CN105233233A - Traditional Chinese medicine compound treating chronic gastric ulcers and preparation method thereof - Google Patents
Traditional Chinese medicine compound treating chronic gastric ulcers and preparation method thereof Download PDFInfo
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- CN105233233A CN105233233A CN201510798350.1A CN201510798350A CN105233233A CN 105233233 A CN105233233 A CN 105233233A CN 201510798350 A CN201510798350 A CN 201510798350A CN 105233233 A CN105233233 A CN 105233233A
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Abstract
The invention discloses a traditional Chinese medicine compound treating chronic gastric ulcers and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine compound treating the chronic gastric ulcers is prepared from the following raw materials and pharmaceutically acceptable carriers. The raw material include, by weight, 15-25 parts of poria cocos, 15-25 parts of pinellia ternate, 15-25 parts of cassia twigs, 10-20 parts of lindera aggregate, 10-20 parts of peony, 10-20 parts of hawthorn fruits, 10-20 parts of peach kernels, 10-20 parts of red dates, 10-15 parts of endothelium corneum gigeriae galli, 10-15 parts of coptidis rhizome, 10-15 parts of dried ginger and 10-15 parts of liquorice. The invention further discloses the preparation method of the compound. According to the pattern of traditional Chinese medicine diagnosis and treatment based on overall analysis and assistant and guide, the traditional Chinese medicines are subjected to scientific compatibility, effective medicine combinations are provided, the medicines are collaboratively and mutually balanced, and the gastric ulcers, gasteremphraxis, emesis and the like which are caused by the gastric ulcers can be well treated.
Description
Technical field
The present invention relates to technical field of Chinese medicines, is a kind of Chinese medicine composition for the treatment of chronic gastric ulcer and preparation method thereof specifically.
Background technology
Gastric ulcer refers to that the chronic ulcer between cardia to pylorus is referred to as, it is the one of peptic ulcer, peptic ulcer can occur in Stomach duodenum, also can occur in lower esophageal, near harmonization of the stomach intestinal anastomosis mouth and in your diverticulum of Meike on Ectopic Gastric Mucosa.The formation of these ulcer is all relevant with pepsic Digestion with gastric acid, therefore is called peptic ulcer.
Chronic gastric ulcer with the rhythmicity upper abdominal pain of recurrent exerbation for clinical characters, often with heating installation, return acid, the sensation such as scorching hot, noisy, even also have Nausea and vomiting, hematemesis, have blood in stool.Circle, oval chronic ulcer is had in gastrointestinal local.The cause of disease of chronic ulcer disease is very complicated, not yet clear, it is generally acknowledged relevant with the Digestion of gastric juice.Study for many years and prove, the formation of ulcer is coat of the stomach or duodenal wall tissue by the result of gastric acid and pepsin digestion, and this self-digestion process is the immediate cause of ulcer.
Doctor trained in Western medicine prevent and treat chronic gastritis means, mainly concentrate on antacid, repair digestive tract power, to kill in helicobacter pylori in a certain respect.Some medicine, as aspirin, dexamethasone, prednisone, indometacin etc., has stimulation to gastric mucosa, can increase the weight of the state of an illness of gastric ulcer, so therapeutic effect is not remarkable.Chinese Traditional Medicines have sunflower WEIKANGLING, KUIYANGLING JIAONANG etc., have good curative effect as ancillary drug to gastric ulcer.
So the good relief of symptoms of a kind of energy of exploitation, cure rate are high, and the medicine that side effect is little, has actual application value and major and immediate significance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of chronic gastric ulcer and preparation method thereof.
For solving the problems of the technologies described above, technical scheme of the present invention is: be made up of the raw material of following weight portion and pharmaceutically acceptable carrier: Poria 15-25 part, Rhizoma Pinelliae 15-25 part, Ramulus Cinnamomi 15-25 part, Radix Linderae 10-20 part, Radix Paeoniae 10-20 part, Fructus Crataegi 10-20 part, Semen Persicae 10-20 part, Fructus Jujubae 10-20 part, Endothelium Corneum Gigeriae Galli 10-15 part, Rhizoma Coptidis 10-15 part, Rhizoma Zingiberis 10-15 part, Radix Glycyrrhizae 10-15 part.
As preferred technical scheme, described a kind of Chinese medicine composition for the treatment of chronic gastric ulcer, is made up of the raw material of following weight portion and pharmaceutically acceptable carrier: 20 parts, Poria, the Rhizoma Pinelliae 20 parts, Ramulus Cinnamomi 20 parts, the Radix Linderae 15 parts, Radix Paeoniae 15 parts, Fructus Crataegi 15 parts, 15 parts, Semen Persicae, Fructus Jujubae 15 parts, Endothelium Corneum Gigeriae Galli 12 parts, Rhizoma Coptidis 12 parts, Rhizoma Zingiberis 12 parts, 12 parts, Radix Glycyrrhizae.
As preferred technical scheme, described a kind of Chinese medicine composition for the treatment of chronic gastric ulcer is tablet, capsule, granule, oral liquid, syrup, injection, pill.
Present invention also offers above-mentioned preparation method, comprise the following steps:
(1) get the raw materials ready
Take Poria, the Rhizoma Pinelliae, Ramulus Cinnamomi, the Radix Linderae, Radix Paeoniae, Fructus Crataegi, Semen Persicae, Fructus Jujubae, Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis, Rhizoma Zingiberis, Radix Glycyrrhizae by weight, for subsequent use;
(2) soak, decoct
The medical material cold water got ready in step (1) is soaked 20 ~ 30 minutes, decocts with water 2-4 time, each 2-3 hour, collecting decoction;
(3) filter, concentrate
The decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, then filtrate is concentrated into the clear paste of relative density 1.10-1.25 at 25-35 DEG C, be cooled to room temperature;
(4) ethanol extraction
Add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol;
(5) medicament is made
To reclaim the filtrate cold drying after ethanol, pulverize, add pharmaceutically acceptable carrier, mixing, makes medicament.
Treat in the Chinese medicine composition of chronic gastric ulcer the present invention is a kind of, pharmaceutically acceptable carrier is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
The invention still further relates to a kind of purposes of Chinese medicine composition in the medicine of preparation treatment gastropathy for the treatment of chronic gastric ulcer.
The property of medicine of crude drug that the present invention adopts, pharmacology and effect are as follows:
Poria: sweet in the mouth, light, property are put down, can eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
The Rhizoma Pinelliae: pungent loose warm-dryness syndrome is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel.Energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.Control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea lump in the abdomen.
The Radix Linderae: acrid in the mouth, warm in nature.Return spleen, stomach, liver, kidney, urinary bladder channel.Promoting the circulation of QI to relieve pain; Warming kidney for dispelling cold.
Radix Paeoniae: bitter in the mouth, acid, gas is put down, be slightly cold, and can rise and can fall, the yang aspect of yin, slightly poisonous.Enter brothers lunar, the warp of the moon that enters to faint again, few sun.Can rush down and can fall apart, can complementary energy receive, Chi Baixiang, without dividing each other.Its merit is entirely at suppressing the hyperactive liver, and liver puts down the taste that are then unable to, and internal organs are respectively pacified, defecation diarrhea, and burning hot from loose, strongly fragrant gas removes certainly, and carbuncle disappears certainly, and hard long-pending from change, dysentery goes certainly, and dysentery pain is from peace.
Fructus Crataegi: help digestion long-pending, dissipating blood stasis blood, expelling tenia.
Semen Persicae: bitter but sweet flavor and property are put down, and can be absorbed, effectively treat congestion, loosening bowel to relieve constipation by the heart, liver, large intestine.
Fructus Jujubae: weakness of the spleen and stomach, diarrhoea, the people of lassitude, Fructus Jujubae and Rhizoma Zingiberis, the same use of the Rhizoma Pinelliae, can the accidentally caused gastritis of Therapeutic diet as the symptom such as flatulence, vomiting.
Endothelium Corneum Gigeriae Galli: property is sweet puts down, be slightly cold, nontoxic, returns spleen, stomach, kidney, urinary bladder channel.Can promoting digestion and invigorating the stomach, arresting seminal emission.Cure mainly removing food stagnancy stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Rhizoma Coptidis: the disease patient such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.There is antibacterial, that antiviral, antiinflammatory are antipyretic effect.
Rhizoma Zingiberis: pungent, hot, returns spleen, kidney, the heart, lung meridian, and energy warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention, for syndrome of deficient cold of spleen and stomach.
Radix Glycyrrhizae: nature and flavor are sweet flat, GUIXIN, lung, spleen, stomach warp.The merit of tool invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine.
According to the general layout of the traditional Chinese medical science, Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, monarch, scientific compatibility is carried out to above-mentioned Chinese medicine and proposes effective drug regimen, as the main Chinese medicinal materials that the Poria of monarch drug of the present invention, the Rhizoma Pinelliae, Ramulus Cinnamomi are treatment chronic gastric ulcers, there is leading therapeutical effect, but there is certain injury for healthy cell, as adjuvant drug of the present invention, make medicine can balance the toxic and side effects of monarch drug, ministerial drug, in addition, the synergism of Fructus Jujubae, Rhizoma Zingiberis and the Rhizoma Pinelliae, well can treat the symptom such as flatulence, vomiting that Stomach in Patients ulcer causes.In addition, the present invention can be good at regulating gastric acid and pepsic secretion, has good bactericidal effect to helicobacter pylori.
Medicine effect is tested
Test the impact of 1 the present invention on rat gastric acid, pepsinia
Get cleaning grade rat 50, body weight 180-220g, male and female half and half, be divided into 5 groups at random, often organize 10.If blank group, positive controls (Aomei Bearing score capsule), the basic, normal, high dosage group of the present invention, wherein basic, normal, high three dosage of the present invention be respectively 0.455,0.91,1.82g crude drug/kg, the CMC of above medicine all with 0.5% makes the medicinal liquid of equivalent, give each group of gastric infusion respectively according to 1ml/100g, wherein blank group gives the sodium chloride solution of equivalent.Continuous gavage one week, every day 1 time, can't help water 24 hours in fasting after one week.Then by rat anesthesia, along the otch cutting off 2-3 centimetre under xiphoid-process, injection of medicine, ligation, fasting prohibits water by sacrifice after 6 hours, and take out Mus stomach, collection endpage 10ml, gets supernatant standard gastric juice, and carry out gastric analysis.
With method and the MettShi capillary tube method of acid-base indicator, the test data drawn as calculated is in table 1 and table 2.
Table 1 the present invention is on the impact of gastric acid secretion
Table 2 the present invention is on the impact of pepsinia
Table 1 with in table 2 each group all there is statistical significance compared with the data of blank group, P value is all less than 0.05.Therefore can reach a conclusion: the present invention has obvious regulating action to gastric acid and pepsic secretion.
Clinical observation
Inventor once repeatedly changed prescription of the present invention, was finally defined as compatible combination disclosed by the invention, and the nearly 400 many cases patients of sequential treatment, through follow-up investigation statistics for many years, cure rate is up to more than 95%.Due to patient itself, some patient does not adhere to successional taking medicine, and has not yet fully recovered so far, but Be very effective.By observation in recent years, almost there is no toxic and side effects, patient do not occur ulcer increase the weight of or other etc. symptom.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.
embodiment 1
Take Poria 150g, Rhizoma Pinelliae 150g, Ramulus Cinnamomi 150g, Radix Linderae 100g, Radix Paeoniae 100g, Fructus Crataegi 100g, Semen Persicae 100g, Fructus Jujubae 100g, Endothelium Corneum Gigeriae Galli 100g, Rhizoma Coptidis 100g, Rhizoma Zingiberis 100g, Radix Glycyrrhizae 100g, add cold water leaching 20 ~ 30 minutes, then decoct 2-4 time, each 2-3 hour, collecting decoction, the decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, again filtrate is concentrated into the clear paste of relative density 1.12-1.20 at 30-70 DEG C, be cooled to room temperature, add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol; To reclaim the filtrate cold drying after ethanol, pulverize, add binding agent, surfactant and correctives, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is granular form.
embodiment 2
Take Poria 175g, Rhizoma Pinelliae 175g, Ramulus Cinnamomi 175g, Radix Linderae 125g, Radix Paeoniae 125g, Fructus Crataegi 125g, Semen Persicae 125g, Fructus Jujubae 125g, Endothelium Corneum Gigeriae Galli 110g, Rhizoma Coptidis 110g, Rhizoma Zingiberis 110g, Radix Glycyrrhizae 110g, add cold water leaching 20 ~ 30 minutes, then decoct 2-4 time, each 2-3 hour, collecting decoction, the decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, again filtrate is concentrated into the clear paste of relative density 1.12-1.20 at 30-70 DEG C, be cooled to room temperature, add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol; To reclaim the filtrate cold drying after ethanol, pulverize, add binding agent, surfactant and correctives, granulate after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is Capsule form.
embodiment 3
Take Poria 200g, Rhizoma Pinelliae 200g, Ramulus Cinnamomi 200g, Radix Linderae 150g, Radix Paeoniae 150g, Fructus Crataegi 150g, Semen Persicae 150g, Fructus Jujubae 150g, Endothelium Corneum Gigeriae Galli 120g, Rhizoma Coptidis 120g, Rhizoma Zingiberis 120g, Radix Glycyrrhizae 120g, add cold water leaching 20 ~ 30 minutes, then decoct 2-4 time, each 2-3 hour, collecting decoction, the decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, again filtrate is concentrated into the clear paste of relative density 1.12-1.20 at 30-70 DEG C, be cooled to room temperature, add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol; To reclaim the filtrate cold drying after ethanol, pulverize, add binding agent, surfactant and correctives, film-making after mix homogeneously, cold drying, tabletting, packaging, obtain compositions of the present invention, it is tablet form.
embodiment 4
Take Poria 225g, Rhizoma Pinelliae 225g, Ramulus Cinnamomi 225g, Radix Linderae 175g, Radix Paeoniae 175g, Fructus Crataegi 175g, Semen Persicae 175g, Fructus Jujubae 175g, Endothelium Corneum Gigeriae Galli 135g, Rhizoma Coptidis 135g, Rhizoma Zingiberis 135g, Radix Glycyrrhizae 135g, add cold water leaching 20 ~ 30 minutes, then decoct 2-4 time, each 2-3 hour, collecting decoction, the decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, again filtrate is concentrated into the clear paste of relative density 1.12-1.20 at 30-70 DEG C, be cooled to room temperature, add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol; To reclaim the filtrate cold drying after ethanol, pulverize, add binding agent, surfactant and correctives, make oral agents after mix homogeneously, packaging, obtains compositions of the present invention.
embodiment 5
Take Poria 250g, Rhizoma Pinelliae 250g, Ramulus Cinnamomi 250g, Radix Linderae 200g, Radix Paeoniae 200g, Fructus Crataegi 200g, Semen Persicae 200g, Fructus Jujubae 200g, Endothelium Corneum Gigeriae Galli 150g, Rhizoma Coptidis 150g, Rhizoma Zingiberis 150g, Radix Glycyrrhizae 150g, add cold water leaching 20 ~ 30 minutes, then decoct 2-4 time, each 2-3 hour, collecting decoction, the decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, again filtrate is concentrated into the clear paste of relative density 1.12-1.20 at 30-70 DEG C, be cooled to room temperature, add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol; To reclaim the filtrate cold drying after ethanol, pulverize, add binding agent, surfactant and correctives, pill after mix homogeneously, cold drying, granulate, packaging, obtain compositions of the present invention, it is pill.
The equipment used in preparation method of the present invention is the common equipment in pharmaceutical industries field, does not repeat them here.
The foregoing is only the schematic detailed description of the invention of the present invention, and be not used to limit scope of the present invention.Any those skilled in the art, equivalent variations done under the prerequisite not departing from design of the present invention and principle and amendment, all should belong to the scope of protection of the invention.
Claims (6)
1. treat the Chinese medicine composition of chronic gastric ulcer for one kind, it is characterized in that, be made up of the raw material of following weight portion and pharmaceutically acceptable carrier: Poria 15-25 part, Rhizoma Pinelliae 15-25 part, Ramulus Cinnamomi 15-25 part, Radix Linderae 10-20 part, Radix Paeoniae 10-20 part, Fructus Crataegi 10-20 part, Semen Persicae 10-20 part, Fructus Jujubae 10-20 part, Endothelium Corneum Gigeriae Galli 10-15 part, Rhizoma Coptidis 10-15 part, Rhizoma Zingiberis 10-15 part, Radix Glycyrrhizae 10-15 part.
2. a kind of Chinese medicine composition for the treatment of chronic gastric ulcer as requested described in 1, it is characterized in that, be made up of the raw material of following weight portion and pharmaceutically acceptable carrier: 20 parts, Poria, the Rhizoma Pinelliae 20 parts, Ramulus Cinnamomi 20 parts, the Radix Linderae 15 parts, Radix Paeoniae 15 parts, Fructus Crataegi 15 parts, 15 parts, Semen Persicae, Fructus Jujubae 15 parts, Endothelium Corneum Gigeriae Galli 12 parts, Rhizoma Coptidis 12 parts, Rhizoma Zingiberis 12 parts, 12 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of chronic gastric ulcer according to claim 1 and 2, is characterized in that: described compositions is tablet, capsule, granule, oral liquid, syrup, injection, pill.
4. a kind of Chinese medicine composition for the treatment of chronic gastric ulcer according to claim 1 and 2, it is characterized in that, its preparation method comprises the following steps:
(1) get the raw materials ready
Take Poria, the Rhizoma Pinelliae, Ramulus Cinnamomi, the Radix Linderae, Radix Paeoniae, Fructus Crataegi, Semen Persicae, Fructus Jujubae, Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis, Rhizoma Zingiberis, Radix Glycyrrhizae by weight, for subsequent use;
(2) soak, decoct
The medical material cold water got ready in step (1) is soaked 20 ~ 30 minutes, decocts with water 2-4 time, each 2-3 hour, collecting decoction;
(3) filter, concentrate
The decocting liquid merged is filtered out filtrate with 400 ~ 600 object screen cloths, then filtrate is concentrated into the clear paste of relative density 1.10-1.25 at 25-35 DEG C, be cooled to room temperature;
(4) ethanol extraction
Add alcohol reflux 3-6 time of 2-4 times amount 80%, filter, from filtrate, reclaim ethanol;
(5) medicament is made
To reclaim the filtrate cold drying after ethanol, pulverize, add pharmaceutically acceptable carrier, mixing, makes medicament.
5. a kind of Chinese medicine composition for the treatment of chronic gastric ulcer according to claim 1-2, is characterized in that: described pharmaceutically acceptable carrier is selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
6. a kind of purposes of Chinese medicine composition in the medicine of preparation treatment gastropathy for the treatment of chronic gastric ulcer according to claim 1-2.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107468857A (en) * | 2017-08-29 | 2017-12-15 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicinal preparation method that can treat gastric ulcer |
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| WO2007113855A1 (en) * | 2006-03-30 | 2007-10-11 | Council Of Scientific & Industrial Research | A bioactive fraction from zingiber officinale and a process for the preparation thereof |
| CN102847113A (en) * | 2012-08-30 | 2013-01-02 | 李承平 | Ginseng and coptis chinensis capsules with function of stasis removing |
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| CN1039968A (en) * | 1989-06-14 | 1990-02-28 | 陈江辉 | The compound method of gastritis curing oral liquid |
| WO2007113855A1 (en) * | 2006-03-30 | 2007-10-11 | Council Of Scientific & Industrial Research | A bioactive fraction from zingiber officinale and a process for the preparation thereof |
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| CN107468857A (en) * | 2017-08-29 | 2017-12-15 | 成都泠汐尚品科技有限公司 | A kind of Chinese medicinal preparation method that can treat gastric ulcer |
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Application publication date: 20160113 |