CN104666702B - A kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction - Google Patents
A kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction Download PDFInfo
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Abstract
The invention belongs to pharmaceutical technology fields, and in particular to a kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction.The Chinese medicine composition is made of the bulk pharmaceutical chemicals of following weight proportion：20 60 parts of ginseng, 80 120 parts of Radix Astragali, 20 60 parts of pappy shell, 10 15 parts of cuttle bone, 80 120 parts of red halloysite, 40 80 parts of longan seed, 60 100 parts of myrobalan, 40 80 parts of corydalis tuber, 70 130 parts of nutmeg, 20 30 parts of the shell of areca nut, 30 40 parts of Fructus Aurantii, 20 30 parts of the seed of Oriental arborvitae.Preparation method of the present invention carries out the extraction of active ingredient by adjusting pH value, improves recovery rate.The present invention can fundamentally solve acute chronic enteritis, colitis, bowel dysfunction pathogenic factor by each raw material of compatibility of science, directly remove lesion, achieve the purpose that radical cure, the composition are small to stomach burden, safe and efficient, utilization ratio of drug is high and easy to use.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of to treat acute chronic enteritis, colitis, bowel dysfunction
Chinese medicine composition.
Background technology
Enteritis class disease is frequently-occurring disease and common disease, seriously affects the health of people, such disease stubbornness is refractory, sick
Journey length, easy recurrent exerbation.Due to patient's own digestive system functional disturbance, vital organs of the human body function is fallen ill with respect to disorder.Big portion
Divide the carry out anti-inflammation and sterilization of patient's abuse of antibiotics simply, does not have therapeutic effect not only but also destroy the normal of gastrointestinal tract
Flora, it is inconvenient and difficult to be brought to later conventional therapy, is caused with some other malpractice behaviors due to above
Keep disease stubbornness refractory, seriously threatens the health of the mankind.
In existing therapy, the carry out anti-inflammation and sterilization of most of patient's abuse of antibiotics simply destroys gastrointestinal tract
Normal flora, it is inconvenient and difficult to be brought to later conventional therapy, due to above and it is other some improper control
Treatment behavior causes disease stubbornness refractory, seriously threatens the health of the mankind.Due to patient's own digestive system functional disturbance, the five internal organs
Six internal organs function is fallen ill with respect to disorder.
The form of Chinese drug slowly effect of present treatment enteritis, medication time is long, and Western medicine dosage form is using anti-inflammatory, bactericide
Although object can improve in a short time, enteral beneficial bacterium is easily killed sometimes, causes bowel dysfunction.
Invention content
In view of the problems of the existing technology, to treat acute chronic enteritis, colitis, gut function disorderly the present invention provides a kind of
Random Chinese medicine composition, the composition stability is good, can mitigate stomach burden, safe and efficient, and utilization ratio of drug is high and uses
It is convenient.
The present invention also provides a kind of preparation method of Chinese medicine composition, drug absorption rate prepared by this method is good, utilizes
Rate is high.
Used technical solution is the present invention to achieve the goals above：
The present invention provides a kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction, the Chinese medicine groups
Object is closed to be made of the bulk pharmaceutical chemicals of following weight proportion：20-60 parts of ginseng, 80-120 parts of Radix Astragali, 20-60 parts of pappy shell, cuttlefish
10-15 parts of bone, 80-120 parts of red halloysite, 40-80 parts of longan seed, 60-100 parts of myrobalan, 40-80 parts of corydalis tuber, nutmeg 70-
130 parts, 20-30 parts of the shell of areca nut, 30-40 parts of Fructus Aurantii, 20-30 parts of the seed of Oriental arborvitae.
Further, the bulk pharmaceutical chemicals of optimization are：40 parts of ginseng, 110 parts of Radix Astragali, 45 parts of pappy shell, 15 parts of cuttle bone, red halloysite
100 parts, 60 parts of longan seed, 60 parts of myrobalan, 65 parts of corydalis tuber, 100 parts of nutmeg, 30 parts of the shell of areca nut, 30 parts of Fructus Aurantii, the seed of Oriental arborvitae 30
Part.
The Chinese medicine composition further includes synergy bulk pharmaceutical chemicals, and the synergy bulk pharmaceutical chemicals are one group or more in following three groups
Group：
First group：85 parts of Chinese actinidia root, 50 parts windproof, 60 parts of Cortex Magnoliae Officinalis, 25 parts of fructus amomi；
Second group：100 parts of rhizoma alismatis, 90 parts of Radix Codonopsis, 85 parts of Rhizoma Atractylodis Macrocephalae, 80 parts of granatum；
Third group：100 parts of Chinese cassia tree, 86 parts of Schisandra chinensis, 75 parts of the membrane of a chicken's gizzard.
The Chinese medicine composition of the present invention can be made into capsule（Stomach Yiganning capsule）, corresponding auxiliary material can also be added, piece is made
Agent, pill.Prepare that different dosage forms auxiliary material only used is different, medicament effective component or the same, therapeutic effect it is also identical or
It is approximate.The auxiliary material of tablet is starch, microcrystalline cellulose, pregelatinized starch, lactose, carboxyrnethyl starch sodium, hydroxypropyl methylcellulose, talcum
The auxiliary material of powder, magnesium stearate, pill is starch, microcrystalline cellulose, carboxyrnethyl starch sodium, hydroxypropyl methylcellulose, the auxiliary material of capsule
For starch, pregelatinized starch, carboxyrnethyl starch sodium, hydroxypropyl methylcellulose, magnesium stearate.
The present invention also provides a kind of preparation methods of Chinese medicine composition, include the following steps：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into fine powder, it is spare；
（2）The aqueous acetic acid that 8-14 times of pH value is 4.5-5.5, extraction 2 will be added in the remaining bulk pharmaceutical chemicals of parts by weight
Hour, filtering；
（3）The calcium hydroxide aqueous solution that 8-14 times of pH value is 8.0-8.5 will be added in filtered filter residue, extracts 2 hours,
Filtering；
（4）Above-mentioned filtered filtrate twice is merged, it is that be concentrated into relative density after neutrality be 1.05- to adjust pH value
1.20 thick paste gets dry extract after dry；
（5）Step will be added in dry cream（1）Middle fine powder is to get the Chinese medicine composition.
In inventive formulation raw material, the effect of each bulk pharmaceutical chemicals, is as follows：
The effect of ginseng has and reinforces vital energy, and prevent prolapse is promoted the production of body fluid, tranquilizing the mind, is intended to take off, internal lesion caused by overexertion is deficient, and burnout is received for the deficiency of vital energy
Slow-witted, vomiting, lingering diarrhea of defecating, shortness of breath, spontaneous perspiration, chronic cough and dyspnea of deficiency type quenches one's thirst, has a sleepless night, palpitation with fear, forgetful, impotence, frequent micturition, uterine bleeding etc. all
The card of deficiency of vital energy Tianjin wound.
Radix Astragali, have benefiting qi and raising yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, the function of promoting pus discharge and tissue regeneration, cure mainly all Qi and blood deficiencies it
Card, such as splenasthenic diarrhea, cough due to deficiency of the lung, rectal prolapse, metroptosis, spontaneous perspiration, night sweat, oedema, blood-arthralgia, ulcer is difficult to burst or burst for a long time and does not holds back.
The effect of pappy shell has puckery intestines of astringing the lung, reinforces the kidney, analgesic, is used for chronic cough due to asthenia of viscera, pants, diarrhea, dysentery, rectal prolapse,
Seminal emission, leukorrhea, trusted subordinate and arthralgia and myalgia.
Cuttle bone has the effects that relieving haperacidity analgesic, hemostasis, synthetism, bone defect healing, radioresistance, antitumor, antiulcer.
Red halloysite, silicates mineral halloysite race halloysite are main to contain four water alumina silicate (Al4(Si4O10)
(OH)8·4H2O), there is relieving diarrhea with astringent, hemostasis；The effect of hygroscopic sore, for rushing down protracted dysentery, rectal prolapse is had blood in stool, uterine bleeding, under band,
Seminal emission, sore burst for a long time and does not holds back, eczema, traumatic hemorrhage.
Longan seed has the function of promoting the circulation of qi dissipating bind, hemostasis, eliminating dampness.
The effect of myrobalan has relieving diarrhea with astringents, astringes the lung to stop cough, fall fire relieving sore-throat.
Corydalis tuber has promoting blood circulation to remove blood stasis, the effect of promoting qi circulation and relieving pain, is used for chest impediment and cardialgia, epigastric pain, pain in the back, hernia pain,
Dysmenorrhoea, Amenorrhea, postpartum stasis of blood, traumatic injury.
Nutmeg has the effect of middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents.It is usually used in deficiency-cold in spleen and stomach, endless diarrhea, abdominal distention,
Deficiency of food is vomitted.
The shell of areca nut, have promoting the circulation of qi it is wide in, line water detumescence, retention of damp leading to blockage of QI, it is bored that gastral cavity abdomen is swollen, defecate not well, oedema turgor, tinea pedis
Edema, difficult urination.
Fructus Aurantii has the effect of regulating the flow of QI to ease the stomach, row stagnant dissipate-swelling.It is usually used in the chest side of body stagnation of the circulation of vital energy, turgor pain, accumulation of food in the stomach and intes tine due to indigestion, phlegm
Stop in drink, visceral organ ptosis.
The effect of seed of Oriental arborvitae has mental-tranquilization, relaxes bowel, hidroschesis.For deficiency of YIN-blood, dysphoria insomnia, palpitaition is seized with terror
It is sad, dry constipation of intestines, night sweat due to yin deficiency.
The present invention is with ginseng, Radix Astragali, pappy shell, cuttle bone, longan seed, myrobalan, corydalis tuber, nutmeg, the shell of areca nut, trifoliate orange
Shell, the seed of Oriental arborvitae by the compatibility of science, can lead in relieving diarrhea with astringents, relieving spasm to stop pain, strengthening exterior and reducing sweat, wet spleen antidiarrheal, tune it is stagnant, promote the production of body fluid only
Yearningly, Shengyang Zhixie, promoting qi circulation and relieving pain, solution of calming the nerves are strongly fragrant, act synergistically between each ingredient, fundamentally solve acute chronic enteritis, colitis
Pathogenic factor directly removes lesion, achievees the purpose that radical cure.By adjusting effective in different pH value extraction bulk pharmaceutical chemicals in the present invention
Ingredient can improve the recovery rate of active ingredient, meanwhile, after extracting solution neutralizes twice, generating portion calcium acetate can improve medicine
The medical value of object.
Advantages of the present invention is：
（1）The present invention can fundamentally solve acute chronic enteritis, colitis, intestines work(by each raw material of compatibility of science
The disorderly pathogenic factor of energy, directly removes lesion, achievees the purpose that radical cure.
（2）Drug provided by the invention is small to stomach burden, and safe and efficient, utilization ratio of drug is high and easy to use.
Specific implementation mode
With reference to specific embodiment, the present invention is described in further detail, it should be appreciated that, following the description
Merely to explaining the present invention, its content is not limited.It is parts by weight if following composition is without specified otherwise.
Embodiment 1
A kind of capsule for treating acute chronic enteritis, colitis, bowel dysfunction, the capsule are to pass through following weight parts
Bulk pharmaceutical chemicals are made：40 parts of ginseng, 45 parts of pappy shell, 15 parts of cuttle bone, 100 parts of red halloysite, 60 parts of longan seed, is scolded at 110 parts of Radix Astragali
60 parts of son, 65 parts of corydalis tuber, 100 parts of nutmeg, 30 parts of the shell of areca nut, 30 parts of Fructus Aurantii, 30 parts of the seed of Oriental arborvitae.
The preparation method of the capsule is：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into 100 mesh fine powders, it is spare；
（2）The aqueous acetic acid that 10 times of pH values are 4.5 will be added in the surplus stock medicine of parts by weight, extracts 2 hours, mistake
Filter；
（3）The calcium hydroxide aqueous solution that 10 times of pH values are 8.5 will be added in filtered filter residue, extracts 2 hours, filtering；
（4）Above-mentioned filtered filtrate twice is merged, it is that be concentrated into relative density after neutrality be 1.20 to adjust pH value
Thick paste gets dry extract after dry；
（5）Step will be added in dry cream（1）Middle fine powder granulation, it is dry, 0.5% magnesium stearate is added, mixing is filled, system
At the capsule of every weight 0.4g.
Embodiment 2
A kind of tablet for treating acute chronic enteritis, colitis, bowel dysfunction, the tablet are by following weight parts raw material
Medicine is made：60 parts of ginseng, 120 parts of Radix Astragali, 60 parts of pappy shell, 10 parts of cuttle bone, 80 parts of red halloysite, 80 parts of longan seed, myrobalan 85
Part, 80 parts of corydalis tuber, 130 parts of nutmeg, 25 parts of the shell of areca nut, 40 parts of Fructus Aurantii, 25 parts of the seed of Oriental arborvitae.
The preparation method of the tablet is：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into 100 mesh fine powders, it is spare；
（2）The aqueous acetic acid that 8 times of pH values are 5.5 will be added in the surplus stock medicine of parts by weight, extracts 2 hours, filtering；
（3）The calcium hydroxide aqueous solution that 8 times of pH values are 8.0 will be added in filtered filter residue, extracts 2 hours, filtering；
（4）Above-mentioned filtered filtrate twice is merged, it is that be concentrated into relative density after neutrality be 1.05 to adjust pH value
Thick paste gets dry extract after dry；
（5）Step will be added in dry cream（1）Middle fine powder granulation, it is dry, 0.5% magnesium stearate, mixing, tabletting, system is added
At the tablet of every weight 0.4g.
Embodiment 3
A kind of pill for treating acute chronic enteritis, colitis, bowel dysfunction, the pill are by following weight parts raw material
Medicine is made：20 parts of ginseng, 80 parts of Radix Astragali, 20 parts of pappy shell, 13 parts of cuttle bone, 120 parts of red halloysite, 40 parts of longan seed, myrobalan 100
Part, 40 parts of corydalis tuber, 70 parts of nutmeg, 20 parts of the shell of areca nut, 35 parts of Fructus Aurantii, 20 parts of the seed of Oriental arborvitae.
The preparation method of the pill is：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into 100 mesh fine powders, it is spare；
（2）The aqueous acetic acid that 14 times of pH values are 5.5 will be added in surplus stock medicine, extracts 2 hours, filtering；
（3）The calcium hydroxide aqueous solution that 14 times of pH values are 8.0 will be added in filtered filter residue, extracts 2 hours, filtering；
（4）Above-mentioned filtered filtrate twice is merged, it is that be concentrated into relative density after neutrality be 1.05 to adjust pH value
Thick paste gets dry extract after dry；
（5）Step will be added in dry cream（1）The weight 0.2g per ball is made in middle fine powder and appropriate pharmaceutic adjuvant, mixing, general ball
Pill.
Embodiment 4
A kind of capsule for treating acute chronic enteritis, colitis, bowel dysfunction, the capsule are to pass through following weight parts
Bulk pharmaceutical chemicals are made：40 parts of ginseng, 45 parts of pappy shell, 15 parts of cuttle bone, 100 parts of red halloysite, 60 parts of longan seed, is scolded at 110 parts of Radix Astragali
60 parts of son, 65 parts of corydalis tuber, 100 parts of nutmeg, 30 parts of the shell of areca nut, it is 30 parts of Fructus Aurantii, 30 parts of the seed of Oriental arborvitae, 85 parts of Chinese actinidia root, windproof
50 parts, 60 parts of Cortex Magnoliae Officinalis, 25 parts of fructus amomi.
That the preparation method is the same as that of Example 1 is identical for the capsule, Chinese actinidia root, windproof, Cortex Magnoliae Officinalis, fructus amomi be added in extraction components into
Row extraction.
Embodiment 5
A kind of capsule for treating acute chronic enteritis, colitis, bowel dysfunction, the capsule are to pass through following weight parts
Bulk pharmaceutical chemicals are made：40 parts of ginseng, 45 parts of pappy shell, 15 parts of cuttle bone, 100 parts of red halloysite, 60 parts of longan seed, is scolded at 110 parts of Radix Astragali
60 parts of son, 65 parts of corydalis tuber, 100 parts of nutmeg, 30 parts of the shell of areca nut, 30 parts of Fructus Aurantii, 30 parts of the seed of Oriental arborvitae, 100 parts of rhizoma alismatis, Radix Codonopsis 90
Part, 85 parts of Rhizoma Atractylodis Macrocephalae, 80 parts of granatum.
The preparation method is the same as that of Example 1 for the capsule, and it is 100 mesh fine powders that the same ginseng of Radix Codonopsis, cuttle bone, the seed of Oriental arborvitae, which crush,
Other surplus stock medicines extract.
Embodiment 6
A kind of tablet for treating acute chronic enteritis, colitis, bowel dysfunction, the tablet are by following weight parts raw material
Medicine is made：60 parts of ginseng, 120 parts of Radix Astragali, 60 parts of pappy shell, 10 parts of cuttle bone, 100 parts of red halloysite, 80 parts of longan seed, myrobalan 85
Part, 80 parts of corydalis tuber, 130 parts of nutmeg, 25 parts of the shell of areca nut, 40 parts of Fructus Aurantii, 25 parts of the seed of Oriental arborvitae, 100 parts of Chinese cassia tree, Schisandra chinensis 86
Part, 75 parts of the membrane of a chicken's gizzard.
The preparation method of the tablet is identical with embodiment 2, and Chinese cassia tree, Schisandra chinensis and the membrane of a chicken's gizzard are added in extraction components and carry out
Extraction.
Embodiment 7
A kind of capsule for treating acute chronic enteritis, colitis, bowel dysfunction, the capsule are to pass through following weight parts
Bulk pharmaceutical chemicals are made：20 parts of ginseng, 20 parts of pappy shell, 13 parts of cuttle bone, 100 parts of red halloysite, 40 parts of longan seed, is scolded at 80 parts of Radix Astragali
100 parts of son, 40 parts of corydalis tuber, 70 parts of nutmeg, 20 parts of the shell of areca nut, it is 35 parts of Fructus Aurantii, 20 parts of the seed of Oriental arborvitae, 85 parts of Chinese actinidia root, windproof
50 parts, 60 parts of Cortex Magnoliae Officinalis, 25 parts of fructus amomi, 100 parts of Chinese cassia tree, 86 parts of Schisandra chinensis, 75 parts of the membrane of a chicken's gizzard.
The capsule the preparation method is the same as that of Example 1 identical, Chinese actinidia root, windproof, Cortex Magnoliae Officinalis, fructus amomi, Chinese cassia tree, Schisandra chinensis, chicken
Interior gold is added in extraction bulk pharmaceutical chemicals and extracts.
Embodiment 8
A kind of pill for treating acute chronic enteritis, colitis, bowel dysfunction, the pill are by following weight parts raw material
Medicine is made：20 parts of ginseng, 80 parts of Radix Astragali, 20 parts of pappy shell, 13 parts of cuttle bone, 90 parts of red halloysite, 40 parts of longan seed, myrobalan 100
Part, 40 parts of corydalis tuber, 70 parts of nutmeg, 20 parts of the shell of areca nut, 35 parts of Fructus Aurantii, 20 parts of the seed of Oriental arborvitae, 85 parts of Chinese actinidia root, it is 50 parts windproof,
60 parts of Cortex Magnoliae Officinalis, 25 parts of fructus amomi, 100 parts of rhizoma alismatis, 90 parts of Radix Codonopsis, 85 parts of Rhizoma Atractylodis Macrocephalae, 80 parts of granatum.
The preparation method of the pill is identical with embodiment 3, and it is that 100 mesh are thin that the same ginseng of Radix Codonopsis, cuttle bone, the seed of Oriental arborvitae, which crush,
Powder, other surplus stock medicines extract.
Comparative example 1
It is a kind of treat acute chronic enteritis, colitis capsule, the bulk pharmaceutical chemicals of the capsule form with embodiment 1.
The preparation method of the capsule：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into 100 mesh fine powders, it is spare；
（2）It will be added in the Radix Astragali of parts by weight, pappy shell, longan seed, myrobalan, corydalis tuber, nutmeg, the shell of areca nut, Fructus Aurantii
10 times of 70% ethyl alcohol extracts twice, 2 hours every time, merging filtrate；
（4）The filtrate of above-mentioned merging is concentrated into the thick paste that relative density is 1.20, is got dry extract after dry；
（5）Step will be added in dry cream（1）Middle fine powder granulation, it is dry, 0.5% magnesium stearate is added, mixing is filled, system
At the capsule of every weight 0.4g.
Toxicity test：
Test method：It takes SD rats 80,180~220g of weight, half male and half female that rat is equally divided into 8 groups, feeds respectively
Eat the bulk pharmaceutical chemicals combination that 1-8 of the embodiment of the present invention is provided.Drug feeding method is：Above-mentioned raw materials of the present invention are smashed, are used
Water is made into suspension.Gavage drug suspension, daily rat dosage are 1.5g/Kg, Rat Fast to every group of rat three times a day
It can't help water, like this method continuous gavage 15 days.
As a result：During rat medication, for rat without poisoning, the phenomena of mortality, each group activities in rats, appetite are normal.Through solution
Kidney, liver, adrenal cortex, genitals are cutd open to have no significant change.
Conclusion：It can be seen from the results above that medication amount used in zoopery is much higher by the dose of adult's clinical application,
But rat makes a variation situation without dead or organ, thus can obtain drug of the present invention human body using when have no toxic side effect.
The test of pesticide effectiveness：
Test method：The mouse model 120 for taking inducing colitis, is randomly divided into 3 groups, S1, S2, K1 groups, every group 40
Only, the composition that the S1 group feedings embodiment of the present invention 1 provides, the composition that S2 group feedings comparative example 1 provides, K1 groups are blank pair
According to group.Drug feeding method is：By the particle in capsule, suspension is made into water.Every group of rat gavage drug three times a day
Suspension, daily rat dosage are 1.5g/Kg, and Rat Fast can't help water, like this method continuous gavage 15 days, specific experiment knot
Fruit is shown in Table 1.
Table 1
From table 1 it follows that using composition prepared by preparation method of the present invention, it is high to the cure rate of colitis.
Clinical test
1, case source
640 colitis diseases are chosen, patient all has following symptom：Left lower quadrant pain, diarrhea, it is tenesmus, when just under
Be stained with liquid, defecate uncomfortable, Diarrhoea, when band mucus, with abdominal distension abdominal pain, gastral cavity pain, underbelly falling inflation hangs in the balance, touching
Lower disconnected, recurrent exerbation etc.；Wherein male 374, women 266, the course of disease is most 2 years short, longest 18 years, average course of disease 9 years, patient
Age at 20-60 Sui, average age 30.6 ± 6.5 years old.
2, test method
Patient is randomly divided into 8, every group 80, each group no difference of science of statistics（P ＞ 0.05）, every group of patient is respectively using originally
The drug of inventive embodiments, capsule：One time 3-4（Every 0.4g）Or tablet：3-4 pieces（Every 0.4g）Or pill 6-8g
（0.2g/ balls）, 3 times a day, each group is as a treatment course with 7 days, even served 4 courses for the treatment of, evaluates therapeutic effect.Fasting is pungent during medication
Peppery, fish raw meat food.Pregnant woman uses with caution.Temperaturing injecting-ability Chinese patent drug should not be taken during medication simultaneously.
3, efficacy assessment standard
Criterion of therapeutical effect reference《New Chinese medicine treats the guideline of clinical investigations of chronic nonspecific ulcerative colitis》
It formulates.It cures：Subjective symptoms disappear or mostly disappear, abdominal pain, diarrhea disappear；Effectively：Symptom is substantially reduced；In vain：Symptom body
Sign is without improvement.Total effective rate=（Cure number of cases+effective number of cases）/ patient number of cases, each group patient's treatment see the table below 2
Table 2
Above-mentioned patient overwhelming majority in treatment shows good effect as can be seen from Table 2, and rapid-action, passes through
This drug further is taken, patient all cures, most short healing time 1 month, longest healing time 4 months, patient's recovery from illness 1
It is paid a return visit without recidivist after year.And during using drug provided by the invention, have no adverse reaction generation, illustrates drug pair of the present invention
Human body has no toxic side effect substantially.
When raw material provided by the invention is prepared into other such as tablets and other formulations, take effect up to 10 a few minutes, and affect
The eating habit of patient, and the course for the treatment of extends.
Model case
Lee, female, 38 years old, with the passing of time, because operating pressure is big, diet is irregular, there is insufficiency of both the spleen and the kindey diarrhea, greatly before 3 years in patient
Just uncomfortable, Diarrhoea, when band mucus, with abdominal distension abdominal pain, gastral cavity pain, underbelly falling inflation, diet is bad.Card is shown in that tongue nature is light
Red, tongue is thin white or greasy, and arteries and veins is subtle or heavy thin, examines as colitis.It using drug of the present invention, fully recovers after 2 months, follow-up has no for 1 year
Recurrence.
Mr. Wang, male, 42 years old, patient was irregular because of diet in the recent period, and it is in water sample, stench, and companion abdominal pain, diarrhea, stool occur
There are cramp, Muscular stiffness.Card is shown in that tongue nature is light red, and tongue is thin white or greasy, and arteries and veins is subtle or heavy thin.It examines as chordapsus.Use this
Invention drug is fully recovered after 2 months, no relapse.
Xing, female, 50 years old, patient was in often discontinuity abdomen secret anguish, with the passing of time anus tenesmus insufficiency of both the spleen and the kindey diarrhea occurs, greatly
Just uncomfortable, Diarrhoea, when band mucus, with abdominal distension abdominal pain, card is shown in lustreless complexion lassitude, and limbs fatigue, happiness temperature is cold,
It examines as chronic enteritis.Using drug of the present invention, fully recover after 2 months, 1 year no relapse of follow-up.
She, man, 38 years old, patient often had abdominal distension, borborygmus and constipation, and defecation is unsmooth, and was busy with one's work or nervous, burnt
When worry, the state of an illness increases, and examines as bowel dysfunction.Using drug of the present invention, fully recover after 4 months, 1 year no relapse of follow-up, spirit
It is in good condition.
Claims (4)
1. a kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction, it is characterised in that：It is by following heavy
The bulk pharmaceutical chemicals of amount proportioning are made：20-60 parts of ginseng, 80-120 parts of Radix Astragali, 20-60 parts of pappy shell, 10-15 parts of cuttle bone, red stone
80-120 parts of fat, 40-80 parts of longan seed, 60-100 parts of myrobalan, 40-80 parts of corydalis tuber, 70-130 parts of nutmeg, shell of areca nut 20-
30 parts, 30-40 parts of Fructus Aurantii, 20-30 parts of the seed of Oriental arborvitae；
Specific preparation method is as follows：
（1）Ginseng, cuttle bone, the seed of Oriental arborvitae are ground into fine powder, it is spare；
（2）The aqueous acetic acid that 8-14 times of pH value is 4.5-5.5 will be added in the remaining bulk pharmaceutical chemicals of parts by weight, extracts 2 hours,
Filtering；
（3）The calcium hydroxide aqueous solution that 8-14 times of pH value is 8.0-8.5 will be added in filtered filter residue, extracts 2 hours, mistake
Filter；
（4）Above-mentioned filtered filtrate twice is merged, it is that be concentrated into relative density after neutrality be 1.05-1.20's to adjust pH value
Thick paste gets dry extract after dry；
（5）Step will be added in dry cream（1）Middle fine powder is to get the Chinese medicine composition.
2. Chinese medicine composition according to claim 1, which is characterized in that the bulk pharmaceutical chemicals are：40 parts of ginseng, Radix Astragali 110
Part, 45 parts of pappy shell, 15 parts of cuttle bone, 100 parts of red halloysite, 60 parts of longan seed, 60 parts of myrobalan, 65 parts of corydalis tuber, nutmeg 100
Part, 30 parts of the shell of areca nut, 30 parts of Fructus Aurantii, 30 parts of the seed of Oriental arborvitae.
3. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition further includes synergy raw material
Medicine, the synergy bulk pharmaceutical chemicals are one or more groups of in following three groups：
First group：85 parts of Chinese actinidia root, 50 parts windproof, 60 parts of Cortex Magnoliae Officinalis, 25 parts of fructus amomi；
Second group：100 parts of rhizoma alismatis, 90 parts of Radix Codonopsis, 85 parts of Rhizoma Atractylodis Macrocephalae, 80 parts of granatum；
Third group：100 parts of Chinese cassia tree, 86 parts of Schisandra chinensis, 75 parts of the membrane of a chicken's gizzard.
4. according to claim 1-3 any one of them Chinese medicine compositions, it is characterised in that：The dosage form of the Chinese medicine composition is
Capsule, tablet or pill.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510120414.2A CN104666702B (en) | 2015-03-19 | 2015-03-19 | A kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction |
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| CN201510120414.2A CN104666702B (en) | 2015-03-19 | 2015-03-19 | A kind of Chinese medicine composition for treating acute chronic enteritis, colitis, bowel dysfunction |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101112553A (en) * | 2007-08-17 | 2008-01-30 | 孙元萍 | Oral Chinese traditional medicine composition for treating chronic enteritis |
| CN101229310A (en) * | 2008-01-14 | 2008-07-30 | 北京中科雍和医药技术有限公司 | Chinese traditional medicine compounds for treating acute and chronic enteritis, colonitis and preparing method thereof |
| CN102697922A (en) * | 2012-03-20 | 2012-10-03 | 章崇芝 | Traditional Chinese medicine composition for treating chronic enteritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112553A (en) * | 2007-08-17 | 2008-01-30 | 孙元萍 | Oral Chinese traditional medicine composition for treating chronic enteritis |
| CN101229310A (en) * | 2008-01-14 | 2008-07-30 | 北京中科雍和医药技术有限公司 | Chinese traditional medicine compounds for treating acute and chronic enteritis, colonitis and preparing method thereof |
| CN102697922A (en) * | 2012-03-20 | 2012-10-03 | 章崇芝 | Traditional Chinese medicine composition for treating chronic enteritis |
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Denomination of invention: Traditional Chinese medicine composition for treating acute and chronic enteritis, colitis and bowel dysfunction Effective date of registration: 20200623 Granted publication date: 20180904 Pledgee: Dongyinghekou sub branch of Agricultural Bank of China Ltd. Pledgor: SHANDONG XIANHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020370010021 |
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