CN104548008B - A kind of pharmaceutical composition prevented and/or treat allergic skin diseases and preparation method thereof - Google Patents
A kind of pharmaceutical composition prevented and/or treat allergic skin diseases and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of pharmaceutical composition prevented and/or treat allergic skin diseases and preparation method thereof.The pharmaceutical composition is made up of the raw material of following mass parts：4-16 parts of 6-24 parts of the Radix Astragali, 4-20 parts of the root of herbaceous peony, 4-16 parts of cassia twig, 4-16 parts of ginger, 4-16 parts of almond, windproof 2-10 parts, 1.2-4.8 parts of cicada slough, 2.4-9.6 parts of Exocarpium Citri Rubrum, 5-23 parts of jujube (stoning) and radix glycyrrhizae.One of preparation method comprises the steps：The Radix Astragali, the root of herbaceous peony, cassia twig, ginger, almond, windproof, cicada slough, Exocarpium Citri Rubrum, jujube and the taste medicinal material of radix glycyrrhizae ten are weighed in proportion, extracted, filtered with water, collect filtrate, the filtrate is condensed into the medicinal extract that relative density is 1.05 1.25, obtains described pharmaceutical composition.Use it for treating the allergic skin diseases such as allergic urticaria, allergic eczema, pollen hypersensitivity symptom, have the advantages that evident in efficacy, easy to use, action is rapid, safety is painless.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition prevented and/or treat allergic skin diseases and preparation method thereof.
Background technology
Anaphylactia, allergic disease is called, is current most common a kind of chronic disease.It shows as human body
Too strong immune response is produced to one or more materials in environment, and causes the damage of tissue and organ, it is normal so as to influence
Physiological function.Anaphylactia has a nature process progressively deteriorated, involves more tissue and organ, can also be concurrently other
Disease, or even threat to life.Type Ⅰ hypersensitivity reaction is a kind of common allergic reaction, and predominantly respiratory tract anaphylaxis react, disappeared
Change road allergic reaction, cutaneous anaphylaxis and anaphylactic shock.The illness of performance is mainly allergic rhinitis, anaphylaxis heavy breathing
Asthma, allergic enterogastritis and anaphylaxis dermatosis.
Anaphylaxis dermatosis are the skin diseases as caused by anaphylactogen, and specific anaphylactogen can be divided into contact allergy original, inhale
Enter anaphylactogen, eat anaphylactogen and be injected into the class of anaphylactogen four.It can cause corresponding anaphylaxis dermatosis per class anaphylactogen.
It is mainly shown as red swelling of the skin, itching, pain, nettle rash, eczema, macula, papule, wheal fash etc..
(1) eczema, which has, substantially oozes out.The incidence of disease of eczema has the trend of rising in recent years, this abuse with chemicals,
The factors such as environmental pollution, the disposal of three wastes are not good at, rhythm of life is accelerated, stress increases are relevant.Characteristics of incidence：Any age is equal
It can fall ill；Any position of body surface can be betided；Recurrent exerbation；Locally or systemically visible erythema, papule, bubble, erosion, ooze
Go out, form a scab, furfur, pigmentation；Violent itch.
(2) nettle rash (wheal, wheal) defines：Body is to all kinds of stimulations in a kind of angioneurotic of cutaneous manifestations
Reaction (the thin vessels expansion of hypodermis, the permeability increase of tube wall, transudation occurs, forms local edema).The cause of disease：(One)
Hot and cold, daylight of external contact etc. stimulates；Mosquito, sting；The plants such as nettle, lacquer tree；(ii) interior contact fish, shrimp, marine product, mushroom
Mushroom, sulfonamides, salicylic acid, penicillin, serum, toxin caused by parasite；(iii) uncomfortable, irregular menstruation, stress,
It is tired, depressed etc.；(iv) household heredity factors (heredity of allergic constitution).Symptom：(i) skin violent itch or burn feeling suddenly.(ii) go out
Rash：There is rapidly edema wheal differ in size, that limitation is block in affected part, small to arrive the grain of rice, common to be greatly to hand size
Nail is to coin-size, slightly above surrounding skin.
(3) performance of food hypersenstivity food hypersenstivity can be diversified that fash is most commonly seen, face of mostly occurring, mouth
The erythema in week, trunk is also more common, itch furfur, and can have pigmentation.Separately there is one kind, after edible edible wild herbs, through daylight
Irradiation skin may occur in which photosensitive dermatitis, and chronic edema, malaise, nausea, diarrhoea, stomachache is presented in face neck hand.Caused
Quick common food has seafood (especially shellfish), bamboo shoot, mushroom, milk, tomato, barley, edible wild herbs, fruit, kernel, soybean, flower
Life, chocolate etc., but cause allergy sometimes and non-food in itself, but disinfectant, preservative etc..
(4) cosmetic allergic contact dermatitis cosmetics can cause red skin, swollen, hot, pain, the allergy such as get blister.Said from medical angle,
If it find that to certain cosmetic allergic contact dermatitis, do not have to preferably.But sometimes but it is be unable to do without in living, such as the elderly's hair dyeing and occupation
Women's is light make-up.At this moment most scientific method is fundamentally to improve allergic constitution.
Treatment of the traditional Chinese medical science for anaphylaxis dermatosis is broadly divided into three directions：It is drug therapy first, principle of reatment
First to use the sensible medicine of heat clearing and blood circulation promoting, it is after symptom improves, then imposes the agent of strengthening spleen, tonifying kidney, to strengthen the body resistance to consolidate the constitution as target,
The immunocompetence of patient is lifted, makes it the purpose cured because immunocompetence improves.
Therefore the treatment anaphylaxis that a kind of energy rapid relief of symptoms, cure rate height, recurrence rate are low and have no adverse reaction is developed
The medicine of disease of skin, there is actual application value and major and immediate significance.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition prevented and/or treat allergic skin diseases and its preparation
Method.The pharmaceutical composition has well to allergic skin diseases such as allergic urticaria, allergic eczema, pollen hypersensitivity symptoms
Curative effect.
Pharmaceutical composition provided by the present invention is made up of the raw material of following mass parts：6-24 parts of the Radix Astragali, the root of herbaceous peony 4-20
Part, 4-16 parts of cassia twig, 4-16 parts of ginger, 4-16 parts of almond, windproof 2-10 parts, 1.2-4.8 parts of cicada slough, Exocarpium Citri Rubrum 2.4-
4-16 parts of 9.6 parts, 5-23 parts of jujube (stoning) and radix glycyrrhizae.
Concretely 6-24 parts, 9-21 parts, 12-18 parts, 13-17 parts of the mass parts of the Radix Astragali；The root of herbaceous peony
Concretely 4-20 parts, 5-19 parts, 9-15 parts, 10-14 parts of mass parts；The mass parts of the cassia twig concretely 4-16
Part, 6-14 parts, 8-12 parts, 9-11 parts；Concretely 4-16 parts of the mass parts of the ginger, 6-14 parts, 8-12 parts,
9-11 parts；Concretely 4-16 parts, 6-14 parts, 8-12 parts, 9-11 parts of the mass parts of the almond；The windproof matter
Measure concretely 2-10 parts, 3-9 parts, 4-8 parts, 5-7 parts of part；Concretely 1.2-4.8 parts of the mass parts of the cicada slough,
1.8-4.2 parts, 2.4-3.6 parts, 2.6-3.4 parts；Concretely 2.4-9.6 parts of the mass parts of the Exocarpium Citri Rubrum, 3.6-8.4
Part, 4.8-7.2 parts, 5.2-6.8 parts；Concretely 5-23 parts of the mass parts of the jujube (stoning), 8-20 parts, 11-17
Part, 12-16 parts；Concretely 4-16 parts, 6-14 parts, 8-12 parts, 9-11 parts of the mass parts of the radix glycyrrhizae.
Described pharmaceutical composition further can be made up of the following raw material：9-21 parts of the Radix Astragali, 5-19 parts of the root of herbaceous peony, cassia twig 6-
14 parts, 6-14 parts of ginger, 6-14 parts of almond, windproof 3-9 parts, 1.8-4.2 parts of cicada slough, 3.6-8.4 parts of Exocarpium Citri Rubrum, jujube (go
Core) 8-20 parts and 6-14 parts of radix glycyrrhizae.
Described pharmaceutical composition is further made up of the following raw material：12-18 parts of the Radix Astragali, 9-15 parts of the root of herbaceous peony, cassia twig 8-
12 parts, 8-12 parts of ginger, 8-12 parts of almond, windproof 4-8 parts, 2.4-3.6 parts of cicada slough, 4.8-7.2 parts of Exocarpium Citri Rubrum, jujube
11-17 parts (stonings) and 8-12 parts of radix glycyrrhizae.
Described pharmaceutical composition is also further made up of the following raw material：13-17 parts of the Radix Astragali, 10-14 parts of the root of herbaceous peony, cassia twig
9-11 parts, 9-11 parts of ginger, 9-11 parts of almond, windproof 5-7 parts, 2.6-3.4 parts of cicada slough, 5.2-6.8 parts of Exocarpium Citri Rubrum, jujube
12-16 parts (stonings) and 9-11 parts of radix glycyrrhizae.
Described pharmaceutical composition is most preferably made up of the following raw material：15 parts of the Radix Astragali, 12 parts of the root of herbaceous peony, 10 parts of cassia twig, ginger 10
10 parts of part, 10 parts of almond, windproof 6 parts, 3 parts of cicada slough, 6 parts of Exocarpium Citri Rubrum, 14 parts of jujube (stoning) and radix glycyrrhizae.
Each bulk drug that pharmaceutical composition of the present invention is made is to be used as to match according to mass parts, can be according to corresponding in production
Ratio increase or reduce, as large-scale production can by kilogram or in units of ton, small-scale production can also be with gram to be single
Position, weight can increase or reduce, but the bulk drug quality proportioning constant rate between each composition.
Preparing the method for aforementioned pharmaceutical compositions includes following three kinds of methods：
Method one, comprises the steps：
1) by the quality parts ratio weigh the Radix Astragali, the root of herbaceous peony, cassia twig, ginger, almond, windproof, cicada slough, Exocarpium Citri Rubrum, jujube and
The taste medicinal material of radix glycyrrhizae ten, extraction is added water to cook, collect extract solution；
2) extract solution is condensed into clear cream, let cool, ethanol or ethanol water are then added in the clear cream makes
Alcohol volume content reaches 30-70%, stirs evenly, and stands；Standing collects supernatant and reclaims ethanol after terminating, that is, obtains described
Pharmaceutical composition.
The pharmaceutical composition decoction directly can take or add appropriate flavouring and/or pure water and oral liquid is made.
Wherein, the water added in step 1) is 5-10 times of the medicinal material gross mass；The decoction extraction can be carried out
1-3 times, the time for decocting extraction every time can be 1-3 hours.Medicinal material employed in step 1) is the medicinal material after net system.Institute
State the preferred Radix Glycyrrhizae (processed with honey) of radix glycyrrhizae；The preferred semen armeniacae amarae of almond；Cicada slough is also referred to as periostracum cicada.
Clear cream is the clear cream that the relative density of 70 DEG C of measure is 1.05-1.25 in step 2)；Second in the ethanol water
The volumn concentration of alcohol concretely 60-95%；The time of the standing can be 12-96 hours.
Method two, comprises the steps：
The Radix Astragali, the root of herbaceous peony, cassia twig, ginger, almond, windproof, cicada slough, Exocarpium Citri Rubrum, jujube and radix glycyrrhizae ten are weighed by quality parts ratio
Taste medicinal material, the ethanol water that above-mentioned medicinal material is 50-95% with volumn concentration is extracted, after extraction, filtration,
Filtrate is collected, reclaims ethanol, filtrate is condensed into the thick paste (70 DEG C) that relative density is 1.10~1.40, obtains the medicine group
Compound.
Wherein, extraction can be refluxing extraction described in step.When using refluxing extraction, the extraction at least carries out one
It is secondary, preferably extract 1-3 times, the time extracted every time can be 1-3 hours；Every time during extraction, the addition quality of Extraction solvent is institute
State quality of medicinal material 5-10 times.
The extraction or cold soaking extraction or seepage pressure effects.It is used when using cold soaking extraction method or permeating extraction
Extraction solvent preferred volume percentage composition be 60-85% ethanol water.When cold soaking extracts, the addition quality of Extraction solvent
It is 5-10 times of the medicinal material gross mass；The concretely 7-15 days time of cold soaking extraction.During seepage pressure effects, Extraction solvent adds
Enter 5-12 times that quality is the medicinal material gross mass.
Method three, comprises the steps：
The Radix Astragali, the root of herbaceous peony, cassia twig, ginger, almond, windproof, cicada slough, Exocarpium Citri Rubrum, jujube and sweet are weighed by the quality parts ratio
Careless ten taste medicinal materials, are extracted with water, are filtered, and collect filtrate, and the filtrate is condensed into the leaching that relative density is 1.05-1.25
Cream, obtain described pharmaceutical composition.
Wherein, the extraction can be refluxing extraction, and the extraction is typically at least carried out once, and the time extracted every time is 1-
3.5 hour.During the extraction, the mass ratio of medicinal material and water is 1：5-10.
Above-mentioned three kinds of methods, in order to further obtain the medicine of solid-state, methods described also includes：By described pharmaceutical composition
The thick paste that 70 DEG C of measure relative densities are 1.10-1.35 is condensed into, dry, pulverize, 80-120 mesh sieves is crossed, obtains drug regimen
The step of thing powder.Or concentrate described pharmaceutical composition, add auxiliary material and granule is made or by described pharmaceutical composition powder
Add auxiliary material that granule is made.
Pharmaceutical composition prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.
It is also another object of the present invention to provide the application of described pharmaceutical composition.
The application of pharmaceutical composition provided by the present invention is its answering in treatment allergic skin diseases medicine is prepared
With.
The allergic skin diseases include allergic urticaria, allergic eczema, pollen hypersensitivity symptom etc..
Protection scope of the present invention is fallen within by medicine made of active component of aforementioned pharmaceutical compositions.By will be above-mentioned
Pharmaceutical composition, prepare, can be made into any pharmaceutically acceptable after directly preparing or adding pharmaceutically acceptable auxiliary material
Formulation.Include by taking oral formulations as an example：It is capsule, tablet, granule, powder, pill, pill, sustained-release preparation, oral
Liquid, mixture and syrup；Include by taking external preparation as an example：Ointment, suppository, patch, vina, tincture, gel, liniment, gas
Mist agent, spray and plastics.The medicine of above-mentioned various formulations can be prepared according to the conventional method of pharmaceutical field.
In clinical practice, the dosage of medicine is generally 5-50g/ days as active ingredients, and the course for the treatment of is generally 7-14 days.
The present invention is pure Chinese medicinal preparation, wherein, the Radix Astragali has a tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid,
The stagnant logical numbness of row, the effect of pus draining and toxin expelling；The root of herbaceous peony has nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, the effect of suppressing liver-YANG；Osmanthus
Branch has sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, the effect of flat gas that spins；Ginger has relieving exterior syndrome and dispelling cold, the work of preventing phlegm from forming and stopping coughing
With；Almond has the function that sending down abnormally ascending is relieving cough and asthma；It is windproof have expel pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion；Cicada slough has evacuation wind
Heat, relieving sore-throat, promoting eruption, removing nebula, the effect of spasmolysis；Exocarpium Citri Rubrum has regulating the flow of QI to ease the stomach, eliminating dampness and eliminating phlegm effect；Jujube has bowl spares
QI invigorating, the effect of nourishing blood and tranquilization；Radix glycyrrhizae, which has, invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, the effect of coordinating the drug actions of a prescription.We system
Add and subtract and form on the basis of Guizhi decoction closes Yupingfeng San as basic side, there is the effect of harmonizing yingfen and weifen is defended with solid table.We use
In allergic skin diseases such as allergic urticaria, allergic eczema, pollen hypersensitivity symptoms, there is rapid relief of symptoms, curative effect to show
The advantages that writing, be easy to use, safe painless.The medicine had both avoided some side effects of Western medicine, overcame traditional Chinese medicine treatment again
The defects of effect is slow, high recurrence rate, has important actual application value.
Embodiment
Below by specific embodiment, the present invention will be described, but the invention is not limited in this.
Experimental method described in following embodiments, it is conventional method unless otherwise specified；The solvent and auxiliary material, such as
Without specified otherwise, commercially obtain.
The Radix Astragali used in following embodiments, the root of herbaceous peony, cassia twig, ginger, semen armeniacae amarae, windproof, cicada slough, Exocarpium Citri Rubrum, jujube and sweet
Grass meets the pertinent regulations under each medicinal material item of text of Chinese Pharmacopoeia (version in 2010).Before feeding intake, pass through identification, each taste medicine
Material material object is consistent with title, and quality meets standard.
Embodiment 1, the granule for preparing Chinese medicine composition
Take the 75g Radixs Astragali, the 60g root of herbaceous peonys, 50g cassia twig, 50g gingers, 50g semen armeniacae amaraes, 30g windproof, 15g cicada sloughs, 30g Exocarpium Citri Rubrums,
Medicinal material after 70g jujubes (stoning) and the taste net system of 50g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 6 times of medicinal material gross mass, extraction time are respectively 3 hours and 2 hours, every time after extraction, filter, close
And filtrate is concentrated into clear cream of the relative density for 1.10 (70 DEG C of surveys), lets cool, adding the ethanol of 80% (volumn concentration) makes
Alcohol content stirs evenly up to 50% (volumn concentration), stands 48 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into phase
It is the thick paste of 1.20 (70 DEG C of surveys) to density, dry, pulverize, cross 80-120 mesh sieves, add appropriate dextrin and flavouring, mix,
With alcohol granulation, dry, whole grain, produce granule.
Embodiment 2, the capsule for preparing Chinese medicine composition
Take the 150g Radixs Astragali, the 120g root of herbaceous peonys, 100g cassia twig, 100g gingers, 100g semen armeniacae amaraes, 60g windproof, 30g cicada sloughs, 60g
Medicinal material after Exocarpium Citri Rubrum, 140g jujubes (stoning) and the taste net system of 100g radix glycyrrhizaes (honey is processed) ten, the total matter of medicinal material is added into above-mentioned medicinal material
The water of 10 times of amount, extraction 3 hours is decocted, after extraction, filtration, filtrate is concentrated into relative density as the clear of 1.15 (70 DEG C of surveys)
Cream, let cool, adding the ethanol of 90% (volumn concentration) makes alcohol content stir evenly up to 60% (volumn concentration), stand 24
Hour, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into thick paste of the relative density for 1.25 (70 DEG C of surveys), dry, pulverize, mistake
80-120 mesh sieves, the starch and 0.01 times of talcum powder of 0.08 times of gained medicinal powder quality are added, is mixed, with alcohol granulation, done
It is dry, load capsule, produce.
Embodiment 3, the capsule for preparing Chinese medicine composition
Take the 120g Radixs Astragali, the 20g root of herbaceous peonys, 80g cassia twig, 20g gingers, 80g semen armeniacae amaraes, 10g windproof, 24g cicada sloughs, 12g Exocarpium Citri Rubrums,
Medicinal material after 115g jujubes (stoning) and the taste net system of 20g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, adds water
Amount is respectively 8 times and 6 times of quality of medicinal material, and extraction time is respectively 3 hours and 2 hours, every time after extraction, filters, closes
And filtrate is concentrated into clear cream of the relative density for 1.15 (70 DEG C of surveys), lets cool, adding the ethanol of 70% (volumn concentration) makes
Alcohol content stirs evenly up to 40% (volumn concentration), stands 12 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into phase
It is the thick paste of 1.35 (70 DEG C of surveys) to density, dry, pulverize, cross 80-120 mesh sieves, obtain Chinese medicine composition medicinal powder.Add gained
The starch and 0.05 times of talcum powder that 0.1 times of medicinal powder quality, mix, granulation, load capsule, obtain capsule.
Embodiment 4, the oral liquid for preparing Chinese medicine composition
Take the 30g Radixs Astragali, the 100g root of herbaceous peonys, 20g cassia twig, 80g gingers, 20g semen armeniacae amaraes, 50g windproof, 6g cicada sloughs, 48g Exocarpium Citri Rubrums,
Medicinal material after 25g jujubes (stoning) and the taste net system of 80g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 7 times of quality of medicinal material, extraction time is respectively 2 hours, every time after extraction, filtration, and merging filtrate concentration
To the clear cream that relative density is 1.10 (70 DEG C of surveys), let cool, adding the ethanol solution of 80% (volumn concentration) makes alcohol content
Up to 50% (volumn concentration), stir evenly, stand 36 hours, take supernatant to reclaim ethanol to the greatest extent, add flavouring, add pure water
To 600ml, mix, stand, filtration, be distributed into 60 bottles.
Embodiment 5, the oral liquid for preparing Chinese medicine composition
Take the 120g Radixs Astragali, the 100g root of herbaceous peonys, 20g cassia twig, 20g gingers, 20g semen armeniacae amaraes, 50g windproof, 24g cicada sloughs, 12g tangerines
Medicinal material after red, 25g jujubes (stoning) and the taste net system of 80g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 3 times, added
Water is respectively 8 times, 6 times and 5 times of quality of medicinal material, and extraction time is respectively 2 hours, 2 hours and 1 hour, has been extracted every time
Bi Hou, filtration, merging filtrate are concentrated into clear cream of the relative density for 1.10 (70 DEG C of surveys), let cool, adding 60%, (volume basis contains
Amount) ethanol alcohol content is stirred evenly up to 30% (volumn concentration), stand 96 hours, take supernatant to reclaim ethanol to the greatest extent, add
Enter flavouring, add pure water to mix, stand, filtration, be distributed into 90 bottles to 900ml.
Embodiment 6, the tablet for preparing Chinese medicine composition
Take the 45g Radixs Astragali, the 25g root of herbaceous peonys, 70g cassia twig, 70g gingers, 30g semen armeniacae amaraes, 15g windproof, 21g cicada sloughs, 42g Exocarpium Citri Rubrums,
Medicinal material after 40g jujubes (stoning) and the taste net system of 70g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 6 times of quality of medicinal material, extraction time are respectively 3 hours and 2 hours, every time after extraction, filter, merge
Filtrate is concentrated into clear cream of the relative density for 1.08 (70 DEG C of surveys), lets cool, adding the ethanol of 90% (volumn concentration) makes to contain
Alcohol amount stirs evenly up to 50% (volumn concentration), stands 60 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into relatively
Density is the thick paste of 1.25 (70 DEG C of surveys), dry, pulverize, crosses 80-120 mesh sieves, adds the starch of 0.2 times of gained medicinal powder quality,
Mix, granulation, be pressed into tablet, produce.
Embodiment 7, the tablet for preparing Chinese medicine composition
Take the 105g Radixs Astragali, the 95g root of herbaceous peonys, 30g cassia twig, 30g gingers, 70g semen armeniacae amaraes, 45g windproof, 21g cicada sloughs, 42g Exocarpium Citri Rubrums,
Medicinal material after 100g jujubes (stoning) and the taste net system of 30g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, adds water
Amount is respectively 8 times and 6 times of quality of medicinal material, and extraction time is respectively 3 hours and 1 hour, every time after extraction, filters, closes
And filtrate is concentrated into clear cream of the relative density for 1.25 (70 DEG C of surveys), lets cool, adding the ethanol of 70% (volumn concentration) makes
Alcohol content stirs evenly up to 40% (volumn concentration), stands 72 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into phase
It is the thick paste of 1.15 (70 DEG C of surveys) to density, dry, pulverize, cross 80-120 mesh sieves, add the shallow lake of 0.2 times of gained medicinal powder quality
Powder, mix, granulation, be pressed into tablet, produce.
Embodiment 8, the tablet for preparing Chinese medicine composition
Take the 45g Radixs Astragali, the 95g root of herbaceous peonys, 30g cassia twig, 70g gingers, 30g semen armeniacae amaraes, 45g windproof, 9g cicada sloughs, 42g Exocarpium Citri Rubrums,
Medicinal material after 40g jujubes (stoning) and the taste net system of 30g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 3 times, amount of water
Respectively 8 times, 6 times and 5 times of quality of medicinal material, extraction time are respectively 3 hours, 2 hours and 1 hour, every time after extraction,
Filtration, merging filtrate are concentrated into clear cream of the relative density for 1.15 (70 DEG C of surveys), let cool, add 80% (volumn concentration)
Ethanol makes alcohol content stand 60 hours up to 30% (volumn concentration), take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into phase
It is the thick paste of 1.15 (70 DEG C of surveys) to density, dry, pulverize, cross 80-120 mesh sieves, add the shallow lake of 0.5 times of gained medicinal powder quality
Powder, mix, granulation, be pressed into tablet, obtain 150.
Embodiment 9, the tablet for preparing Chinese medicine composition
Take the 90g Radixs Astragali, the 45g root of herbaceous peonys, 60g cassia twig, 40g gingers, 60g semen armeniacae amaraes, 20g windproof, 18g cicada sloughs, 24g Exocarpium Citri Rubrums,
Medicinal material after 85g jujubes (stoning) and the taste net system of 40g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 and 6 times of quality of medicinal material, extraction time are respectively 3 and 2 hours, every time after extraction, are filtered, merging filtrate is dense
Clear cream of the relative density for 1.05 (70 DEG C of surveys) is reduced to, is let cool, adding the ethanol of 95% (volumn concentration) reaches alcohol content
70% (volumn concentration), is stirred evenly, and stands 96 hours, takes supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into relative density and is
The thick paste of 1.35 (70 DEG C of surveys), dry, pulverize, cross 80-120 mesh sieves, add the starch of 0.3 times of gained medicinal powder quality, mix,
Granulation, is pressed into tablet, produces.
Embodiment 10, the tablet for preparing Chinese medicine composition
Take the 60g Radixs Astragali, the 75g root of herbaceous peonys, 40g cassia twig, 48g gingers, 40g semen armeniacae amaraes, 40g windproof, 12g cicada sloughs, 36g Exocarpium Citri Rubrums,
Medicinal material after 55g jujubes (stoning) and the taste net system of 60g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 3 times, amount of water
Respectively 8 times, 6 times and 5 times of quality of medicinal material, extraction time are respectively 2 hours, 2 hours and 1 hour, every time after extraction,
Filtration, merging filtrate are concentrated into clear cream of the relative density for 1.15 (70 DEG C of surveys), let cool, add 80% (volumn concentration)
Ethanol makes alcohol content stir evenly up to 50% (volumn concentration), stand 72 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is dense
Thick paste of the relative density for 1.25 (70 DEG C of surveys) is reduced to, dry, pulverize, cross 80-120 mesh sieves, add gained medicinal powder quality 0.2
Starch again, mix, granulation, be pressed into tablet, produce.
Embodiment 11, the granule for preparing Chinese medicine composition
Take the 90g Radixs Astragali, the 45g root of herbaceous peonys, 32g cassia twig, 60g gingers, 40g semen armeniacae amaraes, 20g windproof, 18g cicada sloughs, 24g Exocarpium Citri Rubrums,
Medicinal material after 55g jujubes (stoning) and the taste net system of 60g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 6 times of medicinal material gross mass, extraction time are respectively 3 hours and 2 hours, every time after extraction, filter, close
And filtrate is concentrated into clear cream of the relative density for 1.10 (70 DEG C of surveys), lets cool, adding the ethanol of 80% (volumn concentration) makes
Alcohol content stirs evenly up to 50% (volumn concentration), stands 48 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into phase
It is the thick paste of 1.20 (70 DEG C of surveys) to density, dry, pulverize, cross 80-120 mesh sieves, add appropriate dextrin and flavouring, mix,
With alcohol granulation, dry, whole grain, produce granule.
Embodiment 12, the capsule for preparing Chinese medicine composition
Take the 65g Radixs Astragali, the 70g root of herbaceous peonys, 45g cassia twig, 55g gingers, 45g semen armeniacae amaraes, 35g windproof, 13g cicada sloughs, 34g Exocarpium Citri Rubrums,
Medicinal material after 60g jujubes (stoning) and the taste net system of 55g radix glycyrrhizaes (honey is processed) ten, 10 times of medicinal material gross mass is added into above-mentioned medicinal material
Water, extraction 3 hours being decocted, after extraction, filtration, filtrate is concentrated into clear cream of the relative density for 1.15 (70 DEG C of surveys), lets cool,
Adding the ethanol of 90% (volumn concentration) makes alcohol content stir evenly up to 60% (volumn concentration), stand 24 hours, take
Clear liquid reclaims ethanol to the greatest extent, and decoction is concentrated into thick paste of the relative density for 1.25 (70 DEG C of surveys), dry, pulverize, crosses 80-120 mesh
Sieve, the starch and 0.01 times of talcum powder of 0.08 times of gained medicinal powder quality are added, is mixed, with alcohol granulation, dried, load glue
Capsule, produce.
Embodiment 13, the tablet for preparing Chinese medicine composition
Take the 85g Radixs Astragali, the 50g root of herbaceous peonys, 55g cassia twig, 45g gingers, 55g semen armeniacae amaraes, 25g windproof, 17g cicada sloughs, 21g Exocarpium Citri Rubrums,
Medicinal material after 80g jujubes (stoning) and the taste net system of 45g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 6 times of quality of medicinal material, extraction time are respectively 3 hours and 2 hours, every time after extraction, filter, merge
Filtrate is concentrated into clear cream of the relative density for 1.08 (70 DEG C of surveys), lets cool, adding the ethanol of 90% (volumn concentration) makes to contain
Alcohol amount stirs evenly up to 50% (volumn concentration), stands 60 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into relatively
Density is the thick paste of 1.25 (70 DEG C of surveys), dry, pulverize, crosses 80-120 mesh sieves, adds the starch of 0.2 times of gained medicinal powder quality,
Mix, granulation, be pressed into tablet, produce.
Embodiment 14, the tablet for preparing Chinese medicine composition
Take the 65g Radixs Astragali, the 70g root of herbaceous peonys, 55g cassia twig, 45g gingers, 45g semen armeniacae amaraes, 35g windproof, 13g cicada sloughs, 26g Exocarpium Citri Rubrums,
Medicinal material after 80g jujubes (stoning) and the taste net system of 55g radix glycyrrhizaes (honey is processed) ten, above-mentioned medicinal material is added water to cook into extraction 2 times, amount of water
Respectively 8 times and 6 times of quality of medicinal material, extraction time are respectively 3 hours and 1 hour, every time after extraction, filter, merge
Filtrate is concentrated into clear cream of the relative density for 1.25 (70 DEG C of surveys), lets cool, adding the ethanol of 70% (volumn concentration) makes to contain
Alcohol amount stirs evenly up to 40% (volumn concentration), stands 72 hours, take supernatant to reclaim ethanol to the greatest extent, decoction is concentrated into relatively
Density is the thick paste of 1.15 (70 DEG C of surveys), dry, pulverize, crosses 80-120 mesh sieves, adds the starch of 0.2 times of gained medicinal powder quality,
Mix, granulation, be pressed into tablet, produce.
The test of pesticide effectiveness of embodiment 15, the Chinese medicinal composition granules of embodiment 1 treatment allergic dermatitis
Rat is randomly divided into 3 groups by body weight：Control group, nasmil group, the Chinese medicinal granule group of embodiment 1,10/group,
Male and female half and half.Experiment uses preventive administration, the successive administration 14 days before antigen attack.
It is prepared by antiserum：By the four sole injections of root of Chinese trichosanthes aluminium hydroxide suspension, (root of Chinese trichosanthes is sensibiligen, and solvent is commercially available
Mass fraction is 4%~5% gel aluminum hydroxide, and being dissolved in 1mL gel aluminum hydroxides with 5mg roots of Chinese trichosanthes temporarily dissolves.), every
Sole injects 0.1ml, common 0.4ml.10-15 days ripe, eyeball bloodletting about 10ml, centrifuges 15min with 3000 turns/min, takes upper strata
Serum produces antiserum.
Passive sensitization of skin：Experiment each group rat back is lost hair or feathers, backbone both sides respectively take at 2 points, every point away from center line 1.5cm
It is spaced 2cm, area about 1 × 1cm2, totally 4 points.Sero-fast different dilution factors (1 are injected in skin of back respectively:30、1:
40).Quantitative corresponding antigens attack is carried out after 48h.After tail vein injection root of Chinese trichosanthes adds evans blue solution 1mg/kg, 30min
Sacrificed by decapitation.
Observation index：The sero-fast local skin reaction of intracutaneous injection, and it is big to measure the locus coeruleus diameter that evans blue is oozed out
Small (cm).Calculate PCA and suppress percentage (%).
PCA inhibiting rates (%)=(blank control group locus coeruleus diameter-administration group locus coeruleus diameter)/blank control group locus coeruleus diameter
× 100%
Table 1, the influence of the granules of rats PCA of embodiment 1 reactions
Note：Compared with blank control group, * P ＜ 0.05
The result of table 1 shows that pharmaceutical composition of the invention is in antiserum dilution factor 1:When 30, compared with blank control group,
Locus coeruleus diameter is significantly inhibited, is 1 in dilution factor:When 40, still there are inhibitory action but not notable, inhibition and nasmil phase
When.Show, pharmaceutical composition of the invention has significant inhibitory action to type Ⅰ allergy-PCA reactions, prompts the medicine
Composition can be used for the prevention or treatment of allergic dermatitis.
The clinical trial of embodiment 16, traditional Chinese medicine composition for treating allergic urticaria of the invention
Clinical data：Ordinary circumstance this group 30 is out-patient, man 18, female 12；It is 20~55 years old age, average
35.8 years old；The course of disease is most short 2 days, most long 1 month, average 10.8 days, wherein<5 days 13,5 days~1 month 17.
Patient's inclusive criteria：
1st, using itch and transient wheal as main clinic symptoms, development is frequent, the wheal duration more than 24 hours,
Any vestige is not stayed after regression, the course of disease is more than 6 weeks；
2nd, not used glucocorticoid in 1 month, unused Claritin in 2 weeks；
3rd, the age is between 18 years old to 65 years old；
4th, without medicine contraindication person；
Excluded cases standard：
1st, gestation or women breast-feeding their children；
2nd, it is associated with hepatic and renal function exception or has gastritis, gastric ulcer or concurrent infection person；
3rd, taking or having in 2 weeks the medicine person for taking treatment nettle rash；
4th, the nettle rash caused by physical factor or other known reasons.
The standard of curative effect evaluation：
1st, cure：Wheal all disappears, and no itch, dermatograph test are negative, and clinical efficacy index decreased rate is more than etc.
In 90%；
2nd, it is effective：Wheal largely disappears, and slight itch, dermatograph test are negative, and clinical efficacy index decreased rate is big
In equal to 20%.
3rd, it is invalid：Wheal disappears without obvious, and itch is obvious, dermatograph test is negative, and clinical efficacy index decreased rate is small
In 20%.
Test method：Using the granule of embodiment 1, orally, 3 times a day, 1 time 1 bag (every bag of 12g, every gram contains crude drug
2.67g).It is within 1 week 1 course for the treatment of, 1 course for the treatment of of medication.
Treatment results：It is shown in Table 2.
The Granules in Treating nettle rash result of 2 embodiment of table 1 observes (n, %)
Then granule, capsule, tablet of embodiment 2-14 preparations etc. is respectively adopted and carries out the test of pesticide effectiveness.
Granule, orally, 3 times a day, 1 time 1 bag (every bag of 12g, every gram contains crude drug 2.67g), continuous use 7 days.
Capsule, orally, 3 times a day, 3 tablets each time, continuous use 7 days.
Tablet, orally, 3 times a day, 3 tablets each time, continuous use 7 days.
Oral liquid, 3 times a day, each 10ml, continuous use 7 days.
Criterion of therapeutical effect is same as above.
Treatment results：It is shown in Table 3-15.
The capsule treatment nettle rash result observation (n, %) of the embodiment 2 of table 3
The capsule of 4 embodiment of table 3 treatment nettle rash result observation (n, %)
The oral liquid treatment nettle rash result of 5 embodiment of table 4 observes (n, %)
The oral liquid treatment nettle rash result of 6 embodiment of table 5 observes (n, %)
The tablet in treatment nettle rash result of 7 embodiment of table 6 observes (n, %)
The tablet in treatment nettle rash result of 8 embodiment of table 7 observes (n, %)
The tablet in treatment nettle rash result of 9 embodiment of table 8 observes (n, %)
The tablet in treatment nettle rash result of 10 embodiment of table 9 observes (n, %)
The tablet in treatment nettle rash result of 11 embodiment of table 10 observes (n, %)
The Granules in Treating nettle rash result of 12 embodiment of table 11 observes (n, %)
The capsule of 13 embodiment of table 12 treatment nettle rash result observation (n, %)
The tablet in treatment nettle rash result of 14 embodiment of table 13 observes (n, %)
The tablet in treatment nettle rash result of 15 embodiment of table 14 observes (n, %)
From above-mentioned table 2-15, embodiment 1-14 product has good therapeutic effect to nettle rash.
The clinical trial of embodiment 17, traditional Chinese medicine composition for treating allergic eczema of the invention
1st, clinical data：100 patients are randomly choosed, all patients are eczema.Wherein acute eczema 55, it is subacute
Eczema 30, chronic eczema 15.
2nd, diagnostic criteria：
Acute eczema, any position of body surface can occur, morbidity is rapid, and fash is in polymorphy.It is mainly shown as erythema oedema
On the basis of papule, papulo-vesicle, blister, erosion, ooze out, form a scab, damage indefinite border, when serious can general hair whole body, itch
Acutely.
Subacute eczema, after mitigating for acute inflammation, fash is based on small papule, the scales of skin that peel off and incrustation, only a small amount of mound
Bleb, blister and erosion；Skin lesion is more limited to, and itch is still more violent.
Chronic eczema, changed by acute eczema, subacute eczema recurrent exerbation.Show as pachylosis, scratch, knot
Scab, immersion are plump, and part lichenification, pigmentation, periphery has been diffused in papulo-vesicle.
3rd, curative effect judges：Clinical cure is that skin lesion is disappeared or only stays pigmentation completely, and subjective symptoms disappears；Effective is skin
Damage regression more than 70%, subjective symptoms substantially mitigates or disappeared；It is effectively skin lesion regression more than 30%, subjective symptoms mitigates；Nothing
Imitate and disappear for skin lesion less than 30%.
4th, treatment method：The medicine of the oral present invention.
Granule, orally, 3 times a day, 1 time 1 bag (every bag of 12g, every gram contains crude drug 2.67g), continuous use 14 days.
Capsule, orally, 3 times a day, 3 tablets each time, continuous use 14 days.
Tablet, orally, 3 times a day, 3 tablets each time, continuous use 14 days.
Oral liquid, 3 times a day, each 10ml, continuous use 14 days.
Treatment results：It is shown in Table 16-24.
The Granules in Treating eczema result of 16 embodiment of table 1 observes (n, %)
The capsule for treating eczema result of 17 embodiment of table 3 observes (n, %)
The oral liquid treatment eczema result of 18 embodiment of table 4 observes (n, %)
The tablet in treatment eczema result of 19 embodiment of table 6 observes (n, %)
The tablet in treatment eczema result of 20 embodiment of table 7 observes (n, %)
The tablet in treatment eczema result of 21 embodiment of table 9 observes (n, %)
The tablet in treatment eczema result of 22 embodiment of table 10 observes (n, %)
The capsule of 23 embodiment of table 12 treatment eczema result observation (n, %)
The tablet in treatment eczema result of 24 embodiment of table 13 observes (n, %)
From above-mentioned table 16-24, embodiment 1-14 product has good therapeutic effect to eczema.
The clinical trial of embodiment 18, the Chinese medicinal composition granules of embodiment 1 treatment pollen hypersensitivity
Patient's inclusive criteria：There are the patient of pollen hypersensitivity medical history selected 60 the pasts, and fall ill continuous more than 2 years.Each disease
Example nutrition condition is good, and blood glucose, blood fat and hepatic and renal function are in normal range (NR).Wherein male 40, women 20, age range
16~52 years old, average age 31.01 ± 15.11 years old.
Research method：It is divided into treatment group and control group, treatment group 30, control group 30 by randomly assigne.Treatment time
Since pollen period the last week, control group avoids contact with pollen, specially occupy indoor as far as possible, closes the doors and windows to reduce room
The entrance of outer pollen, it is outgoing by being branded as, mouth mask and wear long-sleeved clothing, avoid directly contacting with pollen as far as possible；Control
Treatment group is prevented on the basis of control group plus with the granule of the embodiment of the present invention 1.The granule of embodiment 1, orally, one day
3 times, 1 time 1 bag (every bag of 12g, every gram contains crude drug 2.67g).
There is situation and compared in allergic symptom：In control group 30, there are 90% (27) symptom of pollen hypersensitivity occur, 80%
(24) must be treated by using antihistamine drug.In treatment group 30, there are 30% (9) disease of pollen hypersensitivity occur
Shape, 26.67% (8) must be treated by using antihistamine drug.Compare between two groups of groups, difference has extremely obvious system
Meter learns meaning (P<0.01).
Claims (5)
- A kind of 1. application of pharmaceutical composition in prevention and/or treatment allergic skin diseases medicine is prepared；The medicine group Compound, it is made up of the raw material of following mass parts：6-24 parts of the Radix Astragali, 4-20 parts of the root of herbaceous peony, 4-16 parts of cassia twig, 4-16 parts of ginger, 4-16 parts of almond, windproof 2-10 parts, 1.2-4.8 parts of cicada slough, 2.4-9.6 parts of Exocarpium Citri Rubrum, 5-23 parts of jujube of stoning and radix glycyrrhizae 4-16 parts.
- 2. application according to claim 1, it is characterised in that：The allergic skin diseases include allergic urticaria, Allergic eczema and/or pollen hypersensitivity symptom.
- 3. application according to claim 1 or 2, it is characterised in that：Described pharmaceutical composition by following mass parts raw material It is made：9-21 parts of the Radix Astragali, 5-19 parts of the root of herbaceous peony, 6-14 parts of cassia twig, 6-14 parts of ginger, 6-14 parts of almond, it is windproof 3-9 parts, 6-14 parts of 1.8-4.2 parts of cicada slough, 3.6-8.4 parts of Exocarpium Citri Rubrum, 8-20 parts of stoning jujube and radix glycyrrhizae.
- 4. application according to claim 3, it is characterised in that：Described pharmaceutical composition by following mass parts raw material system Into：12-18 parts of the Radix Astragali, 9-15 parts of the root of herbaceous peony, 8-12 parts of cassia twig, 8-12 parts of ginger, 8-12 parts of almond, windproof 4-8 parts, cicada Slough off 2.4-3.6 parts, 4.8-7.2 parts of Exocarpium Citri Rubrum, 8-12 parts of 11-17 parts of jujube of stoning and radix glycyrrhizae.
- 5. application according to claim 4, it is characterised in that：Described pharmaceutical composition by following mass parts raw material system Into：13-17 parts of the Radix Astragali, 10-14 parts of the root of herbaceous peony, 9-11 parts of cassia twig, 9-11 parts of ginger, 9-11 parts of almond, it is windproof 5-7 parts, 9-11 parts of 2.6-3.4 parts of cicada slough, 5.2-6.8 parts of Exocarpium Citri Rubrum, 12-16 parts of stoning jujube and radix glycyrrhizae.
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| CN104352896A (en) * | 2014-12-05 | 2015-02-18 | 济南高达信息技术有限公司 | Traditional Chinese medicine preparation for treating angioneurotic edema |
| CN106267115A (en) * | 2016-10-02 | 2017-01-04 | 成都市飞龙水处理技术研究所 | A kind of Chinese medicine composition treating anaphylaxis dermatosis and preparation method thereof |
| CN113975320A (en) * | 2021-11-17 | 2022-01-28 | 上海运佳黄浦制药有限公司 | Traditional Chinese medicine composition for resisting skin allergy and preparation method and application thereof |
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| CN104436145B (en) * | 2014-12-25 | 2017-11-03 | 吉林一正药业集团有限公司 | It is a kind of to prevent and/or treatment allergic rhinitis and the pharmaceutical composition of allergic asthma |
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| JPH06279305A (en) * | 1993-03-25 | 1994-10-04 | Kuga Takaaki | Agent for treatment of dermatic disease such as atopic dermatitis |
| CN102294007A (en) * | 2011-08-30 | 2011-12-28 | 杨万明 | Medicament for treating urticaria |
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