CN108478683A - A kind of beverage for final vacuum of performing the operation - Google Patents

A kind of beverage for final vacuum of performing the operation Download PDF

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Publication number
CN108478683A
CN108478683A CN201810261135.1A CN201810261135A CN108478683A CN 108478683 A CN108478683 A CN 108478683A CN 201810261135 A CN201810261135 A CN 201810261135A CN 108478683 A CN108478683 A CN 108478683A
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Prior art keywords
beverage
final vacuum
concentration
jujube
hawthorn
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CN201810261135.1A
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CN108478683B (en
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于鹏飞
曲远均
李钦刚
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Qingdao Pusheng Runbang Pharmaceutical Technology Co.,Ltd.
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Qingdao Xinli Biological Science And Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the field of Chinese medicines, are related to a kind of beverage for final vacuum of performing the operation.The beverage is prepared by the bulk pharmaceutical chemicals of following parts by weight:5 15g of stir-baked SEMEN RAPHANI, 10 20g of dried orange peel, 10 20g of hawthorn, 10 20g of Chinese yam, 10 20g of jujube, 10 20g of fried cassia are made.The beverage can be used for the patient of operation final vacuum.

Description

A kind of beverage for final vacuum of performing the operation
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of beverage for final vacuum of performing the operation and its preparation side Method.
Background technology
Flatulence is very common symptom after operation, extremely related with gastrointestinal function.In surgical procedure, the gastrointestinal tract of patient Exposure, has it certain irritation;Meanwhile different degrees of stimulation may be generated in operative process to it, so as to cause Gastrointestinal function declines, wriggling reduced capability, and then causes flatulence.It is mainly shown as abdominal distension, is unable to normal exhaust.Postoperative need The patient morbidity's higher to be liied in bed.The symptom of some patientss can voluntarily be alleviated, but still there have some patientss that can occur to be various other Complication, influence patient more after, be unfavorable for disease recovery.Therefore, it is very necessary to patient that the disease is treated in time.
Invention content
The technical problem to be solved by the present invention is to patient's operation final vacuum hardly possiblies, provide a kind of beverage for final vacuum of performing the operation And preparation method thereof.
A kind of beverage for final vacuum of performing the operation, it is prepared by the bulk pharmaceutical chemicals of following parts by weight:Stir-baked SEMEN RAPHANI 5-15g, dried orange peel 10-20g, hawthorn 10-20g, Chinese yam 10-20g, jujube 10-20g, the sub- 10-20g of fried cassia.
A kind of beverage for final vacuum of performing the operation, it is prepared by the bulk pharmaceutical chemicals of following parts by weight:Stir-baked SEMEN RAPHANI 10g, dried orange peel 16g, hawthorn 16g, Chinese yam 16g, jujube 16g, the sub- 16g of fried cassia.
A kind of preparation method of beverage for final vacuum of performing the operation, takes stir-baked SEMEN RAPHANI, dried orange peel, hawthorn, Chinese yam, jujube, stir-fry The bulk pharmaceutical chemicals such as cassia seed add 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration It is 0.45g mL to be equivalent to crude drug-1
Each bulk pharmaceutical chemicals effect is as follows:
Stir-baked SEMEN RAPHANI:It is pungent, sweet, flat.Returns spleen, stomach, lung, large intestine channel.Promoting digestion, lowering the adverse-rising QI and eliminating phlegm.For stagnation of QI due to dyspepsia, gastral cavity abdomen is swollen Expire, diarrhea, weight after diarrhea, cough ant phlegm, circulation of vital energy in the wrong direction asthma is full etc..
Dried orange peel:Acrid, bitter, warm, returns spleen, stomach, lung channel.In qi-regulating tune, stopping nausea and vomiting by lowering the adverse flow of QI is eliminating dampness and eliminating phlegm.For chest and diaphragm expire vexed, gastral cavity Abdominal distention and pain, do not feel like eating, vomiting etc..
Hawthorn:Sour, sweet, tepor.Returns spleen, stomach, Liver Channel.Food digesting stomach fortifying, scattered stasis.For eating accumulation, abdominal distention, Dysentery, hernia swelling and pain etc..
Chinese yam:It is sweet, flat.Returns spleen, lung, kidney channel.Supplementing qi and nourishing yin, tonifying spleen lung kidney, treating spontaneous emission and leukorrhagia.For weakness of the spleen and stomach, lung The weak card of kidney deficiency, yin asthenia generating intrinsic heat, polydipsia, the diabete of frequent urination.
Jujube:It is sweet, warm.Returns spleen, stomach.Tonifying middle-Jiao and Qi, nourishing blood and tranquilization mitigate pharmacological property.For spleen eating less loose stool, burnout Weak, blood deficiency chlorosis and women's internal organs, mind is uneasy, protection healthy tendency etc.
Fried cassia:Salty hardship, Pingliang are nontoxic.Expelling wind and clearing away heat, detoxification and promoting urination.It is clinically used for anemopyretic cold, influenza, acute conjunctiva Inflammation, jaundice with damp-heat pathogen, acute and chronic nephritis, under, scrofula, sore carbuncle furuncle, the diseases such as mastitis.
Invention achieves unexpected technique effects for research verification through the following experiment:
Drug of the present invention is used for the experimental study of abdomen exhaust
1 data and method
1.1 experiment material
Kunming mouse, half male and half female, 18~22g of weight, Shandong Traditional Chinese Medicine University's animal center offer are provided.Credit number: (scxk (Shandong) 20130009).
1.2 instruments and reagent
Electronic analytical balance(Mei Tele companies), CMC-Na4g, milk powder 8g, sugared 4g, starch 4g, activated carbon 1.5g, distillation Water 125mL is made into nutrition paste, measures nutrition paste density 1.02gmL-1
1.3 test medicine
(1)Beverage of the present invention:Stir-baked SEMEN RAPHANI 10g, dried orange peel 16g, hawthorn 16g, Chinese yam 16g, jujube 16g, the sub- 16g of fried cassia, add Twice, mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration is equivalent to crude drug and is for 18 times of amount water extractions 0.45g•mL-1
(2)Drugs compared composition 1:Dried orange peel 18g, hawthorn 18g, Chinese yam 18g, jujube 18g, the sub- 18g of fried cassia, add 18 Twice, mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration is equivalent to crude drug and is the extraction of amount water again 0.45g•mL-1
(3)Drugs compared composition 2:Stir-baked SEMEN RAPHANI 12.2g, it hawthorn 19.45g, Chinese yam 19.45g, jujube 19.45g, fries Cassia seed 19.45g adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration phase When in crude drug be 0.45g mL-1
(4)Drugs compared composition 3:Stir-baked SEMEN RAPHANI 12.2g, it dried orange peel 19.45g, Chinese yam 19.45g, jujube 19.45g, fries Cassia seed 19.45g adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration phase When in crude drug be 0.45g mL-1
(5)Drugs compared composition 4:Stir-baked SEMEN RAPHANI 12.2g, it dried orange peel 19.45g, hawthorn 19.45g, jujube 19.45g, fries Cassia seed 19.45g adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration phase When in crude drug be 0.45g mL-1
(6)Drugs compared composition 5:Stir-baked SEMEN RAPHANI 12.2g, it dried orange peel 19.45g, hawthorn 19.45g, Chinese yam 19.45g, fries Cassia seed 19.45g adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration phase When in crude drug be 0.45g mL-1
(7)Drugs compared composition 6:It is stir-baked SEMEN RAPHANI 12.2g, dried orange peel 19.45g, hawthorn 19.45g, Chinese yam 19.45g, big Jujube 19.45g adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration is equivalent to Crude drug is 0.45g mL-1
(8)Drugs compared composition 7:Houpo Paiqi Mixture(RuiYang Pharmacy Co., Ltd, Chinese medicines quasi-word Z 20050563), it is 0.45g mL that concentration, which is made, and is equivalent to crude drug-1
(9)Control group 8:Take same amount of distilled water as a contrast.
1.4 experimental method
To the influence in body mouse gastric emptying, Intestinal pushing
(1) determination of dosage
Every mouse large dosage group test liquid solution 0.03mL is calculated by body surface area, it is contemplated that the damage in extraction separation process It loses.Give 18 respectively through trial test(2/every group)4 times of mouse large dosage, 6 times, 8 times, 10 times, each mouse is without exception Reaction, it is final to determine that dosage is 0.3ml.
(2) method
108 kunming mices, half male and half female are randomly divided into beverage group of the present invention, drugs compared group 1-7, control group 8, amount to 9 Group, every group 12.Before mouse experiment fasting for 24 hours, free water during fasting.Using administration by gavage, test group of animals gavages respectively A concentration of 0.45gmL-1Beverage 0.3ml of the present invention, drugs compared group 7 gavage a concentration of 0.45gmL-1Cortex Magnoliae Officinalis is vented liquid 0.3ml, control group gavage distilled water 0.3ml.Lh after administration gives semisolid nutrition and pastes, cervical dislocation after every 0.4mL, 20min It puts to death.Stomach cardia and pylorus are ligatured, takes stomach to weigh to obtain stomach gross weight, then body of stomach is cut off along greater curvature, after washing away gastric content It wipes and dry weighs to obtain stomach net weight.Using stomach gross weight and the difference of stomach net weight as residue weight in stomach, in stomach, residue, which accounts for, fills half admittedly The weight percent of body paste is residual rate in stomach.It is rapid simultaneously to take out small intestine, it is directly laid on blank sheet of paper after gently removing, measures pylorus The distance in forward position is pasted to ileocecum portion overall length and pylorus to black semisolid.The distance in forward position is pasted with pylorus to black semisolid (Promote length)Pylorus is accounted for ileocecus overall length(Small intestine overall length)Percentage be Intestinal propulsive rate.
Residual rate in stomach=(Stomach gross weight-stomach net weight)/ filled nutrition paste weight × 100%
Intestinal propulsive rate=propulsion length/small intestine overall length × 100%
(3)Experimental result
Analysis of experimental results software:SPSS 13.0
1 beverage of the present invention of table to mouse gastric emptying influence (±s , n =12)
Note: a:Compared with the control group, P<0.01, significant difference;b:Compared with drugs compared group 7, P<0.05, significant difference; c:Compared with beverage group of the present invention, P<0.05, significant difference.
2 beverage of the present invention of table to mouse Intestinal pushing influence (±s , n =12)
Note:a:Compared with the control group, P<0.01, significant difference;b:Compared with drugs compared group 7, P<0.05, significant difference; c: Compared with beverage group of the present invention, P<0.05, significant difference.
The experimental results showed that:Residual rate, Intestinal pushing Lv and control group, drugs compared group have significantly in beverage group stomach of the present invention Sex differernce has apparent progradation, and mouse Intestinal pushing power can be remarkably reinforced.
1.5 conclusion
Beverage group of the present invention can significantly promote mouse gastric emptying and can enhance small intestine push power.And present invention operation heel row Gas beverage flavour of a drug form and dosage perfection collocation, have obvious synergistic function together, the missing of any medicine simply is all The whole curative effect that pharmaceutical composition can be substantially reduced has good result to postoperative bowel patient.
Specific implementation mode
1, a kind of beverage for final vacuum of performing the operation, it is made of the bulk pharmaceutical chemicals of following parts by weight:Stir-baked SEMEN RAPHANI 5g, Dried orange peel 17g, hawthorn 17g, Chinese yam 17g, jujube 17g, the sub- 17g of fried cassia, preparation method are to take bulk pharmaceutical chemicals, and 18 times of amount water is added to carry It takes twice, mixed extract, concentrates, add honey 14ml, be settled to 200ml, it is 0.45gmL that concentration, which is equivalent to crude drug,-1
2, a kind of beverage for final vacuum of performing the operation, it is made of the bulk pharmaceutical chemicals of following parts by weight:Stir-baked SEMEN RAPHANI 10g, dried orange peel 16g, hawthorn 16g, Chinese yam 16g, jujube 16g, the sub- 16g of fried cassia, preparation method are to take bulk pharmaceutical chemicals, add 18 times of amounts Water extracts twice, mixed extract, and concentration adds honey 14ml, is settled to 200ml, it is 0.45g that concentration, which is equivalent to crude drug, mL-1
3, a kind of beverage for final vacuum of performing the operation, it is made of the bulk pharmaceutical chemicals of following parts by weight:Stir-baked SEMEN RAPHANI 15g, dried orange peel 15g, hawthorn 15g, Chinese yam 15g, jujube 15g, the sub- 15g of fried cassia, preparation method are to take bulk pharmaceutical chemicals, add 18 times of amounts Water extracts twice, mixed extract, and concentration adds honey 14ml, is settled to 200ml, it is 0.45g that concentration, which is equivalent to crude drug, mL-1。。

Claims (3)

1. a kind of beverage for final vacuum of performing the operation, it is characterised in that:It is made of the bulk pharmaceutical chemicals of following parts by weight:Fry Lay Fu 5-15g, dried orange peel 10-20g, hawthorn 10-20g, Chinese yam 10-20g, jujube 10-20g, the sub- 10-20g of fried cassia.
2. according to the beverage for final vacuum of performing the operation described in claim 1, it is characterised in that:It is by following parts by weight Bulk pharmaceutical chemicals composition:Stir-baked SEMEN RAPHANI 10g, dried orange peel 16g, hawthorn 16g, Chinese yam 16g, jujube 16g, the sub- 16g of fried cassia.
3. the preparation method of the beverage according to claim 1 or 2 for final vacuum of performing the operation, it is characterised in that:Take raw material Medicine adds 18 times of amount water extractions twice, and mixed extract, concentration adds honey 14ml, is settled to 200ml, concentration is equivalent to crude drug For 0.45gmL-1
CN201810261135.1A 2018-03-28 2018-03-28 Beverage for postoperative gas exhaust Active CN108478683B (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
CN201810261135.1A CN108478683B (en) 2018-03-28 2018-03-28 Beverage for postoperative gas exhaust

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138990A (en) * 1995-06-27 1997-01-01 郑铁保健食品厂 Oral liquid for preventing and curing infantile anorexia and its prepn
CN1754453A (en) * 2004-09-30 2006-04-05 刘滨德 Health food with function of promoting and eliminating indigestion, mositurizing bowel and defaecation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138990A (en) * 1995-06-27 1997-01-01 郑铁保健食品厂 Oral liquid for preventing and curing infantile anorexia and its prepn
CN1754453A (en) * 2004-09-30 2006-04-05 刘滨德 Health food with function of promoting and eliminating indigestion, mositurizing bowel and defaecation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
冉小库等: "茯苓对正常小鼠胃肠功能的影响", 《中国现代中药》 *

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