CN106963953A - A kind of B ultrasound Chinese medicine assistant - Google Patents
A kind of B ultrasound Chinese medicine assistant Download PDFInfo
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- CN106963953A CN106963953A CN201710145138.4A CN201710145138A CN106963953A CN 106963953 A CN106963953 A CN 106963953A CN 201710145138 A CN201710145138 A CN 201710145138A CN 106963953 A CN106963953 A CN 106963953A
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- A61K49/00—Preparations for testing in vivo
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Abstract
A kind of B ultrasound Chinese medicine assistant, be made the Chinese medicine assistant raw material composition and parts by weight be：8 13 parts of cape jasmine, 35 parts of aloe, 13 parts of rhizoma atractylodis, 5 10 parts of dandelion, 5 10 parts of myrrh, 13 16 parts of cortex albiziae, 3 10 parts of Dicranopteris amplachinget Chiu, 8 13 parts of pseudo-ginseng, 35 parts of rascal, 13 parts of dentiferous dendropanax root and stem, 5 10 parts of Radix zanthoxyli, 9 15 parts of common bombax flower, 37 parts of curcuma zedoary, 34 parts of eupatorium, fragrant 58 parts of structure, 12 15 parts of the bark of official magnolia, 10 16 parts of luffa, 38 parts of blood clam, 5 12 parts of Fructus Malvae Vertillatae, 12 17 parts of cinnamomum japonicum, 46 parts of Basil, 8 12 parts of the coptis, 34 parts of radix scutellariae, 12 15 parts of Sculellaria barbata, 59 parts of Asian puccoon, 7 12 parts of evodia rutaecarpa, 49 parts of the tuber of pinellia, 15 20 parts of dried orange peel, 10 15 parts of Poria cocos.
Description
Technical field
The invention belongs to pharmaceutical technology field, it is related to a kind of Chinese medicine composition, and in particular to a kind of B ultrasound helps shadow with Chinese medicine
Agent.
Background technology
Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasonic wave has three big effects to material：One is machinery
Effect, because ultrasonic energy is huge, often makes material particle make high-frequency mechanical oscillation, thus produces and smash, condense, stirring
Effect.Two be warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature rise existing
As.Three be cavitation, when ul-trasonic irradiation is on liquid, the weak region (if any microscopic bubble etc.) of liquid internal stress by
Become sparse in acoustic pressure great variety, at this moment under surrounding liquid molecule pulling force effect, form a small cavity, be sky
Change is acted on.This cavity residence time is not long, is collapsed again under the effect of huge acoustic pressure, because cavity formation is with disappearing, produces
A large amount of bubbles will influence Ultrasonic Diagnosis effect, so, eliminate the main function that bubble is ultrasonic assistant.
At present, the clinical diagnosis of many gastrointestinal diseases relies primarily on x-ray Barium meal examination and gastrocopy, such as stomach is burst
Ulcer and duodenal ulcer etc., but this two inspections have certain damage and pain, have some limitations, and are difficult popularization and examine
Look into, especially children, pregnant woman, elderly and infirm are not easily accepted by, another asymptomatic person is not easy to receive, and causes some sing misdiagnosis and mistreatments, very
To there is Alimentary Tract Perforation or massive haemorrhage just carrys out diagnosis and treatment, therapic opportunity is delayed.Although ultrasound diagnosis has easy, safe, noninvasive
The advantages of wound, no pain, but because it is poor to the diagnostic accuracy of part gastrointestinal disease, always can not be by more gastrointestinal diseases
Using.
For B ultrasound stomach and intestine assistant, prior art describes the 100 mesh fine powders by cuttlebone fine powder 80% and the bletilla striata 20%
The assistant being mixed with, to gastrointestinal disease have convergence, only acid effect, but weak point be patient take after assistant produce
Strong echo luminous point is not enough, and reflecting effect is not good, and coat of the stomach level shows unintelligible；Patient is taken after this assistant, and stomach acid reaction is strong
It is strong, there are pain and sense of discomfort, be unfavorable for the ultrasonic contrast of stomach and intestine, this assistant can not be applied to gastrorrhagia patient.Therefore, being bursting to
Develop more Chinese medicine stomach and intestine assistants safely and effectively for B ultrasound.
The content of the invention
Above-mentioned weak point based on prior art, the invention provides a kind of B ultrasound Chinese medicine assistant, the Chinese medicine helps shadow
Agent is easy to use, safe to have no toxic side effect.
The above-mentioned purpose of the present invention is realized by following technical proposals：
A kind of B ultrasound Chinese medicine assistant, be made the Chinese medicine assistant raw material composition and parts by weight be：Cape jasmine 8-13
Part, 3-5 parts of aloe, 1-3 parts of rhizoma atractylodis, 5-10 parts of dandelion, 5-10 parts of myrrh, 13-16 parts of cortex albiziae, 3-10 parts of Dicranopteris amplachinget Chiu, three
Seven 8-13 parts, 3-5 parts of rascal, 1-3 parts of dentiferous dendropanax root and stem, 5-10 parts of Radix zanthoxyli, 9-15 parts of common bombax flower, 3-7 parts of curcuma zedoary, 3-4 parts of eupatorium,
Fragrant structure 5-8 parts, 12-15 parts of the bark of official magnolia, 10-16 parts of luffa, 3-8 parts of blood clam, 5-12 parts of Fructus Malvae Vertillatae, 12-17 parts of cinnamomum japonicum, nine
4-6 parts of tower of layer, 8-12 parts of the coptis, 3-4 parts of radix scutellariae, 12-15 parts of Sculellaria barbata, 5-9 parts of Asian puccoon, 7-12 parts of evodia rutaecarpa, tuber of pinellia 4-9
Part, 15-20 parts of dried orange peel, 10-15 parts of Poria cocos.
Further, be made the Chinese medicine assistant raw material composition and parts by weight be：8 parts of cape jasmine, 5 parts of aloe is grey
1 part of art, 10 parts of dandelion, 5 parts of myrrh, 16 parts of cortex albiziae, 10 parts of Dicranopteris amplachinget Chiu, 8 parts of pseudo-ginseng, 5 parts of rascal, 1 part of dentiferous dendropanax root and stem, two sides
10 parts of pin, 15 parts of common bombax flower, 3 parts of curcuma zedoary, 3 parts of eupatorium, fragrant 5 parts of structure, 12 parts of the bark of official magnolia, 16 parts of luffa, 3 parts of blood clam, winter certain herbaceous plants with big flowers
Really 12 parts, 12 parts of cinnamomum japonicum, 6 parts of Basil, 8 parts of the coptis, 3 parts of radix scutellariae, 15 parts of Sculellaria barbata, 5 parts of Asian puccoon, 10 parts of evodia rutaecarpa, half
9 parts of summer, 15 parts of dried orange peel, 15 parts of Poria cocos.
Further, be made the Chinese medicine assistant raw material composition and parts by weight be：13 parts of cape jasmine, 3 parts of aloe is grey
3 parts of art, 5 parts of dandelion, 10 parts of myrrh, 13 parts of cortex albiziae, 3 parts of Dicranopteris amplachinget Chiu, 13 parts of pseudo-ginseng, 3 parts of rascal, 3 parts of dentiferous dendropanax root and stem, two sides
5 parts of pin, 9 parts of common bombax flower, 7 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 8 parts of structure, 15 parts of the bark of official magnolia, 10 parts of luffa, 8 parts of blood clam, Fructus Malvae Vertillatae 5
Part, 17 parts of cinnamomum japonicum, 4 parts of Basil, 10 parts of the coptis, 4 parts of radix scutellariae, 13 parts of Sculellaria barbata, 6 parts of Asian puccoon, 12 parts of evodia rutaecarpa, the tuber of pinellia 4
Part, 20 parts of dried orange peel, 10 parts of Poria cocos.
Further, be made the Chinese medicine assistant raw material composition and parts by weight be：9 parts of cape jasmine, 4 parts of aloe is grey
2 parts of art, 6 parts of dandelion, 6 parts of myrrh, 14 parts of cortex albiziae, 5 parts of Dicranopteris amplachinget Chiu, 10 parts of pseudo-ginseng, 4 parts of rascal, 2 parts of dentiferous dendropanax root and stem, two sides
6 parts of pin, 10 parts of common bombax flower, 5 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 7 parts of structure, 13 parts of the bark of official magnolia, 11 parts of luffa, 4 parts of blood clam, Fructus Malvae Vertillatae
6 parts, 13 parts of cinnamomum japonicum, 5 parts of Basil, 12 parts of the coptis, 3 parts of radix scutellariae, 12 parts of Sculellaria barbata, 9 parts of Asian puccoon, 7 parts of evodia rutaecarpa, the tuber of pinellia 5
Part, 18 parts of dried orange peel, 11 parts of Poria cocos.
Further, the Chinese medicine assistant is prepared in following manner：
(1) each medicinal material of the components by weight percent is taken, 10-12 times of water of dosing material gross weight, after immersion 45-75 minutes,
Decoct 1 time, decocting time 3-3.5 hours, after filtration, 8-10 times of water of dosing material gross weight is decocted the 2nd time, decocting time
2.5-3 hours, after filtration, 6-8 times of water of dosing material gross weight was decocted the 3rd time, decocting time 2-2.5 hours, after filtration,
Merge 3 filtrates, the filtration of 120 mesh, it is 1.12~1.15 that filtrate, which is heated and is concentrated into relative density at 60 DEG C, obtains concentrate, sprays
Dry, 80~85 DEG C of 170~175 DEG C of EAT, the leaving air temp of spray dryer is then ground into powder, 80 mesh are made
Fine powder；
(2) 80 mesh fine powders made from step (1) are added into appropriate auxiliary material and granule, capsule, tablet is made.
B ultrasound provided by the present invention Chinese medicine assistant, it gives full play to each component using common Chinese herbal medicine as raw material
The property of medicine：
Its cold in nature, bitter of cape jasmine, function is with curing mainly：Purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body,《Sheng Nong's herbal classic》：
" cure mainly perverse trend in five, white leprosy, red leprosy, sore ....”
Aloe：It is bitter, cold.Return liver, large intestine channel.Under rushing down, clear liver, desinsection.For constipation with heat retention；Irascibility is had a headache；Hot eyes infantile convulsion；
Abdominal pain due to enterositosis；Mange；Hemorrhoid complicated by anal fistula；Solve crotons poison.
Rhizoma atractylodis：Pungent, hardship, it is warm-natured.Returns spleen, stomach, Liver Channel.It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For damp retention in middle-jiao, gastral cavity
Distention and fullness in the abdomen, diarrhea, oedema, tinea pedis impotence is knitted, and arthralgia pain due to rheumatism, anemofrigid cold, yctalopia, eyes dusk is puckery.
Dandelion：For feverfew dandelion Taraxacum mongolicum Hand.-Mazz., alkali ground dandelion
Taraxacum sinicum Kitag. or the drying herb for belonging to several plants together.It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.
For furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Myrrh：Also known as myrrh, it is olive subject plant Chinese violet tree or Ha Didingshu dry resin.Main product is in African rope horse
In, the ground such as Ethiopia and India.The white oleo-gum-resin oozed out by bark crack is gathered, becomes reddish brown in air
Color and hard nahlock.After smashing, fry to coke black application.Cure mainly chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, abdominal mass, traumatic injury, carbuncle
Swollen sore, acute appendicitis, red eye, swell pain.The effects such as having promoting blood circulation and stopping pain, detumescence and promoting granulation.It is a kind of promoting blood circulation, stagnation resolvation in east, analgesic, is good for
The Chinese medicine of stomach, from place of production ancient times Arab and the band of East Africa one.《Northern history》In it is i.e. on the books, say be come from Western Regions mortise state.In west
Side, it is said that myrrh is a kind of medicine for having a magical curative effect.Hebrew by myrrh branch be fabricated to various aromatic, preservative and
Anodyne.In Old Testament period, often it is made into ointment, is applied to wound, promotes wound healing.
Cortex albiziae：It is sweet, it is mild-natured.There are resolving stagnation for tranquilization, effect of activating blood circulation and reducing swelling, for confused and worried, Xie Yu insomnias, lung carbuncle
Sore swells, the pain of injury caused by falling and tumbling.
Dicranopteris amplachinget Chiu：The big plumage awns beanstalk of alias.Source medicine elementary source：For the tender seedling and medulla of Li Baike plant Dicranopteris amplachinget Chius.Nature and flavor
Micro-sweet；It is flat；It is puckery.Channel tropism Liver Channel.Major function：Removing toxic substances；Hemostasis.Main centipde-bite；Nosebleed epistaxis；Traumatism and bleeding.
Pseudo-ginseng：It is warm-natured, sweet, slight bitter, Return liver, stomach with hemostasis, dissipate the stasis of blood, detumescence, the effect of analgesic is cured mainly：Control and tell
Blood, hemoptysis, bleeding from five sense organs or subcutaneous tissue is had blood in stool, bloody flux, uterine bleeding, abdominal mass, postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatism and bleeding, carbuncle swells pain
Deng card, modern pharmacology proves, pseudo-ginseng can stop blooding, antithrombotic, promote hematopoiesis, anti-inflammatory, liver protection, antitumor, analgesia, to angiocarpy
Play the role of good, have protective effect to myocardial damage.
Rascal：Bitter, pungent, warm-natured, enter liver, courage, stomach, with the effect that easypro courage relieving stagnant Qi, disperse accumulationsization are stagnant, for dyspepsia gas
Stagnant, abdominal distention, infantile malnutrition, old man stops eating abdominal distension, there is gentle stimulation to intestines and stomach, can promote digestive juice secretion and
Internal gas, and energy diastole gastrointestinal smooth muscle are excluded, the effect of adjustment gastrointestinal function is mainly shown as.
Dentiferous dendropanax root and stem：Source medicine elementary source：For root, stem or the bark of Araliaceae authority ginseng or change leaf tree ginseng.Nature and flavor taste
It is sweet；It is pungent；It is warm-natured.Major function：Dispelling wind and eliminating dampness；Activating blood circulation and reducing swelling.Main arthralgia pain due to rheumatism；Hemiplegia；Headache；Irregular menstruation；Traumatic injury；
Sore swells.
Radix zanthoxyli：It is mild-natured, it is bitter, pungent, it is slightly poisonous, return stomach, Liver Channel, promoting qi circulation and relieving pain, promoting blood circulation and removing blood stasis, dispelling wind and removing obstruction in the meridians.
Common bombax flower：Nature and flavor：It is sweet；It is light；It is cool in nature.Channel tropism：Spleen；Liver；Large intestine channel.Major function：Heat-clearing；Dampness removing；Removing toxic substances；Only
Blood.Main diarrhea；Dysentery；Hemoptysis；Spit blood；Metrorrhagia；Metal-inflicted wound bleeding；Sore；Eczema.
Curcuma zedoary：Nature and flavor：Acrid, bitter, warm；Channel tropism：Return liver, the spleen channel.Function：Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.For Dan lump in the abdomen ruffians
Block, blood stasis closed, dyspepsia distending pain；Early cervical carcinoma.
Eupatorium is pungent, cold in nature, returns spleen, stomach, with stomach invigorating, diuresis, clearing damp, menstruation regulating, stagnation resolvation, soothing the liver, Xie Yu, qi-regulating,
The effects such as invigorating the spleen, breathing can be suppressed, make decreased heart rate, temperature decline and causes all diseases of glycosuria at hyperglycemia.
Fragrant structure：Alias rattan structure, Wa Wapi, wild cotton skin, yellow structure skin.Source medicine elementary source：For Isolated From Thymelaeaceae Species little Huang structures
Stem skin and root.Nature and flavor are sweet；It is mild-natured.Channel tropism lung channel.Major function：It is relieving cough and reducing sputum；Heat reliving and toxin-eliminating.Main cough and asthma；Pertussis；Carbuncle swells
Sore；Acute toothache.
The bark of official magnolia：It is bitter, pungent, temperature.Returns spleen, stomach, lung, large intestine channel.Effect is with curing mainly：Eliminating dampness dissolving phlegm, lower gas removes full.For humidity hysteresis
In wound, abdominal swelling and diarrhea, stagnation of QI due to dyspepsia, abdominal distention constipation, sputum cough.
Luffa：Source：Medicine elementary source：For cucurbitaceous plant sponge gourd or the vascular bundle of sponge gourd ripening fruits difficult to understand.Nature and flavor：Taste
It is bitter；It is cool in nature.Channel tropism：Return lung；Liver；Stomach.Major function：It is clearing and activating the channels and collaterals；Removing toxicity for detumescence.Main pain in chest and hypochondrium；Arthralgia pain due to rheumatism, passages through which vital energy circulates
Contraction, alactation, the cough of lung gesture, carbuncle future sore, his carbuncle.
Blood clam：Nature and flavor：It is salty, put down.Channel tropism：Return lung, stomach, Liver Channel.Effect：Dissolving phlegm stagnation resolvation, softening and resolving hard mass, relieving haperacidity stops
Bitterly.Accumulate and tie for stupid phlegm, sticky difficulty is coughed up, goiter and tumor, scrofula, abdominal mass lump in the abdomen, pantothenic acid of having a stomachache.
Fructus Malvae Vertillatae：Alias chingma abutilon seed.This strain of originating Mongols conventional crude drugs, are malvaceae plant winter certain herbaceous plants with big flowers Malva
Verticillata L. dry mature fruit.Harvested when summer, two season of autumn fruit maturation, remove impurity, dry in the shade.Nature and flavor are sweet,
It is puckery, it is cool.Major function：Reducing fever and causing diuresis, detumescence.For renal shutdown, oedema is thirsty；Urinary tract infections.Take passages《Chinese Pharmacopoeia》
Cinnamomum japonicum：Alias nandina osmanthus, obtuseleaf cinnamom bark, wild osmanthus.Source：Lauraceae cinnamon cinnamomum japonicum Cinnamomum
Japonicum Sieb., are used as medicine with bark and leaf.Whole year can adopt, and peel bark and dry in the shade；Leaf can be adopted at any time, using fresh herb or be dried in the shade.Property
Taste：Sweet, acrid, warm.Major function：Warming spleen and stomach for dispelling cold, regulating qi-flowing for relieving pain.For having a stomachache, stomachache, rheumatic arthritis；Bruise damage is controlled in external application
Wound.
Basil：It is warm-natured, it is pungent.Return lung warp, the spleen channel, stomach, large intestine channel.Effect and effect：Expelling wind to resolve the exterior, wind-dispelling disappear
Swollen, blood stasis removing analgesic, invigorate blood circulation.Belong to the warm-pungent diaphoretic drug of diaphoretic medicine subordinate classification.
The coptis, it is bitter, tremble with fear.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Major function：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For wet
Hot feeling of fullness, vomits acid regurgitation, and rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache is quenched one's thirst,
Carbuncle swells furunculosis；Eczema is controlled outside, wet sore, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and
Stomach preventing or arresting vomiting.Mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, vomiting is gulped down
Acid.
Radix scutellariae has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, it is the infection of the upper respiratory tract, cough with lung heat, wet
The diseases such as hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle sore.
Sculellaria barbata：Source：Medicine elementary source：For the herb of labiate Sculellaria barbata.Nature and flavor：It is pungent；It is bitter；It is cold in nature.Channel tropism：
Return lung；Liver；Kidney channel.Major function：It is clearing heat and detoxicating；Dissipate stasis of blood hemostasis；Inducing diuresis to remove edema.Main heat toxin carbuncle swells；Have sore throat；Lung carbuncle；Intestines
Carbuncle；Scrofula；Venomous snake bite；Traumatic injury；Spit blood；Bleeding from five sense organs or subcutaneous tissue；Blood strangury；Oedema；Ascites and cancer.
Asian puccoon：It is cold in nature, it is sweet, salty.The thoughts of returning home, Liver Channel.Its major function：Cool blood, promoting blood circulation, promoting eruption of detoxifying.
Evodia rutaecarpa, pungent, hardship, heat；It is slightly poisonous.Return liver, spleen, stomach, kidney channel.Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.With
In jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhoea, dysmenorrhea, abdominal distention vomits acid regurgitation, Diarrhoea, Wai Zhikou
Sore；Hypertension.
The tuber of pinellia：It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system head
Bitterly, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；Controlling outward carbuncle swells subcutaneous nodule is used in life.
Dried orange peel is warm-natured, pungent, bitter.Enter the spleen channel, stomach, lung channel.In regulating qi-flowing for strengthening spleen, tune, eliminating dampness, resolving sputum.Cure mainly taste
The abdominal fullness and distention or pain of the stagnation of the circulation of vital energy, indigestion.Abdominal distension uncomfortable in chest, indigestion and loss of appetite loose stool in wet turbid resistance.The cough and asthma of phlegm obstructing lung.
For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.《Compendium of Materia Medica》：It is to hundred and always takes the work(of chess qi-regulating eliminating dampness, same to tonic
Then mend, then rushed down with cathartic, then risen with hydrargyrum oxydatum crudum, then dropped with drop medicine.Spleen is the mother of vigour, and lung is to take the photograph wanting for gas, therefore orange peel is two warps
Qi leel will, but with match somebody with somebody and reinforcing and reducing methods lift.《Daily book on Chinese herbal medicine》：Can dissipate to rush down, and warm can mend, can disappear diaphragm gas, resolving sputum saliva, and
Spleen, which stops, coughs, and leads to five and drenches.
Poria cocos：Base：This product is the dry sclerotia of On Polyporaceae Poria cocos.Chemical analysis：Sclerotium contains β-pachyman
Account for dry weight 93% and triterpene compound Pachymic acid, pachymic acid, 3 beta-hydroxy wool steroid trienic acids.In addition, Shang Hanshu
Glue, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β-pachyman catabolic enzyme,
Lipase, protease etc..Nature and flavor：It is sweet, light, put down.Channel tropism：The thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen calming heart.It is main
Control：For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
The gastrointestinal B-ultrasonic of the present invention is low with Chinese medicine assistant cost, easy to use, safe to have no toxic side effect, it is possible to increase excellent
Good development ratio, improves and checks accuracy, more gastrointestinal diseases is checked by B ultrasound, provided for clinical diagnosis
Strong foundation, and preparation technology is simple, practical.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with embodiment to this hair
Bright technical scheme is clearly and completely described.Obviously, described embodiment is the part of the present invention, rather than entirely
The embodiment in portion.Based on described embodiments of the invention, those of ordinary skill in the art are before without creative work
The every other embodiment obtained is put, the scope of protection of the invention is belonged to.
Embodiment 1：
A kind of B ultrasound Chinese medicine assistant of the present invention, takes following traditional Chinese medicine raw medicine：8 parts of cape jasmine, 5 parts of aloe, 1 part of rhizoma atractylodis,
10 parts of dandelion, 5 parts of myrrh, 16 parts of cortex albiziae, 10 parts of Dicranopteris amplachinget Chiu, 8 parts of pseudo-ginseng, 5 parts of rascal, 1 part of dentiferous dendropanax root and stem, Radix zanthoxyli 10
Part, 15 parts of common bombax flower, 3 parts of curcuma zedoary, 3 parts of eupatorium, fragrant 5 parts of structure, 12 parts of the bark of official magnolia, 16 parts of luffa, 3 parts of blood clam, Fructus Malvae Vertillatae 12
Part, 12 parts of cinnamomum japonicum, 6 parts of Basil, 8 parts of the coptis, 3 parts of radix scutellariae, 15 parts of Sculellaria barbata, 5 parts of Asian puccoon, 10 parts of evodia rutaecarpa, the tuber of pinellia 9
Part, 15 parts of dried orange peel, 15 parts of Poria cocos.
Embodiment 2：
A kind of B ultrasound Chinese medicine assistant of the present invention, takes following traditional Chinese medicine raw medicine：13 parts of cape jasmine, 3 parts of aloe, rhizoma atractylodis 3
Part, 5 parts of dandelion, 10 parts of myrrh, 13 parts of cortex albiziae, 3 parts of Dicranopteris amplachinget Chiu, 13 parts of pseudo-ginseng, 3 parts of rascal, 3 parts of dentiferous dendropanax root and stem, Radix zanthoxyli 5
Part, 9 parts of common bombax flower, 7 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 8 parts of structure, 15 parts of the bark of official magnolia, 10 parts of luffa, 8 parts of blood clam, 5 parts of Fructus Malvae Vertillatae,
17 parts of cinnamomum japonicum, 4 parts of Basil, 10 parts of the coptis, 4 parts of radix scutellariae, 13 parts of Sculellaria barbata, 6 parts of Asian puccoon, 12 parts of evodia rutaecarpa, 4 parts of the tuber of pinellia,
20 parts of dried orange peel, 10 parts of Poria cocos.
Embodiment 3：
A kind of B ultrasound Chinese medicine assistant of the present invention, takes following traditional Chinese medicine raw medicine：9 parts of cape jasmine, 4 parts of aloe, 2 parts of rhizoma atractylodis,
6 parts of dandelion, 6 parts of myrrh, 14 parts of cortex albiziae, 5 parts of Dicranopteris amplachinget Chiu, 10 parts of pseudo-ginseng, 4 parts of rascal, 2 parts of dentiferous dendropanax root and stem, 6 parts of Radix zanthoxyli,
10 parts of common bombax flower, 5 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 7 parts of structure, 13 parts of the bark of official magnolia, 11 parts of luffa, 4 parts of blood clam, 6 parts of Fructus Malvae Vertillatae, day
13 parts of Zhu Gui, 5 parts of Basil, 12 parts of the coptis, 3 parts of radix scutellariae, 12 parts of Sculellaria barbata, 9 parts of Asian puccoon, 7 parts of evodia rutaecarpa, 5 parts of the tuber of pinellia, dried orange peel
18 parts, 11 parts of Poria cocos.
Wherein, described pharmaceutical composition is prepared in following manner：
(1) each medicinal material of the components by weight percent is taken, 10-12 times of water of dosing material gross weight, after immersion 45-75 minutes,
Decoct 1 time, decocting time 3-3.5 hours, after filtration, 8-10 times of water of dosing material gross weight is decocted the 2nd time, decocting time
2.5-3 hours, after filtration, 6-8 times of water of dosing material gross weight was decocted the 3rd time, decocting time 2-2.5 hours, after filtration,
Merge 3 filtrates, the filtration of 120 mesh, it is 1.12~1.15 that filtrate, which is heated and is concentrated into relative density at 60 DEG C, obtains concentrate, sprays
Dry, 80~85 DEG C of 170~175 DEG C of EAT, the leaving air temp of spray dryer is then ground into powder, 80 mesh are made
Fine powder；
(2) 80 mesh fine powders made from step (1) are added into appropriate auxiliary material and granule, capsule, tablet is made.
Toxicity test：
Using NIH mouse 40, SPF grades, male and female half and half, 22~27g of body weight carries out acute toxicity testing.Mouse is random
It is divided into two groups, i.e. control group and administration group, fasting 12 hours, Chinese medicine composition prepared by embodiments of the invention 1 before experiment
Granule is dissolved in water, (concentration is 6.33g crude drugs/ml, maximum concentration) gavage, and gavage volume is that 5ml/kg (i.e. give by single
Pharmaceutical quantities are 31.65g crude drugs/kg), control group gives normal saline, is administered 2 times within 1 day, delivery time 6 hours is given
Continuous Observation 14 days after medicine, and the toxic reaction and death toll of mouse are recorded, specifically refer to table 1.Test result indicates that：With compareing
Group compares, and mouse has no notable difference after administration, experiment Continuous Observation 14 days, mouse systemic situation, ingest, drink water, body weight increases
Length is normal.The capsule LD of the Mouse oral gavage present invention50＞ 31.65g crude drugs/kg, daily maximum dosage-feeding is given birth to for 63.3g
Medicine/kg/ days.The Chinese medicine composition clinical application amount of the present invention is 2.1g crude drugs/day/people, and adult's body weight is average to use in terms of 60kg
Pharmaceutical quantities are 0.035g crude drugs/kg/ days.By batheroom scale：The Chinese medicine group of mouse (average weight is in terms of 20g) oral administration gavage present invention
The dosis tolerata of compound is 899 times of quantity.Therefore the Chinese medicine composition acute toxicity of the present invention is low, clinical application safety.
Clinical reasoning：
In order to verify the effect of Chinese medicine composition of the present invention, 2 months in November, 2014-2016 year, 176 are randomly choosed at outpatient service
Example hemodialysis patients cutaneous lesions patient, because upset,gastro-intestinal needs to carry out being in hospital or out-patient for B ultrasound or gastrocopy, man
90, female 86, age 22-65 Sui.
Test method：It is required that fasting for solids and liquids after patient's 10 points of evening before that day of inspection, checked in the morning.First carry out B
Super to check, gastrocopy is then carried out again to be confirmed and is compareed.
Ultrasound diagnosis method：3, the tablet of the oral present invention, then drinks 200-300ml warm waters, drinks latter 2-5 minutes
Checked.Check position：Based on horizontal position and right lateral position, it is aided with left lateral position and semireclining position；Operating method：Press stomach,
Duodenum belly body surface projection, successively from orifice of the stomach, stomach bottom, curved body of stomach stomach size, gastric angle, gastric antrum pylorus pipe
Continuous whole scanning is done with duodenum, makes every effort to clearly show Stomach duodenum ultrasonogram overall picture, primary part observation stomach orifice of the stomach,
Lesser curvature, stomach angle, stomach pyloric canal and duodenal bulb；Examine each position of stomach, wall of stomach thickness, hierarchical structure, wriggling and
The imaging characteristic of lesion region, stomach lining continued integrity etc..
Development criterion：
It is excellent：Developer is full good, and bubble-free and mucus interference in coat of the stomach, gastric mucosa face are shown clearly, five layers of coat of the stomach
Clear in structure is distinguishable.
Typically：Developer is full good, there is a small amount of bubble and mucus interference in coat of the stomach, and mucosal surface shows more visible, coat of the stomach
Five-layer structure is still clear, but does not influence detection.
It is bad：Stomach intracavitary has a large amount of bubbles and mucus, and mucosal surface shows unclear, and coat of the stomach level is beyond recognition, influence detection.
Result of the test
Result of the test statistical analysis is as shown in table 1：
The development situation statistics of table 1 is as follows：
| Number of cases | It is excellent | Typically | It is bad |
| 176 | 171 (97.2%) | 5 (2.8%) | 0 (0%) |
Observe drug response：176 patients of this group, are seen after being taken medicine according to sex, age, disease, constitution, season etc.
Examine, be summarized as follows：(1) 176 patient does not occur adverse reaction after the tablet has been ingested, and patient tolerance is good；(2) after some patientss are drunk
The comfort that has an appetite and unobstructed sense, reflection drug tastes preferably, phenomenon are taken without detesting；(3) drink gastric B ultrasonic examination Chinese medicine assistant and carry out stomach
Ultrasound diagnosis, patient, no pain are easy to receive, and can smoothly complete the ultrasound diagnosis of stomach.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic；
And these modifications or replacement, the essence of appropriate technical solution is departed from the scope of various embodiments of the present invention technical scheme.
Claims (5)
1. a kind of B ultrasound Chinese medicine assistant, it is characterised in that：The raw material composition and parts by weight of the Chinese medicine assistant is made
For：8-13 parts of cape jasmine, 3-5 parts of aloe, 1-3 parts of rhizoma atractylodis, 5-10 parts of dandelion, 5-10 parts of myrrh, 13-16 parts of cortex albiziae, big awns
3-10 parts of beanstalk, 8-13 parts of pseudo-ginseng, 3-5 parts of rascal, 1-3 parts of dentiferous dendropanax root and stem, 5-10 parts of Radix zanthoxyli, 9-15 parts of common bombax flower, curcuma zedoary 3-7
Part, 3-4 parts of eupatorium, fragrant structure 5-8 parts, 12-15 parts of the bark of official magnolia, 10-16 parts of luffa, 3-8 parts of blood clam, 5-12 parts of Fructus Malvae Vertillatae, day
12-17 parts of Zhu Gui, 4-6 parts of Basil, 8-12 parts of the coptis, 3-4 parts of radix scutellariae, 12-15 parts of Sculellaria barbata, 5-9 parts of Asian puccoon, evodia rutaecarpa 7-
12 parts, 4-9 parts of the tuber of pinellia, 15-20 parts of dried orange peel, 10-15 parts of Poria cocos.
2. B ultrasound according to claim 1 Chinese medicine assistant, it is characterised in that：The raw material of the Chinese medicine assistant is made
Composition and parts by weight are：8 parts of cape jasmine, 5 parts of aloe, 1 part of rhizoma atractylodis, 10 parts of dandelion, 5 parts of myrrh, 16 parts of cortex albiziae, Dicranopteris amplachinget Chiu
10 parts, 8 parts of pseudo-ginseng, 5 parts of rascal, 1 part of dentiferous dendropanax root and stem, 10 parts of Radix zanthoxyli, 15 parts of common bombax flower, 3 parts of curcuma zedoary, 3 parts of eupatorium, fragrant 5 parts of structure,
12 parts of the bark of official magnolia, 16 parts of luffa, 3 parts of blood clam, 12 parts of Fructus Malvae Vertillatae, 12 parts of cinnamomum japonicum, 6 parts of Basil, 8 parts of the coptis, radix scutellariae 3
Part, 15 parts of Sculellaria barbata, 5 parts of Asian puccoon, 10 parts of evodia rutaecarpa, 9 parts of the tuber of pinellia, 15 parts of dried orange peel, 15 parts of Poria cocos.
3. B ultrasound according to claim 1 Chinese medicine assistant, it is characterised in that：The raw material of the Chinese medicine assistant is made
Composition and parts by weight are：13 parts of cape jasmine, 3 parts of aloe, 3 parts of rhizoma atractylodis, 5 parts of dandelion, 10 parts of myrrh, 13 parts of cortex albiziae, big awns
3 parts of beanstalk, 13 parts of pseudo-ginseng, 3 parts of rascal, 3 parts of dentiferous dendropanax root and stem, 5 parts of Radix zanthoxyli, 9 parts of common bombax flower, 7 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 8 parts of structure,
15 parts of the bark of official magnolia, 10 parts of luffa, 8 parts of blood clam, 5 parts of Fructus Malvae Vertillatae, 17 parts of cinnamomum japonicum, 4 parts of Basil, 10 parts of the coptis, radix scutellariae 4
Part, 13 parts of Sculellaria barbata, 6 parts of Asian puccoon, 12 parts of evodia rutaecarpa, 4 parts of the tuber of pinellia, 20 parts of dried orange peel, 10 parts of Poria cocos.
4. B ultrasound according to claim 1 Chinese medicine assistant, it is characterised in that：The raw material of the Chinese medicine assistant is made
Composition and parts by weight are：9 parts of cape jasmine, 4 parts of aloe, 2 parts of rhizoma atractylodis, 6 parts of dandelion, 6 parts of myrrh, 14 parts of cortex albiziae, Dicranopteris amplachinget Chiu 5
Part, 10 parts of pseudo-ginseng, 4 parts of rascal, 2 parts of dentiferous dendropanax root and stem, 6 parts of Radix zanthoxyli, 10 parts of common bombax flower, 5 parts of curcuma zedoary, 4 parts of eupatorium, fragrant 7 parts of structure is thick
13 parts of Piao, 11 parts of luffa, 4 parts of blood clam, 6 parts of Fructus Malvae Vertillatae, 13 parts of cinnamomum japonicum, 5 parts of Basil, 12 parts of the coptis, 3 parts of radix scutellariae,
12 parts of Sculellaria barbata, 9 parts of Asian puccoon, 7 parts of evodia rutaecarpa, 5 parts of the tuber of pinellia, 18 parts of dried orange peel, 11 parts of Poria cocos.
5. B ultrasound according to claim 1 Chinese medicine assistant, it is characterised in that：The Chinese medicine assistant is according to following side
It is prepared by method：
(1) each medicinal material of the components by weight percent is taken, 10-12 times of water of dosing material gross weight after soaking 45-75 minutes, decocts 1
It is secondary, decocting time 3-3.5 hours, after filtration, 8-10 times of water of dosing material gross weight is decocted the 2nd time, decocting time 2.5-3
Hour, after filtration, 6-8 times of water of dosing material gross weight is decocted the 3rd time, decocting time 2-2.5 hours, after filtration, merges 3
Secondary filtrate, the filtration of 120 mesh, it is 1.12~1.15 that filtrate heating, which is concentrated into relative density at 60 DEG C, obtains concentrate, is spray-dried,
80~85 DEG C of 170~175 DEG C of EAT, the leaving air temp of spray dryer, is then ground into powder, and 80 mesh fine powders are made；
(2) 80 mesh fine powders made from step (1) are added into appropriate auxiliary material and granule, capsule, tablet is made.
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| CN201710145138.4A CN106963953A (en) | 2017-03-13 | 2017-03-13 | A kind of B ultrasound Chinese medicine assistant |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949734A (en) * | 2012-09-18 | 2013-03-06 | 王玉云 | Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof |
| CN104873988A (en) * | 2015-06-12 | 2015-09-02 | 姜丽丽 | TCM (Traditional Chinese Medicine) developing assistant agent for B-scan ultrasonography image and preparation method thereof |
| CN105833300A (en) * | 2016-03-24 | 2016-08-10 | 薛要红 | Gastrointestinal B-ultrasonic traditional Chinese medicine co-imaging agent and preparation method thereof |
-
2017
- 2017-03-13 CN CN201710145138.4A patent/CN106963953A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949734A (en) * | 2012-09-18 | 2013-03-06 | 王玉云 | Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof |
| CN104873988A (en) * | 2015-06-12 | 2015-09-02 | 姜丽丽 | TCM (Traditional Chinese Medicine) developing assistant agent for B-scan ultrasonography image and preparation method thereof |
| CN105833300A (en) * | 2016-03-24 | 2016-08-10 | 薛要红 | Gastrointestinal B-ultrasonic traditional Chinese medicine co-imaging agent and preparation method thereof |
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Application publication date: 20170721 |