CN105663607B - Traditional Chinese medicine composition and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition and preparation method and application thereof Download PDF

Info

Publication number
CN105663607B
CN105663607B CN201610050853.5A CN201610050853A CN105663607B CN 105663607 B CN105663607 B CN 105663607B CN 201610050853 A CN201610050853 A CN 201610050853A CN 105663607 B CN105663607 B CN 105663607B
Authority
CN
China
Prior art keywords
parts
traditional chinese
chinese medicine
preparation
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201610050853.5A
Other languages
Chinese (zh)
Other versions
CN105663607A (en
Inventor
张芝庭
张涛涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUIZHOU SHENQI DRUG RESEARCH INSTITUTE
Original Assignee
GUIZHOU SHENQI DRUG RESEARCH INSTITUTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUIZHOU SHENQI DRUG RESEARCH INSTITUTE filed Critical GUIZHOU SHENQI DRUG RESEARCH INSTITUTE
Priority to CN201610050853.5A priority Critical patent/CN105663607B/en
Publication of CN105663607A publication Critical patent/CN105663607A/en
Application granted granted Critical
Publication of CN105663607B publication Critical patent/CN105663607B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/746—Morinda
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving kidney deficiency and preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from maca, ginseng, hippocampus, cordyceps sinensis, wolfberry fruit, Chinese yam, cistanche, epimedium herb, semen cuscutae, schisandra chinensis, semen allii tuberosi, poria cocos, eucommia ulmoides, achyranthes bidentata, morinda officinalis, cynomorium songaricum, astragalus membranaceus, cinnamon, raspberry, dogwood, fennel, aspongopus and liquorice.

Description

Traditional Chinese medicine composition and preparation method and application thereof
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving kidney deficiency and preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Along with the improvement of living standard of people, the dietary structure is changed greatly, high-protein and high-calorie diet and the work and life rhythm are accelerated, so that more and more people are in a sub-health state, and symptoms such as dizziness, hypomnesis, insufficient energy, dry eyes, unsmooth eyes, insomnia, night sweat, frequent urination, weak and deep pulse, weak waist and knees and the like are caused by deficiency of kidney and kidney. The published literature reports some Chinese patent medicines for improving kidney deficiency, but some Chinese medicine preparations have limitations, and many of the Chinese patent medicines are not clinically used, and the pharmacology and the drug effect are not completely clear.
Although the current commercially available hippocampi vanilla wine (Guizhou Shenqi pharmaceutical industry Co., Ltd.) has the function of improving kidney deficiency, the dosage form is single, and the wine cannot be suitable for groups with contraindication requirements on alcohol.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for improving kidney deficiency and a preparation method thereof;
the invention also aims to provide application of the pharmaceutical composition in improving kidney deficiency and kidney deficiency.
In order to achieve the aim, the invention provides a traditional Chinese medicine composition which is prepared from the following traditional Chinese medicine components in parts by weight: 15-30 parts of maca, 21-26 parts of ginseng, 20-24 parts of sea horse, 17-20 parts of cordyceps sinensis, 12-18 parts of wolfberry fruit, 10-15 parts of Chinese yam, 8-10 parts of cistanche, 8-10 parts of epimedium herb, 7-9 parts of semen cuscutae, 7-9 parts of schisandra chinensis, 5-9 parts of semen allii tuberosi, 5-7 parts of poria cocos, 4-8 parts of eucommia ulmoides, 4-6 parts of radix achyranthis bidentatae, 7-9 parts of morinda officinalis, 8-10 parts of cynomorium songaricum, 15-30 parts of astragalus membranaceus, 4-8 parts of cortex cinnamomi, 10-15 parts of raspberry, 8-10 parts of dogwood, 4-6 parts of fennel, 4-6 parts of aspongopus and 1-3 parts of liquorice.
It is preferable that: 20 parts of maca, 24 parts of ginseng, 22 parts of sea horse, 18 parts of cordyceps sinensis, 16 parts of wolfberry fruit, 12 parts of Chinese yam, 9 parts of cistanche, 9 parts of epimedium herb, 8 parts of dodder, 8 parts of schisandra chinensis, 6 parts of semen allii tuberosi, 6 parts of poria cocos, 6 parts of eucommia ulmoides, 5 parts of achyranthes bidentata, 8 parts of morinda officinalis, 9 parts of cynomorium songaricum, 18 parts of astragalus membranaceus, 6 parts of cortex cinnamomi, 12 parts of raspberry, 9 parts of dogwood, 5 parts of fennel, 5 parts of aspongopus and 2 parts of liquorice.
The invention also provides a pharmaceutical preparation for improving kidney deficiency and kidney deficiency, which is prepared from the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials, and the dosage form of the pharmaceutical preparation is a conventional dosage form in pharmaceutics.
The pharmaceutical preparation for improving kidney deficiency and kidney deficiency is preferably oral dosage form, including medicated liquor, granule, tablet, and capsule.
The preparation method of the wine comprises the step of soaking the traditional Chinese medicine components in 50-55-degree white spirit for 55-65 days, wherein the mass-volume ratio of maca to wine is 10: 1-15: 1 in g/L.
It is preferable that: also comprises a step of adding sucrose.
The preparation method of the granules comprises the following steps:
1) taking the traditional Chinese medicine components in the formula amount;
2) respectively crushing the traditional Chinese medicine components into coarse powder, mixing the obtained coarse powder, adding an ethanol solution which is 5-7 times of the weight of the traditional Chinese medicine components, heating, refluxing and extracting for 2 times, wherein each time lasts for 2.5-3 hours, combining extracting solutions, filtering, and collecting filtrate, wherein the volume fraction of the ethanol solution is 60-80%;
3) recovering ethanol, and concentrating under reduced pressure to obtain extract with relative density of 1.3-1.45 at 80 deg.C;
4) adding mannitol or dextrin, mixing, granulating, drying, and grading.
The preparation method of the tablet is to add sorbitol and sodium carboxymethyl starch to the granules based on the preparation methods 1) to 3), uniformly mix, granulate, dry, add magnesium stearate, uniformly mix and tablet to obtain the tablet.
The preparation method of the capsule is to add pregelatinized starch, dry, crush, sieve, add aerosil or magnesium stearate, mix uniformly and fill into capsules on the basis of the preparation methods 1) to 3) of the granules.
Maca: the maca contains high amounts of iron, protein, amino acid, mineral zinc, taurine and other ingredients, can obviously resist fatigue, enhance muscle endurance, resist exercise-induced fatigue, strengthen the immune system, improve the disease resistance of the body, recover and enhance energy and physical strength, and improve anemia symptoms. Various alkaloids contained in maca can regulate functions of adrenal gland, pancreas, ovary and the like, balance hormone levels in vivo, and rich taurine, protein and the like can regulate and repair physiological functions, improve qi and blood and relieve climacteric symptoms. In addition, maca can also effectively improve neurasthenia and enhance memory.
Ginseng: it can tonify primordial qi, relieve depletion, promote fluid production, and induce tranquilization. It is indicated for deficiency due to overstrain, cough, dyspnea, amnesia, vertigo, headache, impotence, frequent micturition, diabetes, metrorrhagia and metrostaxis, chronic infantile convulsion, and deficiency and fluid deficiency.
Sea horse: has effects in invigorating kidney, supporting yang, regulating qi, and promoting blood circulation. It is used to treat impotence, enuresis, dyspnea of deficiency type, dystocia, abdominal mass, furuncle, and pyogenic infections.
And (3) cordyceps sinensis: can tonify deficiency, replenish vital essence and qi, relieve cough and reduce sputum. It is indicated for dyspnea with phlegm and fluid retention, dyspnea of deficiency type, tuberculosis cough, hemoptysis, spontaneous perspiration, night sweat, impotence, spermatorrhea, soreness of waist and knees, and chronic weakness after illness.
Wolfberry fruit: has effects in nourishing kidney, moistening lung, nourishing liver, and improving eyesight. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.
Chinese yam: has effects in invigorating spleen, tonifying lung, reinforcing kidney, and replenishing vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition.
Cistanche deserticola: has the functions of invigorating kidney, benefiting essence, moistening dryness and lubricating intestine. It is used to treat impotence, female infertility, leukorrhagia, metrorrhagia, lumbago, knee pain, blood depletion, and constipation.
Herba epimedii: has the effects of invigorating kidney, supporting yang, dispelling pathogenic wind, and removing dampness. It is indicated for impotence, dribbling urination, spasm of muscles and bones, hemiplegia, weakness of waist and knees, wind-damp arthralgia, and numbness of limbs.
Dodder seed: has effects in nourishing liver and kidney, replenishing essence, and improving eyesight. It is indicated for soreness of waist and knees, seminal emission, diabetes, dribbling urine and dim eyesight.
Schisandra chinensis: it has the actions of astringing lung, nourishing kidney, promoting the production of body fluid, arresting seminal emission and arresting sweating. It is used to treat lung deficiency, asthma, cough, dry mouth, thirst, spontaneous perspiration, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea, and chronic dysentery.
Leek seeds: has effects in nourishing liver and kidney, warming waist and knee, tonifying yang, and arresting spontaneous emission. Can be used for treating sexual impotence, spermatorrhea, enuresis, frequent micturition, soreness of waist and knees, etc.
Tuckahoe, poria cocos: it has effects in eliminating dampness, promoting diuresis, invigorating spleen, regulating stomach function, calming heart, and tranquilizing mind. It is indicated for difficulty in micturition, edema, abdominal distention, expectoration, emesis, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, amnesia, etc.
Eucommia ulmoides: it has effects in nourishing liver and kidney, strengthening muscle and bone, and preventing miscarriage. It is indicated for soreness and pain of lumbar and knees, weakness of feet and knees, dribbling of urine, vaginal bleeding during pregnancy, abortion, hypertension, etc.
Achyranthes root: has effects in expelling pathogenic wind, removing dampness, dredging channels, and promoting blood circulation. It is indicated for wind-damp, soreness of waist and knees, atrophy and contracture of feet, stranguria with blood, hematuria, amenorrhea and abdominal mass. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, and traumatic injury.
Morinda officinalis: has the effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness. It is used to treat impotence, cold pain in the lower abdomen, urinary incontinence, cold uterus, arthralgia due to wind-cold-dampness, and soreness of waist and knees.
And (3) locking the positive: has effects in invigorating kidney and moistening intestine. It is indicated for impotence, hematuria, blood depletion, constipation, and weakness of waist and knees.
Astragalus root: has effects in invigorating qi, consolidating superficial resistance, expelling toxic materials, expelling pus, promoting urination, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, prolapse of nasal mucosa and nasal mucosa, chronic nephritis, albuminuria, diabetes, and unhealed wound.
The official cinnamon: has effects in invigorating primordial yang, warming spleen and stomach, removing cold accumulation, and promoting blood circulation. It is indicated for decline of vital gate fire, cold limbs and slight pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain in waist and knee, amenorrhea and abdominal mass, deep rooted carbuncle of yin type, fluid abscess, and floating yang deficiency with cold in the upper heat and cold in the lower heat.
Raspberry: has effects in nourishing liver and kidney, reducing urination, tonifying yang, stopping nocturnal emission, and improving eyesight. For impotence, seminal emission, scanty urine, enuresis, consumptive disease and dim eyesight.
Dogwood fruit: it can tonify liver and kidney, astringe essence and strengthen deficiency. It is used to treat soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder.
Fennel: it can dispel cold, alleviate pain, regulate qi and harmonize stomach. Can be used for treating cold hernia with abdominal pain, testis tenesmus, dysmenorrhea, cold pain of lower abdomen, abdominal distention and pain, anorexia, vomiting and diarrhea.
Aspongopus: has the effects of regulating qi, relieving pain, warming middle-jiao and tonifying yang. Can be used for treating stomach cold, distending pain, liver and stomach pain, kidney deficiency, sexual impotence, and soreness of waist and knees. Diaphragm stomach obstructing qi, spleen and kidney deficiency, and yang deficiency.
Licorice root: can regulate the middle warmer, relieve urgency, moisten lung, remove toxicity, and harmonize the recipe. It is indicated for weakness of spleen and stomach, poor appetite, abdominal pain, loose stool, fatigue, fever, palpitation, and toxicity of herbs and food.
The invention selects natural Chinese herbal medicines as raw materials, has no toxicity or harm to human bodies and no side effect.
The wine prepared by the invention is brownish red or reddish brown clear liquid, and has fragrant and sweet smell.
The traditional Chinese medicine composition has the health-care effects of warming and invigorating kidney yang, strengthening essence and marrow, and enhancing vitality by matching the raw materials, and can be used for treating symptoms such as kidney yang deficiency, dizziness and tinnitus, soreness and weakness of waist and knees, aversion to cold and cold limbs, mental fatigue and hypodynamia and the like. Is very beneficial to enhancing immunity, can eliminate fatigue and has great body-building value.
Detailed Description
The technical solution of the present invention is further described below, but the scope of the claimed invention is not limited to the described. The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited to the scope of the examples. These examples are intended to illustrate the invention only and are not intended to limit the scope of the invention. In addition, various modifications may occur to those skilled in the art upon reading the present disclosure, and such equivalent variations are within the scope of the present invention as defined in the appended claims.
Example 1: preparation of traditional Chinese medicine composition wine for improving kidney deficiency and kidney deficiency
Taking the following raw materials in parts by weight (g):
maca 15 ginseng 21 hippocampus 20 cordyceps 17 wolfberry 12 yam 10 cistanche 8 epimedium 8 dodder 7 schisandra 7 leek seed 5 poria 5 eucommia 4 achyranthes 4 morinda officinalis 7 cynomorium 8 astragalus 15 cinnamon 4 raspberry 10 cornus 8 fennel 4 aspongopus 4 licorice 1
Pulverizing the above Chinese medicinal materials into coarse powder, mixing, placing in a container, adding 1.5L of 50% (v/v) Maotai-flavor Chinese liquor, stirring, sealing, standing and soaking for 55 days, filtering, standing the filtrate for 72 hr, and filtering to obtain health wine for improving kidney deficiency. 20mL each time, 2 times daily
Example 2: preparation of traditional Chinese medicine composition wine for improving kidney deficiency and kidney deficiency
Taking the following raw materials in parts by weight (g):
maca 20 ginseng 24 hippocampus 22 cordyceps 18 wolfberry 16 yam 12 cistanche 9 epimedium 9 dodder 8 schisandra 8 leek seed 6 poria 6 eucommia 6 achyranthes 5 morinda 8 cynomorium 9 astragalus 18 cinnamon 6 raspberry 12 cornus 9 fennel 5 aspongopus 5 licorice 2
Pulverizing the above Chinese medicinal materials into coarse powder, mixing, placing in a container, adding 1.7L of 55% (v/v) Maotai-flavor Chinese liquor, adding 100g of sucrose, stirring, sealing, standing for soaking for 65 days, filtering, standing for 70 hr, and filtering to obtain health liquor for relieving kidney deficiency. 20mL each time, 2 times daily
Example 3: preparation of traditional Chinese medicine composition granules for improving kidney deficiency and kidney deficiency
Taking the following raw materials in parts by weight (g):
maca 30 ginseng 26 hippocampus 24 cordyceps 20 wolfberry 18 yam 15 cistanche 10 epimedium 10 dodder 9 schisandra 9 leek seed 9 poria 7 eucommia 8 achyranthes 6 morinda root 9 cynomorium 10 astragalus 30 cinnamon 8 raspberry 15 cornus 10 fennel 6 aspongopus 6 licorice 3
Respectively pulverizing the above Chinese medicinal materials into coarse powder, mixing the obtained coarse powder, adding 5 times of ethanol (volume fraction of 60%) by weight of the Chinese medicinal materials, heating and reflux-extracting for 2 times (each for 2.5 hr), mixing extractive solutions, filtering, and collecting filtrate; recovering ethanol under reduced pressure, concentrating to obtain extract with relative density of 1.3 at 80 deg.C, adding mannitol or dextrin to total amount of 5000g, mixing, granulating, drying, and grading. Specification: each bag is 5 g. The usage and dosage are as follows: it is administered orally, one bag each time, once a day.
Example 4: preparation of traditional Chinese medicine composition tablet for improving kidney deficiency and kidney deficiency
Taking the following raw materials in parts by weight (g):
maca 24 ginseng 25 hippocampus 23 cordyceps 19 wolfberry 17 yam 13 cistanche 9 epimedium 9 dodder 8 schisandra 8 leek seed 8 poria 6 eucommia 5 achyranthes 5 morinda 8 cynomorium 9 astragalus 22 cinnamon 7 raspberry 13 cornus 9 fennel 5 aspongopus 5 licorice 2
Pulverizing the above Chinese medicinal materials into coarse powder, respectively, mixing the obtained coarse powder, adding 6 times of ethanol (volume fraction of 70%) by weight of the Chinese medicinal materials, heating and reflux-extracting for 2 times, each for 3 hr, mixing extractive solutions, filtering, and collecting filtrate; recovering ethanol under reduced pressure, concentrating to obtain extract with relative density of 1.4 at 80 deg.C, adding sorbitol and sodium carboxymethyl starch (weight ratio of 1:2) to total amount of 500g, mixing, granulating, drying, adding magnesium stearate 0.5% of total amount, mixing, and tabletting to obtain 1000 tablets. Specification: 0.5 g/tablet, using and using amount: orally administered two tablets each time, once a day.
Example 5: preparation of traditional Chinese medicine composition capsule for improving kidney deficiency and kidney deficiency
Taking the following raw materials in parts by weight (g):
26 parts of maca, 23 parts of ginseng, 21 parts of sea horse, 18 parts of cordyceps sinensis, 14 parts of wolfberry fruit, 11 parts of Chinese yam, 10 parts of cistanche, 10 parts of epimedium, 10 parts of dodder, 7 parts of schisandra chinensis, 7 parts of semen allii tuberosi, 5 parts of poria cocos, 5 parts of eucommia, 4 parts of achyranthes, 7 parts of morinda officinalis, 8 parts of cynomorium songaricum, 28 parts of astragalus mongholicus, 7 parts of cassia twig, 11 parts
Respectively pulverizing the above Chinese medicinal materials into coarse powder, mixing the obtained coarse powder, adding 7 times of ethanol (volume fraction of 80%) of the weight of the Chinese medicinal materials, heating and reflux-extracting for 2 times to obtain extract with relative density of 1.45 at 80 deg.C, adding pregelatinized starch to total amount of 1000g, mixing, drying at 80 deg.C, pulverizing, sieving with 80 mesh sieve, adding 0.5% of silica gel or magnesium stearate, mixing, and filling to obtain capsule. Specification: 0.5 g/granule, using and using amount: it is administered orally 2 capsules each time, once daily.
The effect of the invention is explained in detail below with reference to clinical experimental data:
1 data and method
1.1 clinical data
Inclusion criteria were: all cases are in accordance with kidney deficiency and corresponding diseases, and are in accordance with the diagnosis of traditional Chinese medicine; the main symptoms are: soreness of the waist and knees, aversion to cold, cold limbs, hyposexuality, swollen and large tongue with white coating and deep pulse; the secondary symptoms are as follows: mental disorder, frequent nocturia, edema of lower limbs, shortness of breath, dyspnea and alopecia.
Rejection standard: (1) those with significant complications; (2) pregnant and lactating women under 18 or over 65 years of age, allergic constitution; (3) patients with heart disease, hypertension, severe heart and lung dysfunction, severe arrhythmia and psychosis are excluded; (4) if the treatment is not performed as prescribed or the curative effect cannot be judged.
300 patients were randomly selected, 207 men and 93 women, aged between 39-54 years, with an average age of 44 years. Among them, 213 cases of soreness and weakness of waist and knees, 146 cases of aversion to cold, 198 cases of hyposexuality, 227 cases of lassitude, 201 cases of insomnia and dreaminess, 82 cases of dizziness, 103 cases of amnesia, 76 cases of frequent nocturia, and 53 cases of heart function weakness. The data of the patients such as age, sex, course and the like have no significant difference (P is more than 0.05), and are comparable.
1.2 methods
The randomly selected 300 cases were divided into 6 groups, and 50 persons in each group were administered with the pharmaceutical preparations obtained in examples 1 to 5 and hippocampal herbal liquor (20 mL each time and 2 times a day, available from Guizhou Shenqi pharmaceutical products Co., Ltd.) respectively, corresponding to 1 to 6 groups. The 6 treatment courses are all one month. Patients in group 6 were discontinued taking other drugs for more than 1 week before treatment; other drugs are prohibited during the treatment period.
1.3 Observation index
The patients were counted in detail for palpitation, asthenia, sexual function, pulse image, tongue image, blood pressure, renal function and other symptoms.
Before and after administration, statistics such as palpitation, hypodynamia, sexual function, pulse image, tongue image, blood pressure and the like, and tests and records of indexes such as renal function and the like are carried out.
1.4 therapeutic criteria
The effect is shown: the indexes of liver and kidney function are obviously improved, the symptom of kidney deficiency disappears, and the disease does not relapse after the medicine is stopped for two months; the method has the following advantages: the symptoms of kidney deficiency and physical symptoms are improved; and (4) invalidation: the symptoms of kidney deficiency and body symptoms are not improved. Statistics of renal function indexes before and after administration.
1.5 statistical methods
The SPSS13.0 statistical software is used for analysis, the statistical data are tested by t inspection and X2, and when P is less than 0.05, the significant difference exists, and the statistical significance is achieved.
2 results
After six groups of patients are treated by the medicine, the traditional Chinese medicine composition for improving the kidney deficiency and the kidney deficiency has the most obvious curative effect, the condition of 94% of cases is obviously improved, the effect of the hippocampus vanilla wine for improving the kidney deficiency and the kidney deficiency is obvious, 80% of cases are improved, and the statistics is obviously different; the invention is superior to the hippocampus herb wine group in improving corresponding diseases, improving life quality and the like. The clinical effects of the six groups of health care products are shown in the table 1 and the table 2.
TABLE 1 comparison of symptom improvement after treatment in six groups of patients
Group of Number of examples Show effect Is effective Invalidation High efficiency
Group 1 50 33 12 5 90％
2 groups of 50 36 11 3 94％
Group 3 50 32 14 4 92％
4 groups of 50 31 15 4 92％
5 groups of 50 31 13 6 88％
6 groups of 50 29 11 10 80％
Note: p is less than 0.05
TABLE 2 comparison of renal function before and after treatment of six groups of patients
Figure BDA0000914875180000101
And (4) conclusion: the preparation has good effect of treating and improving kidney deficiency, kidney deficiency and corresponding diseases.
Typical cases are as follows:
chikushiji, male, 42 years old, insomnia and dreaminess, lusterless complexion, in recent years, soreness and weakness of waist and knees, dizziness and somnolence, dizziness aggravation after slight strain or activity, mental fatigue and amnesia, cicada shell on both ears, heavy feet and the like, the symptom is improved after one treatment course by taking the traditional Chinese medicine preparation for improving kidney deficiency and kidney deficiency in the embodiment 1, and the symptoms disappear and are cured after 3 treatment courses.
Li Shi, 45 years old male, with lumbago and soreness of waist for 2 years, is willing to do kneading, aggravated by strain, and more foam in urination, which is not considered because of busy work. Soreness and pain of the waist are obvious in the near two weeks, and the patients feel lack of qi and strength, weakness of leg paint, cold hands and feet and clear and long nocturia. After 2 courses of treatment of taking the medicament of the embodiment 2 of the invention, the symptoms of waist soreness, leg and knee weakness, nocturia, etc. are obviously relieved, and after one course of treatment, all symptoms are eliminated and cured.
Du Zhi, female, 48 years old, in the last three years, it is more tired and relieved when lying down, frequent urination, aggravated soreness of waist in the last two months, accompanied by nausea, dizziness, frequent micturition at night, feverish sensation in the palms and soles, dry mouth and throat, weakness of knees, restlessness and insomnia. After the preparation in the embodiment 3 of the invention is taken for 3 courses of treatment, the waist soreness is obviously relieved, other symptoms are greatly improved, and the symptoms are all eliminated and cured after the preparation is continuously taken for one course of treatment.

Claims (4)

1. The traditional Chinese medicine composition is characterized by being prepared from the following traditional Chinese medicine components in parts by weight: 15-30 parts of maca, 21-26 parts of ginseng, 20-24 parts of sea horse, 17-20 parts of cordyceps sinensis, 12-18 parts of wolfberry, 10-15 parts of Chinese yam, 8-10 parts of cistanche, 8-10 parts of epimedium herb, 7-9 parts of semen cuscutae, 7-9 parts of schisandra chinensis, 5-9 parts of semen allii tuberosi, 5-7 parts of poria cocos, 4-8 parts of eucommia ulmoides, 4-6 parts of radix achyranthis bidentatae, 7-9 parts of morinda officinalis, 8-10 parts of cynomorium songaricum, 15-30 parts of astragalus membranaceus, 4-8 parts of cortex cinnamomi, 10-15 parts of raspberry, 8-10 parts of dogwood, 4-6 parts of fennel, 4-6 parts of aspongopus and 1-3 parts of liquorice;
the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials are prepared into a pharmaceutical preparation for improving kidney deficiency and kidney deficiency, and the dosage form of the pharmaceutical preparation is a conventional dosage form in pharmaceutics;
the pharmaceutical preparation is an oral dosage form, including a wine, a granule, a tablet and a capsule;
the preparation method of the wine comprises the steps of soaking the traditional Chinese medicine components in 50-55-degree white spirit for 55-65 days, wherein the mass volume ratio of maca to the white spirit is 10: 1-15: 1 in g/L;
the preparation method of the granules comprises the following steps:
1) taking the traditional Chinese medicine components in the formula amount;
2) respectively crushing the traditional Chinese medicine components into coarse powder, mixing the obtained coarse powder, adding an ethanol solution which is 5-7 times of the weight of the traditional Chinese medicine components, heating, refluxing and extracting for 2 times, wherein each time lasts for 2.5-3 hours, combining extracting solutions, filtering, and collecting filtrate, wherein the volume fraction of the ethanol solution is 60-80%;
3) recovering ethanol, and concentrating under reduced pressure to obtain extract with relative density of 1.3-1.45 at 80 deg.C;
4) adding mannitol or dextrin, mixing, granulating, drying, and grading;
the preparation method of the tablet is based on the preparation methods 1) to 3) of the granules, adding sorbitol and sodium carboxymethyl starch, mixing uniformly, granulating, drying, adding magnesium stearate, mixing uniformly, and tabletting to obtain the tablet;
the preparation method of the capsule is based on the preparation methods 1) to 3) of the granules, adding pregelatinized starch, drying, crushing, sieving, adding aerosil or magnesium stearate, mixing uniformly, and encapsulating to obtain the capsule.
2. The traditional Chinese medicine composition according to claim 1, wherein the composition is prepared from the following traditional Chinese medicine components in parts by weight: 20 parts of maca, 24 parts of ginseng, 22 parts of sea horse, 18 parts of cordyceps sinensis, 16 parts of wolfberry fruit, 12 parts of Chinese yam, 9 parts of cistanche, 9 parts of epimedium herb, 8 parts of dodder, 8 parts of schisandra chinensis, 6 parts of semen allii tuberosi, 6 parts of poria cocos, 6 parts of eucommia ulmoides, 5 parts of achyranthes bidentata, 8 parts of morinda officinalis, 9 parts of cynomorium songaricum, 18 parts of astragalus membranaceus, 6 parts of cortex cinnamomi, 12 parts of raspberry, 9 parts of dogwood, 5 parts of fennel, 5 parts of aspongopus and 2 parts of liquorice.
3. The traditional Chinese medicine composition of claim 1, wherein the preparation method of the medicated wine further comprises the step of adding sucrose.
4. The use of the Chinese medicinal composition of claim 1 or 2 in the preparation of a medicament for improving kidney deficiency and kidney deficiency.
CN201610050853.5A 2016-01-26 2016-01-26 Traditional Chinese medicine composition and preparation method and application thereof Active CN105663607B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610050853.5A CN105663607B (en) 2016-01-26 2016-01-26 Traditional Chinese medicine composition and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610050853.5A CN105663607B (en) 2016-01-26 2016-01-26 Traditional Chinese medicine composition and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN105663607A CN105663607A (en) 2016-06-15
CN105663607B true CN105663607B (en) 2020-02-18

Family

ID=56302913

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610050853.5A Active CN105663607B (en) 2016-01-26 2016-01-26 Traditional Chinese medicine composition and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN105663607B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106039035A (en) * 2016-08-05 2016-10-26 杨贵林 Traditional Chinese medicine composition for fully boosting immunity of human body
CN106511781A (en) * 2016-12-19 2017-03-22 四川科宇实业有限公司 Water-paste pills
WO2020024132A1 (en) * 2018-08-01 2020-02-06 姚红军 Health care pillow
CN108853245B (en) * 2018-08-01 2021-08-17 中国中医科学院中药研究所 Traditional Chinese medicine composition for treating perimenopausal syndrome and preparation method and application thereof
CN109567183A (en) * 2018-11-20 2019-04-05 广州正当年保健品科技有限公司 A kind of strengthening yang and invigorating kidney composition
CN109846031A (en) * 2018-12-18 2019-06-07 武汉悟真堂养生科技发展有限公司 Food compositions, food and preparation method thereof and instructions of taking

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN104689012A (en) * 2015-03-24 2015-06-10 李光亮 Kidney reinforcing and bone strengthening wine and making method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN104689012A (en) * 2015-03-24 2015-06-10 李光亮 Kidney reinforcing and bone strengthening wine and making method thereof

Also Published As

Publication number Publication date
CN105663607A (en) 2016-06-15

Similar Documents

Publication Publication Date Title
CN105663607B (en) Traditional Chinese medicine composition and preparation method and application thereof
CN102210844B (en) Chinese medicinal composition for treating chronic hepatitis and preparation method thereof
CN104922543A (en) Medicine composite for treating amenorrhea and preparation method thereof
CN104984297A (en) Application of pharmaceutical composition in preparation of drugs for treating amenorrhea
CN104208418A (en) Rosa laevigata michx health oral solution for securing essence, reducing urination and tonifying kidneys and preparation method thereof
CN102671178B (en) Preparation method of Chinese medicinal composition for treating nephrotic syndrome and uremia and application thereof
CN104208540A (en) Compound traditional Chinese medicine for treating gastric cancer and preparation method thereof
CN103127326A (en) Pharmaceutical composition for treating osteoarthritis and preparation method thereof
CN101961458A (en) Oral medicament for treating osteonecrosis of femoral head
CN101698076A (en) Traditional Chinese preparation for tonifying kidney and Yang
CN104524071A (en) Pharmaceutical composition for treating primary renal disease and application thereof
CN105943651A (en) Traditional Chinese medicine composition for treating premature ovarian failure, and application thereof
CN1977936A (en) Chinese medicine compound preparation for treating male-female deficiency syndrome and its preparing method
CN102274417A (en) Chinese patent medicament for treating aplastic anemia
CN102078559A (en) Chinese medicinal composition with functions of tonifying kidney and strengthening brain
CN104547523A (en) Medicine for enhancing immunity and preparation method thereof
CN101491612B (en) Medicine for treating mammary hyperplasia and early breast cancer
CN109876127B (en) Blood-nourishing angelica sinensis capsule and preparation method thereof
CN103330837A (en) Traditional Chinese medicine composition for curing osteoporosis of menopausal women
CN113398223A (en) Traditional Chinese medicine composition, powder and pill for treating infertility and preparation method and application thereof
CN112717084A (en) Traditional Chinese medicine composition for treating hyperprolactinemia, preparation method and application
CN106581299B (en) Traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof
CN104398662A (en) Traditional Chinese medicine preparation treating femur head necrosis and preparation technology thereof
CN104306534A (en) Traditional Chinese medicine medicated wine capable of nourishing kidney and tonifying yang and preparation method thereof
CN111329927B (en) Traditional Chinese medicine for treating female idiopathic edema

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant