CN105521182A - Preparation for treating pancreatic cancer and preparation method of preparation - Google Patents

Preparation for treating pancreatic cancer and preparation method of preparation Download PDF

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CN105521182A
CN105521182A CN201610058015.2A CN201610058015A CN105521182A CN 105521182 A CN105521182 A CN 105521182A CN 201610058015 A CN201610058015 A CN 201610058015A CN 105521182 A CN105521182 A CN 105521182A
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herba
preparation
kunth
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不公告发明人
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K35/586—Turtles; Tortoises, e.g. terrapins
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a preparation for treating pancreatic cancer. The preparation is prepared from the following main medicinal materials in parts by weight: 4-8 parts of herb of greater celandine, 7-13 parts of fleshfingered citron flowers, 5-10 parts of herb of jamaica falsevalerian, 6-12 parts of seeds of Indian trumetflower, 3-7 parts of (prepared) carapax trionycis, 5-9 parts of cortex albiziae, 4-7 parts of dwarf elm fruits, 8-12 parts of the seeds of cowherb, 9-13 parts of Giant St. John's wort, 6-11 parts of trogopterus dung, 8-13 parts of Chinese granesbill, 5-12 parts of root of Chinese eriosema, 7-12 parts of tuber of Amorphophallus virosus N.E.Browu, 6-13 parts of herb of smallflower beggarticks, and 4-9 parts of leaf of paniculate microcosm. The preparation has the efficacies of clearing away heat and toxic materials, soothing the liver and regulating the circulation of qi, promoting blood circulation to remove blood stasis, eliminating pathogen and strengthening vital qi, as well as warming channel and expelling cold, and can reduce the mass within a short time, effectively control the cancer cell metastasis and proliferation, and enhance the body immunity while treating and resisting cancer, and the pain of the patients is alleviated.

Description

A kind of preparation and preparation method curing cancer of pancreas
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and the preparation method of curing cancer of pancreas.
Background technology
Cancer of pancreas is common pancreas tumor, is that a kind of grade malignancy is very high, the malignant tumor of digestive tract that Diagnosis and Treat is all very difficult, and about 90% for originating from the duct adenocarcinoma of glandular tube epithelium, and its M & M obviously rises in recent years.5 years survival rate <1%, it is one of the poorest malignant tumor of prognosis, the early stage diagnosis rate of cancer of pancreas is not high, operative mortality is higher, and cure rate is very low, primary disease sickness rate male is higher than women, and the ratio of men and women is 1.5-2:1, male patient is common far beyond premenopausal women, and sickness rate and the male of postmenopausal women are similar.40-70 year is common, and male is more than women.Sickness rate has and increases trend in recent years.Spinal column is close at the rear that pancreas is positioned at epigastrium stomach, and Diseases In Pancreatic Head is held by duodenal segment, and carcinoma accounts for 2/3 more than herein, and 90% is duct cell carcinoma.The cause of disease is still not fully aware of, its occur with smoking, drink, higher fatty acid relevant with high protein diet, excessive coffee for drinking, environmental pollution and inherited genetic factors.
The common Clinical symptoms of cancer of pancreas loses weight, suffers from abdominal pain and jaundice.Losing weight is a kind of nonspecific symptom, normally gradual, namely starts to occur before the confirmation cancer of pancreas several months.The patient of 65%-80% has stomachache, often even more serious night.Horizontal position and seat can make pain increase the weight of.Jaundice is the 3rd modal symptom, and many patients occur more late.Jaundice normally Progressive symmetric erythrokeratodermia increases the weight of, but also has in natural fluctuation state.Jaundice often with the annoying pruritus of upper arm, shank and abdominal part, increases the weight of at night especially.The non-specific S&S of cancer of pancreas comprises anorexia, ascending cholangitis, and the change of bowl evacuation habit (constipation, diarrhoea, malabsorption, flatulence, or intestinal tympanites).Can be there is melancholia, doubt disease and hysteria in middle age, be commonly considered as being caused by cancer of pancreas.
At present, also have a lot for Pancreas cancer patients radiation period drug administration, publication number CN104707110A(application number 201510165074.5) patent document discloses a kind of Chinese medicine preparation for cancer of pancreas and preparation method, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Bupleuri (processed with vinegar) 13-17 part, Radix Curcumae 13-17 part, vinegar Rhizoma Corydalis 16-20 part, Lignum Dalbergiae Odoriferae 4-8 part, Lignum Aquilariae Resinatum 1-5 part, Radix Notoginseng 8-12 part, Rhizoma Polygoni Cuspidati 16-20 part, Fructus Setariae Germinatus (parched) 13-17 part, Fructus Hordei Germinatus (parched) 13-17 part, Fructus Crataegi (parched) 13-17 part, Massa Medicata Fermentata preparata 13-17 part, Fructus Akebiae 16-20 part, Rhizoma Menispermi 7-11 part, Radix Glehniae 18-22 part, Rhizoma Atractylodis Macrocephalae (parched) 22-26 part, Poria 13-17 part, Radix Pseudostellariae 10-14 part, Semen Coicis 28-32 part, Herba Hedyotidis Diffusae 18-22 part, Herba Lobeliae Chinensis 18-22 part, Herba Solani Lyrati 10-14 part, Radix Paeoniae Alba 13-17 part, Radix Glycyrrhizae Preparata 4-8 part.Publication number CN1036110911A (application number 201310669009.7) patent document discloses a kind of preparation for the treatment of cancer of pancreas, the crude drug of its Chinese medicine is made up of the component of following weight parts proportioning: Semen Ziziphi Spinosae 240-270 part, Radix Astragali 100-115 part, Radix Codonopsis 100-115 part, Rhizoma Atractylodis Macrocephalae 65-80 part, Semen Coicis core 100-115 part, Herba Hedyotidis Diffusae 100-115 part, Poria 75-85 part, Fructus Akebiae 75-85 part, Herba Scutellariae Barbatae 95-110 part, Herba Salviae Chinensis 75-85 part, Radix Polygalae 60-75 part, Radix Glycyrrhizae 20-25 part, Radix Bupleuri 120-145 part, Rhizoma Cyperi 40-55 part, Radix Curcumae 40-55 part, Fructus Citri Sarcodactylis 45-60 part, Herba Lobeliae Chinensis 70-85 part, Rhizoma Corydalis 45-60 part, Rhizoma Chuanxiong 25-30 part, Pericarpium Citri Reticulatae 14-19 part, Rhizoma Pinelliae 100-115 part, Cortex Magnoliae Officinalis 8-13 part, Flos Calystegiae sepii 60-75 part, Radix Paeoniae Alba 28-35 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 65-80 part.Patent document discloses of publication number CN104958594A (application number 201510382756.1) a kind ofly treats Chinese medicine of stagnation of QI-blood type cancer of pancreas and preparation method thereof, and its raw medicinal material comprises: Bambusa pervariabilis Meclure., Rhizoma Arundinis Donacis, Cortex Holarrhenae Antidysentericae, Herba lygodii, Herba Bulbophylli inconspicui, Scytosiphon lomentarius (Lyngh.)J. Ag., Mirabilitum, Cortex Cudraniae tricuspidatae, Herba erysimi cheiranthoidis, Radix Celastri Angulati, Radix Cinnamomi Camphorae, Fructus Vaccinii Bracteati, Herba Pentanematis Indici, Bulbophyllum cylinolraceun Linoll., Herba pronephrii triphylli, lobus cardiacus Folium seu radix sidae mysorensis and Herba Coreopsis tinctoria.
The treatment of current cancer of pancreas does not also have a kind of comprehensive therapeutic plan efficiently can applied completely, and still based on surgical operation therapy, radiotherapy, chemotherapy are auxiliary.But because of the early diagnosis difficulty of cancer of pancreas, Resection Rate is low, prognosis mala, and survival rates is also low; Chemicotherapy effectively can kill cancerous cell, but also can kill and wound normal cell simultaneously, makes the immunity degradation of patient, occurs more complication, bring very big damage to patient body.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of preparation of curing cancer of pancreas, there is the effect of heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian, lump can be reduced in a short time, effective control cancer cell metastasis diffusion, for cancer anticancer while enhancing human body immunity power, alleviate patient suffering.Another object is just to provide the preparation method of above-mentioned preparation.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Cure a preparation for cancer of pancreas, take off the primary raw material stating weight proportion and be prepared from: Herba Chelidonii 4-8 part; Flos Citri Sarcodactylis 7-13 part; Herba Stachytarphetae Jamaicensis 5-10 part; Semen Oroxyli 6-12 part; (processing) Carapax Trionycis 3-7 part; Cortex Albiziae 5-9 part; Fructus seu semen ulmi pumilae 4-7 part; Semen Vaccariae 8-12 part; Herba Hyperici 9-13 part; Oletum Trogopterori 6-11 part; Geranium strictipes R. Kunth 8-13 part; Radix eriosematis chinensis 5-12 part; Rhizoma Amorphophalli virosi 7-12 part; Herba bidentis parviflorae 6-13 part; Folium Microcoris paniculatae 4-9 part.
Cure a preparation for cancer of pancreas, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Herba Chelidonii 5-7 part; Flos Citri Sarcodactylis 9-11 part; Herba Stachytarphetae Jamaicensis 7-9 part; Semen Oroxyli 8-10 part; (processing) Carapax Trionycis 4-6 part; Cortex Albiziae 6-8 part; Fructus seu semen ulmi pumilae 5-6 part; Semen Vaccariae 9-11 part; Herba Hyperici 10-12 part; Oletum Trogopterori 8-10 part; Geranium strictipes R. Kunth 10-12 part; Radix eriosematis chinensis 8-10 part; Rhizoma Amorphophalli virosi 9-11 part; Herba bidentis parviflorae 9-11 part; Folium Microcoris paniculatae 6-8 part.
Cure a preparation for cancer of pancreas, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Herba Chelidonii 6 parts; Flos Citri Sarcodactylis 10 parts; Herba Stachytarphetae Jamaicensis 8 parts; Semen Oroxyli 9 parts; (processing) Carapax Trionycis 5 parts; Cortex Albiziae 7 parts; Fructus seu semen ulmi pumilae 5.5 parts; Semen Vaccariae 10 parts; Herba Hyperici 11 parts; Oletum Trogopterori 9 parts; Geranium strictipes R. Kunth 11 parts; Radix eriosematis chinensis 9 parts; Rhizoma Amorphophalli virosi 10 parts; Herba bidentis parviflorae 10 parts; Folium Microcoris paniculatae 7 parts.
Present invention also offers the preparation method above-mentioned a kind of preparation of curing cancer of pancreas being made pharmaceutically acceptable oral liquid, granule, capsule, pill and tablet.
Described a kind of preparation method curing the preparation oral liquid of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method 15-20 minute, dry, be placed in pulverizer and pulverize, excessively 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
According to preparation method recited above, step (1) preferably microwave combustion method frequency is 1800-2000MHz, and being more preferably microwave combustion method frequency is 1900MHz.
Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.
Described a kind of preparation method curing the preparation granules agent of cancer of pancreas, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water, soak 3-5 hour, squeezing extracting juice, adds step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, make uniform fine particle, encapsulate with the specification of every parcel 6g.
According to preparation method recited above, the consumption of step (3) preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 15 days courses for the treatment of.
Described a kind of preparation method curing the preparation capsule of cancer of pancreas, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, dry, pulverize, cross 180-220 mesh sieve (preferred cross 190-210 mesh sieve, be more preferably 200 mesh sieves);
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.45-0.55g/ grain, being more preferably the specification by 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
Instructions of taking: each 2, every day 3 times, 15 days courses for the treatment of.
Described a kind of preparation method curing the preparation pill of cancer of pancreas, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, dry, pulverize, cross 120-140 mesh sieve;
(6) by Mel, (consumption of preferred Mel is the 10%-20% of medicated powder quality, the consumption being more preferably Mel is 15% of medicated powder quality) be placed in pot, temper with slow fire, endure to thick Deng Mel, mix step (5) gained medicated powder again, fully mix into ointment thoroughly, (preferred diameter is 3-5mm to make pill, being more preferably diameter is 4mm), obtain pill.
Instructions of taking: each 6-10 ball, every day 3 times, 15 days courses for the treatment of.
Described a kind of preparation method curing the formulation tablet of cancer of pancreas, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.10-1.20(30 DEG C) thick paste, make uniform granule, tabletting, sugar coating, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.
The pharmacological effect of each crude drug is respectively:
Herba Chelidonii: bitter in the mouth, cool in nature.Return lung, the heart, kidney channel.For the herb of bloodroot Herba Chelidonii.There is town disease, cough-relieving, diuresis, effect of removing toxic substances.For stomachache, stomachache, enteritis, dysentery, chronic bronchitis, pertussis, cough, jaundice, edema, ascites, scabies skin ulcer swells, snake bite and insect sting.
Flos Citri Sarcodactylis: mildly bitter flavor, slightly warm in nature.Return liver, stomach warp.For flower and the alabastrum of rutaceae Fructus Citri Sarcodactylis.There is depressed liver-energy dispersing and QI regulating, stomach function regulating soon every effect.For stomachache due to hyperactive liver-QI attacking the stomach, inappetence.
Herba Stachytarphetae Jamaicensis: sweet in the mouth, micro-hardship, cold in nature.GUIXIN, liver, kidney channel.For herb and the root of the false horsewhip of Verbenaceae.There is clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling.For pyretic stranguria, stranguria caused by urinary stone, nebulousurine, leucorrhea, rheumatic ostalgia, acute conjunctivitis, pharyngolaryngitis, gingivitis, cholecystitis, carbuncle furuncle, hemorrhoid, treating swelling and pain by traumatic injury.
Semen Oroxyli: bitter in the mouth, sweet, cool in nature.Return lung, liver, stomach warp.For the dry mature seed of Bignoniaceae plant oroxylum indicum.There is removing heat from the lung and relieving sorethroat, effect of dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
(processing) Carapax Trionycis: salty in the mouth, cold nature.Return liver, kidney channel.For the carapace of Trionychidae animal Trionyx sinensis (Wiegmann) and Trionyxs teindachneri Siebenrock．.There is nourishing YIN and clearing away heat, suppressing hyper-yang to eliminate wind, effect of hard masses softening and resolving.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, consumption of YIN caused by febrile disease, stirring-up of pathogenic wind in the interior resulting from deficiency, littlely makes infantile convulsion, chronic malaria, malaria with splenomegaly, lump in the abdomen, amenorrhea.Carapax Trionycis (processed): get sand and put in pot, after making popular with high heat, adds clean Carapax Trionycis, constantly stirs, scald to surface faint yellow, takes out, and sieve removes sand, quench in vinegar, and dry, the used time smashs to pieces.Every Carapax Trionycis 100kg, uses vinegar 20kg.
Cortex Albiziae: sweet in the mouth, property is put down.GUIXIN, liver, lung meridian.For the dry bark of leguminous plant Herba Albiziae.There is resolving stagnation for tranquilization, effect of promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.
Fructus seu semen ulmi pumilae: bitter in the mouth, micro-pungent, property is put down.For the fruits and seeds of Ulmaceae elm.There is spleen-benefiting mind-tranquilizing, clearing away heat and promoting diuresis, effect of detumescence parasite killing.For women leucorrhea, children's's infantile malnutrition with fever weakness and emaciation, insomnia, inappetence, leukorrhagia, dysuria, edema, children's's infantile malnutrition with fever is won thin, burn and scald, skin ulcer tinea.
Semen Vaccariae: bitter in the mouth, property is put down.Return liver, stomach warp.For the dry mature seed of pinkwort Vaccaria segetalis.There is promoting blood circulation to restore menstrual flow, effect of stimulating milk secretion detumescence.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
Herba Hyperici: bitter in the mouth, cold in nature.Return Liver Channel.For the herb of Garcinia maingayii hypericum ascyron.There is cooling blood for hemostasis, promoting blood flow to regulate menstruation, effect of heat-clearing and toxic substances removing.Spit blood caused by heat in blood, spitting of blood, hematuria, has blood in stool, metrorrhagia, traumatic injury, traumatic hemorrhage, menoxenia, dysmenorrhea, agalactia, anemopyretic cold, malaria, hepatitis, dysentery, diarrhoea, and venom is scalded, eczema, impetigo.
Oletum Trogopterori: bitter in the mouth, sweet, warm in nature.Return liver, spleen channel.For the dry feces of flying squirrel section animal trogopterus xanthipes Milne-Edwards.There is promoting blood circulation and stopping pain, removing stasis to stop bleeding, effect of removing food stagnancy removing toxic substances.For all pains of trusted subordinate's vim and vigour, women's amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, metrostaxis, infantile malnutrition, snakes and scorpions centipete bite.
Geranium strictipes R. Kunth: bitter in the mouth, puckery, cold nature.Return liver, spleen, stomach, urinary bladder channel.For the root of MangNiu Er Seedling section plant Radix Geranii Strictipedis and five jiaos of leaf Herba Erodiis.There is clearing away heat-damp and promoting diuresis, effect of cooling blood for hemostasis.For having loose bowels, dysentery, dyspepsia, gastral cavity abdomen, epistaxis, has blood in stool, and has through too much, and postpartum hemorrhage is more than, traumatic injury.
Radix eriosematis chinensis: sweet in the mouth, property is put down.Return lung, large intestine, Liver Channel.For the tuber of leguminous plant Radix eriosematis chinensis.There is removing heat from the lung and dissipating phlegm, promoting the production of body fluid to quench thirst, effect of detumescence.For cough due to lung-heat, lung abscess, heating excessive thirst, dysentery, hydrocele of testis, food stagnation does not disappear, treating swelling and pain by traumatic injury.
Rhizoma Amorphophalli virosi: acrid in the mouth, sweet, slightly warm in nature.For the tuber of aroid wart handle mill taro.There is soothing liver and strengthening spleen, effect of detoxicating and resolving stagnation of pathogens.For chronic persistent hepatitis.
Herba bidentis parviflorae: mildly bitter flavor, micro-pungent, cool in nature.For the herb of feverfew Herba bidentis parviflorae.There is clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, effect of promoting blood circulation and hemostasis.For dysentery, edema of having loose bowels, cough, asthma, tonsillitis, hemoptysis, hematuria, carbuncle furuncle and phyma poison, herpes zoster, treating swelling and pain by traumatic injury, traumatic hemorrhage.
Folium Microcoris paniculatae: sour in the mouth, light, property is put down.Return spleen channel.For the leaf of Tiliaceae plant Folium Microcoris paniculatae.Have clearing away heat-damp and promoting diuresis, stomach invigorating disappears stagnant effect.For cold, fever, jaundice, inappetence, dyspepsia, abdominal distention, has loose bowels, skin infection, centipete bite.
Beneficial effect of the present invention is mainly reflected in:
1, invention formulation has the effect of heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian, can reduce lump in a short time, effectively controls cancer cell metastasis diffusion, has wide market application foreground.
2, invention formulation formula is reasonable, and remarkable through this medicine therapeutic effect of clinical verification, treatment cycle is short, cheap, has no adverse reaction and any toxic and side effects, for cancer anticancer while enhancing human body immunity power, alleviate patient suffering.
3, invention formulation employing Common Chinese Herbs is refining forms, and cost is low, rapid-action, good effect, taking convenience.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds cures the preparation of cancer of pancreas, takes off to state primary raw material and be prepared from (getting 70g for every part): Herba Chelidonii 4 parts; Flos Citri Sarcodactylis 7 parts; Herba Stachytarphetae Jamaicensis 5 parts; Semen Oroxyli 6 parts; (processing) Carapax Trionycis 3 parts; Cortex Albiziae 5 parts; Fructus seu semen ulmi pumilae 4 parts; Semen Vaccariae 8 parts; Herba Hyperici 9 parts; Oletum Trogopterori 6 parts; Geranium strictipes R. Kunth 8 parts; Radix eriosematis chinensis 5 parts; Rhizoma Amorphophalli virosi 7 parts; Herba bidentis parviflorae 6 parts; Folium Microcoris paniculatae 4 parts.
Above-mentioned a kind of preparation method curing the preparation oral liquid of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (baking temperature is 65 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), and soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.
Embodiment 2 one kinds cures the preparation of cancer of pancreas, takes off to state primary raw material and be prepared from (getting 30g for every part): Herba Chelidonii 8 parts; Flos Citri Sarcodactylis 13 parts; Herba Stachytarphetae Jamaicensis 10 parts; Semen Oroxyli 12 parts; (processing) Carapax Trionycis 7 parts; Cortex Albiziae 9 parts; Fructus seu semen ulmi pumilae 7 parts; Semen Vaccariae 12 parts; Herba Hyperici 13 parts; Oletum Trogopterori 11 parts; Geranium strictipes R. Kunth 13 parts; Radix eriosematis chinensis 12 parts; Rhizoma Amorphophalli virosi 12 parts; Herba bidentis parviflorae 13 parts; Folium Microcoris paniculatae 9 parts.
Above-mentioned a kind of preparation method curing the preparation granules agent of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 50 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), and soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, make uniform fine particle, encapsulate with the specification of every parcel 6g.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 15 days courses for the treatment of.
Model case one: road XX, female, 56 years old, people from Accessories during Binzhou, Shandong Province.Mrs Lu is a secondary school teachers, and retirement, just more than 2 years, is about to the life after enjoying retirement, but feels lower abdomen rest pain, with the disease such as vomiting with acid regurgitation, inappetence.So remove examination in hospital, be diagnosed as pancreatitis, infusion treatment is after one week, and symptom is alleviated to some extent.But occur the diseases such as abdominal discomfort again after about 2 months, be diagnosed as cancer of pancreas on inspection, ocal resection, operation is relatively smooth, but testedly when postoperative half a year checks find cancer return.
After taking the present invention a kind of 2 courses for the treatment of of preparation (embodiment 2) of curing cancer of pancreas, the disease such as abdominal pain, inappetence obviously alleviates, and nausea and vomiting phenomenon disappears, and the mental status is also obviously improved.After continuing to take 2 courses for the treatment of, check CT shows that pancreatic mass disappears, and health greatly takes a turn for the better.Follow up a case by regular visits to 1 year, do not occur other malaise symptoms, recover good.
Embodiment 3 one kinds cures the preparation of cancer of pancreas, takes off to state primary raw material and be prepared from (getting 60g for every part): Herba Chelidonii 5 parts; Flos Citri Sarcodactylis 9 parts; Herba Stachytarphetae Jamaicensis 7 parts; Semen Oroxyli 8 parts; (processing) Carapax Trionycis 4 parts; Cortex Albiziae 6 parts; Fructus seu semen ulmi pumilae 5 parts; Semen Vaccariae 9 parts; Herba Hyperici 10 parts; Oletum Trogopterori 8 parts; Geranium strictipes R. Kunth 10 parts; Radix eriosematis chinensis 8 parts; Rhizoma Amorphophalli virosi 9 parts; Herba bidentis parviflorae 9 parts; Folium Microcoris paniculatae 6 parts.
Above-mentioned a kind of preparation method curing the preparation capsule of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2 times), and soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 45 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, dry, pulverize, cross 200 mesh sieves;
(6) step (5) gained medicated powder is made capsule by the specification of 0.5g/ grain.
Using method: each 2, every day 3 times, 15 days courses for the treatment of.
Embodiment 4 one kinds cures the preparation of cancer of pancreas, takes off to state primary raw material and be prepared from (getting 20g for every part): Herba Chelidonii 7 parts; Flos Citri Sarcodactylis 11 parts; Herba Stachytarphetae Jamaicensis 9 parts; Semen Oroxyli 10 parts; (processing) Carapax Trionycis 6 parts; Cortex Albiziae 8 parts; Fructus seu semen ulmi pumilae 6 parts; Semen Vaccariae 11 parts; Herba Hyperici 12 parts; Oletum Trogopterori 10 parts; Geranium strictipes R. Kunth 12 parts; Radix eriosematis chinensis 10 parts; Rhizoma Amorphophalli virosi 11 parts; Herba bidentis parviflorae 11 parts; Folium Microcoris paniculatae 8 parts.
Above-mentioned a kind of preparation method curing the preparation pill of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 200 mesh sieves;
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), and soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, dry, pulverize, cross 130 mesh sieves;
(6) Mel (consumption is 15% of medicated powder quality) is placed in pot, tempers with slow fire, wait Mel to endure to thick, then mix step (5) gained medicated powder, fully mix into ointment thoroughly, make the pill that diameter is 4mm, obtain pill.
Instructions of taking: each 6-10 ball, every day 3 times, 15 days courses for the treatment of.
Model case two: poplar XX, man, 51 years old, people from Tai'an, Shandong Province.Mr. Yang is the employee of certain enterprise, occurs discontinuity upper abdominal pain, abdominal distention before 2 years, and with nausea and vomiting, after carrying out anti-inflammatory treatment, symptom is without alleviation, and the sign increased the weight of gradually, and vomiting obviously.Remove examination in hospital, result is diagnosed as cancer of pancreas, and after being treated surgically, the state of an illness is temporarily controlled, but just occurs cancer return less than year, health skeletonize.
After taking the present invention a kind of 2 courses for the treatment of of preparation (embodiment 4) of curing cancer of pancreas, the mental status takes a turn for the better, and chest dull pain disappears, and nausea and vomiting pain all alleviates.After continuing to take 2 courses for the treatment of, CT checks: pancreas normal in size has no occupy-place sexually transmitted disease (STD).Immune indexes platelet, leukocyte are also normal.Visit health so far always fine, without relapse and metastasis.
Embodiment 5 one kinds cures the preparation of cancer of pancreas, takes off to state primary raw material and be prepared from (getting 40g for every part): Herba Chelidonii 6 parts; Flos Citri Sarcodactylis 10 parts; Herba Stachytarphetae Jamaicensis 8 parts; Semen Oroxyli 9 parts; (processing) Carapax Trionycis 5 parts; Cortex Albiziae 7 parts; Fructus seu semen ulmi pumilae 5.5 parts; Semen Vaccariae 10 parts; Herba Hyperici 11 parts; Oletum Trogopterori 9 parts; Geranium strictipes R. Kunth 11 parts; Radix eriosematis chinensis 9 parts; Rhizoma Amorphophalli virosi 10 parts; Herba bidentis parviflorae 10 parts; Folium Microcoris paniculatae 7 parts.
Above-mentioned a kind of preparation method curing the formulation tablet of cancer of pancreas, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method (microwave combustion method frequency is 1900MHz) 18 minutes, dry, be placed in pulverizer and pulverize, cross 220 mesh sieves;
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (baking temperature is 70 DEG C), burn into ashes completely, add water boil 55 minutes, leave standstill 25 minutes, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), and soak 4 hours, squeezing extracting juice, adds step (1) gained medicated powder, moistening 50 minutes, filters, obtains medicinal liquid;
(4) be placed in marmite by Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae, add step (2) gained supernatant, soak 35 minutes, decoct with water twice, each decoction 35 minutes, filters, and merges, obtains filtrate;
(5) by step (3) gained medicinal liquid and step (4) gained filtrate mixing, be concentrated into relative density 1.15(30 DEG C) thick paste, make uniform granule, tabletting, sugar coating, make tablet.
Instructions of taking: each 2, every day 3 times, 15 days courses for the treatment of.
Test example: in order to verify a kind of curative effect curing the preparation (embodiment 5) of cancer of pancreas of the present invention, We conducted contrast test.Experiment sieving Pancreas cancer patients 240 people, wherein male 129 example, women 111 example, during patient assessment, minimal ages is 32 years old, max age 75 years old.Be divided into matched group and experimental group randomly, wherein experimental group has 160 people, and matched group has 80 people.
Experimental group: take a kind of preparation of curing cancer of pancreas of the present invention, each 2, every day 3 times, 15 days courses for the treatment of; Matched group: take other drug (as Tegafur-uracil mixt. sheet, Kang Lixin capsule etc.), wherein, Tegafur-uracil mixt. sheet: oral, 3 times on the one, each 2-4 sheet or follow the doctor's advice.Kang Lixin capsule: oral, a 2-3 grain, 3 times on the one; Or follow the doctor's advice.
Criterion of therapeutical effect: cure: tumor disappearance, without other transfer signs, the mental status takes a turn for the better, and check indices is normal, follows up a case by regular visits to 3 years without recurrence sign; Effective: tumor obviously reduces, the mental status is obviously improved, and check indices obviously improves; Invalid: symptom is without obvious alleviation, and check indices is not improved.Wherein effectively comprise cure and effective.
Every day same equal time, medication under square one, and observe simultaneously, record the health often organizing patient.Take the matched group of other drug and take a kind of Comparison of therapeutic curing the experimental group of the preparation of cancer of pancreas of the present invention, result is as shown in table 1:
Table 1
Efficacy analysis: as can be seen from Table 1, take a kind of cure rate of curing the preparation of cancer of pancreas of the present invention up to 68.13%, effective percentage is 95%, and the cure rate taking other drug only reaches 41.25%, and effective percentage is also only 73.75%.So a kind of preparation of curing cancer of pancreas of the present invention is compared with the medicine of other treatment cancer of pancreas, its curative effect increases substantially, and cure rate is high, and inefficiency is low, evident in efficacy, greatly improves and stabilizes therapeutic effect.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. cure a preparation for cancer of pancreas, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Herba Chelidonii 4-8 part; Flos Citri Sarcodactylis 7-13 part; Herba Stachytarphetae Jamaicensis 5-10 part; Semen Oroxyli 6-12 part; (processing) Carapax Trionycis 3-7 part; Cortex Albiziae 5-9 part; Fructus seu semen ulmi pumilae 4-7 part; Semen Vaccariae 8-12 part; Herba Hyperici 9-13 part; Oletum Trogopterori 6-11 part; Geranium strictipes R. Kunth 8-13 part; Radix eriosematis chinensis 5-12 part; Rhizoma Amorphophalli virosi 7-12 part; Herba bidentis parviflorae 6-13 part; Folium Microcoris paniculatae 4-9 part.
2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Herba Chelidonii 5-7 part; Flos Citri Sarcodactylis 9-11 part; Herba Stachytarphetae Jamaicensis 7-9 part; Semen Oroxyli 8-10 part; (processing) Carapax Trionycis 4-6 part; Cortex Albiziae 6-8 part; Fructus seu semen ulmi pumilae 5-6 part; Semen Vaccariae 9-11 part; Herba Hyperici 10-12 part; Oletum Trogopterori 8-10 part; Geranium strictipes R. Kunth 10-12 part; Radix eriosematis chinensis 8-10 part; Rhizoma Amorphophalli virosi 9-11 part; Herba bidentis parviflorae 9-11 part; Folium Microcoris paniculatae 6-8 part.
3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Herba Chelidonii 6 parts; Flos Citri Sarcodactylis 10 parts; Herba Stachytarphetae Jamaicensis 8 parts; Semen Oroxyli 9 parts; (processing) Carapax Trionycis 5 parts; Cortex Albiziae 7 parts; Fructus seu semen ulmi pumilae 5.5 parts; Semen Vaccariae 10 parts; Herba Hyperici 11 parts; Oletum Trogopterori 9 parts; Geranium strictipes R. Kunth 11 parts; Radix eriosematis chinensis 9 parts; Rhizoma Amorphophalli virosi 10 parts; Herba bidentis parviflorae 10 parts; Folium Microcoris paniculatae 7 parts.
4., according to the preparation method of the arbitrary described preparation oral liquid of claim 1-3, it is characterized in that, step is as follows:
(1) Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae are carried out microwave combustion method 15-20 minute, dry, be placed in pulverizer and pulverize, excessively 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, filter, sterile packaged.
5. preparation method according to claim 4, is characterized in that: step (1) preferably microwave combustion method frequency is 1800-2000MHz, and being more preferably microwave combustion method frequency is 1900MHz.
6., according to the preparation method of the arbitrary described preparation granules agent of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water, soak 3-5 hour, squeezing extracting juice, adds step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, make uniform fine particle, encapsulate with the specification of every parcel 6g.
7. preparation method according to claim 6, is characterized in that: the consumption of step (3) preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times.
8., according to the preparation method of the arbitrary described preparation capsule of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, dry, pulverize, cross 180-220 mesh sieve;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.45-0.55g/ grain, being more preferably the specification by 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
9., according to the preparation method of the arbitrary described preparation pill of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, dry, pulverize, cross 120-140 mesh sieve;
(6) by Mel, (consumption of preferred Mel is the 10%-20% of medicated powder quality, the consumption being more preferably Mel is 15% of medicated powder quality) be placed in pot, temper with slow fire, endure to thick Deng Mel, mix step (5) gained medicated powder again, fully mix into ointment thoroughly, (preferred diameter is 3-5mm to make pill, being more preferably diameter is 4mm), obtain pill.
10., according to the preparation method of the arbitrary described formulation tablet of claim 1-3, it is characterized in that, step is as follows:
(1) (preferred microwave combustion method frequency is 1800-2000MHz Semen Oroxyli, Fructus seu semen ulmi pumilae and Semen Vaccariae to be carried out microwave combustion method, being more preferably microwave combustion method frequency is 1900MHz) 15-20 minute, dry, be placed in pulverizer to pulverize, cross 180-220 mesh sieve (preferred 190-210 mesh sieve excessively, was more preferably 220 mesh sieves);
(2) Herba Stachytarphetae Jamaicensis, Herba Hyperici and Herba bidentis parviflorae are placed in drying machine dry (preferred baking temperature is 65-75 DEG C, and being more preferably baking temperature is 70 DEG C), burn into ashes completely, add water boil 50-60 minute, leave standstill 20-30 minute, remove the impurity on surface, get supernatant, for subsequent use;
(3) Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi are smashed, be placed in container, add water (consumption of preferred water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 2-4 doubly, the consumption being more preferably water be Geranium strictipes R. Kunth, Radix eriosematis chinensis and Rhizoma Amorphophalli virosi quality 3 times), soak 3-5 hour, squeezing extracting juice, add step (1) gained medicated powder, moistening 40-60 minute, filters, obtains medicinal liquid;
(4) Herba Chelidonii, Flos Citri Sarcodactylis, (processing) Carapax Trionycis, Cortex Albiziae, Oletum Trogopterori and Folium Microcoris paniculatae are placed in marmite, add step (2) gained supernatant, soak 30-40 minute, decoct with water twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, is more preferably each decoction 35 minutes), filters, merge, obtain filtrate;
(5) by step (3) gained medicinal liquid and the mixing of step (4) gained filtrate, be concentrated into the thick paste of relative density 1.10-1.20, make uniform granule, tabletting, sugar coating, make tablet.
CN201610058015.2A 2016-01-28 2016-01-28 Preparation for treating pancreatic cancer and preparation method of preparation Withdrawn CN105521182A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1772255A (en) * 2005-09-27 2006-05-17 韩云超 Chinese medicine for treating liver cancer and carcinoma of pancreas
CN101209263A (en) * 2006-12-26 2008-07-02 朴贞子 Medicine for treating tumor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1772255A (en) * 2005-09-27 2006-05-17 韩云超 Chinese medicine for treating liver cancer and carcinoma of pancreas
CN101209263A (en) * 2006-12-26 2008-07-02 朴贞子 Medicine for treating tumor

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