CN1895575B - Medicine for treating infantile anorexia and its preparation - Google Patents
Medicine for treating infantile anorexia and its preparation Download PDFInfo
- Publication number
- CN1895575B CN1895575B CN2006100278012A CN200610027801A CN1895575B CN 1895575 B CN1895575 B CN 1895575B CN 2006100278012 A CN2006100278012 A CN 2006100278012A CN 200610027801 A CN200610027801 A CN 200610027801A CN 1895575 B CN1895575 B CN 1895575B
- Authority
- CN
- China
- Prior art keywords
- medicine
- parched
- endothelium corneum
- gigeriae galli
- corneum gigeriae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 80
- 229940079593 drug Drugs 0.000 title claims description 52
- 206010061428 decreased appetite Diseases 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 16
- 208000022531 anorexia Diseases 0.000 title claims description 15
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 210000003038 endothelium Anatomy 0.000 claims description 23
- 239000000843 powder Substances 0.000 claims description 16
- 210000000582 semen Anatomy 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 abstract description 3
- 210000000952 spleen Anatomy 0.000 description 46
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 27
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 27
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 27
- 230000007812 deficiency Effects 0.000 description 27
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 27
- 229960003147 reserpine Drugs 0.000 description 27
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 27
- 241000700159 Rattus Species 0.000 description 26
- 230000037396 body weight Effects 0.000 description 19
- 239000007788 liquid Substances 0.000 description 19
- 210000002784 stomach Anatomy 0.000 description 17
- 230000000968 intestinal effect Effects 0.000 description 14
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 11
- 230000036528 appetite Effects 0.000 description 10
- 235000019789 appetite Nutrition 0.000 description 10
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 10
- 230000009182 swimming Effects 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 239000007928 intraperitoneal injection Substances 0.000 description 8
- 230000033228 biological regulation Effects 0.000 description 7
- 230000029087 digestion Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 201000006549 dyspepsia Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000003203 everyday effect Effects 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000006837 decompression Effects 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000000556 factor analysis Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000010271 massa medicata fermentata Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000035508 accumulation Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 239000003610 charcoal Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000001141 propulsive effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 235000017159 Crataegus pinnatifida Nutrition 0.000 description 2
- 241000657480 Crataegus pinnatifida Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102100021022 Gastrin Human genes 0.000 description 2
- 108010052343 Gastrins Proteins 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 206010061217 Infestation Diseases 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 230000004345 fruit ripening Effects 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000004206 stomach function Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 241001417092 Macrouridae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 241001038562 Pseudostellaria heterophylla Species 0.000 description 1
- 235000019057 Raphanus caudatus Nutrition 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000011380 Raphanus sativus Nutrition 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000009088 enzymatic function Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating the fastidium of baby and its preparing process are disclosed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of infantile anorexia and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Children's has the physiological characteristics of " the young sun of young the moon ", " the spleen tending to insufficiency usually ", if the natural endowment deficiency, weakness of the spleen and stomach; The day after tomorrow improper feeding, surfeit delicious food raw food, or misuse bitter cold, warm-dryness syndrome impairing the spleen and stomach too, or imbalance are after being ill sapped one's vitality etc., all may cause dysfunction of the spleen in transportation and anorexia takes place.
Infantile anorexia is the common disease of children's, and it is with loss of appetite, or loss of appetite or serious particular about food be feature, with the passing of time cause become thin, serious disease such as anemia, infantile malnutrition.Anorexia can be a kind of simple, and independently sick the kind also can be the simultaneous phenomenon of various diseases.The traditional Chinese medical science is thought " The spleen has the function to transport and transform nutrients ", " stomach is a reservoir of food and drink ", has only spleen and stomach function normal, could water paddy and spermatogenesis is little, the defeated cloth nutrition whole body.Chinese medicine thinks that the main cause that causes anorexia has: dyspepsia, malnutrition due to parasitic infestation, and spleen is stranded by wet, the natural endowment deficiency, the vigour weakness, weakness of the spleen and stomach etc., wherein common with dyspepsia, malnutrition due to parasitic infestation.And also stagnate with eliminate indigestion in the treatment, invigorating the spleen to clear away damp pathogen is set upright training unit and is method.Though there are some medicines that help digestion selling in the market, also have deficiency in children's's spleen reinforcing aspect setting upright, therefore, usually can not fundamentally cure infantile anorexia.
Summary of the invention
The inventor and by animal and clinical experiment, has found the Chinese medicine that the treatment of better curative effect infantile anorexia is arranged finally, thereby has finished the present invention through research repeatedly.
The purpose of this invention is to provide a kind of Chinese drug-treated group and thing for the treatment of infantile anorexia.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection of the present invention is to get through a large amount of clinical groping.The clinical discovery Fructus Crataegi has the effect of facilitating digestion, and the lipase that Fructus Crataegi contains can promote fat digestion, and can increase the secretion of peptic digestion enzyme, and gastrointestinal function is had certain regulating action; Fructus Hordei Germinatus has promote qi circulation digestion promoting, and spleen benefiting and stimulating the appetite moves back the effect of newborn relieving distension; The merit that the Endothelium Corneum Gigeriae Galli activating the spleen is good for the stomach, the power that helps digestion is more outstanding, normal treats the infantile spleen deficiency infantile malnutrition with drugs strengthening spleen compatibilities such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria; The traditional Chinese medical science thinks that Pericarpium Citri Reticulatae has regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, disease such as compatibilities such as normal and Fructus Setariae Germinatus, Fructus Crataegi, Massa Medicata Fermentata treat that food stagnation does not disappear, abdominal distention, vomiting are had loose bowels; Radix Pseudostellariae is applied to the card of weakness of the spleen and stomach more, the compatibility Rhizoma Dioscoreae, and Semen Lablab Albums etc. help fortune with spleen invigorating; The symptoms such as loose stool that Rhizoma Dioscoreae (parched with bran) causes Spleen Rats have prevention and therapeutical effect; Semen Raphani normal and Fructus Crataegi, Pericarpium Citri Reticulatae are equal to usefulness, are used for stagnation of QI due to dyspepsia, diseases such as distension and fullness in the abdomen.
The inventor is simplifying prescription and is obtaining to have done a large amount of work aspect the maximum synergism, and has finally determined the ratio of medicine, so Chinese medicine preparation of the present invention is made by following raw material:
Fructus Crataegi (parched to brown) 10-30%, Fructus Hordei Germinatus 10-30%, Endothelium Corneum Gigeriae Galli 10-25%, Pericarpium Citri Reticulatae 5-15%, Radix Pseudostellariae 5-15%, Rhizoma Dioscoreae (parched with bran) 10-25%, Semen Raphani 5-15%.
Raw material of the present invention more preferably be: Fructus Crataegi (parched to brown) 15-25%, Fructus Hordei Germinatus 15-25%, Endothelium Corneum Gigeriae Galli 15-20%, Pericarpium Citri Reticulatae 5-10%, Radix Pseudostellariae 5-10%, Rhizoma Dioscoreae (parched with bran) 15-20%, Semen Raphani 5-10%.
Of the present invention most preferably being: Fructus Crataegi (parched to brown) 19-20%, Fructus Hordei Germinatus 19-20%, Endothelium Corneum Gigeriae Galli 15-16%, Pericarpium Citri Reticulatae 9-10%, Radix Pseudostellariae 9-10%, Rhizoma Dioscoreae (parched with bran) 15-16%, Semen Raphani 9-10%.
In the raw material of above-mentioned Chinese medicine preparation, 1. Fructus Crataegi (parched to brown) is the process of preparing Chinese medicine processed goods of Fructus Crataegi, i.e. Fructus Crataegi parching to brown.Fructus Crataegi is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Gather during fruit maturation autumn, section, drying.This product should meet " pertinent regulations under the 22nd page of Fructus Crataegi item of Chinese pharmacopoeia version in 2005.2, Fructus Hordei Germinatus is that the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. gets through the drying of germinateing.After wheat grain is soaked in water, keep preference temperature, humidity, when treating that plumelet grows to about 0.5cm, dry or cold drying.This product should meet " pertinent regulations under the 107th page of Fructus Hordei Germinatus item of Chinese pharmacopoeia version in 2005.3, Endothelium Corneum Gigeriae Galli is the dry inner wall of sandbag of the chicken Gallus gallus domesticus Brisson of Phasianidae animal man.After killing chicken, take out chicken and escape, peel inwall, cleaning, drying immediately.This product should meet " pertinent regulations under the 133rd page of Endothelium Corneum Gigeriae Galli item of Chinese pharmacopoeia version in 2005.4, Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulate Blanco and variety thereof.Pluck mature fruit, peel off peel, dry or cold drying.This product should meet " pertinent regulations under the 132nd page of Pericarpium Citri Reticulatae item of Chinese pharmacopoeia version in 2005.5, Radix Pseudostellariae is the dried root of pinkwort Radix Ginseng Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm..Excavate during most of the withering of stem and leaf in summer, clean, remove fibrous root, put and dry or directly dry after the boiling water part omitted is scalded.This product should meet " pertinent regulations under the 46th page of Radix Pseudostellariae item of Chinese pharmacopoeia version in 2005.6, Rhizoma Dioscoreae (parched with bran) is the process of preparing Chinese medicine processed goods of Rhizoma Dioscoreae, promptly uses Rhizoma Dioscoreae (parched with bran).Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscoreaopposite Thunb..Winter, stem and leaf was excavated after withering, and cut the root head, cleaned, and removed crust and fibrous root, drying; Also have and select loose straight dry Rhizoma Dioscoreae, put in the clear water, be dipped into the no dried heart, vexed, trim two ends, be twisted into cylindricly with plank, dry habit title " light yam ".This product should meet " pertinent regulations under the 21st page of Rhizoma Dioscoreae item of Chinese pharmacopoeia version in 2005.7, Semen Raphani is the dry mature seed of crucifer Radix Raphani Raphanus sativus L..Tap plant during fruit maturation summer, dries, and rubs seed, removes impurity, dries again.This product should meet " pertinent regulations under the 192nd～193 page of Radix Raphani subitem of Chinese pharmacopoeia version in 2005.
Full side is monarch with the Massa Medicata Fermentata, in order to relieving dyspepsia; With Fructus Crataegi, Fructus Hordei Germinatus is minister, helps the power of Massa Medicata Fermentata; With the Endothelium Corneum Gigeriae Galli is assistant, complements each other with Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi three medicines, plays the merit of dyspepsia and intestinal stasis relieving altogether; Pericarpium Citri Reticulatae promoting the circulation of QI stomach function regulating, Semen Raphani therapeutic method to keep the adverse QI flowing downwards intestinal stasis relieving, two medicines are for making, to strengthen the power of gastrointestinal conduction; Then the stagnating of gastrointestinal can disappear, and the motion of intestinal can be smooth.At the beginning of all eating accumulations, often because of the fortune power deficiency of gastrointestinal; And eating accumulation is with the passing of time, also can the fortune power of taste be diminished, so with the gas of Radix Pseudostellariae, the flat tonifying the spleen and stomach of Rhizoma Dioscoreae, with solid its, then among food stagnation removing, take into account healthy energy, can receive satisfactory to both parties merit.This children's Fang Zhi adult is very suitable because of distension and fullness in the abdomen due to the eating accumulation, anorexia, evil person; If because of weakness of the spleen and stomach, digest unable and card persons such as the abdominal distention that causes, diarrhoea, then should not be with this side, when based on warming and invigorating the spleen and stomach.
Another object of the present invention provides the preparation method of this Chinese medicine preparation:
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.As these crude drug being ground into powder, making powder and take after mixing it with water or incapsulate etc.But, dosage is reduced as far as possible because the patient mostly is children's so preferably be used as medicine with active component.
The active component preparation method of medicine of the present invention: proportionally take by weighing medical material except that Endothelium Corneum Gigeriae Galli in extraction pot, carry after drying, make dry extract and be ground into fine powder through conventional water; Add the Endothelium Corneum Gigeriae Galli fine powder again, mix homogeneously is promptly made the active component of medicine of the present invention.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, powder, tablet, capsule, oral liquid, granule, syrup etc.
Medicine of the present invention has invigorating the spleen and regulating the stomach, helps digestion to remove the effect of expanding.Cure mainly infantile anorexia, dyspepsia, Chinese medical discrimination is incoordination between the spleen and stomach, insufficiency of the spleen food stagnation disease.The clinical manifestation lack of appetite, abdominal distention, loose stool, fatigue and weakness, asthenic body, light red tongue, diseases such as weak pulse.
Advantage of the present invention: flavour of a drug of the present invention are formed simple, and cheap and easy to get, preparation technology is also simple, meets the custom that Chinese traditional decocting is used as medicine, and the active component that complete reservation is medicinal is guaranteed clinical efficacy more.
Embodiment 1
Endothelium Corneum Gigeriae Galli 170g is ground into fine powder, and Fructus Crataegi (parched to brown) 425g, Fructus Hordei Germinatus 425g, Pericarpium Citri Reticulatae 170g, Radix Pseudostellariae 170g, Rhizoma Dioscoreae (parched with bran) 255g, Semen Raphani 85g decoct with water secondary, each 2 hours, add for the first time 12 times of water gagings, add 8 times of water gagings, collecting decoction for the second time, filter, filtrate decompression is concentrated into the thick paste shape, and 70 ℃ of vacuum dryings become dry extract, pulverize, add Endothelium Corneum Gigeriae Galli fine powder and suitable amount of sucrose, dextrin, mixing is made granule, drying is made 1000g.Child administration, each 2g, every day 3 times.
Embodiment 2
Endothelium Corneum Gigeriae Galli 170g is ground into fine powder, and Fructus Crataegi (parched to brown) 510g, Fructus Hordei Germinatus 425g, Pericarpium Citri Reticulatae 85g, Radix Pseudostellariae 85g, Rhizoma Dioscoreae (parched with bran) 255g, Semen Raphani 170g decoct with water secondary, each 2 hours, add for the first time 10 times of water gagings, add 10 times of water gagings, collecting decoction for the second time, filter, filtrate decompression is concentrated into the thick paste shape, 70 ℃ of thousands of extractum of vacuum drying, pulverize, add Endothelium Corneum Gigeriae Galli fine powder and suitable amount of sucrose, dextrin, mixing, make granule, drying is made 1000g, promptly.Child administration, each 2g, every day 3 times.
Embodiment 3
Endothelium Corneum Gigeriae Galli 266.7g is ground into fine powder, and Fructus Crataegi (parched to brown) 333.3g, Fructus Hordei Germinatus 333.3g, Pericarpium Citri Reticulatae 166.7g, Radix Pseudostellariae 166.7g, Rhizoma Dioscoreae (parched with bran) 266.7g, Semen Raphani 166.7g decoct with water secondary, each 2 hours, add for the first time 10 times of water gagings, add 8 times of water gagings, collecting decoction for the second time, filter, filtrate decompression is concentrated into the thick paste shape, and 70 ℃ of vacuum dryings become dry extract, pulverize, add Endothelium Corneum Gigeriae Galli fine powder and suitable amount of sucrose, dextrin, mixing, make granule, drying is made 1000g, promptly.Child administration, each 2g, every day 3 times.
Embodiment 4
Endothelium Corneum Gigeriae Galli 340g is ground into fine powder, and Fructus Crataegi (parched to brown) 255g, Fructus Hordei Germinatus 255g, Pericarpium Citri Reticulatae 255g, Radix Pseudostellariae 255g, Rhizoma Dioscoreae (parched with bran) 170g, Semen Raphani 170g decoct with water secondary, each 2 hours, add for the first time 10 times of water gagings, add 8 times of water gagings, collecting decoction for the second time, filter, filtrate decompression is concentrated into the thick paste shape, and 70 ℃ of vacuum dryings become dry extract, pulverize, add Endothelium Corneum Gigeriae Galli fine powder and suitable amount of sucrose, dextrin, mixing, make granule, drying is made 1000g, promptly.Child administration, each 2g, every day 3 times.
The pharmacodynamics data:
1. experiment title: drug extract of the present invention is to reserpine model of spleen deficiency animal appetite, body weight, serum Zn, gastrin, organizational structure, intestinal absorption, bowel movement, the influence of stress ability
2. material
2.1 medicine and grouping
Be subjected to the reagent thing: drug extract of the present invention adds Endothelium Corneum Gigeriae Galli powder by embodiment 3 preparations as for extractum and forms, and does not contain adjuvant.Children's's consumption 3g dry extract/30kg body weight/day.Three dosage group: 1.1g, 0.55g, 0.275g dry extract/kg are established in test; Be equivalent to 10,5,2.5 times of clinical consumption every day respectively.Compound method: get the former extractum 33g of drug extract of the present invention, adding distil water 300ml, mixing promptly get 100% medicinal liquid for heavy dose of usefulness, be diluted in proportion 50% and 25% medicinal liquid in dosage and low dose of use.
The positive control medicine: XIAOSHI JIANER TANGJIANG cures mainly infantile chronic diarrhea, inappetence and muscular dystrophy.Day clothes dosage is 1ml/kg, and dosage is 10ml/kg (is equivalent to clinical day clothes dosage 10 times) during test, gets former extractum administration.
Other drug: reserpine injection, specification: 1mg/ml.D-xylose test kit.The gastrin radioimmunological kit.The D-xylose.
2.2 animal
The SD rat, male, body weight 70～80g;
The SD rat, male, body weight 180～240g;
Kunming mice, male, body weight 20 ± 2g.
2.3 instrument
Sai Duolisi BS124S electronic balance, Germany; UNICO WFZ UV-2102C ultraviolet-visible spectrophotometer, sino-america joint-venture; The 180-80 of Hitachi type polarization Zeeman atomic absorption spectrophotometer (AAS), Japan; γ-radiation numeration instrument, China; Olympus CX41 system biological microscope, Japan; Come card RM2016 cycle type microtome, Germany; Come card TP1020 type Automation-tissue-dehydrating machine, Germany; PHY-III type pathological tissue floats baking instrument, China; Middle prestige BMJ-III type embedding machine, China.
3. method
3.1 drug extract of the present invention is to the influence of reserpine model of spleen deficiency rat appetite, body weight
Get 72 of body weight 75 ± 5g rats, male, be divided into normal group, model group, positive controls, the large, medium and small dosage group of drug extract of the present invention at random, 12 every group.Single cage is raised, irritate stomach distilled water (normal group and model group) respectively by group, XIAOSHI JIANER TANGJIANG, 100% drug extract medicinal liquid of the present invention, 50% drug extract medicinal liquid of the present invention, 25% drug extract medicinal liquid 10ml/ of the present invention (kgd), while normal group intraperitoneal injection of saline 2ml/kg, all the other respectively organize every rats by intraperitoneal injection 0.3mg/kg reserpine, continuous modeling 21d, write down food-intake and body weight every day, and observe rat gross morphology and symptom, calculate and respectively organize the 7th, 14,21 days body weight and preceding 7 days, middle 7 days, the means standard deviation of the 7 days food-intakes in back.
Data computation mean ± standard deviation adopts one factor analysis of variance, carries out statistical disposition with SPSS11.5.
3.2 the influence that drug extract of the present invention absorbs reserpine model of spleen deficiency rat D-xylose
Get 72 of body weight 220 ± 20g rats, male, be divided into normal group, model group, positive controls, the large, medium and small dosage group of drug extract of the present invention at random, 12 every group.Irritate stomach distilled water (normal group and model group), XIAOSHI JIANER TANGJIANG, 100% drug extract medicinal liquid of the present invention, 50% drug extract medicinal liquid of the present invention, 25% drug extract medicinal liquid 10ml/ of the present invention (kgd) respectively by group, while normal group intraperitoneal injection of saline 2ml/kg, all the other respectively organize every rats by intraperitoneal injection 0.3mg/kg reserpine, continuously modeling 21d.
The reserpine modeling, reach 21d after the drug extract of the present invention treatment after, 21d begins fasting and can't help water 8 o'clock evening, irritates stomach behind the 12h and only gives 5% D-xylose solution 2ml/.Behind the 1h punctio vesicae is got urine, measures the urine xylose according to the test kit description, with spectrophotometer in 554nm place colorimetric.Data computation mean ± standard deviation adopts one factor analysis of variance, carries out statistical disposition with SPSS11.5.
3.3 drug extract of the present invention is to the influence of rats'swimming time of reserpine model of spleen deficiency
Get 72 of body weight 200 ± 20g rats, male, be divided into normal group, model group, positive controls, the large, medium and small dosage group of drug extract of the present invention at random, 12 every group.Irritate stomach distilled water (normal group and model group), XIAOSHI JIANER TANGJIANG, 100% drug extract medicinal liquid of the present invention, 50% drug extract medicinal liquid of the present invention, 25% drug extract medicinal liquid 10ml/ of the present invention (kgd) respectively by group, while normal group intraperitoneal injection of saline 2ml/kg, all the other respectively organize every rats by intraperitoneal injection 0.3mg/kg reserpine, continuously modeling 21d.
1 hour weight after the last administration in rat tails bundle one body weight 10%, and with it put into add the waterglass cylinder (100 * 50 * 60cm) swimming, the depth of water is 60cm, water temperature is 20 ± 0.5 ℃, and timing immediately, when 20 seconds of rat head submerged can not the person of emerging be that body is that power exhausts that timing immediately is the rats'swimming time.Calculate the means standard deviation of respectively organizing the rats'swimming time.Data computation mean ± standard deviation adopts one factor analysis of variance, carries out statistical disposition with SPSS11.5.
3.4 drug extract of the present invention is to the propulsive influence of reserpine model of spleen deficiency mice intestinal
Get 72 of body weight 20 ± 2g mices, male, be divided into normal group, model group, positive controls, the large, medium and small dosage group of drug extract of the present invention at random, 12 every group.Irritate stomach distilled water (normal group and model group), XIAOSHI JIANER TANGJIANG, 100% drug extract medicinal liquid of the present invention, 50% drug extract medicinal liquid of the present invention, 25% drug extract medicinal liquid 10ml/ of the present invention (kgd) respectively by group, while normal group intraperitoneal injection of saline 2ml/kg, all the other respectively organize every rats by intraperitoneal injection 0.3mg/kg reserpine, continuously modeling 7d.
After the last administration, water 12h is can't help in the mice fasting before the experiment, handles administration 1 time again on the same day, 1.5h behind medicine, and every Mus is irritated the carbon ink suspension (sodium carboxymethyl cellulose with 1% is prepared) of stomach 5%, 0.1ml/10g body weight.Behind the 15min, mice takes off cervical vertebra puts to death, and cuts open the belly immediately and takes out the small intestinal total length, and record carbon powder forward position is to the distance of pylorus; Calculating accounts for the percentage ratio of small intestinal total length.Charcoal end propelling rate (%)=advance distance/small intestinal total length * 100% of charcoal end in small intestinal.Calculate the means standard deviation of respectively organizing charcoal end propelling rate.Data computation mean ± standard deviation adopts one factor analysis of variance, carries out statistical disposition with SPSS11.5.
4 results
4.1 drug extract of the present invention is to the influence of reserpine model of spleen deficiency rat appetite, body weight
The appetite of reserpine model of spleen deficiency treated animal reduces, and body weight gain is slow, compares with the blank group, and utmost point significant difference is arranged.After drug extract medicinal liquid treatment of the present invention, the appetite of large, medium and small dosage group was recovered after 7 days gradually, and body weight gain is accelerated, and compared with model group, and significance and utmost point significant difference are arranged.The results are shown in Table 1, table 2.
Table 1 drug extract of the present invention to reserpine model of spleen deficiency rat appetite,
Influence (x ± s, n=12)
Annotate: compare * P＜0.05 with normal group, #P＜0.05, ##P＜0.01 are compared with model group in * * P＜0.01.
4.2 the influence that drug extract of the present invention absorbs reserpine model of spleen deficiency rat D-xylose
The D-xylose of reserpine model of spleen deficiency treated animal absorbs slowly, compares with the blank group, and utmost point significant difference is arranged.After drug extract medicinal liquid of the present invention treatment, in, the D-xylose absorbability of heavy dose of group accelerates, and has certain dosage to rely on trend, with model group relatively, significant difference is arranged.The results are shown in Table 3.
Table 3 drug extract of the present invention is to reserpine model of spleen deficiency rat D-xylose
Influence (x ± s, n=12)
Annotate: compare * P＜0.05 with normal group, #P＜0.05, ##P＜0.01 are compared with model group in * * P＜0.01.
4.3 drug extract of the present invention is to the influence of rats'swimming time of reserpine model of spleen deficiency
The swimming time of reserpine model of spleen deficiency treated animal reduces, and compares with the blank group, and utmost point significant difference is arranged.After drug extract medicinal liquid of the present invention treatment, little, in, the swimming time of heavy dose of group increases, with model group relatively, utmost point significant difference is arranged.The results are shown in Table 4.
Table 4 drug extract of the present invention is during to reserpine model of spleen deficiency rats'swimming
Influence (x ± s, n=12)
Annotate: compare * P＜0.05 with normal group, #P＜0.05, ##P＜0.01 are compared with model group in * * P＜0.01.
4.4 drug extract of the present invention is to the propulsive influence of reserpine model of spleen deficiency mice intestinal
The carbon powder propelling rate of reserpine model of spleen deficiency treated animal increases, and intestinal propulsion is accelerated, and compares with the blank group, and utmost point significant difference is arranged.After drug extract medicinal liquid of the present invention treatment, little, in, the carbon powder propelling rate of heavy dose of group reduces gradually, intestinal propulsion speed slows down, with model group relatively, significant difference is arranged.The results are shown in Table 5.
Table 5 drug extract of the present invention to the propulsive influence of reserpine model of spleen deficiency mice intestinal (x ± s, n=12)
Annotate: compare * P＜0.05 with normal group, #P＜0.05, ##P＜0.01 are compared with model group in * * P＜0.01.
5 conclusions
Drug extract of the present invention can obviously increase appetite and the body weight of reserpine model of spleen deficiency rat, can improve reserpine model of spleen deficiency rat small intestine absorption function, increases the D-xylose and absorbs.Endurance to reserpine model of spleen deficiency rat has potentiation equally, increases swimming time.Reserpine model of spleen deficiency mice intestine movement function there is the effect of slowing down, reduces mice intestinal carbon powder and advance.
Results suggest, drug extract of the present invention can be resisted the effect that model of spleen deficiency animal appetite is poor, body weight gain slowly reaches the endurance difference.And the gastrointestinal motility function had the two-phase regulating action, promote the absorption of stomachial secretion function and small intestinal to nutrient substance.
Claims (6)
1. medicine for the treatment of infantile anorexia is characterized in that it is made by following bulk drugs: Fructus Crataegi (parched to brown) 10-30%, Fructus Hordei Germinatus 10-30%, Endothelium Corneum Gigeriae Galli 10-25%, Pericarpium Citri Reticulatae 5-15%, Radix Pseudostellariae 5-15%, Rhizoma Dioscoreae (parched with bran) 10-25%, Semen Raphani 5-15%.
2. the medicine of treatment infantile anorexia according to claim 1 is characterized in that it is made by following bulk drugs: Fructus Crataegi (parched to brown) 15-25%, Fructus Hordei Germinatus 15-25%, Endothelium Corneum Gigeriae Galli 15-20%, Pericarpium Citri Reticulatae 5-10%, Radix Pseudostellariae 5-10%, Rhizoma Dioscoreae (parched with bran) 15-20%, Semen Raphani 5-10%.
3. the medicine of treatment infantile anorexia according to claim 2 is characterized in that it is made by following bulk drugs: Fructus Crataegi (parched to brown) 19-20%, Fructus Hordei Germinatus 19-20%, Endothelium Corneum Gigeriae Galli 15-16%, Pericarpium Citri Reticulatae 9-10%, Radix Pseudostellariae 9-10%, Rhizoma Dioscoreae (parched with bran) 15-16%, Semen Raphani 9-10%.
4. the preparation method of claim 1 or 2 or 3 described medicines is characterized by: take by weighing medical material except that Endothelium Corneum Gigeriae Galli in extraction pot, carry after drying through conventional water, make dry extract and be ground into fine powder; Add the Endothelium Corneum Gigeriae Galli fine powder again, mix homogeneously is promptly made the active component of medicine of the present invention.
5. the preparation method of the described medicine of claim 4 is characterized in that active component can add adjuvant, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine.
6. the preparation method of the described medicine of claim 5 is characterized in that active component adds sucrose, dextrin, and mixing is made granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100278012A CN1895575B (en) | 2006-06-19 | 2006-06-19 | Medicine for treating infantile anorexia and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100278012A CN1895575B (en) | 2006-06-19 | 2006-06-19 | Medicine for treating infantile anorexia and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1895575A CN1895575A (en) | 2007-01-17 |
| CN1895575B true CN1895575B (en) | 2010-06-09 |
Family
ID=37608316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100278012A Active CN1895575B (en) | 2006-06-19 | 2006-06-19 | Medicine for treating infantile anorexia and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1895575B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850081B (en) * | 2009-03-31 | 2013-12-11 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition capable of facilitating digestion and preparation method thereof |
| CN102380061B (en) * | 2011-07-19 | 2018-06-22 | 张玮偲 | A kind of eliminating the phlegm, dissolving phlegm, the Chinese medicine composition of cough-relieving and preparation method and application |
| CN103191332A (en) * | 2012-01-04 | 2013-07-10 | 安琪酵母股份有限公司 | Composition and health-care product with stomach-invigorating and digestion-promoting functions |
| CN103055209B (en) * | 2013-01-08 | 2015-02-04 | 洛阳本草生物制药股份有限公司 | Appetizing chewing tablet and its preparation technology |
| CN103142807A (en) * | 2013-03-08 | 2013-06-12 | 潘恩山 | Spleen arousing and children strong-keeping soup and preparation method thereof |
| CN104137928A (en) * | 2013-05-11 | 2014-11-12 | 陈冠卿 | Appetite stimulating and digestion helping tea |
| CN104273276A (en) * | 2013-07-04 | 2015-01-14 | 陈冠卿 | Green tea capable of stimulating appetite and digestion |
| CN103783513B (en) * | 2013-12-31 | 2016-04-13 | 陈慧婷 | A kind of radish seed Chinese yam dispersible tablet and preparation method |
| CN105434999A (en) * | 2015-12-14 | 2016-03-30 | 张翠华 | Preparation for treating infantile apocleisis and preparation method thereof |
| CN113016714B (en) * | 2021-03-04 | 2023-08-22 | 湖南中医药大学 | Preparation method of animal model with diarrhea and food stagnation gastrointestinal symptoms |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125050A (en) * | 1994-12-21 | 1996-06-26 | 薛琳 | Method for preparing feierbing cracker |
| CN1519006A (en) * | 2003-01-21 | 2004-08-11 | 贵州本草堂药业有限公司 | Prepared Chinese medicine for treating fastidium of wean caused by deficient spleen and food stasis |
-
2006
- 2006-06-19 CN CN2006100278012A patent/CN1895575B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125050A (en) * | 1994-12-21 | 1996-06-26 | 薛琳 | Method for preparing feierbing cracker |
| CN1519006A (en) * | 2003-01-21 | 2004-08-11 | 贵州本草堂药业有限公司 | Prepared Chinese medicine for treating fastidium of wean caused by deficient spleen and food stasis |
Non-Patent Citations (2)
| Title |
|---|
| 赵桂英等.厌食冲剂的制备及临床观察.山东医药工业20 1.2001,20(1),42-43. |
| 赵桂英等.厌食冲剂的制备及临床观察.山东医药工业20 1.2001,20(1),42-43. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1895575A (en) | 2007-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1895575B (en) | Medicine for treating infantile anorexia and its preparation | |
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN104435775A (en) | Chinese medicinal health-care spirit and preparation method thereof | |
| CN103053748A (en) | Kudzu vine root fat-reducing sugar-reducing health-care tea and preparation method thereof | |
| CN106666638A (en) | Tartary buckwheat medicated salt and preparation method thereof | |
| CN106039187A (en) | Child Shi-kang tea and preparation method thereof | |
| CN104856059A (en) | Weight-losing health nutrition powder | |
| CN103005559A (en) | Spleen tonifying and appetite promoting drink and preparation method thereof | |
| CN104958646A (en) | Chinese medicinal preparation for relaxing bowels and preparation method thereof | |
| CN104905267A (en) | Semen cassiae health oral liquid capable of decreasing blood lipid and preparation method thereof | |
| CN109847027A (en) | A kind of preparation process of Guben Huatan Chinese traditional medicines depressing lipid composition and its preparation | |
| CN109315666A (en) | Diet therapy nutritional element solid beverage and preparation method thereof for nephrosis | |
| CN103355444B (en) | A kind of invigorating the spleen qi-tonifying health-care tea cream and preparation method | |
| CN105623995B (en) | Large-fruited Chinese hawthorn aperitif and beverage and preparation method thereof | |
| CN104857238A (en) | Traditional Chinese medicine for treating spleen-kidney-yang deficiency type iron-deficiency anemia and preparation method | |
| CN106107243A (en) | A kind of feed additive for improving Macrobrachium nipponensis(de Haan) meat and local flavor and preparation method thereof | |
| CN105343593A (en) | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid | |
| CN104397282A (en) | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof | |
| KR101783549B1 (en) | Health supplement food containing dha for recovering fatigue, and method of manufacturing the same | |
| CN105533749B (en) | It is a kind of containing Herba Epimedii, the health food of Schisandra chinensis and its preparation method and application | |
| CN103725587A (en) | Sealwort and hawthorn vinegar and production method thereof | |
| CN106692845A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN105327261A (en) | Semen raphani traditional Chinese medicine combination capable of nourishing stomach and preparation method thereof | |
| CN109567196A (en) | A kind of food and preparation method thereof alleviated dysmenorrhea and nourish vigour | |
| CN108671076A (en) | A kind of drug and preparation method thereof for treating alpastic anemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SUZHOU YOUSEEN NEW MEDICINE EXPLOITATION CO., LTD. Free format text: FORMER OWNER: SHANGHAI YOUSEEN NEW MEDICINE EXPLOITATION CO., LTD. Effective date: 20121220 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201203 PUDONG NEW AREA, SHANGHAI TO: 215123 SUZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121220 Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 bio Nano Technology Park building 218 C30 Patentee after: SUZHOU YOUSEEN NEW DRUG R & D Co.,Ltd. Address before: 201203 Shanghai Guo Shou Jing Road, Pudong New Area Zhangjiang hi tech Park No. 351 Patentee before: SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200117 Address after: Tianhe District Tianshou road Guangzhou City, Guangdong province 510610 31 1701 01 real self Patentee after: Guangdong Aimin Pharmaceutical Co.,Ltd. Address before: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 bio Nano Technology Park building 218 C30 Patentee before: SUZHOU YOUSEEN NEW DRUG R & D Co.,Ltd. |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20200228 Address after: Tianhe District Tianshou road Guangzhou City, Guangdong province 510610 31 1701 01 real self Patentee after: Guangdong Aimin Pharmaceutical Co.,Ltd. Address before: 201203 Room 401, building 2, No. 351, GuoShouJing Road, China (Shanghai) pilot Free Trade Zone, Shanghai Patentee before: SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION Co.,Ltd. Effective date of registration: 20200228 Address after: 201203 Room 401, building 2, No. 351, GuoShouJing Road, China (Shanghai) pilot Free Trade Zone, Shanghai Patentee after: SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION Co.,Ltd. Address before: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215123 bio Nano Technology Park building 218 C30 Patentee before: SUZHOU YOUSEEN NEW DRUG R & D Co.,Ltd. |
|
| TR01 | Transfer of patent right |