CN104083429A - Radix astragali and acanthopanax gracilistylus soluble powder for poultry and preparation method thereof - Google Patents
Radix astragali and acanthopanax gracilistylus soluble powder for poultry and preparation method thereof Download PDFInfo
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Abstract
The invention discloses radix astragali and acanthopanax gracilistylus soluble powder for poultry and a preparation method thereof. The soluble powder prepared by adding glucose as an auxiliary material on the basis of a formula which comprises radix astragali and acanthopanax senticosus and changing a dosage form and a process can be used for effectively treating the diseases, namely chicken immunodeficiency, anti-stress and the like. According to the radix astragali and acanthopanax gracilistylus soluble powder, the dosage form is changed on the basis of a human medicine radix astragali and acanthopanax gracilistylus tablet, so that the medicine can be used for poultry animals; an extraction preparation process is also changed, so that the yield of syringin extracted from the acanthopanax senticosus is higher; glucose is added as the auxiliary material, so that the prepared soluble powder has good formability, hygroscopicity, solubility and mouthfeel.
Description
Technical field
The present invention relates to a kind of poultry astragalus root-acanthopanax soluble powder and preparation method thereof, belong to field of veterinary.
Background technology
" the astragalus root-acanthopanax sheet " that " Chinese medicine ministry standard " is the 6th 42 pages, weak for body void clinically at people's medicine, soreness of the waist and knees, loses eye dreaminess, inappetence etc.
At present the disease such as the low and anti-stress of poultry immunity is all mainly western medicine, and medicine side effect is large, and curative effect is also unstable.
Summary of the invention
The object of the present invention is to provide a kind of poultry astragalus root-acanthopanax soluble powder and preparation method thereof, on the basis of the formula Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi, add glucose as adjuvant, and change dosage form and technique, and make soluble powder, can effectively treat the diseases such as the low and anti-stress of chicken immune.
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, glucose 6-8 part; Preparation method is: the Radix Astragali decocts with water 2 times, each 2.5-3.5 hour, the quality of the 1st water is 7.5-8.5 times of Radix Astragali quality, the quality of the 2nd water is 5.5-6.5 times of Radix Astragali quality, merge 2 times decocting liquid, filter, filtrate decompression is condensed into the extractum of relative density 1.18-1.22 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water each 3 hours 2 times after pulverizing, the quality of the 1st water is 9.5-10.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 7.5-8.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filter, filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.18-1.22; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
The Radix Astragali is leguminous plant Radix Astragali Astragalus membranaceus(Fisch.) dry root (" Chinese veterinary pharmacopoeia " two) of Bge.; Radix Et Caulis Acanthopanacis Senticosi, the decoction pieces (" Chinese veterinary pharmacopoeia " two) of making for the dry root and rhizome of Araliaceae Radix Et Caulis Acanthopanacis Senticosi Acanthopanax senticosus (Rupr. et Maxim.) Harms.
The present invention's prescription comes from " Chinese medicine ministry standard " the 6th 42 pages " astragalus root-acanthopanax sheet ", weak for body void clinically at people's medicine, and soreness of the waist and knees loses eye dreaminess, inappetence etc.The present invention is according to its prescription function of taste of Chinese medicine and modern pharmacology research, is applied to the treatment of the diseases such as the low and anti-stress of poultry immunity.
Dosage form of the present invention is soluble powder, it is compared with oral liquid, granule, there is following advantage: (1) is compared with oral liquid, soluble powder both can mix drink administration, also can mixed feeding administration, under the different state of an illness, user can select to be more suitable for the administering mode of drug utilization and disease treatment, when as higher in summer temp, can avoid the generation of situations such as fermenting, rotten; (2) compared with granule, soluble powder processing technology is simple, and medicament contg is high, and production and transport cost is low, is conducive to save social resources.
The present invention selects glucose as adjuvant, make comparisons with conventional adjuvant sucrose, lactose, soluble starch, taking mouldability, appearance character, dissolubility and the mouthfeel of soluble powder as investigating index, get 4 parts of the mixing extract powders of the Radix Astragali and Radix Et Caulis Acanthopanacis Senticosi in preparation prescription ratio, mix with glucose, sucrose, lactose, soluble starch respectively, result of the test is as shown in table 1 below:
Result of the test shows:
1. taking glucose as adjuvant, the formability of soluble powder, hygroscopicity, dissolubility, good mouthfeel, and the price of glucose is relatively reasonable, and cost is not high, pretends recommendation;
2. taking sucrose as adjuvant, the formability of soluble powder, dissolubility, good mouthfeel, but sucrose is pulverized rear easy caking in process of production, causes the caking of soluble powder, therefore do not recommend;
3. taking lactose as adjuvant, the formability of soluble powder, hygroscopicity, dissolubility, good mouthfeel, but lactose price is relatively expensive, considers production cost, therefore do not recommend;
4. taking soluble starch as adjuvant, formability, the hygroscopicity of soluble powder are good, but dissolubility, mouthfeel are poor, therefore do not recommend.
The present invention selects the extracting method of Radix Et Caulis Acanthopanacis Senticosi, and taking syringoside yield as index, single factor is investigated amount of water to decocting the impact of effect: get each 5 parts of Radix Et Caulis Acanthopanacis Senticosi coarse powder 80g, decoct with water 2 times, each 3 hours, add water and doubly measure by table 2 setting level.Collecting decoction, filters, and filtrate concentrates and be settled to 100ml, for subsequent use.
Precision measures above-mentioned storing solution 10ml, evaporate to dryness, divides (10ml, 5ml three times with methanol 20ml, 5ml) solution transfer is to 25ml measuring bottle, add dissolve with methanol and be diluted to scale, shake up, filter, get subsequent filtrate, as test sample, measure according to the content assaying method under Radix Et Caulis Acanthopanacis Senticosi extractum (" Chinese Pharmacopoeia ") item, calculate the content of syringoside in storing solution.
In table 2, visible amount of water has impact to the content of syringoside in extracting solution, adds water that it is high doubly to measure, and the rate of transform is high.When the amount of adding water is doubly during to 10,8 times of amounts, then increase the water yield content is not had to positive contribution, therefore the doubly amount that adds water is chosen as 10 times of amounts left and right for the first time, for the second time about 8 times of amounts.
Therefore, the invention has the advantages that: on the basis of people's medicine " astragalus root-acanthopanax sheet ", change dosage form, make the medicine can be for poultry animal; Also changed extraction and preparation technique, make Radix Et Caulis Acanthopanacis Senticosi extract syringoside yield out higher simultaneously; And add glucose as adjuvant, the formability of the soluble powder of preparation, hygroscopicity, dissolubility, good mouthfeel.
detailed description of the invention:
Embodiment 1:
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of glucoses; Preparation method is: the Radix Astragali decocts with water 2 times, and each 2.5 hours, the quality of the 1st water was 7.5 times of Radix Astragali quality, the quality of the 2nd water is 5.5 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.18 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water each 3 hours 2 times after pulverizing, the quality of the 1st water is 9.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 7.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filter, filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.18; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
Embodiment 2:
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 7 parts of glucoses; Preparation method is: the Radix Astragali decocts with water 2 times, and each 3 hours, the quality of the 1st water was 8 times of Radix Astragali quality, the quality of the 2nd water is 6 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.20 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water 2 times after pulverizing, and each 3 hours, the quality of the 1st water was 10 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 8 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filters, and filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.20; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
Embodiment 3:
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 8 parts of glucoses; Preparation method is: the Radix Astragali decocts with water 2 times, and each 3.5 hours, the quality of the 1st water was 8.5 times of Radix Astragali quality, the quality of the 2nd water is 6.5 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.22 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water each 3 hours 2 times after pulverizing, the quality of the 1st water is 10.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 8.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filter, filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.22; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
Embodiment 4:
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of glucoses; Preparation method is: the Radix Astragali decocts with water 2 times, and each 2 hours, the quality of the 1st water was 7 times of Radix Astragali quality, the quality of the 2nd water is 5 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.17 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water 2 times after pulverizing, and each 3 hours, the quality of the 1st water was 9 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 7 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filters, and filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.17; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
Embodiment 5:
A kind of poultry astragalus root-acanthopanax soluble powder, is made up of the raw material of following mass fraction: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of glucoses; Preparation method is: the Radix Astragali decocts with water 2 times, and each 4 hours, the quality of the 1st water was 9 times of Radix Astragali quality, the quality of the 2nd water is 7 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.23 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water 2 times after pulverizing, and each 3 hours, the quality of the 1st water was 11 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 9 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filters, and filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.23; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
Pharmacodynamics test
1, astragalus root-acanthopanax soluble powder on functional dyspepsia rat stomach intestinal motive force impact
1.1 material
1.1.1 animal rat, body weight: 180～220g, is provided by University Of Nanchang's medical college Experimental Animal Center.
1.1.2 equipment balance, ruler, operating scissors, surgical forceps, stitching thread.
1.1.3 medicine and reagent astragalus root-acanthopanax soluble powder (100g/ bag, 1.6g crude drug/g), lot number: 20080115, Jiangxi Zhongcheng TCM Extract Co., Ltd. produces.Astragalus root-acanthopanax sheet (48/box), lot number: 20071202, Hei Long group ancient cooking vessel Hengsheng, Qiqihar pharmaceutcal corporation, Ltd.
1.2 method
1.2.1 10g sodium carboxymethyl cellulose (CMC) is got in the preparation that semi-solid nutrition is stuck with paste, and is dissolved in 250ml distilled water, adds respectively 16g milk powder, 8g sugar, 8g starch and 2g active carbon end, stirs.Be mixed with the black semisolid pastel of the about 300g of 300ml.Refrigerator cold-storage, the used time returns to room temperature.
1.2.2 body weight 180～220g healthy rat is got in grouping, and single cage fasting 24 hours, freely drinks water, and is divided at random 8 groups, and 10 every group, blank group, model group, positive drug matched group, astragalus root-acanthopanax soluble powder embodiment 1-5 group.
1.2.3 modeling method is made functional dyspepsia (FD) model with reference to Guo Shi appropriateness folder tail legal system: press from both sides tail, each 30min, every day 4 times, continued stimulus 1 week with test tube clamp.
1.2.4 medication positive drug matched group gavage gives astragalus root-acanthopanax sheet medicine 2.88g crude drug/kg, astragalus root-acanthopanax soluble powder embodiment 1-5 organizes gavage respectively and gives 2.88g crude drug/kg, volume is 1ml/100g, and blank group gives respective volume normal saline; Every day 1 time, finish latter 1 day successive administration 5 days from modeling, normal feed and drinking-water during administration.
1.2.4 after the administration of gastric emptying speed last 1 hour, give semi-solid black by fasting (the can't help water) rat oral gavage of 18 hours and stick with paste, every 1ml.After 30 minutes, put to death rat, open abdomen, ligation stomach cardia and pylorus, get stomach, wipes after dry and claim full weight with filter paper, then cuts off body of stomach along greater gastric curvature, washes away to wipe after gastric content dryly, claims net weight.Taking the difference of stomach full weight stomach function regulating net weight as gastric residue weight, calculate gastric residue account for fills with semi-solid paste weight percentage ratio be gastric residual rate.Take out small intestinal simultaneously rapidly, small intestinal is pulled into straight line after peeling off gently mesentery, measure pylorus and stick with paste to black semisolid to the small intestinal total length of ileocecus and pylorus the distance in forward position.Stick with paste the distance in forward position to account for pylorus to the percentage rate of ileocecus total length be intestinal propulsion rate taking pylorus to black semisolid.
1.3 result
The gastric residual rate of model group rat increases (P<0.01), and intestinal propulsion rate reduces (P<0.05), and showing to press from both sides tail method can stimulation in rats cause functional dyspepsia.Astragalus root-acanthopanax soluble powder embodiment 1-5 group and positive drug group can reduce the gastric residual rate of rat model, improve intestinal propulsion rate, but best with the embodiment 1-3 group effect in processing range, compared with model group, there were significant differences (table 3).
With the comparison of blank group,
Δ Δp<0.01,
Δp<0.05; With the comparison of model group group, * * P<0.01, * P<0.05
1.4 brief summary
Gastric emptying, the intestinal propulsion of astragalus root-acanthopanax soluble powder to dyspepsia rat model has facilitation.
2, the impact of engulfing clean up ability of astragalus root-acanthopanax soluble powder on mice-mononuclear phagocyte system inertia carbon granule
2.1 material
2.1.1 animal mice, Kunming kind, body weight: 18～22g, is provided by University Of Nanchang's medical college Experimental Animal Center.
2.1.2 equipment 0.25ml syringe, No. 4 syringe needles; Suction pipe; 721 spectrophotometers.
2.1.3 medicine and reagent india ink, 1% gelatin solution, 0.1%Na
2cO
3.Astragalus root-acanthopanax soluble powder (100g/ bag, 1.6g crude drug/g), and lot number: 20080115, Jiangxi Zhongcheng TCM Extract Co., Ltd. produces.Astragalus root-acanthopanax sheet (48/box), lot number: 20071202, Hei Long group ancient cooking vessel Hengsheng, Qiqihar pharmaceutcal corporation, Ltd.
2.2 method
2.2.1 india ink is got in the preparation of india ink, and jolting, to evenly, is diluted 4 times with 1% gelatin solution and is for experiment repeatedly.
2.2.2 experiment is got male mice and is divided at random 7 groups, and 10 every group, blank group, positive drug matched group (giving astragalus root-acanthopanax sheet 4.80g crude drug/kg), astragalus root-acanthopanax soluble powder embodiment 1-5 group (giving respectively 4.80 crude drugs/kg).Each administration group gastric infusion, blank group gives the normal saline of respective volume amount, and every day 1 time, 0.1ml/10g, continuous 5 days, after last administration 24 hours, injects the india ink 0.1ml/10g of dilution in caudal vein.After injecting prepared Chinese ink, within 30 seconds and 6 minutes, get blood 0.025ml with getting blood suction pipe from mouse orbit rear vein beard, be blown at once 0.1% Na
2cO
3in liquid 2ml, suction pipe sucks, blows out for several times in this liquid, and the blood adhering to fully to wash out suction pipe wall, gets blood complete, is dissolved in 2ml0.1% Na with 0.025ml normal mouse blood
2cO
3liquid school zero, spectrophotometer (675nm) is measured absorbance.Sacrificed by decapitation mice, weighs, and extraction thymus and spleen are weighed.Calculate thymus or spleen index, phagocytic index K and engulf coefficient.
2.3 result
2.3.1 the impact on thymus, index and spleen index
The results are shown in Table 4.Astragalus root-acanthopanax soluble powder embodiment 1-5 group is compared with blank group, and thymus index is without significant difference; Astragalus root-acanthopanax soluble powder embodiment 1-5 group spleen index compares with blank group, and there were significant differences
.
With the comparison of blank group: * P<0.05, * * P<0.01
2.3.2 the impact on RES phagocytic function
Compared with blank group, astragalus root-acanthopanax soluble powder embodiment 1-5 group K value and α value are all shown in obviously to increase and (distinguish P<0.05, P<0.01), especially best with the embodiment 1-3 group effect in processing range, prompting astragalus root-acanthopanax soluble powder can strengthen the phagocytic function (the results are shown in Table 5) of mice RES.
With the comparison of blank group: * P<0.05, * * P<0.01
2.4 brief summary
Astragalus root-acanthopanax soluble powder can strengthen the phagocytic function of mice RES, can increase adult rats spleen weight.
3, the impact on the mice normal pressure resistant anoxia time-to-live
3.1 material
3.1.1 animal mice, body weight: 18～22g, is provided by University Of Nanchang's medical college Experimental Animal Center.
3.1.2 equipment 200ml ground wide mouthed bottle, stopwatch.
3.1.3 medicine and reagent astragalus root-acanthopanax soluble powder (100g/ bag, 1.6 crude drugs/g), lot number: 20080115, Jiangxi Zhongcheng TCM Extract Co., Ltd. produces.Astragalus root-acanthopanax sheet (48/box), lot number: 20071202, Hei Long group ancient cooking vessel Hengsheng, Qiqihar pharmaceutcal corporation, Ltd.Sodium hydroxide, calcium carbonate, vaseline etc. are analytical pure.
3.2 method
Choose 70 of the healthy mices of body weight 18～22g, male and female dual-purpose, weigh respectively, numbering, be divided into 7 groups by body weight and sex, i.e. normal saline group, positive drug matched group (giving astragalus root-acanthopanax sheet 4.80g crude drug/kg), astragalus root-acanthopanax soluble powder embodiment 1-5 group (giving respectively 4.80g crude drug/kg).Each administration group gastric infusion, every day 1 time, each 0.1ml/10g, successive administration 5 days, normal saline group, waits the normal saline of capacity.After last administration 30 minutes, mice is put into the wide mouthed bottle that fills 15g sodium hydroxide and 15g calcium carbonate, each 1 every group, with vaseline, by bottle sealing, timing immediately, observes the mouse survival time to cease breathing as standard.
The time-to-live (the results are shown in Table 6) of 3.3 result astragalus root-acanthopanax soluble powders under can significant prolongation mice normobaric hypoxia environment.
With the comparison of normal saline group: * P<0.05, * * P<0.01
3.4 brief summary
This experimental study shows that the astragalus root-acanthopanax soluble powder that the present invention makes has the effect that strengthens mice normal pressure resistant anoxia ability.
4, the impact on mice swimming time
4.1 material
4.1.1 animal mice, body weight: 18～22g, is provided by University Of Nanchang's medical college Experimental Animal Center.
4.1.2 the glass jar of equipment 50cm × 30cm × 25cm, heavy burden thing (each 2g), thermometer, stopwatch.
4.1.3 medicine and reagent astragalus root-acanthopanax soluble powder (100g/ bag, 1.6g crude drug/g), lot number: 20080115, Jiangxi Zhongcheng TCM Extract Co., Ltd. produces.Astragalus root-acanthopanax sheet (48/box), lot number: 20071202, Hei Long group ancient cooking vessel Hengsheng, Qiqihar pharmaceutcal corporation, Ltd.
4.2 method
Get 70 of normal mouses, body weight 18～22g, male and female half and half, divide 7 groups at random, blank group, positive drug matched group (giving astragalus root-acanthopanax sheet 4.80g crude drug/kg), astragalus root-acanthopanax soluble powder embodiment 1-5 group (giving respectively 4.80g crude drug/kg).Each administration group gastric infusion, every day 1 time, each 0.1ml/10g, successive administration 5 days, blank group gives the normal saline of corresponding dosage.After last administration 30 minutes, the load galvanized wire of 7% body weight of mouse tail root, puts water swimming, observes mice and swims to power and exhaust (can not float for 10 seconds under water), the swimming time that this time is mice.
4.3 the results are shown in Table 7.Result astragalus root-acanthopanax soluble powder can significant prolongation mice swimming time, illustrates that it has obvious anti-stress (fatigue) effect.
With matched group comparison: * * P<0.01, * P<0.05
4.4 brief summary
This experimental study shows that the astragalus root-acanthopanax soluble powder that the present invention makes has obvious anti-stress effect.
5, conclusion
The astragalus root-acanthopanax soluble powder that the present invention makes has certain digestion promoting effect, immunological enhancement, anti-stress effect.The therapeutic effect of embodiment 1-3 in processing range of the present invention is obviously better than embodiment 4,5 and the astragalus root-acanthopanax sheet outside processing range of the present invention, visible employing dosage form of the present invention and specific technique, can be used for the treatment of the disease such as immunocompromised and anti-stress of poultry greatly effectively.
Claims (4)
1. a poultry astragalus root-acanthopanax soluble powder, is characterized by: the raw material by following mass fraction is made: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, glucose 6-8 part.
2. a kind of poultry astragalus root-acanthopanax soluble powder as claimed in claim 1, it is characterized by: preparation method is: the Radix Astragali decocts with water 2 times, each 2.5-3.5 hour, the quality of the 1st water is 7.5-8.5 times of Radix Astragali quality, the quality of the 2nd water is 5.5-6.5 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.18-1.22 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water each 3 hours 2 times after pulverizing, the quality of the 1st water is 9.5-10.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 7.5-8.5 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filter, filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.18-1.22; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
3. a kind of poultry astragalus root-acanthopanax soluble powder as claimed in claim 1, is characterized by: the raw material by following mass fraction is made: 6 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 7 parts of glucoses.
4. a kind of poultry astragalus root-acanthopanax soluble powder as claimed in claim 3, it is characterized by: preparation method is: the Radix Astragali decocts with water 2 times, each 3 hours, the quality of the 1st water is 8 times of Radix Astragali quality, the quality of the 2nd water is 6 times of Radix Astragali quality, merges 2 times decocting liquid, filters, filtrate decompression is condensed into the extractum of relative density 1.20 under 60 DEG C of conditions, for subsequent use; Radix Et Caulis Acanthopanacis Senticosi decocts with water 2 times after pulverizing, and each 3 hours, the quality of the 1st water was 10 times of Radix Et Caulis Acanthopanacis Senticosi quality, and the quality of the 2nd water is 8 times of Radix Et Caulis Acanthopanacis Senticosi quality, merges 2 times decocting liquid, filters, and filtrate is condensed into the extractum that under 60 DEG C of conditions, relative density is 1.20; Merge above-mentioned two kinds of extractum, spraying is dry, adds glucose, mixes, and to obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890212A (en) * | 2015-12-18 | 2017-06-27 | 洛阳惠中兽药有限公司 | Application of the slender acanthopanax stilbene Chinese medicine composition in prevention and treatment porcine respiratory disease syndrome |
| CN109568384A (en) * | 2018-12-31 | 2019-04-05 | 洛阳汉德生物科技有限公司 | A kind of preparation method of birds toxin expelling antidiarrheal healthy veterinary drug |
| CN111494499A (en) * | 2020-04-26 | 2020-08-07 | 江西中成中药原料有限公司 | Astragalus membranaceus and acanthopanax senticosus soluble powder for poultry |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890212A (en) * | 2015-12-18 | 2017-06-27 | 洛阳惠中兽药有限公司 | Application of the slender acanthopanax stilbene Chinese medicine composition in prevention and treatment porcine respiratory disease syndrome |
| CN109568384A (en) * | 2018-12-31 | 2019-04-05 | 洛阳汉德生物科技有限公司 | A kind of preparation method of birds toxin expelling antidiarrheal healthy veterinary drug |
| CN111494499A (en) * | 2020-04-26 | 2020-08-07 | 江西中成中药原料有限公司 | Astragalus membranaceus and acanthopanax senticosus soluble powder for poultry |
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