CN104225105B - For treating the pharmaceutical preparation of trigeminal neuralgia - Google Patents

Abstract

The present invention provides a kind of for treating the pharmaceutical preparation of trigeminal neuralgia, bulk pharmaceutical chemicals include the vine of multiflower knotweed, Selaginella tamariscina, myrrh, fructus viticis, Rhizoma Chuanxiong, oyster, earthworm, windproof, wilsonii, pyrola, Radix Glycyrrhizae, the root of Dahurain angelica, schizonepeta, the dried immature fruit of citron orange, Conyza japonica, wooden indigo plant, salvia chinensis, Cortex Magnoliae Officinalis, the Bi roots of grass, Japanese cryptotaenia stem and leaf and west safflower.The pharmaceutical preparation has significant effect to the treatment of trigeminal neuralgia, and has no toxic side effect, cheap.

Description

For treating the pharmaceutical preparation of trigeminal neuralgia

Technical field

The present invention relates to technical field of Chinese medicine more particularly to a kind of pharmaceutical preparations for being used to treat trigeminal neuralgia.

Background technology

Trigeminal neuralgia is oral surgery field clinic the most common type neuropathy, is a kind of common painful disease Disease, patient is in the majority with middle-aged and elderly people, is often accompanied by various chronic diseases, and the treatment for making this sick is subject to certain restrictions, the disease 50 years old or more patient is more common in, women is high compared with male's incidence.

The disease is the of short duration severe pain of paroxysmal after occurring repeatedly in trigeminal neuralgia branch range.It is often accompanied by ipsilateral muscle The neurapraxias such as twitch, insentience shortage.

Modern medicine thinks that trigeminal neuralgia is a kind of demyelinating disease, and some scholars are considered a kind of epilepsia thalamica sample Breaking-out, providing position may be in nucleus tractus spinalis nervi trigemini, and Antiepileptic Drugs are effective.The disease is existing century-old to the greatest extent to be gone through History, but etiology unknown is true so far, and this just brings extreme difficulties to treatment.For many years, many scholars inquire into various methods, including With the conservative treatment of drug blockage, operation of opening cranium, radio frequency heat cure, Jawbone Pathoses bone cavity scaling, evulsion of trigeminal nerve art etc. All multi-methods, all because of high recurrence rate, efficient low and dangerous height, the reasons such as operating difficulty is big, and complication is more, it is impossible to be allowed to Wide popularization and application.

The trigeminal neuralgia category traditional Chinese medical science " intermittent headache ", " blurred vision ", the scope of " prosopodynia ", it is believed that its etiology and pathogenesis be wind, fire, Cold, phlegm, the stasis of blood, void, making three yang channel muscle, amenorrhoea network is stopped up, qi and blood stagnation causes pain to occur suddenly, due to wind in upper criminal mountain peak top by heresy Its evil property of fire is apt to, and migration is indefinite, when as when stop, lightning sample breaking-out.Or emotional discomfort, stagnation of liver qi, it is strongly fragrant and change fire so that Hematogenous blockage, the train of thought stasis of blood, the moon that is heavy then robbing impariment of the liver kidney, hyperactivity of yang due to yin deficiency above disturbs clear key, and triggers this disease.

Traditional Chinese medicine thinks, the gas of the clear sun of six internal organs, the blood of the five internal organs elite is all compiled in head, oneself does not enter person's wind outside, fire follow through heresy, It all can be that pain or cover covers its clear sun or stasis of blood plug its channels and collaterals from interior originator gas, blood, phlegm, strongly fragrant obstruction, therefore fight with positive gas phase, it is evil Poly- then arteries and veins is expired, and arteries and veins is also full if perverse trend is delaied, and disorderly event is long bitterly for vim and vigour.Migraine always belongs to the moon of fainting, yin, yang is bright less, gastrointestine dryness heat, Liver and gall wind fire, three through heresy stop up amenorrhoea network, then severe pain breaks out, its property of the heresy of wind fire is moved, thus when stop when sending out.

Therefore, in the treatment using replenishing and activating blood, dispelling wind and removing obstruction in the meridians, promoting blood circulation and stopping pain as principle, the present invention is managed with the Chinese traditional treatment It is a kind of for treating the pharmaceutical preparation of trigeminal neuralgia by for principle, providing, have to the treatment of trigeminal neuralgia significant Effect, and have no toxic side effect, it is cheap.

The content of the invention

The technical problems to be solved by the invention are to provide a kind of pharmaceutical preparation for being used to treat trigeminal neuralgia, to three Pitching neuralgic treatment has significant effect, and has no toxic side effect, cheap.

In order to solve the above technical problems, the present invention provides a kind of for treating the pharmaceutical preparation of trigeminal neuralgia, it is former Expect medicine include the vine of multiflower knotweed, Selaginella tamariscina, myrrh, fructus viticis, Rhizoma Chuanxiong, oyster, earthworm, windproof, wilsonii, pyrola, Radix Glycyrrhizae, the root of Dahurain angelica, Schizonepeta, the dried immature fruit of citron orange, Conyza japonica, wooden indigo plant, salvia chinensis, Cortex Magnoliae Officinalis, the Bi roots of grass, Japanese cryptotaenia stem and leaf and west safflower.

Wherein, the weight of each bulk pharmaceutical chemicals is respectively vine of multiflower knotweed 35g~45g, Selaginella tamariscina 25g~35g, does not have in the pharmaceutical preparation Medicine 30g~40g, fructus viticis 20g~30g, Rhizoma Chuanxiong 35g~45g, oyster 25g~35g, earthworm 15g~25g, windproof 20g~ 30g, wilsonii 35g~45g, pyrola 15g~25g, Radix Glycyrrhizae 20g~30g, root of Dahurain angelica 25g~35g, schizonepeta 20g~30g, the dried immature fruit of citron orange 15g~25g, Conyza japonica 15g~25g, wooden indigo plant 20g~30g, salvia chinensis 15g~25g, Cortex Magnoliae Officinalis 15g~25g, Bi roots of grass 25g~ 35g, Japanese cryptotaenia stem and leaf 20g~30g and west safflower 35g~45g.

Wherein, the weight of each bulk pharmaceutical chemicals is respectively vine of multiflower knotweed 40g~45g, Selaginella tamariscina 30g~35g, does not have in the pharmaceutical preparation Medicine 35g~40g, fructus viticis 25g~30g, Rhizoma Chuanxiong 40g~45g, oyster 30g~35g, earthworm 20g~25g, windproof 25g~ 30g, wilsonii 40g~45g, pyrola 20g~25g, Radix Glycyrrhizae 20g~25g, root of Dahurain angelica 25g~30g, schizonepeta 20g~25g, the dried immature fruit of citron orange 15g~20g, Conyza japonica 15g~20g, wooden indigo plant 20g~25g, salvia chinensis 15g~20g, Cortex Magnoliae Officinalis 15g~20g, Bi roots of grass 25g~ 30g, Japanese cryptotaenia stem and leaf 20g~25g and west safflower 35g~40g.

Wherein, the weight of each bulk pharmaceutical chemicals is respectively vine of multiflower knotweed 40g, Selaginella tamariscina 30g, myrrh 35g, wild pepper in the pharmaceutical preparation Sub- 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, chaste tree Mustard 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, salvia chinensis 20g, Cortex Magnoliae Officinalis 20g, Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower 40g。

Wherein, the dosage form of the pharmaceutical preparation is decoction liquor or oral liquid.

The present invention also provides the preparation method of said medicine preparation, when the dosage form of the pharmaceutical preparation is decoction liquor, Specially：

Each bulk pharmaceutical chemicals component is crushed respectively, is mixed, mixture is obtained, adds water to cook 2 times, is added for the first time Enter the water compared with 3~5 times of quality of mixture quality, when decoction 1~2 is small, filtering is added in again in filter residue compared with mixing The water of 2~4 times of quality of amount of substance, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure, and obtains Crude drug concentration is the solution of 1g/ml.

The present invention also provides the preparation method of said medicine preparation, when the dosage form of the pharmaceutical preparation is oral liquid, Specially：

Each bulk pharmaceutical chemicals component is crushed, mixed by the first step respectively, is obtained mixture, is added water to cook 2 times, The water compared with 3~5 times of quality of mixture quality is added in for the first time, and when decoction 1~2 is small, filtering adds in phase again in filter residue For the water of 2~4 times of quality of mixture quality, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, decompression Concentration obtains dry cream, is ground into powder；

Second step takes 500g powder, adds in 500ml distillation water dissolutions, then adds in sucrose 50g, ethylparaben 5g is stirred It mixes and is uniformly dissolved, stood under conditions of 0 DEG C~4 DEG C for 24 hours, filtering through ultraviolet ray sterilization bactericidal, is distributed into bottle, every bottle of 10ml.

Beneficial effects of the present invention：

Pharmaceutical preparation provided by the invention has significant effect to the treatment of trigeminal neuralgia, and has no toxic side effect, valency Lattice are cheap.

Specific embodiment

The present invention provides a kind of pharmaceutical preparation for being used to treat trigeminal neuralgia, and bulk pharmaceutical chemicals include the vine of multiflower knotweed, Selaginella tamariscina, do not have Medicine, fructus viticis, Rhizoma Chuanxiong, oyster, earthworm, windproof, wilsonii, pyrola, Radix Glycyrrhizae, the root of Dahurain angelica, schizonepeta, the dried immature fruit of citron orange, Conyza japonica, wood is blue, Salvia chinensis, Cortex Magnoliae Officinalis, the Bi roots of grass, Japanese cryptotaenia stem and leaf and west safflower.

It is preferred that the pharmaceutical preparation is only made of above-mentioned raw materials medicine.

The weight of each bulk pharmaceutical chemicals is respectively vine of multiflower knotweed 35g~45g, Selaginella tamariscina 25g~35g, myrrh 30g in the pharmaceutical preparation ~40g, fructus viticis 20g~30g, Rhizoma Chuanxiong 35g~45g, oyster 25g~35g, earthworm 15g~25g, windproof 20g~30g, thorn five Add 35g~45g, pyrola 15g~25g, Radix Glycyrrhizae 20g~30g, root of Dahurain angelica 25g~35g, schizonepeta 20g~30g, dried immature fruit of citron orange 15g~ 25g, Conyza japonica 15g~25g, wooden indigo plant 20g~30g, salvia chinensis 15g~25g, Cortex Magnoliae Officinalis 15g~25g, Bi roots of grass 25g~35g, duck Celery 20g~30g and west safflower 35g~45g.

Further preferably, in the pharmaceutical preparation weight of each bulk pharmaceutical chemicals be respectively vine of multiflower knotweed 40g~45g, Selaginella tamariscina 30g~ It is 35g, myrrh 35g~40g, fructus viticis 25g~30g, Rhizoma Chuanxiong 40g~45g, oyster 30g~35g, earthworm 20g~25g, windproof 25g~30g, wilsonii 40g~45g, pyrola 20g~25g, Radix Glycyrrhizae 20g~25g, root of Dahurain angelica 25g~30g, schizonepeta 20g~ 25g, dried immature fruit of citron orange 15g~20g, Conyza japonica 15g~20g, wooden indigo plant 20g~25g, salvia chinensis 15g~20g, Cortex Magnoliae Officinalis 15g~20g, the Bi roots of grass 25g~30g, Japanese cryptotaenia stem and leaf 20g~25g and west safflower 35g~40g.

Most preferably, in the pharmaceutical preparation weight of each bulk pharmaceutical chemicals be respectively vine of multiflower knotweed 40g, it is Selaginella tamariscina 30g, myrrh 35g, climing Jing Zi 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, Schizonepeta 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, salvia chinensis 20g, Cortex Magnoliae Officinalis 20g, Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower 40g。

Fang Zhong, the vine of multiflower knotweed, Selaginella tamariscina, west safflower are promoting blood circulation and removing blood stasis, clearing and activating the channels and collaterals, and myrrh is longer than promoting blood circulation, removing blood stasis and relieving pain, fructus viticis Coordination of cold and heat, wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm are walked to alter, wind-expelling pain-stopping, and oyster is transquilization with heavy material, analgesic, and earthworm searches the wind phlegm for picking channels and collaterals, Windproof expelling cold and relieving exterior syndrome, expelling wind and relieving convulsion, wilsonii replenish qi to invigorate the spleen, and tonify the kidney to relieve mental strain, and pyrola dispelling wind and eliminating dampness, promoting blood circulation for regulating menstruation, Radix Glycyrrhizae are delayed Anxious analgesic, the root of Dahurain angelica disperse ailment said due to cold or exposure, promoting blood circulation and stopping pain, and schizonepeta expels pathogenic wind from the body surface, and regulating blood condition stops convulsion, dried immature fruit of citron orange relieving stagnant Qi disperse accumulation, and Conyza japonica heat-clearing stops Bitterly, dispelling pathogenic wind and eliminating phlegm, lily magnolia promoting blood circulation and detoxication, salvia chinensis is promoting blood circulation and removing blood stasis, mass dissipating and swelling eliminating, Cortex Magnoliae Officinalis gas consumption product, eliminating dampness except full , Common St.Paulswort Herbs It expels pathogenic wind from the body surface, Bi roots of grass warming spleen and stomach for dispelling cold, lower gas analgesic, Japanese cryptotaenia stem and leaf dispelling wind stopping cough, blood-activating analgetic, all medicines share, realization replenishing and activating blood, The effect of dispelling wind and removing obstruction in the meridians, promoting blood circulation and stopping pain.

Each bulk pharmaceutical chemicals pharmacology is as follows：

The vine of multiflower knotweed：Sweet in flavor, slight bitter, it is mild-natured；Converge to heart and liver channels have effects that energy mental-tranquilization, dispelling wind and removing obstruction in the meridians, cure mainly mistake The cards such as dormancy dreaminess, deficiency of blood bodily pain, numbness, arthralgia pain due to rheumatism, wind sore scabies tinea.

Selaginella tamariscina：Latin name Selaginellae Herba, for Spikemoss plant Selaginella tamariscina or the drying herb of Selaginella pulvinata, taste Pungent, mild-natured, Return liver, the heart channel of Hang-Shaoyin have effects that invigorate blood circulation, and for closed dysmenorrhea , wei lump in the abdomen lump in the abdomens, injury from falling down is spitted blood, collapsed Leakage, has blood in stool, the cards such as rectal prolapse.

Myrrh：Latin name Myrrha, bitter is pungent, mild-natured, enter liver, spleen, the heart, kidney channel, there is promoting blood circulation and stopping pain, detumescence and promoting granulation Effect cures mainly the cards such as chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, abdominal mass, traumatic injury, carbuncle swells sore, acute appendicitis, red eye, swell pain.

Fructus viticis：Acrid flavour, hardship, cold nature return bladder, liver, stomach, have the effect of dispelling wind and heat from the body, head clearing, cure mainly Anemopyretic cold is had a headache, and gingivitis, the more tears of hot eyes, mesh is secretly unknown, the cards such as have a dizzy spell.

Rhizoma Chuanxiong：Acrid flavour, warm-natured, Return liver, courage, pericardium channel have the effect of blood-activating and qi-promoting, wind-expelling pain-stopping, cure mainly menstruation not It adjusts；Closed dysmenorrhea；The stagnant raw meat pain of the postpartum stasis of blood；Abdominal mass lump；Pain in chest and hypochondrium；Dizziness of having a headache；Wind-cold-dampness arthralgia；Traumatic injury；Ulcer sore The cards such as ulcer.

Oyster：Taste is into cold nature enters liver, courage, kidney channel, has calming the liver, tranquillizing the mind by relieving convulsion, and softening and resolving hard mass restrains astringent method The effect of, dizziness and tinnitus, brothers' chatter are cured mainly, palpitation and insomnia is had the fidgets, and frightened epilepsy is demented, scrofula goiter and tumor, breast caking, from Sweat night sweat, frequent micturition of passing out semen, under uterine bleeding band, acid regurgitation stomachache, the cards such as eczema sore.

Earthworm：Taste is into the effect of cold in nature, Return liver, spleen, bladder warp have heat-clearing arresting convulsion, and dredging collateral relievings asthma, diuresis, curing mainly height The effect of hot coma, joint pain, extremity numbness, hemiplegia, lung heat cough and asthma, oedema oliguria.

It is windproof：Acrid flavour, sweet, slightly warm in nature, enter lung, liver, spleen, bladder warp, there is expelling cold and relieving exterior syndrome, expel endogenous wind to relieve convulsion, and expelling wind and relieving convulsion stops The effect itched is mainly used for catch cold card and cold-evil's closing, the syndrome of superficies cold and interior heat of interior hot pent-up etc..

Wilsonii：For the root, rhizome or cauline leaf of studies on plants of Acanthopanax Miq. in Araliaceae wilsonii, latin name Acanthopanacis Senticosi Radix et Rhizomaseu Caulis, acrid flavour, hardship, micro-sweet are warm-natured, enter spleen, kidney, the heart channel of Hang-Shaoyin, have QI invigorating The effect of invigorating the spleen is tonified the kidney to relieve mental strain, dispelling wind and eliminating dampness for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, is slow in action, physically weak thin The cards such as weak, traumatic injury, fracture, oedema, tinea pedis, uncontrolled urination.

Pyrola：It is sweet in flavor, bitter, it is warm-natured, enter lung channel, stomach, Liver Channel, kidney channel, there is qi-restoratives, kidney-nourishing, dispelling wind and eliminating dampness, promoting blood circulation The effect of menstruation regulating, The strong bone of kidney tonifying, cough-relieving, hemostasis, for lumbago due to the kidney deficiency, arthralgia pain due to rheumatism, muscles and bones impotence, new chronic cough cough, spit blood, be defeated in battle The cards such as blood, uterine bleeding, traumatic hemorrhage.

Radix Glycyrrhizae：Sweet in flavor, mild-natured, return 12 warps have clearing heat and detoxicating a, mediation property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and In, relieving spasm to stop pain is mainly used for weakness of the spleen and the stomach abdominal distension and anorexia, weak；Contraction pain in abdomen can be alleviated, mitigate some drugs Strong and toxicity, mitigate toxic side effect of the drug to body or the stimulation to gastrointestinal tract, tonifying Qi can be played by adding in Radix Glycyrrhizae It neutralizes, reconciles the effect of each component.

The root of Dahurain angelica：Acrid flavour, it is warm-natured, enter lung, spleen, stomach, there is relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band disappears The effect of swollen apocenosis, cure mainly headache, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, The cards such as skin itchy, mange.

Schizonepeta：The effect of acrid flavour, slightly warm in nature enter lung, Liver Channel, have and expel pathogenic wind from the body surface, and declare malicious promoting eruption, and regulating blood condition stops convulsion, cures mainly Flu fever and chills, headache, eye itching, pharyngalgia, cough, measles, rubella, ulcerative carbuncle, brigadier spit blood, and clot blood is had blood in stool, uterine bleeding, in postpartum The cards such as wind, bruise.

The dried immature fruit of citron orange：It is bitter, pungent, it is cold in nature, enter spleen, stomach, liver, the heart channel of Hang-Shaoyin, there is relieving stagnant Qi disperse accumulation, dissolving phlegm removes the effect of ruffian, is mainly used for Internal stagnation, abdominal fullness and distention, the YangmingFushi syndrome of constipation；The taste stagnation of the circulation of vital energy, phlegm wet place food are stagnated, the phlegm and retained fluid chest of mechanism of qi impatency The treatment of the symptoms such as numbness.

Conyza japonica：Bitter, it is pungent, it is cold in nature, there is the effect of clearing away heat to and alleviating pain, dispelling pathogenic wind and eliminating phlegm, cure mainly laryngitis, pneumonia, throat swells Bitterly, the cards such as tonsillitis.

It is wooden blue：For the blue cauline leaf of pulse family anil wood, mildly bitter flavor is cold in nature, has clearing heat and detoxicating, the work(of cooling blood and hemostasis Effect cures mainly encephalitis B, parotitis, acute laryngopharyngitis, lymphnoditis, hot eyes, aphtha, erysipelas, mange, worm snake bite, haematemesis Deng card.

Salvia chinensis：The herb of Lamiaceae Salvia plant Salvia chinensis, Latin literary fame Salvia, acrid flavour, hardship, cold nature, With promoting blood circulation and removing blood stasis, the effect of clearing heat and promoting diuresis, mass dissipating and swelling eliminating, dysmenorrhoea is cured mainly, under humid tropics, hepatic sclerosis, liver cancer is had blood in stool, damp and hot Jaundice, treating rheumatic ostealgia, bruise wound is swollen to wait card.

Cortex Magnoliae Officinalis：Bitter, pungent, warm-natured, converge to the spleen channel；Stomach；Large intestine channel has gas consumption product；Eliminating dampness except full；Relieving asthma Effect cures mainly stagnation of QI due to dyspepsia；Abdominal distention constipation；Damp retention in middle-jiao, abdominal swelling and diarrhea；Phlegm stops up the circulation of vital energy in the wrong direction；The cards such as chest full of cough.

Common St.Paulswort Herb：Latin name Siegesbeckiae Herba, taste tremble with fear, are pungent, is bitter, return liver warp, kidney channel, have wind-damp dispelling, profit The effect of joint, removing toxic substances, cures mainly powerless arthralgia pain due to rheumatism, muscles and bones, soreness and weakness of waist and knees, quadriplegia, hemiplegia, rubella wet sore etc. Card.

The Bi roots of grass：Acrid flavour, property heat, return stomach, large intestine channel, have the effect of warming spleen and stomach for dispelling cold, lower gas analgesic, cure mainly coldness and pain in the epigastrium, Hiccup is vomitted, dysentery is had a headache, toothache, the cards such as nasosinusitis.

Japanese cryptotaenia stem and leaf：Acrid flavour, it is bitter；It is mild-natured, there is dispelling wind stopping cough；Eliminating damp, detoxifying；The effect of blood-activating analgetic, cures mainly pneumonia, lung Abscess, gonorrhoea, hernia, acute toothache, ulcer malignant boil swell, herpes zoster, the cards such as pruitus.

West safflower：Latin name Tamaricis Cacumen, for the dry delicate branches and leaves of the strange willow of Gua Liu sections plant, sweet in flavor, property It is flat, can be promoting blood circulation and removing blood stasis, dissipate Yu Kaijie, analgesic.For treating troubled thoughts pent-up, chest diaphragm ruffian is bored, spits blood, and typhoid fever is gone mad, and shies and is afraid of dimly, Women's Amenorrhea, stasis irregular menstruation, prolonged lochia, hemostasis are had a pain, measles, the cards such as traumatic injury.

Said medicine preparation provided by the invention may be employed conventional preparation method and be prepared into various regular dosage forms, preferably It is prepared into decoction liquor or the dosage form of oral liquid.

The present invention also provides the preparation method of said medicine preparation, when the dosage form of the pharmaceutical preparation is decoction liquor, Specially：

Each bulk pharmaceutical chemicals component is crushed respectively, is mixed, mixture is obtained, adds water to cook 2 times, is added for the first time Enter the water compared with 3~5 times of quality of mixture quality, when decoction 1~2 is small, filtering is added in again in filter residue compared with mixing The water of 2~4 times of quality of amount of substance, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure, and obtains Crude drug concentration is the solution of 1g/ml.

The present invention also provides the preparation method of said medicine preparation, when the dosage form of the pharmaceutical preparation is oral liquid, Specially：

Each bulk pharmaceutical chemicals component is crushed, mixed by the first step respectively, is obtained mixture, is added water to cook 2 times, The water compared with 3~5 times of quality of mixture quality is added in for the first time, and when decoction 1~2 is small, filtering adds in phase again in filter residue For the water of 2~4 times of quality of mixture quality, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, decompression Concentration obtains dry cream, is ground into powder；

Second step takes 500g powder, adds in 500ml distillation water dissolutions, then adds in sucrose 50g, ethylparaben 5g is stirred It mixes and is uniformly dissolved, stood under conditions of 0 DEG C~4 DEG C for 24 hours, filtering through ultraviolet ray sterilization bactericidal, is distributed into bottle, every bottle of 10ml.

The present invention will be described in detail below with reference to the drawings of preferred embodiments, whereby to the present invention how application technology means Technical problem is solved, and the realization process for reaching technique effect can fully understand and implement according to this.

The preparation of 1 decoction liquor 1 of embodiment

By vine of multiflower knotweed 40g, Selaginella tamariscina 30g, myrrh 35g, fructus viticis 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, schizonepeta 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, stone See that wear 40g points of 20g, Cortex Magnoliae Officinalis 20g, Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower crushes respectively, mixes, obtains mixture, It adds water to cook 2 times, adds in the water of 2.5kg for the first time, when decoction 2 is small, filtering in filter residue adds in the water of 1.5kg, decocts again 2 it is small when, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure, and obtains the decoction liquor 1 that crude drug concentration is 1g/ml.

2 toxicological experiment of embodiment

Experimental drug

Decoction liquor 1 prepared by the intragastric administration on mice embodiment of the present invention 1.

Mouse Acute Toxicity is tested

Treatment group mouse is administered according to above method, each 0.8ml/10g, blank control group gavage normal salt Water, before experiment after fasting (can't help water) 12h, gastric infusion, continuous 14d record test mice behavior, work 1 time a day for treatment group Situations such as dynamic, food ration, weight, excrement, death, not dead mouse is put to death after 14d to perform an autopsy on sb..

The mouse of pharmaceutical preparation 80g (crude drug)/kg dosage administration, the same day see that mouse hair color is smooth, excrement is brown, quality It is diluter soft, it ingests, is movable less, mouse activity, food ration, body weight increase, excrement etc. recover normally, with blank after the 2nd day Control group compares no significant difference；And perform an autopsy on sb. after being put to death simultaneously without dead and other generations extremely, two groups in 14d, each master Want internal organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.

Cavy repetitively administered toxicity test

Administration group cavy is administered according to above method, each 0.8ml/10g, blank control group gavage normal salt Water, before experiment after fasting (can't help water) 12h, treatment group's gastric infusion 1 time a day continuous 5 weeks, records tested cavy behavior, work Situations such as dynamic, food ration, weight, excrement, death, non-Guinea Pigs Died put to death after 5 weeks and performs an autopsy on sb..

Experimental animal behavioral activity, diet, stool and urine and situations such as hair color within entire experimental period, is had no apparent different Often, the symptoms such as vomiting is had no, salivates, sheds tears, having difficulty in breathing.There is individual animal death during experiment, taking up anatomy through cage sees It examines, dead animal is shown no obvious abnormalities, improper lethal to be administered.

Growth and development is good after the administration of administration group animal, and body weight increase is relatively shown no obvious abnormalities with blank control group.

Animal is put to death after the test, is dissected immediately, and it is main to visually observe brain, heart, liver, spleen, lungs, kidney etc. Organ is wanted, each organ surface is smooth, and no adhesion, color and luster is normal, has no hyperemia, swelling, bleeding, necrosis, adhesion, stomach and intestine are without expansion , intestinal wall is without abnormal phenomenon such as oedema, bleeding, ulcer.

Heart：Cardiac muscle cell's band is clear, and core is placed in the middle, and interstitial has no blood vessel dilatation and cell infiltration；It is the external membrane of heart, intracardiac Film is without exception.Liver：In strand, lobuli hepatis structure understands that portal area has no cell infiltration and fibrous connective for liver cell arrangement Hyperblastosis, liver cell polygon, slurry is abundant, and core is big and justifies.Spleen：Fibrous capsule is complete, and without thickening, acini lienalis clearly may be used See, trabecularism is normal, and red pulp, white pulp understand, has no denaturation, necrosis and cell infiltration.Lungs：Bronchiole structure is complete It is whole, be methodically arranged, alveolar wall structural integrity, lung interval and bronchus stand intact, intracavitary without apparent exudate, have no denaturation, Necrosis and cell infiltration.Kidney：Renal Cortex, medullary substance, glomerulus structure are normal, and messangial cell number does not increase, blood capillary Pipe tube chamber is without expansion, renal cells, renal interstitial no abnormality seen.Brain：Institutional framework is normal, nerve cell, neuroglia Cell plastid form is normal, each layer neuronal cell Non Apparent Abnormality.

Above-mentioned experiment proves that Chinese medicine composition provided by the invention is non-toxic, suitable for security application.

The preparation of 3 decoction liquor 2 of embodiment

By vine of multiflower knotweed 45g, Selaginella tamariscina 35g, myrrh 40g, fructus viticis 30g, Rhizoma Chuanxiong 45g, oyster 35g, earthworm 25g, windproof 30g, wilsonii 45g, pyrola 25g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, schizonepeta 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, stone See that wear 40g points of 20g, Cortex Magnoliae Officinalis 20g, Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower crushes respectively, mixes, obtains mixture, It adds water to cook 2 times, adds in the water of 3kg for the first time, when decoction 2 is small, filtering in filter residue adds in the water of 2kg, it is small to decoct 2 again When, the filtrate for filtering acquisition twice is mixed, is concentrated under reduced pressure by filtering, obtains the decoction liquor 2 that crude drug concentration is 1g/ml.

The preparation of 4 decoction liquor 3 of embodiment

By vine of multiflower knotweed 40g, Selaginella tamariscina 30g, myrrh 35g, fructus viticis 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 20g, root of Dahurain angelica 25g, schizonepeta 20g, dried immature fruit of citron orange 15g, Conyza japonica 15g, wooden indigo plant 20g, stone See that wear 35g points of 15g, Cortex Magnoliae Officinalis 15g, Bi roots of grass 25g, Japanese cryptotaenia stem and leaf 20g and west safflower crushes respectively, mixes, obtains mixture, It adds water to cook 2 times, adds in the water of 2.5kg for the first time, when decoction 2 is small, filtering in filter residue adds in the water of 1.5kg, decocts again 2 it is small when, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure, and obtains the decoction liquor 3 that crude drug concentration is 1g/ml.

The preparation of 5 oral liquid 1 of embodiment

By vine of multiflower knotweed 40g, Selaginella tamariscina 30g, myrrh 35g, fructus viticis 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, schizonepeta 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, stone See that wear 40g points of 20g, Cortex Magnoliae Officinalis 20g, Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower crushes respectively, mixes, obtains mixture, It adds water to cook 2 times, adds in the water of 2.5kg for the first time, when decoction 2 is small, filtering in filter residue adds in the water of 1.5kg, decocts again 2 it is small when, filtering, will filter twice acquisition filtrate mix, be concentrated under reduced pressure, obtain dry cream, be ground into powder, take 500g powder, 500ml distillation water dissolutions are added in, then add in sucrose 50g, ethylparaben 5g, stirring and dissolving is uniform, quiet under conditions of 0 DEG C It puts for 24 hours, filtering through ultraviolet ray sterilization bactericidal, is distributed into bottle, every bottle of 10ml.

6 clinical data of embodiment

This group of trigeminal neuralgia 210 is to be hospitalized in May, 2010~2013 year June and out-patient, is ask by medical history It asks, symptom and sign and the inspections such as x-ray, CT, MRI are made a definite diagnosis.It is randomly divided into treatment group and control group.Treatment group 110, male 57 Example, women 53；Year at age (59.38 ± 13.21)；The course of disease (6.2 ± 1.21) year.Control group 100, male 53, women 47；Year at age (58.63 ± 11.16)；The course of disease (6.3 ± 1.03) year.2 groups of Genders, age, the course of disease, pain branch feelings Condition, extraction history, the past treatment history, the radiation comparing differences nonsignificance such as position and trigger point, are comparable.

Therapy

The decoction liquor 1 of the preparation of the embodiment of the present invention 1 is taken by treatment group, each 1 time daily morning and evening, each 500ml, continuous to take medicine 1 month, control group took 300~600mg/d of carbamazepine, continuous medication 1 month.

Observation index and evaluation method

Pain integrates：Painless or only bounce sense, but it is denoted as 0 point without ictal pain；It (washes one's face, brush teeth, eat in risk factor Meal speaks, swallows, shaking, wind etc.) lower panic attacks is stimulated to be denoted as 1 point；Activity (except it is above-mentioned activity beyond trunk, four Limb neck movement) when pain be denoted as 2 points；Pain is denoted as 3 points during static or sleep.

Evaluation method

The each durante dolors, daily seizure frequency, pain of 2 groups of patients is recorded within 1st month after treatment respectively Integration.By patient's oral account and doctor's physical examination, and the actions such as trigger point stimulation carried out, speaks, wash one's face, brushing teeth, having a meal and inducing pain Breaking-out evaluates pain intensity, records registration, and treatment implementer, which cannot participate in, to be evaluated but can record, and estimator is not yet It can participate in implementing treatment.

Curative effect determinate standard

(1) clinical recovery：Pain stops, and facial perception function is normal, and follow-up 3 months or more is without recurrence；(2) it is effective：Pain After pain stops, being recurred in 3 months, but the frequency of attack reduces ＞ 50% earlier above；(3) effectively：The panic attacks frequency is reduced earlier above 25%~50%；(4) it is invalid：The panic attacks frequency reduces ＜ 25% earlier above.

Statistical method

Data are handled using 11.0 system softwares of SPSS, measurement data represents that comparison among groups uses single factor test with (x ± s) Variance analysis, enumeration data are examined using x 2, and P ＜ 0.05 are statistically significant for difference.

As a result

Curative effect compares, and is shown in Table 1.

1 two groups of curative effects of table compare

Group

n

It cures

It is effective

Effectively

It is invalid

Total effective rate

Treatment group	110	85	20	3	2	95.5%
							Control group	100	63	14	6	17	77.0%

As it can be seen from table 1 the decoction liquor prepared using the embodiment of the present invention 1 is treated in terms of trigeminal neuralgia is treated Effect is preferable.

Pain condition compares after 2 groups of treatments, is shown in Table 2.

2 treatment group of table and the comparison of the pretherapy and post-treatment pain of control group

Model case

Mr. Yu, man, 53 years old, paroxysmal cutting pains often occurred for worker, main suit's left side face, and break out continues 1 every time ~2 minutes, daily 3~5 times.Again because anger induces pain before 5 days, be very, to need 2~4 carbamazepines that can alleviate in the morning.But it crosses Pain is aggravated again afterwards, and number increases to left and right 7 times a day, after come to treat, through looking into afflicted areas as on trifacial Jaw branch distributed area is taken the decoction liquor 1 of the preparation of the embodiment of the present invention 1, is respectively taken once daily morning and evening, each 500ml.Treatment 5 Attack times are kept to daily 1~2 time in the future, duration of seizure pain stopping after 30 seconds to 1 minute, 15 days, then are consolidated 5, follow-up 1 Year does not break out.

All above-mentioned this intellectual properties of primarily implementation, there is no this new products of implementation of setting limitation other forms And/or new method.Those skilled in the art will utilize this important information, the above modification, to realize similar execution feelings Condition.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above described is only a preferred embodiment of the present invention, being not that the invention has other forms of limitations, appoint What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc. Imitate embodiment.But it is every without departing from technical solution of the present invention content, technical spirit according to the invention is to above example institute Any simple modification, equivalent variations and the remodeling made still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. a kind of pharmaceutical preparation for being used to treat trigeminal neuralgia, it is characterised in that：Bulk pharmaceutical chemicals are by the vine of multiflower knotweed, Selaginella tamariscina, myrrh, climing Jing Zi, Rhizoma Chuanxiong, oyster, earthworm, windproof, wilsonii, pyrola, Radix Glycyrrhizae, the root of Dahurain angelica, schizonepeta, the dried immature fruit of citron orange, Conyza japonica, wood are blue, stone is shown in It wears, Cortex Magnoliae Officinalis, the Bi roots of grass, Japanese cryptotaenia stem and leaf and west safflower composition；

The weight of each bulk pharmaceutical chemicals be respectively vine of multiflower knotweed 35g~45g, Selaginella tamariscina 25g~35g, myrrh 30g~40g, fructus viticis 20g~ 30g, Rhizoma Chuanxiong 35g~45g, oyster 25g~35g, earthworm 15g~25g, windproof 20g~30g, wilsonii 35g~45g, pyrola 15g~25g, Radix Glycyrrhizae 20g~30g, root of Dahurain angelica 25g~35g, schizonepeta 20g~30g, dried immature fruit of citron orange 15g~25g, Conyza japonica 15g~25g, Wooden indigo plant 20g~30g, salvia chinensis 15g~25g, Cortex Magnoliae Officinalis 15g~25g, Bi roots of grass 25g~35g, Japanese cryptotaenia stem and leaf 20g~30g and west safflower 35g~45g.

2. pharmaceutical preparation as described in claim 1, it is characterised in that：The weight of each bulk pharmaceutical chemicals be respectively vine of multiflower knotweed 40g~ 45g, Selaginella tamariscina 30g~35g, myrrh 35g~40g, fructus viticis 25g~30g, Rhizoma Chuanxiong 40g~45g, oyster 30g~35g, earthworm 20g~25g, windproof 25g~30g, wilsonii 40g~45g, pyrola 20g~25g, Radix Glycyrrhizae 20g~25g, root of Dahurain angelica 25g~ 30g, schizonepeta 20g~25g, dried immature fruit of citron orange 15g~20g, Conyza japonica 15g~20g, wooden indigo plant 20g~25g, salvia chinensis 15g~20g, Cortex Magnoliae Officinalis 15g~20g, Bi roots of grass 25g~30g, Japanese cryptotaenia stem and leaf 20g~25g and west safflower 35g~40g.

3. pharmaceutical preparation as claimed in claim 1 or 2, it is characterised in that：The weight of each bulk pharmaceutical chemicals be respectively vine of multiflower knotweed 40g, Selaginella tamariscina 30g, myrrh 35g, fructus viticis 25g, Rhizoma Chuanxiong 40g, oyster 30g, earthworm 20g, windproof 25g, wilsonii 40g, pyrola 20g, Radix Glycyrrhizae 25g, root of Dahurain angelica 30g, schizonepeta 25g, dried immature fruit of citron orange 20g, Conyza japonica 20g, wooden indigo plant 25g, salvia chinensis 20g, Cortex Magnoliae Officinalis 20g, the Bi roots of grass 30g, Japanese cryptotaenia stem and leaf 25g and west safflower 40g.

4. pharmaceutical preparation as claimed in claim 1 or 2, it is characterised in that：The dosage form of the pharmaceutical preparation for decoction liquor or Oral liquid.

5. the preparation method of the pharmaceutical preparation of claim 1 or 2, it is characterised in that：When the dosage form of the pharmaceutical preparation is pan-fried During boil liquid, specifically,

Each bulk pharmaceutical chemicals component is crushed respectively, is mixed, mixture is obtained, adds water to cook 2 times, adds in phase for the first time For the water of 3~5 times of quality of mixture quality, when decoction 1~2 is small, filtering is added in again in filter residue compared with compounding substances The water of 2~4 times of quality is measured, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure, and obtains crude drug Concentration is the solution of 1g/ml.

6. the preparation method of the pharmaceutical preparation of claim 1 or 2, it is characterised in that：When the dosage form of the pharmaceutical preparation is mouth When taking liquid, specifically,

Each bulk pharmaceutical chemicals component is crushed, mixed by the first step respectively, is obtained mixture, is added water to cook 2 times, and first It is secondary add in compared with 3~5 times of quality of mixture quality water, decoct 1~2 it is small when, filtering, added in again in filter residue compared with The water of 2~4 times of quality of mixture quality, when decoction 1~2 is small, filtering, the filtrate that will filter acquisition twice mixes, and is concentrated under reduced pressure Dry cream is obtained, is ground into powder；

Second step takes 500g powder, adds in 500ml distillation water dissolutions, then adds in sucrose 50g, ethylparaben 5g, stirring is molten Solution is uniform, is stood under conditions of 0 DEG C~4 DEG C for 24 hours, and filtering through ultraviolet ray sterilization bactericidal, is distributed into bottle, every bottle of 10ml.