CN103432341B - Chinese herbal medicine oral liquid for treating chronic paratyphoid fever of piglets - Google Patents
Chinese herbal medicine oral liquid for treating chronic paratyphoid fever of piglets Download PDFInfo
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- CN103432341B CN103432341B CN201310419635.0A CN201310419635A CN103432341B CN 103432341 B CN103432341 B CN 103432341B CN 201310419635 A CN201310419635 A CN 201310419635A CN 103432341 B CN103432341 B CN 103432341B
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Abstract
The invention discloses a Chinese herbal medicine oral liquid for treating chronic paratyphoid fever of piglets. The Chinese herbal medicine oral liquid is prepared from the following material medicines in parts by weight: 5-6 parts of purslane, 5-6 parts of plantain herbs, 4-5 parts of schisandra chinensis, 4-5 parts of gallnuts, 3-4 parts of aleppo galls, 2-3 parts of Chinese yams, 2-3 parts of rhizoma atractylodis, 2-3 parts of alums, 2-3 parts of dried alums and 1-2 parts of liquorices. The Chinese herbal medicine oral liquid disclosed by the invention is used for treating chronic paratyphoid fever of piglets, and has the characteristics of low cost, high cure rate, good effect, no toxic and side effect and the like, and is safe and convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicament oral liquid for the treatment of the chronic paratyphoid fever of piglet.
Background technology
The chronic paratyphoid fever of piglet is developed or be at the beginning chronic process by acute paratyphoid fever.Principal character symptom is dysentery, and feces is atherosclerotic or water sample, is greyish white, yellowish, yellowish green, grayish green or dirty black, and stench, is often mixed with mucus, even mucosa or blood.When serious,, all can there is dysentery in anal incontinence in the time eating food, couch or stand up and walk, and feces is naturally dirty, and afterbody and whole rear quarters are stain, and when some coughs, is spray discharge loose stool water.The chronic paratyphoid fever of piglet often betide 6 the monthly age following piglet, particularly 2～4 the monthly age piglet common.The medicine of the chronic paratyphoid fever for the treatment of piglet is much Antibiotics Western medicine, although have certain therapeutic effect, shortcoming is that Drug resistance is more serious.That Chinese herbal medicine has is natural, have no side effect, residual without chemicals, the feature such as be difficult for developing immunity to drugs.The Chinese medicine preparation that is used for the treatment of at present the chronic paratyphoid fever of piglet is less, and weak effect, and cure rate is low, and the course for the treatment of is long, and cost is high.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicament oral liquid that can effectively treat the chronic paratyphoid fever of piglet is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicament oral liquid for the treatment of the chronic paratyphoid fever of piglet, it is made up of the crude drug of following weight parts: Herba Portulacae 5-6, Herba Plantaginis 5-6 part, Fructus Schisandrae Chinensis 4-5 part, Galla Chinensis 4-5 part, Galla Turcica (Galla Helepensis) 3-4 part, Rhizoma Dioscoreae 2-3 part, Rhizoma Atractylodis 2-3 part, Alumen 2-3 part, dried Alumen 2-3 part, Radix Glycyrrhizae 1-2 part.
The preferred feedstock medicine weight portion of making the Chinese herbal medicament oral liquid that the present invention treats the chronic paratyphoid fever of piglet is: Herba Portulacae 6,6 parts of Herba Plantaginiss, 5 parts of Fructus Schisandrae Chinensis, 4 parts of Galla Chinensiss, 3 parts of Galla Turcica (Galla Helepensis)s, 3 parts of Rhizoma Dioscoreaes, 2 parts of Rhizoma Atractylodis, 2 parts of Alumens, 2 parts of dried Alumens, 1 part, Radix Glycyrrhizae.
In prescription of the present invention, each component pharmacological effect is:
Herba Portulacae effect: Herba Portulacae another name long life dish, five elements' oxalic acid taste dish, longevity greens/mustard green etc., cold in nature, sour in the mouth.Return large intestine, liver, spleen channel.Herb is containing a large amount of noradrenalins and volume potassium salt potassium nitrate, potassium chloride, potassium sulfate etc.In addition, still containing dihydroxy benzenes ethamine, dihydroxyphenylalanine, malic acid, citric acid, glutamic acid etc.Herba Portulacae has effect of heat-clearing and toxic substances removing.Be used for bacillary dysentery etc.
Herba Plantaginis effect: Herba Plantaginis has another name called wheel dish, Gaster Sus domestica dish, ash pan grass etc., property is sweet, light, be slightly cold, and returns lung, liver, kidney, urinary bladder channel.Herba Plantaginis seed is containing a month aucubin, Herba Plantaginis mucopolysaccharide, racemization-plantagoside, all square rafter glycoside acid etc., and effect of tool eliminating dampness by diuresis antidiarrheal, for edema distension, heat-damp in summer dysentery etc.
Fructus Schisandrae Chinensis effect: Fructus Schisandrae Chinensis another name Fructus Zanthoxyli Plansipini, sliding weight of steelyard etc., sour in the mouth, warm in nature.Return, the heart, kidney channel.Bearberry Extract is astringent or styptic treatment for spontaneous sweating, effect of supplementing QI for promoting the production of body fluid, kidney calming., lose heart deficient pulse etc. thirsty for incessant chronic diarrhea, Tianjin wound.
Galla Chinensis effect: Galla Chinensis another name Fructus rhois chinensis, Galla Chinensis tree etc., sour in the mouth, puckery, cold in nature.Return lung, large intestine, kidney channel.Astringe the lung effect of hidroschesis, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, hemostasis removing toxic substances of tool.For spontaneous sweating, chronic dysentery chronic diarrhea, proctoptosis etc.
Galla Turcica (Galla Helepensis) effect: Galla Turcica (Galla Helepensis) calls black stone, without infanticide, do not have stone etc.Bitter in the mouth, warm in nature.Return lung, spleen, kidney channel.Containing gallotannin, gallic acid etc.Tool solid and gas arresting seminal emission, the hemostasia effect of astringing the lung.Sliding for asthenia of the large intestine, dysentery more than, have blood in stool etc.
Rhizoma Dioscoreae effect: Rhizoma Dioscoreae another name Rhizomadioscoreae, Rhizoma dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, profit cool in nature, sweet in the mouth, return lung, spleen, kidney channel.Rhizoma Dioscoreae is containing ruscogenin, polyphenol oxidase, again containing glycoprotein, polysaccharide, cholesterol, various trace elements etc.Effect of tool spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, for insufficiency of the spleen lack of appetite, have loose bowels loose stool, incessant chronic diarrhea etc.
Rhizoma Atractylodis effect: Rhizoma Atractylodis are called red art, blue or green art, magic arts, the pungent temperature of property, bitter in the mouth.Return spleen, stomach, Liver Channel.Rhizome is containing volatile oil, left-handed α Bisabolol terpene alcohol etc.Contain again atractylin alcohol, acetyl group atractylin alcohol etc.There is effect drying damp and strengthening spleen, wind-damp dispelling.For inappetence, the spleen and stomach being stranded by dampness, vomiting unhappiness, abdominal distention is had loose bowels etc.
Alumen effect: another name Alumen, Gypsum Fibrosum, raw vitriol etc., sour-puckery flavor, cold.Return lung, spleen, liver, large intestine, urinary bladder channel.Effect of tool expectorant dampness, antidiarrheal hemostasis, removing toxic substances parasite killing.For jaundice, gastroduodenal ulcer, dysentery, epistaxis etc.
Dried Alumen effect: have another name called calcined Alumen, nature and flavor are sour and astringent, cold.Return lung, spleen, stomach, large intestine channel.Effect of tool expectorant dampness, antidiarrheal hemostasis, removing toxic substances parasite killing.For gastroduodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis etc.
Radix Glycyrrhizae effect: Radix Glycyrrhizae another name Glycyrrhizae, close sweet, close grass, state are old, Herba Hedyotis cantonensis, leather and fur.Property is put down, sweet in the mouth.Return 12 warps.Radix Glycyrrhizae is mainly containing compositions such as glycyrrhizic acids, glycyrrhizin Angelica Polysaccharide, has antiulcer, promotes pancreatic secretion, protects the liver, the effect such as the phagocytic function of blood fat reducing, adjusting macrophage.Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, maintains water-electrolyte metabolism balance etc.Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, cushion toxicity, strong.
Prescription foundation of the present invention: the chronic paratyphoid fever of piglet is to infect Salmonella before and after weaned piglet, and endotoxic effect makes piglet long-term diarrhea, severe patient death.Therefore in treatment, should be taking anti-inflammation, spleen invigorating dysentery relieving, enhancing immunity as the rule for the treatment of.Herba Portulacae, Herba Plantaginis heat-clearing and toxic substances removing, anti-inflammation in side, Fructus Schisandrae Chinensis, Galla Chinensis, Galla Turcica (Galla Helepensis) is drying damp and strengthening spleen, anti-inflammation, Alumen, dried Alumen, Rhizoma Dioscoreae, Rhizoma Atractylodis spleen invigorating dysentery relieving, improves body's immunity, the sweet temperature QI invigorating of Radix Glycyrrhizae and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription.In side all medicine phases and, the effect of playing altogether heat-clearing and toxic substances removing, anti-inflammation, spleen invigorating dysentery relieving, enhancing immunity, is applicable to the chronic paratyphoid fever of piglet.For strengthening prevention effect, make oral liquid.
The present invention treats the Chinese herbal medicament oral liquid of the chronic paratyphoid fever of piglet, to carry out on the basis of a large amount of practical applications, according to traditional medicine ancient prescription, form in conjunction with sick of modern popular, the theoretical screening of nosetiology, the chronic paratyphoid fever of piglet is had to good therapeutic effect.
Detailed description of the invention
The invention will be further described in conjunction with the embodiments.
Embodiment:
1, difference weighting raw materials (decoction pieces): Herba Portulacae 180 g, Herba Plantaginis 180 g, Fructus Schisandrae Chinensis 150 g, Galla Chinensis 120 g, Galla Turcica (Galla Helepensis) 90 g, Rhizoma Dioscoreae 90 g, Rhizoma Atractylodis 60 g, Alumen 60 g, dried Alumen 40 g, Radix Glycyrrhizae 30g;
2, above-mentioned raw materials medicine is ground into respectively to coarse powder;
3, get above-mentioned ten taste Chinese herbal medicine coarse powder, after 8000 mL that add water soak 1h, decoct, water is opened rear slow fire boiling 30min; Filter to obtain first-time filtrate, medicinal residues 6000 mL that at every turn add water again decoct secondaries, and each 20min filters respectively to obtain secondary and three filtrates; Merge three times filtrate, be concentrated into approximately 900 mL;
4, by concentrated solution obtained above, add 0.05% sodium benzoate as antiseptic, add water to 1000mL, stir evenly, filter, fill, sterilizing, obtains Chinese herbal medicament oral liquid of the present invention.
Some test situation of utilizing herbal prescription of the present invention to carry out are as follows:
1, Chinese herbal medicament oral liquid of the present invention is to the drug sensitive test of swine enteritis Salmonella
Choose the chronic paratyphoid fever case of clinical trouble piglet, through separating, identifying pathogen as swine enteritis Salmonella.Get a certain amount of Chinese herbal medicament oral liquid of the present invention, every mL contains crude drug 1g, sterilizing, and subpackage, 4 DEG C save backup.The swine enteritis Salmonella of clinical separation is first inoculated in to flat board, cultivates after 18 h in 37 DEG C, select colonies typical and be inoculated in 5 mL meat soups, cultivate after 18 h in 37 DEG C, 0.5 Maxwell unit's standard opacity tube is than turbid, bacterium liquid is diluted to 10 with meat soup
5cFU/mL, for subsequent use.
Medicament sensitivity test: adopt plate punch method, add 1g/mL Chinese herbal medicament oral liquid of the present invention in hole, overfolw hole is not advisable outward to fill it up with.Choose and generally acknowledged the good three kinds of antibiotic of swine enteritis Salmonella effect are compared as the drug sensitive test of ofloxacin (1 μ g/mL), amikacin (1 μ g/mL), ceftiofur sodium (1 μ g/mL), be placed in 37 DEG C of constant incubators and cultivate 24 h, measure antibacterial circle diameter, the drug sensitive test of every kind of medicine in triplicate.Criterion: the standard according to " pharmacology of Chinese materia medica " with " Standardization Institute of clinical laboratory of U.S. version in 2005 is about drug sensitive test standardization ", be that bacteriostatic diameter >=20 mm is for extremely quick, 20 mm> bacteriostatic diameter >=15 mm are Gao Min, 15 mm> bacteriostatic diameter >=10 mm are quick in being, 10 mm are hypoallergenic below.
Chinese herbal medicament oral liquid medicament sensitivity test of the present invention the results are shown in Table 1.
The drug sensitive test result mm of table 1 Chinese herbal medicament oral liquid of the present invention
| Medicine | Swine enteritis Salmonella |
| Ofloxacin | 18.0±0.4 |
| Amikacin | 19.5±0.1 |
| Ceftiofur sodium | 20.5±0.3 |
| Chinese herbal medicament oral liquid of the present invention | 21.8±0.5 |
Table 1 shows, to swine enteritis Salmonella, Chinese herbal medicament oral liquid of the present invention is for extremely quick, and bacteriostatic diameter reaches 21.8 mm, and ofloxacin, amikacin, ceftiofur sodium are Gao Min.Drug sensitivity test shows, the inhibitory action of Chinese herbal medicament oral liquid swine enteritis Salmonella of the present invention is the most responsive, and ceftiofur sodium takes second place, and amikacin, ofloxacin are slightly time.Result shows, Chinese herbal medicament oral liquid of the present invention should be served as first-selection in the chronic paratyphoid fever practice for the treatment of piglet.
2, the clinical trial of the chronic paratyphoid fever of natural infection piglet:
Be " DLY " tri-crossbreeding on pig farm, Funing County, Hebei province for examination pig, select 40 age in days 20-25 ages in days and suffer from Hakuri pig, be divided at random 4 groups, 10 every group.Experimental period 7d.Sick pig, by recommended dose administration, is calculated cure rate, respectively organizes the cure rate of piglet in table 2.
The cure rate (head, %) of the each group of table 2 piglet
| Group | Dosage | Sample size | Diarrhoea number | Cure rate | Death toll | Mortality rate |
| I group | Not medication group | 10 | 8 | 0 | 1 | 10 |
| II group | Amikacin 10mg/kg, injection, day 2 times | 10 | 2 | 80 | 0 | 0 |
| III group | Ceftiofur sodium 2.0mg/ kg, injection, day 2 times | 10 | 2 | 80 | 0 | 0 |
| IV group | Oral liquid group 10mL/ head of the present invention, oral, day 2 times | 10 | 1 | 90 | 0 | ? |
As shown in Table 2, the 5d of test, dead 1 of I group, all the other each group at duration of test all without dead, after off-test, II group, III group and IV group cure rate respectively 80%, 80% and 90%; Oral liquid of the present invention can improve the cure rate of the chronic paratyphoid fever of piglet, and is slightly better than commercially available antibiotic as amikacin, ceftiofur sodium.
Claims (2)
1. treat the Chinese herbal medicament oral liquid of the chronic paratyphoid fever of piglet for one kind, it is characterized in that it is to be made up of the crude drug of following weight parts: Herba Portulacae 5-6, Herba Plantaginis 5-6 part, Fructus Schisandrae Chinensis 4-5 part, Galla Chinensis 4-5 part, Galla Turcica (Galla Helepensis) 3-4 part, Rhizoma Dioscoreae 2-3 part, Rhizoma Atractylodis 2-3 part, Alumen 2-3 part, dried Alumen 2-3 part, Radix Glycyrrhizae 1-2 part.
2. the Chinese herbal medicament oral liquid of the chronic paratyphoid fever for the treatment of piglet according to claim 1, it is characterized in that it is to be made up of the crude drug of following weight parts: Herba Portulacae 6,6 parts of Herba Plantaginiss, 5 parts of Fructus Schisandrae Chinensis, 4 parts of Galla Chinensiss, 3 parts of Galla Turcica (Galla Helepensis)s, 3 parts of Rhizoma Dioscoreaes, 2 parts of Rhizoma Atractylodis, 2 parts of Alumens, 2 parts of dried Alumens, 1 part, Radix Glycyrrhizae.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222378A (en) * | 1998-01-06 | 1999-07-14 | 莫育运 | Chinese medicine for acute and chronic diarrhea, dysentery with purulent and bloody stools, as well as acute and chronic colitis |
| CN1548135A (en) * | 2003-05-18 | 2004-11-24 | 张喜臣 | Chinese medicine for treating animal's dysenteric diarrhoea and its prepn process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102512651B (en) * | 2012-01-06 | 2014-05-28 | 张树森 | Traditional Chinese medicament for treating yellow-white dysentery of baby pigs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222378A (en) * | 1998-01-06 | 1999-07-14 | 莫育运 | Chinese medicine for acute and chronic diarrhea, dysentery with purulent and bloody stools, as well as acute and chronic colitis |
| CN1548135A (en) * | 2003-05-18 | 2004-11-24 | 张喜臣 | Chinese medicine for treating animal's dysenteric diarrhoea and its prepn process |
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Granted publication date: 20141210 Termination date: 20180916 |