CN108478683B - Beverage for postoperative gas exhaust - Google Patents
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K2236/30—Extraction of the material
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Abstract
The invention belongs to the field of traditional Chinese medicines, and relates to a beverage for postoperative gas exhaustion. The beverage is prepared from the following raw material medicines in parts by weight: 5-15g of fried radish seed, 10-20g of dried orange peel, 10-20g of hawthorn, 10-20g of Chinese yam, 10-20g of Chinese date and 10-20g of fried cassia seed. The beverage can be used for patients with postoperative gas exhaustion.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a beverage for postoperative gas exhaustion and a preparation method thereof.
Background
Flatulence is a very common symptom after surgery and is associated with gastrointestinal dysfunction. During the operation, the gastrointestinal tract of the patient is exposed and has certain irritation; meanwhile, stimulation may be generated to different degrees in the operation process, so that gastrointestinal tract function is reduced, peristalsis is weakened, and flatulence is further caused. It is mainly manifested as abdominal distension and failure to normally exhaust. The incidence of patients who need to be bedridden after operation is higher. Some patients can relieve their symptoms by themselves, but some patients still have various other complications, which affect the recovery of the patients and are not beneficial to disease recovery. Therefore, timely treatment of the disease is very necessary for the patient.
Disclosure of Invention
The invention aims to solve the technical problem that a patient is difficult to exhaust after an operation, and provides a beverage for exhausting after the operation and a preparation method thereof.
A beverage for postoperative gas exhaust is prepared from the following raw material medicines in parts by weight: 5-15g of fried radish seed, 10-20g of dried orange peel, 10-20g of hawthorn, 10-20g of Chinese yam, 10-20g of Chinese date and 10-20g of fried cassia seed.
A beverage for postoperative gas exhaust is prepared from the following raw material medicines in parts by weight: 10g of fried radish seed, 16g of dried orange peel, 16g of hawthorn, 16g of Chinese yam, 16g of Chinese date and 16g of fried cassia seed.
A method for preparing beverage for postoperative gas discharge comprises extracting parched Raphani semen, pericarpium Citri Tangerinae, fructus crataegi, rhizoma Dioscoreae, fructus Jujubae, parched semen Cassiae, etc. with 18 times of water twice, mixing extractive solutions, concentrating, adding 14ml Mel, and diluting to volume of 200ml, the concentration is 0.45 g.mL-1。
The effects of the raw materials are as follows:
frying radish seeds: pungent, sweet and neutral. It enters spleen, stomach, lung and large intestine meridians. Promote digestion, remove food stagnation, direct adverse flow of qi downward and resolve phlegm. Can be used for treating dyspepsia, abdominal distention, diarrhea, dysentery with tenesmus, cough with excessive phlegm, adverse flow of qi, and dyspnea with fullness.
Dried orange peel: pungent, bitter and warm in property, enter spleen, stomach and lung meridians. Regulate qi, check adverse rise of qi, arrest vomiting, dry dampness and resolve phlegm. Can be used for treating fullness and stuffiness of chest and diaphragm, abdominal distention and pain, anorexia, emesis, etc.
Hawthorn fruit: sour, sweet and slightly warm. It enters spleen, stomach and liver meridians. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating food stagnation, abdominal distention and pain, diarrhea, dysentery, hernia, and swelling and pain.
Chinese yam: sweet and neutral. It enters spleen, lung and kidney meridians. Tonify qi, nourish yin, tonify spleen, lung and kidney, secure essence and stop leukorrhagia. Can be used for treating spleen and stomach deficiency, lung and kidney deficiency, internal heat due to yin deficiency, thirst, polydipsia, and frequent micturition.
Chinese date: sweet and warm. It enters spleen and stomach meridians. Tonify middle-jiao and Qi, nourish blood and soothe the nerves, and alleviate the property of the medicine. Can be used for treating spleen deficiency, anorexia, loose stool, listlessness, debilitation, blood deficiency, sallow complexion, female viscera, uneasiness, and protecting vital qi
Parching semen Cassiae: salty and bitter, cool and nontoxic. Dispel wind, clear heat, remove toxicity and promote diuresis. The traditional Chinese medicine composition is clinically used for treating wind-heat type cold, influenza, acute conjunctivitis, damp-heat type jaundice, acute and chronic nephritis, leucorrhea, scrofula, sores, carbuncle, furuncle, mastitis and other diseases.
The following experimental research verifies that the invention achieves unexpected technical effects:
the medicine of the invention is used for experimental research of abdominal exhaust
1 data and method
1.1 Experimental materials
The method comprises the steps of selecting Kunming mice with half male and half female, weighing 18-22 g and provided by the animal center of Shandong Chinese medicine university. License number: (scxk (lu) 20130009).
1.2 instruments and reagents
Preparing a nutrient paste by using an electronic analytical balance (Mettler company), CMC-Na4g, 8g of milk powder, 4g of sugar, 4g of starch, 1.5g of activated carbon and 125mL of distilled water, and measuring the density of the nutrient paste to be 1.02 g/mL-1。
1.3 test drugs
(1) The beverage of the invention: 10g of fried radish seed, 16g of dried orange peel, 16g of hawthorn, 16g of Chinese yam, 16g of Chinese date and fried cassia seed16g of semen cassiae, 18 times of water is added for extracting twice, the extracting solution is mixed and concentrated, 14ml of honey is added, the volume is determined to be 200ml, and the concentration is equivalent to 0.45 g/ml of raw medicinal materials-1。
(2) Comparative pharmaceutical composition 1: 18g of dried orange peel, 18g of hawthorn, 18g of Chinese yam, 18g of Chinese date and 18g of fried cassia seed, adding 18 times of water to extract twice, mixing the extracting solution, concentrating, adding 14ml of honey, and fixing the volume to 200ml, wherein the concentration is equivalent to 0.45g-1。
(3) Comparative pharmaceutical composition 2: 12.2g of fried radish seed, 19.45g of hawthorn, 19.45g of yam, 19.45g of Chinese date and 19.45g of fried cassia seed are extracted twice by adding 18 times of water, mixed extracting solution is concentrated, 14ml of honey is added, the volume is constant to 200ml, and the concentration is equivalent to 0.45 g/ml of original medicinal material-1。
(4) Comparative pharmaceutical composition 3: 12.2g of fried radish seed, 19.45g of dried orange peel, 19.45g of Chinese yam, 19.45g of Chinese date and 19.45g of fried cassia seed are extracted twice by adding 18 times of water, mixed extracting solution is concentrated, 14ml of honey is added, the volume is constant to 200ml, and the concentration is equivalent to 0.45 g/ml of original medicinal material-1。
(5) Comparative pharmaceutical composition 4: 12.2g of fried radish seed, 19.45g of dried orange peel, 19.45g of hawthorn, 19.45g of Chinese date and 19.45g of fried cassia seed are extracted twice by adding 18 times of water, mixed extracting solution is concentrated, 14ml of honey is added, the volume is constant to 200ml, and the concentration is equivalent to 0.45 g/ml of original medicinal material-1。
(6) Comparative pharmaceutical composition 5: 12.2g of fried radish seed, 19.45g of dried orange peel, 19.45g of hawthorn, 19.45g of Chinese yam and 19.45g of fried cassia seed are extracted twice by adding 18 times of water, mixed extracting solution is concentrated, 14ml of honey is added, the volume is fixed to 200ml, and the concentration is equivalent to 0.45 g/ml of original medicinal material-1。
(7) Comparative pharmaceutical composition 6: 12.2g of fried radish seed, 19.45g of dried orange peel, 19.45g of hawthorn, 19.45g of Chinese yam and 19.45g of Chinese date are extracted twice by adding 18 times of water, mixed extract is concentrated, 14ml of honey is added, the volume is fixed to 200ml, and the concentration is equivalent to 0.45 g.mL of original medicinal material-1。
(8) Comparative pharmaceutical composition 7: magnolia officinalis air-exhausting mixture (Ruiyang pharmaceutical Co., Ltd., national drug standard Z200505)63) The prepared concentration is 0.45 g.mL which is equivalent to the original medicinal material-1。
(9) Control group 8: the same amount of distilled water was taken as a control.
1.4 Experimental methods
Influence on gastric emptying and intestinal propulsion of in vivo mice
(1) Determination of the dose to be administered
The volume of the test solution in the large dose group was 0.03mL per mouse, calculated on the body surface area, taking into account the losses during the extraction and isolation process. The administration dose is 4 times, 6 times, 8 times and 10 times of the large dose of 18 mice (2 mice/group) respectively through a preliminary test, each mouse has no abnormal reaction, and the administration dose is finally determined to be 0.3 ml.
(2) Method of producing a composite material
108 Kunming mice, half male and half female, were randomly divided into the beverage group of the present invention, the comparative drug group 1-7, and the control group 8, for a total of 9 groups, each group consisting of 12 mice. Mice were fasted for 24h prior to the experiment, during which time water was freely available. By adopting a gastric perfusion method, the concentration of the animals in the experimental group is respectively irrigated with the gastric lavage liquid to be 0.45 g.mL-1The beverage of the invention is 0.3mL, the concentration of the contrast drug group 7 is 0.45 g.mL-1Cortex Magnolia officinalis exhaust liquid 0.3ml, and control group is infused with distilled water 0.3 ml. After the administration of lh, the semisolid nutrient paste was administered, 0.4mL each, and the cervical vertebrae were removed and sacrificed after 20 min. Ligature stomach cardia and pylorus, weighing stomach to obtain total weight of stomach, cutting stomach body along greater curvature of stomach, washing off stomach content, wiping and weighing to obtain net weight of stomach. The difference value of the total weight and the net weight of the stomach is the weight of residues in the stomach, and the percentage of the residues in the stomach, which account for the weight of the filled semisolid paste, is the residue rate in the stomach. At the same time, the small intestine was quickly removed, gently peeled off and laid on white paper, and the distance from the pylorus to the full length of the ileocecal section and the distance from the pylorus to the front of the black semisolid paste were measured. The small intestine propulsion rate is the percentage of the distance from the pylorus to the front of the black semisolid paste (propulsion length) to the total length from the pylorus to the ileocecal part (total length of the small intestine).
The residual rate in stomach is (total weight of stomach-net weight)/weight of filled nutrient paste is multiplied by 100 percent
The small intestine propulsion rate is the propulsion length/the total length of the small intestine is multiplied by 100 percent
(3) Results of the experiment
Experimental results analysis software: SPSS 13.0
TABLE 1 Effect of the beverages of the invention on gastric emptying in mice: (
±s , n =12)
Note that a: compared with a control group, the difference is significant, and the P is less than 0.01; b: p <0.05, significant difference compared to control drug group 7; c: compared with the beverage group, the difference is significant, and the P is less than 0.05.
TABLE 2 Effect of the beverages of the invention on intestinal propulsion in mice: (
±s , n =12)
Note that a: compared with a control group, the difference is significant, and the P is less than 0.01; b: compared with the comparative drug group 7, the difference is significant when P is less than 0.05, and c: compared with the beverage group, the difference is significant, and the P is less than 0.05.
The experimental results show that: the drink group has significant difference in the gastric residual rate and the intestinal propulsion aluminum compared with the control group and the comparative drug group, has obvious propulsion function, and can obviously enhance the intestinal propulsion of mice.
1.5 conclusion
The beverage group of the invention can obviously promote the gastric emptying of mice and enhance the small intestine propelling force. The post-operative exhaust beverage disclosed by the invention is perfectly matched in medicinal flavor composition and dosage, has an obvious synergistic interaction effect, can greatly reduce the overall curative effect of the pharmaceutical composition due to the absence of any one medicine, and has a good effect on post-operative exhaust patients.
Detailed Description
1. For exhausting after operationThe beverage is prepared from the following raw material medicines in parts by weight: the preparation method comprises the steps of taking raw material medicines, adding 18 times of water to extract twice, mixing the extract, concentrating, adding 14mL of honey, fixing the volume to 200mL, wherein the concentration is equivalent to 0.45 g/mL of the raw material medicines-1。
2. A beverage for postoperative gas exhaust is composed of the following raw material medicines in parts by weight: the preparation method comprises the steps of taking 10g of fried radish seeds, 16g of dried orange peel, 16g of hawthorn, 16g of Chinese yam, 16g of Chinese date and 16g of fried cassia seeds, extracting the raw materials twice by adding 18 times of water, mixing the extracting solution, concentrating, adding 14mL of honey, and fixing the volume to 200mL, wherein the concentration is equivalent to 0.45 g/mL of the raw materials-1。
3. A beverage for postoperative gas exhaust is composed of the following raw material medicines in parts by weight: 15g of fried radish seed, 15g of dried orange peel, 15g of hawthorn, 15g of Chinese yam, 15g of Chinese date and 15g of fried cassia seed, and the preparation method comprises the steps of taking the raw materials, adding 18 times of water to extract twice, mixing the extract, concentrating, adding 14mL of honey, and fixing the volume to 200mL, wherein the concentration is equivalent to 0.45 g/mL of the raw materials-1。。
Claims (3)
1. A beverage for post-operative venting, characterized by: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 5-15g of fried radish seed, 10-20g of dried orange peel, 10-20g of hawthorn, 10-20g of Chinese yam, 10-20g of Chinese date and 10-20g of fried cassia seed, and the preparation method comprises the following steps: extracting the raw materials with 18 times of water twice, mixing the extractive solutions, concentrating, adding 14ml of Mel, and diluting to 200ml with a volume equivalent to 0.45g of raw materials per ml.
2. The beverage for post-operative venting of gas according to claim 1, wherein: the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 10g of fried radish seed, 16g of dried orange peel, 16g of hawthorn, 16g of Chinese yam, 16g of Chinese date and 16g of fried cassia seed.
3. The method for preparing a beverage for post-operative venting according to claim 1 or 2, characterized in that: extracting the raw materials with 18 times of water twice, mixing the extractive solutions, concentrating, adding 14ml of Mel, and diluting to 200ml with a volume equivalent to 0.45g of raw materials per ml.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810261135.1A CN108478683B (en) | 2018-03-28 | 2018-03-28 | Beverage for postoperative gas exhaust |
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| CN201810261135.1A CN108478683B (en) | 2018-03-28 | 2018-03-28 | Beverage for postoperative gas exhaust |
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| CN108478683B true CN108478683B (en) | 2020-11-17 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1138990A (en) * | 1995-06-27 | 1997-01-01 | 郑铁保健食品厂 | Oral liquid for preventing and curing infantile anorexia and its prepn |
| CN1754453A (en) * | 2004-09-30 | 2006-04-05 | 刘滨德 | Health food with function of promoting and eliminating indigestion, mositurizing bowel and defaecation |
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2018
- 2018-03-28 CN CN201810261135.1A patent/CN108478683B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1138990A (en) * | 1995-06-27 | 1997-01-01 | 郑铁保健食品厂 | Oral liquid for preventing and curing infantile anorexia and its prepn |
| CN1754453A (en) * | 2004-09-30 | 2006-04-05 | 刘滨德 | Health food with function of promoting and eliminating indigestion, mositurizing bowel and defaecation |
Non-Patent Citations (1)
| Title |
|---|
| 茯苓对正常小鼠胃肠功能的影响;冉小库等;《中国现代中药》;20150731;第17卷(第7期);第686-689页 * |
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