CN103432528A - Chinese medicinal preparation for treating non-alcoholic fatty liver disease - Google Patents

Abstract

The invention provides a Chinese medicinal preparation for treating non-alcoholic fatty liver disease. The Chinese medicinal preparation is prepared from bupleurum, radix paeoniae alba, mint, fiveleaf akebia fruit, immature bitter orange, marigold flower, dried tangerine peel, pinellia ternate, beonninghausenia sessilicarpa, paniculate swallowwort root, turmeric, rhizoma alismatis, rhizoma corydalis, hawthorn and liquorice.

Description

A kind of Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease

Technical field

The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease.

Background technology

Non-alcohol fatty liver is a kind of of fatty liver, and pathogenesis is thought stagnation of liver-QI with deficiency of the spleen, retention of damp-heat in the interior, qi depression to blood stasis, phlegm and blood stasis more, and final numbness resistance liver venation causes fatty liver, and expectorant, wet, the stasis of blood etc. are the key of pathogenesis.Chinese medicine uses the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs theory, and treatment non-alcoholic fatty liver disease curative effect certainly.The Chinese medicine preparation treatment non-alcoholic fatty liver disease that the present invention prepares through long-term practice, obtain good effect.

Summary of the invention

The object of the present invention is to provide the Chinese medicine preparation of the treatment non-alcoholic fatty liver disease that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect.

The objective of the invention is according to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, adopt Radix Bupleuri, the Radix Paeoniae Alba, Herba Menthae, Fructus Akebiae, Fructus Aurantii Immaturus, marigold flower, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Herba Boenninghauseniae, Radix Cynanchi Paniculati, Rhizoma Curcumae Longae, Rhizoma Alismatis, Rhizoma Corydalis, Fructus Crataegi, Radix Glycyrrhizae, according to certain compatibility requirement, through being processed into.

Preparing Chinese medicine preparation of the present invention is made by following raw material medicaments: Radix Bupleuri 20-35 part, Radix Paeoniae Alba 20-35 part, Herba Menthae 15-25 part, Fructus Akebiae 15-25 part, Fructus Aurantii Immaturus 15-25 part, marigold flower 15-25 part, Pericarpium Citri Reticulatae 10-20 part, Rhizoma Pinelliae 10-20 part, Herba Boenninghauseniae 10-20 part, Radix Cynanchi Paniculati 10-20 part, Rhizoma Curcumae Longae 5-10 part, Rhizoma Alismatis 5-10 part, Rhizoma Corydalis 5-10 part, Fructus Crataegi 5-10 part, Radix Glycyrrhizae 5-10 part.

Optimum weight part of Chinese medicine preparation crude drug of the present invention is: 30 parts of Radix Bupleuri, 30 parts of the Radix Paeoniae Albas, 20 parts of Herba Menthaes, 20 parts of Fructus Akebiaes, 20 parts of Fructus Aurantii Immaturuss, 20 parts of marigold flowers, 15 parts of Pericarpium Citri Reticulataes, 15 parts of the Rhizoma Pinelliaes, 15 parts of Herba Boenninghauseniaes, 15 parts of Radix Cynanchi Paniculatis, 8 parts, Rhizoma Curcumae Longae, 8 parts of Rhizoma Alismatis, 8 parts of Rhizoma Corydalis, 8 parts of Fructus Crataegis, 8 parts, Radix Glycyrrhizae.

The pharmacological action of Chinese medicine of the present invention is as follows:

Radix Bupleuri: bitter, hot, be slightly cold, return liver, gallbladder meridian.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI.For stagnation of QI due to depression of the liver, pain in chest and hypochondrium.

The Radix Paeoniae Alba: bitter, sour, be slightly cold, return liver, spleen channel.Nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly the blood deficiency cold and heat, epigastric pain, have a headache dizzy.

Herba Menthae: hot, cool, GUIXIN, lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, dispersing the stagnated live-QI to relieve the stagnation of QI.For anemopyretic cold, epidemic febrile disease from the beginning of, measles without adequate eruption, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest etc.

Fructus Akebiae: micro-hardship, property are put down.Return liver, stomach, urinary bladder channel.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.For stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor etc.

Fructus Aurantii Immaturus: bitter, acrid, cold.Return spleen, stomach, liver, heart channel.The dispelling the stagnated QI removing food stagnancy, reduce phlegm except painful abdominal mass.Stop feeling of fullness distending pain, constipation, gastroptosis, proctoptosis etc. in stagnant.

Marigold flower: bitter, cool.Heat-clearing and toxic substances removing, cough-relieving.For anemopyretic cold, cough, dysentery, parotitis, acute mastitis, toothache, oral inflammation, conjunctival congestion and swelling pain.

Pericarpium Citri Reticulatae: acrid, bitter, warm, return spleen, stomach, lung meridian.In regulating the flow of vital energy and adjusting, stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm.Full vexed for chest and diaphragm, abdominal distention, anorexia, vomiting etc.

The Rhizoma Pinelliae: hot, temperature, poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Cure mainly the cough with asthma abundant expectoration, feeling of oppression and fullness in the chest and epigastrium, have a headache dizzy etc.

Herba Boenninghauseniae: suffering; Bitter; Cool in nature.Lung; The stomach warp.Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, promoting flow of QI and blood.For flu, tonsillitis, bronchitis, pneumonia, pyelonephritis, stomachache abdominal distention, thromboangiitis obliterans, lumbago, traumatic injury etc.

Radix Cynanchi Paniculati: hot, hot, return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching, promoting blood circulation and detoxication, detumescence, for gastropathy, is had a toothache, rheumatic arthralgia, lumbago, epigastric pain, cholecystitis, the urine water conservancy, have loose bowels, dysentery, eczema, urticaria, venom.

Rhizoma Curcumae Longae: bitter in the mouth, suffering, warm in nature.Return spleen, Liver Channel.The removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.The all cards of stagnation of QI and blood, born of the same parents' abdomen hypochondriac pain, dysmenorrhes, the stagnant stomachache of the stasis of blood in puerperal, rheumatic arthralgia, traumatic injury, carbuncle etc.

Rhizoma Alismatis: sweet, light, cold.Return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, expel the heat-evil.For edema, dysuria, have loose bowels, stranguria with turbid discharge leukorrhagia and phlegm retention etc.

Rhizoma Corydalis: acrid, bitter, warm.Return liver, stomach, the heart, lung, spleen channel.Invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving.For all pains of trusted subordinate's waist knee joint, menoxenia, traumatic injury etc.

Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, the circulation of qi promoting dissipating blood stasis.For eating accumulation, abdominal distention, dysentery, hernia swells and ache etc.

Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.The QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.For severe palpitation, the irregularly intermittent and regularly intermittent pulse of deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.

Chinese medicine preparation of the present invention is used in 2006 to 2012 clinical observation non-alcoholic fatty liver disease disease 130 routine patients, and clinical report is as follows:

1, physical data

In 130 routine patients, women's 68 examples, male's 62 examples, minimum 32 years old of age, maximum 66 years old, 44.5 years old mean age.

2, diagnostic criteria

Reference " traditional Chinese medical science disease Standardization of diagnosis and curative effect ":

1. without history of drinking history or drink and amount to amount of alcohol, the male weekly<40g.2. except, viral hepatitis, drug-induced liver disease, full gastrointestinal nutrition, hepatolenticular degeneration etc. can cause the specified disease of fatty liver.3. except the primary disease clinical manifestation, can accompany nonspecific symptom and the signs such as weak, dyspepsia, dull pain in liver, hepatosplenomegaly.4. can have weight overweight and (or) the metabolism syndrome associated change such as Abdominal obesity, fasting glucose increase, blood fat disorder, hypertension.5. serum transaminase and GGT level can have gently to mild or moderate and increase (<5 times of Upper Limit of Normal Values), usually with ALT, increase to the master.6. liver imaging is learned to show and is met diffusivity fatty liver imaging diagnosis main points.7. liver biopsy Histological change meets the pathological diagnosis main points of fatty liver.Above 7 possess 1.～5. and the 6. or the 7. in item any one can determine diagnosis.

3, Therapeutic Method

3.1 prescription: Radix Bupleuri 30g, Radix Paeoniae Alba 30g, Herba Menthae 20g, Fructus Akebiae 20g, Fructus Aurantii Immaturus 20g, marigold flower 20g, Pericarpium Citri Reticulatae 15g, Rhizoma Pinelliae 15g, Herba Boenninghauseniae 15g, Radix Cynanchi Paniculati 15g, Rhizoma Curcumae Longae 8g, Rhizoma Alismatis 8g, Rhizoma Corydalis 8g, Fructus Crataegi 8g, Radix Glycyrrhizae 8g.

3.2 preparation and instructions of taking: said medicine technique is routinely made decoction, and oral each 1 dose every day 2 times, 10 days is a course for the treatment of.

4, therapeutic outcome:

4.1 reference " traditional Chinese medical science disease Standardization of diagnosis and curative effect ":

Clinical cure: clinical symptoms and sign disappear, and liver B ultrasonic or CT examination, lab testing recover normal;

Produce effects: clinical symptoms and sign are obviously improved, and liver B ultrasonic or CT examination take a turn for the better obviously, and the indices of lab testing descends more than 40%;

Do not heal: clinical symptoms and sign are improved not obvious, and before and after liver B ultrasonic or CT examination treatment, without significant change, the indices of lab testing is without obvious decline.

4.2 result: in 130 routine patients, clinical cure 69 examples (53%), produce effects 48 examples (37%), 13 examples (10%) that do not heal, total effective rate is 90%.

5, model case

5.1 the section certain, the female, 48 years old, liver function was shown glutamate pyruvate transaminase (ALT) 75U/L, glutamic oxaloacetic transaminase, GOT (AST) 45U/L, glutamyl transpeptidase (r-GGT): 59U/L, blood fat: cholesterol 5.6mmol/1, triglyceride 5.7mmol/L.CT shows: severe fatty liver.Take medicine of the present invention, treat 3 courses for the treatment of, all diseases alleviate, and continue to take 3 courses for the treatment of, and check liver function, blood fat is all normal, and CT shows: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.After half a year, follow up a case by regular visits to without recurrence.

5.2 the Wang, the man, 51 years old, the inspections such as making liver function, blood fat, color ultrasound, CT of having a medical check-up, be diagnosed as non-alcoholic fatty liver disease.Blood fat is higher, and the transaminase is high.Examine and see red tongue with yellowish and greasy fur, slippery and rapid pulse.Take medicine of the present invention, 1 dose of every day, after 3 courses for the treatment of, all diseases alleviate, and continue to take 2 courses for the treatment of, and check liver function, blood fat is all normal, and CT shows: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.After half a year, follow up a case by regular visits to without recurrence.

The specific embodiment

Below in conjunction with embodiment, the present invention is further illustrated, and following this embodiment does not only limit the present invention for the present invention is described.

Embodiment 1, a kind of Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease, it is to be made by following raw material medicaments: Radix Bupleuri 20g, Radix Paeoniae Alba 20g, Herba Menthae 15g, Fructus Akebiae 15g, Fructus Aurantii Immaturus 15g, marigold flower 15g, Pericarpium Citri Reticulatae 10g, Rhizoma Pinelliae 10g, Herba Boenninghauseniae 10g, Radix Cynanchi Paniculati 10g, Rhizoma Curcumae Longae 5g, Rhizoma Alismatis 5g, Rhizoma Corydalis 5g, Fructus Crataegi 5g, Radix Glycyrrhizae 5g.

Embodiment 2, a kind of Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease, it is to be made by following raw material medicaments: Radix Bupleuri 30g, Radix Paeoniae Alba 30g, Herba Menthae 20g, Fructus Akebiae 20g, Fructus Aurantii Immaturus 20g, marigold flower 20g, Pericarpium Citri Reticulatae 15g, Rhizoma Pinelliae 15g, Herba Boenninghauseniae 15g, Radix Cynanchi Paniculati 15g, Rhizoma Curcumae Longae 8g, Rhizoma Alismatis 8g, Rhizoma Corydalis 8g, Fructus Crataegi 8g, Radix Glycyrrhizae 8g.

Embodiment 3, a kind of Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease, it is to be made by following raw material medicaments: Radix Bupleuri 35g, Radix Paeoniae Alba 35g, Herba Menthae 25g, Fructus Akebiae 25g, Fructus Aurantii Immaturus 25g, marigold flower 25g, Pericarpium Citri Reticulatae 20g, Rhizoma Pinelliae 20g, Herba Boenninghauseniae 20g, Radix Cynanchi Paniculati 20g, Rhizoma Curcumae Longae 10g, Rhizoma Alismatis 10g, Rhizoma Corydalis 10g, Fructus Crataegi 10g, Radix Glycyrrhizae 10g.

Claims (2)

1. a Chinese medicine preparation for the treatment of non-alcoholic fatty liver disease is characterized in that comprising following crude drug:

Radix Bupleuri 20-35 part, Radix Paeoniae Alba 20-35 part, Herba Menthae 15-25 part, Fructus Akebiae 15-25 part, Fructus Aurantii Immaturus 15-25 part, marigold flower 15-25 part, Pericarpium Citri Reticulatae 10-20 part, Rhizoma Pinelliae 10-20 part, Herba Boenninghauseniae 10-20 part, Radix Cynanchi Paniculati 10-20 part, Rhizoma Curcumae Longae 5-10 part, Rhizoma Alismatis 5-10 part, Rhizoma Corydalis 5-10 part, Fructus Crataegi 5-10 part, Radix Glycyrrhizae 5-10 part.

2. Chinese medicine preparation according to claim 1, its feature is comprising following crude drug:

30 parts of Radix Bupleuri, 30 parts of the Radix Paeoniae Albas, 20 parts of Herba Menthaes, 20 parts of Fructus Akebiaes, 20 parts of Fructus Aurantii Immaturuss, 20 parts of marigold flowers, 15 parts of Pericarpium Citri Reticulataes, 15 parts of the Rhizoma Pinelliaes, 15 parts of Herba Boenninghauseniaes, 15 parts of Radix Cynanchi Paniculatis, 8 parts, Rhizoma Curcumae Longae, 8 parts of Rhizoma Alismatis, 8 parts of Rhizoma Corydalis, 8 parts of Fructus Crataegis, 8 parts, Radix Glycyrrhizae.