CN103495187B - Type-B ultrasonic traditional Chinese medicinal gastroenterography assistant and method for preparing same - Google Patents
Type-B ultrasonic traditional Chinese medicinal gastroenterography assistant and method for preparing same Download PDFInfo
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Abstract
The invention provides a type-B ultrasonic traditional Chinese medicinal gastroenterography assistant and a method for preparing the same. The traditional Chinese medicinal gastroenterography assistant comprises egg shells, asteroid, clam shells, elaeagnus pungens, hairyvein agrimony, licorice, calcined dragon bone, hyperforin, purple lythrum herbs, kadsura longipedunculata, rhubarb, roots of yellow Himalayan raspberry, cornu cervi degelatinatum, red umbilicaria, hop, amomum aromaticum, wampee, rhizoma nardostachyos, areca peels, pugionium and curcuma zedoaria. The type-B ultrasonic traditional Chinese medicinal gastroenterography assistant and the method have the advantages that the type-B ultrasonic traditional Chinese medicinal gastroenterography assistant is safe in use, free of allergic reaction, short in examination time, high in developing rate, convenient to use and low in cost and is painless, noninvasive and non-toxic, a novel technology and a novel method are provided for early and accurate diagnosis of diseases, a powerful basis for clinical diagnosis is provided, the type-B ultrasonic traditional Chinese medicinal gastroenterography assistant is perfect and novel, and a process for manufacturing the type-B ultrasonic traditional Chinese medicinal gastroenterography assistant is simple and practical.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, relate in particular to a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof.
Background technology
Ultrasonoscopy diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three effects greatly to material: the one, mechanism, because ultrasonic energy is huge, often makes material particle do altofrequency mechanical vibration, thus produce smash, cohesion, agitation effects.The 2nd, warm-heat effect, ul-trasonic irradiation is when material, and its energy is absorbed by material, thereby makes material temperature rising phenomenon.The 3rd, cavitation, ul-trasonic irradiation is on liquid time, in the region of liquid internal stress weakness (if any microcosmic bubble etc.) because acoustic pressure great variety becomes sparse, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.This cavity time of staying is not long, collapse again under huge acoustic pressure effect, and because cavity forms and disappears, producing a large amount of bubbles will affect ultrasonic diagnosis effect, so eliminating bubble is the Main Function of ultrasonic contrast agent.
At present, for B ultrasonic gastrointestinal contrast agent, prior art has been recorded the contrast agent that the 100 order fine powders by Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20% are mixed with, gastrointestinal disease is had to convergence, antacid effect, but weak point is patient takes that to produce strong echo luminous point after contrast agent not enough, reflecting effect is not good, and coat of the stomach level shows unintelligible; Patient takes after this contrast agent, and gastric acid strong reaction has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, to gastrorrhagia patient, can not apply this contrast agent.
Another kind of fast ultrasonic image-developing liquor preparation method is that bitter bucket, MIXIANG, abdomen floss, Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, sucrose are mixed in proportion by decocting, distill, concentrating, and makes imaging liquid, and good video picture rate reaches 87%.In this prescription, used bitter bucket, taste is extremely bitter, thereby improves mouthfeel with sucrose, and sucrose enters the easy bubble that produces in gastric juice, thereby imaging results is had to impact, and in addition, this invention product is without therapeutical effect.
Summary of the invention
Technical problem to be solved by this invention is, utilize the traditional theory of Chinese medical science of China, a kind of novel use safety, avirulence are provided, have no side effect, the review time is short, video picture rate is high, Chinese medicine gastrointestinal contrast agent for B ultrasonic easy to use and preparation method thereof.
In order to solve above-mentioned technology, ask, the invention provides a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic, described Chinese medicine gastrointestinal contrast agent comprises following raw medicinal material: Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Herba Agrimoniae, Radix Glycyrrhizae, Os Draconis (calcined), Herba Hyperici perforati, Herba Lythri Salicariae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), Flos lupuli (Flos Humuli Lupuli), Fructus Amomi subulati, Fructus clausenae lansii, Radix Et Rhizoma Nardostachyos, Pericarpium Arecae, Herba Pugionii Cornuti and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be: 30～40 parts of Ovum Gallus domesticus crustas, 20～30 parts of starfishes, 30～40 parts of Concha Meretricis Seu Cyclinaes, 20～30 parts of Fructus Elaeagni, 10～20 parts of Herba Agrimoniaes, 15～30 parts, Radix Glycyrrhizae, 10～20 parts of Os Draconis (calcined)s, 5～15 parts of Herba Hyperici perforatis, 5～15 parts of Herba Lythri Salicariae, 10～20 parts of Fructus Schisandrae Sphenantheraes, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix rubi elliptici, 15～25 parts of Cornu Cervi Degelatinatums, 15～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 20～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 10～20 parts of Fructus Amomi subulati, 25～35 parts of Fructus clausenae lansii, 20～30 parts of Radix Et Rhizoma Nardostachyos, 5～15 parts of Pericarpium Arecae, 20～30 parts of 10～20 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can also be: 35～40 parts of Ovum Gallus domesticus crustas, 25～30 parts of starfishes, 30～35 parts of Concha Meretricis Seu Cyclinaes, 20～25 parts of Fructus Elaeagni, 10～15 parts of Herba Agrimoniaes, 20～30 parts, Radix Glycyrrhizae, 15～20 parts of Os Draconis (calcined)s, 10～15 parts of Herba Hyperici perforatis, 5～10 parts of Herba Lythri Salicariae, 15～20 parts of Fructus Schisandrae Sphenantheraes, 10～15 parts of Radix Et Rhizoma Rhei, 8～12 parts of Radix rubi elliptici, 15～20 parts of Cornu Cervi Degelatinatums, 20～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 25～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 15～20 parts of Fructus Amomi subulati, 25～30 parts of Fructus clausenae lansii, 20～25 parts of Radix Et Rhizoma Nardostachyos, 5～10 parts of Pericarpium Arecae, 20～25 parts of 10～15 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be also: 24 parts of 40 parts of Ovum Gallus domesticus crustas, 26 parts of starfishes, 33 parts of Concha Meretricis Seu Cyclinaes, 22 parts of Fructus Elaeagni, 13 parts of Herba Agrimoniaes, 28 parts, Radix Glycyrrhizae, 17 parts of Os Draconis (calcined)s, 13 parts of Herba Hyperici perforatis, 8 parts of Herba Lythri Salicariae, 18 parts of Fructus Schisandrae Sphenantheraes, 12 parts of Radix Et Rhizoma Rhei, 11 parts of Radix rubi elliptici, 15 parts of Cornu Cervi Degelatinatums, 24 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 29 parts of Flos lupuli (Flos Humuli Lupuli)s, 15 parts of Fructus Amomi subulati, 27 parts of Fructus clausenae lansii, 21 parts of Radix Et Rhizoma Nardostachyos, 8 parts of Pericarpium Arecae, 12 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be again: 22 parts of 37 parts of Ovum Gallus domesticus crustas, 28 parts of starfishes, 35 parts of Concha Meretricis Seu Cyclinaes, 24 parts of Fructus Elaeagni, 11 parts of Herba Agrimoniaes, 24 parts, Radix Glycyrrhizae, 19 parts of Os Draconis (calcined)s, 12 parts of Herba Hyperici perforatis, 6 parts of Herba Lythri Salicariae, 15 parts of Fructus Schisandrae Sphenantheraes, 14 parts of Radix Et Rhizoma Rhei, 9 parts of Radix rubi elliptici, 17 parts of Cornu Cervi Degelatinatums, 21 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 26 parts of Flos lupuli (Flos Humuli Lupuli)s, 18 parts of Fructus Amomi subulati, 30 parts of Fructus clausenae lansii, 23 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Pericarpium Arecae, 13 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, when the dosage form of described Chinese medicine gastrointestinal contrast agent is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material of Chinese medicine gastrointestinal contrast agent, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 90%～95%, and reflux 2～4 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 5～8 times of described medicinal residues quality is 80%～85% again, and reflux 3～5 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.2～0.4 times of its quality, 0.02～0.06 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
Wherein, when the dosage form of described Chinese medicine gastrointestinal contrast agent is powder, its preparation method comprises the following steps:
The first step, Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Os Draconis (calcined), Herba Hyperici perforati and Herba Lythri Salicariae are mixed in described ratio, use the dissolve with ethanol that the determining alcohol of 3～5 times with respect to the mixture quality obtaining is 90%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～85% of 5～8 times of the mixture quality obtaining again, and reflux was extracted after 3～5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.5～1.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 6 times of resin column volumes, with the determining alcohol of 8 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, Herba Agrimoniae, Radix Glycyrrhizae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum and Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 4～8 times of the mixture quality obtaining, heating and refluxing extraction 2～4 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.26～1.29, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 4～6 times with respect to the mixture quality obtaining, and heating decocts 3～4 hours, filters; Filtering residue is used to the water dissolution of 3～5 times with respect to the mixture quality obtaining again, and heating decocts 2～3 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 160～200 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains the powder of described Chinese medicine gastrointestinal contrast agent.
Beneficial effect of the present invention: the Chinese medicine contrast agent that B ultrasonic of the present invention is used uses safety, no pain, without wound, avirulence, without anaphylaxis, review time is short, video picture rate is high, easy to use, cost is low, for the early stage of disease correctly diagnosed a kind of new technique, new method is provided, for clinical diagnosis provides strong foundation, be comparatively desirable novel contrast agent, and preparation technology is simple, practical.
The specific embodiment
The invention provides a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic, described Chinese medicine gastrointestinal contrast agent comprises following raw medicinal material: Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Herba Agrimoniae, Radix Glycyrrhizae, Os Draconis (calcined), Herba Hyperici perforati, Herba Lythri Salicariae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), Flos lupuli (Flos Humuli Lupuli), Fructus Amomi subulati, Fructus clausenae lansii, Radix Et Rhizoma Nardostachyos, Pericarpium Arecae, Herba Pugionii Cornuti and Rhizoma Curcumae.
The pharmacology of various raw medicinal materials is as follows:
Ovum Gallus domesticus crusta: lightly seasoned; Property is put down.Return stomach; Kidney channel.Convergence; Antacid; Bone strengthening; Hemostasis; Improving eyesight.Main gastric abscess; Regurgitation; Acid regurgitation; Rickets of child; Various hemorrhage; The raw nebula film of order; Chancre pox poison.
Starfish: taste becomes; Property is put down.Return liver; Stomach warp.Checking hyperfunction of the liver for relieving convulsion; Anti-acid and regulating stomach; Heat-clearing and toxic substances removing.Main epilepsy; Stomachache acid regurgitation; Thyromegaly; Otitis media.
Concha Meretricis Seu Cyclinae: bitter, one-tenth, cold.Return lung, kidney, stomach warp.Removing heat-phlegm, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For phlegm-fire cough, pain in chest and hypochondrium, sputum mixed with blood, scrofula goiter, stomachache acid regurgitation; External treatment eczema, scalds.
Fructus Elaeagni: acid; Puckery; Flat.Return lung; Stomach; Large intestine channel; Astringing to arrest diarrhea; Strengthening the spleen to promote digestion; Relieving cough and asthma; Hemostasis.Main having loose bowels; Dysentery; Inappetence; Dyspepsia; Cough and asthma; Metrorrhagia; Hemorrhoid hematochezia.
Herba Agrimoniae: bitter, puckery, flat.GUIXIN, Liver Channel.Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, cloudy overworked leukorrhagia.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Os Draconis: sweet puckery; Flat; Nontoxic.GUIXIN; Liver; Kidney; Large intestine channel.Tranquillizing the mind by relieving convulsion; Suppressing the hyperactive liver and subsiding YANG; Astringent or styptic treatment for spontaneous sweating; Convergence.Main infantile convulsion is demented; Severe palpitation; Insomnia forgetfulness; Have a dizzy spell; Spontaneous sweating; The seminal emission enuresis; Bleeding not during menses; Chronic diarrhea chronic dysentery; Ulcer does not close up and eczema for a long time.Os Draconis (calcined): get the Os Draconis of outwash, forge and be popular on smokeless stove fire or in crucible, take out, cool, pulverize.
Herba Hyperici perforati: bitter in the mouth; Puckery; Property is put down; Return Liver Channel.Astringing to arrest bleeding; Regulating menstruation lactogenesis; Heat-clearing and toxic substances removing; Dampness removing.Main spitting of blood; Spit blood; Discharging fresh blood stool; Metrorrhagia; Traumatic hemorrhage; Menstruation is fried and is adjusted; Breast woman agalactia; Jaundice; Have sore throat; Conjunctival congestion and swelling pain; Urinary tract infection; The raw skin ulcer of mouth and nose; Carbuncle furuncle and phyma poison; Burn and scald.
Herba Lythri Salicariae: bitter in the mouth; Cold in nature.Return large intestine, Liver Channel.Heat-clearing and toxic substances removing; Astringing to arrest bleeding.Main dysentery; Have loose bowels; Have blood in stool; Metrorrhagia; Skin infection festers; Spit blood; Epistaxis; Traumatic hemorrhage.
Fructus Schisandrae Sphenantherae: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Et Rhizoma Rhei: hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.For heat in blood, there is stasis of blood hemorrhage.
Radix rubi elliptici: become acid; Flat; Nontoxic.Return lung; Kidney channel.Expelling wind and removing dampness; Heat-clearing and toxic substances removing; Astringing to arrest diarrhea.Main air pain of dampness syndrome, laryngopharynx swelling and pain, scrofula, dysentery, diarrhoea, discharging fresh blood stool, spits blood.
Cornu Cervi Degelatinatum: become temperature.Return liver, kidney channel.Warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.
Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.): micro-hardship; Property is put down.Return stomach warp.The stomach invigorating of regulating the flow of vital energy; Diuretic relieving distension.Main dyspepsia; Stomachache; Dysentery; Infantile malnutrition.
Flos lupuli (Flos Humuli Lupuli): hardship; Slightly cool in nature.Return liver; Stomach warp.Invigorating the stomach and promoting digestion; Inducing diuresis to remove edema; Anti-consumptive disease antiinflammatory.Main dyspepsia; Abdominal distention; Edema; Cystitis; Pulmonary tuberculosis; Cough; Insomnia; Leprosy.
Fructus Amomi subulati: acrid in the mouth; Warm in nature.Return lung; Liver; Stomach; Large intestine channel.Cold expelling circulation of qi promoting, invigorating the stomach and promoting digestion.Main abdominal distention; Accumulation of food in the stomach and intes tine due to indigestion; Lung cold cough.
Fructus clausenae lansii: pungent; Sweet; Acid; Temperature.Return lung; Stomach warp.Circulation of qi promoting; Help digestion; Reduce phlegm.Staple food amasss distension; Epigastric pain; Colic; Phlegm retention cough with asthma.
Radix Et Rhizoma Nardostachyos: acrid, sweet, warm.Return spleen, stomach warp.Regulating QI to relieve pain, relieving stagnation and activating the spleen.For distension and fullness in the abdomen, inappetence, vomiting; External treatment toothache, swelling of the feet.
Pericarpium Arecae: pungent, tepor.Return spleen, stomach, large intestine, small intestine meridian.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, defecate not well, and edema distension, beriberi edema, dysuria.
Herba Pugionii Cornuti: pungent; Temperature.GUIXIN; Lung; Stomach warp.Circulation of qi promoting; Pain relieving; Help digestion; Removing toxic substances.Main fullness and distention in the chest and hypochondrium; Dyspepsia; Alimentary toxicosis.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be: 30～40 parts of Ovum Gallus domesticus crustas, 20～30 parts of starfishes, 30～40 parts of Concha Meretricis Seu Cyclinaes, 20～30 parts of Fructus Elaeagni, 10～20 parts of Herba Agrimoniaes, 15～30 parts, Radix Glycyrrhizae, 10～20 parts of Os Draconis (calcined)s, 5～15 parts of Herba Hyperici perforatis, 5～15 parts of Herba Lythri Salicariae, 10～20 parts of Fructus Schisandrae Sphenantheraes, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix rubi elliptici, 15～25 parts of Cornu Cervi Degelatinatums, 15～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 20～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 10～20 parts of Fructus Amomi subulati, 25～35 parts of Fructus clausenae lansii, 20～30 parts of Radix Et Rhizoma Nardostachyos, 5～15 parts of Pericarpium Arecae, 20～30 parts of 10～20 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can also be: 35～40 parts of Ovum Gallus domesticus crustas, 25～30 parts of starfishes, 30～35 parts of Concha Meretricis Seu Cyclinaes, 20～25 parts of Fructus Elaeagni, 10～15 parts of Herba Agrimoniaes, 20～30 parts, Radix Glycyrrhizae, 15～20 parts of Os Draconis (calcined)s, 10～15 parts of Herba Hyperici perforatis, 5～10 parts of Herba Lythri Salicariae, 15～20 parts of Fructus Schisandrae Sphenantheraes, 10～15 parts of Radix Et Rhizoma Rhei, 8～12 parts of Radix rubi elliptici, 15～20 parts of Cornu Cervi Degelatinatums, 20～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 25～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 15～20 parts of Fructus Amomi subulati, 25～30 parts of Fructus clausenae lansii, 20～25 parts of Radix Et Rhizoma Nardostachyos, 5～10 parts of Pericarpium Arecae, 20～25 parts of 10～15 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be also: 24 parts of 40 parts of Ovum Gallus domesticus crustas, 26 parts of starfishes, 33 parts of Concha Meretricis Seu Cyclinaes, 22 parts of Fructus Elaeagni, 13 parts of Herba Agrimoniaes, 28 parts, Radix Glycyrrhizae, 17 parts of Os Draconis (calcined)s, 13 parts of Herba Hyperici perforatis, 8 parts of Herba Lythri Salicariae, 18 parts of Fructus Schisandrae Sphenantheraes, 12 parts of Radix Et Rhizoma Rhei, 11 parts of Radix rubi elliptici, 15 parts of Cornu Cervi Degelatinatums, 24 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 29 parts of Flos lupuli (Flos Humuli Lupuli)s, 15 parts of Fructus Amomi subulati, 27 parts of Fructus clausenae lansii, 21 parts of Radix Et Rhizoma Nardostachyos, 8 parts of Pericarpium Arecae, 12 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent can be again: 22 parts of 37 parts of Ovum Gallus domesticus crustas, 28 parts of starfishes, 35 parts of Concha Meretricis Seu Cyclinaes, 24 parts of Fructus Elaeagni, 11 parts of Herba Agrimoniaes, 24 parts, Radix Glycyrrhizae, 19 parts of Os Draconis (calcined)s, 12 parts of Herba Hyperici perforatis, 6 parts of Herba Lythri Salicariae, 15 parts of Fructus Schisandrae Sphenantheraes, 14 parts of Radix Et Rhizoma Rhei, 9 parts of Radix rubi elliptici, 17 parts of Cornu Cervi Degelatinatums, 21 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 26 parts of Flos lupuli (Flos Humuli Lupuli)s, 18 parts of Fructus Amomi subulati, 30 parts of Fructus clausenae lansii, 23 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Pericarpium Arecae, 13 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
Wherein, when the dosage form of described Chinese medicine gastrointestinal contrast agent is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material of Chinese medicine gastrointestinal contrast agent, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 90%～95%, and reflux 2～4 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 5～8 times of described medicinal residues quality is 80%～85% again, and reflux 3～5 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.2～0.4 times of its quality, 0.02～0.06 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
Wherein, when the dosage form of described Chinese medicine gastrointestinal contrast agent is powder, its preparation method comprises the following steps:
The first step, Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Os Draconis (calcined), Herba Hyperici perforati and Herba Lythri Salicariae are mixed in described ratio, use the dissolve with ethanol that the determining alcohol of 3～5 times with respect to the mixture quality obtaining is 90%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80%～85% of 5～8 times of the mixture quality obtaining again, and reflux was extracted after 3～5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.5～1.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 6 times of resin column volumes, with the determining alcohol of 8 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, Herba Agrimoniae, Radix Glycyrrhizae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum and Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 4～8 times of the mixture quality obtaining, heating and refluxing extraction 2～4 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.26～1.29, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 4～6 times with respect to the mixture quality obtaining, and heating decocts 3～4 hours, filters; Filtering residue is used to the water dissolution of 3～5 times with respect to the mixture quality obtaining again, and heating decocts 2～3 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 160～200 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains the powder of described Chinese medicine gastrointestinal contrast agent.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1: tablet prepared by the present invention
Get Ovum Gallus domesticus crusta 370g, starfish 280g, Concha Meretricis Seu Cyclinae 350g, Fructus Elaeagni 240g, Herba Agrimoniae 110g, Radix Glycyrrhizae 240g, Os Draconis (calcined) 190g, Herba Hyperici perforati 120g, Herba Lythri Salicariae 60g, Fructus Schisandrae Sphenantherae 150g, Radix Et Rhizoma Rhei 140g, Radix rubi elliptici 90g, Cornu Cervi Degelatinatum 170g, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 210g, Flos lupuli (Flos Humuli Lupuli) 260g, Fructus Amomi subulati 180g, Fructus clausenae lansii 300g, Radix Et Rhizoma Nardostachyos 230g, Pericarpium Arecae 60g, Herba Pugionii Cornuti 130g and Rhizoma Curcumae 220g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material of Chinese medicine gastrointestinal contrast agent, adds the ethanol that the determining alcohol with respect to 4 times of mixture qualities is 95%, and reflux 3 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 7 times of described medicinal residues quality is 85% again, and reflux 5 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 3 hours, pulverizes, and sieves, and obtains 400 object micropowders;
The 3rd step, the micropowders that second step is obtained, adds microcrystalline Cellulose with respect to 0.3 times of its quality, 0.04 times of lactose, the starch of 0.25 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.035 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
Embodiment 2: powder prepared by the present invention
Get Ovum Gallus domesticus crusta 400g, starfish 260g, Concha Meretricis Seu Cyclinae 330g, Fructus Elaeagni 220g, Herba Agrimoniae 130g, Radix Glycyrrhizae 280g, Os Draconis (calcined) 170g, Herba Hyperici perforati 130g, Herba Lythri Salicariae 80g, Fructus Schisandrae Sphenantherae 180g, Radix Et Rhizoma Rhei 120g, Radix rubi elliptici 110g, Cornu Cervi Degelatinatum 150g, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 240g, Flos lupuli (Flos Humuli Lupuli) 290g, Fructus Amomi subulati 150g, Fructus clausenae lansii 270g, Radix Et Rhizoma Nardostachyos 210g, Pericarpium Arecae 80g, Herba Pugionii Cornuti 120g and Rhizoma Curcumae 240g;
Its preparation method comprises the following steps:
The first step, Ovum Gallus domesticus crusta, starfish, Concha Meretricis Seu Cyclinae, Fructus Elaeagni, Os Draconis (calcined), Herba Hyperici perforati and Herba Lythri Salicariae are mixed in described ratio, use the dissolve with ethanol that the determining alcohol of 5 times with respect to the mixture quality obtaining is 90%, reflux was extracted after 3 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 80% of 8 times of the mixture quality obtaining again, and reflux was extracted after 5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.7g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 6 times of resin column volumes, with the determining alcohol of 8 times of resin column volumes, be 95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, Herba Agrimoniae, Radix Glycyrrhizae, Fructus Schisandrae Sphenantherae, Radix Et Rhizoma Rhei, Radix rubi elliptici, Cornu Cervi Degelatinatum and Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 7 times of the mixture quality obtaining, heating and refluxing extraction 3 times, each time extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃, relative density is 1.28, the mastic after concentrated is dried to powder with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 5 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 4 times with respect to the mixture quality obtaining again, and heating decocts 2 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 200 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains the powder of described Chinese medicine gastrointestinal contrast agent.
Toxicity test:
Acute toxicity test: in distilled water, respectively give 4 group white mice feedings dispensings with 60 times, 110 times, 170 times and 260 times of clinical consumption per day with the tablet dissolved of the embodiment of the present invention 1 preparation, observe 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test: by the tablet of the embodiment of the present invention 1 preparation by 9.47,19.62 and 41.57g crude drug/kg be dissolved in water, 3 groups of mices are distinguished to continuous uses 16 weeks, every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of 3 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Pharmacodynamic experiment:
One, the impact of the tablet of Chinese medicine contrast agent of the present invention on small intestine movement of mice motion
1, test material
1.1 experimental animals: 80 of ICR mices, male and female half and half, body weight 18～24g.
1.2 trial drugs:
1.2.1 the tablet of the embodiment of the present invention 1.By Chinese medicine gastrointestinal contrast agent tablet of the present invention with distilled water be dissolved into 0.534,0.267, the medicinal liquid of 0.134g crude drug/ml is stand-by.
1.2.2 atropine sulfate injection, becomes 0.01mg/ml solution with normal saline dilution before using.
1.2.3 active carbon; Arabic gum (making containing 10% Radix Acaciae senegalis the charcoal of 5% active carbon end distilled water suspension).
1.3 testing equipments: T-500 electronic balance, PL203 precise electronic balance.
2, test method
Select 18～24g body weight mice, by the method for body weight random stratified, be divided into 5 groups, be i.e. blank group, atropine sulfate group, the high, medium and low dosage group of Chinese medicinal tablet of the present invention.Every group 16, male and female half and half.Blank group and atropine sulfate group gavage distilled water 30ml/kg, high, medium and low dosage group is gavage Chinese medicinal tablet medicinal liquid 16,8 of the present invention, 4g crude drug/kg respectively, 1 time/d.After gavage 7 days, in experiment at dusk fasting the previous day, can't help water 18h, after the 8th day last administration 1h (atropine diluent 0.1mg/kg5min), each only organizes gavage charcoal end suspension 0.2ml/.After 20min, put to death animal; open the separated mesentery in abdominal cavity; see that coat of the stomach clear layer is visible, and after under these contrast agent clothes, all mucosas of stomach are played a protective role; in ultrasound display screen, can seeing gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature etc., to locate video picture obvious; each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas clear display, clip front end is to pylorus; rear end, to the intestinal tube of ileocecus, is placed on pallet.Gently small intestinal is put into straight line, measures Length of intestine as " small intestinal total length ".Distance from pylorus to prepared Chinese ink forward position is as " distance that prepared Chinese ink advances at enteral ".Formula calculates prepared Chinese ink propelling rate: prepared Chinese ink propelling rate=(prepared Chinese ink is in enteral advance distance/small intestinal total length) * 100%.
3, result of the test
With the comparison of blank group, atropine sulfate group charcoal end forward position propelling rate obviously reduces (P < 0.05), and the gastric peristalsis of Chinese medicinal tablet of the present invention is obviously hyperfunction, with the comparison of blank group, can obviously promote gastrointestinal motility function.In Table 1.
The impact of the tablet of table 1 Chinese medicine contrast agent of the present invention on the hyperfunction mouse small intestine motion of intestinal propulsion
| Group | Number of cases | Forward position propelling rate % |
| Blank group | 16 | 40.82±4.07 |
| Atropine sulfate group | 16 | 54.27±8.62*** |
| Tablet 4g crude drug/kg of the present invention | 16 | 69.05±11.28** |
| Tablet 8g crude drug/kg of the present invention | 16 | 76.52±10.49 |
| Tablet 16g crude drug/kg of the present invention | 16 | 87.93±11.36 |
Note: with blank group comparison: P < 0.05, with blank group comparison: * * P < 0.01, * * * P < 0.001.
Conclusion (of pressure testing): motion has obvious inhibitory action to the low dose group of the tablet 4g crude drug/kg of Chinese medicine contrast agent of the present invention to gastrointestinal motility hyperfunctioning mouse small intestine, increases with dosage, shows the trend that promotes bowel movement effect.This test is from having studied the tablet in treatment gastropathy of Chinese medicine contrast agent of the present invention at aspects such as body and in vitro function of intestinal canal impact, stopping leak, antibacterial, the anti-immunity of antiinflammatory, the Pharmacological Mechanism of enteritis, dysentery, can promote gastrointestinal motility, digestion, absorption, and have certain bacteriostasis, and show the anti-immunization of stronger antiinflammatory.
Two, In vitro Bactericidal Experiments
Adopt agar doubling dilution to measure the present invention to the minimum inhibitory concentration of common pathogen (MIC).Tested bacterium is inoculated in MH broth bouillon, cultivates after 18 hours for 35 ℃, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 108CFU/ml.With physiological saline solution, dilute 1:10 (the about 107CFU/ml of bacteria containing amount).Get respectively the medicinal liquid 2ml having diluted for series concentration and add in the flat board that performs labelling, then get the MH agar culture medium 18ml that has been chilled to 50 ℃ of left and right after thawing be added to dull and stereotyped in (medicine: agar=1:9), medicine and culture medium are fully mixed.Medicine ultimate density is respectively 200,100,50 ... 0.78,0.39mg/ml.The bacteria suspension having prepared is inoculated on pastille flat board with inoculating loop, and in 18 hours observed results of 35 ℃ of cultivations, the lowest drug concentration that colony growth is suppressed is completely for this medicine is to detecting the MIC of bacterium.Single bacteria growing can be ignored.Medicine contrast and strain growth contrast are established in test simultaneously.The results are shown in Table 2.
Table 2 extracorporeal bacteria inhibitor test result
| Bacterial strain | Minimum inhibitory concentration (MIC) (mg/ml) |
| Shigella flexneri | 4.28 |
| Paratyphoid bacillus A | 11.42 |
| Bacillus paratyphosus B | 26.85 |
| Bacillus pyocyaneus | 4.93 |
| Escherichia coli | 46.76 |
| Bacillus enteritidis | 23.15 |
| Staphylococcus aureus | 7.08 |
As seen from Table 2, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, bacillus enteritidis.
Illustrate: human intestines and stomach belongs to hollow organ, in the ordinary course of things, utilize B ultrasonic can not well show coat of the stomach level, Ovum Gallus domesticus crusta in contrast agent of the present invention, Concha Meretricis Seu Cyclinae, in Os Draconis (calcined) and Cornu Cervi Degelatinatum, all contain the calcium carbonate of certain ingredients, with in gastric acid and after can produce carbon dioxide bubble, and need the 100-300ml that drinks water when Chinese medicine contrast agent of the present invention is taken or after taking, make to play obvious relieving gastric hyperacidity to alleviate stomachache effect after various Chinese Medicine and Clavicular, more clear on image, the strong reecho of point-like, see that coat of the stomach clear layer is visible, and after under these contrast agent clothes, the all mucosas of stomach are played a protective role, in ultrasound display screen, can see gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, it is obvious that greater gastric curvatures etc. are located video picture, each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas clear display, to all status of lymph node metastasis of stomach, also can clarify a diagnosis.Contrast agent of the present invention help shadow principle as follows: in the calcium carbonate in contrast agent He after gastric acid, produce carbon dioxide bubble, drink water and be " flakes " phenomenon of swimming after 100～300 milliliters, because the stickum in contrast agent is cliqued graph and resembled building up, be fused into rope piece or light on ulcer, cancerous protuberance mucomembranous surface, form obvious interface, and contrast agent can make the full difference of coat of the stomach mucosa aspect acoustic impedance that causes of gastral cavity, thereby show stomach form, position, gastral cavity size, wall of stomach thickness, emptying time and gastropathy place situation; Can show gastrointestinal dysfunction; The pathological changes that shows small intestinal, caecum, each position of colon.
The Chinese medicine contrast agent that B ultrasonic of the present invention is used is pure Chinese medicine contrast agent, has no side effect, and taking convenience; video picture is clear, strengthens the effect of gastric protective barrier, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache; diagnosis is accurate, through clinical the taking of 126 example, most gastrointestinal disease of clarifying a diagnosis.Within oral this product 5-12 minute, can get rid of stomach bubble, eliminate mucus and make coat of the stomach structure clear display, the clear stomach different lesions that shows, imaging results is good, and resolving power is high, image stabilization, with various ordinary ultrasonography b instruments, can carry out gastric B ultrasonic examination inspection, and there is invigorating the stomach and promoting digestion, de-swelling analgesic effect.According to the 126 routine clinical experiments of taking, good visualization ratio 95.2% (120 example), general visualization ratio 4.8% (6 example), can go out superficial gastritis, hypertrophic gastritis, prolapse of gastric mucosa, gastric cancer, pyloric part tumor, gastroptosis and duodenitis etc. by auxiliary diagnosis.
Model case:
Specific embodiment 1: Mrs Zhao, 41 years old, patient was because starting abdominal part distending pain, after cause again backache, come here medical, 3, the tablet of the oral embodiment of the present invention 1 of process, after 5 minutes, carry out ultrasound diagnosis, B ultrasonic diagnostic result: coat of the stomach mucosa echo is crude, is diagnosed as superficial gastritis.
Specific embodiment 2: Mr. Liu, 52 years old, because of epigastric discomfort, glutted, further obvious after meal, also have and feel sick simultaneously, belch, weak and constipation, health is become thin, come here medical, the powder 15g of the embodiment of the present invention of taking after mixing it with water 2, after 8 minutes, stomach ultrasound diagnosis is done in vertical position, Discover the patients stomach lower edge is lower than interiliac line 4.8CM, and diagnosis patient is gastroptosis.
Specific embodiment 3: Mr. Li, 36 years old, because of epigastrium pain, belch, acid regurgitation, nauseating, vomiting, examine, 3, the tablet of oral administration embodiment of the present invention l after 10 minutes, shows on ordinary ultrasonography b screen, duodenectasis distortion, interior is opaque dark area of fluid, and can visit and chyme echo luminous point, and the intestinal tube wall of limitation expansion is smooth, without obviously swelling, this patient that for this reason clarifies a diagnosis suffers from duodenitis.
Specific embodiment 4: Ms Zhang, 48 years old, central authorities and the always indistinct pain that takes on abdominal part, and scorching hot, numb and sharp sense, except substantially always pressing pain in upper central costal process source, other pain are indefinite as always migration, but substantially right costa sternales below is in the majority.The bimester of pain, have a surplus, before eight months, started to have the oral hemorrhage of unknown cause so far.After examining, the powder 15g of the embodiment of the present invention of taking after mixing it with water 2, after 10 minutes, stomach ultrasound diagnosis is done in vertical position, 5 layers of structure of coat of the stomach are differentiated unclear, in gastral cavity, there is low echo lump, rough, be cauliflower form, between stomach lower wall and pancreas, boundary is smudgy, there is low echo light group, near greater gastric curvature side, have multiple low echo nodules, be diagnosed as gastric cancer late period.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (4)
1. the Chinese medicine gastrointestinal contrast agent for B ultrasonic, it is characterized in that, the parts by weight of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent are: 30～40 parts of Ovum Gallus domesticus crustas, 20～30 parts of starfishes, 30～40 parts of Concha Meretricis Seu Cyclinaes, 20～30 parts of Fructus Elaeagni, 10～20 parts of Herba Agrimoniaes, 15～30 parts, Radix Glycyrrhizae, 10～20 parts of Os Draconis (calcined)s, 5～15 parts of Herba Hyperici perforatis, 5～15 parts of Herba Lythri Salicariae, 10～20 parts of Fructus Schisandrae Sphenantheraes, 10～20 parts of Radix Et Rhizoma Rhei, 5～15 parts of Radix rubi elliptici, 15～25 parts of Cornu Cervi Degelatinatums, 15～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 20～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 10～20 parts of Fructus Amomi subulati, 25～35 parts of Fructus clausenae lansii, 20～30 parts of Radix Et Rhizoma Nardostachyos, 5～15 parts of Pericarpium Arecae, 20～30 parts of 10～20 parts of Herba Pugionii Cornutis and Rhizoma Curcumae,
The dosage form of described Chinese medicine gastrointestinal contrast agent is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material of Chinese medicine gastrointestinal contrast agent, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 90%～95%, and reflux 2～4 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 5～8 times of described medicinal residues quality is 80%～85% again, and reflux 3～5 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.2～0.4 times of its quality, 0.02～0.06 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.
2. Chinese medicine gastrointestinal contrast agent as claimed in claim 1, it is characterized in that, the parts by weight of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent are: 35～40 parts of Ovum Gallus domesticus crustas, 25～30 parts of starfishes, 30～35 parts of Concha Meretricis Seu Cyclinaes, 20～25 parts of Fructus Elaeagni, 10～15 parts of Herba Agrimoniaes, 20～30 parts, Radix Glycyrrhizae, 15～20 parts of Os Draconis (calcined)s, 10～15 parts of Herba Hyperici perforatis, 5～10 parts of Herba Lythri Salicariae, 15～20 parts of Fructus Schisandrae Sphenantheraes, 10～15 parts of Radix Et Rhizoma Rhei, 8～12 parts of Radix rubi elliptici, 15～20 parts of Cornu Cervi Degelatinatums, 20～25 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 25～30 parts of Flos lupuli (Flos Humuli Lupuli)s, 15～20 parts of Fructus Amomi subulati, 25～30 parts of Fructus clausenae lansii, 20～25 parts of Radix Et Rhizoma Nardostachyos, 5～10 parts of Pericarpium Arecae, 20～25 parts of 10～15 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
3. Chinese medicine gastrointestinal contrast agent as claimed in claim 1, it is characterized in that, the parts by weight of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent are: 24 parts of 40 parts of Ovum Gallus domesticus crustas, 26 parts of starfishes, 33 parts of Concha Meretricis Seu Cyclinaes, 22 parts of Fructus Elaeagni, 13 parts of Herba Agrimoniaes, 28 parts, Radix Glycyrrhizae, 17 parts of Os Draconis (calcined)s, 13 parts of Herba Hyperici perforatis, 8 parts of Herba Lythri Salicariae, 18 parts of Fructus Schisandrae Sphenantheraes, 12 parts of Radix Et Rhizoma Rhei, 11 parts of Radix rubi elliptici, 15 parts of Cornu Cervi Degelatinatums, 24 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 29 parts of Flos lupuli (Flos Humuli Lupuli)s, 15 parts of Fructus Amomi subulati, 27 parts of Fructus clausenae lansii, 21 parts of Radix Et Rhizoma Nardostachyos, 8 parts of Pericarpium Arecae, 12 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
4. Chinese medicine gastrointestinal contrast agent as claimed in claim 1, it is characterized in that, the parts by weight of the various raw medicinal materials in described Chinese medicine gastrointestinal contrast agent are: 22 parts of 37 parts of Ovum Gallus domesticus crustas, 28 parts of starfishes, 35 parts of Concha Meretricis Seu Cyclinaes, 24 parts of Fructus Elaeagni, 11 parts of Herba Agrimoniaes, 24 parts, Radix Glycyrrhizae, 19 parts of Os Draconis (calcined)s, 12 parts of Herba Hyperici perforatis, 6 parts of Herba Lythri Salicariae, 15 parts of Fructus Schisandrae Sphenantheraes, 14 parts of Radix Et Rhizoma Rhei, 9 parts of Radix rubi elliptici, 17 parts of Cornu Cervi Degelatinatums, 21 parts of Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.), 26 parts of Flos lupuli (Flos Humuli Lupuli)s, 18 parts of Fructus Amomi subulati, 30 parts of Fructus clausenae lansii, 23 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Pericarpium Arecae, 13 parts of Herba Pugionii Cornutis and Rhizoma Curcumae.
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| CN104138605A (en) * | 2014-08-06 | 2014-11-12 | 王萌 | Quick photographic developer for stomach B-type ultrasonography |
| CN104800864A (en) * | 2015-04-24 | 2015-07-29 | 郑敏 | Stomach B-ultrasound imaging agent |
| CN105854033A (en) * | 2016-04-06 | 2016-08-17 | 王键 | Medicinal preparation for gastrointestinal contrast agent and preparation method thereof |
| CN105879065A (en) * | 2016-04-08 | 2016-08-24 | 李国玉 | Medicinal preparation for contrast media for gastrointestinal color Doppler ultrasound and preparation methods of medicinal preparation |
| CN105854036A (en) * | 2016-04-11 | 2016-08-17 | 王洪杰 | Ultrasound image diagnosis developing preparation and preparation method and application thereof |
| CN107812202A (en) * | 2017-11-20 | 2018-03-20 | 吉林大学 | A kind of pharmaceutical preparation of stomach and intestine color ultrasound assistant and preparation method thereof |
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