CN105943615A - Application of whole hemp extract in preparation of pancreatic cancer treating drug - Google Patents
Application of whole hemp extract in preparation of pancreatic cancer treating drug Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses application of a whole hemp extract in preparation of a pancreatic cancer treating drug. The whole hemp extract is prepared by evenly mixing, by weight, 0.3-99.7 parts of an industrial hemp and fructus cannabis extract and 0.3-99.7 parts of an industrial hemp and cannabis sativa L extract. It is found through clinical observation that the whole hemp extract can reduce masses, effectively control cancer cell metastasis and spread and inhibit cancer cell growth, can strengthen the body immunity, relieve the suffering of patients, stabilize the state of illness, prolong lifetime and increase the percentage of clinically cured patients while treating and resisting cancers, can greatly reduce the recurrence and metastasis of residual cancer cells and is higher than cannabidiol in anti-tumor effect. The invention further provides a pancreatic cancer treating pharmaceutical preparation of the whole hemp extract and a corresponding drug dosage form. A variety of different dosage forms of drugs for clinical use can be prepared by adopting a conventional preparation method, and the whole hemp extract is convenient to use.
Description
Technical field
The invention belongs to industrial hemp and utilize technical field, concretely relating to one with industrial hemp is
The pharmaceutical composition that primary raw material prepares application in the medicine of preparation treatment cancer of pancreas.
Background technology
The plantation of Fructus Cannabis is with a long history, ancient times Fructus Cannabis be mainly used in fabrication and processing rope, fishing net, clothing and
Paper making raw material, and oils and fats, food etc..Development and progress along with society, it has been found that contain in Fructus Cannabis
Having a kind of toxic component (tetrahydrocannabinol) that people can be made to cause unreal addiction, American-European many countries are once considerably long
Forbid cultivating in period Fructus Cannabis.Owing to the economic use value of Fructus Cannabis is high, to the eighties in 20th century, some Europe
Low toxicity Hemp Varieties the plantation that puts it over have been cultivated in the research of continent country.Nineteen ninety, the European Community took the lead in promptly
Revision agricultural policy, has abolished the ban of Fructus Cannabis of forbidding cultivating, has started to recover the production of Fructus Cannabis and research.Subsequently
The states such as the U.S., Canada, Australia relieve Fructus Cannabis plantation ban, the whole world Fructus Cannabis cultivated area and
Fiber production has had and has increased rapidly, and the exploitation of industrial hemp are started by American-European countries again, international city
The demand of ecological Fructus Cannabis is also being increased rapidly by field.According to the economic attribution of Fructus Cannabis, for making full use of it it is
The mankind service, and within 1988, the United Nations's clear stipulaties does not possess extraction toxic component (tetrahydrocannabinol THC)
It is worth or sucks directly as drugs, specializing in the raw material Fructus Cannabis of industrial use, industrial hemp (its growth
Tetrahydrocannabinol content in phase Fructus Cannabis floral leaf is less than 0.3%), legal can carry out implantation in large scale and work
Industryization develops.
Industrial hemp be show unique characteristics, living resources that comparative advantages are prominent.Industrial hemp and conventional toxic
Fructus Cannabis has essential distinction, and industrial hemp is the raw material of industry product of a class Non-toxic, has high warp
Ji value.Successively 25 industrial hemp kinds are selected altogether to countries in the world at the end of 2003, and
And seven states such as the method for European Union, moral, English the most all become industrial hemp and mainly plant manufacturing country, with industrial hemp
Fiber and fiber crops seed and flower thereof, leaf, root, stem are that raw material carries out series of products research and development and industrialization comprehensive exploitation,
Industrial hemp primary process major product jute skin fiber, stalk core fibre, hemp seed oil fat and seed cake protein,
On the basis of medicinal standard extract realizes industrialization production, carry out deep processing and utilization further, derive from
Product out has reached more than 25,000 kinds, contain the clothing of the mankind, food, shelter, row, with each greatly
Series products.The research of industrial hemp industry, develop and production is concentrated mainly on Europe, Canada, the U.S.
Etc. technology developed country.The development of industrial hemp industry, is first nontoxic from selection-breeding or the low industry poisoned
Fructus Cannabis new varieties start, and achieve the plantation of scale and combining of hi-tech industrialization based on this
Close and develop, define one " emerging pollution-free industry group " and the quick growth point of infant industry economy.
Fructus Cannabis is Fructus Cannabis dry mature fruit, is generally used as medicine by Fructus Cannabis ancient times, and dietetic therapy is the most on the books.
Fructus Cannabis is included in " being medicine and food " " medicine-food two-purpose " list by health ministry.
The property of medicine of Fructus Cannabis and pharmacology be: sweet, flat.Return spleen, stomach, large intestine channel.Function cures mainly: moisturize, sliding
Intestinal, treating stranguria, invigorate blood circulation.Control dryness of the intestine constipation, quench one's thirst, pyretic stranguria, migratory arthralgia, dysentery.Menoxenia, scabies,
Tinea leprosy.Those benefits in detail is had to record in medical book, such as " herbal classic ": " invigorating the spleen and replenishing QI.”；Tang Materia Medica: " main
Five kinds of over strain.”；" Handbook of Prescriptions for Emergencies ": " control extreme thirst, day eclipse number bucket, hot urination person: pockmarks one liter, three liters of water,
Boiling three, four boilings, extracting juice drinks it.”；" Japan hanako materia medica ": " qi-restoratives labor, long muscle, stimulating milk secretion, only disappear
Yearningly, expedite the emergence of.Control perverse and unreasonable manner to produce.”；Supplement to the Herbal: " therapeutic method to keep the adverse QI flowing downwards, diuresis, go migratory arthralgia skin stupid, fries order
Perfume (or spice) is smashed to pieces, urine leaching juice clothes；Married woman's footling presentation gulps down two or seven pieces.”；" Treatise on Dietetic Therapy ": " extracting juice is cooked congee,
Go the five internal organs wind, lung moistening.Control that joint is obstructed, deal with, promoting blood circulation.”.
The equal hyoscine of floral leaf of Fructus Cannabis.The property of medicine of Folium Cannabis and pharmacology be: pungent；Poisonous.Return lung；Bladder；
Large intestine channel.Function cures mainly: pain relieving, and Dingchuan drives ascarid.Cure mainly asthma, fall and flutter pain, ascariasis.Fiber crops
The property of medicine and the pharmacology of flower be: bitter；Pungent；Warm in nature；Poisonous.Function cures mainly: dispel the wind；Invigorate blood circulation；Hair growth promoting.
Main air disease numb limbs and tense tendons；Pruritus all over；Women's amenorrhea.
Cancer of pancreas is more rare in malignant tumor of digestive tract, is more common in 40～60 years old, and man is more than female, pancreas
Adenocarcinoma mostly occurs at Diseases In Pancreatic Head, and only minority occurs in body of pancreas and tail of pancreas portion.Cancer of pancreas occurs due to cancerous protuberance
The morning and evening of position and the course of disease is different, and clinical symptoms is different.Stomachache is the symptom occurred the earliest, is more common in pancreas
Body and tail of pancreas portion, big multidirectional lower back radiates.The state of an illness can have jaundice in evolution, may occur in which late period
Abdominal mass, heating, supraclavicular lymph nodes is modal metastasis site.Modern medicine thinks that primary disease can
Can be relevant with carcinogen, coffee, smoking and chronic pancreatic diseases in environment.Cancer of pancreas be one more
Dangerous malignant tumor, although in every 20,000 people of China, about 1 people suffers from cancer of pancreas, but this disease develops
The fast case fatality rate of speed is high.NIH reports, 1 year survival rate of cancer of pancreas is 8%, 5
Year survival rate 3%.5 years survival rates only about 5% of China's Statistical data.Sickness rate shows year by year in recent years
Writing and rise, U.S.'s cancer of pancreas sickness rate increased 3 times between 10 years, neopathy 43140 example in 2010,
Dead 36800 examples, occupy Incidence the tenth, and mortality rate is but in the 4th.China's cancer of pancreas
Morbidity and death toll ascendant trend highly significant especially, nearly 20 annual morbidities increase about 6 times.According to
38 registry, whole nation tumor registration data in 2007, cancer of pancreas morbidity occupies malignant tumor the 7th, sick
Dead rate occupies malignant tumor the 6th.Therefore, study new effective treatment of pancreatic cancer medicine and be still current pancreas
The Main way of adenocarcinoma treatment.
Cannabidiol (CBD) is that a kind of nontoxic of extraction from Fructus Cannabis floral leaf can be used for medicine, cosmetic
Product, the aldehydes matter of a kind of high added value of health food.At present, Israel, the U.S., Britain etc. are sent out
Reach country done raw material with it and developed multiple special effect medicine and cosmetics.CBD is the non-one-tenth in Fructus Cannabis
Addiction composition, can hinder THC to affect nerve system of human body, and have spasmolytic, antirheumatic joint
The pharmacologically actives such as inflammation, anxiety, also have the report in terms for the treatment of cancer of pancreas, but are used alone Fructus Cannabis two
The therapeutic effect of phenol (CBD) is unsatisfactory.Therefore new activity is developed high, the treatment that toxic and side effects is little
Medicine seems the most necessary.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition prepared with industrial hemp for primary raw material
The application in pharmacy of the general anesthesia element.
It practice, the present invention relates to the application in the medicine of preparation treatment cancer of pancreas of the general anesthesia element；Described
General anesthesia element is by 0.3 part～the industrial hemp Fructus Cannabis extract of 99.7 weight portions and 99.7 parts～0.3 weight
The industrial hemp Urtica cannabina L. element mixing of amount part is made.
The raw material composition of described general anesthesia element is preferably industrial hemp Fructus Cannabis extract 40 parts and industry is big
Fiber crops Urtica cannabina L. element 60 parts.
Wherein, described industrial hemp Fructus Cannabis extract is prepared by the following method and forms:
(1) ripe industrial hemp Fructus Cannabis is taken, drying, remove impurity, standby after pulverizing；
(2) under the conditions of 20～85 DEG C, extract pulverizing Fructus Cannabis material with ethanol, concentration of alcohol
Being 95%～100% (V/V), solid-liquid ratio is 1:5～1:20；
(3) leach lixiviating solution, after concentrating under reduced pressure, be industrial hemp Fructus Cannabis extract.
When industrial hemp Fructus Cannabis being extracted with ethanol, following various ways can be used to carry out: as
Extract under room temperature, every batch materials extraction 2 times, each 7～10 days；Under the conditions of 60～85 DEG C, heating
Extract 2 times, each 1～3 hour；Ultrasonic assistant extracts, ultrasonic frequency 30～60kHz, merit
Rate 100～1000W, extraction time 30～60min, extraction temperature 25～50 DEG C；Also microwave can be used
Other prior art such as assisted extraction.
Described industrial hemp Urtica cannabina L. element is prepared by the following method and forms:
(1) flower of industrial hemp, leaf, fiber crops bran or the mixture of three, drying, remove impurity, powder are taken
It is broken to 10～60 mesh；
(2) supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is put into supercritical
In carbon dioxide extraction apparatus, control extraction temperature 40～50 DEG C, extraction time 30～90min, extraction
Pressure 25～35Mpa, carbon dioxide flow 40kg/h, extract is collected in separating still outlet；
(3) the extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, eluting
Number of times is 1～3 time；
(4) eluent is collected, concentrating under reduced pressure, vacuum drying, i.e. obtain industrial hemp Urtica cannabina L. element after pulverizing.
The flower of described industrial hemp, leaf, the optimum ratio of fiber crops bran three's mixture are 1:3:2.
Common Folium Cannabis, Flos Cannabis be respectively provided with toxicity (containing tetrahydrocannabinol THC marijuana hemp to the most unreal
Material).For getting rid of the toxicity of crude drug, present invention preferably employs the industrial hemp kind of Yunnan growth
Flower, leaf, fiber crops bran and the Fructus Cannabis of " cloud fiber crops No. 1 " are as raw material.By China's relevant legal documents rule
Fixed, " cloud fiber crops No. 1 " can only be planted within the border in Yunnan, and its flower, leaf, numb bran can only be in border, Yunnan
Interior processing.
The pharmaceutical composition general anesthesia element of the present invention can make different pharmaceutical preparation, further including being administered orally
Agent and injection, wherein oral agents includes capsule, oral liquid, tablet, drop pill, granule etc., injection
Including injection dosage form and freeze-dried powder injection type etc..The available auxiliary type when preparing oral formulations
Agent can be the conventional filler such as starch, dextrin or cyclodextrin, sucrose, stearate.Lyophilized injectable powder
Can be prepared by methods such as aseptic spray drying, low-temperature vacuum drying, lyophilizations.After each preparation
Phase preparation technology and equipment all belong to the routine techniques of pharmaceutical field, and this is not construed as limiting by the present invention, therefore at this
Not describe in detail.
The pharmaceutical composition general anesthesia element of the present invention has the effect of clear and definite treatment cancer of pancreas.Experiment is sent out
Existing, general anesthesia element antitumor action is significantly higher than cannabidiol.Clinical observation finds, the general anesthesia element of the present invention
Can reduce lump, effectively control cancer cell metastasis diffusion, anticancer grows, for cancer anticancer same
Time, can enhancing human body immunity power, alleviate patient suffering, stablize the state of an illness, extend life cycle and increase and face
The ratio of patient cured by bed, and can be substantially reduced remaining cancerous cell relapse and metastasis, and action effect is better than Fructus Cannabis
Diphenol.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but embodiment is not to this
The restriction of bright technical scheme.
Embodiment 1
Use flower, leaf, fiber crops bran and the Urtica cannabina L. of the industrial hemp kind " cloud fiber crops No. 1 " of Yunnan growth
Core is as raw material.Take maturation industrial hemp Fructus Cannabis, drying, remove impurity, standby after pulverizing；Use second
Alcohol to pulverize Fructus Cannabis material extract (under the conditions of 60～85 DEG C, heating extraction 2 times, each 1～
3 hours), concentration of alcohol is 95%～100% (V/V), and solid-liquid ratio is 1:5～1:20；Leach lixiviating solution,
Industrial hemp Fructus Cannabis extract it is after concentrating under reduced pressure.
Take the flower of industrial hemp, leaf, fiber crops bran 1:3:2 mass ratio mixture, drying, remove impurity,
It is crushed to 10～60 mesh；Supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is thrown
Enter in supercritical carbon dioxide extraction apparatus, control extraction temperature 40～50 DEG C, extraction time 30～
90min, extracting pressure 25～35Mpa, carbon dioxide flow 40kg/h, extraction is collected in separating still outlet
Thing；The extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, washing steps
It it is 1～3 time；Collect eluent, concentrating under reduced pressure, vacuum drying, after pulverizing, obtain industrial hemp Urtica cannabina L.
Element.
Take industrial hemp Fructus Cannabis extract 40 parts, industrial hemp Urtica cannabina L. element 60 parts, mixing, obtain required
General anesthesia element B.
Embodiment 2
Repeat embodiment 1, have following difference: when industrial hemp Fructus Cannabis being extracted with ethanol,
Extract under room temperature, every batch materials extraction 2 times, each 7～10 days.Take the flower of industrial hemp, leaf, fiber crops
The mixture of bran 1:1:1 mass ratio is as the extraction raw material of industrial hemp Urtica cannabina L. element.
Take industrial hemp Fructus Cannabis extract 0.3 part, industrial hemp Urtica cannabina L. element 99.7 parts, mixing, obtain
Required general anesthesia element A.
Embodiment 3
Repeat embodiment 1, have following difference: when industrial hemp Fructus Cannabis being extracted with ethanol,
Employing ultrasonic assistant extracts, and ultrasonic frequency 30～60kHz, power 100～1000W, during extraction
Between 30～60min, extraction temperature 25～50 DEG C.Take the flower of industrial hemp, leaf, fiber crops bran 3:2:1 matter
The mixture of amount ratio is as the extraction raw material of industrial hemp Urtica cannabina L. element.
Take industrial hemp Fructus Cannabis extract 99.7 parts, industrial hemp Urtica cannabina L. element 0.3 part, mixing, obtain
Required general anesthesia element C.
Embodiment 4
Example 1 gained medicine 100 grams (crosses 80 mesh sieves), adds 60 grams of microcrystalline Cellulose, crosses 80
Mesh sieve three times, mix homogeneously, spray into 95% ethanol solution, soft material processed, cross 40 mesh sieves and pelletize, 60 DEG C
It is dried half an hour, is sub-packed in 3# capsule, aluminium plastic composite packaging, prepare general anesthesia cellulose capsule agent.
Embodiment 5
Example 2 gained medicine, admixture doses 5～the dried starch of 20% and 1～the stearic acid of 5%
Magnesium etc., blended, pelletize, be dried, tabletting, prepare general anesthesia element tablet.
Embodiment 6
The adjuvants such as Example 3 gained medicine, adds sucrose water and the preservative of convention amount, stabilizer.
Filtration, sterilizing, be distributed in 10mL bottle, make general anesthesia element oral liquid.
Embodiment 7
Example 1 gained medicine, adds water for injection and dissolves, add 2.0 ‰ activated carbons, stir,
Filter, continue, with 0.45 μm, 0.22 μm microporous filter membrane classified filtering, to supplement water for injection, subpackage
In cillin bottle, lyophilization, recharge high-purity nitrogen, jump a queue, gland, packaging, prepare general anesthesia element
Injection.
The therapeutical effect evaluation to mouse pancreas cancer of the Application Example 1 general anesthesia element
Human pancreas cancer cell strain Patu 8988 is put in the RPMI-1640 complete medium containing 10% and train
Support.Take the logarithm the human pancreas cancer cell strain of trophophase, by every 5 × 106Individual tumor cell inoculation is in naked
At mouse armpit, set up tumor model.
Take modeling successful nude mouse 60, measure gross tumor volume, be randomly divided into 3 groups, often group 20,
I.e. normal saline group, general anesthesia element A, B, C group and cannabidiol group.Normal saline group subcutaneous injection gives
Normal saline；General anesthesia element group cannabidiol group and cannabidiol group equal subcutaneous injection 2mg/kg.Every treated animal,
It is given daily 1 time, successive administration 12 days, measures gross tumor volume after administration, calculate tumour inhibiting rate, and unite
Count during each treated animal is administered and be administered the mortality rate terminating in latter 10 days.Result see table.
Table 1: respectively organize tumour inhibiting rate (%) and each treated animal mortality rate (%) after administration
Experimental result shows: general anesthesia element antitumor action is significantly higher than cannabidiol.Of the present invention entirely
Fiber crops element has significantly treatment cancer of pancreas effect.
The clinical observation of Application Example 2 general anesthesia extract for treating cancer of pancreas
1, case packet and therapeutic scheme: cancer of pancreas case 300 example, the maleest 176 examples, female 124
Example, patient, from 31 years old～76 years old, is randomly divided into general anesthesia element group, chemotherapy group and cannabidiol group by the age；
Cannabidiol group 100 people, male 61 people, female 39 people.The capsule that oral cannabidiol makes is (big
Fiber crops diphenol 100 grams, makes 1000), three times a day, each 6, be 1 course for the treatment of with one month,
It serve on 1-3 the course for the treatment of.
Chemotherapy group 100 people, male 59 people, female 41 people, chemotherapeutics selection cisplatin (CDDP) 30mg/M2d1-3,
Gemzar 1000mg/M2d1,8,15, fluorouracil (5-Fu) 500mg/M2d1-5, select wherein during chemotherapy
2 kinds or 3 kinds of drug combinations, intravenously administrable, 28 days is a cycle.
General anesthesia element group 100 people, male 56 people, female 44 people, the glue that oral B general anesthesia element of the present invention makes
Wafer (B general anesthesia element 100 grams, make 1000), three times a day, each 6, with one month
It is 1 course for the treatment of, serve on 1-3 the course for the treatment of.
All patient radiation all confirm through pathology before treating, and all have x-ray to take the photograph sheet, CT scan or nuclear-magnetism
Resonance checks for clinical TNM by stages, checks and confirm without chemicotherapy before chemotherapy before all doing chemotherapy by clinical criteria
Contraindication, all patients are all without transfer cancer of pancreas (MO).
International cancer of pancreas TNM by stages with clinical stages:
International cancer of pancreas TNM (UICC, 1987) by stages, T refers to primary tumo(u)r situation, and N refers to lymph metastasis
Situation, M refers to metastasis situation.
(1) primary tumo(u)r (T) is by stages:
Tx: can not judge；T0: without primary tumo(u)r evidence；T1: primary swollen without departing from pancreas；T1a:
Tumor≤2cm；T1b: tumor ＞ 2cm；T2: group around tumor invading duodenum, biliary tract or pancreas
Knit；T3: tumor invading stomach, spleen, colon, big blood vessel.
(2) zonule lymph node (N) is by stages:
Nx: can not judge；NO: regional lymph nodes is without transfer；Nl: have regional lymph node metastasis；
(3) metastasis (M) is by stages:
Mx: can not judge；MO: without metastasis；Ml: have metastasis.
Clinical stages
The I phase: T1 NO MO；T1 NX MO；TX NO MO；TX NX MO.
The II phase: T2 NO MO；T2 NX MO；T3 NO MO；T3 NX MO.
The III phase: any T, N1, MO:.
The IV phase: any T, any N, Ml.
2, evaluation criteria: evaluate curative effect according to WHO treatment malignant tumor evaluation criteria, point complete incidence graph:
All visible pathological changes were wholly absent at least 4 weeks；Part alleviate: tumor size estimate reduce >=50% to
Few 4 weeks；Unchanged: without significant change at least 4 week, stable including pathological changes, tumor size is estimated to expand
Less than 25%, reduce less than 50%；Pathological changes extends: new focus occurs or original pathological changes is estimated to expand ＞
25%；4 ranking pancreas portion's primary tumors and the change of Metastatic Lymph Nodes gross tumor volume.
3, result of the test:
According to above-mentioned WHO evaluation criteria, drug treatment is after 4 months respectively, carries out short term effect effect system
Meter, the results are shown in Table 2.
Table 2: each group short term effect tracking table record
By table 2, the general anesthesia element of the present invention can be obviously reduced lump, effectively controls cancerous cell and expands
Dissipate, increase the ratio of clinical cure patient, and by clinical observation, every day patient's patient's condition inquiry sum up with
And regularly x-ray, CT or ultrasound diagnosis etc., determine the general anesthesia element preparation of the present invention can quickly alleviate or
Eliminate that epigastrium distension is uncomfortable or distending pain, jaundice, tired, loss of appetite, become thin, suffer from diarrhoea or constipation etc.
Symptom, alleviates patient suffering, stablizes the state of an illness；Effect is better than cannabidiol and chemotherapy.
All patients are carried out long-term follow record, and unites respectively when 1 year, 2 years, 3 years and 5 years
Meter survival number and survival rate, concrete data are shown in Table 3.
Table 3: each group long-term survival rate follows the tracks of survival number and survival rate
| Group | 1 year | 2 years | 3 years | 5 years |
| Cannabidiol group | 48 (48%) | 36 (36%) | 27 (27%) | 19 (19%) |
| Chemotherapy group | 23 (23%) | 10 (10%) | 2 (2%) | 0 (0%) |
| General anesthesia element group | 65 (65%) | 54 (54%) | 40 (40%) | 34 (34%) |
By table 3, the general anesthesia element of the present invention can significantly improve the life span of Pancreas cancer patients,
Improve the ratio of clinical cure patient；General anesthesia element effect is better than cannabidiol and chemotherapy.
Claims (6)
1. general anesthesia element application in the medicine of preparation treatment cancer of pancreas；Described general anesthesia element by 0.3 part～
The industrial hemp Fructus Cannabis extract of 99.7 weight portions and 99.7 parts～the industrial hemp fire of 0.3 weight portion
Fiber crops element mixing is made.
Application the most according to claim 1, it is characterised in that: the raw material group of described general anesthesia element
Become to be preferably industrial hemp Fructus Cannabis extract 40 parts and industrial hemp Urtica cannabina L. element 60 parts.
Application the most according to claim 1, it is characterised in that: described industrial hemp Fructus Cannabis
Extract is prepared by the following method and forms:
(1) ripe industrial hemp Fructus Cannabis is taken, drying, remove impurity, standby after pulverizing；
(2) under the conditions of 20～85 DEG C, extract pulverizing Fructus Cannabis material with ethanol, concentration of alcohol
Being 95%～100% (V/V), solid-liquid ratio is 1:5～1:20；
(3) leach lixiviating solution, after concentrating under reduced pressure, be industrial hemp Fructus Cannabis extract.
Application the most according to claim 1, it is characterised in that: described industrial hemp Urtica cannabina L. element
It is prepared by the following method and forms:
(1) flower of industrial hemp, leaf, fiber crops bran or the mixture of three, drying, remove impurity, powder are taken
It is broken to 10～60 mesh；
(2) supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is put into supercritical
In carbon dioxide extraction apparatus, control extraction temperature 40～50 DEG C, extraction time 30～90min, extraction
Pressure 25～35Mpa, carbon dioxide flow 40kg/h, extract is collected in separating still outlet；
(3) the extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, eluting
Number of times is 1～3 time；
(4) eluent is collected, concentrating under reduced pressure, vacuum drying, i.e. obtain industrial hemp Urtica cannabina L. element after pulverizing.
Application the most according to claim 4, it is characterised in that: the flower of described industrial hemp,
Leaf, the optimum ratio of fiber crops bran three's mixture are 1:3:2.
Application the most according to claim 1, it is characterised in that: the kind of described industrial hemp
It is preferably " cloud fiber crops No. 1 ".
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| CN201610414968.8A CN105943615A (en) | 2016-06-14 | 2016-06-14 | Application of whole hemp extract in preparation of pancreatic cancer treating drug |
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| CN201610414968.8A CN105943615A (en) | 2016-06-14 | 2016-06-14 | Application of whole hemp extract in preparation of pancreatic cancer treating drug |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| US11406913B2 (en) | 2013-10-04 | 2022-08-09 | Natural Extraction Systems, LLC | Method and apparatus for extracting botanical oils |
| US11643402B2 (en) | 2018-08-10 | 2023-05-09 | Natural Extraction Systems, LLC | Gas phase methods to decarboxylate cannabinoids |
| US11702397B2 (en) | 2018-08-10 | 2023-07-18 | Natural Extraction Systems, LLC | Methods to purify cannabinoids |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11406913B2 (en) | 2013-10-04 | 2022-08-09 | Natural Extraction Systems, LLC | Method and apparatus for extracting botanical oils |
| WO2018102711A1 (en) * | 2016-12-01 | 2018-06-07 | Natural Extraction Systems, LLC | Rapid botanical oil distillation device utilizing microwave agent |
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| WO2019161231A1 (en) * | 2018-02-16 | 2019-08-22 | Botanical Process Solutions LLC | Use of non-crystalline terpene alcohols for the inhibition of crystallization of cannabinoids |
| US11643402B2 (en) | 2018-08-10 | 2023-05-09 | Natural Extraction Systems, LLC | Gas phase methods to decarboxylate cannabinoids |
| US11702397B2 (en) | 2018-08-10 | 2023-07-18 | Natural Extraction Systems, LLC | Methods to purify cannabinoids |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
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