CN103432245B - Chinese herbal medicine oral liquid for treating piglet white diarrhea - Google Patents
Chinese herbal medicine oral liquid for treating piglet white diarrhea Download PDFInfo
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- CN103432245B CN103432245B CN201310419634.6A CN201310419634A CN103432245B CN 103432245 B CN103432245 B CN 103432245B CN 201310419634 A CN201310419634 A CN 201310419634A CN 103432245 B CN103432245 B CN 103432245B
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Abstract
The invention relates to a Chinese herbal medicine oral liquid for treating piglet white diarrhea. The Chinese herbal medicine oral liquid is characterized by being prepared from the following material medicines in parts by weight: 8-10 parts of common andrographis herbs, 6-8 parts of humifuse euphorbia herbs, 3-4 parts of plantain herbs, 3-4 parts of gentian, 2-4 parts of spreading hedyotis herbs, 2-3 parts of Echinacea, 2-3 parts of astragalus membranaceus, 1-2 parts of rhizoma cimicifugae and 1-2 parts of liquorices. The Chinese herbal medicine oral liquid disclosed by the invention is used for treating the piglet white diarrhea, has the characteristics of low cost, high cure rate, good effect, no toxic and side effect and the like, and is safe and convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicament oral liquid for the treatment of piglet pujos blancos.
Background technology
Piglet pujos blancos is the diarrhoeal diseases common within age of sucking of piglet.Be characterized as disease piglet milk ejection white or canescence is smelt as of rotten fish loose stool, piglet growth speed obviously slowed down, causes heavy losses to raiser.The medicine for the treatment of piglet pujos blancos is much Antibiotics Western medicine, although have certain therapeutic effect, shortcoming is that Drug resistance is more serious.Chinese herbal medicine have natural, have no side effect, residual without chemicals, not easily the feature such as to develop immunity to drugs.Be used for the treatment of piglet pujos blancos Chinese medicine preparation at present less, and weak effect, cure rate is low, and the course for the treatment of is long, and cost is high.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicament oral liquid effectively can treating piglet pujos blancos is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicament oral liquid for the treatment of piglet pujos blancos, it is made up of the crude drug of following weight parts: Herba Andrographis 8-10 part, Herba Euphorbiae Humifusae 6-8 part, Herba Plantaginis 3-4 part, Radix Gentianae 3-4 part, Herba Hedyotidis Diffusae 2-4 part, Echinacea 2-3 part, Radix Astragali 2-3 part, Rhizoma Cimicifugae 1-2 part, Radix Glycyrrhizae 1-2 part.
Making the preferred feedstock medicine weight portion that the present invention treats the Chinese herbal medicament oral liquid of piglet pujos blancos is: Herba Andrographis 8 parts, Herba Euphorbiae Humifusae 6 parts, Herba Plantaginis 4 parts, Radix Gentianae 4 parts, Herba Hedyotidis Diffusae 3 parts, Echinacea 3 parts, the Radix Astragali 2 parts, Rhizoma Cimicifugae 1 part, 1 part, Radix Glycyrrhizae.
In prescription of the present invention, each component pharmacological effect is:
Herba Andrographis effect: Herba Andrographis has another name called Chun Lianqiuliu, Herba Andrographitis, Radix Gentianae etc., bitter in the mouth is cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Folium Andrographis contains Diterpenes if andrographolide, flavonoid, Polyphenols are as caffeic acid, chlorogenic acid and two caffeoyl silicon thujic acid mixture; Root is containing flavonoid as andrographin etc., and aerial parts contains Diterpenes as andrographolide etc.Andrographolide has the effect suppressing and delay Diplococcus pneumoniae and the rising of the body temperature caused by hemolytic group B streptococcus.Water decoction can improve the ability that peripheral blood leucocyte engulfs staphylococcus aureus in vitro, effect of tool heat-clearing and toxic substances removing, removing heat from blood detumescence, for multi-infection disease, comprises trauma infection contamination, acute bacillary dysentery, acute gastroenteritis etc.
Herba Euphorbiae Humifusae effect: Herba Euphorbiae Humifusae another name Rhizoma Polygoni Paleachi, Herba Chenopodii Hybridi grass, Herba Chenopodii Hybridi etc., the flat acrid in the mouth of property, returns lung, liver, stomach, large intestine, urinary bladder channel.Herba Euphorbiae Humifusae is containing three kinds of flavonoid glycoside, and wherein the glycoside unit of two glycosides is nimbecetin, and the glycoside unit of another glycoside is Quercetin, also contains gallate-based methyl ester and meso inositol, effect of tool heat-clearing and toxic substances removing, dampness removing jaundice eliminating, for dysentery, have loose bowels, jaundice etc.
Herba Plantaginis effect: Herba Plantaginis has another name called wheel dish, grass, Herba Potentillae Chinensis etc. are filled with in Gaster Sus domestica dish, ash pan grass, field, property is sweet, light, be slightly cold, and returns lung, liver, kidney, urinary bladder channel.Herba Plantaginis seed is containing moon aucubin, and Herba Plantaginis mucopolysaccharide, choline and fatty oil, cupreol etc., effect of tool eliminating dampness by diuresis antidiarrheal, for edema distension, heat-damp in summer dysentery etc.
Radix Gentianae effect: the mound trip of Radix Gentianae another name, careless Radix Gentianae, Radix Gentianae, bitter Radix Gentianae etc., bitter in the mouth cold in nature, returns liver, gallbladder meridian.Radix Gentianae is containing gentiopicrin, swertiamarin, sweroside, trilobatin, amarogentin, gentiopicroside tetraacetate etc., and effect of tool heat clearing and damp drying, eliminating pathogen in the liver arresting convulsion, for jaundice due to damp-heat etc.
Herba Hedyotidis Diffusae effect: Herba Hedyotidis Diffusae another name Herba Hedyotidis Diffusae, Chinese Lobelia, short foot spend in vain Chinese Lobelia, etc., Herba Hedyotidis Diffusae containing rubichloric acid., rubichloric acid. acid, go the acid of acetate rubichloric acid., all square rafter glycoside acid etc.Property bitter cold, taste are micro-sweet.GUIXIN, liver, spleen channel, effect of tool heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema, for laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, jaundice due to damp-heat etc.
Echinacea effect: Echinacea another name Echinacea Species, Echinacea purpurea Moench, containing polysaccharide, flavone, caffeinic derivant, quintessence oil, polyacetylene, alkylamine and alkaloid, have immunostimulation, reduce inflammation, and help body fight antibacterial and virus.Related tests shows to use Echinacea feeding animals, can improve the phagocytic activity of neutrophil cell and the quantity of periphery lymphocyte, the immunocompetence of effective stimulus animal body.
Radix Astragali effect: the Radix Astragali another name Radix Astragali, continuous stilbene.Sweet in the mouth, slightly warm in nature, return liver, spleen, lung, kidney channel.Containing the various trace elements such as Saponin, flavone, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, there is enhancing human body immunity function, protect the liver, diuresis, blood pressure lowering, defying age, anti-hypoxia, radioprotective, anti-stress, low temperature resistant and high temperature resistant effect.The Radix Astragali has stronger antibacterial action to dysentery bacterium, Hemolytic streptococcus etc. in vitro.
Rhizoma Cimicifugae effect: Rhizoma Cimicifugae another name Radix Longan, bamboo stick used as a toy horse, acrid in the mouth, micro-sweet, be slightly cold, return lung, spleen, stomach, large intestine channel.Rhizoma Cimicifugae is containing cimicifugine, salicylic acid, tannin, resin, caffeic acid, ferulic acid, Hesperetic acid, cimicifugoside etc.Inhibitory action is in various degree had to Bacillus typhi, escherichia coli, dysentery bacterium; In addition also there is calmness, anticonvulsant action, antipyretic cooling effect.Tool delivers rash, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy, for laryngopharynx swelling and pain, and proctoptosis etc.
Radix Glycyrrhizae effect: Radix Glycyrrhizae another name Glycyrrhizae, state are old, Herba Hedyotis cantonensis, leather and fur, and property is put down, and sweet in the mouth, returns 12 warps.Radix Glycyrrhizae mainly containing the composition such as glycyrrhizic acid, glycyrrhizin, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide, there is antiulcer, promote pancreatic secretion, protect the liver, blood fat reducing, adjustment macrophage the effect such as phagocytic function; Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, maintenance water-electrolyte metabolism balance etc.; Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, cushion toxicity, strong.
Prescription foundation of the present invention: piglet pujos blancos is that suckling pig common bacteria is sick, after piglet birth during 15-21 days because breast milk is not enough, feed quality is poor, intestine of young pigs dominant microflora is not set up and ehec infection completely, make piglet diarrhea, dehydration, poor growth, severe patient death, therefore in treatment, should with anti-inflammation, spleen invigorating dysentery relieving, enhancing immunity for the rule for the treatment of.Herba Andrographis in prescription, Herba Euphorbiae Humifusae, Herba Plantaginis, Radix Gentianae, antibacterial and bacteriostasis that Herba Hedyotidis Diffusae tool is stronger, Rhizoma Cimicifugae delivers rash, heat-clearing and toxic substances removing, ascending up spleen-Qi and Yang, and Echinacea improves body's immunity, Radix Glycyrrhizae sweet temperature QI invigorating and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription.In prescription all medicine phases and, play effect of anti-inflammation, YIN nourishing and the production of body fluid promoting, spleen invigorating dysentery relieving, ascending up spleen-Qi and Yang, enhancing immunologic function altogether, be applicable to piglet pujos blancos.
The present invention treats the Chinese herbal medicament oral liquid of piglet pujos blancos, is on the basis of carrying out a large amount of practical application, according to traditional medicine ancient prescription, forms, have good therapeutic effect to piglet pujos blancos in conjunction with modern popular disease, the screening of nosetiology theory.
Detailed description of the invention
The invention will be further described in conjunction with the embodiments.
Embodiment:
1, difference weighting raw materials (decoction pieces): Herba Andrographis 250g, Herba Euphorbiae Humifusae 190g, Herba Plantaginis 125g, Radix Gentianae 125g, Herba Hedyotidis Diffusae 95g, Echinacea 95g, Radix Astragali 60g, Rhizoma Cimicifugae 30g, Radix Glycyrrhizae 30g;
2, above-mentioned raw materials medicine is ground into coarse powder respectively;
3, get above-mentioned eight taste Chinese herbal medicine coarse powder, decoct after 8000 mL that add water soak 1h, water opens rear slow fire boiling 30min; Filter to obtain first-time filtrate, medicinal residues add water again at every turn 6000 mL decoct secondaries, each 20min, filter respectively secondary and three filtrates; Merge three filtrates, be concentrated into about 900 mL;
4, by concentrated solution obtained above, add 0.05% sodium benzoate as antiseptic, add water to 1000mL, stir evenly, filter, fill, sterilizing, obtains Chinese herbal medicament oral liquid of the present invention.
Some test situation utilizing Chinese herbal medicament oral liquid of the present invention to carry out are as follows:
1, Chinese herbal medicament oral liquid of the present invention is to escherichia coli drug sensitive test
Choose clinical trouble piglet pujos blancos case, through being separated, identifying pathogen as escherichia coli O38.Get a certain amount of Chinese herbal medicament oral liquid of the present invention, every mL is containing crude drug 1g, and sterilizing, subpackage, 4 DEG C save backup.The escherichia coli O38 of clinical separation is first inoculated in flat board, after cultivating 18 h, selects colonies typical and be inoculated in 5 mL meat soups in 37 DEG C, after cultivating 18 h in 37 DEG C, bacterium liquid, than turbid, is diluted to 10 with meat soup by 0.5 Maxwell unit norm opacity tube
5cFU/mL, for subsequent use.
Medicament sensitivity test: adopt plate punch method, add 1g/mL Chinese herbal medicament oral liquid of the present invention in hole, is not advisable outside overfolw hole to fill it up with.Choose the generally acknowledged drug sensitive test of the good three kinds of antibiotic of escherichia coli effect as norfloxacin (1 μ g/mL), kanamycin sulfate (1 μ g/mL), neomycin (1 μ g/mL) is compared, be placed in 37 DEG C of constant incubators and cultivate 24 h, measure antibacterial circle diameter, the drug sensitive test of often kind of medicine in triplicate.Criterion: according to " pharmacology of Chinese materia medica " standard with " U.S. clinical Laboratory Standard institute version in 2005 is about drug sensitive test standardization ", namely bacteriostatic diameter >=20 mm is extremely quick, 20 mm> bacteriostatic diameter >=15 mm are Gao Min, 15 mm> bacteriostatic diameter >=10 mm are quick in being, 10 below mm are hypoallergenic.
Chinese herbal medicament oral liquid medicament sensitivity test of the present invention the results are shown in Table 1.
The drug sensitive test result mm of table 1 Chinese herbal medicament oral liquid of the present invention
| Medicine | Escherichia coli O38 |
| Norfloxacin | 16.0±0.5 |
| Kanamycin sulfate | 17.3±0.3 |
| Neomycin | 18.5±0.5 |
| Chinese herbal medicament oral liquid of the present invention | 23.5±0.8 |
Table 1 shows, and to escherichia coli O38, Chinese herbal medicament oral liquid of the present invention is extremely quick, and bacteriostatic diameter reaches 23.5 mm, and norfloxacin, kanamycin sulfate and neomycin are Gao Min.Drug sensitivity test shows, the inhibitory action of Chinese herbal medicament oral liquid of the present invention to escherichia coli O38 is the most responsive, and neomycin takes second place, and kanamycin sulfate, norfloxacin are slightly secondary.Result shows, Chinese herbal medicament oral liquid of the present invention should as first-selection in the practice for the treatment of piglet pujos blancos.
2, the clinical trial of natural infection piglet pujos blancos:
For " DLY " tri-crossbreeding that examination pig is pig farm, Funing County, Hebei province, select 40 age in days 20-25 ages in days and suffer from Hakuri pig, be divided into 4 groups at random, often organize 10.Experimental period 7d.Sick pig, by recommended dose administration, calculates cure rate, and the cure rate of each group piglet is in table 2.
The cure rate (head, %) of piglet respectively organized by table 2
| Group | Dosage | Sample size | Diarrhoea number | Cure rate | Death toll | Mortality rate |
| Ith group | Not medication group | 10 | 8 | 0 | 1 | 10 |
| IIth group | Kanamycin sulfate 10mg/kg, injection, day 2 times | 10 | 2 | 80 | 0 | 0 |
| IIIth group | Neomycin 2.5mg/ kg, injection, day 2 times | 10 | 3 | 70 | 0 | 0 |
| IVth group | Oral liquid group 10mL/ head of the present invention, oral, day 2 times | 10 | 1 | 90 | 0 |
As shown in Table 2, the 5d of test, the Ith group dead 1, all the other each group at duration of test all without dead, after off-test, the IIth group, the IIIth group and the IVth group of cure rate respectively 80%, 70% and 90%; Oral liquid of the present invention can improve the cure rate of piglet pujos blancos, and is slightly better than commercially available antibiotic as kanamycin sulfate, neomycin.
Claims (2)
1. treat the Chinese herbal medicament oral liquid of piglet pujos blancos for one kind, it is characterized in that it is made up of the crude drug of following weight parts: Herba Andrographis 8-10 part, Herba Euphorbiae Humifusae 6-8 part, Herba Plantaginis 3-4 part, Radix Gentianae 3-4 part, Herba Hedyotidis Diffusae 2-4 part, Echinacea 2-3 part, Radix Astragali 2-3 part, Rhizoma Cimicifugae 1-2 part, Radix Glycyrrhizae 1-2 part.
2. the Chinese herbal medicament oral liquid for the treatment of piglet pujos blancos according to claim 1, is characterized in that it is made up of the crude drug of following weight parts: Herba Andrographis 8 parts, Herba Euphorbiae Humifusae 6 parts, Herba Plantaginis 4 parts, Radix Gentianae 4 parts, Herba Hedyotidis Diffusae 3 parts, Echinacea 3 parts, the Radix Astragali 2 parts, Rhizoma Cimicifugae 1 part, 1 part, Radix Glycyrrhizae.
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| CN115025149B (en) * | 2022-07-28 | 2023-10-10 | 河北科技师范学院 | Chinese herbal medicine composition for promoting growth and preventing diseases of cynoglossus semilaevis and preparation method thereof |
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| CN1704085A (en) * | 2004-06-04 | 2005-12-07 | 成都地奥制药集团有限公司 | Pharmaceutical composition with immunoregulation function and method for preparing the same |
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| CN1704085A (en) * | 2004-06-04 | 2005-12-07 | 成都地奥制药集团有限公司 | Pharmaceutical composition with immunoregulation function and method for preparing the same |
Non-Patent Citations (3)
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| 中草药治疗仔猪白痢病筛选试验初报;江西省中兽医研究所;《中兽医科技资料》;19741231(第3期);第2-7，11页 * |
| 升麻的临床应用近况;王彩华;《中医药信息》;19911231(第1期);第44-45页 * |
| 车前草治腹泻;李玲;《中国民间疗法》;20030331;第11卷(第3期);第63页 * |
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