CN107854612A - A kind of medicine for treating constipation and preparation method thereof - Google Patents

A kind of medicine for treating constipation and preparation method thereof Download PDF

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Publication number
CN107854612A
CN107854612A CN201711092614.7A CN201711092614A CN107854612A CN 107854612 A CN107854612 A CN 107854612A CN 201711092614 A CN201711092614 A CN 201711092614A CN 107854612 A CN107854612 A CN 107854612A
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parts
medicine
chinese medical
constipation
medical extract
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罗昌兴
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention belongs to pharmaceutical technology field, specifically discloses a kind of medicine for treating constipation and preparation method thereof, counts in parts by weight, is made up of following raw material：Than can 100 150 parts of husky 80 120 parts of pyridine, 40 70 parts of starch, 13 parts of magnesium stearate, 0.5 2 parts of dodecyl sodium sulfate and Chinese medical extract.By the way of the medicine of the present invention is combined using Chinese and Western, can not only fast and effectively solve the problems, such as constipation, enteron aisle can also be adjusted, avoid side effect caused by Western medicine and be discontinued repeatedly the problem of, be it is a kind of safely, effectively, have no side effect, the medicine of no dependence.

Description

A kind of medicine for treating constipation and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of medicine for treating constipation and preparation method thereof.
Background technology
Constipation (constipation) refers to that stool interval is reduced, and times of defecation is less than 2-3 times in one week, or 2-3 days Just defecate 1 time, excrement amount is referred to as constipation when few and dry and hard.But there are a few peoples to be always usually 2-3 talentes stool 1 time, and defecate Character is normal, and such a situation is not considered as constipation；For same people, such as stool is from 1 time a day or every 2 days 1 time is changed into 2 days When above or the longer time begins to defecate 1 time, constipation should be regarded as.Enough attention are must be accorded to constipation patient, are occurred with finding The reason for constipation.
The harm of constipation is summed up, and has 10 broad aspects：1. influence beauty：Constipation patient is detained intestines due to the excrement block length time Road, abnormal fermentation, largely harmful toxin can be produced after corrupt, easily raw acne, facial pigmentation, fash etc..2. cause fertilizer It is fat：Toxin causes large intestine oedema, and lower part of the body blood circulation slows down, and easily forms pyriform stature and fat belly.3. produce body odor：Toxin Aggregation can cause halitosis and body odor.4. distaste for food：Constipation can make belly turgor, produce nausea, apocleisis, food and it is tasteless.⑤ Neurasthenia：Constipation patient can have the symptoms such as irritated, confused and worried, insomnia.6. trigger dysmenorrhoea：Chronic constipation patient is due to long-term Pelvic muscle stimulates, and can often trigger dysmenorrhoea.7. sexual hypoesthesia：Prolonged constipation patient can have sexual hypoesthesia.8. complication：Constipation Patient can concurrently anal intestine disease, such as hemorrhoid, anal fissure, the prolapse of rectum.In addition, also it is susceptible to suffer from the anaphylactias such as nettle rash, asthma.⑨ Induce cancer：Harmful toxins persistently stimulate intestinal mucosa, are easily caused colorectal cancer, still induce breast cancer in addition.10. cause to die suddenly：It is special It is not the cardiovascular patients such as hypertension, coronary heart disease, difficult defecation can steeply rise blood pressure, cause apoplexy or even die suddenly.
At present, the medicine (including Western medicine and Chinese medicine) for clinically constantly having the new habitual intractable constipation for the treatment of occurs, But these fail to reach real gratifying effect.The Chinese and Western medicine compound drug for develop a kind of high-efficiency low-toxicity, treating both principal and secondary aspect of disease It is still clinical eager needs.
The content of the invention
In order to solve the above problems, the present invention provides a kind of medicine for treating constipation and preparation method thereof, and this medicine combines Chinese and western medical theory, rational proportion, the medicine of present invention treatment constipation is formed, overcomes Western medicine while effectively treatment constipation Side effect, be discontinued repeatedly the problem of, reach the purpose treated both principal and secondary aspect of disease.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of medicine for treating constipation, is counted in parts by weight, It is made up of following raw material：Than can husky pyridine 80-120 parts, starch 40-70 parts, magnesium stearate 1-3 parts, dodecyl sodium sulfate 0.5-2 Part and Chinese medical extract 100-150 parts.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
Preferably, a kind of medicine for treating constipation, the Chinese medical extract, is counted in parts by weight, is made up of following raw material： Radix Codonopsis 20-30 parts, wilsonii 20-30 parts, native the root of straight ladybell 20-30 parts, Ficus fulva Reinw 10-15 parts, tuber of multiflower knotweed 10-15 parts, saline cistanche 10-15 Part, japanese plum seed 10-15 parts, Snakegourd Fruit 10-15 parts, peach kernel 10-15 parts, Fructus Sophorae 10-15 parts and bletilla striata 5-10 parts.
Preferably, a kind of medicine for treating constipation, the preparation method of the Chinese medical extract comprise the following steps：
Step 1：Take Radix Codonopsis 20-30 parts, wilsonii 20-30 parts, native the root of straight ladybell 20-30 parts, Ficus fulva Reinw 10-15 parts, tuber of multiflower knotweed 10- 15 parts, saline cistanche 10-15 parts, japanese plum seed 10-15 parts, Snakegourd Fruit 10-15 parts, peach kernel 10-15 parts, Fructus Sophorae 10-15 parts and bletilla striata 5- 10 parts；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：(3-5) is mixed, and decocts 30-50 minutes, is filtered, filter Liquid is spray-dried to obtain Powder Extract, as Chinese medical extract.
The present invention also provides a kind of preparation method for the medicine for treating constipation, concretely comprises the following steps：In pharmaceutical grade clean area, Take than can husky pyridine 80-120 parts, starch 40-70 parts, magnesium stearate 1-3 parts, dodecyl sodium sulfate 0.5-2 parts and traditional Chinese medicine extraction Thing 100-150 parts, after machinery mixes, ultra-pure water is added, is placed in pharmacy mixer, mixes 4-8 minutes, tabletting and drying, piece Agent specification is 1.2g/ pieces.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention combines Chinese and western medical theory, and selection function medicine carries out rational proportion, and present invention treatment constipation is made Medicine.By the way of the medicine of the present invention is combined using Chinese and Western, can not only fast and effectively solve the problems, such as constipation, additionally it is possible to Enteron aisle is adjusted, is that one kind safely, effectively, without pair is made the problem of avoiding side effect caused by Western medicine and be discontinued repeatedly With the medicine of, no dependence.
Embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit Determine the scope of the present invention.
Embodiment 1
A kind of preparation for the medicine for treating constipation, is concretely comprised the following steps：In pharmaceutical grade clean area, take than can husky pyridine 80g, form sediment Powder 50g, magnesium stearate 3g, dodecyl sodium sulfate 2g and Chinese medical extract 150g, after machinery mixes, ultra-pure water is added, is placed In pharmacy mixer, mix 5 minutes, tabletting and drying, tablet format are 1.2g/ pieces.
Wherein, Chinese medical extract is made by following methods：
Step 1：Take Radix Codonopsis 20g, wilsonii 20g, native the root of straight ladybell 30g, Ficus fulva Reinw 15g, tuber of multiflower knotweed 10g, saline cistanche 10g, plum pit Benevolence 15g, Snakegourd Fruit 15g, peach kernel 10g, Fructus Sophorae 10g and bletilla striata 10g；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：3 mixing, are decocted 50 minutes, filtering, and filtrate spraying is dry It is dry to obtain Powder Extract, as Chinese medical extract.
Embodiment 2
A kind of preparation for the medicine for treating constipation, is concretely comprised the following steps：In pharmaceutical grade clean area, take than can husky pyridine 120g, Starch 70g, magnesium stearate 2g, dodecyl sodium sulfate 2g and Chinese medical extract 100g, after machinery mixes, ultra-pure water is added, is put Put in pharmacy mixer, mix 8 minutes, tabletting and drying, tablet format are 1.2g/ pieces.
Wherein, Chinese medical extract is made by following methods：
Step 1：Take Radix Codonopsis 30g, wilsonii 30g, native the root of straight ladybell 20g, Ficus fulva Reinw 10g, tuber of multiflower knotweed 15g, saline cistanche 15g, plum pit Benevolence 10g, Snakegourd Fruit 10g, peach kernel 15g, Fructus Sophorae 15g and bletilla striata 5g；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：5 mixing, are decocted 30 minutes, filtering, and filtrate spraying is dry It is dry to obtain Powder Extract, as Chinese medical extract.
Embodiment 3
A kind of preparation for the medicine for treating constipation, is concretely comprised the following steps：In pharmaceutical grade clean area, take than can husky pyridine 100g, Starch 60g, magnesium stearate 3g, dodecyl sodium sulfate 1.5g and Chinese medical extract 120g, after machinery mixes, ultra-pure water is added, Place in pharmacy mixer, mix 4 minutes, tabletting and drying, tablet format are 1.2g/ pieces.
Wherein, Chinese medical extract is made by following methods：
Step 1：Take Radix Codonopsis 25g, wilsonii 25g, native the root of straight ladybell 25g, Ficus fulva Reinw 12g, tuber of multiflower knotweed 12g, saline cistanche 12g, plum pit Benevolence 12g, Snakegourd Fruit 12g, peach kernel 12g, Fructus Sophorae 12g and bletilla striata 8g；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：4 mixing, are decocted 45 minutes, filtering, and filtrate spraying is dry It is dry to obtain Powder Extract, as Chinese medical extract.
Embodiment 4：
A kind of preparation for the medicine for treating constipation, is concretely comprised the following steps：In pharmaceutical grade clean area, take than can husky pyridine 110g, Starch 40g, magnesium stearate 1g, dodecyl sodium sulfate 0.5g and Chinese medical extract 130g, after machinery mixes, ultra-pure water is added, Place in pharmacy mixer, mix 5 minutes, tabletting and drying, tablet format are 1.2g/ pieces.
Wherein, Chinese medical extract is made by following methods：
Step 1：Take Radix Codonopsis 25g, wilsonii 25g, native the root of straight ladybell 25g, Ficus fulva Reinw 12g, tuber of multiflower knotweed 12g, saline cistanche 12g, plum pit Benevolence 12g, Snakegourd Fruit 12g, peach kernel 12g, Fructus Sophorae 12g and bletilla striata 8g；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：4 mixing, are decocted 45 minutes, filtering, and filtrate spraying is dry It is dry to obtain Powder Extract, as Chinese medical extract.
Embodiment 5：
A kind of preparation for the medicine for treating constipation, is concretely comprised the following steps：In pharmaceutical grade clean area, take than can husky pyridine 90g, form sediment Powder 55g, magnesium stearate 2g, dodecyl sodium sulfate 2g and Chinese medical extract 125g, after machinery mixes, ultra-pure water is added, is placed In pharmacy mixer, mix 5 minutes, tabletting and drying, tablet format are 1.2g/ pieces.
Wherein, Chinese medical extract is made by following methods：
Step 1：Take Radix Codonopsis 25g, wilsonii 25g, native the root of straight ladybell 25g, Ficus fulva Reinw 12g, tuber of multiflower knotweed 12g, saline cistanche 12g, plum pit Benevolence 12g, Snakegourd Fruit 12g, peach kernel 12g, Fructus Sophorae 12g and bletilla striata 8g；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：4 mixing, are decocted 45 minutes, filtering, and filtrate spraying is dry It is dry to obtain Powder Extract, as Chinese medical extract.
The medicine that above-described embodiment 5 is prepared to the treatment constipation of gained carries out pharmacological experiment：
1st, acute toxicity testing
With the drug study of the obtained treatment constipation of the embodiment of the present invention 5, by the way of gastric infusion, in 24 hours Twice, every minor tick 8 hours, 1.2g/kg is administered in successive administration every time, daily accumulative administration 2.4g/kg, equivalent to the clinical use of people 60 times of medicine.In administration 7 days, the activity of mouse, feed, normal, the well-grown of excretion, hair color light.As a result show：This hair Mingzhi treats the medicine of constipation without acute toxic reaction.
2nd, long term toxicity test
With the drug study of the obtained treatment constipation of the embodiment of the present invention 5, by the way of gastric infusion, successive administration 24 In week, twice daily, 1.2g/kg is administered every time, daily accumulative administration 2.4g/kg, equivalent to 60 times of people's clinical application.24 weeks Afterwards, the physiochemical indice of mouse, blood parameters have no significant effect, Systematic anatomy, organ coefficient and histopathological examination Also no abnormal pathological change, obvious change is also had no after being discontinued two weeks.As a result show, the present invention treatment constipation medicine without Toxic reaction, long-term prescription are safe and reliable.
3rd, clinical test
200 constipation patients, wherein male patient 102 are randomly selected, female patient 98 is age 24-75 year, average 47.1 years old age, course of disease 1-5.Symptom：Defecation time extends, and three days with last time, excrement dry, hard.Take of the invention real Apply the preparation of example 5 treatment constipation and medicine one week, once a day, each one, wherein there are 148 patients to cure, guarantee two Once, just matter turns profit to its defecation, unobstructed during solution, in short term without recurrence；30 conditions of patients take a turn for the better, in three days defecation once, just matter Turn profit, but defecation owes smooth.The effective percentage of the medicine for the treatment of constipation manufactured in the present embodiment is up to 89%.

Claims (4)

1. a kind of medicine for treating constipation, it is characterised in that count, be made up of following raw material in parts by weight：Than can husky pyridine 80- 120 parts, starch 40-70 parts, magnesium stearate 1-3 parts, dodecyl sodium sulfate 0.5-2 parts and Chinese medical extract 100-150 parts.
A kind of 2. medicine for treating constipation according to claim 1, it is characterised in that the Chinese medical extract, by weight Number meter, it is made up of following raw material：Radix Codonopsis 20-30 parts, wilsonii 20-30 parts, native the root of straight ladybell 20-30 parts, Ficus fulva Reinw 10-15 parts, Tuber of multiflower knotweed 10-15 parts, saline cistanche 10-15 parts, japanese plum seed 10-15 parts, Snakegourd Fruit 10-15 parts, peach kernel 10-15 parts, Fructus Sophorae 10-15 parts and Bletilla striata 5-10 parts.
3. according to a kind of any described medicines for treating constipation of claim 1-2, it is characterised in that the Chinese medical extract Preparation method comprises the following steps：
Step 1：Take Radix Codonopsis 20-30 parts, wilsonii 20-30 parts, native the root of straight ladybell 20-30 parts, Ficus fulva Reinw 10-15 parts, tuber of multiflower knotweed 10-15 Part, saline cistanche 10-15 parts, japanese plum seed 10-15 parts, Snakegourd Fruit 10-15 parts, peach kernel 10-15 parts, Fructus Sophorae 10-15 parts and bletilla striata 5-10 Part；
Step 2：It is 1 in mass ratio by the Chinese medicine of step 1 and water：(3-5) is mixed, and is decocted 30-50 minutes, filtering, filtrate spray Mist is dried to obtain Powder Extract, as Chinese medical extract.
4. a kind of preparation method for the medicine for treating constipation, it is characterised in that concretely comprise the following steps：In pharmaceutical grade clean area, take Than can husky pyridine 80-120 parts, starch 40-70 parts, magnesium stearate 1-3 parts, dodecyl sodium sulfate 0.5-2 parts and Chinese medical extract 100-150 parts, after machinery mixes, ultra-pure water is added, is placed in pharmacy mixer, mixes 4-8 minutes, tabletting and drying, tablet Specification is 1.2g/ pieces.
CN201711092614.7A 2017-11-08 2017-11-08 A kind of medicine for treating constipation and preparation method thereof Withdrawn CN107854612A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350660A (en) * 2018-10-29 2019-02-19 何凤姣 A kind of compound preparation of relax bowel and defecation and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350660A (en) * 2018-10-29 2019-02-19 何凤姣 A kind of compound preparation of relax bowel and defecation and preparation method thereof

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