CN105031673A - Traditional Chinese medicine imaging assisting agent for stomach B ultrasonic examination and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine imaging assisting agent for stomach B ultrasonic examination and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: mandarin orange seed, leaf of gordon Euryale, crystalline mirabilite, coral skeleton, leaf of velutinous cinquefoil, root of romanet grape, old radish root, common adenostema herb, cablin potchouli herb, boor mustard herb, pear leaf, fruit-spike of betel pepper, rose, twotooth achyranthes root, all-grass of Chinese penthorum, heterophylly faalsestarwort root, herb or root of fourleaf peperomia and towel gourd vegetable sponge. The traditional Chinese medicine imaging assisting agent for stomach B ultrasonic examination, provided by the invention, has the beneficial effects of being safe and convenient to use, avoiding pains and toxic effects, being short in examination time and high in imaging rate and providing a strong basis for clinical diagnosis of diseases, so that the traditional Chinese medicine imaging assisting agent is a relatively ideal novel imaging assisting agent; and moreover, the preparation process is simple and practical.

Description

A kind of stomach ultrasound diagnosis Chinese medicine contrast agent and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of stomach ultrasound diagnosis Chinese medicine contrast agent and preparation method thereof.

Background technology

Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three to act on greatly to material: one is mechanism, because ultrasonic energy is huge, often makes material particle do altofrequency mechanical vibration, thus produce smash, condense, agitation effects.Two is warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature raise phenomenon.Three is cavitations, when ul-trasonic irradiation is on liquid, become sparse in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure great variety, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.This cavity time of staying is not long, collapses again under huge acoustic pressure effect, and formed due to cavity and disappear, producing a large amount of bubble will affect ultrasonic diagnosis effect, so, eliminate the Main Function that bubble is ultrasonic contrast agent.

At present, for B ultrasonic gastrointestinal contrast agent, prior art describes the contrast agent be mixed with by the 100 order fine powders of Fructus Pratiae Begonifoliae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, to gastrointestinal disease, there is convergence, antacid effect, but weak point is patient take contrast agent after to produce strong echo luminous point not enough, reflecting effect is not good, and the display of coat of the stomach level is unintelligible; After patient takes this contrast agent, gastric acid strong reaction, has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not applies this contrast agent to gastrorrhagia patient.

Another kind of fast ultrasonic image-developing liquor preparation method is that make imaging liquid, excellent video picture rate reaches 87% through decocting, distilling, concentrate after bitter bucket, MIXIANG, abdomen floss, Herba vallisneriae Spiralis, Radix Glycyrrhizae, sucrose being mixed in proportion.Used bitter bucket in this prescription, taste is extremely bitter, thus improves mouthfeel with sucrose, and sucrose enters in gastric juice and easily produces bubble, thus has impact to imaging results, and in addition, this invention product is without therapeutical effect.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of use safety, shortens the review time, improves stomach ultrasound diagnosis Chinese medicine contrast agent and preparation method thereof of video picture rate.

In order to solve the problems of the technologies described above, the invention provides a kind of stomach ultrasound diagnosis Chinese medicine contrast agent, described Chinese medicine contrast agent comprises following raw medicinal material: Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani, Herba Adenostemmatis, Herba Pogostemonis, Herba Thlaspis, Folium pyri, Spica piperis betlis, Flos Rosae Rugosae, Radix Achyranthis Bidentatae, Herba Penthori chinensis, Radix Pseudostellariae, Herba Seu Radix Peperomiae Tetraphyllae and Retinervus Luffae Fructus.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent can be preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 20 parts, Folium Euryales 12 ~ 22 parts, Mirabilitum crystallina 20 ~ 30 parts, Bal(n)phyllia sp. 14 ~ 24 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 ~ 20 parts, Radix vitis romanetii 20 ~ 30 parts, Radix Raphani 15 ~ 25 parts, Herba Adenostemmatis 20 ~ 30 parts, Herba Pogostemonis 8 ~ 18 parts, Herba Thlaspis 10 ~ 20 parts, Folium pyri 20 ~ 30 parts, Spica piperis betlis 25 ~ 35 parts, Flos Rosae Rugosae 12 ~ 22 parts, Radix Achyranthis Bidentatae 20 ~ 30 parts, Herba Penthori chinensis 15 ~ 25 parts, Radix Pseudostellariae 20 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 10 ~ 20 parts and Retinervus Luffae Fructus 22 ~ 32 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent can also more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 15 parts, Folium Euryales 13 ~ 18 parts, Mirabilitum crystallina 22 ~ 27 parts, Bal(n)phyllia sp. 16 ~ 21 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 15 ~ 20 parts, Radix vitis romanetii 23 ~ 28 parts, Radix Raphani 18 ~ 23 parts, Herba Adenostemmatis 25 ~ 30 parts, Herba Pogostemonis 10 ~ 15 parts, Herba Thlaspis 13 ~ 18 parts, Folium pyri 22 ~ 26 parts, Spica piperis betlis 28 ~ 33 parts, Flos Rosae Rugosae 14 ~ 19 parts, Radix Achyranthis Bidentatae 22 ~ 26 parts, Herba Penthori chinensis 17 ~ 22 parts, Radix Pseudostellariae 25 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 13 ~ 18 parts and Retinervus Luffae Fructus 24 ~ 29 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent also can more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 14 parts, Folium Euryales 15 parts, Mirabilitum crystallina 26 parts, Bal(n)phyllia sp. 17 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 18 parts, Radix vitis romanetii 25 parts, Radix Raphani 22 parts, Herba Adenostemmatis 26 parts, Herba Pogostemonis 14 parts of, Herba Thlaspiss 15 parts, Folium pyri 25 Fen, Spica piperis betlis 29 parts, Flos Rosae Rugosae 18 parts, Radix Achyranthis Bidentatae 24 parts, Herba Penthori chinensis 21 parts, Radix Pseudostellariae 26 parts, Herba Seu Radix Peperomiae Tetraphyllae 16 parts and Retinervus Luffae Fructus 25 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent also can more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 12 parts, Folium Euryales 16 parts, Mirabilitum crystallina 24 parts, Bal(n)phyllia sp. 20 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 16 parts, Radix vitis romanetii 28 parts, Radix Raphani 20 parts, Herba Adenostemmatis 30 parts, Herba Pogostemonis 12 parts of, Herba Thlaspiss 16 parts, Folium pyri 22 Fen, Spica piperis betlis 32 parts, Flos Rosae Rugosae 15 parts, Radix Achyranthis Bidentatae 25 parts, Herba Penthori chinensis 18 parts, Radix Pseudostellariae 28 parts, Herba Seu Radix Peperomiae Tetraphyllae 14 parts and Retinervus Luffae Fructus 27 parts.

When the dosage form of described Chinese medicine contrast agent is oral solutions, its preparation method comprises the following steps:

The first step, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani and Herba Adenostemmatis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of described Chinese medicine contrast agent is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

Beneficial effect of the present invention: stomach ultrasound diagnosis Chinese medicine contrast agent of the present invention is safe and convenient to use, no pain, free of toxic effects, review time is short, and video picture rate is high, and the clinical diagnosis for disease provides strong foundation, be ideal novel contrast agent, and preparation technology is simple, practical.

Detailed description of the invention

The invention provides a kind of stomach ultrasound diagnosis Chinese medicine contrast agent, described Chinese medicine contrast agent comprises following raw medicinal material: Rhizoma valerianae latifoliae, Flos Rosae Rugosae floral leaf, Juncus amplifolius A. Camus, Radix Aristolochiae yunnanensis, Fructus Pratiae Begonifoliae, Herba vallisneriae Spiralis, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani, Herba Adenostemmatis, Herba Pogostemonis, Herba Thlaspis, Folium pyri, Spica piperis betlis, Flos Rosae Rugosae, Radix Achyranthis Bidentatae, Herba Penthori chinensis, Radix Pseudostellariae, Herba Seu Radix Peperomiae Tetraphyllae and Retinervus Luffae Fructus.

The pharmacology of various raw medicinal material is as follows:

Citrus chachiensis Hort. (C．Suavissima Tanaka): [source] medical material Ji Yuan: be the seed of the multiple Citrus chachiensis Hort. classes such as rutaceae Citrus reticulata Blanco cv. Chachiensis.Latin plant animal mineral name: CitruschachiensisHort.[nature and flavor] are bitter; Pungent; Temperature.[return through] heart; Liver.The pain relieving of [function cures mainly] the kidney warming; Promoting QI to circulate and dispersing the agglomeration of the pathogens.Main lumbago; Colicky pain of bladder; Inguinal hernia; The testis swelling and hanging down of either of the testes swells and ache.[extracts] " China's book on Chinese herbal medicine "

Folium Euryales: [another name] Caput Gallus domesticus dish, Ci Heye.[source] medical material Ji Yuan: be the leaf of nymphaeaceae plant Gorgon euryale EuryaleferoxSalisb..[nature and flavor] are bitter; Pungent; Flat.[return through] liver; Kidney channel.[function cures mainly] promoting flow of QI and blood; Hemostasis by removing blood stasis.Main haematemesis; Have blood in stool; Women's retention of placenta in puerperal.[extracts] " China's book on Chinese herbal medicine "

Mirabilitum crystallina: [another name] Mirabilitum crystallina, plain boiled water stone, CALCITUM GYPSUM RUBRUM, salt essence, water stone, BINGSHI, magpie stone, salt essence stone, mud essence, salt pillow, salt root.[source] medical material Ji Yuan: for Sulfates Gypsum Fibrosum race's mineral gypsum or be carbonate calcite race mineral calcite.[nature and flavor] are pungent salty; Cold.[return through] heart; Stomach; Kidney channel.[function cures mainly] resolving heat and reducing pathogenic fire; Profit key; Detumescence.Row calentura time main; High fever excessive thirst; Laryngopharynx swelling and pain; Edema; Urine retention; Aphtha of the mouth and tongue; Carbuncle; Erysipelas; Scald.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Bal(n)phyllia sp.: [another name] Bal(n)phyllia sp., Zhong-Ru E Guan Shi.[source] medical material Ji Yuan: be the thin tube-like aggregation of carbonate calcite race mineral calcite.Latin plant animal mineral name: Stalactite.[nature and flavor] are sweet; Salty; Temperature; Nontoxic.[return through] lung; Kidney; Stomach warp.[function cures mainly] warming the lung; Tonifying YANG; Lactogenesis.Main lung cold chronic cough; Asthenia cough with asthma; Impotence and premature ejaculation; Emission; Cold arthralgia of loins and legs; Galactostasis.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Folium potentillae velutinae (Radix Potentillae Fulgentis): [another name] little Herba potentillae fulgentis, land for building wind, little reddish black.[source] medical material Ji Yuan: be the root of rosaceous plant velutinous cinquefoil.Latin plant animal mineral name: PotentillagriffithiiHook.f.var.velutinaCard.[nature and flavor] are puckery; Micro-hardship; Flat.[return through] stomach, liver, large intestine channel.[function cures mainly] promote qi circulation digestion promoting, astringing to arrest bleeding, heat clearing and blood circulation promoting.The long-pending stomachache of staple food, gastric and duodenal ulcers, infantile malnutrition, dysentery, puerperal hemorrhage is too much, infantile convulsion, facial paralysis.[extracts] " China's book on Chinese herbal medicine "

Radix vitis romanetii: [another name] Vitis davidi, Radix Stephaniae Japonicae, Vitis Amurensis.[source] medical material Ji Yuan: be the root of vitaceae net arteries and veins Fructus Vitis viniferae.Latin plant animal mineral name: VitiswilonaeVeitch [VitisreticulataGagnep.].[nature and flavor] are sweet; Flat; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing.Main carbuncle furuncle; Chronic osteomyelitis.[extracts] " China's book on Chinese herbal medicine "

Radix Raphani: [another name] celestial being bone, go out Radix Raphani, Lao Bu head, Lao Rentou, withered trailing plants, raphani,radix, dry old Raphanus sativus L., empty Lay clothes, old Radix Raphani.[source] medical material Ji Yuan: for crucifer Lay takes the old root that blossoms and bears fruit.Latin plant animal mineral name: RaphanussativusL.[nature and flavor] are sweet; Pungent; Flat.[return through] lung; Kidney channel.[function cures mainly] circulation of qi promoting removing food stagnancy, reduces phlegm, quenches one's thirst, inducing diuresis to remove edema.Main cough with copious phlegm; Stagnation of QI due to dyspepsia; Abdominal distention feeling of fullness; Dysentery; Quench one's thirst; Beriberi, edema.[extracts] " China's book on Chinese herbal medicine "

Herba Adenostemmatis: [another name] core Spina Gleditsiae, acute mastitis medicine, Radix Alangii.[source] medical material Ji Yuan: be the herb of feverfew adenostemma laveniaKuntze.Latin plant animal mineral name: Adenostemmalauenia (L.) O.Kuntze.[nature and flavor] acrid in the mouth; Micro-hardship; Property is shied.[function cures mainly] heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main cold, fever; Icterohepatitis; Cough due to lung-heat; Laryngopharynx swelling and pain; Beriberoid pyretic arthralgia; Acute mastitis; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Pogostemonis: [another name] Herba Pogostemonis, extra large Herba Pogostemonis.[source] medical material Ji Yuan: be the herb of labiate Herba Pogostemonis.[nature and flavor] acrid in the mouth; Slightly warm in nature.[return through] returns spleen; Stomach; Lung meridian.[function cures mainly] removing dampness by means of aromatics; Stomach function regulating preventing or arresting vomiting; Dispelling summer-heat from superficies of the body.Gastral cavity abdomen painful abdominal mass Min of main retention of dampness in middle-JIAO; Inappetence; Vomiting; Have loose bowels; The cold and heat headache of diseases caused by exogenous pathogenic factor heat-damp in summer; Hygropyrexia from the beginning of heating body be stranded; Feel sick in breast Min; Nasal sinusitis; Tinea manus and pedis.[extracts] " China's book on Chinese herbal medicine "

Herba Thlaspis: [another name] large shepherd's purse, slight Xi, large Ji, Ma Xin, analyse order, flourish order, colt, old shepherd's purse, Guo Pu's note, Thalaspi arvense L., floral leaf shepherd's purse, water shepherd's purse, Lao Gucao, Semen Benincasae are careless, HERBA THALASPIS.[source] medical material Ji Yuan: be the herb of crucifer Herba Thlaspis.Latin plant animal mineral name: ThlaspiarvenseL.[nature and flavor] are bitter; Sweet; Be slightly cold.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.Main conjunctival congestion and swelling pain; Lung abscess; Intestinal carbuncle; Have loose bowels; Dysentery; Leucorrhea; Postnatal blood stasis is suffered from abdominal pain; Dyspepsia; Oedema due to nephritis; Cirrhotic ascites; Carbuncle pyogenic infections from tumour or sore.[extracts] " China's book on Chinese herbal medicine "

Folium pyri: [source] medical material Ji Yuan: be the leaf of medicine rosaceous plant Pyrus bretschneideri, Nashi Pear or Pyrus ussuriensis Maxim etc.[nature and flavor] are bitter, puckery, Xin Liang.[return through] lung; Spleen; Urinary bladder channel.[function cures mainly] soothing liver-QI stomach function regulating, promoting diuresis to remove toxic substance.Main cholera is vomited and diarrhoea and is suffered from abdominal pain, and edema, dysuria, infantile hernia, mushroom is poisoning.[extracts] " China's book on Chinese herbal medicine "

Spica piperis betlis: [English name] Fruit-spikeofBetelPepper.[another name] Spica piperis betlis, Betel, native Fructus Piperis Longi, large Fructus Piperis Longi, Betel green grass or young crops, Bin Lang Betel, green grass or young crops wither, Spica piperis betlis, greatly Spica piperis betlis, Qing Betel, Herba Penthori chinensis beach wormwood.[source] medical material Ji Yuan: for medicine Piperaceae plants the fruit ear of thing Spica piperis betlis.[nature and flavor] are pungent; Temperature.[return through] lung; Spleen channel.[function cures mainly] warming the middle warmer and descending qi, vanishing sputum and dispelling knot, pain relieving.Main institute abdomen cold type of pain, vomiting is had loose bowels, abdominal pain due to worm stagnation, cough with dyspnea, toothache.[extracts] " China's book on Chinese herbal medicine "

Flos Rosae Rugosae: [another name] hover flower, nib flower, lake flower, Flos Rosae Davuricae, thorn rose chrysanthemum.[source] medical material Ji Yuan: be the flower of rosaceous plant Flos Rosae Rugosae and polyphyll Flos Rosae Rugosae.[nature and flavor] are sweet; Micro-hardship; Temperature; Nontoxic.[return through] liver; Spleen channel.[function cures mainly] regulates the flow of vital energy resolving depression; Regulating menstruation by adjusting the flow of blood.Chest and diaphragm caused by main depression of liver-QI is full vexed, and gastral cavity side of body distending pain, breast is done swollen, menoxenia, and dysentery is had loose bowels, leukorrhagia, traumatic injury carbuncle.[extracts] " China's book on Chinese herbal medicine "

Radix Achyranthis Bidentatae: [another name] Radix Achyranthis Bidentatae, cattle stem, foot this pedal, car pusher knee joint, Du's Radix Achyranthis Bidentatae, Radix Achyranthis Bidentatae, bosom sunset, true sunset, bosom knee joint, Radix Achyranthis, Radix Achyranthis Bidentatae, Red Radix Achyranthis Bidentatae, cattle knock knee joint, cattle gram knee joint, cattle lid knee joint, stickweed daughter root, cattle arm knee, wild ox fill knee joint, Cortex torricelliae tiliifoliae, cattle lid knees.[source] medical material Ji Yuan: be the root of amaranthaceous plant Radix Achyranthis Bidentatae.Latin plant animal mineral name: AchyranthesbidentataBl.[nature and flavor] are bitter; Acid; Property is put down.[return through] liver; Kidney channel.[function cures mainly] invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite descending; Inducing diuresis for treating stranguria syndrome.Main soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Levy abdominal mass; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "

Herba Penthori chinensis: [another name] Herba Lysimachiae Clethroids, water dregs indigo plant, Radix Homonoiae Ripariae, Penthorum chinense, red building are believed, tuberculosis of bone and joint grass, Monas cuspurpureus Went are careless, water Fructus Persicae grass, two-wire are careless, water Herba Amaranthi tricoloris grass.[source] medical material Ji Yuan: be the herb of brave Er Yeke plant Herba Lysimachiae Clethroids.Latin plant animal mineral name: PenthorumchinensePursh [P.sedoidesL.var.chinense (Pursh) Maxim.].[nature and flavor] bitter in the mouth, micro-pungent, cold in nature.[return through] liver; Kidney channel.[function cures mainly] diuretic dehumidifies, promoting blood circulation to remove blood stasis, hemostasis, removing toxic substances.Main edema, dysuria, jaundice, leukorrhagia, dysentery, amenorrhea, traumatic injury, hematuria, metrorrhagia, venom.[extracts] " China's book on Chinese herbal medicine "

Radix Pseudostellariae: [another name] Radix Ginseng, Tong Can, two batches seven, Radix Codonopsis Lanceolatae, meter Can.[source] is the tuber of pinkwort Radix Ginseng.[nature and flavor] are sweet; Micro-hardship; Cold nature.[return through] spleen, lung meridian.[function cures mainly] mends strengthening spleen and lung; Supplementing QI for promoting the production of body fluid.Main weakness of the spleen and stomach; Inappetence; Lassitude; Impairment of both QI and YIN; Dry cough expectorant is few; Spontaneous perspiration is breathed hard; And the convalescent stage of febrile disease deficiency of vital energy Tianjin wound; Interior-heat is thirsty; Or neurasthenia, palpitation and insomnia, dizzy forgetful, Infantile Summer Fever.[extracts] " China's book on Chinese herbal medicine "

Herba Seu Radix Peperomiae Tetraphyllae: [another name] Semen Sojae Preparatum Herba Pyrolae, rock muscle grass, Semen Sojae Preparatum Viola arcuata, Semen Benincasae deer rank, Semen Benincasae Herba Asari, Herba Sedi tetractini, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Moghania fluminalis(C. B. Clarke) Li lobe, Semen Sojae Preparatum grass, roundleaf Semen Benincasae dish, stone is revived after death, rock is spent, stone on watt slurry, Herba Anotis ingratae, 3 years grass.[source] medical material Ji Yuan: be the herb of Piperaceae plant Herba Seu Radix Peperomiae Tetraphyllae or hair YEDOU lobe.[nature and flavor] are pungent; Bitter; Tepor.[return through] lung; Liver; Spleen channel.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Expelling wind and removing dampness; Preventing phlegm from forming and stopping coughing.Main bones and muscles pain due to rheumatism; Traumatic injury; Furuncle toxic swelling; Pharyngolaryngitis; Stomatitis; Dysentery; Watery diarrhea; Dyspepsia does not disappear; Infantile malnutrition; Epersalgia cough; Asthma; Pertussis.[extracts] " China's book on Chinese herbal medicine "

Retinervus Luffae Fructus: [another name] sky trailing plants muscle, Fructus Luffae net, Fructus Luffae shell, melon network, wadding melon pulp, sky sieve line, vegetable sponge, chalina, Hypericum perforatum L., Fructus Luffae cloth.[source] medical material Ji Yuan: be the vascular bundle of cucurbitaceous plant Fructus Luffae or Fructus Luffae mature fruit difficult to understand.[nature and flavor] bitter in the mouth; Cool in nature.[return through] returns lung; Liver; Stomach warp.[function cures mainly] dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture is coughed, carbuncle future sore, his carbuncle.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent can be preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 20 parts, Folium Euryales 12 ~ 22 parts, Mirabilitum crystallina 20 ~ 30 parts, Bal(n)phyllia sp. 14 ~ 24 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 ~ 20 parts, Radix vitis romanetii 20 ~ 30 parts, Radix Raphani 15 ~ 25 parts, Herba Adenostemmatis 20 ~ 30 parts, Herba Pogostemonis 8 ~ 18 parts, Herba Thlaspis 10 ~ 20 parts, Folium pyri 20 ~ 30 parts, Spica piperis betlis 25 ~ 35 parts, Flos Rosae Rugosae 12 ~ 22 parts, Radix Achyranthis Bidentatae 20 ~ 30 parts, Herba Penthori chinensis 15 ~ 25 parts, Radix Pseudostellariae 20 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 10 ~ 20 parts and Retinervus Luffae Fructus 22 ~ 32 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent can also more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 15 parts, Folium Euryales 13 ~ 18 parts, Mirabilitum crystallina 22 ~ 27 parts, Bal(n)phyllia sp. 16 ~ 21 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 15 ~ 20 parts, Radix vitis romanetii 23 ~ 28 parts, Radix Raphani 18 ~ 23 parts, Herba Adenostemmatis 25 ~ 30 parts, Herba Pogostemonis 10 ~ 15 parts, Herba Thlaspis 13 ~ 18 parts, Folium pyri 22 ~ 26 parts, Spica piperis betlis 28 ~ 33 parts, Flos Rosae Rugosae 14 ~ 19 parts, Radix Achyranthis Bidentatae 22 ~ 26 parts, Herba Penthori chinensis 17 ~ 22 parts, Radix Pseudostellariae 25 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 13 ~ 18 parts and Retinervus Luffae Fructus 24 ~ 29 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent also can more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 14 parts, Folium Euryales 15 parts, Mirabilitum crystallina 26 parts, Bal(n)phyllia sp. 17 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 18 parts, Radix vitis romanetii 25 parts, Radix Raphani 22 parts, Herba Adenostemmatis 26 parts, Herba Pogostemonis 14 parts of, Herba Thlaspiss 15 parts, Folium pyri 25 Fen, Spica piperis betlis 29 parts, Flos Rosae Rugosae 18 parts, Radix Achyranthis Bidentatae 24 parts, Herba Penthori chinensis 21 parts, Radix Pseudostellariae 26 parts, Herba Seu Radix Peperomiae Tetraphyllae 16 parts and Retinervus Luffae Fructus 25 parts.

The ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent also can more preferably: Citrus chachiensis Hort. (C．Suavissima Tanaka) 12 parts, Folium Euryales 16 parts, Mirabilitum crystallina 24 parts, Bal(n)phyllia sp. 20 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 16 parts, Radix vitis romanetii 28 parts, Radix Raphani 20 parts, Herba Adenostemmatis 30 parts, Herba Pogostemonis 12 parts of, Herba Thlaspiss 16 parts, Folium pyri 22 Fen, Spica piperis betlis 32 parts, Flos Rosae Rugosae 15 parts, Radix Achyranthis Bidentatae 25 parts, Herba Penthori chinensis 18 parts, Radix Pseudostellariae 28 parts, Herba Seu Radix Peperomiae Tetraphyllae 14 parts and Retinervus Luffae Fructus 27 parts.

The present invention further provides again a kind of preparation method of above-mentioned stomach ultrasound diagnosis Chinese medicine contrast agent, and the dosage form of described Chinese medicine contrast agent is oral solutions, and it comprises the following steps:

The first step, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani and Herba Adenostemmatis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

The present invention still further provides a kind of preparation method of above-mentioned stomach ultrasound diagnosis Chinese medicine contrast agent, and the dosage form of described Chinese medicine contrast agent is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: oral solutions

Get Citrus chachiensis Hort. (C．Suavissima Tanaka) 120g, Folium Euryales 160g, Mirabilitum crystallina 240g, Bal(n)phyllia sp. 200g, Folium potentillae velutinae (Radix Potentillae Fulgentis) 160g, Radix vitis romanetii 280g, Radix Raphani 200g, Herba Adenostemmatis 300g, Herba Pogostemonis 120g, Herba Thlaspis 160g, Folium pyri 220g, Spica piperis betlis 320g, Flos Rosae Rugosae 150g, Radix Achyranthis Bidentatae 250g, Herba Penthori chinensis 180g, Radix Pseudostellariae 280g, Herba Seu Radix Peperomiae Tetraphyllae 140g and Retinervus Luffae Fructus 270g;

Its preparation method comprises the following steps:

The first step, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani and Herba Adenostemmatis are mixed, add relative to mixture 4 times amount determining alcohol be 65% alcohol reflux 2 times, each 2.5 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3.5 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 36 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Embodiment 2: powder

Get Citrus chachiensis Hort. (C．Suavissima Tanaka) 140g, Folium Euryales 150g, Mirabilitum crystallina 260g, Bal(n)phyllia sp. 170g, Folium potentillae velutinae (Radix Potentillae Fulgentis) 180g, Radix vitis romanetii 250g, Radix Raphani 220g, Herba Adenostemmatis 260g, Herba Pogostemonis 140g, Herba Thlaspis 150g, Folium pyri 250g, Spica piperis betlis 290g, Flos Rosae Rugosae 180g, Radix Achyranthis Bidentatae 240g, Herba Penthori chinensis 210g, Radix Pseudostellariae 260g, Herba Seu Radix Peperomiae Tetraphyllae 160g and Retinervus Luffae Fructus 250g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 10 hours, with slow fire boiling, decocting time is 3.5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second filtrate, and the quality of the water added is 2.5 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, and by the material pouch after mixing or packing box subpackage, every 10 grams is one bag or a box subpackage.

Acute toxicity test: be dissolved in distilled water with oral solutions prepared by the embodiment of the present invention 1, gives (often organizing 15) the feeding dispensing of 4 groups of white mice or wiping respectively with 80 of clinical consumption per day times, 120 times, 150 times and 230 times, observes 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test: the oral solutions embodiment of the present invention 1 prepared is by 16.25, 31.47 and 63.19g crude drug/kg be dissolved in water, continuous use 16 weeks are distinguished to 3 groups of mices (often organizing 20), every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of 3 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Pharmacological experiment illustrates:

Pharmacodynamic experiment

One, the oral solutions of Chinese medicine contrast agent of the present invention impact that small intestine movement of mice is moved

1, test material:

1.1 experimental animals: by medical college biological study room, Shandong ICR mice 100, male and female half and half, body weight 20 ~ 28g.

1.2 trial drugs:

1.2.1 the oral solutions of Chinese medicine contrast agent of the present invention.Chinese medicine contrast agent oral solutions distilled water of the present invention is dissolved into 0.467,0.233, the medicinal liquid of 0.117g crude drug/ml is stand-by.

1.2.2 atropine sulfate injection (Sui Cheng Pharmaceutical limited company, H41021256), uses front normal saline dilution to become 0.01mg/ml solution.

1.2.3 active carbon; Arabic gum (making containing 10% Radix Acaciae senegalis, the charcoal end distilled water suspension of 5% active carbon).

1.3 testing equipments: YP610 electronic analytical balance (Shanghai head of the horse, precision 0.01g), YP200 electronic analytical balance (Shanghai head of the horse, precision 0.001g).

2, test method:

Select 20 ~ 28g body weight mice, be divided into 5 groups by the method for body weight random stratified, be i.e. blank group, positive drug (atropine) group, the high, medium and low dosage group of extract oral liquor of the present invention.Often organize 20, male and female half and half.Blank group and atropine group gavage distilled water 30ml/kg, the other gavage of high, medium and low dosage component extract oral liquor of the present invention medicinal liquid 14,7,3.5g crude drug/kg, 1 time/d.Gavage is after 7 days, can't help water 18h in the experiment the previous day of fasting at dusk, and after the 8th day last administration 1h (atropine diluent 0.1mg/kg5min), each group gavage charcoal end suspension 0.2ml/ only.Animal is put to death after 20min; open abdominal cavity and be separated mesentery; see that coat of the stomach clear layer is visible, and this contrast agent takes down, stomach week mucosa is played a protective role; ultrasound display screen can be seen place's video pictures such as gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature obvious; each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display clear, clip front end is to pylorus; rear end, to the intestinal tube of ileocecus, is placed on pallet.Gently small intestinal is put into straight line, measures Length of intestine as " total small intestinal length ".From pylorus to the distance in prepared Chinese ink forward position as " distance that prepared Chinese ink advances at enteral ".Formulae discovery ink progradation: ink progradation=(prepared Chinese ink is in enteral advance distance/small intestinal total length) × 100%.

3, result of the test:

Compare with matched group, positive drug atropine group charcoal end delaunay triangle rate obviously reduces (P<0.05), and the gastric peristalsis of extract oral liquor of the present invention is obviously hyperfunction, compares with model control group, can obviously promote gastrointestinal motility function.In table 1.

Table 1 oral solutions of the present invention is on the impact of the hyperfunction mouse small intestine motion of intestinal propulsion:

Group	Number of cases	Delaunay triangle rate %
			Normal group	20	40.28±2.54
Positive drug atropine group	20	58.32±7.16
			Oral solutions 3.5g crude drug/kg of the present invention	20	66.15±9.28
Oral solutions 7g crude drug/kg of the present invention	20	74.82±8.63
			Oral solutions 14g crude drug/kg of the present invention	20	85.26±7.52

Conclusion (of pressure testing): the oral solutions 3.5g/kg of Chinese medicine contrast agent of the present invention has obvious inhibitory action to the motion of gastrointestinal motility hyperfunctioning mouse small intestine, increases, show the trend promoting bowel movement effect with dosage.This test is from the oral solutions treatment gastropathy that have studied Chinese medicine contrast agent of the present invention in body and the impact of in vitro function of intestinal canal, stopping leak, antibacterial, the anti-immunity of antiinflammatory etc., the Pharmacological Mechanism of enteritis, dysentery, gastrointestinal motility can be promoted, digestion, absorption, and have certain bacteriostasis, and show the anti-immunization of stronger antiinflammatory.

Two, In vitro Bactericidal Experiments

Double broth dilution method is adopted to measure the minimum inhibitory concentration (MIC) of the present invention to common pathogen.Be inoculated in by tested bacterium in MH broth bouillon, cultivate after 18 hours for 35 DEG C, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 10 ⁸cFU/ml.With physiological saline solution dilution 1: 10 (bacteria containing amount about 10 ⁷cFU/ml).Get the medicinal liquid 2ml diluted for series concentration respectively to add and perform in the flat board of labelling, then the MH agar culture medium 18ml being chilled to about 50 DEG C after getting thawing be added to dull and stereotyped in (medicine: agar=1: 9) makes medicine and culture medium fully mix.Medicine ultimate density is respectively 200mg/ml, 100mg/ml, 50mg/ml, 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.13mg/ml, 1.56mg/ml, 0.78mg/ml and 0.39mg/ml.Be inoculated on pastille flat board by the bacteria suspension inoculating loop prepared, cultivate 18 hours observed results in 35 DEG C, the lowest concentration of drug that colony growth is totally constrained is that this medicine is to the MIC detecting bacterium.Single bacteria growing can be ignored.Drug control and strain growth contrast are established in test simultaneously.The results are shown in Table 2.

Table 2 extracorporeal bacteria inhibitor test result:

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Shigella flexneri	5.126
Paratyphoid bacillus A	9.88
		Bacillus paratyphosus B	23.62
Bacillus pyocyaneus	5.63
		Escherichia coli	43.47
Bacillus enteritidis	24.16
		Staphylococcus aureus	5.74

As seen from Table 2, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, bacillus enteritidis.

Illustrate: human intestines and stomach belongs to hollow organ, in the ordinary course of things, B ultrasonic is utilized can not well to show coat of the stomach level, calcium carbonate all containing certain ingredients in Mirabilitum crystallina in contrast agent of the present invention and Bal(n)phyllia sp., with in gastric acid and after can produce carbon dioxide bubble, and Chinese medicine contrast agent of the present invention is when taking or need the 100-400ml that drinks water after taking, obvious promoting the circulation of QI to relieve pain are played after making various Chinese Medicine and Clavicular, the effect of removing food stagnancy stomach function regulating, more clear on image, the strong reecho of point-like, see that coat of the stomach clear layer is visible, and this contrast agent takes down, stomach week mucosa is played a protective role, ultrasound display screen can see gastral cavity size, form, cardia, pylorus, gastric antrum, lesser gastric curvature, place's video pictures such as greater gastric curvature are obvious, each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display is clear, also can clarify a diagnosis to stomach week status of lymph node metastasis.Contrast agent of the present invention help shadow principle as follows: produce carbon dioxide bubble in the calcium carbonate in contrast agent He after gastric acid, drink water 100 ~ 400 milliliters and to swim phenomenon in " flakes " afterwards, because the stickum in contrast agent is cliqued graph resemble ulcer, cancerous protuberance mucomembranous surface being built up, be fused into rope block or light, form obvious interface, because contrast agent can make gastral cavity fill the difference causing gastric wall mucus in acoustic impedance, thus show stomach form, position, gastral cavity size, wall of stomach thickness, emptying time and gastropathy place situation.

The Chinese medicine contrast agent that stomach B ultrasonic of the present invention uses is pure Chinese medicine contrast agent, no side effects, taking convenience, and video picture is clear, strengthens the effect of gastric protective barrier, and diagnosis accurately, is taken through 172 examples are clinical, various disease of stomach of clarifying a diagnosis.Within oral oral solutions 20ml, 8-20 of the present invention minute, stomach bubble can be got rid of, eliminate mucus and make the display of coat of the stomach structure clear, clear display stomach different lesions, imaging results is good, and resolving power is high, image stabilization, can carry out stomach ultrasound diagnosis with various ordinary ultrasonography b instrument.According to clinical diagnostic tests, excellent visualization ratio 95.3% (164/172), general visualization ratio 4.7%

(8/172), acute gastritis, chronic gastritis, gastric ulcer, gastrorrhagia, prolapse of gastric mucosa, gastric cancer, gastroptosis and gastrolith etc. can be gone out by auxiliary diagnosis.(development criterion: excellent: developer is full good, bubble-free and mucus interference in coat of the stomach, the display of gastric mucosa face is clear, and coat of the stomach five-layer structure is clear and legible.General: developer is full good, have a small amount of bubble and mucus interference in coat of the stomach, mucosal surface display is more clear, and coat of the stomach five-layer structure is still clear, but does not affect detection.Bad: to have a large amount of bubble and mucus in gastral cavity, mucosal surface display is unclear, and coat of the stomach level is beyond recognition, and impact detects.)

Concrete case: high certain, man, 44 years old, patient's epigastrium often had a dull ache, do not like diet, distension and fullness in the abdomen, abdominal distention gradually increased the weight of afterwards, belch is frequent, and after belch, pain slightly subtracts, and has heartburn, acid regurgitation once in a while, be admitted to hospital and seek medical advice, take oral solutions 20ml of the present invention, after 12 minutes, ultrasound diagnosis, gastric bubble is eliminated clean, and the display of coat of the stomach structure is clear, find that gastric wall mucus echo is crude, in conjunction with other symptoms, be diagnosed as chronic gastritis.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. a stomach ultrasound diagnosis Chinese medicine contrast agent, it is characterized in that, described Chinese medicine contrast agent comprises following raw medicinal material: Rhizoma valerianae latifoliae, Flos Rosae Rugosae floral leaf, Juncus amplifolius A. Camus, Radix Aristolochiae yunnanensis, Fructus Pratiae Begonifoliae, Herba vallisneriae Spiralis, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani, Herba Adenostemmatis, Herba Pogostemonis, Herba Thlaspis, Folium pyri, Spica piperis betlis, Flos Rosae Rugosae, Radix Achyranthis Bidentatae, Herba Penthori chinensis, Radix Pseudostellariae, Herba Seu Radix Peperomiae Tetraphyllae and Retinervus Luffae Fructus.

2. stomach ultrasound diagnosis Chinese medicine contrast agent as claimed in claim 1, it is characterized in that, the ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent is: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 20 parts, Folium Euryales 12 ~ 22 parts, Mirabilitum crystallina 20 ~ 30 parts, Bal(n)phyllia sp. 14 ~ 24 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 ~ 20 parts, Radix vitis romanetii 20 ~ 30 parts, Radix Raphani 15 ~ 25 parts, Herba Adenostemmatis 20 ~ 30 parts, Herba Pogostemonis 8 ~ 18 parts, Herba Thlaspis 10 ~ 20 parts, Folium pyri 20 ~ 30 parts, Spica piperis betlis 25 ~ 35 parts, Flos Rosae Rugosae 12 ~ 22 parts, Radix Achyranthis Bidentatae 20 ~ 30 parts, Herba Penthori chinensis 15 ~ 25 parts, Radix Pseudostellariae 20 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 10 ~ 20 parts and Retinervus Luffae Fructus 22 ~ 32 parts.

3. stomach ultrasound diagnosis Chinese medicine contrast agent as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent is: Citrus chachiensis Hort. (C．Suavissima Tanaka) 10 ~ 15 parts, Folium Euryales 13 ~ 18 parts, Mirabilitum crystallina 22 ~ 27 parts, Bal(n)phyllia sp. 16 ~ 21 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 15 ~ 20 parts, Radix vitis romanetii 23 ~ 28 parts, Radix Raphani 18 ~ 23 parts, Herba Adenostemmatis 25 ~ 30 parts, Herba Pogostemonis 10 ~ 15 parts, Herba Thlaspis 13 ~ 18 parts, Folium pyri 22 ~ 26 parts, Spica piperis betlis 28 ~ 33 parts, Flos Rosae Rugosae 14 ~ 19 parts, Radix Achyranthis Bidentatae 22 ~ 26 parts, Herba Penthori chinensis 17 ~ 22 parts, Radix Pseudostellariae 25 ~ 30 parts, Herba Seu Radix Peperomiae Tetraphyllae 13 ~ 18 parts and Retinervus Luffae Fructus 24 ~ 29 parts.

4. the stomach ultrasound diagnosis Chinese medicine contrast agent as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent is: Citrus chachiensis Hort. (C．Suavissima Tanaka) 14 parts, Folium Euryales 15 parts, Mirabilitum crystallina 26 parts, Bal(n)phyllia sp. 17 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 18 parts, Radix vitis romanetii 25 parts, Radix Raphani 22 parts, Herba Adenostemmatis 26 parts, Herba Pogostemonis 14 parts of, Herba Thlaspiss 15 parts, Folium pyri 25 Fen, Spica piperis betlis 29 parts, Flos Rosae Rugosae 18 parts, Radix Achyranthis Bidentatae 24 parts, Herba Penthori chinensis 21 parts, Radix Pseudostellariae 26 parts, Herba Seu Radix Peperomiae Tetraphyllae 16 parts and Retinervus Luffae Fructus 25 parts.

5. the stomach ultrasound diagnosis Chinese medicine contrast agent as described in Claims 1-4, it is characterized in that, the ratio of weight and number of the various raw medicinal materials of described Chinese medicine contrast agent is: Citrus chachiensis Hort. (C．Suavissima Tanaka) 12 parts, Folium Euryales 16 parts, Mirabilitum crystallina 24 parts, Bal(n)phyllia sp. 20 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 16 parts, Radix vitis romanetii 28 parts, Radix Raphani 20 parts, Herba Adenostemmatis 30 parts, Herba Pogostemonis 12 parts of, Herba Thlaspiss 16 parts, Folium pyri 22 Fen, Spica piperis betlis 32 parts, Flos Rosae Rugosae 15 parts, Radix Achyranthis Bidentatae 25 parts, Herba Penthori chinensis 18 parts, Radix Pseudostellariae 28 parts, Herba Seu Radix Peperomiae Tetraphyllae 14 parts and Retinervus Luffae Fructus 27 parts.

6. the stomach ultrasound diagnosis Chinese medicine contrast agent as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine contrast agent is oral solutions, and its preparation method comprises the following steps:

The first step, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani and Herba Adenostemmatis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

7. the stomach ultrasound diagnosis Chinese medicine contrast agent as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine contrast agent is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

8. the stomach ultrasound diagnosis Chinese medicine contrast agent as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine contrast agent is oral solutions, and its preparation method comprises the following steps:

The first step, Citrus chachiensis Hort. (C．Suavissima Tanaka), Folium Euryales, Mirabilitum crystallina, Bal(n)phyllia sp., Folium potentillae velutinae (Radix Potentillae Fulgentis), Radix vitis romanetii, Radix Raphani and Herba Adenostemmatis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

9. the stomach ultrasound diagnosis preparation method of Chinese medicine contrast agent as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine contrast agent is powder, and it comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.