CN104435798A - Traditional Chinese medicine preparation for improving neurasthenia and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for improving neurasthenia and preparation method thereof Download PDF

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CN104435798A
CN104435798A CN201410590708.7A CN201410590708A CN104435798A CN 104435798 A CN104435798 A CN 104435798A CN 201410590708 A CN201410590708 A CN 201410590708A CN 104435798 A CN104435798 A CN 104435798A
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herba
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张忠
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JINAN FANGYU CULTURE MEDIA Co Ltd
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JINAN FANGYU CULTURE MEDIA Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine preparation for improving neurasthenia. The preparation is prepared from the following raw medicinal materials in parts by weight: 20-40 parts of ligusticum wallichii, 3-7 parts of shallots, 15-25 parts of mint, 15-25 parts of pepper, 10-20 parts of rosemary, 6-18 parts of hericium erinaceus, 20-30 parts of ossa draconis, 25-40 parts of sorghum, 8-13 parts of raw liquorice, 13-28 parts of cortex albiziae and 15-25 parts of cassia twig. The preparation disclosed by the invention has the characteristics of being simple to prepare, convenient to take and carry and easy to take for a long time and has the functions of promoting blood circulation to remove blood stasis and dredging collateral, nourishing the blood and calming the nerves, expelling wind and removing cold and opening orifices and relieving pain, and most importantly, the preparation has a very good function of improving neurasthenia.

Description

Improve neurasthenic Chinese medicine preparation and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to neurasthenic Chinese medicine preparation of a kind of improvement and preparation method thereof.
Background technology
Neurasthenia is a more wide in range appellation, calls it at present like this and comprises a part depression, anxiety disorder, tension headache, insomnia, dyspepsia etc.It refers to, due under being in nervous and pressure for a long time, occur spirit easily excitement and mental easy tired phenomenon, often with emotion worry, irritability, sleep disorder, muscle tone pain etc.; These symptoms can not be attributed to brain, physical disease and other mental sickness.Heavy time light during symptom, fluctuate relevant with psychosocial factor, the many delays of the course of disease.
Current Most scholars thinks that Nervous and Mental Factors causes neurasthenic main cause.More every factors that can cause lasting buck fever and long-term intrapsychic conflict, make strong and lasting in tension of neural activity process, exceed the tolerance limit of nervous system tension force, neurasthenia can occur.As overtired and to can not get rest be overstrain of excitatory process; Dissatisfied to present situation is then overstrain of inhibitory process; Frequent change living environment and don't adaptation, the activity of central nervous system, plays a leading role in body Activities.And corticocerebral neurocyte has quite high toleration, generally and be not easy to cause neurasthenia or exhaustion.After the mental work of anxiety, although the fatigue of creating, just can recover after pausing to have a rest or sleep, but the neural activity of strong tense situation, once surmount tolerance limit, just may produce neurasthenia.
The neurasthenic form of expression has very large cultural difference, and its two kinds of main Types have suitable overlap each other.The feature of one type is: feel more tired after main suit requires mental skill, often with professional achievements or deal with the decline to a certain degree of routine matter efficiency.The feature of another type is: after slight physical work, namely sense is weak and very tired, accompanies by myalgia and can not loosen.
Neurasthenia is a kind of functional disorder disease, and main clinical manifestation is dizzy, headache, insomnia, forgetful, dreaminess, weak, emotional, anxious, hypomnesis, and be more common between twenty and fifty mental worker, the cause of disease is relevant with Nervous and Mental Factors.
Authorization Notice No. CN 102008643 B(application number 201010580406.3) Chinese patent literature disclose one and treat neurasthenic mixture, it is characterized in that, described mixture is made up of the crude drug of following weight portion: Caulis Polygoni Multiflori 13-17 part, Cortex Albiziae 13-17 part, stone Herba Rosmarini Officinalis 1-5 part, Herba Agrimoniae 13-17 part, PINGDIMU 13-17 part, Rhizoma Polygonati Odorati 13-17 part, boy's Herba Leonuri 13-17 part, Herba Bidentis Bipinnatae 13-17 part.Authorization Notice No. CN 102727657 B(applies for 201210251912.7) Chinese patent literature disclose one and treat neurasthenic medicament, it is characterized in that, it is made up by weight of following bulk drugs: Cacumen Tamaricis 1-10 part, Folium Artemisiae Argyi 1-10 part, Folium Pyrrosiae 1-5 part, Herba Solani Lyrati 1-5 part, Radix Aconiti Coreani 1-10 part, Semen Lablab Album 1-5 part, Semen Hyoscyami 1-5 part, Radix Angelicae Sinensis 1-10 part, Radix Saposhnikoviae 1-10 part, Radix Glycyrrhizae 1-10 part, Cortex Eucommiae 1-10 part, Fructus Corni 1-10 part.
In a word, Chinese medicine achieves good curative effect improving in primary disease, but also there are some problems: clinically to activating blood circulation to dissipate blood stasis and dredge the collateral, nourishing blood to tranquillize the mind, expelling wind and cold, and understand things pain-stopping is desirable not enough, has much room for improvement to improving the misery that neurasthenia brings.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, neurasthenic Chinese medicine preparation of improvement and preparation method thereof of easy clothes for a long time.This Chinese medicine preparation has activating blood circulation to dissipate blood stasis and dredge the collateral, nourishing blood to tranquillize the mind, expelling wind and cold, effect of understand things pain-stopping, most importantly has good effect to improving neurasthenia.
Technical scheme of the present invention is:
Improve neurasthenic Chinese medicine preparation, be prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 20-40 part, Herba Alii fistulosi 3-7 part, Herba Menthae 15-25 part, Pericarpium Zanthoxyli 15-25 part, Herba Rosmarini Officinalis 10-20 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 6-18 part, Os Draconis 20-30 part, Sorghum vulgare Pers. 25-40 part, Radix Glycyrrhizae 8-13 part, Cortex Albiziae 13-28 part and Ramulus Cinnamomi 15-25 part.
Foregoing Chinese medicine preparation, preferred scheme is, is prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 25-35 part, Herba Alii fistulosi 4-6 part, Herba Menthae 18-23 part, Pericarpium Zanthoxyli 18-23 part, Herba Rosmarini Officinalis 13-18 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 10-14 part, Os Draconis 23-28 part, Sorghum vulgare Pers. 30-35 part, Radix Glycyrrhizae 9-11 part, Cortex Albiziae 18-20 part and Ramulus Cinnamomi 18-23 part.
Foregoing Chinese medicine preparation, better preferred scheme is prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 30 parts, Herba Alii fistulosi 5 parts, Herba Menthae 20 parts, 20 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 12 parts, Os Draconis 25 parts, Sorghum vulgare Pers. 32 parts, Radix Glycyrrhizae 10 parts, Cortex Albiziae 19 parts and Ramulus Cinnamomi 20 parts.
According to the preparation method of the neurasthenic Chinese medicine preparation of improvement noted earlier, step is as follows:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 1-3 hour adding 80-100 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, (preferably 3 minutes) after 1-5 minute are boiled in big fire, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 30-40 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 20-30 minute, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 5-10 minute with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 30-40 DEG C (preferably 35 DEG C) is placed in sealing and standing 1-3 days (preferably 2 days) in crock, be placed in the hot pot dryouied, little fire is fried to 10-20 minute, and taking-up cools, and it is stand-by to grind to form smalls;
(5) step (2)-(4) gains are together placed in marmite; add mixed material medicine gross weight 1-3 water doubly; intense fire is heated to boiling; continue after 3-5 minute (preferably 4 minutes); change slow fire boiling, the process Chinese medicine of decoction constantly stirs, in time becoming thick paste; cease fire, cool bottling and namely obtain oral thick paste.
Foregoing preparation method, preferred scheme is: step (1) adds hot-water soak 1.5-2.5 hour the hot-water soak of 90 DEG C (preferably add 2 hours) of 85-95 DEG C.
Foregoing preparation method, preferred scheme is: get upper strata fluid (preferred distillate gets upper strata fluid after being cooled to 35 DEG C) after step (1) distillate is cooled to 33-38 DEG C.
Foregoing preparation method, preferred scheme is: step (2) is placed in the upper big fire of iron plate and dries 23-28 minute (be preferably placed in the upper big fire of iron plate and dry 25 minutes).
Foregoing preparation method, preferred scheme is: step (3) Herba Alii fistulosi mud ultraviolet sterilization 7-9 minute (preferred Herba Alii fistulosi mud ultraviolet sterilization 8 minutes).
Foregoing preparation method, preferred scheme is: the little fire of step (4) is fried to 13-18 minute (preferred little fire was fried to 15 minutes).
Foregoing preparation method, preferred scheme is: step (5) adds mixed material medicine gross weight 1.5-2.5 water (preferably adding the water of mixed material medicine gross weight 2 times) doubly.
Using method: reach the best for making the present invention and improve effect, boiled water is washed open and is taken half an hour after breakfast, lunch and dinner for preparation and the thick paste that obtains, each 5 grams, it within 10 days, is a course for the treatment of, the volatile oil of gained, every night spreads upon on temple in bed, has smeared each three circles in rear soft left and right.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Chuanxiong: Rhizoma Chuanxiong is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.
Herba Alii fistulosi: another name and thing grass, onion, dish primary, HUOCONG, the four seasons Herba Alii fistulosi.Flavor efficacy is pungent, and temperature, enters lung, stomach warp.Exterior-excess hollow, rise to fall more and lack, merit is specially dispersed and is activated yang, can expelling wind and cold pathogens, and diaphoresis expelling pathogenic factors from muscles, for improving the mild of typhoid fever, cold and heat headache; Again can item, sharp key, relieving constipation, activate yang gas and loose YIN-cold, for improving QI and blood cohesion, dizzy headache, QI stagnated by cold, abdominal distention is suffered from abdominal pain, and bladder qi dysfunction and dysuria etc.; In addition still tool removing toxic substances, hemostatic function.Energy activating yang to invigorate blood circulation, anthelmintic removing toxic substances, relieving the exterior syndrome by diaphoresis.Cure mainly the diseases such as anemofrigid cold mild, carbuncle sore tumefacting virus, dysentery faint pulse, cold coagulation stomachache, dysuria, flu, wind and cold, headache, YIN-cold stomachache, malnutrition due to parasitic infestation internal resistance, dysentery etc. are had a better role.1. antipyretic, eliminate the phlegm: the volatilization wet goods effective ingredient of Herba Alii fistulosi, have and stimulate health sweat gland, reach the effect of diaphoresis heat radiation; Scallion oil stimulates upper respiratory tract, makes sticky expectorant be easy to bring up.2. facilitating digestion absorbs: Herba Alii fistulosi also has the effect stimulating body digestive juice secretion, can spleen benefiting and stimulating the appetite, appetite stimulator.3. antibacterial, antiviral 4. cancer-resisting.
Herba Menthae: Herba Menthae is Chinese conventional Chinese medicine, young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthae can cause insomnia, but low dose of eating conduces to sleep.
Pericarpium Zanthoxyli: the traditional Chinese medical science is thought, Pericarpium Zanthoxyli is warm in nature, acrid in the mouth, has warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, removing toxic substances are regulated the flow of vital energy, effect of antipruritic raw meat of dispelling; Can be used for improving food stagnation, stop pain of joint muscle, coldness and pain in the epigastrium caused by drink, singultus, vomiting, wind-cold damp pathogen, have loose bowels, dysentery, ascarid, the disease such as pudendal pruritus.Warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separates fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough gas Pericarpium Zanthoxyli is inverse, and anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.
Herba Rosmarini Officinalis: base is former: be the herb of Labiatae Rosmarinus plant rosemary.Composition: book on Chinese herbal medicine is containing flavonoid: Hesperidin, diosmin, shore Ji xanthosine etc.Alkaloid: rosmarinine, isorosmaricine.Triterpenes: ursolic acid, rosmarinic acid etc.The property of medicine: supplement to the Herbal: " pungent, temperature, nontoxic." function cures mainly: diaphoresis, spleen invigorating, calms the nerves, pain relieving.Cure mainly various headache, prevent early stage alopecia.
Hericium erinaceus (Bull. Ex Fr.) Pers.: base is former: be the sporophore of hedgehog fungus section Hericium fungus Hericium erinaceus (Bull. Ex Fr.) Pers., Hydnum.Composition: containing Hericium erinaceus (Bull. Ex Fr.) Pers. Ketone A, B, C, D, E, F, G, H in Hericium erinaceus, Hericium erinaceus (Bull. Ex Fr.) Pers. alkali etc.Dry sporophore is containing protein, lipid, fiber and glucosan.Also containing sterols: ergosterol etc.Mycelium culture contains Hericium erinaceus (Bull. Ex Fr.) Pers. pyrone A, B etc.The property of medicine: " national Chinese herbal medicine compilation ": " sweet, flat." function cures mainly: strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Cure mainly body void weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
Os Draconis: base is former: for mammal in ancient times resembles the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex, bovine, deer class etc.Composition: Os Draconis, mainly containing calcium carbonate and calcium phosphate, still contain ferrum, potassium, sodium, chlorine, sulfate radical etc.The property of medicine: puckery, sweet, flat.GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquilizing mind, suppressing the hyperactive liver and subsiding YANG, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly cardiopalmus, seized with terror swollen, insomnia, forgetful, infantile convulsion, demented, dizzy, spontaneous sweating, the seminal emission enuresis, bleeding not during menses, chronic diarrhea and dysentery, ulcer does not close up and eczema for a long time.Compatibility and incompatibility of drugs: the careful clothes of the excess-heat person of stagnating.
Sorghum vulgare Pers.: base is former: be the kernel of grass family sorghum Sorghum vulgare Pers..Composition: this product plumelet, fruit contain hydroxymandelonitrile glucoside.The property of medicine: sweet, puckery, temperature.Function cures mainly: invigorating the spleen to arrest diarrhea, reduces phlegm and calms the nerves.Cure mainly diarrhea due to hypofunction of the spleen, cholera, dyspepsia, productive cough due to phlegm-damp, insomnia and dreamful sleep.
Radix Glycyrrhizae: another name Glycyrrhizae, close sweet, close grass, state are old, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, excellent grass system pulse family herbaceos perennial.The traditional Chinese medical science thinks that it has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine, nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Cortex Albiziae: Cortex Albiziae is the dry bark of leguminous plant Herba Albiziae, in curling tubular or half tubular, long 40 ~ 80cm, thick Cortex Albiziae 0.1 ~ 0.3cm.Outer surface taupe brown is to taupe, and nature and flavor are sweet, flat.There is the merit of resolving depression and blood, mind calming, subduing inflammation.There is the effect controlling irritability, melancholy, insomnia, lung abscess, carbuncle, scrofula, injured bone.
Ramulus Cinnamomi, rectification of name: Cortex Cinnamomi, has another name called beautiful osmanthus, Cortex cinnamomi japonici (Ramulus Cinnamomi) etc., belongs to Laurales, the medium megaphanerophyte of Lauraceae; Annotinous branch is cylindrical, its nature and flavor are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, be cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, improve insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, improve coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.
Chinese medicine preparation of the present invention meets the principle that disease improvement debated by Chinese medicine.The medical material selected is divided into thick paste for oral administration and external volatile oil, inside and outside treat simultaneously, improve more comprehensive, affected area administration is rapider, lasting medicine, take into account inside and outside belonging to, neurasthenia's prescription for the treatment of both the principal and secondary aspects of a disease, has fabulous improvement result to neurasthenia, not only there is good improvement result to neurasthenia, very very effective in cure to trigeminal neuralgia, in addition, excellent results of the present invention also shows:
1,in selected materials, Rhizoma Chuanxiong, Herba Alii fistulosi, Pericarpium Zanthoxyli, Radix Glycyrrhizae and Cortex Albiziae have blood stasis dispelling, control neurasthenic effect, other crude drug have calm the nerves, effect of pain relieving, the crude drug of different efficacies is combined, and serves that arresting convulsion is calmed the nerves, hypnotic, improves neurasthenic effect;
2,this prescription meets Chinese medicine principle and neurastheniac body and mind feature completely, under the prerequisite of general principle, can have different prescription according to different crowd, and function is different.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1improve neurasthenic Chinese medicine preparation, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Chuanxiong 20 parts, Herba Alii fistulosi 3 parts, Herba Menthae 15 parts, 15 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 10 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 6 parts, Os Draconis 20 parts, Sorghum vulgare Pers. 25 parts, Radix Glycyrrhizae 8 parts, Cortex Albiziae 13 parts and Ramulus Cinnamomi 15 parts.
The preparation method of the neurasthenic Chinese medicine preparation of above-mentioned improvement:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 1 hour adding 80 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, after big fire boils 1 minute, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 30 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 20 minutes, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 5 minutes with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 30 DEG C to be placed in crock sealing and standing 1 day, be placed in the hot pot dryouied, little fire was fried to 10 minutes, and taking-up cools, and it is stand-by to grind to form smalls;
(5) be together placed in marmite by step (2)-(4) gains, add the water of mixed material medicine gross weight 1 times, intense fire is heated to boiling; continue after 3 minutes, change slow fire boiling, the process Chinese medicine of decoction constantly stirs; in time becoming thick paste, cease fire, cool bottling and namely obtain oral thick paste.
typical case one: Lee XX, female, 45 years old, Jinan, Shandong Province people from Jiyang, the employee of certain company, the operating pressure of every month was very large, and often overtime work is to the late into the night.There is left side of head pain without obvious inducement before 1 year, every day substantially can timing pain, the time of general pain can not be oversize, pain is got up just as pinprick, from the beginning of slightly, bitterly do in paroxysm, spring, outbreak was more acute, oral indometacin sheet can be alleviated, show effect over 1 year frequent, monthly show effect 4-5 time, each lasting 1-2 days, to make front aethomma dim spot, fuzzy depending on spy; During outbreak, twinge is fought sense, companion's Nausea and vomiting time heavy, and be on tenterhooks, local hospital is examined as angioneurotic headache, to wheat clothes peace preparation, first can alleviate, then gradually lose efficacy.Nearly March has a headache on the left of paroxysmal, and head sinks swollen, pain as being stabbed time heavy, and sore spot is fixing not to be moved, and still has sense of fighting during outbreak, companion's Nausea and vomiting.Clothes medicine-feeding is invalid.Have a medical check-up: sanity, spirit is poor, and cranial nerve is normal, and neck is soft, and myasthenia of limbs, muscular tension are normal, and bilateral pathology levies feminine gender.Thin white fur of tongue, deep-thready pulse string.Head CT and magnetic resonance examination normally, are diagnosed as: neurasthenia.
Give the oral embodiment of the present invention 1 gained preparation and with the use of the embodiment of the present invention 1 gained volatile oil, after 5 days, patient's self-induction attack times obviously reduces, and also do not had a sleepless night in the evening, after continuing to have taken 1 course for the treatment of, substantially do not recur, during recurrence, pain degree alleviates, decreased duration, and every day is very well spiritual, continue again to take 1 course for the treatment of, cure completely, not showing effect 1 year more so far.
embodiment 2improve neurasthenic Chinese medicine preparation, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Chuanxiong 40 parts, Herba Alii fistulosi 7 parts, Herba Menthae 25 parts, 25 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts, Os Draconis 30 parts, Sorghum vulgare Pers. 40 parts, Radix Glycyrrhizae 13 parts, Cortex Albiziae 28 parts and Ramulus Cinnamomi 25 parts.
The preparation method improving neurasthenic Chinese medicine preparation is:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 3 hours adding 100 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, after big fire boils 5 minutes, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 40 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 30 minutes, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 10 minutes with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 40 DEG C to be placed in crock sealing and standing 3 days, be placed in the hot pot dryouied, little fire was fried to 20 minutes, and taking-up cools, and it is stand-by to grind to form smalls;
(5) be together placed in marmite by step (2)-(4) gains, add the water of mixed material medicine gross weight 3 times, intense fire is heated to boiling; continue after 5 minutes, change slow fire boiling, the process Chinese medicine of decoction constantly stirs; in time becoming thick paste, cease fire, cool bottling and namely obtain oral thick paste.
embodiment 3improve neurasthenic Chinese medicine preparation, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Chuanxiong 25 parts, Herba Alii fistulosi 4 parts, Herba Menthae 18 parts, 18 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 13 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 10 parts, Os Draconis 23 parts, Sorghum vulgare Pers. 30 parts, Radix Glycyrrhizae 9 parts, Cortex Albiziae 18 parts and Ramulus Cinnamomi 18 parts.
The preparation method improving neurasthenic Chinese medicine preparation is:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 1.5 hours adding 85 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, after big fire boils 2 minutes, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 33 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 23 minutes, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 7 minutes with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 33 DEG C to be placed in crock sealing and standing 1.5 days, be placed in the hot pot dryouied, little fire was fried to 13 minutes, and taking-up cools, and it is stand-by to grind to form smalls;
(5) be together placed in marmite by step (2)-(4) gains, add the water of mixed material medicine gross weight 1.5 times, intense fire is heated to boiling; continue after 3.5 minutes, change slow fire boiling, the process Chinese medicine of decoction constantly stirs; in time becoming thick paste, cease fire, cool bottling and namely obtain oral thick paste.
typical case two:woods XX, man 42 years old, Jinan, Shandong Province personage, cadre at their posts, patient's readme: had recurrent exerbation to have a headache the time of 8 years, because operating pressure larger right side headache increases the weight of to have a surplus for 3 years, in recent year, headache is on average shown effect 1-2 time weekly, each lasting 4 hours, severe headache during outbreak, companion's Nausea and vomiting, insomnia, without speech, limb function and disturbance of consciousness, oral rotundine, Ergotamine heterodyne.Health check-up: blood pressure 130/80mmhg, cranial nerve is normal, and neck is soft, greasy in tongue, rolling pulse.Electroencephalogram is normal, head CT and magnetic resonance examination without exception.Diagnosis: neurasthenia.In this time in 1 year, patient says the doctor seen many times, eats much famous and precious medicine, but effect is not fine, and Chinese medicine preparation of the present invention improves neurasthenia's effect very good to listen friend to say in November, 2011.Just 4 courses for the treatment of have been bought.
Take the embodiment of the present invention 3 gained Chinese medicine preparation and with the use of embodiment 3 gained volatile oil, after 1 course for the treatment of, patient's sensation pain when falling ill is so inviolent, the symptom such as Nausea and vomiting and insomnia is not had yet, after continuing to take 2 courses for the treatment of, basic malaise symptoms disappears, the state of an illness is basicly stable, continues to take to do 1 course for the treatment of and consolidates, without recurrence after drug withdrawal.
embodiment 4improve neurasthenic Chinese medicine preparation, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Chuanxiong 35 parts, Herba Alii fistulosi 6 parts, Herba Menthae 23 parts, 23 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 18 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 14 parts, Os Draconis 28 parts, Sorghum vulgare Pers. 35 parts, Radix Glycyrrhizae 11 parts, Cortex Albiziae 20 parts and Ramulus Cinnamomi 23 parts.
The preparation method improving neurasthenic Chinese medicine preparation is:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 2.5 hours adding 95 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, after big fire boils 4 minutes, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 38 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 28 minutes, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 9 minutes with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 38 DEG C to be placed in crock sealing and standing 2.5 days, be placed in the hot pot dryouied, little fire was fried to 18 minutes, and taking-up cools, and it is stand-by to grind to form smalls;
(5) be together placed in marmite by step (2)-(4) gains, add the water of mixed material medicine gross weight 2.5 times, intense fire is heated to boiling; continue after 4.5 minutes, change slow fire boiling, the process Chinese medicine of decoction constantly stirs; in time becoming thick paste, cease fire, cool bottling and namely obtain oral thick paste.
embodiment 5improve neurasthenic Chinese medicine preparation, get the raw materials ready (getting 20g for every part) by following weight parts: Rhizoma Chuanxiong 30 parts, Herba Alii fistulosi 5 parts, Herba Menthae 20 parts, 20 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 12 parts, Os Draconis 25 parts, Sorghum vulgare Pers. 32 parts, Radix Glycyrrhizae 10 parts, Cortex Albiziae 19 parts and Ramulus Cinnamomi 20 parts.
The preparation method improving neurasthenic Chinese medicine preparation is:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 2 hours adding 90 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, after big fire boils 3 minutes, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 35 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 25 minutes, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 8 minutes with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 35 DEG C to be placed in crock sealing and standing 2 days, be placed in the hot pot dryouied, little fire was fried to 15 minutes, and taking-up cools, and it is stand-by to grind to form smalls;
(5) be together placed in marmite by step (2)-(4) gains, add the water of mixed material medicine gross weight 2 times, intense fire is heated to boiling; continue after 4 minutes, change slow fire boiling, the process Chinese medicine of decoction constantly stirs; in time becoming thick paste, cease fire, cool bottling and namely obtain oral thick paste.
test example 1embodiment 5 gained improves the clinical practice of neurasthenic Chinese medicine preparation: choose neurasthenic Patients with 300 Cases in 10 hospitals, before test 1 week, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 5 products obtained therefrom, and matched group takes other medicine (conventional medication such as chlordiazepoxide, estazolam).Curative effect situation criterion: cure: take embodiment 5 gained tablet and after coordinating embodiment 5 gained volatile oil, malaise symptoms has clear improvement, and the mental status is very good; Effective: to take embodiment 5 gained tablet and after coordinating embodiment 5 gained volatile oil, malaise symptoms makes moderate progress, and the mental status is better; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1:
Gained Chinese medicine preparation effective percentage of the present invention is up to 98%, and cure rate is up to 94%, and successful is better than experimental group, and takes product of the present invention 5 days, and malaise symptoms improves; Take 10 days, malaise symptoms improves or disappears; Take 20 days, malaise symptoms disappears, and normally, some patients self-induction is fully recovered for head CT and magnetic resonance examination display.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. improve neurasthenic Chinese medicine preparation, it is characterized in that: be prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 20-40 part, Herba Alii fistulosi 3-7 part, Herba Menthae 15-25 part, Pericarpium Zanthoxyli 15-25 part, Herba Rosmarini Officinalis 10-20 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 6-18 part, Os Draconis 20-30 part, Sorghum vulgare Pers. 25-40 part, Radix Glycyrrhizae 8-13 part, Cortex Albiziae 13-28 part and Ramulus Cinnamomi 15-25 part.
2. Chinese medicine preparation according to claim 1, it is characterized in that, be prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 25-35 part, Herba Alii fistulosi 4-6 part, Herba Menthae 18-23 part, Pericarpium Zanthoxyli 18-23 part, Herba Rosmarini Officinalis 13-18 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 10-14 part, Os Draconis 23-28 part, Sorghum vulgare Pers. 30-35 part, Radix Glycyrrhizae 9-11 part, Cortex Albiziae 18-20 part and Ramulus Cinnamomi 18-23 part.
3. Chinese medicine preparation according to claim 1, it is characterized in that, be prepared from by the crude drug of following weight proportioning: Rhizoma Chuanxiong 30 parts, Herba Alii fistulosi 5 parts, Herba Menthae 20 parts, 20 parts, Pericarpium Zanthoxyli, Herba Rosmarini Officinalis 15 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 12 parts, Os Draconis 25 parts, Sorghum vulgare Pers. 32 parts, Radix Glycyrrhizae 10 parts, Cortex Albiziae 19 parts and Ramulus Cinnamomi 20 parts.
4. according to the preparation method of the neurasthenic Chinese medicine preparation of the improvement according to any one of claim 1-3, it is characterized in that, step is as follows:
(1) first Pericarpium Zanthoxyli is cleaned, be placed in clean container the hot-water soak 1-3 hour adding 80-100 DEG C, Rhizoma Chuanxiong, Herba Menthae and Ramulus Cinnamomi are being broken into the block of Pericarpium Zanthoxyli size, together be placed in the container of immersion Pericarpium Zanthoxyli, (preferably 3 minutes) after 1-5 minute are boiled in big fire, change slow fire and add thermal distillation, volatile oil and water are together distilled, collect distillate, leave standstill and get upper strata fluid after distillate is cooled to 30-40 DEG C, be distributed into air-tight bottle and obtain external volatile oil;
(2) Os Draconis are broken into the block of coin-size, be placed in the upper big fire of iron plate and dry 20-30 minute, cool that to grind to form smalls stand-by;
(3) by Herba Alii fistulosi defoliation, Bulbus Allii Fistulosi is cut into the block of small rice grain size by knife, being placed in gauze, is pounded Herba Alii fistulosi mud ultraviolet sterilization 5-10 minute with rolling pin, stand-by;
(4) by Herba Rosmarini Officinalis, Hericium erinaceus (Bull. Ex Fr.) Pers., Sorghum vulgare Pers., Radix Glycyrrhizae and the Cortex Albiziae Chinese liquor of 30-40 DEG C (preferably 35 DEG C) is placed in sealing and standing 1-3 days (preferably 2 days) in crock, be placed in the hot pot dryouied, little fire is fried to 10-20 minute, and taking-up cools, and it is stand-by to grind to form smalls;
(5) step (2)-(4) gains are together placed in marmite; add mixed material medicine gross weight 1-3 water doubly; intense fire is heated to boiling; continue after 3-5 minute (preferably 4 minutes); change slow fire boiling, the process Chinese medicine of decoction constantly stirs, in time becoming thick paste; cease fire, cool bottling and namely obtain oral thick paste.
5. preparation method according to claim 4, is characterized in that: step (1) adds hot-water soak 1.5-2.5 hour the hot-water soak of 90 DEG C (preferably add 2 hours) of 85-95 DEG C.
6. preparation method according to claim 4, is characterized in that: get upper strata fluid (preferred distillate gets upper strata fluid after being cooled to 35 DEG C) after step (1) distillate is cooled to 33-38 DEG C.
7. preparation method according to claim 4, is characterized in that: step (2) is placed in the upper big fire of iron plate and dries 23-28 minute (be preferably placed in the upper big fire of iron plate and dry 25 minutes).
8. preparation method according to claim 4, is characterized in that: step (3) Herba Alii fistulosi mud ultraviolet sterilization 7-9 minute (preferred Herba Alii fistulosi mud ultraviolet sterilization 8 minutes).
9. preparation method according to claim 4, is characterized in that: the little fire of step (4) is fried to 13-18 minute (preferred little fire was fried to 15 minutes).
10. preparation method according to claim 4, is characterized in that: step (5) adds mixed material medicine gross weight 1.5-2.5 water (preferably adding the water of mixed material medicine gross weight 2 times) doubly.
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