CN102038857B - Method for preparing Chinese medicinal composition for treating child dyspepsia caused by overeating - Google Patents
Method for preparing Chinese medicinal composition for treating child dyspepsia caused by overeating Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating child spleen and stomach injury caused by improper diet, a preparation method and a quality control method. The medicinal composition comprises the following raw medicaments: astragalus, large-headed atractylodes rhizome, dried orange peel, dwarf lilyturf tuber, baikal skullcap root, hawthorn and radish seed. The preparation method comprises the following steps of: soaking the baikal skullcap root into water in an amount which is 8 to 12 times that of the baikal skullcap root, decocting the baikal skullcap root for 2 to 4 times and 1 to 4 hours; soaking the astragalus, large-headed atractylodes rhizome, dwarf lilyturf tuber, hawthorn and radish seed into water in an amount which is 8 to 12 times that of the soaked medicaments for 1 to 3 hours, and decocting for 2 to 4 times and 1 to 4 hours; extracting the dried orange peel for 2 to 4 times and 1 to 3 hours by using 1 percent Na2CO3 in an amount which is 7 to 12 times that of the dried orange peel; and combining the decoction, filtering the decoction, concentrating the filtrate to obtain clear paste with relative density of 1.01 to 1.05 (at 60 DEG C), refrigerating and filtering. The medicinal composition for treating the child spleen and stomach injury caused by improper diet has good curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition method for preparing, particularly relate to a kind of Chinese medicine composition method for preparing that pediatric diet does not save impairing the spleen and stomach of treating.
Background technology
Anorexia is the common a kind of miscellaneous diseases of children's, and the inappetence, the appetite that mainly show as the long period obviously reduce, even refusing to eat.Only child's father and mother lack the experience of child-bearing now, and some young father and mother fears that the child of oneself does not have enough to eat, length is not fat, so at all costs; Eat a large amount of high protein, high-carbonhydrate diet tonic to child, a fish, meat are drunk various Sugared beverages; Injure the tender and lovely gastrointestinal of child, make gastrointestinal can not normal stool, absorption, in the course of time; Appetite must descend, and causes anorexia, has a strong impact on growth promoter.
Ministry standard discloses valiant fighter's digestion promoting oral liquid, and prescription and technology are following:
[prescription] Radix Astragali 200g Rhizoma Atractylodis Macrocephalae (parched with bran) 100g Pericarpium Citri Reticulatae 100g
200g Radix Scutellariae 100g Fructus Crataegi Radix Ophiopogonis (stir-fry) 100g
Semen Raphani (stir-fry) 100g
[method for making] above seven flavors, decocte with water three times, 3 hours for the first time, second and third time each 2 hours, collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys), and cold preservation 48 hours filters.Filtrating adds refined honey 900g, sorbic acid 1.5 (adding the suitable quantity of water thermosol), and water adjustment total amount stirs to 3000ml, leaves standstill 48 hours, gets supernatant, embedding, sterilization promptly gets.
The present invention is based on the improvement of method for preparing, and new product has more outstanding drug effect.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition method for preparing that pediatric diet does not save impairing the spleen and stomach of treating.
The present invention seeks to realize through following technical scheme:
A kind ofly treat the method for preparing that pediatric diet does not save the Chinese medicine composition of impairing the spleen and stomach, this method comprises the steps:
Choose following crude drug:
The Radix Astragali 20-120 weight portion Rhizoma Atractylodis Macrocephalae (parched with bran) 10-100 weight portion Pericarpium Citri Reticulatae 10-100 weight portion
10-100 weight portion Radix Scutellariae 10-100 weight portion Fructus Crataegi Radix Ophiopogonis (stir-fry) 10-100 weight portion
Semen Raphani (stir-fry) 10-100 weight portion;
Doubly measure boiling water with 8-12 and soak Radix Scutellariae, decoct 2-4 time, decocted 1-4 hour, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 8-12 times of water gaging to be soaked 1-3 hour, decocted 2-4 time, decocted 1-4 hour, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract 2-4 time, each 7-12 doubly measures and extracted 1-3 hour; Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation filters, and processes the acceptable any conventional dosage form of pharmaceutics by the preparation process of routine, comprises capsule, tablet, granule, gel, oral liquid.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
A kind ofly treat the method for preparing that pediatric diet does not save the Chinese medicine composition oral liquid of impairing the spleen and stomach, this method comprises the steps:
Choose following crude drug:
The Radix Astragali 66.7 weight portion Rhizoma Atractylodis Macrocephalaes (parched with bran) 33.3 weight portion Pericarpium Citri Reticulataes 33.3 weight portions
Radix Ophiopogonis 66.7 weight portion Radix Scutellariaes, 33.3 weight portion Fructus Crataegis (stir-fry), 33.3 weight portions
Semen Raphani (stir-fry) 33.3 weight portions
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation 48 hours filters, and makes oral liquid.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The comparative efficacy test of experimental example 1 different process
1, mice gastric emptying experiment
Medicine:
Of the present invention group: press the preparation of embodiment 1 method.
Matched group: Radix Astragali 66.7g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 33.3g, Pericarpium Citri Reticulatae 33.3g, Radix Ophiopogonis 66.7g Radix Scutellariae 33.3g, Fructus Crataegi (stir-fry) 33.3g, Semen Raphani (stir-fry) 33.3g; Decocte with water three times, 3 hours for the first time, second, third time each 2 hours, collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys), and cold preservation 48 hours filters.Filtrating adds refined honey 300g, sorbic acid 0.5g (adding the suitable quantity of water thermosol), and water adjustment total amount stirs to 1000ml, leaves standstill 48 hours, gets supernatant, fill, sterilization promptly gets.
Get 40 of body weight 18～22g mices, male and female half and half are divided into 4 groups at random, prepare gastric emptying with epinephrine and suppress model, press 40mL/kg oral dose administration 1 time every day.Fasting is 12 hours before the administration, and each organized mouse subcutaneous injection epinephrine 0.5mg/kg except that the normal control group in 1 hour 45 minutes after the administration, irritates the stomach phenol red solution after 15 minutes, puts to death after 30 minutes, measures the phenol red residual rate of stomach as stated above respectively, and the result sees the following form 1
The influence of table 1 pair epinephrine load mice gastric emptying
With of the present invention group of comparison * P＜0.05
The result shows: there were significant differences for prepared medicine of the present invention and control drug group, and of the present invention group has significant facilitation to epinephrine load mice gastric emptying.
2, the intestinal propulsion of mice is tested
Get 30 of body weight 18～22g mices, male and female half and half are divided into model group, of the present invention group and matched group at random; Press 40mL/kg oral dose administration 1 time every day, model group gives the distilled water of equivalent, and administration is after 3 days; Fasting 14h irritates stomach 10% activated carbon suspension 10mL/kg (preparing with normal saline) behind last administration 1h, for each treated animal, behind the 25min mice is taken off neck and puts to death; Cut open the belly and peel off gastrointestinal tract, be placed on the glass plate.Measure pylorus to ileocecus total length and pylorus distance, calculate carbon powder with formula and advance percentage rate to the carbon powder forward position.Check the significance of respectively organizing difference with t, the result sees table 2.
The intestinal propulsion test of table 2 pair mice
Annotate: compare * * P＜0.01 with blank control group.
Table 2 is the result show, than difference statistical significance (P＜0.01) arranged with blank control group, points out of the present invention group to compare with matched group that there were significant differences promoting intestinal motility, shows of the present invention group of effect with tangible promotion small intestinal peristalsis.
The extraction of Hesperidin experiment in experimental example 2 Pericarpium Citri Reticulataes
1. experiment purpose:
On the basis of existing extraction equipment, adjusting extracting mode, is to investigate index with the content of hesperidin,
Adopt different extraction conditions that the Pericarpium Citri Reticulatae medical material is extracted, calculate the whole bag of tricks and extract the rate of transform.
2. experimental technique:
2.1 medical material processing method:
Contain this flavonoid material of Hesperidin in the Pericarpium Citri Reticulatae.
The processing method of Pericarpium Citri Reticulatae: break into pieces with one's fingers with hands.
1) the water extraction Hesperidin is three times: content of hesperidin in more each extracting solution, investigation needs the number of times of extraction.
Method: get the about 200g of Pericarpium Citri Reticulatae medical material (lot number: 20080311), solvent: water; Extraction time: 3 times; Extraction time is followed successively by: 2h, 1.5h, 1h; Solvent load is followed successively by: 8 times, and 6 times, 6 times.
Appearance 1 (for the first time): add water 1600ml (8 times of amounts) and extract 2h
Appearance 2 (for the second time): add water 1200ml (6 times of amounts) and extract 1.5h
Appearance 3 (for the third time): add water 1200ml (6 times of amounts) and extract 1.5h
Because the less deposition that causes of concentrated solution in above three experiments, its determination data is less than normal, thus done again one time by above method again, concentrated half the to extracting solution approximately, see whether deposition is influential to Hesperidin.
Appearance 4 (for the first time): add water 1600ml (8 times of amounts) and extract 2h
Appearance 5 (for the second time): add water 1200ml (6 times of amounts) and extract 1.5h
Appearance 6 (for the third time): add water 1200ml (6 times of amounts) and extract 1.5h
2) NaHCO of variable concentrations
3Solution and Na
2CO
3Solution extracts: investigate the influence of the difference of aqueous slkali to content of hesperidin in the extracting solution, confirm extracting solution.
Method: get the about 200g of Pericarpium Citri Reticulatae medical material (lot number: 20080311), solvent: 2%NaHCO
3Solution, 5%NaHCO
3Solution, 1%Na
2CO
3Solution.Solvent load all is 8 times of amounts, and extraction time all is 2h.
Alkali 1:2%NaHCO
3Solution 1600ml extracts 2h;
Alkali 2:5%NaHCO
3Solution 1600ml extracts 2h;
Alkali 3:1%Na
2CO
3Solution 1600ml extracts 2h.
3) 1%Na
2CO
3Solution extracts: confirm technological parameter.
Appearance 1: for the first time extract 2h with 1600ml (8 times), each is with 1200ml (6 times) extraction 1.5h for the second time, for the third time.
Appearance 2: for the first time extract 2h with 2000ml (10 times), each is with 1600ml (8 times) extraction 1.5h for the second time, for the third time.
2.2 detection method:
Chromatographic condition and system suitability experiment: use the RP-18 bonded silica gel to be filler; Methanol: acetic acid: water (35: 4: 61) is mobile phase; The detection wavelength is 283nm.Theoretical cam curve is calculated by the Hesperidin peak and is not less than 2000.
Hesperidin reference substance solution concentration: 0.252mg/ml.
The preparation of need testing solution: the about 0.5g of precision weighing concentrated solution supernatant, put in the 50ml volumetric flask, add methanol to scale, if any thing hard to tolerate then supersound process it is dissolved fully, shake up, filter and to get subsequent filtrate, promptly get.
3. experimental data and analysis:
3.1 water extraction:
The result shows: little with difference for the third time for the second time, be necessary to carry out extraction for the third time.
The amount of concentrated solution is influential to Determination of Hesperidin Content, and the last volume of concentrated solution is too little, is prone to cause Hesperidin to separate out, and it is better half that volume is about extracting solution.
3.2 Different Alkali solution extracts:
The result shows: 1%Na
2CO
3Content of hesperidin is much higher than 2%NaHCO in the extracting solution of solution
3Solution, 5%NaHCO
3Content of hesperidin in the extracting solution of solution is so extracting solution is used 1%Na
2CO
3Solution.
3.3 1%Na
2CO
3Solution extracts
The result shows: because of the reason of the easy suction of Pericarpium Citri Reticulatae, the consumption of extracting solution is many for the first time, and its effect is relatively good.
3.4 conclusion
The optimised process that extracts Hesperidin in the Pericarpium Citri Reticulatae that is obtained by experiment is: use 1%Na
2CO
3Solution extracts three times, extracts 2 hours with 10 times of amounts for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.
Following embodiment all can realize the described effect of above-mentioned experimental example
The specific embodiment
Embodiment 1: oral liquid
The Radix Astragali 66.7g Rhizoma Atractylodis Macrocephalae (parched with bran) 33.3g Pericarpium Citri Reticulatae 33.3g 66.7g Radix Ophiopogonis
Radix Scutellariae 33.3g Fructus Crataegi (stir-fry) 33.3g Semen Raphani (stir-fry) 33.3g
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation 48 hours filters.Filtrating adds refined honey 300g, sorbic acid 0.5g (adding the suitable quantity of water thermosol), and water adjustment total amount stirs to 1000ml, leaves standstill 48 hours, gets supernatant, fill, sterilization promptly gets.Specification: every dress 10ml.
Embodiment 2: oral liquid
The Radix Astragali 45g Rhizoma Atractylodis Macrocephalae (parched with bran) 45g Pericarpium Citri Reticulatae 45g 65g Radix Ophiopogonis
Radix Scutellariae 45g Fructus Crataegi (stir-fry) 45g Semen Raphani (stir-fry) 70g;
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation 48 hours filters.Filtrating adds refined honey 300g, sorbic acid 0.5g (adding the suitable quantity of water thermosol), and water adjustment total amount stirs to 1000ml, leaves standstill 48 hours, gets supernatant, fill, sterilization promptly gets.Specification: every dress 10ml
Embodiment 3: oral liquid
Radix Astragali 50g art (parched with bran) 55g Pericarpium Citri Reticulatae 65g 60g Radix Ophiopogonis
Radix Scutellariae 55g short, bristly hair or beard (stir-fry) 55g Semen Raphani (stir-fry) 70g;
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation 48 hours filters.Filtrating adds refined honey 300g, sorbic acid 0.5g (adding the suitable quantity of water thermosol), and water adjustment total amount stirs to 1000ml, leaves standstill 48 hours, gets supernatant, fill, sterilization promptly gets.Specification: every dress 10ml
Embodiment 4: drop pill
The Radix Astragali 66.7g Rhizoma Atractylodis Macrocephalae (parched with bran) 33.3g Pericarpium Citri Reticulatae 33.3g 66.7g Radix Ophiopogonis
Radix Scutellariae 33.3g Fructus Crataegi (stir-fry) 33.3g Semen Raphani (stir-fry) 33.3g
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours.Collecting decoction filters, and filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃), and cold preservation 48 hours filters; Filtrating is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys), and cold preservation 48 hours filters, and concentrates; Vacuum drying is crushed to 120 orders, with an amount of fused polyethylene glycol 6000 or 4000, mix homogeneously; 60～80 ℃ of insulations, constant speed splash in 12 ℃～15 ℃ the liquid paraffin, with the drop pill drop that is shaped to the greatest extent and the erasing liquor paraffin body, promptly get.
Claims (4)
1. treat the method for preparing that pediatric diet does not save the Chinese medicine composition of impairing the spleen and stomach for one kind, it is characterized in that this method comprises the steps:
Choose following crude drug:
Radix Astragali 20-120 weight portion Rhizoma Atractylodis Macrocephalae (parched with bran) 10-100 weight portion Pericarpium Citri Reticulatae 10-100 weight portion
Radix Ophiopogonis 10-100 weight portion Radix Scutellariae 10-100 weight portion Fructus Crataegi (parched) 10-100 weight portion
Fry
Semen Raphani 10-100 weight portion;
Doubly measure boiling water with 8-12 and soak Radix Scutellariae, decoct 2-4 time, decocted 1-4 hour, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 8-12 times of water gaging to be soaked 1-3 hour, decocted 2-4 time, decocted 1-4 hour, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract 2-4 time, each 7-12 doubly measures and extracted 1-3 hour; Collecting decoction filters, and filtrating is concentrated into 60 ℃, and to survey relative densities be 1.01～1.05 clear paste, and cold preservation filters.
2. the method for claim 1 is characterized in that processing capsule, tablet, granule, gel or oral liquid by the preparation process of routine.
3. the method for claim 1 is characterized in that this method is:
Choose following crude drug:
The Radix Astragali 66.7 weight portion Rhizoma Atractylodis Macrocephalae (parched with bran) 33.3 weight portion Pericarpium Citri Reticulataes 33.3 weight portions
Radix Ophiopogonis 66.7 weight portion Radix Scutellariaes, 33.3 weight portion Fructus Crataegi (parched), 33.3 weight portions
Semen Raphani (parched) 33.3 weight portions
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, for the first time 10 times of amounts were extracted 2 hours, second and third time each with 8 times of amounts, each extracted 1.5 hours, collecting decoction filters, filtrating is concentrated into 60 ℃, and to survey relative densities be 1.01～1.05 clear paste, cold preservation 48 hours, filtration makes oral liquid.
4. a Chinese medicine composition promotes the application in the small intestinal peristalsis medicine in preparation, and said Chinese medicine composition is following method preparation:
Choose following crude drug:
Radix Astragali 66.7g Rhizoma Atractylodis Macrocephalae (parched with bran) 33.3g Pericarpium Citri Reticulatae 33.3g 66.7g Radix Ophiopogonis
Radix Scutellariae 33.3g Fructus Crataegi (parched) 33.3g Semen Raphani (parched) 33.3g;
Soak Radix Scutellariae with 10 times of amount boiling water, decoct three times, decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Crataegi, Semen Raphani add 10 times of water gagings and soak decoction in 2 hours three times; Decocted 3 hours for the first time; Second and third time adds 8 times of water gagings, and each decocted 2 hours, and Pericarpium Citri Reticulatae is used 1%Na
2CO
3Extract three times, 10 times of amounts were extracted 2 hours for the first time, and second and third time is respectively with 8 times of amounts, and each extracted 1.5 hours, collecting decoction; Filter, filtrating is concentrated into 60 ℃, and to survey relative densities be 1.01～1.05 clear paste, and cold preservation 48 hours filters, and filtrating adds refined honey 300g; The sorbic acid 0.5g that adds the suitable quantity of water thermosol, water adjustment total amount stirs to 1000ml, leaves standstill 48 hours; Get supernatant, fill, sterilization promptly gets.
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| CN102743639B (en) * | 2012-07-03 | 2014-06-25 | 宁波市鄞州福瑞达生物科技有限公司 | Health care composition for improving appetite of patients in chemotherapy |
| CN111035715A (en) * | 2020-01-06 | 2020-04-21 | 广东利泰制药股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal function and regulating intestinal flora |
| CN115475210A (en) * | 2022-09-16 | 2022-12-16 | 北京亚东生物制药有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
| CN115869373A (en) * | 2022-12-30 | 2023-03-31 | 江中药业股份有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
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| CN1611257A (en) * | 2004-03-02 | 2005-05-04 | 贵州恒和制药有限公司 | Childreu-care digestive capsule and its preparing method |
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