CN107669747A - A kind of compound preparation for treating constipation and preparation method thereof - Google Patents

A kind of compound preparation for treating constipation and preparation method thereof Download PDF

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CN107669747A
CN107669747A CN201711092626.XA CN201711092626A CN107669747A CN 107669747 A CN107669747 A CN 107669747A CN 201711092626 A CN201711092626 A CN 201711092626A CN 107669747 A CN107669747 A CN 107669747A
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compound preparation
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preparation
oligosaccharide
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罗昌兴
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

The invention belongs to pharmaceutical technology field, specifically discloses a kind of compound preparation for treating constipation and preparation method thereof, counts in parts by weight, is made up of following raw material：25 35 parts of Semen Tritici aestivi fiber, 25 30 parts of sorbierite, vitamin B125 35 parts of 0.1 0.5 parts, 25 35 parts of oligosaccharide, 25 30 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome.By the way of the compound preparation of the present invention is combined using Chinese and Western, can not only fast and effectively solve the problems, such as constipation, enteron aisle can also be adjusted, avoid side effect caused by Western medicine and be discontinued repeatedly the problem of, be it is a kind of safely, effectively, have no side effect, the medicine of no dependence.

Description

A kind of compound preparation for treating constipation and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of compound preparation for treating constipation and preparation method thereof.
Background technology
Constipation (constipation) refers to that stool interval is reduced, and times of defecation is less than 2-3 times in one week, or 2-3 days Just defecate 1 time, excrement amount is referred to as constipation when few and dry and hard.But there are a few peoples to be always usually 2-3 talentes stool 1 time, and defecate Character is normal, and such a situation is not considered as constipation；For same people, such as stool is from 1 time a day or every 2 days 1 time is changed into 2 days When above or the longer time begins to defecate 1 time, constipation should be regarded as.Enough attention are must be accorded to constipation patient, are occurred with finding The reason for constipation.
The harm of constipation is summed up, and has 10 broad aspects：1. influence beauty：Constipation patient is detained intestines due to the excrement block length time Road, abnormal fermentation, largely harmful toxin can be produced after corrupt, easily raw acne, facial pigmentation, fash etc..2. cause fertilizer It is fat：Toxin causes large intestine oedema, and lower part of the body blood circulation slows down, and easily forms pyriform stature and fat belly.3. produce body odor：Toxin Aggregation can cause halitosis and body odor.4. distaste for food：Constipation can make belly turgor, produce nausea, apocleisis, food and it is tasteless.⑤ Neurasthenia：Constipation patient can have the symptoms such as irritated, confused and worried, insomnia.6. trigger dysmenorrhoea：Chronic constipation patient is due to long-term Pelvic muscle stimulates, and can often trigger dysmenorrhoea.7. sexual hypoesthesia：Prolonged constipation patient can have sexual hypoesthesia.8. complication：Constipation Patient can concurrently anal intestine disease, such as hemorrhoid, anal fissure, the prolapse of rectum.In addition, also it is susceptible to suffer from the anaphylactias such as nettle rash, asthma.⑨ Induce cancer：Harmful toxins persistently stimulate intestinal mucosa, are easily caused colorectal cancer, still induce breast cancer in addition.10. cause to die suddenly：It is special It is not the cardiovascular patients such as hypertension, coronary heart disease, difficult defecation can steeply rise blood pressure, cause apoplexy or even die suddenly.
At present, the medicine (including Western medicine and Chinese medicine) for clinically constantly having the new habitual intractable constipation for the treatment of occurs, But these fail to reach real gratifying effect.The Chinese and Western medicine compound drug for develop a kind of high-efficiency low-toxicity, treating both principal and secondary aspect of disease It is still clinical eager needs.
The content of the invention
In order to solve the above problems, the present invention provides a kind of compound preparation for treating constipation and preparation method thereof, this preparation With reference to Chinese and western medical theory, rational proportion, the compound preparation that the present invention treats constipation is formed, while effectively treatment constipation The problem of overcoming the side effect of Western medicine, being discontinued repeatedly, reaches the purpose treated both principal and secondary aspect of disease.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of compound preparation for treating constipation, by weight Number meter, is made up of following raw material：Semen Tritici aestivi fiber 25-35 parts, sorbierite 25-30 parts, vitamin B10.1-0.5 parts, oligosaccharide 25- 35 parts, capsule of weeping forsythia 25-30 parts and bighead atractylodes rhizome 25-35 parts.
On the basis of above-mentioned technical proposal, the present invention can also do following improvement.
Preferably, a kind of compound preparation for treating constipation, is counted in parts by weight, is made up of following raw material：Semen Tritici aestivi fiber 25 Part, 30 parts of sorbierite, vitamin B135 parts of 0.1 part, 35 parts of oligosaccharide, 25 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome.
Preferably, a kind of compound preparation for treating constipation, is counted in parts by weight, is made up of following raw material：Semen Tritici aestivi fiber 35 Part, 30 parts of sorbierite, vitamin B125 parts of 0.5 part, 25 parts of oligosaccharide, 25 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome.
Preferably, a kind of compound preparation for treating constipation, is counted in parts by weight, is made up of following raw material：Semen Tritici aestivi fiber 30 Part, 25 parts of sorbierite, vitamin B130 parts of 0.3 part, 30 parts of oligosaccharide, 30 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome.
Preferably, a kind of compound preparation for treating constipation, described oligosaccharide are selected from FOS, galactooligosaccharide, low One or more of combinations in xylan, inulin.
The present invention also provides a kind of preparation method for the compound preparation for treating constipation, comprises the following steps：
Step 1：Take Semen Tritici aestivi fiber 25-35 parts, sorbierite 25-30 parts, vitamin B10.1-0.5 parts, oligosaccharide 25-35 Part, capsule of weeping forsythia 25-30 parts and bighead atractylodes rhizome 25-35 parts；
Step 2：The capsule of weeping forsythia, the bighead atractylodes rhizome add to the water of 3 times of parts by weight, decocts 1-2 hours, filtering, by the dregs of a decoction plus 2 times of quality Water, decoct 30 minutes, merge filtrate, and it is 20-25% that the filtrate after merging, which is dried to water content, obtains extract twice；
Step 3：By vitamin B1Crushed respectively with FOS and cross 80 mesh sieves；
Step 4：Sorbierite is configured to 35wt% sorbitol solution；
Step 5：FOS after Semen Tritici aestivi fiber is handled with step 3 is stirred, and is added with the method for equal increments The vitamin B1 handled through step 3, continues to stir 10-15 minutes, then adds sorbitol aqueous solution and step that step 4 obtains 2 extracts obtained, continue stirring 5 minutes, obtain softwood, are dried after granulation.
Preferably, a kind of preparation method for the compound preparation for treating constipation, granulation described in step 5 is to be put into softwood to wave The particle of 12 mesh is made in granulator.
Preferably, a kind of preparation method for the compound preparation for treating constipation, drying described in step 5 are that the particle that will be made is put It is total to enter vacuum drying chamber, is dried 2 hours under conditions of 75-80 DEG C.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention combines Chinese and western medical theory, and selection function medicine carries out rational proportion, and present invention treatment constipation is made Compound preparation.By the way of the compound preparation of the present invention is combined using Chinese and Western, can not only fast and effectively solve asking for constipation Topic, additionally it is possible to enteron aisle is adjusted, the problem of avoiding side effect caused by Western medicine and be discontinued repeatedly, be it is a kind of safely, have Imitate, have no side effect, the medicine of no dependence.
Embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit Determine the scope of the present invention.
Embodiment 1
A kind of preparation for the compound preparation for treating constipation, comprises the following steps：
Step 1：Take Semen Tritici aestivi fiber 25g, sorbierite 30g, vitamin B10.1g, oligosaccharide 35g, capsule of weeping forsythia 25g and the bighead atractylodes rhizome 35g；
Step 2：The capsule of weeping forsythia, the bighead atractylodes rhizome add to the water of 3 times of parts by weight, decocts 1.5 hours, filtering, by the dregs of a decoction plus 2 times of quality Water, decoct 30 minutes, merge filtrate, and it is 20-25% that the filtrate after merging, which is dried to water content, obtains extract twice；
Step 3：By vitamin B1Crushed respectively with FOS and cross 80 mesh sieves；
Step 4：Sorbierite is configured to 35wt% sorbitol solution；
Step 5：FOS after Semen Tritici aestivi fiber is handled with step 3 is stirred, and is added with the method for equal increments The vitamin B1 handled through step 3, continue stirring 15 minutes, the sorbitol aqueous solution and step 2 for then adding step 4 acquisition obtain The extract obtained, continue stirring 5 minutes, obtain softwood, dried after granulation.
Embodiment 2
A kind of preparation for the compound preparation for treating constipation, comprises the following steps：
Step 1：Take Semen Tritici aestivi fiber 35g, sorbierite 30g, vitamin B10.5g, oligosaccharide 25g, capsule of weeping forsythia 25g and the bighead atractylodes rhizome 25g；
Step 2：The capsule of weeping forsythia, the bighead atractylodes rhizome add to the water of 3 times of parts by weight, decocts 2 hours, filtering, by the dregs of a decoction plus the water of 2 times of quality, Decoct 30 minutes, merge filtrate, and it is 20-25% that the filtrate after merging, which is dried to water content, obtains extract twice；
Step 3：By vitamin B1Crushed respectively with FOS and cross 80 mesh sieves；
Step 4：Sorbierite is configured to 35wt% sorbitol solution；
Step 5：FOS after Semen Tritici aestivi fiber is handled with step 3 is stirred, and is added with the method for equal increments The vitamin B1 handled through step 3, continue stirring 10 minutes, the sorbitol aqueous solution and step 2 for then adding step 4 acquisition obtain The extract obtained, continue stirring 5 minutes, obtain softwood, dried after granulation.
Embodiment 3
A kind of preparation for the compound preparation for treating constipation, comprises the following steps：
Step 1：Take Semen Tritici aestivi fiber 30g, sorbierite 25g, vitamin B10.3g, oligosaccharide 30g, capsule of weeping forsythia 30g and the bighead atractylodes rhizome 30g；
Step 2：The capsule of weeping forsythia, the bighead atractylodes rhizome add to the water of 3 times of parts by weight, decocts 1 hour, filtering, by the dregs of a decoction plus the water of 2 times of quality, Decoct 30 minutes, merge filtrate, and it is 20-25% that the filtrate after merging, which is dried to water content, obtains extract twice；
Step 3：By vitamin B1Crushed respectively with FOS and cross 80 mesh sieves；
Step 4：Sorbierite is configured to 35wt% sorbitol solution；
Step 5：FOS after Semen Tritici aestivi fiber is handled with step 3 is stirred, and is added with the method for equal increments The vitamin B1 handled through step 3, continue stirring 12 minutes, the sorbitol aqueous solution and step 2 for then adding step 4 acquisition obtain The extract obtained, continue stirring 5 minutes, obtain softwood, dried after granulation.
The medicine that above-described embodiment 1 is prepared to the treatment constipation of gained carries out pharmacological experiment：
1st, acute toxicity testing
With the drug study of the obtained treatment constipation of the embodiment of the present invention 1, by the way of gastric infusion, in 24 hours Twice, every minor tick 8 hours, 1.5g/kg is administered in successive administration every time, daily accumulative administration 3g/kg, equivalent to people's clinical application 50 times.In administration 7 days, the activity of mouse, feed, normal, the well-grown of excretion, hair color light.As a result show：The present invention The medicine of constipation is treated without acute toxic reaction.
2nd, long term toxicity test
With the drug study of the obtained treatment constipation of the embodiment of the present invention 1, by the way of gastric infusion, successive administration 24 In week, twice daily, 1.5g/kg is administered every time, daily accumulative administration 3g/kg, equivalent to 50 times of people's clinical application.After 24 weeks, Physiochemical indice, the blood parameters of mouse have no significant effect, and Systematic anatomy, organ coefficient and histopathological examination are not yet Noted abnormalities pathological change, and obvious change is also had no after being discontinued two weeks.As a result show, the medicine of present invention treatment constipation is non-toxic Reaction, long-term prescription are safe and reliable.
3rd, clinical test
160 constipation patients, wherein male patient 89 are randomly selected, female patient 71 is age 22-65 year, average 42.3 years old age, course of disease 1-5.Symptom：Defecation time extends, and three days with last time, excrement dry, hard.Take of the invention real Apply the preparation of example 1 treatment constipation and medicine one week, once a day, each 1.5g, wherein there are 90 patients to cure, guarantee two days Once, just matter turns profit to defecation, unobstructed during solution, in short term without recurrence；42 conditions of patients take a turn for the better, and once, just matter turns defecation in three days Profit, but defecation owes smooth.The effective percentage of the medicine for the treatment of constipation manufactured in the present embodiment is up to 82.5%.

Claims (8)

1. a kind of compound preparation for treating constipation, it is characterised in that count, be made up of following raw material in parts by weight：Semen Tritici aestivi fiber 25-35 parts, sorbierite 25-30 parts, vitamin B10.1-0.5 parts, oligosaccharide 25-35 parts, capsule of weeping forsythia 25-30 parts and bighead atractylodes rhizome 25-35 Part.
A kind of 2. compound preparation for treating constipation according to claim 1, it is characterised in that count in parts by weight, by with Lower raw material composition：25 parts of Semen Tritici aestivi fiber, 30 parts of sorbierite, vitamin B10.1 part, 35 parts of oligosaccharide, 25 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome 35 Part.
A kind of 3. compound preparation for treating constipation according to claim 1, it is characterised in that count in parts by weight, by with Lower raw material composition：35 parts of Semen Tritici aestivi fiber, 30 parts of sorbierite, vitamin B10.5 part, 25 parts of oligosaccharide, 25 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome 25 Part.
A kind of 4. compound preparation for treating constipation according to claim 1, it is characterised in that count in parts by weight, by with Lower raw material composition：30 parts of Semen Tritici aestivi fiber, 25 parts of sorbierite, vitamin B10.3 part, 30 parts of oligosaccharide, 30 parts of the capsule of weeping forsythia and the bighead atractylodes rhizome 30 Part.
5. a kind of compound preparation for treating constipation according to claim 1, it is characterised in that described oligosaccharide is selected from low One or more of combinations in Fructooligosaccharides, galactooligosaccharide, xylo-oligosaccharide, inulin.
6. a kind of preparation method for the compound preparation for treating constipation, it is characterised in that comprise the following steps：
Step 1：Take Semen Tritici aestivi fiber 25-35 parts, sorbierite 25-30 parts, vitamin B10.1-0.5 parts, oligosaccharide 25-35 parts, the capsule of weeping forsythia 25-30 parts and bighead atractylodes rhizome 25-35 parts；
Step 2：The capsule of weeping forsythia, the bighead atractylodes rhizome are added to the water of 3 times of parts by weight, decocted 1-2 hours, filtering, the dregs of a decoction plus the water of 2 times of quality are decocted Boil 30 minutes, merge filtrate, and it is 20-25% that the filtrate after merging, which is dried to water content, obtains extract twice；
Step 3：By vitamin B1Crushed respectively with FOS and cross 80 mesh sieves；
Step 4：Sorbierite is configured to 35wt% sorbitol solution；
Step 5：FOS after Semen Tritici aestivi fiber is handled with step 3 is stirred, and is added with the method for equal increments through step The vitamin B1 of rapid 3 processing, continues to stir 10-15 minutes, and the sorbitol aqueous solution and step 2 for then adding step 4 acquisition obtain The extract obtained, continue stirring 5 minutes, obtain softwood, dried after granulation.
A kind of 7. preparation method of compound preparation for treating constipation according to claim 6, it is characterised in that step 5 institute It is that softwood is put into the particle that 12 mesh are made in oscillating granulator to state granulation.
A kind of 8. preparation method of compound preparation for treating constipation according to claim 6, it is characterised in that step 5 institute Stating drying, to be that the particle that will be made is put into vacuum drying chamber total, is dried 2 hours under conditions of 75-80 DEG C.
CN201711092626.XA 2017-11-08 2017-11-08 A kind of compound preparation for treating constipation and preparation method thereof Withdrawn CN107669747A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112386577A (en) * 2019-08-16 2021-02-23 北京天衡药物研究院有限公司 Composition for treating constipation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112386577A (en) * 2019-08-16 2021-02-23 北京天衡药物研究院有限公司 Composition for treating constipation
CN112386577B (en) * 2019-08-16 2024-01-23 北京天衡药物研究院有限公司 Composition for treating constipation

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