CN106955348A - Chinese medicine composition and preparation method for treating chronic nephritis - Google Patents
Chinese medicine composition and preparation method for treating chronic nephritis Download PDFInfo
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- CN106955348A CN106955348A CN201710356585.4A CN201710356585A CN106955348A CN 106955348 A CN106955348 A CN 106955348A CN 201710356585 A CN201710356585 A CN 201710356585A CN 106955348 A CN106955348 A CN 106955348A
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Abstract
The present invention provides a kind of Chinese medicine composition and preparation method for being used to treat chronic nephritis, and the Chinese medicine composition is composed of the following components by mass percentage：Nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4%~6%, gingko 3%~5%, date 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, hawthorn 5%~7%, Gorgon fruit 5%~7%, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~7%, Radix Angelicae Sinensis 5%~7%.Will above-mentioned component mix after add water be boiled into after paste with maltodextrin and potassium sorbate mixing granulation, dry, sterilizing,.Chinese medicine of the present invention has clearing heat and detoxicating, tonifying speen and tonifying kidney, nourishing yin and nourishing blood, puckery smart diuresis, inducing diuresis for removing edema, the work(of blood circulation promoting and enriching；All there is very much good therapeutic effect to Urine proteins, blood urine, oedema, hypertension caused by chronic nephritis.
Description
Technical field
The invention belongs to the Chinese medicine composition of integration of drinking and medicinal herbs category, and in particular to a kind of Chinese medicine for being used to treat chronic nephritis
Composition and preparation method.
Background technology
Chronic nephritis is the abbreviation of CGN, is a kind of systemic disease based on renal lesions.It is clinical
It is the allergy occurred after body is infected hemolytic streptococcus using oedema, albuminuria, blood urine, hypertension as essential characteristic
Property disease.The cardinal symptom of chronic kidney disease has：Oedema, hypertension, pain over renal region and renal colic, urinary irritation (i.e. urgent urination, urine
Bitterly, frequent micturition), paruria (including hypourocrinia, albuminuria, blood urine, cylindruria, leukocyturia, pyuria and bacteruria, renal function
Test positive etc.).Patients with Chronic Renal Disease such as fails timely and effective treatment, delays with sb.'s illness took a turn for the worse, it is easy to develop into chronic
Renal insufficiency, kidney failure, or even form uremia, threat to life.
Modern medicine includes controlling blood pressure, the protein and antiplatelet that reduce in urine poly- for the treatment of chronic nephritis
Collection, hormone therapy etc., frequently with medicine have Dipyridamole, according to hormones such as lily magnolia, Valsartan, metacortandracin, prednisone, methylprednisolones
Class medicine carrys out symptom management, improves or alleviate clinical symptoms, prevents or delays renal function to continue to deteriorate.Hormone is covered to the state of an illness
Property stronger, easily recurrence, cure the symptoms, not the disease, get off to make patient to produce many complication for a long time.
Chronic nephritis belongs to the categories such as the traditional Chinese medical science " oedema ", " turbid urine ", " consumptive disease ", and the traditional Chinese medical science thinks that oedema is defeated mainly due to crystal
Caused by cloth imbalance, lung, spleen, kidney are the main organs during the defeated cloth of crystal, and it is marked on lung, and it is made in spleen, the fundamental cause of water disease being in the kidney.It is existing
The Chinese medicine of in the market treatment chronic nephritis is more to be cured the symptoms, not the disease, it is impossible to fundamentally cure chronic nephritis based on inducing diuresis to remove edema,
Therapeutic effect is simultaneously bad.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating chronic nephritis, using the treatment hand of solid decoction of medicinal ingredients
Section, for the treatment of chronic nephritis, can not only inducing diuresis to remove edema, and can also clearing heat and detoxicating, blood circulation promoting and enriching.
The technical solution adopted in the present invention is,
Chinese medicine composition for treating chronic nephritis, it is raw materials used composed of the following components by mass percentage：
Nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4%~6%, gingko 3%~
5%th, date 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, hawthorn 5%~7%, Gorgon fruit
5%~7%, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~7%, Radix Angelicae Sinensis 5%~
7%, the mass percent summation of above each component is 100%.
The above-mentioned preparation method for being used to treat chronic nephritis Chinese medicine composition, including following operating procedure：
Step 1,
By mass percentage, nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4% are weighed
~6%, gingko 3%~5%, date 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, mountain
Short, bristly hair or beard 5%~7%, Gorgon fruit 5%~7%, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~
7%th, Radix Angelicae Sinensis 5%~7%, the mass percent summation of above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time
The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, it is 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density,
Thick paste；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, the and of maltodextrin 73%~75.97% that step 2 is obtained are weighed
Potassium sorbate 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are stirred
To whitewashing, the weight ratio of thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, so
Pelletized afterwards toward whitewashing on mixed material, finally dry, cool, discharging, shutdown；
Step 6,
Last whole grain and filling, is produced.
In step 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h~25m3/
H, EAT is set to 80 DEG C~100 DEG C, heating premix is carried out to material 7~15 minutes, obtains mixed material；Premix is finished
Afterwards, it is then multifunctional fluidized bed to start by adjusting air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C
Whitewashing, spouting velocity is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, because material is aggravated after whitewashing,
Temperature is reduced, and air quantity is adjusted at any time and keeps material fully to jump, and regulation EAT makes temperature of charge be maintained at 35 DEG C at any time
~40 DEG C, whitewashing 15min~30min after close whitewashing, complete granulation；Multifunctional fluidized bed EAT is set to again
100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when the moisture≤2.0% of material, by EAT
25 DEG C~45 DEG C are down to, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
In step 6, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole
The dry particl of selection, is then fitted into bag and completes filling by grain.
The beneficial effects of the invention are as follows：Have clearing heat and detoxicating, tonifying speen and tonifying kidney, nourishing yin and nourishing blood, puckery smart diuresis, inducing diuresis for removing edema are living
The work(that blood is enriched blood；All there is very much good therapeutic effect to Urine proteins, blood urine, oedema, hypertension caused by chronic nephritis, and it is whole
Individual prescription scientific compatibility, the property of medicine is gentle, and human body is had no toxic side effect, can long-term taking.
Embodiment
The present invention provides a kind of Chinese medicine composition for being used to treat chronic nephritis, raw materials used by mass percentage by following
Component is constituted：
Nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4%~6%, gingko 3%~
5%th, date 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, hawthorn 5%~7%, Gorgon fruit
5%~7%, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~7%, Radix Angelicae Sinensis 5%~
7%, the mass percent summation of above each component is 100%.
The pharmacological action of Chinese medicine of the present invention is as follows：
Nutmeg：It is pungent, temperature, returns spleen stomach large intestine channel middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents, for deficiency-cold in spleen and stomach, endless diarrhea, gastral cavity abdomen
Distending pain, deficiency of food vomiting.
Emblic：Sweet, sour and astringent, cool, return lung stomach clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid, for blood-head blood stasis, disappears
Change bad, abdominal distension, cough, laryngalgia, dry.
Buddha's hand：It is pungent, bitter, acid, temperature, Return liver taste lung channel dispersing stagnated hepatoqi, and stomach and alleviating pain, it is eliminating dampness and eliminating phlegm, for stagnation of liver-QI and stomach-QI,
Distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, deficiency of food vomiting, coughing with a lot of sputum.
Brush-cherry seed：Pungent, bitter, sweet, flat returns spleen large intestine small intestinl channel relaxes bowel, lower gas Li Shui, for intestine-dryness due to consumption of fluid, dyspepsia gas
It is stagnant, abdominal distention constipation, oedema, tinea pedis, difficult urination.
Gingko：It is sweet, it is bitter, it is puckery, put down, poisonous, return lung kidney channel astringing lung for relieving asthma, stop-band contracting urine is breathed with cough for abundant expectoration, with lower white
It is turbid, enuresis frequent micturition.
Date：It is sweet, temperature, returns spleen stomach the heart channel of Hang-Shaoyin tonifying middle-Jiao and Qi, nourishing blood and tranquilization, for spleen eating less, weak loose stool, married woman is dirty
It is hot-tempered.
Rhizoma zingiberis：Nature and flavor acrid, bitter, warm, enters spleen, Liver Channel, and blood-breaking, promoting the circulation of qi is stimulated the menstrual flow, analgesic；For warming up spleen sun, malaria abdomen is controlled partially
Pain diarrhea, and energy Back to Yang Tongmai, Wenfei of drink are fainted inverse with four limbs, feeble and impalpable pulse, and cold drink cough and asthma, and the cold back of the body of shape is cold, and abundant expectoration is clear
It is dilute to wait disease.
Chinese yam：It is sweet, put down, return skin lung kidney channel tonifying spleen nourishing the stomach, engender liquid and benefic lung, for spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed heavily
Cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney；For spleen eating less, diarrhea loose stool, leukorrhea mistake
It is many.
Lotus seeds：Tonifying spleen and stopping diarrhea, stop-band, the puckery essence of kidney-nourishing, mental-tranquilization, for splenasthenic diarrhea, with, seminal emission, palpitation and insomnia.
Hawthorn：The sweet tepor returns spleen stomach Liver Channel food digesting stomach fortifying of acid, scattered stasis changes turbid lipid-loweringing.For meat stagnation, gastral cavilty is swollen
It is full, diarrhea dysentery abdominal pain, extravasated blood Amenorrhea, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Gorgon fruit：It is sweet puckery flat, returns spleen kidney channel supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, eliminating dampness and arresting leucorrhea, for emission and spermatorrhea, enuresis frequent micturition,
Under insufficiency of the spleen chronic diarrhea, gonorrhoea, band.
The fruit of Chinese wolfberry：Nourishing liver and kidney, benefiting shrewd head is used for consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, interior heat
Quench one's thirst, blood deficiency chlorosis, blurred vision.
Peach kernel：Promoting blood circulation, relaxes bowel, relieving cough and asthma, for amenorrhoea dysmenorrhoea, lung carbuncle acute appendicitis, injury from falling down, and intestinal dryness is just
It is secret, cough and asthma.
Radix Glycyrrhizae：It is sweet, put down.Thoughts of returning home lung taste are clearing heat and detoxicating through invigorating the spleen and benefiting qi, and remove phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription；
For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate medicine poison
Property is strong.
Poria cocos：Clearing damp and promoting diuresis, invigorating the spleen, calming heart, for oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind
Uneasiness, insomnia of palpitating with fear.
Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moistening dryness for relaxing bowels, for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, dysmenorrhoea is closed
Through asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sore wound, dry constipation of intestines.
According to《Chinese Pharmacopoeia》, Chinese yam tonifying spleen lung kidney qi in side, fruit of Chinese wolfberry nourishing kidney yin benefiting essence-blood, the two combination, gas is cloudy
Giving young employees remedial-courses in general knowledge and vocational skills, is altogether monarch.Gingko, lotus seeds, Gorgon fruit, sour and astringent convergence, controlling nocturnal emission with astringent drugs stop something lost, clearing heat and detoxicating, activating blood and eliminatng dampness；Nutmeg, Buddha's hand, Fu
Siberian cocklebur, brush-cherry seed, drying damp and strengthening spleen, smoothening secretion；Peach kernel, hawthorn, Radix Angelicae Sinensis, emblic, blood circulation promoting and enriching；Gingko, lotus seeds, Gorgon fruit, meat
Cardamom, Buddha's hand, Poria cocos, brush-cherry seed, peach kernel, hawthorn, Radix Angelicae Sinensis, emblic, are minister above.Rhizoma zingiberis, date, Radix Glycyrrhizae tonifying Qi are good for
Spleen, coordinating the drug actions of a prescription, for assistant.All medicines share, plays clearing heat and detoxicating, nourishing yin and nourishing blood, puckery smart diuresis, the effect of inducing diuresis for removing edema altogether.
Chinese medicine composition of the present invention is by the way of oral, oral 10 grams every time, 2 times a day, is within one month a course for the treatment of.
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
Preparation method for treating chronic nephritis Chinese medicine composition, including following operating procedure：
Step 1,
Weigh nutmeg 3kg, emblic 5kg, Buddha's hand 6kg, brush-cherry seed 5kg, gingko 3kg, date 4kg, rhizoma zingiberis 3kg, mountain
Medicine 13kg, lotus seeds 10kg, hawthorn 7kg, Gorgon fruit 6kg, fruit of Chinese wolfberry 12kg, peach kernel 5kg, Radix Glycyrrhizae 6kg, Poria cocos 5kg, Radix Angelicae Sinensis 7kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time
The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.35 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 20.5kg, maltodextrin 61.5kg and potassium sorbate 20g；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m3/ h, EAT is set
For 90 DEG C, heating premix is carried out to material 10 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome
Degree so that mixed material temperature reaches 36 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 17rpm, is atomized
Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time
Regulation EAT makes temperature of charge close whitewashing after being maintained at 36 DEG C, whitewashing 20min, completes granulation；Again by multi-functional fluidisation
The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤
When 2.0%, EAT is down to 25 DEG C, the temperature of material is reduced to 25 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will
The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 2
Preparation method for treating chronic nephritis Chinese medicine composition, including following operating procedure：
Step 1,
Weigh nutmeg 4kg, emblic 6kg, Buddha's hand 6kg, brush-cherry seed 4kg, gingko 3kg, date 6kg, rhizoma zingiberis 5kg, mountain
Medicine 12kg, lotus seeds 8kg, hawthorn 7kg, Gorgon fruit 6kg, fruit of Chinese wolfberry 12kg, peach kernel 4kg, Radix Glycyrrhizae 4kg, Poria cocos 6kg, Radix Angelicae Sinensis 7kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time
The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.20 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24kg, maltodextrin 75.97kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing,
The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 25m3/ h, EAT is set
For 80 DEG C, heating premix is carried out to material 7 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome
Degree so that mixed material temperature reaches 40 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 15rpm, is atomized
Pressure is 1.50bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time
Regulation EAT makes temperature of charge close whitewashing after being maintained at 40 DEG C, whitewashing 15min, completes granulation；Again by multi-functional fluidisation
The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤
When 2.0%, EAT is down to 35 DEG C, the temperature of material is reduced to 35 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will
The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 3
Preparation method for treating chronic nephritis Chinese medicine composition, including following operating procedure：
Step 1,
Weigh nutmeg 5kg, emblic 6kg, Buddha's hand 4kg, brush-cherry seed 6kg, gingko 4kg, date 5kg, rhizoma zingiberis 5kg, mountain
Medicine 12kg, lotus seeds 9kg, hawthorn 5kg, Gorgon fruit 5kg, fruit of Chinese wolfberry 13kg, peach kernel 5kg, Radix Glycyrrhizae 5kg, Poria cocos 6kg, Radix Angelicae Sinensis 5kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time
The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.30 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 26.97kg, maltodextrin 73kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing,
The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h, EAT is set
For 100 DEG C, heating premix is carried out to material 12 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome
Degree so that when mixed material temperature reaches 38 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 18rpm, mist
Change pressure is 2.0bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and with
When regulation EAT temperature of charge is maintained at 38 DEG C, close whitewashing after whitewashing 30min, complete granulation；Again by multi-functional stream
The EAT of change bed is set to 100 DEG C and material is dried, and regulation air quantity keeps material fully to jump, when the moisture of material
When≤2.0%, EAT is down to 30 DEG C, the temperature of material is reduced to 30 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will
The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 4
Preparation method for treating chronic nephritis Chinese medicine composition, including following operating procedure：
Step 1,
Weigh nutmeg 5kg, emblic 7kg, Buddha's hand 5kg, brush-cherry seed 4kg, gingko 5kg, date 6kg, rhizoma zingiberis 4kg, mountain
Medicine 11kg, lotus seeds 8kg, hawthorn 6kg, Gorgon fruit 7kg, fruit of Chinese wolfberry 11kg, peach kernel 3kg, Radix Glycyrrhizae 5kg, Poria cocos 7kg, Radix Angelicae Sinensis 6kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time
The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.40 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24.02kg, maltodextrin 75.97kg and potassium sorbate 10g；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m3/ h, EAT is set
For 95 DEG C, heating premix is carried out to material 15 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome
Degree so that mixed material temperature reaches 35 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 20rpm, is atomized
Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time
Regulation EAT makes temperature of charge close whitewashing after being maintained at 35 DEG C, whitewashing 25min, completes granulation；Again by multi-functional fluidisation
The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤
When 2.0%, EAT is down to 45 DEG C, the temperature of material is reduced to 45 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will
The dry particl of selection, which is fitted into bag, completes filling.
Clinical data：
1st, case selection：
In order to verify the effect of pharmaceutical composition of the present invention, in December, -2016 in June, 2015, the chronic renal made a definite diagnosis is selected
Scorching 180 clinical observations of patient, male 88, women 92, age 25-62 Sui, average age 34.2 years old, the course of disease 4 months~8
Year, average course of disease 5.4 years.
Diagnostic criteria：The course of disease more than 3 months, the albuminuria and/or blood urine of long duration, long-term oedema, hypertension, and
With slight kidney function damage.
Exclude infection, calculus, allergy and diabetes, systemic loupus erythematosus, anaphylactoid purpura, renal amyloidosis, tumour
Etc. Secondary cases nephrosis caused by secondary factor, and exclude patients with renal failure.
2nd, medicament selection：
Patient takes medicine of the present invention, and 2 times a day, each 10g, warm water delivery service in half an hour after meal, is within 30 days a treatment
Journey, continuously takes 2 to 5 courses for the treatment of, and the person of being in a bad way follows the doctor's advice increase at discretion consumption.
3rd, efficacy determination：
(1) cure：Routine urianlysis Urine proteins are turned out cloudy or twenty-four-hour urine protein quantification is normal；Routine urinalysis red blood cell count(RBC) is just
Often；Normal renal function；The various symptoms such as oedema, hypertension disappear.
(2) it is effective：Routine urianlysis Urine proteins reduce by 2 "+" or twenty-four-hour urine protein quantification reduces >=40%；Routine urinalysis
Red blood cell count(RBC) reduces by >=3/HP；Normal renal function is normal；The various symptoms such as oedema, hypertension have clear improvement.
(3) effectively：Routine urianlysis Urine proteins reduce by 1 "+" or twenty-four-hour urine protein quantification reduces ＜ 40%；Routine urinalysis
Red blood cell count(RBC) reduces 3/HP of ＜；Renal function makes moderate progress；The various symptoms such as oedema, hypertension take a favorable turn.
(4) it is invalid：Urine proteins, red blood cell count(RBC), renal function without improvement or are aggravated；The various symptoms such as oedema, hypertension
It is not improved, or even aggravates or deteriorate.
4th, result：
In the treatment group for taking medicine of the present invention, 77 are cured, effective 52, effective 30, invalid 21, cure rate is
42.8%, total effective rate 88.3%.
5. observation index：
Observe twenty-four-hour urine protein quantification (PRO), routine urinalysis red blood cell (RBC) counting, serum creatinine (Scr), blood urea nitrogen
(BUN), endogenous creatinine clearance rate (Ccr) index changes, and its result is as shown in table 1：
Table 1 treats front and rear PRO, urine RBC, Scr, BUN, Ccr
Case 1
The Mr. Wang, male of Shaanxi Province's Ankang City, 48 years old；Started the puffiness of the eyes before 2 months, after then four limbs anasarca, skin
Floodlight pool, by depression rise again immediately；With symptoms such as heating, pharyngalgia, coughs；Thin white fur of tongue, floating pulse or number；Urine examination albumen (+
++), leucocyte (++), red blood cell (+)；Blood routine WBC, urea nitrogen, serum creatinine, total serum protein, albumin and globulin are equal
It is abnormal；Take after Chinese medicine of the present invention, daily two doses (one 10g), 2 courses for the treatment of, symptom is clearly better, continue to take 2 courses for the treatment of,
Symptom is wholly absent, and repeatedly check routine urinalysis, blood routine and renal function are normal, to consolidate curative effect, then take a course for the treatment of.
Case 2
Cai in Xi'an City, Shanxi Province Hu County, female, 50 years old；Edema is more acute when medical, and skin stretches tight urgency, the big turgor of abdomen, uncomfortable in chest
Dysphoria with smothery sensation, with dry, scanty drak urine, dry and hard excrement；Tongue is red, yellow and greasy fur, thready,rolling and rapid pulse；After testing：Blood uric acid 456.3mmol/L,
Creatinine 397.9mmol/L, urea nitrogen 25.5mmol/L；Urinalysis：Leucocyte 233.5/ul, red blood cell 104.7/ul, urinate egg
White 3+；Take after Chinese medicine of the present invention, daily two doses (one 10g), 3 courses for the treatment of, symptom is clearly better, after testing：Blood uric acid
405.2mmol/L, creatinine 310.2mmol/L, urea nitrogen 11.3mmol/L, routine urinalysis are normal, and various symptoms are clearly better, and continue
2 courses for the treatment of are taken, various symptoms are wholly absent, repeatedly check routine urinalysis, blood routine and renal function are normal, recovery from illness.
Case 3
The Zhang of Shaanxi Province Weinan City Fuping County, 54 years old, female；Medical readme：Puffiness of the face and limbs, repeatedly growth and decline, Lao Houhuo noons
After aggravate, swollen indigestion and loss of appetite with gastral cavity, sallow complexion, tired weak, the oliguria color of god are clear, stool or half congealed, and white and slippery fur, arteries and veins is thin and delicate；After testing：
High blood pressure has intermediate edema up to 100~160mmHg, and blood routine shows anaemia, and routine urinalysis shows Urine proteins (2+), occult blood (2
+), renal function is shown, uric acid 640 μm of ol/L, blood urea nitrogen 15.32mmol/L, 220 μm of ol/L of creatinine, and twenty-four-hour urine albumen is determined
1.45g/24h is measured, and urine volume only has 980ml.Take daily two doses (one 10g) after this formula, after 3 courses for the treatment of, routine urinalysis shows
Showing the index of albumen and occult blood has the trend turned out cloudy, and renal function shows uric acid reduction, and creatinine and blood urea nitrogen change are little, and 24
Hour quantity of proteinuria is reduced, and urine volume, which increases, arrives 1400ml.Continue to take 2 courses for the treatment of, the mental status and appetite of patient have substantially
Take a turn for the better, edema disappears, blood pressure drops to 70~120mmHg, routine urinalysis shows that Urine proteins are turned out cloudy, and occult blood (+), uric acid is reduced to 256 μ
Mol/L, blood urea nitrogen 9.07mmol/L, creatinine 138.49 μm of ol/L, twenty-four-hour urine protein quantification 0.52g/24h, twenty-four-hour urine
Measure 1500ml.
Case 4
The Zheng of Shaanxi Province's Yulin City, 62 years old, man；When medical：Edema of pair of lower extremities, the big fullness sensation in chest of abdomen, sleeping then syndrome characterized by dyspnea；It is tired with god
Chilly, pale complexion is received less, urine is deficient；Pale tongue is fat, side print with teeth, and tongue is white, and arteries and veins is thin and delicate.Once drug administration was treated, only slight
Alleviate.After testing：Urine proteins (2+), occult blood (2+), twenty-four-hour urine protein quantification 1.28g/24h；Chinese medicine of the present invention is taken, daily
After two doses (one 10g), 3 courses for the treatment of, symptom substantially mitigates, after testing：Urine proteins (+), occult blood (+), twenty-four-hour urine albumen is determined
0.76g/24h is measured, the state of an illness is clearly better, patient's edema extinction, feed takes a turn for the better, the state of mind is also clearly better, and other symptoms are bright
It is aobvious to mitigate；Continue to take 2 courses for the treatment of, routine urinalysis, blood routine, renal function are normal, symptom disappears, cure.
Claims (4)
1. the Chinese medicine composition for treating chronic nephritis, it is characterised in that raw materials used by mass percentage by following components
Composition：
It is nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4%~6%, gingko 3%~5%, big
Jujube 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, hawthorn 5%~7%, Gorgon fruit 5%~
7%th, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~7%, Radix Angelicae Sinensis 5%~7%, the above
The mass percent summation of each component is 100%.
2. be used to treat the preparation method of chronic nephritis Chinese medicine composition described in a kind of claim 1, it is characterised in that including with
Lower operating procedure：
Step 1,
By mass percentage, weigh nutmeg 3%~5%, emblic 5%~7%, Buddha's hand 4%~6%, brush-cherry seed 4%~
6%th, gingko 3%~5%, date 4%~6%, rhizoma zingiberis 3%~5%, Chinese yam 11%~13%, lotus seeds 8%~10%, hawthorn
5%~7%, Gorgon fruit 5%~7%, the fruit of Chinese wolfberry 11%~13%, peach kernel 3%~5%, Radix Glycyrrhizae 4%~6%, Poria cocos 5%~
7%th, Radix Angelicae Sinensis 5%~7%, the mass percent summation of above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of 10 times of amounts are added for the first time, are decocted 2 hours, second plus 6 times
The water of amount, is decocted 2 hours, merges decocting liquid twice, filtering, it is the thick of 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density,
Cream；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, maltodextrin 73%~75.97% and sorb that step 2 is obtained are weighed
Sour potassium 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are uniformly mixing to obtain spray
The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, it is then past
Whitewashing is pelletized on mixed material, is finally dried, cools, discharges, is shut down；
Step 6,
Last whole grain and filling, is produced.
3. it is used for the preparation method for treating chronic nephritis Chinese medicine composition according to claim 2, it is characterised in that：The step
In rapid 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h~25m3/ h, EAT
80 DEG C~100 DEG C are set to, heating premix is carried out to material 7~15 minutes, mixed material is obtained；After premix is finished, by adjusting
Save air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, it is then multifunctional fluidized bed to start whitewashing, whitewashing
Speed is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, because material is aggravated after whitewashing, temperature reduction,
Regulation air quantity keeps material fully to jump at any time, and regulation EAT makes temperature of charge be maintained at 35 DEG C~40 DEG C, spray at any time
Starch and whitewashing is closed after 15min~30min, complete granulation；Multifunctional fluidized bed EAT is set to 100 DEG C to material again
Be dried, regulation air quantity keeps material fully to jump, when the moisture≤2.0% of material, by EAT be down to 25 DEG C~
45 DEG C, the temperature of material is set to be reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
4. it is used for the preparation method for treating chronic nephritis Chinese medicine composition according to claim 2, it is characterised in that：The step
In rapid 6, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will choosing
The dry particl taken, which is fitted into bag, completes filling.
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| CN108567874A (en) * | 2018-07-09 | 2018-09-25 | 湖南橘色科技有限责任公司 | A kind of tonifying speen and tonifying kidney composition and preparation method thereof |
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| CN106511721A (en) * | 2016-12-28 | 2017-03-22 | 陕西红顶名医堂药业有限公司 | Traditional Chinese medicine composition used for treating chronic rhinitis and preparing method of traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106511721A (en) * | 2016-12-28 | 2017-03-22 | 陕西红顶名医堂药业有限公司 | Traditional Chinese medicine composition used for treating chronic rhinitis and preparing method of traditional Chinese medicine composition |
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| CN108567874A (en) * | 2018-07-09 | 2018-09-25 | 湖南橘色科技有限责任公司 | A kind of tonifying speen and tonifying kidney composition and preparation method thereof |
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