CN104307000A - Traditional Chinese medicine gastrointestinal developing agent for B ultrasound and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine gastrointestinal developing agent for B ultrasound and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: spiral shell, balanophyllia sp, phoenix tree seeds, sterculia nobilis, dahurian rose flower, birchleaf pear branchlet and leaf, fruits of lithocarpus polystachyus, auricledleaf swallowwort root, buerger raspberry root, herba agrimoniae, fimbriate calanthe pseudobulb, autumn cudweed herb, tylophora yunnanensis, forestry greenstar root, ampelopsis brevipedunculata, Tangut dragonhead herb with root and flatstiped corydalis herb. The traditional Chinese medicine gastrointestinal developing agent has the benefits that the traditional Chinese medicine gastrointestinal developing additive for B ultrasound is safe, painless and free of allergic reaction during use, is short in examination time, high in imaging rate, convenient to use and low in cost, and is an ideal novel developing agent, a strong basis is provided for the clinical diagnosis, and the preparation process is simple and practical.

Description

A kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof.

Background technology

Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three to act on greatly to material: one is mechanism, because ultrasonic energy is huge, often makes material particle do altofrequency mechanical vibration, thus produce smash, condense, agitation effects.Two is warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature raise phenomenon.Three is cavitations, when ul-trasonic irradiation is on liquid, become sparse in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure great variety, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.This cavity time of staying is not long, collapses again under huge acoustic pressure effect, and formed due to cavity and disappear, producing a large amount of bubble will affect ultrasonic diagnosis effect, so, eliminate the Main Function that bubble is ultrasonic contrast agent.

At present, for B ultrasonic gastrointestinal contrast agent, prior art describes the contrast agent be mixed with by the 100 order fine powders of Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, to gastrointestinal disease, there is convergence, antacid effect, but weak point is patient take contrast agent after to produce strong echo luminous point not enough, reflecting effect is not good, and the display of coat of the stomach level is unintelligible; After patient takes this contrast agent, gastric acid strong reaction, has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not applies this contrast agent to gastrorrhagia patient.

Another kind of fast ultrasonic image-developing liquor preparation method is that make imaging liquid, excellent video picture rate reaches 87% through decocting, distilling, concentrate after bitter bucket, MIXIANG, abdomen floss, Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, sucrose being mixed in proportion.Used bitter bucket in this prescription, taste is extremely bitter, thus improves mouthfeel with sucrose, and sucrose enters in gastric juice and easily produces bubble, thus has impact to imaging results, and in addition, this invention product is without therapeutical effect.

Summary of the invention

Technical problem to be solved by this invention is, utilize the theory of Chinese medical science that China is traditional, provide a kind of novel use safety, avirulence, have no side effect, the review time is short, video picture rate is high, Chinese medicine gastrointestinal contrast agent for B ultrasonic easy to use and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic, described Chinese medicine comprises following raw medicinal material: Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae, Ramulus et folium pyri betulaefoliae, multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 30 ~ 40 parts, snail shell, Hai Baishi 20 ~ 30 parts, Semen Firmianae 30 ~ 40 parts, Semen Sterculiae Nobilis 10 ~ 20 parts, Flos Rosae Davuricae 10 ~ 20 parts, Ramulus et folium pyri betulaefoliae 15 ~ 25 parts, multiple-ear rock Ke fruit 10 ~ 20 parts, Radix Cynanchi Otophylli 5 ~ 15 parts, Radix rubi buergeri 15 ~ 25 parts, Herba Agrimoniae 5 ~ 15 parts, pseudobulbus Calanthes fimbriatae 5 ~ 15 parts, 15 ~ 25 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 15 parts, Polyalthia nemoralis A. D C. 20 ~ 30 parts, ampelopsis heterophylla 10 ~ 20 parts, Herba Dracocephali tangutici 5 ~ 15 parts and flatstiped corydalis herb 5 ~ 15 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: white 30 ~ 35 parts, snail shell, Hai Baishi 20 ~ 25 parts, Semen Firmianae 30 ~ 35 parts, Semen Sterculiae Nobilis 10 ~ 15 parts, Flos Rosae Davuricae 10 ~ 15 parts, Ramulus et folium pyri betulaefoliae 15 ~ 20 parts, multiple-ear rock Ke fruit 10 ~ 15 parts, Radix Cynanchi Otophylli 5 ~ 10 parts, Radix rubi buergeri 15 ~ 20 parts, Herba Agrimoniae 5 ~ 10 parts, pseudobulbus Calanthes fimbriatae 5 ~ 10 parts, 15 ~ 20 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 10 parts, Polyalthia nemoralis A. D C. 20 ~ 25 parts, ampelopsis heterophylla 10 ~ 15 parts, Herba Dracocephali tangutici 5 ~ 10 parts and flatstiped corydalis herb 5 ~ 10 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: white 32 parts, snail shell, white 24 parts, the stone in sea, Semen Firmianae 34 parts, Semen Sterculiae Nobilis 11 parts, Flos Rosae Davuricae 14 parts, Ramulus et folium pyri betulaefoliae 18 parts, multiple-ear rock Ke fruit 12 parts, Radix Cynanchi Otophylli 7 parts, Radix rubi buergeri 18 parts, Herba Agrimoniae 6 parts, pseudobulbus Calanthes fimbriatae 7 parts, 16 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 8 parts, Polyalthia nemoralis A. D C. 21 parts, ampelopsis heterophylla 12 parts, Herba Dracocephali tangutici 7 parts and flatstiped corydalis herb 6 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: white 34 parts, snail shell, white 21 parts, the stone in sea, Semen Firmianae 32 parts, Semen Sterculiae Nobilis 14 parts, Flos Rosae Davuricae 12 parts, Ramulus et folium pyri betulaefoliae 16 parts, multiple-ear rock Ke fruit 14 parts, Radix Cynanchi Otophylli 8 parts, Radix rubi buergeri 16 parts, Herba Agrimoniae 7 parts, pseudobulbus Calanthes fimbriatae 8 parts, 18 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 6 parts, Polyalthia nemoralis A. D C. 23 parts, ampelopsis heterophylla 14 parts, Herba Dracocephali tangutici 6 parts and flatstiped corydalis herb 8 parts.

Present invention also offers a kind of preparation method of the above-mentioned Chinese medicine gastrointestinal contrast agent for B ultrasonic, the dosage form of described Chinese medicine contrast agent is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.00 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 ~ 0.5 times and 0.2 ~ 0.4 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Present invention also offers a kind of preparation method of the above-mentioned Chinese medicine gastrointestinal contrast agent for B ultrasonic, when the dosage form of described Chinese medicine contrast agent is syrup, its preparation method comprises the following steps:

The first step, by multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb mix in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae and Ramulus et folium pyri betulaefoliae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 2 ~ 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 65%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.02 ~ 0.06%.

Beneficial effect of the present invention: the Chinese medicine contrast agent use safety that B ultrasonic of the present invention uses, no pain, without anaphylaxis, review time is short, video picture rate is high, easy to use, cost is low, for clinical diagnosis provides strong foundation, be ideal novel contrast agent, and preparation technology is simple, practical.

Detailed description of the invention

The invention provides a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic, described Chinese medicine comprises following raw medicinal material: Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae, Ramulus et folium pyri betulaefoliae, multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb.

The pharmacology of various raw medicinal material is as follows:

Carapax Bellamyae quadratae: sweet is light, flat.Reduce phlegm, eliminating stagnation, pain relieving, sore.Control phlegm heat cough, regurgitation, stomachache, acid regurgitation, scrofula, ulcer, burn.

Hai Baishi: sweet in the mouth, property is put down.Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.Main dysentery, tracheitis, scrofula.

Semen Firmianae: sweet in the mouth, property is put down.GUIXIN, lung, stomach warp.Pleasant stomach function regulating, strengthening the spleen to promote digestion, hemostasis.For gastralgia, diarrhoea of getting ill from overeating, hernia, early whitening of beard and hair, oral aphthae in children.

Semen Sterculiae Nobilis: sweet is flat.Return stomach, large intestine, small intestine meridian.Stomach function regulating helps digestion, removing toxic substances parasite killing.Main regurgitation of food from the stomach tells food, abdominal pain due to worm stagnation, colic, the rotten head infections of children's.

Flos Rosae Davuricae: acid, sweet, flat.Return liver, spleen channel.Regulating qi-flowing for harmonizing stomach, cough-relieving.Main menoxenia, dysmenorrhea, metrorrhagia, spits blood, intercostal neuralgia, pulmonary tuberculosis cough.

Ramulus et folium pyri betulaefoliae: acid is sweet puckery, cold.Return large intestine channel.Dispersing the stagnated liver-QI for regulating the stomach, emergency antidiarrheal.Food is told in main regurgitation, and cholera is vomited and diarrhoea, convulsion stomachache.

Multiple-ear rock Ke fruit: sweet, puckery, property is put down.Regulating the stomach and sending down the abnormal ascending QI.Main singultus, dysphagic.

Radix Cynanchi Otophylli: sweet in the mouth, pungent, warm in nature.Return liver, spleen, kidney channel.Wind-damp dispelling, Yishen Jianpi stomach function regulating, anthelmintic.Main air pain of dampness syndrome, lumbago due to renal deficiency, lumbar muscle strain, falling winks frustrates, food stagnation, abdominal distention, infantile malnutrition, Serpentis, lyssodexis.

Radix rubi buergeri: acid is flat.Return liver, kidney channel.Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Treat for stomachache acid regurgitation, icterohepatitis, vomits and diarrhoea, leucorrhea, hemorrhoid." practical Chinese herbal medicine ": convergence, removing toxic substances, pain relieving.Treat for stomachache, hyperchlorhydria, seminal emission, headache.

Herba Agrimoniae: bitter, pungent is flat.Return lung, liver, spleen channel.Hemostasis, stomach invigorating.Control hemoptysis, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, too fat to move, traumatic injury, wound hemorrhage.

Pseudobulbus Calanthes fimbriatae: pungent is bitter, cool.Heat-clearing and toxic substances removing, scattered silt pain relieving.For gastric ulcer, acute gastric dilatation, chronic hepatitis, lumbago, stomachache, lymphoid tuberculosis, chronic pharyngitis, toothache, sand Stranguria, amenorrhea, arthralgia, venom, traumatic injury.

Herba Gnaphalii Hypoleuci: sweet is bitter, flat.Return lung, Liver Channel.Dispel the wind, dispersing lung-QI and dissipating phlegm, separates noxious dampness.Control Common Cold, cough with copious phlegm, asthma, eczema, ulcer of the lower limb.Soviet Union doctor " Chinese herbal medicine handbook ": moistening the lung and resolving phlegm, relieving cough and asthma, blood pressure lowering.Cure cold cough, chronic bronchitis, asthma, hypertension, gastric ulcer; And control dysmenorrhea, traumatic injury, skin ulceration, eczema, bones and muscles pain due to rheumatism.

Radix Tylophorae Yunnanensis: bitter, puckery, temperature.Relaxing muscles and tendons and activating QI and blood in the collateral, menstruction regulating and pain relieving, preventing the attack (or recurrence) of malaria.For hepatitis, gastric ulcer, malaria, rheumatic arthritis, traumatic injury; Worm venom is controlled in external.

Polyalthia nemoralis A. D C.: sweet is flat.Return spleen, stomach, kidney channel.Invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence.Control chronic gastritis, taste lose, inappetence, myasthenia of limbs, seminal emission.

Ampelopsis heterophylla: pungent is bitter, puckery, cool.Expelling wind and removing dampness, removing toxic substances, sore.Main air wet arthritis, gastric ulcer, traumatic injury, scalds, skin infection, erysipelas.

Herba Dracocephali tangutici: acrid in the mouth is bitter, cold in nature.Clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing.Main icterohepatitis, gastritis, gastric ulcer, tracheitis.

Flatstiped corydalis herb: bitter, cold.Heat-clearing and toxic substances removing, pain relieving.Main flow sense, epidemic febrile disease is generated heat, and gastritis, Peptic Ulcers, dysentery, sciatica, furuncle swells and ache.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 30 ~ 40 parts, snail shell, Hai Baishi 20 ~ 30 parts, Semen Firmianae 30 ~ 40 parts, Semen Sterculiae Nobilis 10 ~ 20 parts, Flos Rosae Davuricae 10 ~ 20 parts, Ramulus et folium pyri betulaefoliae 15 ~ 25 parts, multiple-ear rock Ke fruit 10 ~ 20 parts, Radix Cynanchi Otophylli 5 ~ 15 parts, Radix rubi buergeri 15 ~ 25 parts, Herba Agrimoniae 5 ~ 15 parts, pseudobulbus Calanthes fimbriatae 5 ~ 15 parts, 15 ~ 25 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 15 parts, Polyalthia nemoralis A. D C. 20 ~ 30 parts, ampelopsis heterophylla 10 ~ 20 parts, Herba Dracocephali tangutici 5 ~ 15 parts and flatstiped corydalis herb 5 ~ 15 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: white 30 ~ 35 parts, snail shell, Hai Baishi 20 ~ 25 parts, Semen Firmianae 30 ~ 35 parts, Semen Sterculiae Nobilis 10 ~ 15 parts, Flos Rosae Davuricae 10 ~ 15 parts, Ramulus et folium pyri betulaefoliae 15 ~ 20 parts, multiple-ear rock Ke fruit 10 ~ 15 parts, Radix Cynanchi Otophylli 5 ~ 10 parts, Radix rubi buergeri 15 ~ 20 parts, Herba Agrimoniae 5 ~ 10 parts, pseudobulbus Calanthes fimbriatae 5 ~ 10 parts, 15 ~ 20 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 10 parts, Polyalthia nemoralis A. D C. 20 ~ 25 parts, ampelopsis heterophylla 10 ~ 15 parts, Herba Dracocephali tangutici 5 ~ 10 parts and flatstiped corydalis herb 5 ~ 10 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: white 32 parts, snail shell, white 24 parts, the stone in sea, Semen Firmianae 34 parts, Semen Sterculiae Nobilis 11 parts, Flos Rosae Davuricae 14 parts, Ramulus et folium pyri betulaefoliae 18 parts, multiple-ear rock Ke fruit 12 parts, Radix Cynanchi Otophylli 7 parts, Radix rubi buergeri 18 parts, Herba Agrimoniae 6 parts, pseudobulbus Calanthes fimbriatae 7 parts, 16 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 8 parts, Polyalthia nemoralis A. D C. 21 parts, ampelopsis heterophylla 12 parts, Herba Dracocephali tangutici 7 parts and flatstiped corydalis herb 6 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: white 34 parts, snail shell, white 21 parts, the stone in sea, Semen Firmianae 32 parts, Semen Sterculiae Nobilis 14 parts, Flos Rosae Davuricae 12 parts, Ramulus et folium pyri betulaefoliae 16 parts, multiple-ear rock Ke fruit 14 parts, Radix Cynanchi Otophylli 8 parts, Radix rubi buergeri 16 parts, Herba Agrimoniae 7 parts, pseudobulbus Calanthes fimbriatae 8 parts, 18 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 6 parts, Polyalthia nemoralis A. D C. 23 parts, ampelopsis heterophylla 14 parts, Herba Dracocephali tangutici 6 parts and flatstiped corydalis herb 8 parts.

The present invention further provides again a kind of preparation method of the above-mentioned Chinese medicine gastrointestinal contrast agent for B ultrasonic, and the dosage form of described Chinese medicine contrast agent is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.00 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 ~ 0.5 times and 0.2 ~ 0.4 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The present invention further provides a kind of preparation method of the above-mentioned Chinese medicine gastrointestinal contrast agent for B ultrasonic again, and when the dosage form of described Chinese medicine contrast agent is syrup, its preparation method comprises the following steps:

The first step, by multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb mix in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae and Ramulus et folium pyri betulaefoliae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 2 ~ 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 65%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.02 ~ 0.06%.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule

Get white snail shell 320g, sea white stone 240g, Semen Firmianae 340g, Semen Sterculiae Nobilis 110g, Flos Rosae Davuricae 140g, Ramulus et folium pyri betulaefoliae 180g, multiple-ear rock Ke fruit 120g, Radix Cynanchi Otophylli 70g, Radix rubi buergeri 180g, Herba Agrimoniae 60g, pseudobulbus Calanthes fimbriatae 70g, Herba Gnaphalii Hypoleuci 160g, Radix Tylophorae Yunnanensis 80g, Polyalthia nemoralis A. D C. 210g, ampelopsis heterophylla 120g, Herba Dracocephali tangutici 70g and flatstiped corydalis herb 60g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 80%, be heated to boiling reflux 2 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.5 times and 0.4 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2: syrup

Get white snail shell 340g, sea white stone 210g, Semen Firmianae 320g, Semen Sterculiae Nobilis 140g, Flos Rosae Davuricae 120g, Ramulus et folium pyri betulaefoliae 160g, multiple-ear rock Ke fruit 140g, Radix Cynanchi Otophylli 80g, Radix rubi buergeri 160g, Herba Agrimoniae 70g, pseudobulbus Calanthes fimbriatae 80g, Herba Gnaphalii Hypoleuci 180g, Radix Tylophorae Yunnanensis 60g, Polyalthia nemoralis A. D C. 230g, ampelopsis heterophylla 140g, Herba Dracocephali tangutici 60g and flatstiped corydalis herb 80g.

Its preparation method comprises the following steps:

The first step, by multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb mix in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 95%, heating and refluxing extraction 4 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder,

Second step, Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae and Ramulus et folium pyri betulaefoliae being mixed in described ratio, be ground into powder, is that the ethanol of 95% is as solvent with determining alcohol, flood 72 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.27, dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;

3rd step, mixes remaining raw medicinal material in described ratio, add relative to mixture 4 times amount determining alcohol be 80% alcohol reflux 2 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.22, in 65 DEG C of reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 45%, potassium sorbate 0.1% and ethyl hydroxybenzoate 0.02%.

Acute toxicity test: be dissolved in distilled water with granule prepared by the embodiment of the present invention 1, gives 4 groups of white mice feeding dispensings or wiping respectively with 80 of clinical consumption per day times, 120 times, 150 times and 230 times, observes 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test: the granule embodiment of the present invention 1 prepared is dissolved in water by 16.47,32.88 and 66.23g crude drug/kg, continuous uses 16 weeks are distinguished to 3 groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to 3 groups of test mices all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Pharmacological experiment illustrates:

Pharmacodynamic experiment

One, the granule of Chinese medicine contrast agent of the present invention impact that small intestine movement of mice is moved

1 test material

1.1 experimental animals: by medical college biological study room, Shandong ICR mice 100, male and female half and half, body weight 17 ~ 22g.

1.2 trial drugs:

1.2.1 the granule of Chinese medicine contrast agent of the present invention.Chinese medicine contrast agent particle agent distilled water of the present invention is dissolved into 0.467,0.233, the medicinal liquid of 0.117g crude drug/ml is stand-by.

1.2.2 atropine sulfate injection (Xinxiang City, Henan Province Chang Le pharmaceutical factory, H41020226), uses front normal saline dilution to become 0.01mg/ml solution.

1.2.3 active carbon; Arabic gum (making containing 10% Radix Acaciae senegalis, the charcoal end distilled water suspension of 5% active carbon).

1.3 testing equipments: T-500 electronic balance (Changshu Shuan Jie test instrunment factory, numbering: 256), PL203 precision electronic balance.

2 test methods

Select 17 ~ 22g body weight mice, be divided into 5 groups by the method for body weight random stratified, be i.e. blank group, positive drug (atropine) group, the high, medium and low dosage group of Chinese medicine granules of the present invention.Often organize 20, male and female half and half.Blank group and atropine group gavage distilled water 30ml/kg, the other gavage of high, medium and low dosage component Chinese medicine granules medicinal liquid of the present invention 14,7,3.5g crude drug/kg, 1 time/d.Gavage is after 7 days, can't help water 18h in the experiment the previous day of fasting at dusk, and after the 8th day last administration 1h (atropine diluent 0.1mg/kg5min), each group gavage charcoal end suspension 0.2ml/ only.Animal is put to death after 20min; open abdominal cavity and be separated mesentery; see that coat of the stomach clear layer is visible, and this contrast agent takes down, stomach week mucosa is played a protective role; ultrasound display screen can be seen place's video pictures such as gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature obvious; each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display clear, clip front end is to pylorus; rear end, to the intestinal tube of ileocecus, is placed on pallet.Gently small intestinal is put into straight line, measures Length of intestine as " total small intestinal length ".From pylorus to the distance in prepared Chinese ink forward position as " distance that prepared Chinese ink advances at enteral ".Formulae discovery ink progradation: ink progradation=(prepared Chinese ink is in enteral advance distance/small intestinal total length) × 100%.

3 result of the tests

Compare with matched group, positive drug atropine group charcoal end delaunay triangle rate obviously reduces (P<0.05), and the gastric peristalsis of Chinese medicine granules of the present invention is obviously hyperfunction, compares with model control group, can obviously promote gastrointestinal motility function.In table 1.

The granule of table 1 Chinese medicine of the present invention contrast agent is on the impact of the hyperfunction mouse small intestine motion of intestinal propulsion

Group	Number of cases	Delaunay triangle rate %
			Normal group	20	40.75±3.64
Positive drug atropine group	20	57.42±9.57***
			Granule 3.5g crude drug/kg of the present invention	20	69.87±14.55**
Granule 7g crude drug/kg of the present invention	20	76.62±12.36
			Granule 14g crude drug/kg of the present invention	20	89.33±9.81

Note: compare with Normal group: P<0.05, compares with model control group: * * P<0.01, * * * P<0.001.

Conclusion (of pressure testing): the granule 3.5g/kg of Chinese medicine contrast agent of the present invention has obvious inhibitory action to the motion of gastrointestinal motility hyperfunctioning mouse small intestine, increases, show the trend promoting bowel movement effect with dosage.This test is from the Granules in Treating gastropathy that have studied Chinese medicine contrast agent of the present invention in body and the impact of in vitro function of intestinal canal, stopping leak, antibacterial, the anti-immunity of antiinflammatory etc., the Pharmacological Mechanism of enteritis, dysentery, gastrointestinal motility can be promoted, digestion, absorption, and have certain bacteriostasis, and show the anti-immunization of stronger antiinflammatory.

Two, In vitro Bactericidal Experiments

Double broth dilution method is adopted to measure the minimum inhibitory concentration (MIC) of the present invention to common pathogen.Be inoculated in by tested bacterium in MH broth bouillon, cultivate after 18 hours for 35 DEG C, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 10 8CFU/ml.With physiological saline solution dilution 1: 10 (bacteria containing amount about 10 7CFU/ml).Get the medicinal liquid 2ml diluted for series concentration respectively to add and perform in the flat board of labelling, then the MH agar culture medium 18ml being chilled to about 50 DEG C after getting thawing be added to dull and stereotyped in (medicine: agar=1: 9) makes medicine and culture medium fully mix.Medicine ultimate density is respectively 200,100,50 ... 0.78,0.39mg/ml.Be inoculated on pastille flat board by the bacteria suspension inoculating loop prepared, cultivate 18 hours observed results in 35 DEG C, the lowest concentration of drug that colony growth is totally constrained is that this medicine is to the MIC detecting bacterium.Single bacteria growing can be ignored.Drug control and strain growth contrast are established in test simultaneously.The results are shown in Table 2.

Table 2 extracorporeal bacteria inhibitor test result

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Shigella flexneri	4.884
Paratyphoid bacillus A	11.48
		Bacillus paratyphosus B	26.49
Bacillus pyocyaneus	6.35
		Escherichia coli	49.18
Bacillus enteritidis	22.86
		Staphylococcus aureus	7.14

As seen from Table 2, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, bacillus enteritidis.

Illustrate: human intestines and stomach belongs to hollow organ, in the ordinary course of things, B ultrasonic is utilized can not well to show coat of the stomach level, calcium carbonate all containing certain ingredients in Carapax Bellamyae quadratae in contrast agent of the present invention and Hai Baishi, with in gastric acid and after can produce carbon dioxide bubble, and Chinese medicine contrast agent of the present invention is when taking or need the 100-300ml that drinks water after taking, obvious relieving gastric hyperacidity to alleviate stomachache effect is played after making various Chinese Medicine and Clavicular, more clear on image, the strong reecho of point-like, see that coat of the stomach clear layer is visible, and this contrast agent takes down, stomach week mucosa is played a protective role, ultrasound display screen can see gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, place's video pictures such as greater gastric curvature are obvious, each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display is clear, also can clarify a diagnosis to stomach week status of lymph node metastasis.Contrast agent of the present invention help shadow principle as follows: produce carbon dioxide bubble in the calcium carbonate in contrast agent He after gastric acid, drink water 100 ~ 300 milliliters and to swim phenomenon in " flakes " afterwards, because the stickum in contrast agent is cliqued graph resemble ulcer, cancerous protuberance mucomembranous surface being built up, be fused into rope block or light, form obvious interface, because contrast agent can make gastral cavity fill the difference causing gastric wall mucus in acoustic impedance, thus show stomach form, position, gastral cavity size, wall of stomach thickness, emptying time and gastropathy place situation; Gastrointestinal dysfunction can be shown; The pathological changes at display small intestinal, caecum, each position of colon.

The Chinese medicine contrast agent that B ultrasonic of the present invention uses is pure Chinese medicine contrast agent; no side effects; taking convenience; video picture is clear, strengthens the effect of gastric protective barrier, and diagnosis accurately; clinically take (wherein through 198 examples; 106 examples use the granule of the embodiment of the present invention 1, and 92 examples use the syrup of the embodiment of the present invention 2), various gastrointestinal disease of clarifying a diagnosis.Within oral this product 5-13 minute, stomach bubble can be got rid of, eliminate mucus and make the display of coat of the stomach structure clear, clear display stomach different lesions, imaging results is good, and resolving power is high, image stabilization, can gastric B ultrasonic examination inspection be carried out with various ordinary ultrasonography b instrument, and there is invigorating the stomach and promoting digestion, de-swelling analgesic effect.According to clinical diagnostic tests, excellent visualization ratio 92.68%, general visualization ratio 3.75%, can go out superficial gastritis, hypertrophic gastritis, prolapse of gastric mucosa, gastric cancer, pyloric part tumor, gastroptosis and duodenitis etc. by auxiliary diagnosis.

Concrete case:

Zheng, man, 40 years old, often has epigastrium pain over nearly 3 years, is calcination sample pain, without diffusing, more than occurring before the meal, can alleviates after feed, occasionally having pain at night, having acid regurgitation, belch, non-system diagnosis and treatment.Melena was clapped before 5 days, in discontinuity, shapeless, there is Nausea and vomiting without obvious inducement before 2 days, without dizzy cardiopalmus, on B ultrasonic diagnostic screen, show pyloric cap through the contrast agent of the oral embodiment of the present invention 1 and occur ulcer, be diagnosed as gastric ulcer.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. the Chinese medicine gastrointestinal contrast agent for B ultrasonic, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae, Ramulus et folium pyri betulaefoliae, multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb.

2. as claimed in claim 1 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 30 ~ 40 parts, snail shell, Hai Baishi 20 ~ 30 parts, Semen Firmianae 30 ~ 40 parts, Semen Sterculiae Nobilis 10 ~ 20 parts, Flos Rosae Davuricae 10 ~ 20 parts, Ramulus et folium pyri betulaefoliae 15 ~ 25 parts, multiple-ear rock Ke fruit 10 ~ 20 parts, Radix Cynanchi Otophylli 5 ~ 15 parts, Radix rubi buergeri 15 ~ 25 parts, Herba Agrimoniae 5 ~ 15 parts, pseudobulbus Calanthes fimbriatae 5 ~ 15 parts, 15 ~ 25 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 15 parts, Polyalthia nemoralis A. D C. 20 ~ 30 parts, ampelopsis heterophylla 10 ~ 20 parts, Herba Dracocephali tangutici 5 ~ 15 parts and flatstiped corydalis herb 5 ~ 15 parts.

3. as claimed in claim 1 or 2 for the Chinese medicine gastrointestinal contrast agent of B ultrasonic, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 30 ~ 35 parts, snail shell, Hai Baishi 20 ~ 25 parts, Semen Firmianae 30 ~ 35 parts, Semen Sterculiae Nobilis 10 ~ 15 parts, Flos Rosae Davuricae 10 ~ 15 parts, Ramulus et folium pyri betulaefoliae 15 ~ 20 parts, multiple-ear rock Ke fruit 10 ~ 15 parts, Radix Cynanchi Otophylli 5 ~ 10 parts, Radix rubi buergeri 15 ~ 20 parts, Herba Agrimoniae 5 ~ 10 parts, pseudobulbus Calanthes fimbriatae 5 ~ 10 parts, 15 ~ 20 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 5 ~ 10 parts, Polyalthia nemoralis A. D C. 20 ~ 25 parts, ampelopsis heterophylla 10 ~ 15 parts, Herba Dracocephali tangutici 5 ~ 10 parts and flatstiped corydalis herb 5 ~ 10 parts.

4. the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 32 parts, snail shell, white 24 parts, the stone in sea, Semen Firmianae 34 parts, Semen Sterculiae Nobilis 11 parts, Flos Rosae Davuricae 14 parts, Ramulus et folium pyri betulaefoliae 18 parts, multiple-ear rock Ke fruit 12 parts, Radix Cynanchi Otophylli 7 parts, Radix rubi buergeri 18 parts, Herba Agrimoniae 6 parts, pseudobulbus Calanthes fimbriatae 7 parts, 16 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 8 parts, Polyalthia nemoralis A. D C. 21 parts, ampelopsis heterophylla 12 parts, Herba Dracocephali tangutici 7 parts and flatstiped corydalis herb 6 parts.

5. the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in Claims 1-4, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: white 34 parts, snail shell, white 21 parts, the stone in sea, Semen Firmianae 32 parts, Semen Sterculiae Nobilis 14 parts, Flos Rosae Davuricae 12 parts, Ramulus et folium pyri betulaefoliae 16 parts, multiple-ear rock Ke fruit 14 parts, Radix Cynanchi Otophylli 8 parts, Radix rubi buergeri 16 parts, Herba Agrimoniae 7 parts, pseudobulbus Calanthes fimbriatae 8 parts, 18 parts, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis 6 parts, Polyalthia nemoralis A. D C. 23 parts, ampelopsis heterophylla 14 parts, Herba Dracocephali tangutici 6 parts and flatstiped corydalis herb 8 parts.

6. the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine contrast agent is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.00 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 ~ 0.5 times and 0.2 ~ 0.4 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

7. the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine contrast agent is syrup, its preparation method comprises the following steps:

The first step, by multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb mix in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae and Ramulus et folium pyri betulaefoliae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 2 ~ 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 65%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.02 ~ 0.06%.

8. the preparation method of the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine contrast agent is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.00 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 ~ 0.5 times and 0.2 ~ 0.4 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. the preparation method of the Chinese medicine gastrointestinal contrast agent for B ultrasonic as described in Claims 1-4, it is characterized in that, when the dosage form of described Chinese medicine contrast agent is syrup, its preparation method comprises the following steps:

The first step, by multiple-ear rock Ke fruit, Radix Cynanchi Otophylli, Radix rubi buergeri, Herba Agrimoniae, pseudobulbus Calanthes fimbriatae, Herba Gnaphalii Hypoleuci, Radix Tylophorae Yunnanensis, Polyalthia nemoralis A. D C., ampelopsis heterophylla, Herba Dracocephali tangutici and flatstiped corydalis herb mix in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Carapax Bellamyae quadratae, Hai Baishi, Semen Firmianae, Semen Sterculiae Nobilis, Flos Rosae Davuricae and Ramulus et folium pyri betulaefoliae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 2 ~ 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 65%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.02 ~ 0.06%.