of processed with honey be all applicant through repeatedly contrast experiment, grind The method of the optimum performance drug effect studied carefully and find out, and Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae medical material, Jing Guochuan System concocting method is concocted, it has been investigated that the loss of ketone therein, aldehydes matter is more serious, and these are all to treat chronic stomach Scorching important effective ingredient, so the application is used raw pharmacy liquid to utilize, and utilizes the method for similar pasteurize to ensure Antibacterial therein is effectively killed, and ensures the healthy attribute of medicinal liquid with this.
3) by the former powder A after sterilizing, distilled water reflux, extract, containing 20-70% ethanol is added 3-5 time, every time by the second of 3-5 times amount Alcohol reflux extracts 0.5-1.5 hour, filters united extraction liquid, and reclaims ethanol, is concentrated into relative density 1.05-1.45, adds Entering 75% appropriate amount of ethanol, make medicinal liquid alcohol content promote 0.5-1 times, limit edged is sufficiently stirred for, and stands 12-24h, filters, and reclaims Ethanol to without alcohol taste, obtains clear paste, then adds DDW extremely containing crude drug 0.5-2g/ml, and medicinal liquid adds percentage by weight 1-3% activated carbon, After heated and boiled, cooling, stand at low temperature 6-12h after filtration, obtain water-soluble medicine soup, filter off medicinal residues and obtain fried medicinal liquid.
4) the chopping medical material of step (1) is squeezed into juice, and mixes to obtain raw pharmacy liquid, life pharmacy liquid is heated to 60～75 DEG C, And it is cooled to 5 DEG C rapidly after keeping this temperature 30-60min.
5) the raw pharmacy liquid of aforementioned for step (3) gained fried medicinal liquid and step (4) gained is mixed, be filtered to remove medicine further Slag, slow evaporation concentrates becomes thickness ointment, obtains described Chinese medicine composition.
The preparation method of the Chinese medicine composition of aforementioned therapies chronic gastritis, it is characterised in that: be previously mentioned clean, refer to Repeatedly wash with distilled water；After aforementioned fried medicinal liquid and raw pharmacy liquid are mixed by described step (5), then carry out multiple times of filtration with fully Ground removes medicinal residues, then is evaporated concentrating, and is properly added adjuvant in evaporating concentration process, at residual moisture at 3%-6% Between time, carry out the preparation of tablet by the mode of mechanical presses, under extraordinary air flow communication, carry out humidity strip be dried, Being dried 3-7 days at 15-25 DEG C, sampling 0.5-1.5% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
The manufacture method of tablet can also is that as follows: after aforementioned fried medicinal liquid and raw pharmacy liquid are mixed by described step (5), then enters Row multiple times of filtration is to remove medicinal residues fully, then is evaporated concentrating, and adds the cross-linked methyl sodium cellulosate of 3%-10%, wet method system Grain, slowly dries, and adds appropriate magnesium stearate to being easy to the dosage of tabletting, is then compressed to tablet.
The processing mode of the former powder A of abovementioned steps (3), can be replaced by following: add medicine gross mass 5-10 times quality Mass concentration is the ethanol water of 75%, is then refluxed for extracting 3 times, each 1 hour, and united extraction liquid also cools down 60-90min, Again through 2-3 16 layers of filtered through gauze, obtain first-time filtrate.Filtering residue after filtering is merged, same addition filtering residue gross mass 5-10 The ethanol water that mass concentration is 75% of times quality, is then refluxed for extracting 3 times, each 1 hour, and united extraction liquid is the coldest But 60-90min, then through 2-3 16 layers of filtered through gauze, obtain secondary filtrate, first-time filtrate and secondary filtrate are merged, subtracts Pushing back receipts ethanol, be concentrated into without alcohol taste, then proceed in evaporating dish, 50-55 DEG C of heating in water bath is evaporated.
Further, aforementioned after aforementioned fried medicinal liquid and the mixing of raw pharmacy liquid, multiple times of filtration is carried out again to remove medicinal residues fully Step, according to circumstances chooses, if fried medicinal liquid and raw pharmacy liquid are all without any medicinal residues, does not also produce precipitation etc. after mixing, Then without carrying out, if still occurring in that precipitation or floccule, then this step can be carried out.That adds in evaporation and concentration is auxiliary Expecting such as fructose, crystal sugar, Mel, starch, cyclodextrin etc., contributing to cover or offset Chinese medicine bitter taste is the common auxiliary of master Material.
Compared with prior art, it is an advantage of the current invention that: can effectively treat and improve chronic gastritis.Said composition can Enough it is individually used for treating chronic gastritis, it is also possible to during coordinating western medicine, alleviate and remove Western medicine and patient body is made The side effect become.
Part primary raw material curative effect: Rhizoma Corydalis, Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis, for Papaveraceae Corydalis herbaceos perennial, For the pain relieving good medicine in Chinese medicine, having a pain gastral cavilty and victory is particularly imitated in abdominal pain during menstruation, compatibility application is better.Fructus Amomi, Fructus Amomi has Removing dampness is had to whet the appetite, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels.
Herba Pogostemonis, Herba Pogostemonis has pleasant, and in, ward off dirty, effect of damp eliminating.Cure cold heat-damp in summer, cold and heat, headache, and breast gastral cavity painful abdominal mass is vexed, Vomiting is had loose bowels, malaria, dysentery, halitosis.Fructus Crataegi, Fructus Crataegi has promoting digestion and removing stagnation, effect of circulation of qi promoting dissipating blood stasis.Digest for gastropathy The eating accumulation that hypofunction causes can use.Endothelium Corneum Gigeriae Galli, this product has stronger promoting digestion and removing stagnation effect, and can be good for fortune Taste, are widely used in the various dyspepsias for the treatment of rice and flour potato meat stagnation.Pathogenic cold stomach invading type, in cold-evil, visitor is in stomach, stomach sun Being held back by cold-evil and must not unfold, mechanism of qi blocks, and clinical manifestation is made for stomachache is sudden and violent, and aversion to cold and preference for warmth obtains warm alleviation of pain, desire for hot drinks, Thin white fur of tongue, stringy and tense pulse etc..
Detailed description of the invention
Below the preferred embodiments of the present invention are described in detail, so that advantages and features of the invention can be easier to by this area Artisans understand that, thus protection scope of the present invention is made apparent clear and definite defining.
Embodiment 1
A kind of Chinese medicine composition treating chronic gastritis, it is characterised in that: described Chinese medicine composition is each by following weight parts proportioning Component forms: Rhizoma Corydalis 10 parts, Fructus Amomi 6 parts, Herba Pogostemonis 8 parts, Fructus Crataegi 14 parts, Endothelium Corneum Gigeriae Galli 7 parts, 12 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 6 Part, Piper longum 4 parts, Fructus Evodiae 8 parts, Semen Alpiniae Katsumadai 6 parts, Cortex Magnoliae Officinalis 6 parts, Radix Codonopsis 4 parts, Concha Arcae 6 parts, sea 8 parts of Piao sheath, Rhizoma Coptidis 9 parts, Semen Raphani 12 parts, the Radix Astragali 9 parts, honey Flos Inulae 12 parts, Radix Notoginseng 8 parts, Flos Cucurbitae 9 parts, Herba Artemisiae Scopariae 12 parts, 10 parts of good rattan, Herba Taraxaci 10 parts, Herba Hedyotidis Diffusae 10 parts, Semen Cassiae 9 parts, grass Herba Dendrobii 6 parts, Semen Coicis 12 parts, open country Radix paulowniae 6 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, 10 parts of Pericarpium Citri Reticulatae Viride, 10 parts of Semen Persicae.
Protect the preparation method of a kind of Chinese medicine composition treating chronic gastritis, choose the Chinese drug-treated group of foregoing weight Compound raw material, and follow the steps below and be prepared from:
1) processing of medical material step: calcine: the uncovered calcine of Concha Arcae heatproof container, shreds standby；Processed with vinegar: take and totally dry Rhizoma Corydalis, according to stir-baking with vinegar fried dry, smashs to pieces standby；Salt system: take the Fructus Amomi totally dried, adds saline and mixes thoroughly, the most vexed, treats saline After being sucked, putting in parch container, heat with slow fire, fried dry, taking-up is dried in the air cool, smashs to pieces standby；Parch: Semen Raphani, Rhizoma Cyperi, Sea Piao sheath, Semen Coicis clean rear parch, chopping；Yellow wine system:: take Fructus Piperis Longi clean dry, every 50 grams add 400 milliliters of yellow wine Middle immersion 7 days, removes nature and dries, chopping；Chopping: by Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae Flower, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae, remove residual Root and impurity, pick clean impurity, the destemming leaf that takes, sieve dedusting bits, clean chopping；Processed with honey: the Radix Astragali, Fructus Evodiae, Cortex Magnoliae Officinalis, Radix Codonopsis.
2) calcine of step (1), processed with vinegar, salt system, parch, yellow wine system, the medical material co-grinding of processed with honey gained are crossed 120 Mesh sieve, mixes by weight, obtains former powder A, and stirs with ultra violet lamp sterilization or use co-60 radiation sterilizing 30-60min, co-60 radiation sterilizing dose 1-3Kgy.
3) by the former powder A after sterilizing, add distilled water reflux, extract, containing 20-50% ethanol 3 times, return with the ethanol of 3 times amount every time Stream extracts 0.5 hour, filters united extraction liquid, and reclaims ethanol, is concentrated into relative density 1.05-1.15, adds 75% ethanol In right amount, making medicinal liquid alcohol content promote 0.5 times, limit edged is sufficiently stirred for, and stands 12-24h, filters, and reclaims ethanol to without alcohol taste, Clear paste, then add DDW to containing crude drug 0.5-1g/ml, medicinal liquid adds percentage by weight 1-3% activated carbon, after heated and boiled, Cooling, stand at low temperature 6-12h after filtration, obtain water-soluble medicine soup, filter off medicinal residues and obtain fried medicinal liquid.
4) the chopping medical material of step (1) is squeezed into juice, and mixes to obtain raw pharmacy liquid, life pharmacy liquid is heated to 60～65 DEG C, And it is cooled to 5 DEG C rapidly after keeping this temperature 30-60min.
5) the raw pharmacy liquid of aforementioned for step (3) gained fried medicinal liquid and step (4) gained is mixed, be filtered to remove medicine further Slag, slow evaporation concentrates becomes thickness ointment, obtains described Chinese medicine composition.
The preparation method of the Chinese medicine composition of aforementioned therapies chronic gastritis, it is characterised in that: be previously mentioned clean, refer to Repeatedly wash with distilled water；After aforementioned fried medicinal liquid and raw pharmacy liquid are mixed by described step (5), then carry out multiple times of filtration with fully Ground removes medicinal residues, then is evaporated concentrating, and is properly added adjuvant in evaporating concentration process, at residual moisture at 3%-4% Between time, carry out the preparation of tablet by the mode of mechanical presses, under extraordinary air flow communication, carry out humidity strip be dried, Being dried 3-5 days at 15-25 DEG C, sampling 0.5-1.5% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
Embodiment 2
A kind of Chinese medicine composition treating chronic gastritis, it is characterised in that: described Chinese medicine composition is each by following weight parts proportioning Component forms: Rhizoma Corydalis 12 parts, Fructus Amomi 9 parts, Herba Pogostemonis 10 parts, Fructus Crataegi 16 parts, Endothelium Corneum Gigeriae Galli 10 parts, 15 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 10 parts, Piper longum 6 parts, Fructus Evodiae 9 parts, Semen Alpiniae Katsumadai 8 parts, Cortex Magnoliae Officinalis 9 parts, Radix Codonopsis 6 parts, Concha Arcae 8 parts, sea Piao sheath 12 Part, Rhizoma Coptidis 14 parts, Semen Raphani 16 parts, the Radix Astragali 11 parts, honey Flos Inulae 18 parts, Radix Notoginseng 10 parts, Flos Cucurbitae 15 parts, mattress Old 15 parts, 14 parts of good rattan, Herba Taraxaci 15 parts, Herba Hedyotidis Diffusae 16 parts, Semen Cassiae 12 parts, grass Herba Dendrobii 12 parts, Semen Coicis Core 18 parts, wild Radix paulowniae 12 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 15 parts of Pericarpium Citri Reticulatae Viride, 12 parts of Semen Persicae.
Protect the preparation method of a kind of Chinese medicine composition treating chronic gastritis, choose the Chinese drug-treated group of foregoing weight Compound raw material, and follow the steps below and be prepared from:
1) processing of medical material step: calcine: the uncovered calcine of Concha Arcae heatproof container, shreds standby；Processed with vinegar: take and totally dry Rhizoma Corydalis, according to stir-baking with vinegar fried dry, smashs to pieces standby；Salt system: take the Fructus Amomi totally dried, adds saline and mixes thoroughly, the most vexed, treats saline After being sucked, putting in parch container, heat with slow fire, fried dry, taking-up is dried in the air cool, smashs to pieces standby；Parch: Semen Raphani, Rhizoma Cyperi, Sea Piao sheath, Semen Coicis clean rear parch, chopping；Yellow wine system:: take Fructus Piperis Longi clean dry, every 50 grams add 500 milliliters of yellow wine Middle immersion 7 days, removes nature and dries, chopping；Chopping: by Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae Flower, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae, remove residual Root and impurity, pick clean impurity, the destemming leaf that takes, sieve dedusting bits, clean chopping；Processed with honey: the Radix Astragali, Fructus Evodiae, Cortex Magnoliae Officinalis, Radix Codonopsis.
2) calcine of step (1), processed with vinegar, salt system, parch, yellow wine system, the medical material co-grinding of processed with honey gained are crossed 160 Mesh sieve, mixes by weight, obtains former powder A, and stirs with ultra violet lamp sterilization or use co-60 radiation sterilizing 30-60min, co-60 radiation sterilizing dose 1-3Kgy.
3) by the former powder A after sterilizing, add distilled water reflux, extract, containing 30-60% ethanol 4 times, return with the ethanol of 4 times amount every time Stream extracts 0.5-1.5 hour, filters united extraction liquid, and reclaims ethanol, is concentrated into relative density 1.15-1.25, adds 75% Appropriate amount of ethanol, makes medicinal liquid alcohol content promote 0.5-1 times, and limit edged is sufficiently stirred for, and stands 12-24h, filters, and reclaims ethanol extremely Taste without alcohol, obtains clear paste, then adds DDW to containing crude drug 1-1.5g/ml, and medicinal liquid adds percentage by weight 1-3% activated carbon, heating After boiling, cooling, stand at low temperature 6-12h after filtration, obtain water-soluble medicine soup, filter off medicinal residues and obtain fried medicinal liquid.
4) the chopping medical material of step (1) is squeezed into juice, and mixes to obtain raw pharmacy liquid, life pharmacy liquid is heated to 65～70 DEG C, And it is cooled to 5 DEG C rapidly after keeping this temperature 30-60min.
5) the raw pharmacy liquid of aforementioned for step (3) gained fried medicinal liquid and step (4) gained is mixed, be filtered to remove medicine further Slag, slow evaporation concentrates becomes thickness ointment, obtains described Chinese medicine composition.
The preparation method of the Chinese medicine composition of aforementioned therapies chronic gastritis, it is characterised in that: be previously mentioned clean, refer to Repeatedly wash with distilled water；After aforementioned fried medicinal liquid and raw pharmacy liquid are mixed by described step (5), then carry out multiple times of filtration with fully Ground removes medicinal residues, then is evaporated concentrating, and is properly added adjuvant in evaporating concentration process, at residual moisture at 4%-5% Between time, carry out the preparation of tablet by the mode of mechanical presses, under extraordinary air flow communication, carry out humidity strip be dried, Being dried 4-6 days at 15-25 DEG C, sampling 0.5-1.5% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
Embodiment 3
A kind of Chinese medicine composition treating chronic gastritis, it is characterised in that: described Chinese medicine composition is each by following weight parts proportioning Component forms: Rhizoma Corydalis 12 parts, Fructus Amomi 9 parts, Herba Pogostemonis 12 parts, Fructus Crataegi 18 parts, Endothelium Corneum Gigeriae Galli 10 parts, 15 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 10 parts, Piper longum 6 parts, Fructus Evodiae 9 parts, Semen Alpiniae Katsumadai 9 parts, Cortex Magnoliae Officinalis 9 parts, Radix Codonopsis 6 parts, Concha Arcae 8 parts, sea Piao sheath 12 Part, Rhizoma Coptidis 15 parts, Semen Raphani 18 parts, the Radix Astragali 12 parts, honey Flos Inulae 18 parts, Radix Notoginseng 12 parts, Flos Cucurbitae 18 parts, mattress Old 18 parts, 15 parts of good rattan, Herba Taraxaci 18 parts, Herba Hedyotidis Diffusae 18 parts, Semen Cassiae 12 parts, grass Herba Dendrobii 12 parts, Semen Coicis Core 18 parts, wild Radix paulowniae 12 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 15 parts of Pericarpium Citri Reticulatae Viride, 12 parts of Semen Persicae.
Protect the preparation method of a kind of Chinese medicine composition treating chronic gastritis, choose the Chinese drug-treated group of foregoing weight Compound raw material, and follow the steps below and be prepared from:
1) processing of medical material step: calcine: the uncovered calcine of Concha Arcae heatproof container, shreds standby；Processed with vinegar: take and totally dry Rhizoma Corydalis, according to stir-baking with vinegar fried dry, smashs to pieces standby；Salt system: take the Fructus Amomi totally dried, adds saline and mixes thoroughly, the most vexed, treats saline After being sucked, putting in parch container, heat with slow fire, fried dry, taking-up is dried in the air cool, smashs to pieces standby；Parch: Semen Raphani, Rhizoma Cyperi, Sea Piao sheath, Semen Coicis clean rear parch, chopping；Yellow wine system:: take Fructus Piperis Longi clean dry, every 50 grams add 400 milliliters of yellow wine Middle immersion 7 days, removes nature and dries, chopping；Chopping: by Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae Flower, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae, remove residual Root and impurity, pick clean impurity, the destemming leaf that takes, sieve dedusting bits, clean chopping；Processed with honey: the Radix Astragali, Fructus Evodiae, Cortex Magnoliae Officinalis, Radix Codonopsis.
2) calcine of step (1), processed with vinegar, salt system, parch, yellow wine system, the medical material co-grinding of processed with honey gained are crossed 200 Mesh sieve, mixes by weight, obtains former powder A, and stirs with ultra violet lamp sterilization or use co-60 radiation sterilizing 30-60min, co-60 radiation sterilizing dose 1-3Kgy.
3) by the former powder A after sterilizing, add distilled water reflux, extract, containing 40-70% ethanol 5 times, return with the ethanol of 5 times amount every time Stream extracts 0.5-1.5 hour, filters united extraction liquid, and reclaims ethanol, is concentrated into relative density 1.25-1.45, adds 75% Appropriate amount of ethanol, makes medicinal liquid alcohol content promote 0.5-1 times, and limit edged is sufficiently stirred for, and stands 12-24h, filters, and reclaims ethanol extremely Taste without alcohol, obtains clear paste, then adds DDW to containing crude drug 1.5-2g/ml, and medicinal liquid adds percentage by weight 1-3% activated carbon, heating After boiling, cooling, stand at low temperature 6-12h after filtration, obtain water-soluble medicine soup, filter off medicinal residues and obtain fried medicinal liquid.
4) the chopping medical material of step (1) is squeezed into juice, and mixes to obtain raw pharmacy liquid, life pharmacy liquid is heated to 70～75 DEG C, And it is cooled to 5 DEG C rapidly after keeping this temperature 30-60min.
5) the raw pharmacy liquid of aforementioned for step (3) gained fried medicinal liquid and step (4) gained is mixed, be filtered to remove medicine further Slag, slow evaporation concentrates becomes thickness ointment, obtains described Chinese medicine composition.
The preparation method of the Chinese medicine composition of aforementioned therapies chronic gastritis, it is characterised in that: be previously mentioned clean, refer to Repeatedly wash with distilled water；After aforementioned fried medicinal liquid and raw pharmacy liquid are mixed by described step (5), then carry out multiple times of filtration with fully Ground removes medicinal residues, then is evaporated concentrating, and is properly added adjuvant in evaporating concentration process, at residual moisture at 5%-6% Between time, carry out the preparation of tablet by the mode of mechanical presses, under extraordinary air flow communication, carry out humidity strip be dried, Being dried 5-7 days at 15-25 DEG C, sampling 0.5-1.5% determines tablet whether sufficiently dry, obtains the Chinese medicine composition tablet made.
The above, the only detailed description of the invention of the present invention, but protection scope of the present invention is not limited thereto, any without Cross change or replacement that creative work is expected, all should contain within protection scope of the present invention.Therefore, the protection of the present invention Scope should be as the criterion with the protection domain that claims are limited.

Claims (6)

1. the Chinese medicine composition treating chronic gastritis, it is characterised in that: described Chinese medicine composition is by each group of following weight parts proportioning It is grouped into:
Rhizoma Corydalis 6-12 part, Fructus Amomi 6-12 part, Herba Pogostemonis 6-15 part, Fructus Crataegi 9-18 part, Endothelium Corneum Gigeriae Galli 6-18 part, Rhizoma Zingiberis Recens 10-20 part, Rhizoma Cyperi 5-15 part, Piper longum 3-9 part, Fructus Evodiae 3-9 part, Semen Alpiniae Katsumadai 3-9 part, Cortex Magnoliae Officinalis 3-9 part, Radix Codonopsis 2-6 part, Concha Arcae 2-8 part, sea Piao sheath 3-12 part, Rhizoma Coptidis 3-15 part, Semen Raphani 9-18 part, Radix Astragali 6-12 part, honey Flos Inulae 9-18 part, three Seven 3-12 parts, Flos Cucurbitae 6-18 part, Herba Artemisiae Scopariae 6-18 part, good rattan 3-15 part, Herba Taraxaci 3-18 part, Herba Hedyotidis Diffusae 3-18 Part, Semen Cassiae 3-12 part, grass Herba Dendrobii 3-12 part, Semen Coicis 6-18 part, wild Radix paulowniae 3-12 part, Radix Et Caulis Acanthopanacis Senticosi 6-18 part, green grass or young crops Skin 5-15 part, Semen Persicae 3-12 part.
A kind of Chinese medicine composition treating chronic gastritis the most according to claim 1, it is characterised in that: described Chinese medicine composition by Each component composition of following weight parts proportioning:
Rhizoma Corydalis 9-12 part, Fructus Amomi 6-9 part, Herba Pogostemonis 6-12 part, Fructus Crataegi 12-18 part, Endothelium Corneum Gigeriae Galli 6-10 part, Rhizoma Zingiberis Recens 10-15 part, Rhizoma Cyperi 5-10 part, Piper longum 3-6 part, Fructus Evodiae 6-9 part, Semen Alpiniae Katsumadai 5-9 part, Cortex Magnoliae Officinalis 6-9 part, Radix Codonopsis 4-6 part, Concha Arcae 5-8 part, sea Piao sheath 6-12 part, Rhizoma Coptidis 9-15 part, Semen Raphani 12-18 part, Radix Astragali 9-12 part, honey Flos Inulae 12-18 part, Radix Notoginseng 6-12 part, Flos Cucurbitae 9-18 part, Herba Artemisiae Scopariae 12-18 part, good rattan 9-15 part, Herba Taraxaci 9-18 part, Herba Hedyotidis Diffusae 9-18 Part, Semen Cassiae 9-12 part, grass Herba Dendrobii 6-12 part, Semen Coicis 12-18 part, wild Radix paulowniae 6-12 part, Radix Et Caulis Acanthopanacis Senticosi 9-18 part, green grass or young crops Skin 9-15 part, Semen Persicae 8-12 part.
A kind of Chinese medicine composition treating chronic gastritis the most according to claim 2, it is characterised in that: described Chinese medicine composition by Each component composition of following weight parts proportioning:
Rhizoma Corydalis 10 parts, Fructus Amomi 6 parts, Herba Pogostemonis 8 parts, Fructus Crataegi 14 parts, Endothelium Corneum Gigeriae Galli 7 parts, 12 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 6 parts, Bi Pull out 4 parts, Fructus Evodiae 8 parts, Semen Alpiniae Katsumadai 6 parts, Cortex Magnoliae Officinalis 6 parts, Radix Codonopsis 4 parts, Concha Arcae 6 parts, sea 8 parts of Piao sheath, Rhizoma Coptidis 9 parts, Semen Raphani 12 parts, the Radix Astragali 9 parts, honey Flos Inulae 12 parts, Radix Notoginseng 8 parts, Flos Cucurbitae 9 parts, Herba Artemisiae Scopariae 12 parts, good rattan 10 parts, Herba Taraxaci 10 parts, Herba Hedyotidis Diffusae 10 parts, Semen Cassiae 9 parts, grass Herba Dendrobii 6 parts, Semen Coicis 12 parts, wild Radix paulowniae 6 Part, Radix Et Caulis Acanthopanacis Senticosi 10 parts, 10 parts of Pericarpium Citri Reticulatae Viride, 10 parts of Semen Persicae.
A kind of Chinese medicine composition treating chronic gastritis the most according to claim 2, it is characterised in that: described Chinese medicine composition by Each component composition of following weight parts proportioning:
Rhizoma Corydalis 12 parts, Fructus Amomi 9 parts, Herba Pogostemonis 10 parts, Fructus Crataegi 16 parts, Endothelium Corneum Gigeriae Galli 10 parts, 15 parts of Rhizoma Zingiberis Recens, Rhizoma Cyperi 10 parts, Piper longum 6 parts, Fructus Evodiae 9 parts, Semen Alpiniae Katsumadai 8 parts, Cortex Magnoliae Officinalis 9 parts, Radix Codonopsis 6 parts, Concha Arcae 8 parts, 12 parts of the Piao sheath in sea, Huang Even 14 parts, Semen Raphani 16 parts, the Radix Astragali 11 parts, honey Flos Inulae 18 parts, Radix Notoginseng 10 parts, Flos Cucurbitae 15 parts, Herba Artemisiae Scopariae 15 parts, 14 parts of good rattan, Herba Taraxaci 15 parts, Herba Hedyotidis Diffusae 16 parts, Semen Cassiae 12 parts, grass Herba Dendrobii 12 parts, Semen Coicis 18 parts, Wild Radix paulowniae 12 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, 15 parts of Pericarpium Citri Reticulatae Viride, 12 parts of Semen Persicae.
5. the preparation method of the Chinese medicine composition treating chronic gastritis, it is characterised in that choose such as the weight of claim 1 or 2 The traditional Chinese medicine composite of part proportioning, and follow the steps below and be prepared from:
1) processing of medical material step:
Calcine: the uncovered calcine of Concha Arcae heatproof container, pulverizes standby；
Processed with vinegar: take the Rhizoma Corydalis totally dried, according to stir-baking with vinegar fried dry, smashs to pieces standby；
Salt system: take the Fructus Amomi totally dried, adds saline and mixes thoroughly, the most vexed, after saline is sucked, puts in parch container, adds with slow fire Heat, fried dry, taking-up is dried in the air cool, is smashed to pieces standby；
Parch: Semen Raphani, Rhizoma Cyperi, sea Piao sheath, Semen Coicis clean rear parch, pulverize；
Yellow wine system:: taking Fructus Piperis Longi and clean and dry, every 50 grams add in 400 milliliters of yellow wine and soak 7, remove nature and dry, pulverize； Chopping: by Herba Pogostemonis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Rhizoma Zingiberis Recens, Rhizoma Coptidis, honey Flos Inulae, Radix Notoginseng, Flos Cucurbitae, Herba Artemisiae Scopariae, good rattan, Pu Herba Taraxaci, Herba Hedyotidis Diffusae, Semen Cassiae, grass Herba Dendrobii, wild Radix paulowniae, remove undesirable root and impurity, picks clean impurity, the destemming leaf that takes, sieve Dedusting is considered to be worth doing. clean chopping；
Processed with honey: the Radix Astragali, Fructus Evodiae, Cortex Magnoliae Officinalis, Radix Codonopsis；
2) calcine of step (1), processed with vinegar, salt system, parch, yellow wine system, the medical material co-grinding of processed with honey gained are crossed 120-200 Mesh sieve, mixes by weight, obtains former powder A, and stirs with ultra violet lamp sterilization or use co-60 radiation sterilizing 30-60min, co-60 radiation sterilizing dose 1-3Kgy；
3) by the former powder A after sterilizing, distilled water reflux, extract, containing 20-70% ethanol is added 3-5 time, every time with the ethanol of 3-5 times amount Reflux, extract, 0.5-1.5 hour, filters united extraction liquid, and reclaims ethanol, be concentrated into relative density 1.05-1.45, adds 75% appropriate amount of ethanol, makes medicinal liquid alcohol content promote 0.5-1 times, and limit edged is sufficiently stirred for, and stands 12-24h, filters, and reclaims second Alcohol to without alcohol taste, obtains clear paste, then adds DDW extremely containing crude drug 0.5-2g/ml, and medicinal liquid adds percentage by weight 1-3% activated carbon, After heated and boiled, cooling, stand at low temperature 6-12h after filtration, obtain water-soluble medicine soup, filter off medicinal residues and obtain fried medicinal liquid；
4) the chopping medical material of step (1) is squeezed into juice, and mix to obtain raw pharmacy liquid, life pharmacy liquid is heated to 60～75 DEG C, and 5 DEG C it are cooled to rapidly after keeping this temperature 30-60min；
5) the raw pharmacy liquid of aforementioned for step (3) gained fried medicinal liquid and step (4) gained is mixed, is filtered to remove medicinal residues further, Slow evaporation concentrates becomes thickness ointment, obtains described Chinese medicine composition.
6. the preparation method of the Chinese medicine composition of a treatment chronic gastritis as claimed in claim 5, it is characterised in that:
Claim 5 is mentioned clean, refer to washes repeatedly with distilled water；Described step (5) by aforementioned fried medicinal liquid and After raw pharmacy liquid mixing, then carry out multiple times of filtration to remove medicinal residues fully, then be evaporated concentrating, and in evaporation and concentration mistake Journey is properly added adjuvant, when residual moisture is between 3%-6%, carries out the preparation of tablet by the mode of mechanical presses, non- Carrying out humidity strip under the best air flow communication to be dried, be dried 3-7 days at 15-25 DEG C, sampling 0.5-1.5% determines that tablet is No sufficiently dry, obtains the Chinese medicine composition tablet made.
CN201610285778.0A 2016-05-03 2016-05-03 Traditional Chinese medicine composition for treating chronic gastritis and preparation method thereof Pending CN105797119A (en)

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Application publication date: 20160727