CN104127758A - Traditional Chinese medicinal composition having spleen invigorating and stomach nourishing efficacies, and preparation method and application thereof - Google Patents
Traditional Chinese medicinal composition having spleen invigorating and stomach nourishing efficacies, and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition having spleen invigorating and stomach nourishing efficacies, and a preparation method and an application thereof. Effective components of the traditional Chinese medicinal composition are prepared by using the following raw materials, by weight, 2-40 parts of Dendrobium officinale, 1-40 parts of Chinese yam, 2-40 parts of Hippophae rhamnoides, 2-40 parts of hawthorn fruit, 2-40 parts of stir-fried malt, 2-40 parts of chicken's gizzard membrane and 2-40 parts of radish seed. The traditional Chinese medicinal composition has substantial spleen invigorating and stomach nourishing efficacies, and can substantially improve inappetence, dyspepsia and chest and abdomen fullness of spleen and stomach disease patients.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect and its preparation method and application.
Background technology
Taste person, the foundation of acquired constitution, controls central authorities, transporting the nutrient-fluids to various parts of the body, skin blood vessels are rely invariably in this.Although the epoch substitute from ancient times to the present, folk custom also changes, and spectrum of disease changes more to some extent, no matter prevents, treats the conditioning that diseases caused by exogenous pathogenic factor and internal injury disease need to focus on taste invariably.Along with social progress and development, people's living standard improves constantly, dietary structure unreasonable.The thick greasy food of delicious food is taken in a large number, be difficult to digest and assimilate, moreover bad living habit and feelings will illness the reason such as increase, easily cause the disease of digestive system, show as breast abdomen vexed swollen, stomachache flatulence, dyspepsia, inappetence, feel sick, belch, constipation or diarrhoea, cause people painful greatly.Treat clinically gastropathy comparatively thorny, often take and support as main, general treatment is temporary pain relieving, does not reach the object for the treatment of.
Summary of the invention
Based on this, the object of the present invention is to provide a kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect.
The concrete technical scheme solving the problems of the technologies described above is as follows:
A Chinese medicine composition with strengthening the spleen and nourishing the stomach effect, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts:
Herba Dendrobii 2-40 part, Rhizoma Dioscoreae 1-40 part, Fructus Hippophae 2-40 part, Fructus Crataegi 2-40 part, Fructus Hordei Germinatus (parched) 2-40 part, Endothelium Corneum Gigeriae Galli 2-40 part, Semen Raphani 2-40 part.
In some embodiment, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts therein:
Herba Dendrobii 2-20 part, Rhizoma Dioscoreae 2-20 part, Fructus Hippophae 3-30 part, Fructus Crataegi 2-30 part, Fructus Hordei Germinatus (parched) 2-30 part, Endothelium Corneum Gigeriae Galli 3-40 part, Semen Raphani 3-30 part.
In some embodiment, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts therein:
Herba Dendrobii 2-12 part, Rhizoma Dioscoreae 2-10 part, Fructus Hippophae 3-15 part, Fructus Crataegi 2-14 part, Fructus Hordei Germinatus (parched) 2-14 part, Endothelium Corneum Gigeriae Galli 3-20 part, Semen Raphani 3-15 part.
In some embodiment, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts therein:
Herba Dendrobii 3-5 part, Rhizoma Dioscoreae 5-7 part, Fructus Hippophae 5-7 part, Fructus Crataegi 5-7 part, Fructus Hordei Germinatus (parched) 5-7 part, Endothelium Corneum Gigeriae Galli 7-9 part, Semen Raphani 5-7 part.
Another object of the present invention is to provide a kind of above-mentioned preparation method with the Chinese medicine composition of strengthening the spleen and nourishing the stomach effect, comprise the steps:
Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani are cured under 60-80 ℃ of condition, remove part moisture, separately or co-grinding (breaking method can be that standard machinery was pulverized 200 mesh sieves, also can be crushed to micronization with super micron mill), add acceptable adjuvant on medicine or on health food, mix and make regular dosage form;
Or Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani are cured under 60-80 ℃ of condition, remove part moisture, separately or co-grinding (breaking method can be that standard machinery was pulverized 200 mesh sieves, also can be crushed to micronization with super micron mill), water and/or ethanol extract, filter, obtain filtrate, after filtrate is concentrated, add acceptable adjuvant on medicine or on health food, mix and make regular dosage form;
Or incite somebody to action or Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani merging, extracting in water, filters, and obtains filtrate, adds acceptable adjuvant on medicine or on health food, mixes and make regular dosage form.
In some embodiment, the method for described extraction is water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method therein.
Another object of the present invention is to provide above-mentioned Chinese medicine composition to there is the application in the medicine of strengthening the spleen and nourishing the stomach effect in preparation.
In some embodiment, the dosage form of described medicine is therein: tablet, capsule, pill, granule, powder, oral liquid, decoction or unguentum.
The pharmacology of the Chinese medicine composition with strengthening the spleen and nourishing the stomach of the present invention is as follows:
Raw material in Chinese medicine composition of the present invention, outside removing iron sheet Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Semen Raphani are all the Chinese crude drugs of integration of edible and medicinal herbs.
Wherein, Herba Dendrobii (Dendrobium officinale) is the orchid family Dendrobium herbaceos perennial, belong to Chinese medicine material, applicating history is long, pharmacological effect is remarkable, in the clinical practice of Chinese medicine of thousands of years, be verified, it is the famous and precious medicinal plants of YIN nourishing tonification, the < < Sheng Nong's herbal classic > > of the Eastern Han Dynasty is classified as top grade, there is main damaging the spleen and stomach, except fraud, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia is thin and weak, reinforcing YIN-essence, take for a long time the effects such as thick the intestines and stomach, can play to a certain extent the effect of function of spleen and stomach regulating.
Rhizoma Dioscoreae spleen reinforcing nourishing the stomach in this formula, the lung benefiting that promotes the production of body fluid is monarch drug, insufficiency of the spleen lack of appetite, the loose stool of having loose bowels is aided with Fructus Hippophae, Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion; Reuse the sweet tepor of Crataegolic acid, kind carnivorous greasy the amassing that disappear; The pungent sweet therapeutic method to keep the adverse QI flowing downwards of Semen Raphani, is longer than the wheaten food that disappears long-pending, free from worry chest and diaphragm, and relieving distension is except full; The sweet parallel air of Fructus Hordei Germinatus (parched) helps digestion, spleen benefiting and stimulating the appetite, and it is adjuvant drug altogether that above three medicines (Fructus Crataegi, Semen Raphani and Fructus Hordei Germinatus (parched)) share, the various eating accumulations that can disappear, and energy invigorating the spleen and regulating the stomach; Herba Dendrobii is sweet cold, grows the moon of lung stomach, can help the main digesting food of stomach, changes the raw qi-blood-body fluid of spermatogenesis macro, supports whole body, again can coordinating the actions of various ingredients in a prescription, make full side's tonify without causing stagnation, and temperature and not dry, receives the merit that spleen benefiting and stimulating the appetite helps digestion altogether.
Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present invention and its preparation method and application has the following advantages and beneficial effect:
(1) the present invention, through inventor's great many of experiments and research, draws optimum feed stock and the proportioning of the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect, and this Chinese medicine composition can significantly improve the vexed swollen symptom of the spleen-stomach disease patient inappetence, dyspepsia and breast abdomen.
(2) preparation method of the present invention, simple to operation.
The specific embodiment
Because state's laws provide against, use rare wildlife and plants productions of being used as medicine, Herba Dendrobii of the present invention can be bred with pseudo-wild cultivating acquisition or directly be purchased available Herba Dendrobii by the training of conventional method group; Each crude drug of used other all can be bought and obtain at pharmacy.
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 4g, Rhizoma Dioscoreae 6g, Fructus Hippophae 6g, Fructus Crataegi 6g, Fructus Hordei Germinatus (parched) 6g, Endothelium Corneum Gigeriae Galli 8g, Semen Raphani 6g.
The granule being made by above-mentioned Chinese medicine composition, its raw material by following weight is prepared from:
Major ingredient: above-mentioned Chinese medicine composition;
Adjuvant: Mel 10g, sucrose 2g.
The preparation method of above-mentioned granule, comprises the steps:
(1) respectively Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli are carried out to low temperature (60 ℃-80 ℃) and cure, remove the part moisture in raw material, mix or be ground into separately coarse powder, mix, obtain mixture;
(2) Semen Raphani low temperature (60 ℃-80 ℃) is cured, remove the part moisture in raw material, join in step (1) gained mixture, pulverize, cross 200 mesh sieves, mix;
(3) by sucrose drying and crushing at 60 ℃ of-80 ℃ of temperature, and cross 80 mesh sieves, standby;
(3) get the micropowder that step (2) makes and mix homogeneously with step (3) sucrose powder, spraying adds the ethanol that is equivalent to mixed material weight 5%, granulates, dry, 20 order granulate, obtains granule.
Embodiment 2
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 2g, Rhizoma Dioscoreae 10g, Fructus Hippophae 8g, Fructus Crataegi 5g, Fructus Hordei Germinatus (parched) 3g, Endothelium Corneum Gigeriae Galli 3g, Semen Raphani 6g.
The compound recipe unguentum being made by above-mentioned Chinese medicine composition, its raw material by following weight is prepared from:
Major ingredient: above-mentioned Chinese medicine composition;
Adjuvant: Mel 10g, sucrose 2g.
The preparation method of above-mentioned compound recipe unguentum comprises the steps:
(1) by above-mentioned each raw material pulverize at low temperature, cross 200 mesh sieves, obtain medicated powder;
(2) in the medicated powder of step (1) gained, add the water of 8 times of amounts, lixiviate 2 hours, filters, and obtains extracting solution; In filtering residue, add the water of 6 times of amounts, lixiviate 1.5 hours, filters merge extractive liquid, again; It is 1.45 extractum that extracting solution is evaporated to relative proportion, standby;
(3) in the extractum of step (2) gained, add Mel and sucrose, stir and make mix homogeneously, heating is concentrated into relative proportion 1.50 extractum, and sterilizing, canned, packing, obtain unguentum.
Embodiment 3
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 5g, Rhizoma Dioscoreae 8g, Fructus Hippophae 8g, Fructus Crataegi 8g, Fructus Hordei Germinatus (parched) 8g, Endothelium Corneum Gigeriae Galli 6g, Semen Raphani 8g.
The decoction being made by above-mentioned Chinese medicine composition, it is prepared from by above-mentioned Chinese medicine composition, and the preparation method of described decoction, comprises the steps:
Take above-mentioned each material, be mixed to get mixture, in mixture, add the water of 8 times of amounts, soak after half an hour, be heated to boil, decoct extracting juice 1 hour; In filtering residue, add again the water of 6 times of amounts, be heated to boil, decoct half an hour, extracting juice; Merge medicine juice twice, stir, obtain decoction.
Embodiment 4
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 4g, Rhizoma Dioscoreae 5g, Fructus Hippophae 6g, Fructus Crataegi 6g, Fructus Hordei Germinatus (parched) 6g, Endothelium Corneum Gigeriae Galli 6g, Semen Raphani 6g.
The compound capsule being made by above-mentioned Chinese medicine composition, its raw material by following weight is prepared from:
Major ingredient: above-mentioned Chinese medicine composition;
Adjuvant: Pulvis Talci 0.3g, magnesium stearate 0.2g.
The preparation method of above-mentioned compound capsule, comprises the steps:
(1) Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli are carried out to low temperature and cure, remove the part moisture in raw material, mixed powder is broken into coarse powder, obtains mixture A;
(2) Semen Raphani is joined in the mixture A of step (1) gained, pulverize, mix homogeneously, crosses 200 mesh sieves, obtains mixture B;
(3) in the mixture B of step (2) gained, add adjuvant (Pulvis Talci 0.3g, magnesium stearate 0.2g) mix homogeneously, filling capsule, packing, obtains capsule.
Embodiment 5
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 12g, Rhizoma Dioscoreae 9g, Fructus Hippophae 15g, Fructus Crataegi 14g, Fructus Hordei Germinatus (parched) 14g, Endothelium Corneum Gigeriae Galli 20g, Semen Raphani 15g.
The pill being made by above-mentioned Chinese medicine composition, its raw material by following weight is prepared from:
Major ingredient: above-mentioned Chinese medicine composition;
Adjuvant: water 50mL and Mel 10g.
The preparation method of above-mentioned pill, comprises the steps:
(1) just Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli carry out low temperature and cure, and after remove portion moisture, are ground into medicated powder;
(2) 60～80 ℃ of Semen Raphanis are cured, after remove portion moisture, join in step (1) gained medicated powder, mix homogeneously, progressively pulverizes, and crosses 80 mesh sieves, obtains mixed powder;
(3) in the described mixed powder of step (2), add water 80mL and Mel 30g, soft material processed, pill, dry, select ball, capping, obtains described pill.
Embodiment 6
A kind of Chinese medicine composition with strengthening the spleen and nourishing the stomach effect of the present embodiment, its effective ingredient is mainly prepared from by the raw material of following weight:
Herba Dendrobii 20g, Rhizoma Dioscoreae 20g, Fructus Hippophae 30g, Fructus Crataegi 29g, Fructus Hordei Germinatus (parched) 29g, Endothelium Corneum Gigeriae Galli 39g, Semen Raphani 30g.
The oral liquid being made by above-mentioned Chinese medicine composition, its raw material by following weight is prepared from:
Major ingredient: above-mentioned Chinese medicine composition;
Adjuvant: sodium benzoate 20g and sucrose 8g.
The preparation method of above-mentioned oral liquid, comprises the steps:
(1) Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli, Semen Raphani merge, and add the water of 8 times of weight, soak 0.5h, are heated to boiling, decoct 1h, filter, and obtain filtering residue and extracting solution;
(2) in described filtering residue, add again the water of 6 times of weight, be heated to boiling, decoct 0.5h, filter to obtain extracting solution;
(3) combining step (1) and (2) described extracting solution, stir, and removes precipitation or not tolerant, is concentrated into 1900～2000ml, adds sodium benzoate 20g and sucrose 8g to carry out dosing, obtains described oral liquid.
Test example 1 safety toxicology test
One, experiment purpose
Take embodiment 1 as example, evaluate the safety of formula of the present invention.
Two, experimental technique
The prepared brown granule of laboratory sample and character: embodiment 1, is modulated into each concentration by it with distilled water, for examination.
Laboratory animal: Kunming kind white mice (being provided by drug research institute of Central South University animal center receptacle) is provided, is carried out acute toxicity test, adopt three methods such as MTT cytotoxicity experiment, micronucleus test and Ames experiment to detect its mutagenesis type.Meanwhile, do Wistar rat (being provided by drug research institute of Central South University animal center receptacle) 30d feeding trial, specific as follows:
1.1 acute toxicity testing
With acute toxicity half lethal dose toxicity grading.
1.2MTT cytotoxicity experiment
Adopt tetrazolium bromide (MTT) method to carry out cytotoxicity analysis to the present embodiment 1 granule, experiment in triplicate.
1.3 micronucleus test
The test of sample Micronucleus.
1.4Ames (Salmonella typhimurium back mutation experiment) experiment
1.5 long term toxicity tests:
This experiment is divided into experimental group and matched group, and wherein, experimental group is the prepared granule low dose group of embodiment 1 10g/kg, middle dosage group 20g/kg, 40 groups of g/kg of high dose, is equivalent to respectively 12.5 times, 25 times and 50 times of clinical adult dose for oral use, matched group is normal group, by Wistar rat, divide four groups at random, every group 10, male and female half and half, by the dosage design of above-mentioned group once a day, feed continuously after 30 days, observe growth of animal situation and body weight and dirty body ratio, and carry out hematological examination and (mainly detect RBC (red blood cell count(RBC)), PLT (platelet count), WBC (numeration of leukocyte) and Hb (hemoglobinometry)), blood biochemical is learned inspection and (is mainly detected glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), total serum protein (TP), serum albumin (ALB), blood urea nitrogen (BUN), creatinine (CRE), blood glucose (GLU), cholesterol (TC), serum triglycerides (TG)).
Three, experimental result
3.1 acute toxicity testing results
This product is not measured LD
50(half lethal dose), mice maximum tolerated dose is 200g/kg/ day, Continuous Observation seven days, 20 mices all survive, and do not occur abnormal response.The present embodiment 1 granule is 600 times for adult's oral dose every day to mouse stomach administration maximal tolerance times.
3.2MTT cytotoxicity experiment result
Do not measure LD
50(half lethal dose), ED
0(maximum no-effect dose)=1g (medicine)/10ml (culture fluid).
3.3 micronucleus test results
Sample Micronucleus result of the test is negative.
3.4Ames (Salmonella typhimurium back mutation experiment) experimental result
Experimental result is negative.
3.5 long term toxicity test results
3.5.1 growing state and body weight
Experimental result is as table 1, as known from Table 1: each experimental group and normal rats comparison, ordinary circumstance Non Apparent Abnormality (movable normal, feed is normal, growth, grow normal).Statistical analysis demonstration, the basic, normal, high dosage group of embodiment 1 Mouse Weight is compared with normal group and is not all had significant difference (p>0.05), illustrates that embodiment 1 granules of rats body weight does not make significant difference.
The impact of table 1 embodiment 1 granules of rats body weight (g, ± s)
Note: * p<0.05, relatively has significant difference with matched group; * p<0.01, relatively has utmost point significant difference with matched group.
3.5.2 dirty body ratio
1. each experimental group of finding of naked eye and the Normal group rat heart, liver, spleen, lung, kidney, stomach, intestinal are all normal.
2. each experimental group of micro-Microscopic observation and the Normal group rat heart, liver, spleen, lung, kidney, testis and ovary, be showed no abnormality;
3. Epidemiological Analysis by statistics: the dirty body of basic, normal, high dosage group is compared than with normal group, all without significant difference (p>0.05), illustrates that each dirty body of embodiment 1 granules of rats does not make significant difference.
The impact of the dirty hierarchy number of table 2 embodiment 1 granules of rats
Note: * p<0.05, relatively has significant difference with matched group; * p<0.01, relatively has utmost point significant difference with matched group.
3.5.3 hematological examination
Testing result is in Table 3, as known from Table 3: basic, normal, high dosage group routine blood test is compared with normal group, all without significant difference (p>0.05), illustrates that the prepared granules of rats routine blood test of embodiment 1 does not make significant difference.
The impact of table 3 Herba Dendrobii compound granular agent on rat serum routine
Note: * p<0.05, relatively has significant difference with matched group; * p<0.01, relatively has utmost point significant difference with matched group.
3.5.4 blood biochemistry checking
Experimental result is in Table 4, as known from Table 4: basic, normal, high dosage group blood parameters is compared with matched group, all without significant difference (p>0.05), illustrates that the prepared granule of embodiment 1 does not make significant difference to blood parameters.
The impact of table 4 Herba Dendrobii compound granular agent on rat blood biochemical indicator
Note: * p<0.05, relatively has significant difference with matched group; * p<0.01, relatively has utmost point significant difference with matched group.
Four, conclusion
The above results is known, and in this test example, laboratory animal growing state is good, hematological examination, and blood biochemical is learned and is checked, and when histological examination result of main dirty body is compared with matched group, all without significant difference, illustrates that preparation safety of the present invention is nontoxic.
Test example 2
One, experiment purpose
By relative analysis, evaluate the impact of the prepared granule of embodiment 1 on intemperance of taking food type Rats with Spleen-deficiency.
Two, experimental technique
2.1 animal
60 of SD rats, weight 180～220g, male and female half and half.Adaptability was fed after 1 week, got at random 50 rats and carried out the preparation of intemperance of taking food type rat model, and gavage refined lard every day (10mL/Kg), gives Caulis et Folium Brassicae capitatae simultaneously and feed, continuously modeling 10d.Normal rats, every day, gavage waited capacity water (10mL/Kg), normal forage feed.
2.2 GP TH
Be divided into modeling success rat is real: low (0.4g/kg), in (0.8g/kg), high (1.6g/kg) three dosage groups, model group and positive controls (domperidone 0.2g/kg), get not modeling rat as normal group.Each administration group administration every day 1 time, successive administration 14d.Every day in regular time is recorded each treated animal changes of body mass situation, and after last administration, rat fasting 24h, freely drinks water.Normal group and model group give isodose normal saline every day.
Three, experimental result
3.1 impacts of above-described embodiment 1 granule on intemperance of taking food rat weight
Result is referring to table 5, as known from Table 5: before modeling, each treated animal weight is close, and difference is remarkable (P>0.05) not.After modeling, each group of modeling compares weight with normal group and reduces extremely significantly (P < 0.01).After administration, with normal group comparison, positive controls, height, the equal difference of middle dosage group rat weight is remarkable (P>0.05) not, and model group and low dose group difference is remarkable (P < 0.01 or P < 0.05) all; Compare with model group, each treatment group weight difference is (P < 0.01) extremely significantly; Compare with positive controls, the equal difference of weight of high, middle dosage group is remarkable (P>0.05) not.
The impact of table 5 embodiment 1 granule on intemperance of taking food type Rats with Spleen-deficiency weight
Note: with normal group comparison,
▲ ▲p < 0.01, difference is extremely remarkable,
▲p < 0.05, significant difference; With model group comparison,
*p < 0.01, difference is extremely remarkable,
*p < 0.05, significant difference; With positive controls comparison,
★ ★p < 0.01, difference is extremely remarkable,
★p < 0.05, significant difference.
3.2 impacts of embodiment 1 granule on intemperance of taking food rat gastric juice composition
Result table 6, as known from Table 6: intemperance of taking food causes in the gastric juice of Rats with Spleen-deficiency, total acidity output, pepsin activity and pepsin output, are all extremely significantly lower than normal group (P < 0.05).Positive controls and height, middle dosage group can significantly be improved above-mentioned situation, show as and increase total acidity, total acid output stomach function regulating protease output, improve pepsin activity, reach normal group level (P>0.05), and positive controls and high, medium and low dosage group difference is not significantly (P>0.05) all, with model group significant difference (P < 0.01 or P < 0.05).
The impact of table 6 on intemperance of taking food type Rats with Spleen-deficiency gastric juice composition
Note: with normal group comparison,
▲ ▲p < 0.01, difference is extremely remarkable,
▲p < 0.05, significant difference; With model group comparison,
*p < 0.01, difference is extremely remarkable,
*p < 0.05, significant difference; With positive controls comparison,
★ ★p < 0.01, difference is extremely remarkable,
★p < 0.05, significant difference.
3.3 impacts of embodiment 1 granule on intemperance of taking food type Rats with Spleen-deficiency serum gastrin
Result is referring to table 7, as known from Table 7: model group and normal group comparing difference highly significant (P < 0.05), illustrate that Rats with Spleen-deficiency exists the remarkable reduction of level of serum gastrin; Low dose group and normal group comparison, difference is (P < 0.01) extremely significantly, and with model group comparison, difference is remarkable (P>0.05) not; All the other each treatment groups and normal group comparison, difference is remarkable (P>0.05) not, and with model group comparison, difference is remarkable (P < 0.01 or P < 0.05) not.Positive controls and high, middle dosage group difference is not significantly (P>0.05) all, with low dose group significant difference P < 0.05).
The impact of table 7 embodiment 1 granular preparation on intemperance of taking food type Rats with Spleen-deficiency serum gastrin
Note: with normal group comparison,
▲ ▲p < 0.01, difference is extremely remarkable;
▲p < 0.05, significant difference.With model group comparison,
*p < 0.01, difference is extremely remarkable;
*p < 0.05, significant difference.With positive controls comparison,
★ ★p < 0.01, difference is extremely remarkable;
★p < 0.05, significant difference.
3.4 impacts of embodiment 1 granule on intemperance of taking food type Rats with Spleen-deficiency serum motilin
Result is referring to table 8, as known from Table 8: model group and normal group comparison, difference is (P < 0.01) extremely significantly, illustrates that Rats with Spleen-deficiency exists the remarkable rising of plasma motilin.After administration, positive controls is compared difference not remarkable (P>0.05) with high, middle dosage group with normal group, compare significant difference (P < 0.05) with model group; And positive controls is compared difference not remarkable (P>0.05) with high, middle dosage group; Low dose group is compared significant difference (P < 0.05) with normal group.Illustrate that embodiment 1 granule contributes to the adjusting of intemperance of taking food type Rats with Spleen-deficiency serum motilin, wherein, high dose all has good curative effect.
The impact of table 8 the present embodiment 1 preparation on intemperance of taking food type Rats with Spleen-deficiency serum motilin
Note: with normal group comparison,
▲ ▲p < 0.01, difference is extremely remarkable,
▲p < 0.05, significant difference; With model group comparison,
*p < 0.01, difference is extremely remarkable.
*p < 0.05, significant difference; With positive controls comparison,
★ ★p < 0.01, difference is extremely remarkable,
★p < 0.05, significant difference.
Four, conclusion
Known from the above results: the prepared granule of embodiment 1 is high, dosage intemperance of taking food type Rats with Spleen-deficiency is had to good curative effect.
Test example 3
One, experiment purpose
By 1 impact of prepared preparation on the spleen-stomach disease patient of relative analysis Evaluation operation example.
Two, experimental technique
2.1 clinical data
Diagnosis and typing standard are with reference to < < new Chinese medicine guideline of clinical investigations > >.Inclusive criteria for have upper abdomen distending pain, early full, belch, feel sick, the indigestion symptom such as vomiting, pantothenic acid continue more than 5 weeks, endoscopy is not found the organic diseases such as erosion, ulcer, tumor, laboratory, B ultrasonic and x-ray etc. inspections are got rid of liver, gallbladder, pancreopathy change, non-diabetic, connective tissue disease, psychosis and abdominal operation medical history.Totally 120 examples, 30 examples as a control group 1,30 example as a control group 2,30 examples as a control group 3,30 examples as embodiment group.
2.2 Therapeutic Method
Embodiment group is taken the prepared preparation of above-described embodiment 1 3g/ time, three times on the one (morning, noon and afternoon take before the meal half an hour); Matched group 1 is oral not husky Billy 5mg before the meal, every day 3 times, rabeprazole 20mg, every day 1 time; Matched group 2: a kind of Chinese medicinal composition granules, formula and the preparation method of granule is basic identical described in itself and embodiment 1, difference is: in matched group 2 in major ingredient containing Herba Dendrobii and Rhizoma Dioscoreae; Matched group 3: a kind of Chinese medicinal composition granules, adjuvant and the preparation method of granule is basic identical described in itself and embodiment 1, difference is: in matched group 3 in major ingredient only containing Herba Dendrobii and Rhizoma Dioscoreae.
2.3 criterion of therapeutical effect
Symptom score standard: FD common sympton is divided into 4 grades according to the difference of degree and scores.Asymptomatic is 0 minute, after prompting, can recognize that symptom exists for 1 minute, and symptom exists but normal activity is not limited as 2 minutes, has symptom and normal activity to be limited as 3 minutes.General curative effect evaluation criterion: according to the cardinal symptom integral and calculating therapeutic index before and after treatment.Therapeutic index=[integration before (the rear integration of integration-treatment before treatment) ÷ treatment] * 100%.Clinical recovery is that cardinal symptom disappears substantially, and therapeutic index is more than or equal to 90%.Effective for cardinal symptom is clearly better, therapeutic index is 60%～90%.Effectively, for cardinal symptom take a favorable turn, therapeutic index is 30%～60%.Even invalid, for cardinal symptom, without being clearly better, increase the weight of, therapeutic index is less than 30%.
2.4 statistical analysis
All datas are with mean ± standard deviation
represent, adopt t check to process.
Three, experimental result
Result is referring to table 9 and table 10, from table 9 and table 10: the various embodiments described above to upper abdomen distending pain, early full, belch, feel sick, the indigestion symptom such as vomiting, pantothenic acid has good curative effect, and the matched group that is better than evident in efficacy, effective percentage reaches 93.33%.
Before and after table 9 treatment, respectively organize symptom integral comparison
Note: with this group before treatment,
*p < 0.01, difference is extremely remarkable,
*p < 0.05, significant difference.
Table 10 is respectively organized general curative effect comparative result (%)
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a Chinese medicine composition with strengthening the spleen and nourishing the stomach effect, is characterized in that, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts:
Herba Dendrobii 2-40 part, Rhizoma Dioscoreae 1-40 part, Fructus Hippophae 2-40 part, Fructus Crataegi 2-40 part, Fructus Hordei Germinatus (parched) 2-40 part, Endothelium Corneum Gigeriae Galli 2-40 part, Semen Raphani 2-40 part.
2. the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect according to claim 1, is characterized in that, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts:
Herba Dendrobii 2-20 part, Rhizoma Dioscoreae 2-20 part, Fructus Hippophae 3-30 part, Fructus Crataegi 2-30 part, Fructus Hordei Germinatus (parched) 2-30 part, Endothelium Corneum Gigeriae Galli 3-40 part, Semen Raphani 3-30 part.
3. the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect according to claim 2, is characterized in that, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts:
Herba Dendrobii 2-12 part, Rhizoma Dioscoreae 2-10 part, Fructus Hippophae 3-15 part, Fructus Crataegi 2-14 part, Fructus Hordei Germinatus (parched) 2-14 part, Endothelium Corneum Gigeriae Galli 3-20 part, Semen Raphani 3-15 part.
4. the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect according to claim 3, is characterized in that, the effective ingredient of described Chinese medicine composition is mainly prepared from by the raw material of following weight parts:
Herba Dendrobii 3-5 part, Rhizoma Dioscoreae 5-7 part, Fructus Hippophae 5-7 part, Fructus Crataegi 5-7 part, Fructus Hordei Germinatus (parched) 5-7 part, Endothelium Corneum Gigeriae Galli 7-9 part, Semen Raphani 5-7 part.
5. a preparation method for the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect as described in claim 1-4 any one, is characterized in that, comprises the steps:
Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani are cured under 60-80 ℃ of condition, pulverize, add acceptable adjuvant on medicine or on health food, mix and make regular dosage form.
6. a preparation method for the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect as described in claim 1-4 any one, is characterized in that, comprises the steps:
Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani are cured under 60-80 ℃ of condition, pulverize, water and/or ethanol extract, filter, obtain filtrate, after filtrate is concentrated, add acceptable adjuvant on medicine or on health food, mix and make regular dosage form.
7. the preparation method with the Chinese medicine composition of strengthening the spleen and nourishing the stomach effect according to claim 6, is characterized in that, the method for described extraction is water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method.
8. a preparation method for the Chinese medicine composition with strengthening the spleen and nourishing the stomach effect as described in claim 1-4 any one, is characterized in that, comprises the steps:
Herba Dendrobii, Rhizoma Dioscoreae, Fructus Hippophae, Fructus Crataegi, Fructus Hordei Germinatus (parched), Endothelium Corneum Gigeriae Galli and Semen Raphani merge, and extracting in water filters, and obtains filtrate, adds acceptable adjuvant on medicine or on health food, mixes and make regular dosage form.
9. the Chinese medicine composition as described in claim 1-4 any one has the application in the medicine of strengthening the spleen and nourishing the stomach effect in preparation.
10. application according to claim 9, is characterized in that, the dosage form of described medicine is: tablet, capsule, pill, granule, powder, oral liquid, decoction or unguentum.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104351436A (en) * | 2014-11-26 | 2015-02-18 | 湖南中医药大学 | Spleen tonifying and appetizing health tea bag |
| CN105380047A (en) * | 2015-11-24 | 2016-03-09 | 柳超 | Compound nutritional beverage and preparation method thereof |
| CN105410538A (en) * | 2015-11-24 | 2016-03-23 | 柳超 | Lipid-lowering cereal beverage and preparation method of the lipid-lowering cereal beverage |
| CN106075338A (en) * | 2016-07-06 | 2016-11-09 | 湖南净初社区健康科技有限公司 | Health-care Chinese medicinal composition and its preparation method and application |
| CN107812082A (en) * | 2017-11-07 | 2018-03-20 | 黄建文 | A kind of Chinese medicinal capsule with functions of strengthening stomach and promoting digestion and preparation method thereof |
| CN112043806A (en) * | 2020-10-26 | 2020-12-08 | 北京沃德中医药研究院 | Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof |
| CN112741187A (en) * | 2021-01-14 | 2021-05-04 | 山西振东五和健康科技股份有限公司 | Chocolate composition with digestion promoting function and preparation method thereof |
| CN114377089A (en) * | 2021-11-30 | 2022-04-22 | 北京太论医道医学研究院(有限合伙) | Composition with spleen and stomach strengthening function and application thereof |
-
2014
- 2014-07-15 CN CN201410336077.6A patent/CN104127758A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 李杰: "《常用中药临床妙用辑解》", 31 August 2008 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104351436A (en) * | 2014-11-26 | 2015-02-18 | 湖南中医药大学 | Spleen tonifying and appetizing health tea bag |
| CN105380047A (en) * | 2015-11-24 | 2016-03-09 | 柳超 | Compound nutritional beverage and preparation method thereof |
| CN105410538A (en) * | 2015-11-24 | 2016-03-23 | 柳超 | Lipid-lowering cereal beverage and preparation method of the lipid-lowering cereal beverage |
| CN106075338A (en) * | 2016-07-06 | 2016-11-09 | 湖南净初社区健康科技有限公司 | Health-care Chinese medicinal composition and its preparation method and application |
| CN107812082A (en) * | 2017-11-07 | 2018-03-20 | 黄建文 | A kind of Chinese medicinal capsule with functions of strengthening stomach and promoting digestion and preparation method thereof |
| CN112043806A (en) * | 2020-10-26 | 2020-12-08 | 北京沃德中医药研究院 | Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof |
| CN112741187A (en) * | 2021-01-14 | 2021-05-04 | 山西振东五和健康科技股份有限公司 | Chocolate composition with digestion promoting function and preparation method thereof |
| CN114377089A (en) * | 2021-11-30 | 2022-04-22 | 北京太论医道医学研究院(有限合伙) | Composition with spleen and stomach strengthening function and application thereof |
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