CN100484548C - Medicine for treating gastritis and its preparation method - Google Patents

Abstract

The name of the invention is: a medicine for curing gastritis and its manufacturing method, which belongs to Chinese traditional medicine field. It is mainly made up of costus root, litchi seed, and placenta all of which are blended together according to a fixed weight proportion. It can be produced into any oral preparation. The medicine has functions of blood nourishing, weak nourishing, warming and invgouating taste, regulating qi and stomach qi and so on. It has a high curative rate for each kind of chronic gastritis, the medicine acts quickly.

Description

A kind of medicine for the treatment of gastritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of gastritis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Gastritis is disease the most common in the internal medicine digestive disease, chronic gastritis accounts for 50% of general gastroenteropathy, because primary disease lacks characteristic symptom clinically, thus difficulty is often felt in the diagnosis of gastritis, especially to the more difficult clinically accurate diagnosis of chronic gastritis.Do not relax with epigastrium clinically, glutted after loss of appetite, nausea and vomiting, the food, asthenia universalis, becoming thin is feature.Western medical treatment: dispel the cause of disease, protect from infection, promote inflammation healing, prevent that inflammation from sending out adequate nutrition, the application of promoting digestion and invigorating the stomach medicine again.The tcm methods of this disease of treatment comprises at present: acupuncture-moxibustion, the qigong, massage and Chinese medicine for oral administration are several.Acupuncture-moxibustion can ease the pain, relief of symptoms, improve gastrointestinal function, the acupuncture-moxibustion acupuncture point; Middle wrist, bl, tsu san li, Nei Guan, side of body costalgia adds the Zhangmen bl as holding concurrently.The appetite indigestion adds bl, Jianli (CV 11), Liangqiu, Neiting, middle void, catching cold adds Pishu, Zhangmen, three cloudy Jiao.QI GONG therapy is got the breathing exercises method.Adopt the abdomen formula to deeply breathe and the omphaloskepsis, make the interior internal organs of abdomen like the massage that is subjected to the rhythm and pace of moving things, promote gastrointestinal peristalsis, eupepsy is strengthened, improve digestive and absorptive functions, massage therapy: with regulating QI to relieve pain is general therapy, and basic acupuncture point is middle wrist, Qihai, Tianshu tsu san li, maneuver for rub, by, rub, push away.Though these methods have certain auxiliary curative effect to gastritis, there is the patient to adhere to the defective that is difficult for.Chinese medicine for oral administration comprises: add the flavor Sini San, add the flavor Rhizoma Pinelliae, Cortex Magnoliae Officinalis soup, Liver-Comforting Decoction, XIAOYAO POWDER, add flavor Rhizoma Coptidis Colla Corii Asini soup, Fructus Evodiae soup Xiangsha Liujunzi decoction, Radix Astragali is built middle soup, MOLUO DAN, though these medicines have certain curative effect but still can not be satisfactory.

Summary of the invention

Therefore, people still deposit needs to the Chinese medicine preparation that curative effect is better treated gastritis, up to now, also do not find the report of any relevant invention pharmaceutical composition, the inventor is through repeatedly research, and the card of the examination by animal and clinical trial, find the oral medicinal herb medicine that the treatment of better curative effect gastritis is arranged finally, thereby finished the present invention.

The object of the invention just provides a kind of a kind of Chinese medicine composition of more effective treatment gastritis, especially chronic gastritis.

Another object of the present invention has provided the preparation of compositions method of this Chinese medicine.

Medicament selection Radix Aucklandiae (Radix Vladimiriae) of the present invention, Semen Litchi, Placenta Hominis, Chinese liquor are formed, and make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat gastritis.Wherein select for use Radix Aucklandiae (Radix Vladimiriae) to be because warm in nature, the bitter in the mouth suffering is nontoxic, goes into spleen meridian and the positive stomach warp of foot, sector-style intestinal stasis relieving, the appetizing warming the stomach, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO is the diffusing medicine of three warmers edema caused by disorder of QI, is to want with middle Jiao especially so, can rise and to fall, can loose and mend, Deficiency and coldness of spleen and stomach is stagnated in the ore deposit and all gastrointestinal distresss have unique effect, diffusing stagnant gas, transfers all gas, easing stomach-QI, lets out lung qi, strengthening the spleen to promote digestion.Select for use Semen Litchi to be because Semen Litchi sweet in the mouth wall warm in nature is nontoxic, go into Liver and kidney two warps, gas, the heresy of going to a winter resort of stagnating of loosing treated for stomachache and hernia.Select for use Placenta Hominis to be because salty in the mouth warm in nature, nontoxicly fill blood, control strain, the strong vital organs of the human body.Placenta Hominis is given birth to by my QI and blood, so the energy strongly invigorating QI and blood is controlled all asthenia and decreased utmost points (deficient person's one damage lung, lustreless skin hair dropped.The two damage hearts, blood vessels decline few, and three damage spleens, emaciation take off.Four decrease the liver muscular atonia does not receive.Five serious conditions of leprosy involving five ZANG-organs kidney, hectic fever due to YIN-deficiency do not rise.Six types of severe debility disease person says QI exhaustion, bood exhaustion, tendon exhaustion, bone exhaustion, the flesh utmost point, essence exhaustion) Placenta Hominis possess essence and blood knot pregnant after liquid, female QI and blood is in the majority, so the high benefit nutrient blood of energy.Selecting for use Chinese liquor for drawing, is because wine can manage it the medicine gesture, regulating QI and blood, the bitter but sweet flavor suffering, extremely hot in nature can kill hundred heresies, vicious gas, promoting blood circulation, thick the intestines and stomach, moisten the foster temper of skin, hold up liver, except that the wind therapeutic method to keep the adverse QI flowing downwards, too lung, go into stomach, temperature is able to nourishing the stomach among must trembling with fear.Reach the invigorating the spleen and benefiting QI blood circulation promoting and blood stasis dispelling so jointly, the purpose of regulate the flow of vital energy relieving distension and stomach and alleviating pain.

The consumption of medicine components of the present invention is also groped to sum up to draw through invention in a large number, and the each component consumption is for all having curative effect preferably in the following weight parts scope:

Radix Aucklandiae (Radix Vladimiriae) 100 gram Semen Litchis 100 gram Placenta Hominiss 200 grams

Medicine each component consumption of the present invention can also be Radix Aucklandiae (Radix Vladimiriae) 125 grams, Semen Litchi 125 grams, Placenta Hominis 250 grams.

The Radix Aucklandiae under among the present invention belongs to the dried root of feverfew Radix Aucklandiae putchuk.

Semen Litchi described in the present invention belongs to the nuclear of doing of the no trouble plant Fructus Litchi Nehelium Litchi Camb of section.

The preparation method of pharmaceutically active component of the present invention is as follows:

Crusher for crushing is put in Radix Aucklandiae (Radix Vladimiriae), Semen Litchi, the Placenta Hominis mixing of described weight proportion again, sieve, three times repeatedly, merge three medicated powder gained electuaries that sieve, wherein Placenta Hominis should hang earlier and tie up on the water tap, after big flood washes a night, put into the steaming of crib slow fire again, airing does not remove peplos.

The active constituent of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, method of Chinese medicinal as routines such as disintegrating agent, lubricant, binding agents is prepared into any peroral dosage form commonly used, as ball, loose, tablet, capsule, oral liquid etc.

Medicine of the present invention has invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, the function of relieving distension and stomach and alleviating pain of regulating the flow of vital energy, and is used for the treatment of various gastritis.

The specific embodiment

Below further set forth the beneficial effect of medicine of the present invention by testing example, these are tested pharmacodynamics test and the clinical observation on the therapeutic effect that examples have comprised medicine of the present invention (hereinafter referred to as the stomach oral granule of healing) and test.

Test example 1: medicine of the present invention is to the influence of rat gastric mucosa.

Test material:

The medicine stomach of the present invention oral granule of healing; Ammonia is produced by silver chemical reagent factory.

Test method:

Get 42 of healthy SD rats, body weight 150-200 restrains this good hero, and each is rich, is divided into matched group, stomach heal totally four groups of electuary group, SANJIU WEITAI group, model group at random, and wherein model group is 12, freely drinks 8 weeks of 0.1% ammonia, causes experimental chronic gastritis.Experiment divides two parts to observe i.e. prevention group and treatment group.Prevention is organized when bringing out gastritis with 2% stomach heal 2 milliliters of electuary, SANJIU WEITAI aqueous solutions, the next day irritate stomach.Treatment is organized in drinking ammonia after 8 weeks, and heal electuary, 2 milliliters of filling 4 weeks of stomach of SANJIU WEITAI aqueous solution with 30% stomach every day respectively.Respectively Mus is put to death after experiment finishes, cut off stomach (big curved example) and use 10% formalin fixed, take from cardia after three days to pyloric lesser carvature side 0.2 * 10mm ²The gastric tissue of size is done not cured section routinely, and H.E dyeing partly selects 2 places to use micrometer at 100 times of downside amounts of light microscopic mucosal thickness at body of stomach and gastric antrum.Press the method difference computation of mean values of Sunao Kowanoet al.

Result of the test:

Model and normal group compare, and the obvious attenuation of gastric mucosa thickness shows that gastric antrum, body of stomach all have atrophy in various degree.Body is compared P＜0.05 with matched group, hole portion side is P＜0.01, illustrates that the atrophy of mucosa is attached most importance to hole portion.And stomach is healed electuary prevention part and model group relatively, and mucosal thickness obviously increases, P＜0.01, stomach heal electuary treatment part and model group relatively, its mucosal thickness also increases to some extent, P＜0.05 SANJIU WEITAI group also has analogue (seeing Table 1).

Table 1 stomach heal electuary to the influence (μ m) of white mouse gastric mucosa * ± SD

Test example 2: the various gastritis clinical observation of Drug therapy of the present invention

1, clinical data:

Accept patient's 258 examples for medical treatment, all through barivm meal fluoroscopy (screem) and gastroscopy, part was made pathological biopsy as the disconnected foundation of diagnosis and treatment, wherein male 165 examples, woman's 93 examples, age 20-30 year 38 people, 30-40 year 56 people, 40-50 year 90 people, 50-60 year 74 people, acute simple gastritis 8 examples, chronic superficial gastritis 134 examples, chronic atrophic gastritis 102 examples, chronic hypertrophic gastritis 16 examples.

The 2 diagnosis and treatment standard of breaking

(1) tcm diagnosis standard

Gastritis belongs to the traditional Chinese medical science " stomach-ache " and " vomiting " category, is cardinal symptom with stomach wrist pain, and the sick position of primary disease is mainly spleen, stomach, liver.The clinical manifestation more complicated, the chronic gastritis differentiation of symptoms and signs for classification of syndrome can be divided into four types:

Liver-stomach disharmony type: main card sees that stomach wrist distending pain, pain lead two sides of body, inappetence, singultus vomiting, thick fur stringy pulse.

Qi stagnation and blood stasis type: main card is seen stomach wrist distending pain, localized pain, the tired work of disgruntled postemphasis heating installation, white, purple dim, the stringy pulse or puckery of body of the tongue of tongue.

Spleen-stomach deficiency-cold: the happiness of stomach wrist dull pain, pain relieved by pressing is warm, singultus pantothenic acid, extremity are not warm, loose stool, light red tongue moist and slippery fur, pulse condition heavy a little less than.

Type of deficiency of stomach yin: main card sees, stomach wrist causalgia, xerostomia desire drink, noisy anorexia, burning sensation on palms and soles, red tongue tongue are few, pulse condition is counted accurately.

(2) Western medicine diagnose standard

Clinical acute gastritis and the chronic gastritis of generally gastritis being divided into.Acute stomach can be divided into simple gastritis, corrosive gastritis, infectiousness gastritis and purulent gastritis again.Chronic gastritis can be divided into chronic superficial gastritis, chronic atrophic gastritis and chronic hypertrophic gastritis.The quite irregular classical symptom that there is no of the clinical manifestation of chronic gastritis, especially the chronic superficial gastritis diagnosis is more because of difficulty.Atrophic gastritis is then with the epigastrium dull pain, and is glutted after the meal, loss of appetite, asthenia universalis etc.That the sign aspect can have is pale, become thin, glossitis, gastric analysis are found achlorhydria in the part patient.Hypertrophic gastritis is a cardinal symptom with the intractable abdominal part bitterly, and gastric analysis hydrochloric acid is too high, the visible gastric folds hypertrophy of X line barivm meal fluoroscopy (screem), and shape is tetanic slightly, and is nodositas.Gastroscopy is the main method of diagnosing chronic gastritis, and its typical case's performance is as follows:

＜1〉chronic superficial gastritis: pathological changes serves as obviously with the bottom of body of stomach often, mostly is diffusivity and can also be limited as a place, and it has mainly been found: (1) canescence, yellow-white or pus sample mucus hide mucosa.(2) limitation mucous hyperemia.(3) edema or with the petechia with rotten to the corn.

＜2〉chronic atrophic gastritis: the normal tangerine color and luster forfeiture of (1) gastric mucosa, shallow with Lycoperdon polymorphum Vitt or celadon, (2) mucous layer attenuation, the visible mucosa shape protuberance slightly around it in the atrophy district of limitation, vascular arborization is high-visible because of the attenuation of gastric mucosa layer under (3) mucosa.

＜3〉chronic menetrier's disease: (1) mucosal fold is thick, irregular velvet sample or the sponge shape of being, and visible transverse fissure has the brief summary of most projectioies on (2) pleat, and (3) are often with erosion and ulcer.

3, Therapeutic Method:

One time 9 gram of oral medicine of the present invention, three times on the one, boiled water takes, and Chinese liquor draws for one glass.

4, criterion of therapeutical effect:

Produce effects: clinical symptoms and sign disappear, and it is normal that appetite is recovered.

Effectively: clinical symptoms and sign alleviate, and appetite increases.

Invalid: clinical symptoms and sign do not have any variation.

Worsen: sx or increase.

5, therapeutic outcome (seeing Table 2)

In a word, adopt stomach oral granule treatment acute or chronic gastritis 258 examples that heal, produce effects as a result, acute simple gastritis 8 examples, chronic superficial gastritis 98 examples, atrophic gastritis 48 examples, chronic hypertrophic gastritis 10 examples, obvious effective rate 63%, effectively: chronic superficial gastritis 36 examples, chronic atrophic gastritis 52 examples, chronic hypertrophic gastritis 5 examples, effective percentage is 36%.Invalid: chronic atrophic gastritis 2 examples, chronic hypertrophic gastritis 1 example, inefficiency are 1%.

Table 2 is observation of curative effect after treating

Come further to set forth the preparation method of medicine of the present invention by the following examples.

The heal preparation of oral granule of medicine stomach of the present invention:

Crusher for crushing is put in its Radix Aucklandiae (Radix Vladimiriae) 100 grams, Semen Litchi 100 grams, Placenta Hominis 200 gram mixing again, sieve, three times repeatedly, merge three medicated powder gained electuaries that sieve, wherein Placenta Hominis should hang earlier and tie up on the water tap, after big flood washes a night, put into the steaming of crib slow fire again, airing does not remove peplos.

Claims (2)

1, a kind of medicine for the treatment of gastritis is characterized in that being made by the raw material of following weight portion: Radix Aucklandiae (Radix Vladimiriae) 100 grams, Semen Litchi 100 grams, Placenta Hominis 200 grams.

2, according to the preparation method of the medicine of the described treatment gastritis of claim 1, it comprises the following steps:

A), weighting raw materials: Radix Aucklandiae (Radix Vladimiriae), Semen Litchi, Placenta Hominis;

B), crusher for crushing is put in Radix Aucklandiae (Radix Vladimiriae), Semen Litchi, the Placenta Hominis mixing of described weight proportion again, sieve, three times repeatedly, merge three medicated powder gained electuaries that sieve, wherein Placenta Hominis should hang earlier and tie up on the water tap, after big flood washes a night, put into the steaming of crib slow fire again, airing does not remove peplos.