CN108210477A - Delay flexible glue cyst fluid, soft capsule and the forefront capsule and its preparation method of rubber aging - Google Patents
Delay flexible glue cyst fluid, soft capsule and the forefront capsule and its preparation method of rubber aging Download PDFInfo
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- CN108210477A CN108210477A CN201711314242.8A CN201711314242A CN108210477A CN 108210477 A CN108210477 A CN 108210477A CN 201711314242 A CN201711314242 A CN 201711314242A CN 108210477 A CN108210477 A CN 108210477A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
Abstract
The present invention relates to soft capsule technical fields, and in particular to a kind of flexible glue cyst fluid for delaying rubber aging, soft capsule and forefront capsule and its preparation method.Flexible glue cyst fluid includes gelatin, glycerine, sorbierite, pigment, opacifier, preservative and water, the rubber aging that soft capsule is made delays, the indexs such as capsule and pill disintegration time limited and dissolution meet the requirements in Storage period, improve stability and the shelf-life of Chinese medicinal soft capsule, and disintegration stability is 24 months.It the benefits of there is clearing away heat and promoting diuresis, promoting blood circulation and removing blood stasis, dredging collateral menstruation regulating the present invention also provides a kind of forefront capsule of the cooperation with soft capsule, is tested through modern pharmacodynamic study, available for treating various prostatitis, is particularly suitable for chronic prostatitis.
Description
Technical field
The present invention relates to soft capsule technical fields, and in particular to a kind of flexible glue cyst fluid for delaying rubber aging, soft capsule and
Forefront capsule and its preparation method.
Background technology
The formulation characteristic of soft capsule determines that the built-in drug of capsule shells is isolated from the outside world, appearance character, disintegration with it is molten
Go out, the quality index such as stability, none is not influenced by capsule casing material；Meanwhile the drug composition in capsule also can shadow with property
Ring the stability of softgel shell.Traditional soft capsule rubber formula is by groups such as gelatin, glycerine, water, titanium dioxide, ethyl hydroxy benzoate and pigments
Into rubber is easily oxidized to aldehydes during storage, forms thin film, capsule is made to be difficult to dissolve out.
Simultaneously soft capsule have plasticity and elasticity, can it is moisture-proof, anti-oxidation, be protected from light, and the stability of drug can be improved, outside
Fineness is seen, is easily received by patient, wherein treating antibacterial anti-inflammatory of the prostatitic drug with a variety of volatility or easily oxidizable
Ingredient is particularly suitable for that soft capsule is made.But the elution profiles of existing soft capsule can not meet prostate very well
The demand of scorching drug.
Invention content
In order to overcome shortcoming and defect in the prior art, the purpose of the present invention is to provide one kind to delay rubber old
The flexible glue cyst fluid of change and corresponding soft capsule, another object of the present invention is to provide to match to merge with the soft capsule to improve prostate
The forefront capsule and preparation method of the effect of scorching.
The purpose of the present invention is achieved through the following technical solutions：
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
The present invention is used as moisturizer by adding the sorbierite of proper ratio, and the plasticizer of glycerine is coordinated to act on, makes flexible glue
The rubber aging of capsule delays, and the indexs such as capsule and pill disintegration time limited and dissolution meet the requirements in Storage period, improve Chinese medicinal soft capsule
Stability and shelf-life.
Preferably, the capsule liquid is made of the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide.Edible titanium dioxide is commonly called as antholeucin, is the letter of food-level titanium dioxide
Claim.It is compared with the anatase titanium dioxide of high score non-packet film process, also referred to as food-grade titanium dioxide or pharmaceutical grade titanium white
Powder is used as colorant and food brightening agent, nontoxic, tasteless, white powder, is sometimes disperseed for convenience, is also made
It is liquid, it is widely used in pharmacy, in foods and cosmetics industry.But Chinese medicinal soft capsule adds titanium dioxide, if usage amount mistake
Greatly, then the plasticity of capsule skin can be influenced, is easy to cause capsules break, dosage is too small, influences its shaded effect, causes content
Object is apt to deteriorate, therefore certain Chinese medicinal soft capsules can add pigment to enhance its shaded effect.Titanium dioxide can not only be reduced
Additive amount, and Chinese medicinal soft capsule is prepared into various different colours, is convenient for people to distinguish and eat, in addition, Chinese medicine flexible glue
The content of capsule is mostly the powder of black, and patient, especially children see that its content can generate it in larger resistance heart
Reason, be unwilling to eat, then can influence the treatment of the state of an illness, therefore cover its content with more chromatic colour, can greatly improve disease
The acceptance of people, greatly plays drug effect.
Wherein, the preservative is ethyl hydroxy benzoate.Ethyl hydroxy benzoate entitled 4-HBA ethyl ester entirely is white crystalline
Powder, readily soluble in methanol, ethyl alcohol or ether, slightly molten in chloroform, the slightly soluble in glycerine are almost insoluble in water.This
Invention selects glycerine that can effectively enhance the antisepsis of ethyl hydroxy benzoate, can reduce the additive amount of ethyl hydroxy benzoate as plasticizer,
Reduce the harmful effect to human body.
The present invention also provides a kind of preparation method for the flexible glue cyst fluid for delaying rubber aging as described above, feature exists
In：Include the following steps：
(1) opacifier and a part of water is taken to be ground dispersion, obtains shading agent dispersing liquid；
(2) pigment is taken to be dissolved in another part water, obtains pigment solution；
(3) glycerine, sorbierite and remaining water are mixed, and be heated to 40-80 DEG C, sequentially add opacifier dispersion
Liquid, pigment solution, gelatin and preservative, stirring and dissolving, vacuumizing and exhausting bubble is to get to the capsule liquid.
Wherein, the total accounting 10wt%-20wt% of a part of water of the step (1), a part of water of step (2) are complete with energy
It is advisable into dissolving pigment.
The present invention also provides a kind of forefront capsule, including by the flexible glue cyst fluid of rubber aging is delayed to be made as described above
Soft capsule and the Chinese medicine composition that is loaded into soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the raw material of following parts by weight is further included：
Preferably, it is made of the raw material of following parts by weight：
The soft capsule obtained and the Chinese medicine composition being loaded into soft capsule, the Chinese medicine composition include following parts by weight
Several raw materials：
Preferably, it is made of the raw material of following parts by weight：
The present invention also provides the preparation methods of this kind of forefront capsule：All raw materials is taken to crush mixing, it is auxiliary to add in dissolving
Material, then delays the flexible glue cyst fluid of rubber aging to carry out mixing pelleting with described, dry, smears ball to get to the forefront capsule.
Raw material effect that forefront capsule of the present invention is related to：
Chinese violet：Chinese violet mildly bitter flavor cold in nature, there is the effect of clearing heat and detoxicating.Cure mainly jaundice, dysentery, mastitis, mesh
Red swelling and pain, pharyngitis；Traumatic injury, carbuncle swells, venomous snake bite are controlled in external application；And the aesculetin that Chinese violet is rich in have significantly relieving asthma
Activity has loose tracheal smooth muscle and antihistaminicum effect, can play calm, anticonvulsion, analgesia, diuresis and promote uric acid row
The effects that letting out.
Honeysuckle：Sweet in flavor cold in nature, return lung, the heart, stomach are longer than clearing heat and detoxicating, dispelling wind and heat from the body, to control malignant boil, sore, carbuncle, swelling it
Monarch drug in a prescription.
Wild chrysanthemum：Meridian distribution of property and flavor is bitter, pungent, is slightly cold, Return liver, the heart channel of Hang-Shaoyin, has the function of clearing heat and detoxicating, detumescence, can be extensive
For treating anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furunculosis carbuncle swells, abscess of throat, wind-fire red eye, dizziness of having a headache
Etc. diseases.
Field pennycress：Cool in nature, acrid flavour, hardship have effects that the clearing heat and detoxicating, carbuncle that disappears apocenosis, stasis-dispelling and pain-killing.
Dandelion：It is bitter, sweet, it is cold in nature.It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia, for furuncle swelling toxin, acute mastitis, scrofula
Scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Plantain seed：It is sweet in flavor, it is cold in nature.Return liver, kidney, lung, small intestinl channel.Reducing fever and causing diuresis is treating stranguria, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm.With
In puckery pain of heat gonorrhea, oedema turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough.
The seed of cowherb：Bitter, it is mild-natured.Return liver, stomach.Invigorate blood circulation, lower breast detumescence, inducing diuresis for treating strangurtia.For Amenorrhea, pain
Through, agalactia, acute mastitis swelling and pain, the puckery pain of stranguria.
Radix Codonopsis：It is sweet in flavor, it is mild-natured.There is tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.For spleen-lung Qi deficiency, deficiency of food is tired
It is idle, false asthma cough, insufficiency of vital energy and blood, sallow complexion, palpitation, injury thirst, Heat Diabetes.
Frankincense, acrid flavour is bitter, temperature.Enter the heart, liver, the spleen channel.Regulating qi and activating blood, analgesic therapy chase after poison.
Myrrh, it is bitter, it is pungent, it puts down.Enter liver, spleen, the heart, kidney channel.Dissipate blood stasis eliminatings, detumescence ding-tong.
Radix Angelicae Pubescentis, acrid flavour, hardship, temperature；Enter lung, spleen, kidney three to pass through, there is the benefits of dispelling wind removing toxic substances, promoting blood circulation, analgesic.
Corydalis tuber：Position is pungent, bitter, warm-natured.Return liver, the spleen channel.Promoting blood circulation, promoting the circulation of qi, analgesic.For chest side of body, epigastric pain, the obstruction of qi in the chest heart
Bitterly, closed dysmenorrhea, postpartum stasis, tumbling and swelling.
Cordate houttuynia：It is pungent, it is slightly cold.It is distributed in lung channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm heat panting
Cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Caulis Spatholobi：It is bitter, sweet, it is warm-natured, return liver and kidney channel, there is expansion blood vessel, replenishing and activating blood, menstruation regulating, the work(of relaxing tendons and activating collaterals
Effect, curing mainly the deficiency of blood has the irregular menstruation of silt, and limbs pain is meciless, the cards such as soreness and weakness of waist and knees, pain.
Lepidium seed：Acrid flavour, hardship, it is cold in nature.Enter lung, bladder, large intestine channel.Purging the lung of pathogenic fire sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema expel the heat-evil
By heresy.Cure mainly the dyspnea and cough with excessive sputum of sputum stop up lung, lung carbuncle, oedema, chest and abdomen ponding, difficult urination, chronic cor pulmonale, mental and physical efforts
The asthma of failure is swollen.Also ulcer malignant sore, scrofula tuberculosis are controlled.
The present invention is using Chinese violet, honeysuckle and wild chrysanthemum as monarch, the benefits of playing clearing heat and detoxicating, antibacterial anti-inflammatory, with field pennycress,
Dandelion, plantain seed and the seed of cowherb be minister, enhance monarch drug in a prescription the benefits of, and make the present invention forefront capsule have clearing away heat and promoting diuresis,
The benefits of promoting blood circulation and removing blood stasis, dredging collateral menstruation regulating, tests through modern pharmacodynamic study, available for treating various prostatitis, is particularly suitable for
Chronic prostatitis, Radix Codonopsis, frankincense, myrrh, Radix Angelicae Pubescentis make for assistant, frankincense, the myrrh promoting flow of qi and blood circulation, strengthen the therapeutic effect of the monarch and his subjects,
Radix Codonopsis and Radix Angelicae Pubescentis regulating the function of the liver and spleen lung after improving curative effect, can mitigate pharmacological property, and human body is made faster to restore to defend oneself defence and from net energy
Power, reduction the monarch and his subjects are strong, are entirely formulated reasonable compatibility, through dialectical compatibility, help, play altogether clearing heat and detoxicating, clear using mutually assistant
It is the benefits of hot Li Shui, promoting blood circulation and removing blood stasis, dredging collateral menstruation regulating, significant in efficacy reliable for treating various prostatitis.
The present invention further preferably adds in corydalis tuber, cordate houttuynia, Caulis Spatholobi and lepidium seed are minister, play altogether it is clearing heat and detoxicating it
It is remaining, the benefits of replenishing and activating blood, inducing diuresis for removing edema, stasis-dispelling and pain-killing can be enhanced, the effect of so as to enhance to various prostatitis.
The beneficial effects of the present invention are：1st, the present invention is used as moisturizer by adding the sorbierite of proper ratio, coordinates
The plasticizer effect of glycerine, delays the rubber aging of soft capsule, and the indexs such as capsule and pill disintegration time limited and dissolution accord in Storage period
Requirement is closed, is improved stability and the shelf-life of Chinese medicinal soft capsule, disintegration stability is 24 months；2nd, soft capsule of the invention
Glue and soft capsule preparation method are simple and practical, and controllability is strong, suitable for industrialized production；3rd, forefront capsule provided by the invention
Using Chinese violet, honeysuckle and wild chrysanthemum as monarch, the benefits of playing clearing heat and detoxicating, antibacterial anti-inflammatory, with field pennycress, dandelion, plantain seed
The benefits of being minister with the seed of cowherb, enhancing monarch drug in a prescription, and make the forefront capsule of the present invention that there is clearing away heat and promoting diuresis, promoting blood circulation and removing blood stasis, dredging collateral
The benefits of menstruation regulating, tests through modern pharmacodynamic study, available for treating various prostatitis, is particularly suitable for chronic prostatitis；
4th, forefront capsule preparation method thereof of the invention is simple and practical, and controllability is strong, and suitable for industrialized production, the storage of forefront capsule is steady
It is qualitative good, it is sustained stable effect.
Specific embodiment
For the ease of the understanding of those skilled in the art, with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Embodiment 2
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Embodiment 3
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Embodiment 4
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Embodiment 5
A kind of flexible glue cyst fluid for delaying rubber aging, the flexible glue cyst fluid include the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Comparative example 1
A kind of flexible glue cyst fluid includes the raw material of following parts by weight：
Wherein, the opacifier is titanium dioxide, and the preservative is ethyl hydroxy benzoate.
Embodiment 6 is disintegrated stability test
Soft capsule, the rubber thickness of soft capsule is made with test content in the flexible glue cyst fluid of Example 1-5 and comparative example 1
Control is consistent, by soft capsule be placed in constant temperature and humidity study on the stability chamber respectively at 0 month, 3 months, 6 months, 9 months,
Disintegration time limited detection is carried out respectively within 12 months, 18 months, 24 months, as a result such as following table：
As can be seen from the above table, the soft capsule of present invention addition sorbierite is disintegrated surely than not adding the comparative example 1 of sorbierite
It is qualitative to have a degree of deduction, wherein being protruded with the additive amount effect of 8%-15%, disintegration can be still realized at 24 months,
And 10% additive amount effect is the most prominent.
Embodiment 7
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
Embodiment 8
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
Embodiment 9
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
Embodiment 10
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
Embodiment 11
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
Embodiment 12
A kind of forefront capsule, including soft capsule and dress as made from the flexible glue cyst fluid for delaying rubber aging as described above
The Chinese medicine composition being loaded in soft capsule, the Chinese medicine composition include the raw material of following parts by weight：
Wherein, the preparation method of forefront capsule：All raw materials is taken to crush mixing, add in dissolving auxiliary material, then with it is described
The flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting, it is dry, ball is smeared to get to the forefront capsule.
The anxious poison experiment of embodiment 13
4 groups of mouse are taken, every group 10, weight is in 20 ± 2g, each 5 of male and female, fasting 5 hours, the Chinese medicine group of Example 8
Object is closed by 0g/Kg, 20g/Kg, 80g/Kg, 160g/Kg respectively to every group of intragastric administration on mice, mouse activity condition is observed, in 24 hours
Observation 4 times, later observation 2 times daily until 7 days, find mouse administration group and blank group in action, nervous system reaction and autonomous
Behavioral system reacts no significant difference, LED50It is zero.
Embodiment 14
60 male SD rats, 200 grams or so of weight, 0.9% yellow Jackets of intraperitoneal injection are anaesthetized by 0.5ml/100g,
Aseptic condition lower abdomen median incision exposes the prostate notopodium on the inside of bladder and seminal vesicle, and 10 rats of Normal group are in preceding
Row gland notopodium injects 0.2mL/ physiological saline, remaining 50 rat injects 25% XIAOZHILING ZHUSHEYE in prostate notopodium
0.2ml/ only, closes abdomen.50 rats of modeling were randomly divided into 5 groups in postoperative 7th day, every group 10, i.e. model group, positive drug pair
According to group (1g/kg), by reagent low dose group (0.5g/kg), by reagent middle dosage (1.0g/kg), by reagent high dose (3.0g/
Kg), gastric infusion, once a day, successive administration 30 days, wherein, positive drug control group is in commercially available conventional purple Siberian cocklebur capsule
Medicine constituent, reagent group are the Chinese medicine composition of embodiment 8.
TNF-a is the factor for causing systemic inflammatory response earliest, and vascular endothelial cell structure can be caused to change, lead to blood vessel
Endothelial cell damage makes plasma protein and water largely infilter local organization, aggravates local inflammation reaction.IL-8 is low relative molecular
The potent Chemokines of quality are largely generated by macrophage, endothelial cell etc. after inflammatory stimulus, inflammation are further aggravated
Reaction, TNF-a and IL-8 levels are higher, and inflammatory reaction is heavier.
The present invention is monitored by prostate coefficient to mouse, TNF-a and IL-8 levels, obtains the experiment knot of following table
Fruit.
Wherein, * P ＜ 0.05 compared with Normal group, * * the P ＜ 0.01 compared with Normal group.
By more than result of the test it is found that by reagent of the present invention and positive drug can reduce the prostate coefficient of rat with before
TNF-a in row glandular tissue and IL-8 is horizontal, show by reagent and positive drug can mitigate chronic prostatitis inflammation it is anti-
Should, it is effective to chronic prostatitis and hyperplasia, and by reagent effect in low dosage has surmounted positive drug, in suitable dose
Under, curative effect is also more obviously improved.
The dosage for showing Chinese medicine composition in every Chinese violet capsule of the invention through clinical test is preferably 0.3g, every time
2-4 are preferably taken, takes frequency as 3 times a day.
15 clinical test of embodiment
Take 2 groups of patients with chronic prostatitis, every group 100, every group of difference Application Example 8 and control group purple Siberian cocklebur capsule into
Row treatment, the wherein Chinese medicine composition of every capsule of embodiment 8 are 0.3g, and each patient per takes 3,3 times a day, control
Person is taken by the frequency of the operation instruction of purple Siberian cocklebur capsule, and after treating 3 weeks, curative effect judgements are carried out using 4 grades of standards.
4 grades of standards are as follows：
Recovery clinical improvement rate >=95%；
Effective clinical improvement rate ＜ 95%, >=60%；
Effective clinical improvement rate ＜ 60%, >=20%；
Invalid clinical improvement rate ＜ 20%.
Treatment results see the table below：
| Recovery from illness/example | Effective/example | Effectively/example | In vain/example | It is efficient | |
| Embodiment 8 | 25 | 42 | 23 | 10 | 90% |
| Control group | 19 | 37 | 24 | 20 | 80% |
As seen from the above table, forefront capsule of the invention is significant in efficacy to chronic prostatitis, treats three weeks, treated effect
Up to 90%.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other manner,
Any obvious replacement is not departed under the premise of present inventive concept within protection scope of the present invention.
Claims (10)
1. a kind of flexible glue cyst fluid for delaying rubber aging, it is characterised in that：The flexible glue cyst fluid includes the raw material of following parts by weight：
2. a kind of flexible glue cyst fluid for delaying rubber aging according to claim 1, it is characterised in that：The capsule liquid is by such as
The raw material composition of lower parts by weight：
3. a kind of flexible glue cyst fluid for delaying rubber aging according to claim 1, it is characterised in that：The opacifier is two
Titanium oxide.
4. a kind of flexible glue cyst fluid for delaying rubber aging according to claim 1, it is characterised in that：The preservative is hydroxyl
Phenethyl ester.
5. a kind of described in claim 1-4 any one delays the preparation method of the flexible glue cyst fluid of rubber aging, feature exists
In：Include the following steps：
(1) opacifier and a part of water is taken to be ground dispersion, obtains shading agent dispersing liquid；
(2) pigment is taken to be dissolved in another part water, obtains pigment solution；
(3) glycerine, sorbierite and remaining water are mixed, and be heated to 40-80 DEG C, sequentially add shading agent dispersing liquid, color
Plain solution, gelatin and preservative, stirring and dissolving, vacuumizing and exhausting bubble is to get to the capsule liquid.
6. a kind of forefront capsule, it is characterised in that：Including as delaying the soft of rubber aging described in claim 1-4 any one
Soft capsule made from capsule liquid and the Chinese medicine composition being loaded into soft capsule, the Chinese medicine composition include following parts by weight
Several raw materials：
7. a kind of forefront capsule according to claim 6, it is characterised in that：The Chinese medicine composition further includes following weight
The raw material of number：
8. a kind of forefront capsule according to claim 7, it is characterised in that：The Chinese medicine composition is by following parts by weight
Raw material composition：
9. a kind of forefront capsule according to claim 8, it is characterised in that：The Chinese medicine composition is by following parts by weight
Raw material composition：
10. a kind of preparation method of forefront capsule described in claim 7-9 any one, it is characterised in that：Take all raw materials
Mixing is crushed, adds in dissolving auxiliary material, then the flexible glue cyst fluid of rubber aging is delayed to carry out mixing pelleting with described, it is dry, it smears
Ball is to get to the forefront capsule.
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| CN201711314242.8A CN108210477A (en) | 2017-12-12 | 2017-12-12 | Delay flexible glue cyst fluid, soft capsule and the forefront capsule and its preparation method of rubber aging |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336700A (en) * | 2019-08-08 | 2021-02-09 | 河北菲尼斯生物技术有限公司 | Stable butylphthalide-containing medicine and preparation method thereof |
| CN113559079A (en) * | 2020-04-28 | 2021-10-29 | 江苏恒瑞医药股份有限公司 | Soft capsule and preparation method and application thereof |
| CN114642695A (en) * | 2020-12-17 | 2022-06-21 | 华子昂 | Big data traditional Chinese medicine composition for regulating and controlling prostate cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188524A (en) * | 2011-05-10 | 2011-09-21 | 孙文杰 | Pharmaceutical for treating prostatitis and preparation method thereof |
| CN104257627A (en) * | 2014-10-23 | 2015-01-07 | 广东广发制药有限公司 | Glue solution for traditional Chinese medicine soft capsule with good stability and preparation method thereof |
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2017
- 2017-12-12 CN CN201711314242.8A patent/CN108210477A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188524A (en) * | 2011-05-10 | 2011-09-21 | 孙文杰 | Pharmaceutical for treating prostatitis and preparation method thereof |
| CN104257627A (en) * | 2014-10-23 | 2015-01-07 | 广东广发制药有限公司 | Glue solution for traditional Chinese medicine soft capsule with good stability and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336700A (en) * | 2019-08-08 | 2021-02-09 | 河北菲尼斯生物技术有限公司 | Stable butylphthalide-containing medicine and preparation method thereof |
| CN112336700B (en) * | 2019-08-08 | 2023-12-01 | 河北菲尼斯生物技术有限公司 | Stable butylphthalide-containing medicament and preparation method thereof |
| CN113559079A (en) * | 2020-04-28 | 2021-10-29 | 江苏恒瑞医药股份有限公司 | Soft capsule and preparation method and application thereof |
| CN113559079B (en) * | 2020-04-28 | 2023-10-20 | 江苏恒瑞医药股份有限公司 | Soft capsule and preparation method and application thereof |
| CN114642695A (en) * | 2020-12-17 | 2022-06-21 | 华子昂 | Big data traditional Chinese medicine composition for regulating and controlling prostate cancer |
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