CN105833300A

CN105833300A - Gastrointestinal B-ultrasonic traditional Chinese medicine co-imaging agent and preparation method thereof

Info

Publication number: CN105833300A
Application number: CN201610172872.5A
Authority: CN
Inventors: 不公告发明人
Original assignee: Xue Yaohong
Current assignee: Xue Yaohong
Priority date: 2016-03-24
Filing date: 2016-03-24
Publication date: 2016-08-10

Abstract

A gastrointestinal B-ultrasonic traditional Chinese medicine co-imaging agent includes the following raw material medicines: polyalthia nemoralis, thesium chinensis, veronicastrum herb, achyranthes bidentata, potentilla fulgens, herba ecliptae, radix rubus buergeri, hydrocotyle chinensis, finger citron flower, loofah sponge, cynanchum mooreanum, cherry leaves, agrimonia pilosa, pinellia ternata, oberonia iridifolia, asiatic cudweed, shorthairy antenoron herb, common adenostema herb, zanthoxylum dimorphophyllum, poria cocos, dicranopteris ampla, thlaspi arvense, concha arcae, round-leaved mint leaves, lindernia ruellioides, curcuma zedoary, sculellaria barbata, fructus akebiae, rose flowers, lindera aggregata leaves, semen raphani, fructus malvae vertillatae, sterculia nobilis and kapok. The co-imaging agent is low in cost, is convenient to use, is safe, is free of toxic and side effects and can improve excellent image ratio and inspection accuracy. With the imaging additive, more gastrointestinal diseases can be inspected through B-ultrasonic. The invention provides a powerful evidence for clinical diagnosis. The co-imaging agent is simple and practical in preparation process.

Description

A kind of gastrointestinal B-ultrasonic Chinese medicine contrast agent and preparation method thereof

Technical field

The invention belongs to pharmaceutical technology field, relate to a kind of Chinese medicine composition, be specifically related to a kind of gastrointestinal B Super with Chinese medicine contrast agent and preparation method thereof.

Background technology

Ultrasonic image diagnosis is one of important diagnostic method in medical science.Material is had three to act on greatly by ultrasound wave: One is mechanism, owing to ultrasonic energy is huge, often makes material particle make altofrequency mechanical vibration, Thus produce smash, condense, agitation effects.Two is warm-heat effect, ul-trasonic irradiation when material, its Energy is absorbed by material, thus makes mass temperature raise phenomenon.Three is cavitation, ul-trasonic irradiation Time on liquid, in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure great variety And become sparse, the most around under the effect of fluid molecule pulling force, form a little cavity, be sky Change effect.This cavity time of staying is the longest, collapses again, due to cavity shape under huge acoustic pressure effect Become and disappear, produce a large amount of bubble will affect ultrasonic diagnosis effect, so, elimination bubble is ultrasonic to help shadow The Main Function of agent.

At present, the clinical diagnosis of a lot of gastrointestinal disease relies primarily on x-ray Barium meal examination and gastroscopy, Such as gastric ulcer and duodenal ulcer etc., but these two check all have certain damage and misery, have one Fixed limitation, is difficult to universal inspection, and especially children's, anemia of pregnant woman, elderly and infirm is not easily accepted by, another nothing Symptom is not easy to accept, and causes some sing misdiagnosis and mistreatment, even occurs that Alimentary Tract Perforation or massive hemorrhage just come Diagnosis and treatment, have delayed therapic opportunity.Although ultrasound diagnosis has simplicity, safety, hurtless measure, no pain etc. Advantage, but owing to it is poor to the diagnostic accuracy of part gastrointestinal disease, always cannot be by more gastrointestinal disease Sick employing.

For B ultrasonic gastrointestinal contrast agent, prior art describes by Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20% The contrast agent that 100 mesh fine powders are mixed with, has convergence, an antacid effect to gastrointestinal disease, but deficiency Place is to produce strong echo luminous point deficiency after patient takes contrast agent, and reflecting effect is the best, and coat of the stomach level shows Unintelligible；After patient takes this contrast agent, gastric acid strong reaction, there are pain and sense of discomfort, are unfavorable for stomach The ultrasonic contrast of intestinal, can not apply this contrast agent to gastrorrhagia patient.To this end, be bursting to develop more peace Entirely it is effectively used for the Chinese medicine gastrointestinal contrast agent of B ultrasonic.

Summary of the invention

It is an object of the invention to provide a kind of gastrointestinal B-ultrasonic Chinese medicine contrast agent and preparation method thereof, the method The gastrointestinal B-ultrasonic Chinese medicine contrast agent of preparation is easy to use, have no side effect and can improve the standard of ultrasound diagnosis Really property.

For achieving the above object, present invention employs techniques below scheme:

A kind of gastrointestinal B-ultrasonic Chinese medicine contrast agent, the crude drug of described gastrointestinal B-ultrasonic Chinese medicine contrast agent is by casting skin Root, Herba Thesii, Herba veronicastri villosuli, Radix Achyranthis Bidentatae, Folium potentillae velutinae (Radix Potentillae Fulgentis), Herba Ecliptae, Radix rubi buergeri, Herba Hydrocotylis Chinensis, Flos Citri Sarcodactylis, Retinervus Luffae Fructus, Radix Tylophorae arenicolae, Folium Pruni pseudocerasi, Herba Agrimoniae, the Rhizoma Pinelliae, Herba Oberoniae iridifoliae, Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), wind Gas grass, Radix Zanthoxyli Spinifolii, Poria, Dicranopteris amplachinget Chiu, Xi, Concha Arcae, Radix Menthae Rotundifoliae, Lindernia ruellioides (Colsm.) Pennell, Rhizoma Curcumae, half Branch lotus, Fructus Akebiae, Flos Rosae Rugosae, Folium Linderae strychnifoliae, Semen Raphani, Fructus Malvae, Semen Sterculiae Nobilis, Flos Bombacis Malabarici composition.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 9-15 part, Herba Thesii 3-6 part, Herba veronicastri villosuli 8-13 part, Radix Achyranthis Bidentatae 3-5 part, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1-3 part, ink Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 5-10 part, Radix rubi buergeri 3-6 part, Herba Hydrocotylis Chinensis 8-13 part, Flos Citri Sarcodactylis 3-5 part, Retinervus Luffae Fructus 11-15 part, Radix Tylophorae arenicolae 5-10 part, Folium Pruni pseudocerasi 2-5 part, Herba Agrimoniae 4-9 part, Rhizoma Pinelliae 12-20 part, Herba Oberoniae iridifoliae 10-16 part, Herba Gnaphalii Hypoleuci 3-8 part, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5-12 part, Herba Adenostemmatis 12-17 part, Radix Zanthoxyli Spinifolii 7-12 part, Poria 4-9 part, Dicranopteris amplachinget Chiu 15-20 part, Xi 10-15 part, Concha Arcae 8-12 part, Radix Menthae Rotundifoliae 2-5 part, Lindernia ruellioides (Colsm.) Pennell 3-7 part, Rhizoma Curcumae 11-14 part, Herba Scutellariae Barbatae 5-10 part, Fructus Akebiae 13-16 part, Flos Rosae Rugosae 3-10 part, Folium Linderae strychnifoliae 8-13 Part, Semen Raphani 3-5 part, Fructus Malvae 1-3 part, Semen Sterculiae Nobilis 5-10 part, Flos Bombacis Malabarici 9-15 part.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 9 parts, Herba Thesii 6 parts, Herba veronicastri villosuli 8 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 15 parts, Radix Tylophorae arenicolae 5 parts, Folium Pruni pseudocerasi 3 Part, Herba Agrimoniae 5 parts, the Rhizoma Pinelliae 12 parts, Herba Oberoniae iridifoliae 16 parts, 3 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 12 parts, pathogenic wind Grass 12 parts, Radix Zanthoxyli Spinifolii 10 parts, 9 parts of Poria, Dicranopteris amplachinget Chiu 15 parts, Xi 15 parts, Concha Arcae 8 parts, with sweet and sour flavor Root 5 parts, Lindernia ruellioides (Colsm.) Pennell 3 parts, Rhizoma Curcumae 14 parts, Herba Scutellariae Barbatae 5 parts, Fructus Akebiae 16 parts, Flos Rosae Rugosae 10 parts, crow 8 parts of medicine leaf, Semen Raphani 5 parts, Fructus Malvae 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 15 parts.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 15 parts, Herba Thesii 3 parts, Herba veronicastri villosuli 13 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 5 parts, Radix rubi buergeri 4 parts, Herba Hydrocotylis Chinensis 10 parts, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 13 parts, Radix Tylophorae arenicolae 6 parts, Folium Pruni pseudocerasi 4 Part, Herba Agrimoniae 8 parts, the Rhizoma Pinelliae 20 parts, Herba Oberoniae iridifoliae 10 parts, 8 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 parts, pathogenic wind Grass 17 parts, Radix Zanthoxyli Spinifolii 12 parts, 4 parts of Poria, Dicranopteris amplachinget Chiu 20 parts, Xi 10 parts, Concha Arcae 12 parts, fish Cus-cus 2 parts, Lindernia ruellioides (Colsm.) Pennell 7 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 10 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 3 parts, Folium Linderae strychnifoliae 13 parts, Semen Raphani 3 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 5 parts, Flos Bombacis Malabarici 9 parts.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 13 parts, Herba Thesii 4 parts, Herba veronicastri villosuli 9 parts, Radix Achyranthis Bidentatae 4 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 2 parts, Herba Ecliptae 6 parts, Radix rubi buergeri 5 parts, Herba Hydrocotylis Chinensis 12 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 9 parts, Folium Pruni pseudocerasi 4 Part, Herba Agrimoniae 7 parts, the Rhizoma Pinelliae 13 parts, Herba Oberoniae iridifoliae 11 parts, 4 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, pathogenic wind Grass 13 parts, Radix Zanthoxyli Spinifolii 7 parts, 5 parts of Poria, Dicranopteris amplachinget Chiu 18 parts, Xi 11 parts, Concha Arcae 9 parts, with sweet and sour flavor Root 4 parts, Lindernia ruellioides (Colsm.) Pennell 6 parts, Rhizoma Curcumae 12 parts, Herba Scutellariae Barbatae 6 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 5 parts, crow 10 parts of medicine leaf, Semen Raphani 4 parts, Fructus Malvae 2 parts, Semen Sterculiae Nobilis 6 parts, Flos Bombacis Malabarici 10 parts.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 14 parts, Herba Thesii 5 parts, Herba veronicastri villosuli 12 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 4 parts, Herba Hydrocotylis Chinensis 11 parts, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 14 parts, Radix Tylophorae arenicolae 8 parts, Folium Pruni pseudocerasi 3 Part, Herba Agrimoniae 6 parts, the Rhizoma Pinelliae 17 parts, Herba Oberoniae iridifoliae 15 parts, 7 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, pathogenic wind Grass 16 parts, Radix Zanthoxyli Spinifolii 8 parts, 8 parts of Poria, Dicranopteris amplachinget Chiu 16 parts, Xi 14 parts, Concha Arcae 11 parts, with sweet and sour flavor Root 3 parts, Lindernia ruellioides (Colsm.) Pennell 5 parts, Rhizoma Curcumae 13 parts, Herba Scutellariae Barbatae 9 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 7 parts, crow 11 parts of medicine leaf, Semen Raphani 3 parts, Fructus Malvae 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 12 parts.

Further, make described gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 11 parts, Herba Thesii 5 parts, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 8 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 9 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 7 parts, Folium Pruni pseudocerasi 5 Part, Herba Agrimoniae 9 parts, the Rhizoma Pinelliae 15 parts, Herba Oberoniae iridifoliae 12 parts, 5 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 9 parts, pathogenic wind Grass 15 parts, Radix Zanthoxyli Spinifolii 9 parts, 7 parts of Poria, Dicranopteris amplachinget Chiu 19 parts, Xi 13 parts, Concha Arcae 10 parts, with sweet and sour flavor Root 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 9 parts, crow 12 parts of medicine leaf, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 13 parts.

Further, Polyalthia nemoralis A. D C. 11 parts, Herba Thesii 5 parts, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 Part, Herba Ecliptae 8 parts, Radix rubi buergeri 3 parts, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 15 parts, old monarch Palpus 7 parts, Folium Pruni pseudocerasi 2 parts, Herba Agrimoniae 4 parts, the Rhizoma Pinelliae 19 parts, Herba Oberoniae iridifoliae 14 parts, 6 parts of Herba Gnaphalii Hypoleuci, gold Line grass 7 parts, Herba Adenostemmatis 14 parts, Radix Zanthoxyli Spinifolii 9 parts, 6 parts of Poria, Dicranopteris amplachinget Chiu 17 parts, Xi 13 parts, watt Stupefied sub 10 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 4 parts, Folium Linderae strychnifoliae 9 parts, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 14 parts.

Further, described gastrointestinal B-ultrasonic Chinese medicine contrast agent is prepared in following manner:

(1) by the Herba Thesii of described components by weight percent, Folium Pruni pseudocerasi, the Rhizoma Pinelliae, Herba Oberoniae iridifoliae, Radix Zanthoxyli Spinifolii, celestial being Crane grass, Flos Rosae Rugosae, Poria, Herba veronicastri villosuli, Lindernia ruellioides (Colsm.) Pennell, Folium potentillae velutinae (Radix Potentillae Fulgentis), Folium Linderae strychnifoliae, Herba Gnaphalii Hypoleuci, gold thread After grass, Herba Adenostemmatis, Fructus Malvae, Flos Bombacis Malabarici mixing, pulverizing pulverizer, medicated powder fineness is 40-60 Mesh；

(2) medicated powder addition step (1) prepared relative to the determining alcohol of medicated powder quality 4-6 times amount is Soaking 1.5-2.5 hour in the ethanol of 90%-95%, heating extraction 2 times, backflow 2.5-3 hour, takes every time Clear liquid, united extraction liquid, 150-200 mesh filters, obtains the first extracting solution；Filter the medicinal residues obtained to add Relative to the ethanol that determining alcohol is 85%-90% of described medicinal residues quality 2-3 times, it is heated to reflux 2 hours, carries Take, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes Alcohol solvent, is dried, it is thus achieved that dry cream, makes 80 mesh fine powders after pulverizing；

(3) after being mixed by other raw medicinal material remaining of described components by weight percent, pulverizer powder is carried out Broken, medicated powder fineness is 300-500 mesh；

(4) medicated powder boiling step (3) prepared twice, adds water for the first time as medical material weight 8-10 times amount, decocts 1-1.5h, and add water 6-8 times amount into medical material weight for the second time, decocts 1-1.2h, merges Decocting liquid, being evaporated to relative density when 65 DEG C at 0.07MPa, 65-70 DEG C is 1.10-1.12, adds pure and strong Degree makes alcohol content reach volume ratio 85% for the ethanol of 90%-95%, stirring, stands 24-28 hour, and filtrate subtracts Push back receipts ethanol concentrating, filtrate 0.07MPa, under the conditions of 65 DEG C concentrating under reduced pressure when becoming to 65 DEG C relative Density is 1.30-1.35, obtains traditional Chinese medicine thick paste；

(5) thick paste step (4) obtained is dried, pulverizes and makes 80 mesh fine powders；

(6) the fine powder mixing obtained in step (2), (5), stirs, and obtains medicated powder combination Thing；

(7) by step (6) prepare medicated powder compositions conventional method make tablet, granule, powder, The pharmaceutical dosage form such as capsule or oral liquid.

The gastrointestinal B-ultrasonic of present invention Chinese medicine contrast agent low cost, easy to use, safe has no side effect, energy Enough improve excellent development ratio, improve and check accuracy, enable more gastrointestinal disease to be entered by B ultrasonic Row checks, provides strong foundation for clinical diagnosis, and preparation technology is simple, practical.

Detailed description of the invention:

For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with enforcement Technical scheme is clearly and completely described by example.Obviously, described embodiment is this A part for invention rather than whole embodiments.Based on described embodiments of the invention, ability The every other embodiment that territory those of ordinary skill is obtained on the premise of without creative work, all belongs to In the scope of protection of the invention.

The invention provides a kind of gastrointestinal B-ultrasonic Chinese medicine contrast agent, described Chinese medicine contrast agent includes following Raw medicinal material: Polyalthia nemoralis A. D C., Herba Thesii, Herba veronicastri villosuli, Radix Achyranthis Bidentatae, Folium potentillae velutinae (Radix Potentillae Fulgentis), Herba Ecliptae, Radix rubi buergeri, big Copper coin dish, Flos Citri Sarcodactylis, Retinervus Luffae Fructus, Radix Tylophorae arenicolae, Folium Pruni pseudocerasi, Herba Agrimoniae, the Rhizoma Pinelliae, Herba Oberoniae iridifoliae, the sky and water Ant grass, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Herba Adenostemmatis, Radix Zanthoxyli Spinifolii, Poria, Dicranopteris amplachinget Chiu, Xi, Concha Arcae, Radix Menthae Rotundifoliae, Lindernia ruellioides (Colsm.) Pennell, Rhizoma Curcumae, Herba Scutellariae Barbatae, Fructus Akebiae, Flos Rosae Rugosae, Folium Linderae strychnifoliae, Semen Raphani, Fructus Malvae, phoenix eyes Really, Flos Bombacis Malabarici.

The pharmacology of various raw medicinal materials is as follows:

Polyalthia nemoralis A. D C.: sweet is flat.Return spleen, stomach, kidney channel.Invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence.Control chronic gastritis, Taste lose, inappetence, myasthenia of limbs, seminal emission.

Herba Thesii: nature and flavor: pungent；Micro-hardship；Cold in nature.Gui Jing: return spleen；Kidney channel.Function with cure mainly: heat clearing away, Dampness removing, removing toxic substances.Main anemopyretic cold, heatstroke, lung abscess, tonsillitis；Tuberculous lymphadenitis, mastalgia, furuncle and phyma, Stranguria, yellow cellulitis, lumbago, seminal emission.

Herba veronicastri villosuli, Classification system Veronicastrum stenostachyum (Hemsl.) Yamazaki, for profound The raw Herba veronicastri villosuli of ginseng section plant axil or the stem and leaf of Herba veronicastri villosuli or root.Inducing diuresis to remove edema, dissipating blood stasis detoxifies.For ascites, Edema, dysuria, menoxenia, amenorrhea, traumatic injury；Parotitis, furuncle, burn and scald are controlled in external Wound, venom.

Radix Achyranthis Bidentatae: source: medical material Ji Yuan: for the root of amaranthaceous plant Radix Achyranthis Bidentatae.Latin plant animal mineral name: Achyranthes bidentata Bl.Nature and flavor: bitter；Acid；Property flat.Gui Jing: liver；Kidney channel.Function cures mainly: Invigorating the liver and kidney；Bone and muscle strengthening；Promoting blood circulation to restore menstrual flow；Ignite descending；Inducing diuresis for treating stranguria syndrome.Main soreness of waist and knee joint；Flaccidity and weakness of the lower limbs； Amenorrhea due to stagnation of blood；Dysmenorrhea；Puerperal abdominal pain due to blood stasis；Levy abdominal mass；Retention of placenta；Pyretic stranguria；Stranguria with blood；Traumatic injury； Carbuncle malignant boil；Laryngopharynx swelling and pain.

Folium potentillae velutinae (Radix Potentillae Fulgentis): source: medical material Ji Yuan: for the root of rosaceous plant velutinous cinquefoil.Latin plant Animal mineral name: Potentilla griffithii Hook.f.var.velutina Card.Nature and flavor: puckery；Micro-hardship； Flat.Gui Jing: stomach, liver, large intestine channel.Function cures mainly: circulation of qi promoting helps digestion, astringing to arrest bleeding, heat clearing and blood circulation promoting. The long-pending stomachache of staple food, gastric and duodenal ulcers, infantile malnutrition, dysentery, puerperal hemorrhage is too much, and children's shies Wind, facial paralysis.

Herba Ecliptae, sweet in the mouth, acid, cool in nature, return liver, kidney channel, liver and kidney tonifying；Cooling blood for hemostasis.Main Liver and kidney Not enough；Have a dizzy spell；Early whitening of beard and hair；Spit blood；Spitting of blood；Epistaxis；Have blood in stool；Dysentery；Collapse；Leakage；Outward Hinder hemorrhage.

Radix rubi buergeri: acid is flat.Return liver, kidney channel.Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Treat for stomachache acid regurgitation, yellow Subcutaneous ulcer hepatitis, vomits and diarrhoea, leucorrhea, hemorrhoid." practical Chinese herbal medicine ": convergence, removing toxic substances, pain relieving.Treat for stomachache, Hyperchlorhydria, seminal emission, headache.

Herba Hydrocotylis Chinensis: source: medical material Ji Yuan: for the herb of samphire Herba Hydrocotylis Chinensis.Nature and flavor: Acrid in the mouth；Micro-hardship；Property flat.Function cures mainly: regulating QI to relieve pain；Eliminating damp, detoxifying.Main abdominal pain；Hepatitis；Yellow Subcutaneous ulcer；Dysuria；Eczema.

Flos Citri Sarcodactylis: nature and flavor: micro-hardship；Tepor.Gui Jing: enter liver；Stomach warp.Function cures mainly: depressed liver-energy dispersing and QI regulating； Stomach function regulating soon every.Main stomachache due to hyperactive liver-QI attacking the stomach；Inappetence.

Retinervus Luffae Fructus: source: medical material Ji Yuan: for cucurbitaceous plant Fructus Luffae or the dimension pipe of Fructus Luffae mature fruit difficult to understand Bundle.Nature and flavor: bitter in the mouth；Cool in nature.Gui Jing: return lung；Liver；Stomach warp.Function cures mainly: dredge the meridian passage；Solve Poison detumescence.Main pain in chest and hypochondrium；Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, the cough of lung gesture, carbuncle future Sore, his carbuncle.

Radix Tylophorae arenicolae: source: medical material Ji Yuan: the root disappeared for the plant bamboo spirit of trailing plants section or aerial parts.Nature and flavor: Bitter in the mouth；Micro-pungent；Property flat.Gui Jing: lung meridian.Function cures mainly: clearing away heat and cooling blood；Function of gallbladder promoting；Removing toxic substances.Main the moon Shoot without hitting the target heat；Asthenia chronic cough；Spitting of blood；Distending pain over the hypochondrium；Vomiting and nausea；Dysentery；Puerperal fidgets due to deficiency；Scrofula；Unknown Toxic swelling；Snakeworm；Mad dog is bitten.

Folium Pruni pseudocerasi: source: medical material Ji Yuan: for the leaf of rosaceous plant Fructus Pruni pseudocerasi.Nature and flavor: sweetness and bitterness；Temperature； Nontoxic.Gui Jing: liver；Spleen；Lung meridian.Function cures mainly: warming middle-JIAO and strengthening the spleen, and cough-relieving is stopped blooding, and detoxify parasite killing. Main cold syndrome of the stomach food stagnation；Diarrhoea；Cough；Spit blood；Skin infection swells carbuncle；Snake bite and insect sting, trichomonas vaginitis.

Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is put down, and GUIXIN, Liver Channel have Astringing to arrest bleeding, effect of dysentery relieving parasite killing, cure mainly various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, Metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off the cards such as power, carbuncle, traumatic injury, wound hemorrhage.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, wind Expectorant dizziness, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.

Herba Oberoniae iridifoliae: source: medical material Ji Yuan: for the herb that orchid Rhizoma Iridis Tectori is blue.Nature and flavor: micro-hardship；Property Cool.Gui Jing: bladder warp.Function cures mainly: clearing away heat-damp and promoting diuresis；Promoting blood circulation to remove obstruction in the collateral.Main urinary tract infection；Bronchus Scorching；Asthma；Enteritis；Dyspepsia；Traumatic injury；Fracture.

Herba Gnaphalii Hypoleuci: sweet, bitter, flat.Return lung, Liver Channel.Dispel the wind, dispersing lung-QI and dissipating phlegm, solve noxious dampness.Cure the wound Wind is caught a cold, cough with copious phlegm, asthma, eczema, ulcer of the lower limb.Soviet Union doctor " Chinese herbal medicine handbook ": lung moistening Expectorant, relieving cough and asthma, blood pressure lowering.Cure cold cough, chronic bronchitis, asthma, hypertension, and stomach is burst Infections；And control dysmenorrhea, traumatic injury, skin ulceration, eczema, bones and muscles pain due to rheumatism.

Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): source: for the herb of polygonaceae plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).Summer, autumn gather, using fresh herb or dry. Nature and flavor: pungent, temperature.Function cures mainly: expelling wind and removing dampness, regulating QI to relieve pain, hemostasis, dissipating blood stasis.Dispelling the wind and dampness pathogens osteodynia, Stomachache, hemoptysis, spit blood, have blood in stool, metrorrhagia, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury.

Herba Adenostemmatis: source: medical material Ji Yuan: for the herb of feverfew adenostemma laveniaKuntze.Latin plant animal ore deposit Name: Adenostemma lauenia (L.) O.Kuntze.Nature and flavor: acrid in the mouth；Micro-hardship；Property frightened.Function master Control: heat-clearing and toxic substances removing；Expelling wind and removing dampness.Main cold, fever；Icterohepatitis；Cough due to lung-heat；Laryngopharynx swelling and pain； Beriberoid pyretic arthralgia；Acute mastitis；Carbuncle furuncle；Venom.

Radix Zanthoxyli Spinifolii: source: Rutaceae xanthoxylum Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, is used as medicine with root, root bark and fruit. The whole year adopts root；Spring and summer fruit picking.Nature and flavor: root: pungent, temperature.Function cures mainly: root: expelling wind and cold.For Rheumatic numbness, cough due to wind and cold；Traumatic injury is controlled in external.Root bark: regulating QI to relieve pain.For peratodynia, abdomen Bitterly.Really: synthetism granulation promoting, alleviating pain and detumescence.For traumatic injury, waist and leg ache.

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For Edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.

Dicranopteris amplachinget Chiu: call big plumage Dicranopteris dichotoma.Medical material Ji Yuan: for tender Seedling and the medulla of Diplopterygium glaucum (Thunb ex Houtt) Nakai section plant Dicranopteris amplachinget Chiu. Nature and flavor are micro-sweet, flat, puckery.Return Liver Channel.Function cures mainly: removing toxic substances；Hemostasis.Main centipete bite；Epistaxis； Traumatic hemorrhage.

Xi: source: medical material Ji Yuan: for the herb of crucifer Xi.Latin plant animal ore deposit Name: Thlaspi arvense L.Nature and flavor: bitter；Sweet；It is slightly cold.Gui Jing: liver；Kidney channel.Function cures mainly: Heat-clearing and toxic substances removing, inducing diuresis to remove edema.Main conjunctival congestion and swelling pain；Lung abscess；Acute appendicitis；Have loose bowels；Dysentery；Leucorrhea；Puerperal Abdominal pain due to blood stasis；Dyspepsia；Oedema due to nephritis；Cirrhotic ascites；Ulcerative carbuncle toxic swelling.

Concha Arcae: nature and flavor: salty is flat.Gui Jing: return lung, stomach, Liver Channel.Effect: expectorant blood stasis dispelling, Hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, Stomachache pantothenic acid.

Radix Menthae Rotundifoliae: source: medical material Ji Yuan: for the root of labiate roundleaf Herba Menthae Rotundifoliae.Nature and flavor: acrid in the mouth； Cool in nature.Function cures mainly: regulating QI to relieve pain；Heat-clearing and toxic substances removing.Main gastral cavity side of body distending pain；Hernia；Red-white dysentery.

Lindernia ruellioides (Colsm.) Pennell: another name Herba Linderniae ruellioidis, Radix Euonymi japonici, small size tiger tongue Huang, tiger tongue Herba pteridis vittatae, field jasmine, Lower tea, Testudinis medicine, saw sickle grass, Tian Suxiang, Herba Linderniae anagallis, snake melon is fragrant, spend son in vain, double end town, 80 scarce, Alpine yarrow, Herba sagittariae pygmaeae Huang, earrings grass.Source: medical material Ji Yuan: for the herb of goatweed Lindernia ruellioides (Colsm.) Pennell. Nature and flavor: sweet in the mouth；Light；Property flat.Function cures mainly: vital energy regualting and blood circulation-promoting；Removing toxic substances and promoting subsidence of swelling.Main menoxenia；Bitterly Warp；Amenorrhea；Stomachache；Acute mastitis；Scrofula；Traumatic injury；Serpentis lyssodexis.

Rhizoma Curcumae: nature and flavor: acrid, bitter, warm；Gui Jing: return liver, spleen channel.Function: circulation of qi promoting removing blood stasis, removing food stagnancy Pain relieving.For abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain；Early cervical carcinoma.

Herba Scutellariae Barbatae: source: medical material Ji Yuan: for the herb of labiate Herba Scutellariae Barbatae.Nature and flavor: acrid in the mouth； Bitter；Cold in nature.Gui Jing: return lung；Liver；Kidney channel.Function cures mainly: heat-clearing and toxic substances removing；Dissipating blood stasis stops blooding；Diuresis Detumescence.Main pyretic toxicity carbuncle；Have sore throat；Lung abscess；Acute appendicitis；Scrofula；Venom；Traumatic injury； Spit blood；Epistaxis；Stranguria with blood；Edema；Ascites and cancer.

Fructus Akebiae: the wooden ratan of plants of Lardizabalaceae threeleaf akebia Akebia tri foliata (Thunb.) Koidz.. Bitter in the mouth, cold in nature；Return liver, spleen channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, Gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, costalgia, hernia, dysmenorrhea, uterus tenesmus.

Flos Rosae Rugosae: source: medical material Ji Yuan: for rosaceous plant Flos Rosae Rugosae and the flower of polyphyll Flos Rosae Rugosae.Nature and flavor: Sweet；Micro-hardship；Temperature；Nontoxic.Gui Jing: liver；Spleen channel.Function cures mainly: resolving depression of regulating the flow of vital energy；Regulating menstruation by adjusting the flow of blood. Chest and diaphragm caused by main depression of liver-QI is full vexed, gastral cavity side of body distending pain, and breast is made swollen, menoxenia, and dysentery is had loose bowels, Leukorrhagia, traumatic injury carbuncle.

Folium Linderae strychnifoliae: another name burdock dustpan tea.Source: medical material Ji Yuan: for the leaf of the canella Radix Linderae.Nature and flavor: Pungent；Temperature.Gui Jing: spleen；Kidney channel.Function cures mainly: warming middle-JIAO is regulated the flow of vital energy；Reducing swelling and alleviating pain.Main coldness and pain in the epigastrium； Frequent micturition；Rheumatic arthralgia；Traumatic pain；Scald.

Semen Raphani: nature and flavor: pungent, sweet, flat.Gui Jing: enter spleen, stomach, lung, large intestine channel.Function cures mainly: Dyspepsia and intestinal stasis relieving, lowering the adverse-rising QI to resolve phlegm.Curing mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, diarrhoea, dysentery is thick and heavy, and cough is many Expectorant, QI rising in reverse order dyspnea with fullness of the chest.

Fructus Malvae: another name Semen Abutili.Source: this strain Mongols conventional crude drugs, for Malvaceae plant winter The dry mature fruit of certain herbaceous plants with big flowers Malva verticillata L..Gather when summer, autumn two season fruit maturation, remove miscellaneous Matter, dries in the shade.Nature and flavor: sweet, puckery are cool.Function cures mainly: clearing away heat and promoting diuresis, detumescence.For urine retention, water Swollen, thirsty；Urinary tract infection.

Semen Sterculiae Nobilis: sweet is flat.Return stomach, large intestine, small intestine meridian.Stomach function regulating helps digestion, and detoxify parasite killing.Main regurgitation of food from the stomach Tell food, abdominal pain due to worm stagnation, colic, children's's rotten head infections.

Flos Bombacis Malabarici: nature and flavor: sweet；Light；Cool in nature.Gui Jing: spleen；Liver；Large intestine channel.Function cures mainly: clear Heat；Dampness removing；Removing toxic substances；Hemostasis.Master has loose bowels；Dysentery；Hemoptysis；Spit blood；Metrorrhagia；Incised wound is hemorrhage；Skin ulcer Poison；Eczema.

Wherein, in described gastrointestinal B-ultrasonic Chinese medicine contrast agent, the ratio of weight and number of various raw medicinal materials is preferably: Polyalthia nemoralis A. D C. 9-15 part, Herba Thesii 3-6 part, Herba veronicastri villosuli 8-13 part, Radix Achyranthis Bidentatae 3-5 part, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1-3 part, ink Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 5-10 part, Radix rubi buergeri 3-6 part, Herba Hydrocotylis Chinensis 8-13 part, Flos Citri Sarcodactylis 3-5 part, Retinervus Luffae Fructus 11-15 part, Radix Tylophorae arenicolae 5-10 part, Folium Pruni pseudocerasi 2-5 part, Herba Agrimoniae 4-9 part, Rhizoma Pinelliae 12-20 part, Herba Oberoniae iridifoliae 10-16 part, Herba Gnaphalii Hypoleuci 3-8 part, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5-12 part, Herba Adenostemmatis 12-17 part, Radix Zanthoxyli Spinifolii 7-12 part, Poria 4-9 part, Dicranopteris amplachinget Chiu 15-20 part, Xi 10-15 part, Concha Arcae 8-12 part, Radix Menthae Rotundifoliae 2-5 part, Lindernia ruellioides (Colsm.) Pennell 3-7 part, Rhizoma Curcumae 11-14 part, Herba Scutellariae Barbatae 5-10 part, Fructus Akebiae 13-16 part, Flos Rosae Rugosae 3-10 part, Folium Linderae strychnifoliae 8-13 Part, Semen Raphani 3-5 part, Fructus Malvae 1-3 part, Semen Sterculiae Nobilis 5-10 part, Flos Bombacis Malabarici 9-15 part.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 9 parts, Herba Thesii 6 parts, Herba veronicastri villosuli 8 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 15 parts, Radix Tylophorae arenicolae 5 parts, Folium Pruni pseudocerasi 3 parts, Herba Agrimoniae 5 parts, the Rhizoma Pinelliae 12 parts, Herba Oberoniae iridifoliae 16 parts, 3 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 12 parts, Herba Adenostemmatis 12 parts, Radix Zanthoxyli Spinifolii 10 parts, Poria 9 Part, Dicranopteris amplachinget Chiu 15 parts, Xi 15 parts, Concha Arcae 8 parts, Radix Menthae Rotundifoliae 5 parts, Lindernia ruellioides (Colsm.) Pennell 3 parts, Rhizoma Curcumae 14 Part, Herba Scutellariae Barbatae 5 parts, Fructus Akebiae 16 parts, Flos Rosae Rugosae 10 parts, Folium Linderae strychnifoliae 8 parts, Semen Raphani 5 parts, Semen Abutili Really 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 15 parts.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 15 parts, Herba Thesii 3 Part, Herba veronicastri villosuli 13 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 5 parts, Radix rubi buergeri 4 parts, Herba Hydrocotylis Chinensis 10 parts, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 13 parts, Radix Tylophorae arenicolae 6 parts, Folium Pruni pseudocerasi 4 parts, Herba Agrimoniae 8 parts, the Rhizoma Pinelliae 20 parts, Herba Oberoniae iridifoliae 10 parts, 8 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 parts, Herba Adenostemmatis 17 parts, Radix Zanthoxyli Spinifolii 12 parts, 4 parts of Poria, Dicranopteris amplachinget Chiu 20 parts, Xi 10 parts, Concha Arcae 12 parts, Radix Menthae Rotundifoliae 2 parts, Lindernia ruellioides (Colsm.) Pennell 7 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 10 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 3 parts, Folium Linderae strychnifoliae 13 parts, Semen Raphani 3 Part, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 5 parts, Flos Bombacis Malabarici 9 parts.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 13 parts, Herba Thesii 4 Part, Herba veronicastri villosuli 9 parts, Radix Achyranthis Bidentatae 4 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 2 parts, Herba Ecliptae 6 parts, Radix rubi buergeri 5 parts, Herba Hydrocotylis Chinensis 12 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 9 parts, Folium Pruni pseudocerasi 4 parts, Herba Agrimoniae 7 parts, the Rhizoma Pinelliae 13 parts, Herba Oberoniae iridifoliae 11 parts, 4 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, Herba Adenostemmatis 13 parts, Radix Zanthoxyli Spinifolii 7 parts, 5 parts of Poria, Dicranopteris amplachinget Chiu 18 parts, Xi 11 parts, Concha Arcae 9 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 6 parts, cowherb Art 12 parts, Herba Scutellariae Barbatae 6 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 5 parts, Folium Linderae strychnifoliae 10 parts, Semen Raphani 4 parts, Fructus Malvae 2 parts, Semen Sterculiae Nobilis 6 parts, Flos Bombacis Malabarici 10 parts.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 14 parts, Herba Thesii 5 Part, Herba veronicastri villosuli 12 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 4 parts, big copper coin Dish 11 parts, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 14 parts, Radix Tylophorae arenicolae 8 parts, Folium Pruni pseudocerasi 3 parts, Herba Agrimoniae 6 parts, half Summer 17 parts, Herba Oberoniae iridifoliae 15 parts, 7 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, Herba Adenostemmatis 16 parts, Radix Zanthoxyli Spinifolii 8 parts, 8 parts of Poria, Dicranopteris amplachinget Chiu 16 parts, Xi 14 parts, Concha Arcae 11 parts, Radix Menthae Rotundifoliae 3 parts, Lindernia ruellioides (Colsm.) Pennell 5 parts, Rhizoma Curcumae 13 parts, Herba Scutellariae Barbatae 9 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 7 parts, Folium Linderae strychnifoliae 11 parts, Semen Raphani 3 parts, Fructus Malvae 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 12 parts.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 11 parts, Herba Thesii 5 Part, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 8 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 9 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 7 parts, Folium Pruni pseudocerasi 5 parts, Herba Agrimoniae 9 parts, the Rhizoma Pinelliae 15 parts, Herba Oberoniae iridifoliae 12 parts, 5 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 9 parts, Herba Adenostemmatis 15 parts, Radix Zanthoxyli Spinifolii 9 parts, 7 parts of Poria, Dicranopteris amplachinget Chiu 19 parts, Xi 13 parts, Concha Arcae 10 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 9 parts, Folium Linderae strychnifoliae 12 parts, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 13 parts.

It is further preferred that the ratio of weight and number of various raw medicinal materials is: Polyalthia nemoralis A. D C. 11 parts, Herba Thesii 5 Part, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 8 parts, Radix rubi buergeri 3 parts, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 15 parts, Radix Tylophorae arenicolae 7 parts, Folium Pruni pseudocerasi 2 parts, Herba Agrimoniae 4 parts, the Rhizoma Pinelliae 19 parts, Herba Oberoniae iridifoliae 14 parts, 6 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 7 parts, Herba Adenostemmatis 14 parts, Radix Zanthoxyli Spinifolii 9 parts, 6 parts of Poria, Dicranopteris amplachinget Chiu 17 parts, Xi 13 parts, Concha Arcae 10 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 4 parts, Folium Linderae strychnifoliae 9 parts, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 14 parts.

Described gastrointestinal B-ultrasonic Chinese medicine contrast agent can be prepared in following manner:

Toxicity test:

Acute toxicity test: the tablet dissolved prepared with the present invention is in distilled water, with clinical consumption per day 70 times, 120 times, 170 times and 250 times give 4 groups of white mice (often group 15) feeding dispensing respectively, observe 10 days；The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, not See toxic reaction.White mouse oral cavity and damaged skin are carried out irritation test, there are no irritative response and Other untoward reaction.

Long term toxicity test: the tablet present invention prepared is dissolved by 9.57,19.83 and 41.97g crude drugs/kg In water, to 3 groups of mices (often group 20) continuous use 16 weeks respectively, every day 2 times, and drug withdrawal 4 weeks After, result shows: Chinese medicine of the present invention to the hair of 3 groups of test mices, behavior, defecation, body weight, The indexs such as organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not have Being found difference change and histological indications shows, after medication 16 weeks and drug withdrawal 4 weeks, mice is each dirty Device is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also do not have after drug withdrawal Difference reaction, application safety.

The medicine of the present invention impact on mice with constipation Small intestine advance activity:

Animal, medicine, reagent: animal: healthy ICR mice 60, male and female half and half, weight 20-22g.This Invention tablet, R-1132, phenolphthalein tablets (phenolphthalein sugar-tablet), breathe out medicine pharmaceutical factory and produce.

Experimentation: take ICR mice 60, with R-1132 50m/kg gavage modeling, continuous 10 My god, period normal diet, form Constipation Model, be randomly divided into 6 groups, often group 10, male and female half and half, Being divided into normal group, model group, positive drug group (gives phenolphthalein tablets), soft capsule of the present invention high, medium and low three Individual dosage group, is administered ibid, successive administration 14 days, and before experiment, water 12h is can't help in fasting, after last is administered 2h, gavages with the charcoal end arabic gum suspension lml/g that volume fraction is 5% respectively, puts to death each after 20min Group mice, cut open the belly every Mus small intestinal charcoal end displacement of measurement and total small intestinal length, it is converted into charcoal end and moves Distance accounts for the percentage rate of total small intestinal length, t test and judge group difference, the results are shown in Table 1.

The impact (n=10) on mice with constipation Small intestine advance activity of the table 1 each medicine

Group	Dosage	Propelling rate (%)
			Normal group	0	64.41±5.67
Model group	0	27.11±7.34
			Positive drug group	0.3g/kg	38.45±8.76*
High dose group of the present invention	20g crude drug/kg	57.54±12.43**##
			Dosage group in the present invention	10g crude drug/kg	39.85±7.12*#
Low dose group of the present invention	5g crude drug/kg	42.75±6.75*

Compare with model group, * * P < 0.01*P < 0.05, compare with positive drug group, ##P < 0.01#P < 0.05

Illustrate that the gastric peristalsis of Chinese medicinal tablet of the present invention is the most hyperfunction, compare with blank group, it is possible to substantially Promote gastrointestinal motility function.

Clinical data:

Case selection: take 189 examples because gastrointestinal upset needs to carry out B ultrasonic or gastroscopic is in hospital or outpatient service is suffered from Person, male 94 examples, female 95 example, age 22-65 year.

Test method: after requiring patient to check evening before that day 10, water is prohibited in fasting, checks the morning. First carry out ultrasound diagnosis, carry out gastroscopy the most again and carry out confirming and compareing.

Ultrasound diagnosis method: 3, the tablet of the oral present invention, then drinks 200-300ml warm water, drinks Within latter 2-5 minute, check.Check position: based on horizontal position and right arm reclining, be aided with left lateral position and Semireclining position；Operational approach: by Stomach duodenum at the body surface projection of abdominal part, successively from the bottom of cardia, stomach Portion, body of stomach stomach size are curved, gastric angle, gastric antrum pylorus pipe and duodenum do continuous whole scanning, Make every effort to clearly show Stomach duodenum ultrasonogram overall picture, primary part observation stomach cardia, lesser gastric curvature, stomach angle, Stomach pyloric canal and pyloric cap；Examine each position of stomach, wall of stomach thickness, hierarchical structure, wriggling And the imaging characteristic of lesion region, gastric mucosa continued integrity etc..

Inspection result: ultrasound diagnosis and gastroscopy result control case, is shown in Table 2.

Table 2B is super to be checked and gastroscopy result control case: (example)

Knowable to upper table ultrasound diagnosis and gastroscopic result compare, after taking Tablets, B ultrasonic is examined The accuracy rate looked into can be up to 97.89%, is greatly improved the scope of application and the success rate of ultrasound diagnosis.

After taking the Chinese medicine contrast agent of the present invention, situation of developing, it is shown in Table 3.

Development criterion:

Excellent: developer is full good, bubble-free and mucus interference in coat of the stomach, gastric mucosa face shows clearly, Coat of the stomach five-layer structure is clear and legible.

General: developer is full good, there are a small amount of bubble and mucus interference in coat of the stomach, mucosal surface shows relatively Clearly, coat of the stomach five-layer structure is still clear, but does not affect detection.

Bad: to have a large amount of bubble and mucus in gastral cavity, mucosal surface shows unclear, and coat of the stomach level is beyond recognition, Impact detection.

Table 3 develop situation statistics as follows:

Number of cases	Excellent	Typically	Bad
				189	182 (96.3%)	7 (3.7%)	0 (0%)

Model case:

Case 1:

River, man, 61 years old, people from Lixia District, Jinan City, in JIUYUE, 2014 was gone to a doctor.Patient is because starting abdominal part Distending pain, after cause again backache, come here and go to a doctor, through 3, the tablet of the oral present invention, after 5 minutes, Carry out ultrasound diagnosis, B ultrasonic diagnostic result: gastric wall mucus echo is crude, is diagnosed as superficial gastritis.

Case 2:

Lee, female, 59 years old, people from Lixia District, Jinan City, goes to a doctor in April, 2014.Patient because of epigastric discomfort, Glutted, the most obvious, also have simultaneously and feel sick, belch, weak and constipation, lean body mass, comes me Place is medical, the powder 15g of the present invention that takes after mixing it with water, and after 8 minutes, stomach ultrasound diagnosis is done in vertical position, finds patient Stomach lower edge is less than interiliac line 5.1CM, and diagnosis patient is gastroptosis.

Case 3:

Week certain, man, 53 years old, people from Linzhou City, Zibo, in March, 2015 go to a doctor.Patient because of epigastrium pain, Belch, acid regurgitation, Nausea and vomiting, examine, 3, the tablet of oral administration embodiment of the present invention l, 10 minutes After, ordinary ultrasonography b screen shows, duodenectasis deforms, interior for opaque dark area of fluid, and can visit and Chyme echo luminous point, the intestinal tube wall of limitation expansion is smooth, and without substantially protuberance, clarify a diagnosis this patient for this Suffers from duodenitis.

Last it is noted that above example is only in order to illustrate technical scheme, rather than to it Limit；Although the present invention being described in detail with reference to previous embodiment, the ordinary skill of this area Personnel it is understood that the technical scheme described in foregoing embodiments still can be modified by it, or Person carries out equivalent to wherein portion of techniques feature；And these amendments or replacement, do not make corresponding skill The essence of art scheme departs from the scope of various embodiments of the present invention technical scheme.

Claims

1. a gastrointestinal B-ultrasonic Chinese medicine contrast agent, it is characterised in that: described gastrointestinal B-ultrasonic Chinese medicine contrast agent Crude drug by Polyalthia nemoralis A. D C., Herba Thesii, Herba veronicastri villosuli, Radix Achyranthis Bidentatae, Folium potentillae velutinae (Radix Potentillae Fulgentis), Herba Ecliptae, Radix rubi buergeri, big Copper coin dish, Flos Citri Sarcodactylis, Retinervus Luffae Fructus, Radix Tylophorae arenicolae, Folium Pruni pseudocerasi, Herba Agrimoniae, the Rhizoma Pinelliae, Herba Oberoniae iridifoliae, the sky and water Ant grass, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Herba Adenostemmatis, Radix Zanthoxyli Spinifolii, Poria, Dicranopteris amplachinget Chiu, Xi, Concha Arcae, Radix Menthae Rotundifoliae, Lindernia ruellioides (Colsm.) Pennell, Rhizoma Curcumae, Herba Scutellariae Barbatae, Fructus Akebiae, Flos Rosae Rugosae, Folium Linderae strychnifoliae, Semen Raphani, Fructus Malvae, phoenix eyes Really, Flos Bombacis Malabarici composition.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 1, it is characterised in that: make institute State gastrointestinal B-ultrasonic Chinese medicine contrast agent crude drug composition and parts by weight be: Polyalthia nemoralis A. D C. 9-15 part, Herba Thesii 3-6 part, Herba veronicastri villosuli 8-13 part, Radix Achyranthis Bidentatae 3-5 part, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1-3 part, Herba Ecliptae 5-10 part, Radix rubi buergeri 3-6 Part, Herba Hydrocotylis Chinensis 8-13 part, Flos Citri Sarcodactylis 3-5 part, Retinervus Luffae Fructus 11-15 part, Radix Tylophorae arenicolae 5-10 part, Folium Pruni pseudocerasi 2-5 part, Herba Agrimoniae 4-9 part, Rhizoma Pinelliae 12-20 part, Herba Oberoniae iridifoliae 10-16 part, Herba Gnaphalii Hypoleuci 3-8 part, gold thread Grass 5-12 part, Herba Adenostemmatis 12-17 part, Radix Zanthoxyli Spinifolii 7-12 part, Poria 4-9 part, Dicranopteris amplachinget Chiu 15-20 part, Xi 10-15 part, Concha Arcae 8-12 part, Radix Menthae Rotundifoliae 2-5 part, Lindernia ruellioides (Colsm.) Pennell 3-7 part, Rhizoma Curcumae 11-14 part, half Branch lotus 5-10 part, Fructus Akebiae 13-16 part, Flos Rosae Rugosae 3-10 part, Folium Linderae strychnifoliae 8-13 part, Semen Raphani 3-5 part, Fructus Malvae 1-3 part, Semen Sterculiae Nobilis 5-10 part, Flos Bombacis Malabarici 9-15 part.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: make described The crude drug of gastrointestinal B-ultrasonic Chinese medicine contrast agent forms and parts by weight are: Polyalthia nemoralis A. D C. 9 parts, Herba Thesii 6 parts, Herba veronicastri villosuli 8 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 15 parts, Radix Tylophorae arenicolae 5 parts, Folium Pruni pseudocerasi 3 parts, Herba Agrimoniae 5 parts, the Rhizoma Pinelliae 12 parts, Herba Oberoniae iridifoliae 16 parts, 3 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 12 parts, Herba Adenostemmatis 12 parts, Radix Zanthoxyli Spinifolii 10 parts, Poria 9 Part, Dicranopteris amplachinget Chiu 15 parts, Xi 15 parts, Concha Arcae 8 parts, Radix Menthae Rotundifoliae 5 parts, Lindernia ruellioides (Colsm.) Pennell 3 parts, Rhizoma Curcumae 14 Part, Herba Scutellariae Barbatae 5 parts, Fructus Akebiae 16 parts, Flos Rosae Rugosae 10 parts, Folium Linderae strychnifoliae 8 parts, Semen Raphani 5 parts, Semen Abutili Really 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 15 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: make described The crude drug of gastrointestinal B-ultrasonic Chinese medicine contrast agent forms and parts by weight are: Polyalthia nemoralis A. D C. 15 parts, Herba Thesii 3 parts, Herba veronicastri villosuli 13 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 5 parts, Radix rubi buergeri 4 parts, Herba Hydrocotylis Chinensis 10 parts, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 13 parts, Radix Tylophorae arenicolae 6 parts, Folium Pruni pseudocerasi 4 parts, Herba Agrimoniae 8 parts, the Rhizoma Pinelliae 20 parts, Herba Oberoniae iridifoliae 10 parts, 8 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 parts, Herba Adenostemmatis 17 parts, Radix Zanthoxyli Spinifolii 12 parts, Poria 4 Part, Dicranopteris amplachinget Chiu 20 parts, Xi 10 parts, Concha Arcae 12 parts, Radix Menthae Rotundifoliae 2 parts, Lindernia ruellioides (Colsm.) Pennell 7 parts, Rhizoma Curcumae 11 Part, Herba Scutellariae Barbatae 10 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 3 parts, Folium Linderae strychnifoliae 13 parts, Semen Raphani 3 parts, the winter Certain herbaceous plants with big flowers fruit 3 parts, Semen Sterculiae Nobilis 5 parts, Flos Bombacis Malabarici 9 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: make described The crude drug of gastrointestinal B-ultrasonic Chinese medicine contrast agent forms and parts by weight are: Polyalthia nemoralis A. D C. 13 parts, Herba Thesii 4 parts, Herba veronicastri villosuli 9 parts, Radix Achyranthis Bidentatae 4 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 2 parts, Herba Ecliptae 6 parts, Radix rubi buergeri 5 parts, Herba Hydrocotylis Chinensis 12 parts, Flos Citri Sarcodactylis 3 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 9 parts, Folium Pruni pseudocerasi 4 parts, Herba Agrimoniae 7 parts, the Rhizoma Pinelliae 13 parts, Herba Oberoniae iridifoliae 11 parts, 4 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, Herba Adenostemmatis 13 parts, Radix Zanthoxyli Spinifolii 7 parts, 5 parts of Poria, Dicranopteris amplachinget Chiu 18 parts, Xi 11 parts, Concha Arcae 9 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 6 parts, Rhizoma Curcumae 12 parts, half 6 parts of lotus of branch, Fructus Akebiae 14 parts, Flos Rosae Rugosae 5 parts, Folium Linderae strychnifoliae 10 parts, Semen Raphani 4 parts, Fructus Malvae 2 parts, Semen Sterculiae Nobilis 6 parts, Flos Bombacis Malabarici 10 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: make described The crude drug of gastrointestinal B-ultrasonic Chinese medicine contrast agent forms and parts by weight are: Polyalthia nemoralis A. D C. 14 parts, Herba Thesii 5 parts, Herba veronicastri villosuli 12 parts, Radix Achyranthis Bidentatae 3 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 1 part, Herba Ecliptae 10 parts, Radix rubi buergeri 4 parts, Herba Hydrocotylis Chinensis 11 Part, Flos Citri Sarcodactylis 4 parts, Retinervus Luffae Fructus 14 parts, Radix Tylophorae arenicolae 8 parts, Folium Pruni pseudocerasi 3 parts, Herba Agrimoniae 6 parts, the Rhizoma Pinelliae 17 Part, Herba Oberoniae iridifoliae 15 parts, 7 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 11 parts, Herba Adenostemmatis 16 parts, Radix Zanthoxyli Spinifolii 8 parts, Fu Siberian cocklebur 8 parts, Dicranopteris amplachinget Chiu 16 parts, Xi 14 parts, Concha Arcae 11 parts, Radix Menthae Rotundifoliae 3 parts, Lindernia ruellioides (Colsm.) Pennell 5 parts, cowherb Art 13 parts, Herba Scutellariae Barbatae 9 parts, Fructus Akebiae 13 parts, Flos Rosae Rugosae 7 parts, Folium Linderae strychnifoliae 11 parts, Semen Raphani 3 parts, Fructus Malvae 1 part, Semen Sterculiae Nobilis 10 parts, Flos Bombacis Malabarici 12 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: make described The crude drug of gastrointestinal B-ultrasonic Chinese medicine contrast agent forms and parts by weight are: Polyalthia nemoralis A. D C. 11 parts, Herba Thesii 5 parts, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 8 parts, Radix rubi buergeri 6 parts, Herba Hydrocotylis Chinensis 9 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 12 parts, Radix Tylophorae arenicolae 7 parts, Folium Pruni pseudocerasi 5 parts, Herba Agrimoniae 9 parts, the Rhizoma Pinelliae 15 parts, Herba Oberoniae iridifoliae 12 parts, 5 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 9 parts, Herba Adenostemmatis 15 parts, Radix Zanthoxyli Spinifolii 9 parts, 7 parts of Poria, Dicranopteris amplachinget Chiu 19 parts, Xi 13 parts, Concha Arcae 10 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 9 parts, Folium Linderae strychnifoliae 12 parts, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 13 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: Polyalthia nemoralis A. D C. 11 Part, Herba Thesii 5 parts, Herba veronicastri villosuli 10 parts, Radix Achyranthis Bidentatae 5 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 3 parts, Herba Ecliptae 8 parts, Radix rubi buergeri 3 Part, Herba Hydrocotylis Chinensis 8 parts, Flos Citri Sarcodactylis 5 parts, Retinervus Luffae Fructus 15 parts, Radix Tylophorae arenicolae 7 parts, Folium Pruni pseudocerasi 2 parts, red crowned crane Grass 4 parts, the Rhizoma Pinelliae 19 parts, Herba Oberoniae iridifoliae 14 parts, 6 parts of Herba Gnaphalii Hypoleuci, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 7 parts, Herba Adenostemmatis 14 parts, Radix Zanthoxyli Spinifolii 9 parts, 6 parts of Poria, Dicranopteris amplachinget Chiu 17 parts, Xi 13 parts, Concha Arcae 10 parts, Radix Menthae Rotundifoliae 4 parts, Lindernia ruellioides (Colsm.) Pennell 4 parts, Rhizoma Curcumae 11 parts, Herba Scutellariae Barbatae 8 parts, Fructus Akebiae 14 parts, Flos Rosae Rugosae 4 parts, Folium Linderae strychnifoliae 9 parts, Semen Raphani 5 parts, Fructus Malvae 3 parts, Semen Sterculiae Nobilis 8 parts, Flos Bombacis Malabarici 14 parts.

Gastrointestinal B-ultrasonic Chinese medicine contrast agent the most according to claim 2, it is characterised in that: described gastrointestinal B ultrasonic Chinese medicine contrast agent is prepared in following manner: