CN107233481B - A kind of Chinese medicine composition to invigorate the kidney and stop nocturnal emission, medicinal liquor and its preparation method and application - Google Patents
A kind of Chinese medicine composition to invigorate the kidney and stop nocturnal emission, medicinal liquor and its preparation method and application Download PDFInfo
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- CN107233481B CN107233481B CN201710424772.1A CN201710424772A CN107233481B CN 107233481 B CN107233481 B CN 107233481B CN 201710424772 A CN201710424772 A CN 201710424772A CN 107233481 B CN107233481 B CN 107233481B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention provides a kind of Chinese medicine compositions to invigorate the kidney and stop nocturnal emission, and in parts by weight, component includes：100 200 parts of Morinda officinalis, 100 200 parts of Semen Cuscutae, 40 120 parts of the root of bidentate achyranthes, 40 120 parts of the root bark of Chinese wolf-berry, 50 150 parts of Radix Ophiopogonis, 50 150 parts of dried rehamnnia root and 20 80 parts windproof.The present invention also provides preparing extract and preparation method thereof using the Chinese medicine composition, while additionally providing the medicinal liquor and medicinal liquor preparation method and application of Chinese medicine composition preparation.Chinese medicine composition and its extract and medicinal liquor obtained described in the present invention have the function of kidney tonifying, establishing-Yang, controlling nocturnal emission with astringent drugs, promoting blood circulation.The diseases such as, impotence cold to the waist and knee acid caused by kidney yang virtual loss do not lift, frequent urination, frequent urination at night, the timid dizziness of body are proved effective rapid, and good effect, short treating period is easy to use, without side-effects, and securely and reliably, effective percentage reaches 98% in clinic.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition to invigorate the kidney and stop nocturnal emission, medicinal liquor and preparation method thereof
And application.
Background technology
For the drug of current domestic production to invigorate the kidney and stop nocturnal emission, not lower hundred kinds of brand, but applying to clinical treatment
In and it is effective and nontoxic, without side-effects in, Western medicine be still blank.Such as：The medicines such as jinsuo gujing pills, Guilubushen Tablet
Object, these drugs effect in terms of establishing-Yang or vigour loss is more apparent, but in the aspect less effective that invigorates the kidney and stops nocturnal emission, all there is establishing-Yang
But but all there is no more or less poison and side effect in the general character of controlling nocturnal emission with astringent drugs, especially Western medicine for not kidney tonifying, kidney tonifying, cannot not only cure
Illness, and the hope that patient restores recovery from illness is delayed, enable patient disappointed really.Therefore, people to better efficacy more precisely
There are still demands for the medicine to invigorate the kidney and stop nocturnal emission.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of more efficiently Chinese medicine groups to invigorate the kidney and stop nocturnal emission
Object is closed, energy warming and invigorating kidney Yang strengthens muscles and bones.The present invention also provides the medicinal liquor and preparation method thereof prepared using the Chinese medicine composition
And application.
The first aspect of the invention is to provide a kind of Chinese medicine composition to invigorate the kidney and stop nocturnal emission, in parts by weight, group
Divide and includes：100-200 parts of Morinda officinalis, 100-200 parts of Semen Cuscutae, 40-120 parts of the root of bidentate achyranthes, 40-120 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 50-150
Part, 50-150 parts of dried rehamnnia root and 20-80 parts windproof.
Preferably, in parts by weight, the component of the Chinese medicine composition includes：120-180 parts of Morinda officinalis, Semen Cuscutae
120-180 parts, 60-100 parts of the root of bidentate achyranthes, 50-90 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 70-120 part, 70-120 parts of dried rehamnnia root and windproof 30-
60 parts.
It is further preferred that in parts by weight, the component of the Chinese medicine composition includes：140-160 parts of Morinda officinalis,
140-160 parts of Semen Cuscutae, 70-80 parts of the root of bidentate achyranthes, 60-80 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 90-110 part, 80-100 parts of dried rehamnnia root, Yi Jifang
40-50 parts of wind.
The second aspect of the invention is to provide a kind of Chinese medical extract to invigorate the kidney and stop nocturnal emission, is the alcohol of above-mentioned Chinese medicine composition
Extract.
Third aspect of the present invention is to provide the preparation method of above-mentioned Chinese medical extract, takes above-mentioned Chinese medicine composition, adds second
Alcohol impregnate, leachate drying to get.
The fourth aspect of the invention is to provide Chinese medicine composition or second as described in the first aspect of the present invention
Application of the Chinese medical extract in preparing the drug or health products that invigorate the kidney and stop nocturnal emission described in aspect.
For the dosage form of drug or health products, those skilled in the art can according to the custom and acceptance of user,
Add pharmaceutically acceptable auxiliary material, do piece agent, granule, tea bag, capsule, effervescent tablet, medicinal liquor, tincture, oral solution,
Syrup etc..
The fifth aspect of the invention is to provide a kind of medicinal liquor to invigorate the kidney and stop nocturnal emission, impregnates the first aspect institute of the present invention by wine
The Chinese medicine composition stated is prepared.
Wherein, for the dosage of the wine present invention, there is no particular limitation, and the normal of medicinal liquor may be used in those skilled in the art
It is configured with proportioning, in one preferred embodiment, the proportioning of wine and Chinese medicine composition is：10000-100mL ︰
100g。
The sixth aspect of the invention is to provide a kind of preparation method of the medicinal liquor described in the second aspect of the present invention, in taking
Drug composition, be added wine impregnate to get.
Wherein, for the soaking time present invention, there is no particular limitation, and those skilled in the art can be according to previous experiences
It deals on the merits of each case.In one preferred embodiment, it impregnates at least 10 days.
The present invention has the function of kidney tonifying, establishing-Yang, controlling nocturnal emission with astringent drugs, promoting blood circulation., impotence cold to the waist and knee acid caused by kidney yang virtual loss is not
The diseases such as act, frequent urination, frequent urination at night, the timid dizziness of body are proved effective rapid, and good effect, short treating period is easy to use, without side-effects, safety
Reliably, effective percentage reaches 98% in clinic.
Specific implementation mode
With reference to specific embodiment, the present invention is further illustrated, to more fully understand the present invention.
Embodiment 1
Take Morinda officinalis 150g, Semen Cuscutae 150g, root of bidentate achyranthes 75g, root bark of Chinese wolf-berry 70g, Radix Ophiopogonis 100g, dried rehamnnia root 100g, windproof
45g, is added the ethyl alcohol 1L of volumetric concentration 70-85%, and soak extraction 3 times collects extracting solution, is drying to obtain benefit of the present invention
The Chinese medical extract of kidney controlling nocturnal emission with astringent drugs.
Chinese medical extract obtained above adds pharmaceutically acceptable auxiliary material, does piece agent, granule, tea bag, glue
Wafer, effervescent tablet, medicinal liquor, tincture, oral solution, syrup etc..
Embodiment 2
Take Morinda officinalis 150g, Semen Cuscutae 150g, root of bidentate achyranthes 75g, root bark of Chinese wolf-berry 70g, Radix Ophiopogonis 100g, dried rehamnnia root 100g, windproof
45g is fitted into clean bottle, and white wine 1L is added, seals, and is set at shady and cool drying, is often shaken several times, after 10-15 days i.e.
Obtain medicinal liquor.
Embodiment 3
Take Morinda officinalis 140g, Semen Cuscutae 160g, root of bidentate achyranthes 70g, root bark of Chinese wolf-berry 80g, Radix Ophiopogonis 90g, dried rehamnnia root 100g and windproof
40g is ground into thick end, is fitted into gauze bag, and tying is fitted into clean bottle, and white wine 1L is added, seals, sets shady and cool drying
Place is often shaken several times, up to medicinal liquor after 10-15 days.
Embodiment 4
Take Morinda officinalis 160g, Semen Cuscutae 140g, root of bidentate achyranthes 80g, root bark of Chinese wolf-berry 60g, Radix Ophiopogonis 110g, dried rehamnnia root 80g and windproof
50g is ground into thick end, is fitted into gauze bag, and tying is fitted into clean bottle, and white wine 1L is added, seals, sets shady and cool drying
Place is often shaken several times, up to medicinal liquor after 10-15 days.
Embodiment 5
Take Morinda officinalis 180g, Semen Cuscutae 180g, root of bidentate achyranthes 60g, root bark of Chinese wolf-berry 50g, Radix Ophiopogonis 120g, dried rehamnnia root 120g, Yi Jifang
Wind 30g is fitted into clean bottle, and white wine 1L is added, seals, and is set at shady and cool drying, is often shaken several times, after 10-15 days
That is medicinal liquor.
Embodiment 6
Take Morinda officinalis 120g, Semen Cuscutae 120g, root of bidentate achyranthes 100g, root bark of Chinese wolf-berry 90g, Radix Ophiopogonis 70g, dried rehamnnia root 70g and windproof
60g is ground into thick end, is fitted into gauze bag, and tying is fitted into clean bottle, and white wine 1L is added, seals, sets shady and cool drying
Place is often shaken several times, is medicinal liquor after 10-15 days.
Embodiment 7
Take Morinda officinalis 200g, Semen Cuscutae 100g, root of bidentate achyranthes 40g, root bark of Chinese wolf-berry 120g, Radix Ophiopogonis 50g, dried rehamnnia root 150g, Yi Jifang
Wind 20g is fitted into clean bottle, and white wine 1L is added, seals, and is set at shady and cool drying, is often shaken several times, after 10-15 days
Up to medicinal liquor.
Embodiment 8
Take Morinda officinalis 100g, Semen Cuscutae 200g, root of bidentate achyranthes 120g, root bark of Chinese wolf-berry 40g, Radix Ophiopogonis 150g, dried rehamnnia root 50g, Yi Jifang
Wind 80g is ground into thick end, is fitted into gauze bag, and tying is fitted into clean bottle, and white wine 1L is added, seals, and sets shady and cool dry
Dry place is often shaken several times, is medicinal liquor after 10-15 days.
Animal experiment
SD rats, male, are purchased from certain animal housing of traditional Chinese medicine research institute of city by SPF grades.
Rat is randomly divided into 9 groups, every group 10, i.e. Normal group；Model group；Embodiment 1-5 (0.5ml/kg)；Sun
Property medicine methyltestosterone group (25mg/kg).In addition to Normal group is not processed, remaining each group rat jun gives gossypol acetate 10mL/
Kg (50mg/kg) continuously gives 3 days one time a day.Start to be administered according to group after 4th day, continuous 3 weeks, one time a day.Last
1h abdominal aortic bloods after medicine, radioimmunology survey serum testosterone (T), interstitialcellstimulating hormone (ICSH) (LH), follicle-stimulating hormone
(FSH)；Right side cauda epididymidis is shredded and carries out sperm count, abnormal rate and activity rate measurement after spermatozoa diluent is added.As a result
It is shown in Table 1-2.
By table 1-2 as it can be seen that compared with model group, the present invention can significantly improve the sperm count of rat model, and can obviously drop
The lopsided number of the sperm of low rat model, and significantly raised serum T, hence it is evident that reduce serum Lh and FSH.Illustrate that the present invention has
It is apparent to promote Sperm specific enzyme effect, there is therapeutic effect to Spermatogenesis disturbance.
Table 1 to dyszoospermia rat spermatozoa quality influence (N=10)
Table 2 to dyszoospermia rat blood serum T, LH, FSH influence (N=10)
| Group | T(nmol/L) | LH(IU/L) | FSH(IU/L) |
| Model group | 15.33 | 12.90 | 4.91 |
| Normal group | 29.38 | 6.71 | 2.19 |
| Embodiment 1 | 27.51 | 7.86 | 3.44 |
| Embodiment 2 | 27.42 | 8.33 | 3.52 |
| Embodiment 3 | 27.35 | 8.42 | 3.81 |
| Embodiment 4 | 26.99 | 8.95 | 3.86 |
| Embodiment 5 | 26.84 | 9.10 | 4.01 |
| Methyltestosterone | 27.03 | 8.38 | 3.76 |
Clinical trial result
The diseases patients 200 such as waist and knee acid cold, impotence is not lifted, frequent urination, frequent urination at night, the timid dizziness of body caused by kidney yang virtual loss
Example, wherein male 250, women 50, the oldest is 70 years old, minimum 18 years old；It is 20 days that the course of disease is most short, up to 18
Month.It is daily 3 times oral, 5-15 milliliters each, temperature drink, 30 days as a treatment course.Recovery from illness 135, effective 42, effective 17,
Invalid 4, total effective rate 98%.
Case is enumerated：
(1) Peng so-and-so, man, 28 years old, two weeks came night total urination time and hydrouria, gets up 3-4 times at night, Huan Zhewan
Upper rest is bad, and daytime somnolence is more than, has seriously affected daily life and work.After one course for the treatment of of medicinal liquor for taking the present invention,
Deficiency of the kidney disappears, and gets well.
(2) week so-and-so, man, 45 years old, impotence, sexual deterioration.Patient took the medicinal liquor of the present invention after 30 days, took first
3 courses for the treatment of of medicinal liquor of the present invention, 3 times a day, 15 milliliters every time, symptom is improved, and is then continued and is discontinued after taking 10 courses for the treatment of, through multiple
Inspection display is examined, restores normal, also restores self-confident, follow-up is all gone well so far.
(3) Liu, man, 35 years old, dreaminess 1-2 times weekly of passing out semen after marriage, the same branch of a family premature ejaculation, with dizzy weak, disposition suppression
Strongly fragrant, private parts is moist, is dripped after urine white.It is premature ejaculation and chronic prostatitis after diagnosing.Patient takes one treatment of medicinal liquor of the present invention first
Cheng Hou, premature ejaculation symptom all disappear, and sexual function returns to normal, the rear after treatment through 2 courses for the treatment of again, the premature ejaculation of patient and
Chronic prostatitis is thoroughly cured, follow-up so far there are no recurrence.
Specific embodiments of the present invention are described in detail above, but it is intended only as example, the present invention is simultaneously unlimited
It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and
It substitutes also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by impartial conversion and
Modification, all should be contained within the scope of the invention.
Claims (10)
1. a kind of Chinese medicine composition to invigorate the kidney and stop nocturnal emission, which is characterized in that in parts by weight, composed of the following components：Morinda offcinalis How
Its 100-200 parts, 100-200 parts of Semen Cuscutae, 40-120 parts of the root of bidentate achyranthes, 40-120 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 50-150 part, dried rehamnnia root
50-150 parts and 20-80 parts windproof.
2. Chinese medicine composition according to claim 1, which is characterized in that in parts by weight, component includes：Morinda offcinalis How
Its 120-180 parts, 120-180 parts of Semen Cuscutae, 60-100 parts of the root of bidentate achyranthes, 50-90 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 70-120 part, dried rehamnnia root 70-
120 parts and 30-60 parts windproof.
3. Chinese medicine composition according to claim 2, which is characterized in that in parts by weight, component includes：Morinda offcinalis How
Its 140-160 parts, 140-160 parts of Semen Cuscutae, 70-80 parts of the root of bidentate achyranthes, 60-80 parts of the root bark of Chinese wolf-berry, Radix Ophiopogonis 90-110 part, dried rehamnnia root 80-
100 parts and 40-50 parts windproof.
4. a kind of Chinese medical extract to invigorate the kidney and stop nocturnal emission, which is characterized in that it is the alcohol extracting of Chinese medicine composition described in claim 1
Object.
5. a kind of preparation method of the Chinese medical extract to invigorate the kidney and stop nocturnal emission, which is characterized in that take Chinese traditional medicine composition described in claim 1
Object, be added ethyl alcohol impregnate, leachate drying to get.
6. the Chinese medical extract or power described in Chinese medicine composition, claim 4 according to any one of claim 1-3
Profit requires Chinese medical extract prepared by the preparation method described in 5, the application in preparing the drug or health products that invigorate the kidney and stop nocturnal emission.
7. a kind of medicinal liquor to invigorate the kidney and stop nocturnal emission, which is characterized in that impregnate the Chinese medicine group described in any one of claim 1-3 by wine
Object is closed to be prepared.
8. medicinal liquor according to claim 4, which is characterized in that the proportioning of wine and Chinese medicine composition is：10000-100mL ︰
100g。
9. a kind of preparation method of medicinal liquor as described in claim 4 or 5, which is characterized in that take Chinese medicine composition, steeping in wine is added
Bubble to get.
10. preparation method according to claim 6, which is characterized in that impregnate at least 10 days.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145118A (en) * | 2010-11-17 | 2011-08-10 | 苏州市天灵中药饮片有限公司 | Morinda officinalis wine |
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| CN1186070C (en) * | 2002-10-24 | 2005-01-26 | 河北以岭医药研究院有限公司 | Medicine composition for treating impotence and its prepn |
| CN101062398A (en) * | 2007-05-21 | 2007-10-31 | 王军 | Radix rehmanniae pill for warming kidney |
| CN101559160B (en) * | 2008-04-17 | 2012-07-18 | 王守星 | Oral vigor-benefiting yang-vigorating capsule for curing impotence |
| CN103735825B (en) * | 2013-12-26 | 2016-02-17 | 南京金衡灵生物医药科技有限公司 | Comprehensively regulating Chinese medicine composition and application thereof |
| CN104771573A (en) * | 2015-04-02 | 2015-07-15 | 苑丕吉 | Chinese herbal medicine medicinal liquor for treating impotence |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145118A (en) * | 2010-11-17 | 2011-08-10 | 苏州市天灵中药饮片有限公司 | Morinda officinalis wine |
Non-Patent Citations (1)
| Title |
|---|
| "健脾益肾生精汤"治疗无精子症;徐焙;《时珍国药研究》;19920331;第3卷(第1期);第35页 * |
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