CN105250634A - Traditional Chinese medicine composition for treating postpartum constipation and application thereof - Google Patents
Traditional Chinese medicine composition for treating postpartum constipation and application thereof Download PDFInfo
- Publication number
- CN105250634A CN105250634A CN201510835523.2A CN201510835523A CN105250634A CN 105250634 A CN105250634 A CN 105250634A CN 201510835523 A CN201510835523 A CN 201510835523A CN 105250634 A CN105250634 A CN 105250634A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- grams
- constipation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Provided are a traditional Chinese medicine composition for treating postpartum constipation and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 3-15 parts of licorice roots, 10-30 parts of donkey-hide glue, 20-50 parts of aloes, 12-40 parts of fructus lycii, 10-20 parts of herba portulacae, 10-30 parts of fructus cannabis, 10-25 parts of semen astragali complanati, 8-25 parts of cortex eucommiae, 5-15 parts of achyranthes bidentata, 7-26 parts of rhizoma anemarrhenae, 10-30 parts of caulis polygoni multiflori, 10-40 parts of rhodiola rosea, 20-50 parts of honey, 6-20 parts of poria cocos, 8-30 parts of cistanche salsa, 10-30 parts of cortex magnoliae officinalis, 10-20 parts of yams and 5-15 parts of motherwort herbs. The traditional Chinese medicine composition starts from incidence causes which produce constipation and is developed according to special groups of people, prenatal constipation and postpartum constipation are solved, Yin and Yang must be regulated, the liver and the kidney are nourished, Yin is nourished, the blood is supplemented, the lung is moistened, the secretion of saliva or body fluid is promoted, the brain is strengthened, nerves are calmed, the spleen is invigorated, Qi is replenished, bowels are loosened, the constipation is relieved, and taking traditional Chinese medicine composition is an effective way for treating the postpartum constipation. The traditional Chinese medicine composition can strengthen physical enginery and rapidly enhance improvement of postpartum immunity of pregnant women, drug dependence brought by only using western medicine can be avoided, and the effect of the traditional Chinese medicine composition is superior to that of traditional food therapy or only using western medicine.
Description
Technical field
The invention belongs to puerperal constipation treatment field, particularly relate to a kind of Chinese medicine composition being used for the treatment of puerperal constipation and uses thereof.
Background technology
Constipation and constipation obstructed, be the common disease because many reasons causes.ZHU Dan-xi is recorded in " danxi's experiential therapy " " Qi and blood deficiency, lights a fire in intestinal, empty sit anger duty ", illustrates that deficiency of qi and blood is the main cause causing constipation due to deficiency syndrome, and women is antenatal, puerperal many deficiency of qi and blood; From study of pharmacy, the aspects such as theory analysis find that gastrointestinal peristalsis is slowed down, during stool, firmly deficiency is another main cause producing constipation, due to current growth in the living standard, the fetus bred is larger, and carry out caesarean delivered number and get more and more, Celiotomy Wean puerpera is owing to fearing pain, dare not exert oneself during stool, and cause straining at stool not enough; Cause the third reason of puerpera's constipation: childbirth, hormone hormone and childbirth time use anesthetis, Celiotomy Wean dare not all make the wriggling of intestinal slow down by out-of-bed activity.Found by long-term clinical observation, the puerpera of more than 80% there will be constipation puerperal.
There is after constipation more firmly defecation in puerpera, can occur serious consequence: first can make health weaker, and second to cut for side or caesarean delivered women the lighter increases the weight of wound pain, heavy then cause disruption of wound to delay wound healing.Therefore antenatal first anti-postpartum therapy is the key for the treatment of puerperal constipation.Puerperal constipation is the symptom of puerpera Chang You, being mostly because puerperal loses blood hyperamization void, the deficiency of vital energy, Tianjin wound, as treated not in time, often causing hemorrhoid, dehydration, anal fissure even to occur a series of sequela such as uterine prolapse.During parturient childbirth, blood loses cruelly, and body fluid is the ingredient of blood.Because damage of essence blood damages, insufficiency of vital energy and blood, essence and blood void at least intestinal is lost in moistening, and the deficiency of vital energy then large intestine transmits unable, so that constipation.Clinical card is shown in that defecate puerperal is not understood a few days, or time just under dry pain difficulty, but abdomen is not bitterly, receive and eat as usual, shallow complexion few China or white, skin does not moisten or has giddy, cardiopalmus, breathe hard, tired, light red tongue thready and weak pulse, therefore the many genus of puerperal constipation " deficiency syndrome " category, certainly will suffer tremendous loss in strength or resources more with high violent logical agent of rushing down.Therefore, puerperal constipation must be focused on controlling " basis ", and adding the raw liquid in Tianjin clinically to fill blood is principle, as long as accurately dialectical, cut out proper, really can produce effects with diseaseization.Also have the puerperal constipation that can treat such as in current Chinese medicine:
Chinese patent application CN101181508A discloses a kind of Chinese medicinal formulae of orally taken for curing constipation, is made up of the effective ingredient of following weight: Rhizoma Atractylodis Macrocephalae 10 grams, Radix Paeoniae Alba 10 grams, Radix Glycyrrhizae 20 grams, Radix Et Rhizoma Rhei 6 grams, Radix Angelicae Sinensis 20 grams, 12 grams, the Radix Rehmanniae, Fructus Cannabis 15 grams, Herba Cistanches 12 grams, Radix Ophiopogonis 10 grams, the Radix Astragali 20 grams, Pericarpium Citri Reticulatae 10 grams, Radix Codonopsis 10 grams, Fructus Aurantii 10 grams.Play certain curative effect.
The main still glycerin of Drug therapy of existing market, but the dependency of glycerin is comparatively strong, can not thoroughly effect a radical cure.Although Chinese medicine preparation also has much, effective effect can be played little.
Summary of the invention:
For the present situation of existing treatment puerperal constipation poor effect, the object of the present invention is to provide a kind of Chinese medicine composition being used for the treatment of puerperal constipation, Chinese medicine composition of the present invention is evident in efficacy and have no side effect, improve the resistance against diseases of inside of human body immunologic function enhancing body simultaneously, improve colon microcirculation and colon adjacent organ tissue blood circulation and microcirculation, obtain effect of loosening bowel to relieve constipation, to treatment puerperal constipation, there is certain curative effect.
Specifically, concrete scheme of the present invention is achieved in that
First, inventor provides a kind of Chinese medicine composition being used for the treatment of puerperal constipation according to drug matching experience, and the Chinese medicine ingredients contained in prescription is: Radix Glycyrrhizae, Colla Corii Asini, Aloe, Fructus Lycii, Herba Portulacae, Fructus Cannabis, Semen Astragali Complanati, the Cortex Eucommiae, Radix Achyranthis Bidentatae, the Rhizoma Anemarrhenae, Caulis Polygoni Multiflori, Radix Rhodiolae, Mel, Poria, Herba Cistanches, Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, Herba Leonuri.
Then, inventor provides one according to drug matching experience and controls puerperal constipation prescriptions of Chinese medicine, each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and weight portion are: Radix Glycyrrhizae 3-15 part, Colla Corii Asini 10-30 part, Aloe 20-50 part, Fructus Lycii 12-40 part, Herba Portulacae 10-20 part, Fructus Cannabis 10-30 part, Semen Astragali Complanati 10-25 part, Cortex Eucommiae 8-25 part, Radix Achyranthis Bidentatae 5-15 part, Rhizoma Anemarrhenae 7-26 part, Caulis Polygoni Multiflori 10-30 part, Radix Rhodiolae 10-40 part, Mel 20-50 part, Poria 6-20 part, Herba Cistanches 8-30 part, Cortex Magnoliae Officinalis 10-30 part, Rhizoma Dioscoreae 10-20 part, Herba Leonuri 5-15 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Radix Glycyrrhizae 5-10 part, Colla Corii Asini 15-25 part, Aloe 30-40 part, Fructus Lycii 20-30 part, Herba Portulacae 12-28 part, Fructus Cannabis 20-30 part, Semen Astragali Complanati 15-20 part, Cortex Eucommiae 12-20 part, Radix Achyranthis Bidentatae 10-14 part, Rhizoma Anemarrhenae 10-20 part, Caulis Polygoni Multiflori 15-25 part, Radix Rhodiolae 20-30 part, Mel 30-40 part, Poria 15-20 part, Herba Cistanches 15-25 part, Cortex Magnoliae Officinalis 15-25 part, Rhizoma Dioscoreae 15-20 part, Herba Leonuri 8-12 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, most preferred formula is: 6.5 parts, Radix Glycyrrhizae, 20 parts, Colla Corii Asini, Aloe 35 parts, Fructus Lycii 25 parts, Herba Portulacae 22 parts, Fructus Cannabis 25 parts, Semen Astragali Complanati 18 parts, the Cortex Eucommiae 15.5 parts, Radix Achyranthis Bidentatae 12 parts, the Rhizoma Anemarrhenae 15 parts, Caulis Polygoni Multiflori 20 parts, Radix Rhodiolae 25 parts, Mel 35 parts, 18 parts, Poria, Herba Cistanches 20 parts, Cortex Magnoliae Officinalis 22.5 parts, Rhizoma Dioscoreae 18 parts, Herba Leonuri 10 parts.
In Chinese medicine composition described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, and the dosage of drug used is reasonable, for the effect that treatment puerperal constipation is good after all medicines share.
The function of each taste Chinese crude drug used in the Chinese medicine composition for the treatment of puerperal constipation of the present invention is as follows:
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: GUIXIN, lung, spleen, stomach warp.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Colla Corii Asini: sweet in the mouth, property is put down.
Gui Jing: return lung, liver, kidney channel.
Function cures mainly: YIN nourishing of enriching blood, and moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Aloe: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach, large intestine channel.
Function cures mainly: the dizziness of Liver Channel excess-heat, headache, tinnitus, agitation, constipation, pediatric epilepsy scared, infantile malnutrition, catharsis and toxin expelling.
Fructus Lycii: sweet in the mouth, property is put down.
Gui Jing: return liver, kidney channel.
Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Herba Portulacae: sour in the mouth, cold in nature.
Gui Jing: enter large intestine, liver, spleen channel.
Function cures mainly: heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, pyretic stranguria stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas trace scrofula, for damp and hot caused diarrhoea, dysentery, for oral administrationly control carbuncle, also for having blood in stool, metrorrhagia, have anastalsis.
Fructus Cannabis: sweet in the mouth, property is put down.
Gui Jing: return spleen, stomach, large intestine channel.
Function cures mainly: loosening bowel to relieve constipation.For blood deficiency and depleted fluid, dryness of the intestine constipation.
Semen Astragali Complanati: sweet in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.
The Cortex Eucommiae: sweet in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Achyranthis Bidentatae: bitter in the mouth, property are flat.
Gui Jing: return liver, kidney channel.
Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, and for soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
The Rhizoma Anemarrhenae: bitter in the mouth, cold in nature.
Gui Jing: return lung, stomach, kidney channel.
Function cures mainly: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Caulis Polygoni Multiflori: sweet in the mouth, property is put down
Gui Jing: the heart; Liver Channel
Function cures mainly: tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Main insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus
Radix Rhodiolae: sweet in the mouth, cold in nature.
Gui Jing: lung meridian
Function cures mainly: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness
Mel: sweet in the mouth, property is put down.
Gui Jing: return lung, spleen, large intestine channel.
Function cures mainly: invigorating middle warmer is moisturized, analgesic antidotal.For the empty pain of gastral cavity abdomen, dryness of the lung dry cough, dryness of the intestine constipation; External treatment skin infection is not held back, burn due to hot liquid or fire.
Poria: sweet in the mouth, property are flat.
Gui Jing: GUIXIN, lung, spleen, kidney channel.
Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, and for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Cistanches: sweet in the mouth, warm in nature.
Gui Jing: return kidney, large intestine channel.
Function cures mainly: kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Main kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, temperature.
Gui Jing: return spleen, stomach, lung, large intestine channel.
Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Rhizoma Dioscoreae: sweet in the mouth, property is put down.
Gui Jing: return spleen, lung, kidney channel.
Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, and for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, deficiency-heat is quenched one's thirst, Rhizoma dioscoreae (parched) spleen reinforcing stomach invigorating, loose stool of having loose bowels.
Herba Leonuri: bitter in the mouth, cold in nature.
Gui Jing: return liver, pericardium channel.
Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
The present invention is to above prescription through conscientious research, and according to the reasonability of middle medical drugs, invention proposes concrete a kind of preparation method being used for the treatment of the Chinese medicine composition of puerperal constipation, and concrete steps are:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by itself and step 1) after Chinese medicine slag mixing with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) add mannitol and the lactose of its weight 10% in the mixture of step, add the alcoholic solution of appropriate 5%PVP, granulation drying incapsulates, capsule namely.
Above-mentioned steps 6) described in mannitol and the part by weight of lactose be: 1:1-2.
Described Chinese medicine composition can be used for constipation therapy, is particluarly suitable for the application of puerperal constipation.
The present invention also provides a kind of medical usage of above-mentioned Chinese medicine composition, and namely described Chinese medicine composition prepares puerperal constipation purposes in treatment,
Medicine of the present invention shows outstanding technique effect in animal model experiment, MAREN RUNCHANG WAN and Chinese medicine preparation compositions of the present invention all can significantly improve defecation frequency, relative to model group, there is significant difference (P<0.05), wherein the defecation of Chinese medicine composition object height, middle dosage group is obviously better than MAREN RUNCHANG WAN group, has significant difference (P<0.05).Chinese medicine composition of the present invention has carried out toxicity test, and as can be seen from embodiment 6, Chinese medicine preparation efficacy stability of the present invention, side effect is little.
Chinese medicine composition of the present invention is used for puerperal constipation, compared with prior art has following advantage:
(1) preparation of medicine of the present invention compared with prior art, compatibility is more reasonable, focus on theory of Chinese medical science, negative and positive are balanced, all medicines are mutually arranged in pairs or groups and are reached numerous Chinese medicine and regulate human body comprehensively, from benefiting vital QI and blood, nourishing liver, invigorating kidney to invigorating QI to consolidate the body surface resistance, improve blood circulation, loosening bowel to relieve constipation makes drug effect and function more comprehensive and treating both the principal and secondary aspects of a disease.
(2) in comparing with the Western medicine fat-reducing effect of puerperal constipation, medicine of the present invention is started with from the morbidity root producing constipation, the solution of developing for special crowd is antenatal, puerperal constipation, necessary regulating YIN and YANG, nourishing liver and kidney, nourishing YIN and supplementing blood, the lung moistening and production of body fluid promoting, invigorating brain and relieving mental uneasiness, invigorating the spleen and replenishing QI, loosening bowel to relieve constipation this be the effective way for the treatment of puerpera puerperal constipation, Chinese medicine composition of the present invention can strengthen physical function, the raising of rapid enhancing anemia of pregnant woman immunity in puerperal, can avoid the drug dependence using merely Western medicine to bring.Be better than traditional dietetic therapy or the simple effect using Western medicine.
Specific embodiment
Embodiment 1:
3 grams, Radix Glycyrrhizae, 10 grams, Colla Corii Asini, Aloe 20 grams, Fructus Lycii 12 grams, Herba Portulacae 10 grams, Fructus Cannabis 10 grams, Semen Astragali Complanati 10 grams, the Cortex Eucommiae 8 grams, Radix Achyranthis Bidentatae 5 grams, the Rhizoma Anemarrhenae 7 grams, Caulis Polygoni Multiflori 10 grams, Radix Rhodiolae 10 grams, Mel 20 grams, 6 grams, Poria, Herba Cistanches 8 grams, Cortex Magnoliae Officinalis 10 grams, Rhizoma Dioscoreae 10 grams, Herba Leonuri 5 grams.
Be used for the treatment of a Chinese medicine composition for puerperal constipation, its concrete preparation method is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by after itself and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) weight in grams that adds its weight 10% in the mixture of step is mannitol and the lactose of 1:1, the alcoholic solution adding appropriate 5%PVP is granulated, and dryly also incapsulates, capsule namely.
Embodiment 2
15 grams, Radix Glycyrrhizae, 30 grams, Colla Corii Asini, Aloe 50 grams, Fructus Lycii 40 grams, Herba Portulacae 20 grams, Fructus Cannabis 30 grams, Semen Astragali Complanati 25 grams, the Cortex Eucommiae 25 grams, Radix Achyranthis Bidentatae 15 grams, the Rhizoma Anemarrhenae 26 grams, Caulis Polygoni Multiflori 30 grams, Radix Rhodiolae 40 grams, Mel 50 grams, 20 grams, Poria, Herba Cistanches 30 grams, Cortex Magnoliae Officinalis 30 grams, Rhizoma Dioscoreae 20 grams, Herba Leonuri 15 grams.
Be used for the treatment of a Chinese medicine composition for puerperal constipation, its concrete preparation method is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by after itself and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) weight in grams that adds its weight 10% in the mixture of step is mannitol and the lactose of 1:1.5, the alcoholic solution adding appropriate 5%PVP is granulated, and dryly also incapsulates, capsule namely.
Embodiment 3
5 grams, Radix Glycyrrhizae, 15 grams, Colla Corii Asini, Aloe 30 grams, Fructus Lycii 20 grams, Herba Portulacae 12 grams, Fructus Cannabis 20 grams, Semen Astragali Complanati 15 grams, the Cortex Eucommiae 12 grams, Radix Achyranthis Bidentatae 10 grams, the Rhizoma Anemarrhenae 10 grams, Caulis Polygoni Multiflori 15 grams, Radix Rhodiolae 20 grams, Mel 30 grams, 15 grams, Poria, Herba Cistanches 15 grams, Cortex Magnoliae Officinalis 15 grams, Rhizoma Dioscoreae 15 grams, Herba Leonuri 8 grams.
Be used for the treatment of a Chinese medicine composition for puerperal constipation, its concrete preparation method is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by after itself and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) weight in grams that adds its weight 10% in the mixture of step is mannitol and the lactose of 1:2, the alcoholic solution adding appropriate 5%PVP is granulated, and dryly also incapsulates, capsule namely.
Embodiment 4
10 grams, Radix Glycyrrhizae, 25 grams, Colla Corii Asini, Aloe 40 grams, Fructus Lycii 30 grams, Herba Portulacae 28 grams, Fructus Cannabis 30 grams, Semen Astragali Complanati 20 grams, the Cortex Eucommiae 20 grams, Radix Achyranthis Bidentatae 14 grams, the Rhizoma Anemarrhenae 20 grams, Caulis Polygoni Multiflori 25 grams, Radix Rhodiolae 30 grams, Mel 40 grams, 20 grams, Poria, Herba Cistanches 25 grams, Cortex Magnoliae Officinalis 25 grams, Rhizoma Dioscoreae 20 grams, Herba Leonuri 12 grams.
Be used for the treatment of a Chinese medicine composition for puerperal constipation, its concrete preparation method is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by after itself and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) weight in grams that adds its weight 10% in the mixture of step is mannitol and the lactose of 1:1.5, the alcoholic solution adding appropriate 5%PVP is granulated, and dryly also incapsulates, capsule namely.
Embodiment 5
6.5 grams, Radix Glycyrrhizae, 20 grams, Colla Corii Asini, Aloe 35 grams, Fructus Lycii 25 grams, Herba Portulacae 22 grams, Fructus Cannabis 25 grams, Semen Astragali Complanati 18 grams, the Cortex Eucommiae 15.5 grams, Radix Achyranthis Bidentatae 12 grams, the Rhizoma Anemarrhenae 15 grams, Caulis Polygoni Multiflori 20 grams, Radix Rhodiolae 25 grams, Mel 35 grams, 18 grams, Poria, Herba Cistanches 20 grams, Cortex Magnoliae Officinalis 22.5 grams, Rhizoma Dioscoreae 18 grams, Herba Leonuri 10 grams.
Be used for the treatment of a Chinese medicine composition for puerperal constipation, its concrete preparation method is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by after itself and the mixing of step (1) Chinese medicine slag with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) weight in grams that adds its weight 10% in the mixture of step is mannitol and the lactose of 1:1.5, the alcoholic solution adding appropriate 5%PVP is granulated, and dryly also incapsulates, capsule namely.
Embodiment 6: toxicity is verified
6.1, acute toxicity test
Tested Chinese medicine preparation: the capsule manufactured by embodiment of the present invention 1-5, adds purified water by 1:3.5, makes solution, for subsequent use.
Experimental animal: regular grade kunming mice, body weight 22g ± 5g, male and female half and half, female mice is all without pregnant.
The solution of mouse stomach Chinese medicine capsules preparation of the present invention, when given low reaches 735.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
6.1.1, result of the test shows
The maximum dosage-feeding of the capsule manufactured by mouse stomach embodiment 1-5 is 735.5g crude drug/kg/d (LD50 > 735.5g crude drug/kg).Chinese medicine powder clinical application every day total amount of the present invention is 0.15g crude drug/kg/d to the maximum; By weighing machine, the dosis tolerata of mouse stomach capsule is 4903.3 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
6.2, long-term toxicity test for animals
Tested Chinese medicine preparation: embodiment of the present invention 1-5 gained Chinese medicine capsules, adds purified water by 1:3.5, make solution, for subsequent use.
Experimental animal: regular grade SD rat, body weight 210g ± 14g, male and female half and half, female rats is all without pregnant.
6.2.2, method and result:
Embodiment 1, embodiment 3, embodiment 5 be totally 3 kinds of Chinese medicine capsules: be high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose; Experimental mouse is divided into 10 groups at random, and wherein the capsule solution of 9 groups of difference gavages, 3 kinds of three dosage, remains 1 group of gavage normal saline (40 times of patient's dose); All 10 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
Through long-term feeding, all there is not toxic reaction in 10 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 3 kinds of Chinese medicine capsules show without chronic toxicity animal.
By above two toxicity tests, prove that the present invention is safe by the Chinese medicine capsules that embodiment makes, have no side effect, can be taken by patient.
Embodiment 7: animal model experiment
The pyridine of Semen daturae sulphur benzyl can in the acute and chronic enteritis with slow abdomen rushing down property for the treatment of merit, effectively suppress gastrointestinal motility simultaneously, excessive use causes bowel movement function to reduce, MAREN RUNCHANG WAN is used for the treatment of habitual obstipation, therapeutic effect is better, certain degree can be improved the symptom of constipation, therefore, in the present invention MAREN RUNCHANG WAN is tested as positive control.
7.1, animal model and administration
Animal model: Kunming mouse 50, male and female dual-purpose, body weight 18-22g, raise in advance and conform for 3rd, continuous gavage Semen daturae sulphur benzyl pyridine (2g/kg) seven days, every day 1 time, each treated animal fasting 24h (freely drinking water) on pretreatment, on-test, model group, positive group and invention formulation 3 dosage groups all give compound diphenoxylate by 25mg/kg, and blank group gives equal-volume distilled water.
Administration: mice is divided into 7 groups at random: dosage group (5g/kg), Chinese medicine composition low dose group (2.5g/kg) in Normal group, model group, MAREN RUNCHANG WAN group (mg/kg), Chinese medicine composition high dose group (10g/kg), Chinese medicine composition, often organizes 10; Wherein get the embodiment of the present invention 5 capsule with 10% charcoal end aqueous solution medicinal liquid, as large, medium and small dosage group, the MAREN RUNCHANG WAN charcoal end aqueous solution of 10% is configured to 0.20mg/ml, by 10ml/kg gastric infusion, MAREN RUNCHANG WAN 1.95mg/kg as test positive drug control group, the blank group of charcoal end aqueous solution giving 10% of same volume.
7.2, experimentation and result
Each treated animal fasting 24h (freely drinking water) before experiment, on-test, model group, phenolphthalein group and invention formulation 3 dosage groups all give compound diphenoxylate by 25mg/kg, and blank group gives equal-volume distilled water.After 30min by 10ml/kg give respectively corresponding dosage containing 10% charcoal end drug suspension.After 30min, de-cervical vertebra puts to death animal, open abdominal cavity and be separated mesentery, clip upper end from pylorus, lower end to the intestinal tube of ileocecus, be placed on glass plate, gently small intestinal is pulled into straight line, measuring Length of intestine is " total small intestinal length ", is " prepared Chinese ink propelling length " from pylorus to prepared Chinese ink forward position, ink progradation between calculating group.Result of the test is through statistical procedures, and detailed results is in table 1.
The computational methods of propelling rate are:
Propelling rate=[(distance of charcoal end leading portion and the pylorus)/small intestinal whole audience] × 100%
Table 1 invention formulation is on the impact of mice with constipation intestinal propulsion
Compare with blank group and there is extremely significant difference
##p < 0.01;
Compare with model group and there is significant difference
*p < 0.05,
*p < 0.01;
With MAREN RUNCHANG WAN group ratio, there is significant difference
aMP.AMp.Ampp < 0.05.
From table 1, invention formulation 8.3g, 4.2g/kg dosage group has the effect obviously promoting Constipation Model mouse small intestine wriggling, and there is significant difference (* P < 0.05, * P < 0.01), Chinese medicine composition high dose group of the present invention have compared with MAREN RUNCHANG WAN group significant difference (
*p < 0.05).
Embodiment 8, clinical observation
8.1, physical data
2012-2014 all cases 368 example, all ties up to my institute and gives birth in hospital, and previously stool is normal, and puerperal, constipation occurred.At wherein minimum 18 years old of the age, maximum 42 years old, natural labor 170 example, vagina surgical delivery 110 example, Cesarean esction 88 example, above case was divided into treatment group 184 example at random, matched group 184 example.
8.2, diagnostic criteria
Antenatal stool is normal, and 3-5 days puerperal fell ill, and defecation time extends and reaches 3 days with the last time, and the hard drying of feces, very then in sheep stool shape, can accompany that few abdomen is anxious swollen, god is tired, weak, poor appetite etc.Get rid of organic disease.
8.3, Therapeutic Method
Treatment group is group 1.: 122 examples, and adopt capsule prepared by the embodiment of the present invention 1, once/3, one day three times 7 days was 1 course for the treatment of;
Treatment group is group 2.: 123 examples, adopt capsule prepared by the embodiment of the present invention 5, once/3, one day three times 7 days was 1 course for the treatment of.
Matched group: 123 examples, glycerin 20mL anus injects, and every application in 1 day 1 time, applies 5 times altogether.
8.4, criterion of therapeutical effect
The defecation situation detecting above all cases is carried out after 3 days after drug withdrawal.
Cure: after medication within 2 days defecation once, the soft profit of excrement matter, unobstructed time just, drug withdrawal one week is without recurring;
Effective: after medication within 3 days defecation once, the soft profit of excrement matter, defecation owes unobstructed;
Invalid: take medicine continuously 7 days, symptom is without improvement;
Effective percentage: (recovery from illness+effective)/this group infant sum.
Bounce-back: the individuality recurred again after healing.
8.5, therapeutic effect
Take through two courses for the treatment of continuously, 1. treatment group organizes recovery from illness infant is 54 examples, and effective is 16 examples, invalid 1 example, and treatment group is group 2., individual 62 examples of recovery from illness, effective individual 9 examples, and invalid individuality is 0 example; Observation group's recovery from illness 41 example, effective 18 examples, invalid 12 examples, concrete outcome is in table 2.
The therapeutic effect of table 2 treatment group and matched group compares
| Group | Ill sum | Recovery from illness | Effective | Invalid | Effective percentage (%) | Bounce-back is individual |
| Treat 1. group | 122 | 87 | 33 | 2 | 93.4 | 7 |
| Treat 2. group | 123 | 88 | 34 | 1 | 99.2 | 4 |
| Observation group | 123 | 12 | 58 | 53 | 56.9 | 89 |
8.6, classical case
Case 1: Mrs Qin, female, 36 years old, Shandong Tancheng people, 2012 cesarean institute observe treatment at me, and 4 days periods are stool not, dry during stool, hard, introduce the capsule taking the embodiment of the present invention 5 by doctor, after 3 days, stool better, recover normal, follow up a case by regular visits to and do not recur for 7 days, completely can normal defecation, just matter turns profit, unobstructed during solution.
The above; be only the specific embodiment of the present invention, protection scope of the present invention is not limited thereto, and is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.
Claims (7)
1. one kind is used for the treatment of the Chinese medicine composition of puerperal constipation, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Glycyrrhizae, Colla Corii Asini, Aloe, Fructus Lycii, Herba Portulacae, Fructus Cannabis, Semen Astragali Complanati, the Cortex Eucommiae, Radix Achyranthis Bidentatae, the Rhizoma Anemarrhenae, Caulis Polygoni Multiflori, Radix Rhodiolae, Mel, Poria, Herba Cistanches, Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, Herba Leonuri.
2. a kind of Chinese medicine composition being used for the treatment of puerperal constipation according to claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Glycyrrhizae 3-15 part, Colla Corii Asini 10-30 part, Aloe 20-50 part, Fructus Lycii 12-40 part, Herba Portulacae 10-20 part, Fructus Cannabis 10-30 part, Semen Astragali Complanati 10-25 part, Cortex Eucommiae 8-25 part, Radix Achyranthis Bidentatae 5-15 part, Rhizoma Anemarrhenae 7-26 part, Caulis Polygoni Multiflori 10-30 part, Radix Rhodiolae 10-40 part, Mel 20-50 part, Poria 6-20 part, Herba Cistanches 8-30 part, Cortex Magnoliae Officinalis 10-30 part, Rhizoma Dioscoreae 10-20 part, Herba Leonuri 5-15 part.
3. a kind of Chinese medicine composition being used for the treatment of puerperal constipation according to claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Glycyrrhizae 5-10 part, Colla Corii Asini 15-25 part, Aloe 30-40 part, Fructus Lycii 20-30 part, Herba Portulacae 12-28 part, Fructus Cannabis 20-30 part, Semen Astragali Complanati 15-20 part, Cortex Eucommiae 12-20 part, Radix Achyranthis Bidentatae 10-14 part, Rhizoma Anemarrhenae 10-20 part, Caulis Polygoni Multiflori 15-25 part, Radix Rhodiolae 20-30 part, Mel 30-40 part, Poria 15-20 part, Herba Cistanches 15-25 part, Cortex Magnoliae Officinalis 15-25 part, Rhizoma Dioscoreae 15-20 part, Herba Leonuri 8-12 part.
4. a kind of Chinese medicine composition being used for the treatment of puerperal constipation according to claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: 6.5 parts, Radix Glycyrrhizae, 20 parts, Colla Corii Asini, Aloe 35 parts, Fructus Lycii 25 parts, Herba Portulacae 22 parts, Fructus Cannabis 25 parts, Semen Astragali Complanati 18 parts, the Cortex Eucommiae 15.5 parts, Radix Achyranthis Bidentatae 12 parts, the Rhizoma Anemarrhenae 15 parts, Caulis Polygoni Multiflori 20 parts, Radix Rhodiolae 25 parts, Mel 35 parts, 18 parts, Poria, Herba Cistanches 20 parts, Cortex Magnoliae Officinalis 22.5 parts, Rhizoma Dioscoreae 18 parts, Herba Leonuri 10 parts.
5. prepare a method for the Chinese medicine composition as described in claim 1-4, it is characterized in that, concrete step is:
1) Colla Corii Asini is broken into fine powder and crosses 60-100 mesh sieve, for subsequent use;
2) by Aloe, Semen Astragali Complanati, Herba Portulacae, the Cortex Eucommiae, Cortex Magnoliae Officinalis, Herba Cistanches, Caulis Polygoni Multiflori, Rhizoma Dioscoreae, Radix Rhodiolae and Herba Leonuri remove impurity, 2 times times are decocted with the pure water of 10 times, the boiled 10min of first time intense fire, slow fire 1.5 hours; For the second time, the boiled 5min of intense fire, slow fire 1 hour, merge the filtrate of twice, medicinal residues are for subsequent use;
3) Fructus Cannabis, Poria, Radix Glycyrrhizae pick decontamination, rinse well with water, dry, be placed in hot pot, by the method for frying, slow fire is fried to micro-yellow, is ground into fine powder and crosses 80-100 order and shine, by itself and step 1) after Chinese medicine slag mixing with appropriate 75% ethanol extraction 2 times, each 1 hour, collect extracting solution, leave standstill 24 hours, filter for subsequent use;
4) Fructus Lycii, Radix Achyranthis Bidentatae and the Rhizoma Anemarrhenae add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, leave standstill 24 hours, get supernatant, filter for subsequent use;
5) by step 1) fine powder mix homogeneously with Mel, then add step 2), 3), 4) filtrate stir, decompression recycling ethanol, is concentrated into 75 DEG C, and density is the extractum of 1.10, after drying mixture for subsequent use;
6) to 5) add mannitol and the lactose of its weight 10% in the mixture of step, add the alcoholic solution of appropriate 5%PVP, granulate, drying incapsulates, capsule namely.
6. a kind of preparation method being used for the treatment of the Chinese medicine composition of puerperal constipation according to claim 5, is characterized in that: described step 6) described in mannitol and the part by weight of lactose be: 1:1-2.
7. a kind of Chinese medicine composition being used for the treatment of puerperal constipation according to claim 1, is characterized in that: the application of described Chinese medicine composition in preparation treatment puerperal constipation medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510835523.2A CN105250634A (en) | 2015-11-25 | 2015-11-25 | Traditional Chinese medicine composition for treating postpartum constipation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510835523.2A CN105250634A (en) | 2015-11-25 | 2015-11-25 | Traditional Chinese medicine composition for treating postpartum constipation and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250634A true CN105250634A (en) | 2016-01-20 |
Family
ID=55090762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510835523.2A Pending CN105250634A (en) | 2015-11-25 | 2015-11-25 | Traditional Chinese medicine composition for treating postpartum constipation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250634A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998810A (en) * | 2016-06-27 | 2016-10-12 | 李玲 | Traditional Chinese medicine composition for treating postnatal conspitation |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502599A (en) * | 2009-03-13 | 2009-08-12 | 孙宪悌 | Medicament for treating constipation of old people and postpartum puerpera as well as preparation method |
| CN102698045A (en) * | 2012-06-21 | 2012-10-03 | 武汉长江巨龙药业有限公司 | Chinese medicinal preparation for treating pospartum constipation |
| CN104042981A (en) * | 2014-06-26 | 2014-09-17 | 张士海 | Medicament for treating postnatal constipation and preparation method thereof |
| CN104800568A (en) * | 2015-04-22 | 2015-07-29 | 青岛市市立医院 | Traditional Chinese medicinal capsules used for alleviating postpartum constipation |
-
2015
- 2015-11-25 CN CN201510835523.2A patent/CN105250634A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502599A (en) * | 2009-03-13 | 2009-08-12 | 孙宪悌 | Medicament for treating constipation of old people and postpartum puerpera as well as preparation method |
| CN102698045A (en) * | 2012-06-21 | 2012-10-03 | 武汉长江巨龙药业有限公司 | Chinese medicinal preparation for treating pospartum constipation |
| CN104042981A (en) * | 2014-06-26 | 2014-09-17 | 张士海 | Medicament for treating postnatal constipation and preparation method thereof |
| CN104800568A (en) * | 2015-04-22 | 2015-07-29 | 青岛市市立医院 | Traditional Chinese medicinal capsules used for alleviating postpartum constipation |
Non-Patent Citations (1)
| Title |
|---|
| 崔宇姣,等: "逍遥散加味合穴位按摩治疗产后便秘56例", 《中国临床研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998810A (en) * | 2016-06-27 | 2016-10-12 | 李玲 | Traditional Chinese medicine composition for treating postnatal conspitation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102836409B (en) | Traditional Chinese medicine for treating postpartum lochiorrhea and preparation method | |
| CN104940509A (en) | Application of medicine composition in preparing medicine for treating gynecology hemorrhage syndrome | |
| CN103432559B (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN104958494A (en) | Application of medicinal composition in preparation of medicament for treating gynecological hemorrhage | |
| CN104225215A (en) | Traditional Chinese medicine for treating insomnia | |
| CN104353019A (en) | Traditional Chinese medicine hot compress bag with meridian dredging and internal organ conditioning functions and preparation method of traditional Chinese medicine hot compress bag | |
| CN102988733A (en) | Traditional Chinese medicine composition for treating postpartum hypogalactia and preparation method thereof | |
| CN103071105B (en) | External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof | |
| CN104524071A (en) | Pharmaceutical composition for treating primary renal disease and application thereof | |
| CN105213807A (en) | Be used for the treatment of the medicine of type of hyperactivity of fire caused by deficiency of YIN recurrent oral ulceration | |
| CN105031013A (en) | Medicine for treating lumbar vertebrae bone hyperplasia and preparation method thereof | |
| CN105194338A (en) | Traditional Chinese medicine composition for treating uterus cold and preparation method thereof | |
| CN103157062A (en) | Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof | |
| CN103735792B (en) | A kind of medicine for the treatment of menoxenia and preparation method thereof | |
| CN105250634A (en) | Traditional Chinese medicine composition for treating postpartum constipation and application thereof | |
| CN105770691A (en) | Medicinal preparation for treating cervical cancer and application thereof | |
| CN105362647A (en) | Method for preparing pharmaceutical composition for treating gynecological hemorrhage syndrome | |
| CN105267630A (en) | Traditional Chinese medicine for treating tinnitus | |
| CN103800561A (en) | Traditional Chinese medicine for treating renal hematuria | |
| CN103041194B (en) | Traditional Chinese medicine composition for curing chronic eczema and preparation method thereof | |
| CN106177857A (en) | A kind of medicine treating habitual abortion and preparation method thereof | |
| CN104800568A (en) | Traditional Chinese medicinal capsules used for alleviating postpartum constipation | |
| CN105727237A (en) | Folium artemisiae argyi-containing pharmaceutical composition for treating amenorrhea | |
| CN105267895A (en) | Medicine for treating bovine postpartum blood stasis type placenta retension and preparing method thereof | |
| CN105327299A (en) | Medicine for treating idiopathic thrombocytopenic purpura |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |
|
| RJ01 | Rejection of invention patent application after publication |