CN105879065A - Medicinal preparation for contrast media for gastrointestinal color Doppler ultrasound and preparation methods of medicinal preparation - Google Patents
Medicinal preparation for contrast media for gastrointestinal color Doppler ultrasound and preparation methods of medicinal preparation Download PDFInfo
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- CN105879065A CN105879065A CN201610219162.3A CN201610219162A CN105879065A CN 105879065 A CN105879065 A CN 105879065A CN 201610219162 A CN201610219162 A CN 201610219162A CN 105879065 A CN105879065 A CN 105879065A
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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Abstract
The invention relates to a medicinal preparation for contrast media for gastrointestinal color Doppler ultrasound and preparation methods of the medicinal preparation. The medicinal preparation in the formula is prepared from components in parts by weight as follows: nacre, mussels, szechuan lovage rhizomes, garden burnet roots, south dodder seeds, gordon euryale seeds, leaves of cluster mallow, spina date seeds, liquorice, baical skullcap roots, Chinese bastardtoadflax herbs, euphorbia maculata, lance asiabell roots and herbs of common nasturtium. Two conventional preparation methods are provided, are simple and convenient to operate and can be used for industrial production; a water decoction can be suitable for a single patient to take, and the medicinal preparation has a treatment effect, has the characteristics of high curative efficacy, fast effect, short treatment course and the like, is low in expense, safe and free of safe and toxic reactions and has higher social value; clinical tests indicate that the medicinal preparation has a remarkable effect.
Description
Technical field
The invention belongs to field of medicaments, particularly relate to pharmaceutical preparation of a kind of gastrointestinal color ultrasound contrast agent and preparation method thereof.
Background technology
The development of human diseases promotes the continuous renewal of detection means, and contrast agent one dazzling " star ", contrast agent is (again
Claim contrast medium, contrastmedia) it is to inject (or taking) to tissue or the change of organ for strengthening Imaging Study effect
Learn goods.The density of these goods is higher or lower than surrounding tissue, and the contrast of formation shows image with some apparatus.As x-ray is seen
Examine conventional Operand, barium sulfate etc..
Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three effects greatly to material: one is mechanism,
Owing to ultrasonic energy is huge, often make material particle make altofrequency mechanical vibration, thus produce smash, condense, agitation effects.
Two is warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature raise phenomenon.Three
It is cavitation, when ul-trasonic irradiation is on liquid, in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure
Great variety and become sparse, the most around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.
Owing to human intestines and stomach belongs to hollow organ, generally, color ultrasound is utilized can not well to show coat of the stomach level.Contrast agent
Use can make that gastral cavity is full can well show the form of stomach, gastral cavity size, coat of the stomach level, emptying time and gastropathy
Position, can also show the pathological changes situation of small intestinal and colon simultaneously.The traditional Chinese medical science, as traditional motherland's medical science, has unrivaled excellent
Gesture.
Chinese medicine composition the most extensively gets up as the application of contrast agent at present, such as Chinese invention patent application number: 01128137.5
Provide a kind of for color gastrointestinal ultrasonic contrast medium, be made up of Margarita 1 part, Concha Haliotidis 1 part, Endoconcha Sepiae 1 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part,
Can clarify a diagnosis human body gastritis, gastric ulcer, gastric cancer, gastroptosis, prolapse of gastric mucosa, duodenal bulbar inflammation, duodenal bulb
The disease such as cancerous protuberance at portion's ulcer, phase morning, noon and afternoon gastrointestinal tumor, esophagus upper-lower section and cardia.
Chinese invention patent application number 200810238127.1 discloses Chinese medicine contrast agent of a kind of B ultrasonic use and preparation method thereof, its
Contrast agent includes the various raw materials of following portions by weight ratio: Concha Haliotidis 10～20 parts, Concha Erosariae seu Cypraeae 10～20 parts, Massa Medicata Fermentata 10～20 parts,
Radix Codonopsis 10～20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 parts, Poria 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Herba Patriniae 10～20 parts, the Radix Linderae 10～
20 parts, the Radix Aucklandiae 10～20 parts.
Chinese invention patent application number 201210364551.7 has supplied a kind of Chinese medicine gastrointestinal contrast agent for B ultrasonic and preparation method thereof,
Chinese medicine includes following raw medicinal material: Fructus Foeniculi, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, the Radix Linderae, Endoconcha Sepiae, Pericarpium Citri Reticulatae Viride, Massa Medicata Fermentata, Fructus Hordei Germinatus, trifoliate orange
Reality, Radix Et Rhizoma Rhei, Natrii Sulfas, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Fructus Amomi, Herba Pogostemonis, Fructus Citri Sarcodactylis, Fructus Crataegi, Semen Raphani, Concha Arcae (calcined), Fructus Evodiae, half
Summer, Semen Arecae, the Rhizoma Atractylodis Macrocephalae, Radix Et Rhizoma Nardostachyos and Bulbus Fritillariae Thunbergii.
Chinese patent CN201510487240 gastrointestinal tract contrast medium, it is disclosed that barium sulfate 50～70 parts, Chinese medicine extract
25～35 parts, Mel 50～80 parts and water 300～500 parts；Wherein Chinese medicine extract is formulated by following raw material of Chinese medicine: tiger
Sting 20～30 parts, Radix Berchemiae Giraldianae 20～30 parts, soil Radix Adenophorae (Radix Glehniae) 20～30 parts, white residual flower 10～15 parts, the Rhizoma Pinelliae 10～15 parts, Monas cuspurpureus Went 10～
15 parts, Herba Asplenii Incisi 10～15 parts, Radix Rehmanniae 10～15 parts, the Fructus Sophorae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, the Radix Astragali 5～10 parts, bavin
5～10 parts recklessly, the present invention have gastrointestinal peristalsis inhibition too fast, auxiliary barium meal swallow, nourish gastrointestinal tract and suppression gastrorrhagia advantage.
The most conventional contrast agent is mainly barium sulfate and Operand, and it is to draw that right existing research it turned out existing contrast agent consumption
Play the independent hazard factor of contrast agent nephropathy.In addition contrast agent patient Herba Urticae Cannabinae can also be caused to examine, angioedema, laryngeal edema,
The idiosyncratic reactions such as bronchospasm, serious blood pressure drops and sudden death.The most this kind of contrast agent adds additionally to gastrointestinal tract
Burden, add the misery of patient.
Summary of the invention
For the defect of prior art, the present invention be directed to the present situation treated at present, it is provided that the medicine of a kind of gastrointestinal color ultrasound contrast agent
Thing preparation and preparation method thereof, and have no side effect, effective.
Specifically, the concrete scheme of the present invention is achieved in that
First, inventor provides the pharmaceutical preparation of a kind of gastrointestinal color ultrasound contrast agent according to drug matching experience, in containing in prescription
Medicine composition is: Concha Margaritifera, Mytilus, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Folium Malvae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae,
Herba Thesii, Herba Euphorbiae supinae, Radix Codonopsis lanceolatae, Herba Tropaeoli.
Further, inventor provides a kind of pharmaceutical preparation for gastrointestinal color ultrasound contrast agent, prescription according to drug matching experience
Each raw material dosage in the weight portion scope of the present invention, all there is preferable curative effect, described formula and weight portion and be: Margarita
Female 15-25 part, Mytilus 15-30 part, Rhizoma Chuanxiong 12-16 part, Radix Sanguisorbae 6-12 part, Semen Cuscutae 5-12 part, Semen Euryales 4-11 part,
Folium Malvae 10-20 part, Semen Ziziphi Spinosae 8-15 part, Radix Glycyrrhizae 6-12 part, Radix Scutellariae 5-10 part, Herba Thesii 7-14 part, Herba Euphorbiae supinae 3-8
Part, Radix Codonopsis lanceolatae 6-11 part, Herba Tropaeoli 6-14 part.
Carrying out preferably, reaching superior technique effect to the formula of above-mentioned weight portion, preferred formula is: Concha Margaritifera 18 parts,
Mytilus 22 parts, Rhizoma Chuanxiong 14 parts, Radix Sanguisorbae 9 parts, Semen Cuscutae 8.5 parts, Semen Euryales 7.5 parts, Folium Malvae 15 parts, Semen Ziziphi Spinosae 12.5
Part, 9 parts of Radix Glycyrrhizae, Radix Scutellariae 7.5 parts, Herba Thesii 10.5 parts, Herba Euphorbiae supinae 6 parts, Radix Codonopsis lanceolatae 8 parts, Herba Tropaeoli 10 parts.
Or:
Concha Margaritifera 20 parts, Mytilus 20 parts, Rhizoma Chuanxiong 13 parts, 10 parts, Semen Cuscutae 9.5 parts, Semen Euryales 7.5 parts, Folium Malvae
16 parts, Semen Ziziphi Spinosae 13.5 parts, 10 parts of Radix Glycyrrhizae, Radix Scutellariae 8.5 parts, Herba Thesii 9.5 parts, Herba Euphorbiae supinae 6.5 parts, Radix Codonopsis lanceolatae 8.5
Part, Herba Tropaeoli 11 parts.
In pharmaceutical preparation described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, the Chinese medicine used
Amount rationally, all medicines share after for there is preferable effect for gastrointestinal contrast agent.
The function of each taste Chinese crude drug used in the pharmaceutical preparation of the treatment of the present invention is as follows:
Concha Margaritifera: acrid in the mouth, property is put down.
Function cures mainly: heat-clearing and toxic substances removing, solves administration.For enteritis, lung abscess, tonsillitis, middle administration, acute mastitis, lymph node
Tuberculosis, acute cystitis.
Mytilus: sweet in the mouth, warm in nature.
Function cures mainly: qi-restoratives, removes irritable feverish sensation in the chest, fall borax poison.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.
Gui Jing: return liver, gallbladder, pericardium channel.
Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen suffers from abdominal pain, breast side of body twinge, fall flutter swollen
Bitterly, headache, rheumatic arthralgia.
Radix Sanguisorbae: bitter in the mouth, acid, puckery, is slightly cold.
Function cures mainly: cooling blood for hemostasis, sore of detoxifying.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Semen Cuscutae: sweet in the mouth, warm in nature.
Gui Jing: return liver,kidney,spleen warp.
Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal, for impotence and seminal emission, and dripping urination, enuresis frequent micturition,
Soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down.
Semen Euryales: sweet in the mouth, puckery is flat.
Gui Jing: return spleen, kidney channel.
Function cures mainly: supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine,
Leukorrhagia
Folium Malvae: sweet in the mouth, cold in nature.
Function cures mainly: heat clearing away. row water, laxation.Control cough due to lung-heat, pyretic toxicity dysentery, jaundice, constipation and anuresis, erysipelas, incised wound.
Semen Ziziphi Spinosae: sweet in the mouth is nontoxic.
Function cures mainly: can pacify and the five internal organs, big reinforcing the heart spleen.Therefore blood does not return spleen, and the peaceful person that dosses, multiplex it.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Radix Scutellariae: bitter in the mouth, cold in nature.
Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.
Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery,
Jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Herba Thesii: acrid in the mouth, property is put down.
Function cures mainly: heat-clearing and toxic substances removing, solves administration.For enteritis, lung abscess, tonsillitis, middle administration, acute mastitis, lymph node is tied
Core, acute cystitis.
Herba Euphorbiae supinae: acrid in the mouth, property is put down.
Function cures mainly: hemostasis, clearing away damp-heat, lactogenesis.Harness the Yellow River subcutaneous ulcer, have loose bowels, infantile malnutrition, dysentery, hematuria, metrorrhagia, traumatic hemorrhage, breast
Juice is few, carbuncle sore tumefacting virus.
Radix Codonopsis lanceolatae: sweet in the mouth, property is put down
Gui Jing: return spleen；Lung meridian
Function cures mainly: supplementing QI and nourishing YIN；Removing toxic substances and promoting subsidence of swelling；Evacuation of pus；Lactogenesis.Main spiritlessness and weakness；Dizziness headache；Lung abscess；Acute mastitis；Before intestinal
Journey；Furuncle toxic swelling；Throat moth；Scrofula；Puerperal, breast was few；Leucorrhea；Venom.
Herba Tropaeoli: acrid in the mouth, cool in nature.
Gui Jing: the heart, kidney channel.
Effect and effect: heat-clearing and toxic substances removing；Cooling blood for hemostasis.Main conjunctival congestion and swelling pain；Furuncle；Spit blood；Spitting of blood.
Color ultrasound gastrointestinal contrast agent of the present invention is oral administration, and its pharmaceutical dosage form can be powder, granule.
The present invention is to above prescription through conscientious research, and according to the reasonability of middle medical drugs, invention proposes stomach of the present invention
The preparation method of intestinal contrast agent, concretely comprises the following steps:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mix powder and mix homogeneously, obtain powder.
The preparation method of granule of the present invention is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mixed powder mixs homogeneously, pelletizes, be vacuum dried, granulate, obtain the present invention
Granule.
Granule of the present invention often wraps weight 10g；The vacuum drying temperature of the present invention controls at 40-50 DEG C.
The granule of the present invention is as the usage and dosage of color ultrasound gastrointestinal contrast agent:
By granule 10-20g of the present invention, it is dissolved in 70-80 DEG C of boiled water of 100-300ml, decoction being taken warmly.
Or granule 10-20g of the present invention, adds appropriate 70-80 DEG C of boiled water, and furnishing is dense and burned, swallows, and then drinks 100-300
Temperature boiled water.
Pharmaceutical preparation of the present invention can serve as contrast agent and uses.
The pharmaceutical preparation of the present invention purposes in preparation treatment gastrointestinal disease medicine is also used as the medicine into treating gastric ulcer
Thing uses.
Gastrointestinal disease of the present invention is gastric ulcer, acute gastritis, chronic gastritis or duodenal ulcer.
Pharmaceutical preparation of the present invention is used for, and compared with prior art has the advantage that
(1) present invention provides two kinds of conventional preparation methoies, easy and simple to handle, can carry out industrialized production, and water decoction can be fitted
The features such as conjunction individual patients is taken, and it is high that the therapeutic effect of the medicine of the present invention has curative effect, instant effect, short treating period, and expense
Low, safety non-toxic side reaction, there is higher social value, find through clinical trial, pharmaceutical preparation of the present invention has substantially
Effect.
(2) pharmaceutical preparation of the present invention both can use as contrast agent, again can be as the drug use for the treatment of gastric ulcer.
Using as contrast agent, easy to use, good in taste, the image of formation is clear, coat of the stomach clear layer is visible, and each position is sick
Stove is high-visible.
Specific embodiment
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing substantially from
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from which
From the point of view of Dian, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by claims
Rather than described above limits, it is intended that all changes fallen in the implication of equivalency and scope of claim are included
In the present invention.
Embodiment 1: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 15 grams, Mytilus 15 grams, Rhizoma Chuanxiong 12 grams, Radix Sanguisorbae 6 grams, Semen Cuscutae 5 grams, Semen Euryales 4 grams, Folium Malvae 10
Gram, Semen Ziziphi Spinosae 8 grams, 6 grams of Radix Glycyrrhizae, Radix Scutellariae 5 grams, Herba Thesii 7 grams, Herba Euphorbiae supinae 3 grams, Radix Codonopsis lanceolatae 6 grams, Herba Tropaeoli 6
Gram.
Preparation method is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mixed powder mixs homogeneously, pelletizes, be vacuum dried, granulate, obtain the present invention
Granule.
Embodiment 2: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 25 grams, Mytilus 30 grams, Rhizoma Chuanxiong 16 grams, Radix Sanguisorbae 12 grams, Semen Cuscutae 12 grams, Semen Euryales 11 grams, Semen Abutili
20 grams of leaf, Semen Ziziphi Spinosae 15 grams, 12 grams of Radix Glycyrrhizae, Radix Scutellariae 10 grams, Herba Thesii 14 grams, Herba Euphorbiae supinae 8 grams, Radix Codonopsis lanceolatae 11
Gram, Herba Tropaeoli 14 grams.
Preparation method is with embodiment 1.
Embodiment 3: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 18 grams, Mytilus 22 grams, Rhizoma Chuanxiong 14 grams, Radix Sanguisorbae 9 grams, Semen Cuscutae 8.5 grams, Semen Euryales 7.5 grams, Semen Abutili
15 grams of leaf, Semen Ziziphi Spinosae 12.5 grams, 9 grams of Radix Glycyrrhizae, Radix Scutellariae 7.5 grams, Herba Thesii 10.5 grams, Herba Euphorbiae supinae 6 grams, Radix Codonopsis lanceolatae 8
Gram, Herba Tropaeoli 10 grams.
Preparation method is with embodiment 1.
Embodiment 4: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 20 grams, Mytilus 20 grams, Rhizoma Chuanxiong 13 grams, 10 grams, Semen Cuscutae 9.5 grams, Semen Euryales 7.5 grams, Folium Malvae
16 grams, Semen Ziziphi Spinosae 13.5 grams, 10 grams of Radix Glycyrrhizae, Radix Scutellariae 8.5 grams, Herba Thesii 9.5 grams, Herba Euphorbiae supinae 6.5 grams, Radix Codonopsis lanceolatae 8.5
Gram, Herba Tropaeoli 11 grams.
Preparation method is with embodiment 1.
Embodiment 5: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 15 grams, Mytilus 15 grams, Rhizoma Chuanxiong 12 grams, Radix Sanguisorbae 6 grams, Semen Cuscutae 5 grams, Semen Euryales 4 grams, Folium Malvae 10
Gram, Semen Ziziphi Spinosae 8 grams, 6 grams of Radix Glycyrrhizae, Radix Scutellariae 5 grams, Herba Thesii 7 grams, Herba Euphorbiae supinae 3 grams, Radix Codonopsis lanceolatae 6 grams, Herba Tropaeoli 6
Gram.
Preparation method is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mix powder and mix homogeneously, obtain powder.
Embodiment 6: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 25 grams, Mytilus 30 grams, Rhizoma Chuanxiong 16 grams, Radix Sanguisorbae 12 grams, Semen Cuscutae 12 grams, Semen Euryales 11 grams, Semen Abutili
20 grams of leaf, Semen Ziziphi Spinosae 15 grams, 12 grams of Radix Glycyrrhizae, Radix Scutellariae 10 grams, Herba Thesii 14 grams, Herba Euphorbiae supinae 8 grams, Radix Codonopsis lanceolatae 11
Gram, Herba Tropaeoli 14 grams.
Preparation method is with embodiment 5.
Embodiment 7: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 18 grams, Mytilus 22 grams, Rhizoma Chuanxiong 14 grams, Radix Sanguisorbae 9 grams, Semen Cuscutae 8.5 grams, Semen Euryales 7.5 grams, Semen Abutili
15 grams of leaf, Semen Ziziphi Spinosae 12.5 grams, 9 grams of Radix Glycyrrhizae, Radix Scutellariae 7.5 grams, Herba Thesii 10.5 grams, Herba Euphorbiae supinae 6 grams, Radix Codonopsis lanceolatae 8
Gram, Herba Tropaeoli 10 grams.
Preparation method is with embodiment 5
Embodiment 8: a kind of granule for color ultrasound contrast agent and application thereof, containing following raw material medicine:
Concha Margaritifera 20 grams, Mytilus 20 grams, Rhizoma Chuanxiong 13 grams, 10 grams, Semen Cuscutae 9.5 grams, Semen Euryales 7.5 grams, Folium Malvae
16 grams, Semen Ziziphi Spinosae 13.5 grams, 10 grams of Radix Glycyrrhizae, Radix Scutellariae 8.5 grams, Herba Thesii 9.5 grams, Herba Euphorbiae supinae 6.5 grams, Radix Codonopsis lanceolatae 8.5
Gram, Herba Tropaeoli 11 grams.
Preparation method is with embodiment 5.
Embodiment 9: animal model test
9.1, animal model modeling and packet
Kunming rat 70, between body weight 180-220g, rat pre-operative anxiety 12h, normal group 5, sham operated rats 5, model
Organize 15, omeprazole group 15, embodiment 3 granule low dose group (A group) 15, embodiment 3 granule high dose (B
Group) organize 15, freely drink oresol (OregonRevisedStatutes, ORS), ORS formula is sodium chloride 3.5
Gram, sodium bicarbonate 2.5 grams, 1.5 grams of potassium chloride, glucose powder 20 grams add pure water to 1000ml.
Rat pre-operative anxiety, freely drink oresol 12-16h, 10% chloral hydrate (3.5mL/kg weight) intramuscular injection fiber crops
Liquor-saturated.With 0.5% iodophor disinfection rat abdomen skin, open abdomen along left rib lower edge, stomach is pulled out gently.
Clamp away from pyloric part 3mm body of stomach region with tweezers.0.18mL mineral oil and the syringe of 0.02mL60% acetic acid will be inhaled in advance
Syringe needle insert and hold under the arm in the gastral cavity of closed zone, in the gastral cavity holding closed zone under the arm, inject 0.18mL mineral oil and 0.02mL60% acetic acid, 45s
After from stomach sucking-off acetic acid, then in gastral cavity inject 2mL normal saline, sucking-off after 1min, with terminates react.Stomach is resetted,
Penicillin sodium injection 0.1mL (adding 800,000 units of Penicillin sodium, mixing with 4mL normal saline) is instilled, successively in otch
Close abdomen.Sham-operated control group replaces acetic acid with sterilizing pure water.Postoperative Rat Fast, freely drink oresol.Art operates
Gently rub and note sterile working, to reduce adhesion.
9.2, administering mode and operation
Postoperative Rat Fast 24h, freely drinks oresol.Normally taking food after 12h water, drinking water is pure water, and every day throws in
Mus grain want quantitative management.Omeprazole (AstraZeneca) is by 6.25 times of calculating rat effective doses, i.e. 1.04mg/kg of people's dosage
Body weight gavage, once a day；The embodiment of the present invention 3 granule high and low dose group difference gastric infusion 4g/kg, 2g/kg, every day
Once, administration time is 9:00.Rat Fast, freely drink water 10% chloral hydrate intraperitoneal anesthesia (3mL/kg weight) after 24h.
Opening abdomen, ventral aorta is taken a blood sample, not anticoagulant, and after stand at low temperature 2h, 3 000r/min are centrifuged 10min, collects the standby ELISA method of serum
Detection.Taking out stomach, cut off along greater gastric curvature, gastric mucosa is rinsed well by normal saline, takes out at stomach ulcer, and-70 DEG C of refrigerators are protected
Deposit, in case ELISA method detection.
9.3, serum PG E2 content detection
Adding sample diluting liquid as blank, be sequentially added in hole by standard substance, remaining each hole adds Sample serum 50 μ L, at mark
Quasi-sample wells and sample well add the enzyme labelling liquid of 100 μ L, 36 DEG C of incubation reaction 60min.Washing liquid is cleaned after 5 times at the bottom of every hole addition
The each 50 μ L of thing A, B liquid, 36 DEG C of Incubation in dark reaction 15min.Every hole adds 50 μ L stop buffers, terminates reaction.TECAN is many
Function microplate reader (Infinite M200, Austria) measures 450nm OD value.According to standard curve regression equation calculation sample
Concentration.
9.4, gastric tissue homogenate PGE2 content detection
Rat stomach tissue shreds after weighing, and adds normal saline homogenate by 10mL/g, obtains gastric tissue homogenate.Add sample diluting liquid
As blank, being sequentially added in hole by each for standard substance 50 μ L, remaining each hole adds sample 50 μ L.Sample well adds 10 μ
L biotin labeling liquid, adds the enzyme labelling liquid of 100 μ L in standard sample wells and sample well.36 DEG C of incubation reaction 60min.Washing liquid
After cleaning 5 times, every hole adds substrate A, each 50 μ L of B liquid.36 DEG C of Incubation in dark reaction 15min.Every hole adds 50 μ L stop buffers,
Terminate reaction.Measure 450nm OD value.Concentration according to standard curve regression equation calculation sample.
9.5, gastric tissue homogenate EGF content detection
Rat stomach tissue shreds after weighing, and adds normal saline homogenate by 10mL/g, obtains gastric tissue homogenate.1 hole only adds sample
Each for standard substance 50 μ L, as blank, are sequentially added in hole by diluent, and remaining each hole adds sample 50 μ L.Experimentation is same
" 5.2 " item.
9.6, statistical method
Use SPSS 13.0 software, compare with one factor analysis of variance between group, result all withRepresent, with P < 0.05 as difference
Statistically significant.
9.7, result
Table 1PGE2, PGE2, EGF content such as following table
Note:
Compare with Normal group,##P ＜ 0.01；
Compare with model control group,@P ＜ 0.05,@@P ＜ 0.01；
Compare with omeprazole group,$P ＜ 0.05,$$P ＜ 0.01.
As it can be seen from table 1 by PGE2, PGE2, EGF content, model group is significantly lower than Normal group (P < 0.01),
Show modeling success, and between sham operated rats and Normal group, there is no significant difference, get rid of operation impact；By comparing
PGE2, PGE2, EGF content, omeprazole group and granule of the present invention are low, PGE2, PGE2, EGF of high dose group
Content be significantly lower than model control group (P < 0.01 or P < 0.05), and granule high dose group PGE2 of the present invention, PGE2,
EGF content is significantly lower than omeprazole group (P < 0.05), and both has significant difference, is suitable for further genralrlization application.
Embodiment 10: animal model test and experiment in vitro
Granule prepared by embodiment 1,2,4 and the granule alternate embodiment 9 implementing 5,6,7,8 preparations use
The granule of embodiment 3, repeat embodiment 9, found that the granule of embodiment 1,2,4,5,6,7,8 preparation
There is preferable curative effect.
Embodiment 11, gastrointestinal contrast agent of the present invention clinical setting in treatment gastric ulcer:
11.1, case selection:
Selecting patients w ith peptic ulcer disease 300 example to carry out clinical observation, patient is randomly divided into two groups, treatment group 300 example, respectively treatment group
1. group and 2. group, often organize 100 people, matched group 100 example, respectively organize the factors such as patient medical record, age, sex, health basically identical,
Without significant difference, there is comparability.
11.2, Therapeutic Method:
Treatment group 1. group: the Chinese medicine granules of the oral embodiment of the present invention 3 preparation, each 20g, three times a day, 7 days is a course for the treatment of,
Take 3 courses for the treatment of continuously；The Chinese medicine granules of the ultrasonic examination oral embodiment of the present invention 3 preparation in previous hour.
Treatment group 2. group: the powder of the oral embodiment of the present invention 7 preparation, each 20g, three times a day, 7 days is a course for the treatment of, continuously
Take 3 courses for the treatment of；The powder of the ultrasonic examination oral embodiment of the present invention 7 preparation in previous hour.
Matched group patient: take omeprazole+JUYUANSUNMOSHABILI granule+amoxicillin and clavulanate potassium by therapeutic dose, 10
It is a course for the treatment of, takes continuously 2 courses for the treatment of, previous hour oral barium sulfate of ultrasonic examination.
11.3, Outcome measure:
Radiography is clear: radiography is clear, and gastrointestinal is observed clear, and diseased region is observed clear, and image is clear, the strong reecho of point-like,
Coat of the stomach clear layer is visible, and gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature etc. are aobvious
As substantially, each position focus is high-visible.
Radiography is the most clear: radiography is substantially clear, and gastrointestinal is observed the clearest, and diseased region is observed the clearest, and image is basic
Clearly, the stronger reecho of point-like, coat of the stomach clear layer is visible, gastral cavity size, form, cardia, pylorus, gastric antrum, 12
The imaging such as duodenum 12, lesser gastric curvature, greater gastric curvature is more apparent, and each position focus is high-visible.
It is clear that radiography is smudgy: radiography obscures, and gastrointestinal is observed unclear, and diseased region is observed unclear, and echogenic dots reflects relatively
Weak, coat of the stomach level is chaotic, and gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature etc. are aobvious
As inconspicuous, each position focus is difficult to recognize.
11.4, visualisation
Treatment group: clear 198 examples of radiography, the most clear 2 examples of radiography, clear 0 example that radiography is smudgy；Matched group radiography clear 77
Example, the most clear 15 examples of radiography, clear 8 examples that radiography is smudgy, 5 example patients react barium sulfate and are difficult to swallow, and have vomiting reaction,
3 examples flow to caecum portion in taking barium sulfate 1 hour, it is difficult to observe clear.
11.5, therapeutic outcome:
Cure: ulcer and inflammation all disappear, stomach dull pain, dull pain, distending pain, burn the disappearance of the stomach pain such as sample pain, gastric motility
Recovering, metabolism recovers normal.
Taking a turn for the better: ulcer disappears or ulcer area reduces more than 50%, tissue inflammatory reaction alleviates or disappears about, stomach discomfort
Alleviating, gastric motility has recovered.
Invalid: ulcer area is unchanged or reduces less than 50% or symptom is unchanged.
1. group is wherein treated: curing 88 examples, take a turn for the better 11 examples, invalid 1 example, and cure rate is 88%, and total effective rate is 99% through treatment；
Treating 2. group: cure 85 examples, take a turn for the better 14 examples, invalid 1 example, and cure rate is 85%, and total effective rate is 99%；Matched group: cure
50 examples, take a turn for the better 37 examples, invalid 13 examples, and cure rate is 50%, and total effective rate is 87%.Result above shows, controlling for the treatment of group
More rate and total effective rate are apparently higher than matched group.
Table 2 treatment group and matched group to follow up a case by regular visits to individual treatment effect as follows
| Group | Follow up a case by regular visits to individuality | Relapse individual | Relapse rate |
| Treat 1. group | 88 | 0 | 0 |
| Treat 2. group | 84 | 1 | 1.19% |
| Matched group | 43 | 11 | 25.58% |
Be can be seen that by table 2 ulcer healing patient is carried out when 12 months after terminating the course for the treatment of scope follows up a case by regular visits to, add up ulcer recurrence
Rate.Wherein treat 1. organize 88 examples obtain follow up a case by regular visits to, treatment 2. organize 85 examples obtain follow up a case by regular visits to, matched group healing person 43 people obtain follow up a case by regular visits to, two
Group gastric ulcer recurrence rate compares and is shown in Table 2.More than test result indicate that, Chinese medicine composition of the present invention when for the treatment of gastric ulcer,
Having cure rate high, the advantage being difficult to recurrence, every statistical data is all due to western medicine matched group.
11.6, typical case
Case 1: Zou, female 40 years old, people from Nanchang, over 2014, my institute checks, the long-term anorexia of patient, body weight only has 45
Kilogram, main suit's stomach indigestion of nearest a period of time, often have a stomachache, the contrast agent of embodiment 3 during inspection, is administered orally, go out without vomiting situation
Existing, radiography is clear, and stomach is fishhook-type, on an empty stomach without stomach pool stream；Antrum pleat irregular arrangement, increases thick.Coat of the stomach wriggling
Poor, pyloric cap form is normal, and tentative diagnosis is chronic property gastritis, and in checking process, patient gives an oral account stomachache to be had and alleviate,
And without sense of discomfort, check the complete desire wanted again afterwards and eat.
Claims (9)
1. the pharmaceutical preparation of a gastrointestinal color ultrasound contrast agent, it is characterised in that: described pharmaceutical preparation includes following Chinese crude drug: Concha Margaritifera,
Mytilus, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Folium Malvae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Herba Thesii, Herba Euphorbiae supinae, mountain
Carnis Rapanae thomasianae, Herba Tropaeoli.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
Concha Margaritifera 15-25 part, Mytilus 15-30 part, Rhizoma Chuanxiong 12-16 part, Radix Sanguisorbae 6-12 part, Semen Cuscutae 5-12 part, Semen Euryales 4-11 part,
Folium Malvae 10-20 part, Semen Ziziphi Spinosae 8-15 part, Radix Glycyrrhizae 6-12 part, Radix Scutellariae 5-10 part, Herba Thesii 7-14 part, Herba Euphorbiae supinae 3-8
Part, Radix Codonopsis lanceolatae 6-11 part, Herba Tropaeoli 6-14 part.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
Concha Margaritifera 18 parts, Mytilus 22 parts, Rhizoma Chuanxiong 14 parts, Radix Sanguisorbae 9 parts, Semen Cuscutae 8.5 parts, Semen Euryales 7.5 parts, Folium Malvae 15
Part, Semen Ziziphi Spinosae 12.5 parts, 9 parts of Radix Glycyrrhizae, Radix Scutellariae 7.5 parts, Herba Thesii 10.5 parts, Herba Euphorbiae supinae 6 parts, Radix Codonopsis lanceolatae 8 parts,
Herba Tropaeoli 10 parts.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
Concha Margaritifera 20 parts, Mytilus 20 parts, Rhizoma Chuanxiong 13 parts, 10 parts, Semen Cuscutae 9.5 parts, Semen Euryales 7.5 parts, Folium Malvae 16
Part, Semen Ziziphi Spinosae 13.5 parts, 10 parts of Radix Glycyrrhizae, Radix Scutellariae 8.5 parts, Herba Thesii 9.5 parts, Herba Euphorbiae supinae 6.5 parts, Radix Codonopsis lanceolatae 8.5
Part, Herba Tropaeoli 11 parts.
5. the pharmaceutical preparation prepared described in claim 1-4, it is characterised in that concrete step is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mix powder and mix homogeneously, obtain powder.
6. the pharmaceutical preparation prepared described in claim 1-4, it is characterised in that concrete step is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) Mytilus, Folium Malvae, Herba Thesii, Herba Euphorbiae supinae and Herba Tropaeoli are put into 1500ml pure in, after slow fire is fried open, then decoct slowly
30 minutes, pour out decocting liquid 500ml, add the pure water of 300ml, slow pan-fried 20 minutes, then pour out decocting liquid 200ml, then
Adding the water of 500ml, continue slow decocting 30 minutes, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly；
3) step 2) raw material concentrating under reduced pressure obtains condensed cream；
4) weigh appropriate Concha Margaritifera respectively, Rhizoma Chuanxiong, Radix Sanguisorbae, Semen Cuscutae, Semen Euryales, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Scutellariae, Radix Codonopsis lanceolatae are dried,
Pulverize 80～120 sieves, obtain mixed powder, standby
5) condensed cream is dried, is ground into powder and step 4) mixed powder mixs homogeneously, pelletizes, be vacuum dried, granulate, obtain granule.
Pharmaceutical preparation the most according to claim 6, it is characterised in that step 5) described in granule often wrap weight 10g, described
Vacuum drying temperature controls at 40-50 DEG C.
Pharmaceutical preparation the most according to claim 1, it is characterised in that: described pharmaceutical preparation is in preparing gastrointestinal color ultrasound contrast agent
Application.
Pharmaceutical preparation the most according to claim 1, it is characterised in that: described pharmaceutical preparation is at preparation treatment gastrointestinal disease medicine
In application.
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| CN102068707B (en) * | 2011-01-10 | 2012-05-23 | 张洪英 | Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof |
| CN103495187B (en) * | 2013-10-04 | 2014-11-26 | 王发芬 | Type-B ultrasonic traditional Chinese medicinal gastroenterography assistant and method for preparing same |
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