CN106074709A - A kind of medicine treating cancer of pancreas - Google Patents
A kind of medicine treating cancer of pancreas Download PDFInfo
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- CN106074709A CN106074709A CN201610415401.2A CN201610415401A CN106074709A CN 106074709 A CN106074709 A CN 106074709A CN 201610415401 A CN201610415401 A CN 201610415401A CN 106074709 A CN106074709 A CN 106074709A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of medicine treating cancer of pancreas.Described general anesthesia element is made up of the industrial hemp Urtica cannabina L. element mixing of 0.3 part～the industrial hemp Fructus Cannabis extract of 99.7 weight portions and 99.7 parts～0.3 weight portion.Clinical observation finds, this medicine can reduce lump, effectively control cancer cell metastasis diffusion, anticancer grows, for cancer anticancer while, can enhancing human body immunity power, alleviate patient suffering, stablize the state of an illness, extend life cycle and increase clinical cure patient ratio, and remaining cancerous cell relapse and metastasis can be substantially reduced, action effect is better than cannabidiol.
Description
Technical field
The invention belongs to pancreatic cancer medicine field, concretely relate to a kind of with industrial hemp as primary raw material
The pharmaceutical composition of the treatment cancer of pancreas of preparation.
Background technology
The plantation of Fructus Cannabis is with a long history, and ancient times, Fructus Cannabis was mainly used in fabrication and processing rope, fishing net, clothing and paper making raw material,
And oils and fats, food etc..Development and progress along with society, it has been found that containing a kind of toxic component (tetrahydrochysene Fructus Cannabis in Fructus Cannabis
Phenol) people can be made to cause unreal addiction, American-European many countries once forbade cultivating Fructus Cannabis within considerably long period.Economic use value due to Fructus Cannabis
Height, to the eighties in 20th century, low toxicity Hemp Varieties the plantation that puts it over have been cultivated in the research of some European countries.Nineteen ninety Europe
Coenosarc takes the lead in Emergency fixes agricultural policy, has abolished the ban of Fructus Cannabis of forbidding cultivating, has started to recover the production of Fructus Cannabis and research.Beautiful subsequently
The states such as state, Canada, Australia relieve the ban of Fructus Cannabis plantation, and whole world Fructus Cannabis cultivated area and fiber production have had rapidly
Increasing, the exploitation of industrial hemp are started by American-European countries again, and the demand of ecological Fructus Cannabis is also being increased rapidly by international market
Long.According to the economic attribution of Fructus Cannabis, servicing for the mankind for making full use of it, within 1988, the United Nations's clear stipulaties does not possess extraction poison
Property composition (tetrahydrocannabinol THC) be worth or suck directly as drugs, specialize in the raw material Fructus Cannabis of industrial use, industrial hemp
(the tetrahydrocannabinol content in its trophophase Fructus Cannabis floral leaf is less than 0.3%), legal can carry out implantation in large scale and industrialization
Develop.
Industrial hemp be show unique characteristics, living resources that comparative advantages are prominent.Industrial hemp has with conventional toxic Fructus Cannabis
Essential distinction, industrial hemp is the raw material of industry product of a class Non-toxic, has high economic use value.At the end of 2003
Countries in the world successively select altogether 25 industrial hemp kinds, and seven states such as the method for European Union, moral, English the most all become industry greatly
Fiber crops mainly plant manufacturing country, with industrial hemp fibers and fiber crops seed and flower, leaf, root, stem for raw material carry out series of products research and development with
Industrialization comprehensive exploitation, processes major product jute skin fiber, stalk core fibre, hemp seed oil fat and seed dregs of rice egg in industrial hemp primary
In vain, medicinal standard extract realize industrialization produce on the basis of, carry out deep processing and utilization, the product derived from further
Reached more than 25,000 kinds, contain the clothing of the mankind, food, shelter, row, with each big series products.The research of industrial hemp industry,
Exploitation and production are concentrated mainly on the technology developed countries such as Europe, Canada, the U.S..The development of industrial hemp industry, be first
Or the low industrial hemp new varieties that poison nontoxic from selection-breeding start, and achieve the plantation of scale and high skill based on this
The comprehensive development and utilization of art industrialization, defines one " emerging pollution-free industry group " and the quick growth point of infant industry economy.
Fructus Cannabis is Fructus Cannabis dry mature fruit, is generally used as medicine by Fructus Cannabis ancient times, and dietetic therapy is the most on the books.Health ministry
Fructus Cannabis is included in " being medicine and food " " medicine-food two-purpose " list.The property of medicine of Fructus Cannabis and pharmacology be: sweet,
Flat.Return spleen, stomach, large intestine channel.Function cures mainly: moisturize, and laxation is treating stranguria, invigorates blood circulation.Control dryness of the intestine constipation, quench one's thirst, pyretic stranguria, migratory arthralgia, dysentery
Disease.Menoxenia, scabies, tinea leprosy.Those benefits in detail is had to record in medical book, such as " herbal classic ": " invigorating the spleen and replenishing QI.”；Tang Materia Medica:
" main five kinds of over strain.”；" Handbook of Prescriptions for Emergencies ": " control extreme thirst, day eclipse number bucket, hot urination person: pockmarks one liter, three liters of water, boil three, four boilings, extracting juice
Drink it.”；" Japan hanako materia medica ": " qi-restoratives labor, long muscle, stimulating milk secretion, only quench one's thirst, expedite the emergence of.Control perverse and unreasonable manner to produce.”；Supplement to the Herbal: under "
Gas, diuresis, go migratory arthralgia skin stupid, fry and make perfume (or spice) smash to pieces, urine leaching juice clothes；Married woman's footling presentation gulps down two or seven pieces.”；" Treatise on Dietetic Therapy ":
" extracting juice is cooked congee, and goes the five internal organs wind, lung moistening.Control that joint is obstructed, deal with, promoting blood circulation.”.
The equal hyoscine of floral leaf of Fructus Cannabis.The property of medicine of Folium Cannabis and pharmacology be: pungent；Poisonous.Return lung；Bladder；Large intestine channel.Function master
Control: pain relieving, Dingchuan, drive ascarid.Cure mainly asthma, fall and flutter pain, ascariasis.The property of medicine of Flos Cannabis and pharmacology be: bitter；Pungent；Warm in nature；Have
Poison.Function cures mainly: dispel the wind；Invigorate blood circulation；Hair growth promoting.Main air disease numb limbs and tense tendons；Pruritus all over；Women's amenorrhea.
Cancer of pancreas is more rare in malignant tumor of digestive tract, is more common in 40～60 years old, and man is more than female, and cancer of pancreas mostly occurs
Diseases In Pancreatic Head, only minority occur in body of pancreas and tail of pancreas portion.Position and the morning and evening of the course of disease that cancer of pancreas occurs due to cancerous protuberance are different, clinical
Symptom is different.Stomachache is the symptom occurred the earliest, is more common in body of pancreas and tail of pancreas portion, and big multidirectional lower back radiates.The state of an illness is in development
During can have jaundice, may occur in which abdominal mass late period, heating, supraclavicular lymph nodes is modal metastasis site.Modern doctor
Think that primary disease may be relevant with carcinogen, coffee, smoking and chronic pancreatic diseases in environment.Cancer of pancreas is that one is the most fierce
The malignant tumor of danger, although in every 20,000 people of China, about 1 people suffers from cancer of pancreas, but this sick fast-growth case fatality rate is high.Beautiful
NIH of state reports, 1 year survival rate of cancer of pancreas is 8%, 5 years survival rates 3%.5 years survival rates of China's Statistical data
Only about 5%.Sickness rate significantly rises in recent years, and U.S.'s cancer of pancreas sickness rate increased 3 times between 10 years, within 2010, newly sends out
Sick 43140 examples, dead 36800 examples, occupy Incidence the tenth, mortality rate is but in the 4th.China's cancer of pancreas morbidity
With death toll ascendant trend highly significant especially, nearly 20 annual morbidities increase about 6 times.According to 38 registry, the whole nation 2007
Tumor registration data, cancer of pancreas morbidity occupies malignant tumor the 7th, and case fatality rate occupies malignant tumor the 6th.Therefore, new having is studied
The treatment of pancreatic cancer medicine of effect is still the Main way of current treatment of pancreatic cancer.
Cannabidiol (CBD) is that a kind of nontoxic of extraction from Fructus Cannabis floral leaf can be used for medicine, cosmetics, health food
The aldehydes matter of a kind of high added value.At present, the developed country such as Israel, the U.S., Britain has done raw material with it and has developed
Multiple special effect medicine and cosmetics.CBD is the non-additive composition in Fructus Cannabis, and THC can be hindered to affect nerve system of human body, and
There is the pharmacologically actives such as spasmolytic, resisting rheumatoid arthritis, anxiety, also have the report in terms for the treatment of cancer of pancreas, but individually
The therapeutic effect using cannabidiol (CBD) is unsatisfactory.Therefore developing new activity high, the medicine that toxic and side effects is little shows
Obtain the most necessary.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of prepare with industrial hemp for primary raw material
The pharmaceutical composition for the treatment of cancer of pancreas.
The purpose of the present invention is achieved by the following technical programs.
Except as otherwise noted, percent of the present invention is mass percent.
A kind of medicine treating cancer of pancreas, it is characterised in that be made up of the raw material blending of following weight parts: industrial hemp fire
Fructus Cannabis extract 0.3 part～99.7 parts, industrial hemp Urtica cannabina L. element 99.7 parts～0.3 part.
The raw material composition of described treatment pancreatic cancer drug is preferably industrial hemp Fructus Cannabis extract 40 parts and industry is big
Fiber crops Urtica cannabina L. element 60 parts.
Wherein, described industrial hemp Fructus Cannabis extract is prepared by the following method and forms:
(1) ripe industrial hemp Fructus Cannabis is taken, drying, remove impurity, standby after pulverizing；
(2) under the conditions of 20～85 DEG C, with ethanol to pulverize Fructus Cannabis material extract, concentration of alcohol be 95%～
100% (V/V), solid-liquid ratio is 1:5～1:20；
(3) leach lixiviating solution, after concentrating under reduced pressure, be industrial hemp Fructus Cannabis extract.
When industrial hemp Fructus Cannabis being extracted with ethanol, following various ways can be used to carry out: as soaked under room temperature
Carry, every batch materials extraction 2 times, each 7～10 days；Under the conditions of 60～85 DEG C, heating extraction 2 times, each 1～3 hour；Ultrasonic
Ripple assisted extraction, ultrasonic frequency 30～60kHz, power 100～1000W, extraction time 30～60min, extraction temperature 25～
50℃；Also other prior aries such as microwave radiation exaraction can be used.
Described industrial hemp Urtica cannabina L. element is prepared by the following method and forms:
(1) take the flower of industrial hemp, leaf, fiber crops bran or the mixture of three, drying, remove impurity, be crushed to 10～60 mesh；
(2) supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is put into supercritical carbon dioxide extraction
During fetching is put, control extraction temperature 40～50 DEG C, extraction time 30～90min, extracting pressure 25～35Mpa, carbon-dioxide flow
Amount 40kg/h, extract is collected in separating still outlet；
(3) the extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, washing steps is 1～3
Secondary；
(4) eluent is collected, concentrating under reduced pressure, vacuum drying, i.e. obtain industrial hemp Urtica cannabina L. element after pulverizing.
The flower of described industrial hemp, leaf, the optimum ratio of fiber crops bran three's mixture are 1:3:2.
Common Folium Cannabis, Flos Cannabis are respectively provided with toxicity (containing the extremely unreal material of tetrahydrocannabinol THC marijuana hemp).For row
Except the toxicity of crude drug, present invention preferably employs the flower of industrial hemp kind " cloud fiber crops No. 1 " of Yunnan growth, leaf, fiber crops bran
With Fructus Cannabis as raw material.By China's relevant legal documents regulation, " cloud fiber crops No. 1 " can only be planted within the border in Yunnan, and its flower,
Leaf, fiber crops bran can only be processed within the border in Yunnan.
The pharmaceutical composition of the present invention can make different pharmaceutical preparation, including oral agents and injection, wherein mouth further
Taking agent and include capsule, oral liquid, tablet, drop pill, granule etc., injection includes injection dosage form and freeze-dried powder injection
Type etc..When preparing oral formulations, available auxiliary type agent can be that starch, dextrin or cyclodextrin, sucrose, stearate etc. are normal
Rule filler.Lyophilized injectable powder can be prepared by methods such as aseptic spray drying, low-temperature vacuum drying, lyophilizations.Each system
The later stage preparation technology of agent and equipment all belong to the routine techniques of pharmaceutical field, and this is not construed as limiting by the present invention, therefore at this most in detail
State.
The pharmaceutical composition of the present invention has the effect of clear and definite treatment cancer of pancreas.Experiment finds, this drugs against tumor is made
With being significantly higher than cannabidiol.Clinical observation finds, the medicine of the present invention can reduce lump, effectively controls cancer cell metastasis and expands
Dissipating, anticancer grows, for cancer anticancer while, can enhancing human body immunity power, alleviate patient suffering, stablize the state of an illness, prolong
Long life cycle and the ratio of increase clinical cure patient, and remaining cancerous cell relapse and metastasis can be substantially reduced, action effect is good
In cannabidiol.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but embodiment is not to the technology of the present invention side
The restriction of case.
Embodiment 1
Use flower, leaf, fiber crops bran and the Fructus Cannabis of industrial hemp kind " cloud fiber crops No. 1 " of Yunnan growth as raw material.
Take maturation industrial hemp Fructus Cannabis, drying, remove impurity, standby after pulverizing；With ethanol to pulverize Fructus Cannabis material extract (
Under the conditions of 60～85 DEG C, heating extraction 2 times, each 1～3 hour), concentration of alcohol is 95%～100% (V/V), and solid-liquid ratio is
1:5～1:20；Leach lixiviating solution, after concentrating under reduced pressure, be industrial hemp Fructus Cannabis extract.
Take the flower of industrial hemp, leaf, the mixture of fiber crops bran 1:3:2 mass ratio, drying, remove impurity, be crushed to 10～60 mesh；
Supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is put in supercritical carbon dioxide extraction apparatus, control
Extraction temperature 40 processed～50 DEG C, extraction time 30～90min, extracting pressure 25～35Mpa, carbon dioxide flow 40kg/h, point
Extract is collected from still outlet；The extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, washing steps
It it is 1～3 time；Collect eluent, concentrating under reduced pressure, vacuum drying, after pulverizing, obtain industrial hemp Urtica cannabina L. element.
Take industrial hemp Fructus Cannabis extract 40 parts, industrial hemp Urtica cannabina L. element 60 parts, mixing, obtain medicine B of the present invention.
Embodiment 2
Repeat embodiment 1, have following difference: when industrial hemp Fructus Cannabis being extracted with ethanol, soak under room temperature
Carry, every batch materials extraction 2 times, each 7～10 days.Take the flower of industrial hemp, leaf, the mixture conduct of fiber crops bran 1:1:1 mass ratio
The extraction raw material of industrial hemp Urtica cannabina L. element.
Take industrial hemp Fructus Cannabis extract 0.3 part, industrial hemp Urtica cannabina L. element 99.7 parts, mixing, obtain medicine A of the present invention.
Embodiment 3
Repeat embodiment 1, have following difference: when industrial hemp Fructus Cannabis being extracted with ethanol, use ultrasonic
Ripple assisted extraction, ultrasonic frequency 30～60kHz, power 100～1000W, extraction time 30～60min, extraction temperature 25～
50℃.Take the flower of industrial hemp, leaf, fiber crops bran 3:2:1 mass ratio mixture as industrial hemp Urtica cannabina L. element extraction raw material.
Take industrial hemp Fructus Cannabis extract 99.7 parts, industrial hemp Urtica cannabina L. element 0.3 part, mixing, obtain medicine C of the present invention.
Embodiment 4
Example 1 gained medicine 100 grams (crosses 80 mesh sieves), adds 60 grams of microcrystalline Cellulose, crosses 80 mesh sieve three times, mixing
Uniformly, spray into 95% ethanol solution, soft material processed, cross 40 mesh sieves and pelletize, 60 DEG C of dry half an hour, be sub-packed in 3# capsule, plastic-aluminum
Composite packaging, prepares treatment pancreatic cancer drug capsule.
Embodiment 5
Example 2 gained medicine, admixture doses 5～the dried starch of 20% and 1～the magnesium stearate etc. of 5%, through mixed
Close, pelletize, be dried, tabletting, prepare treatment pancreatic cancer drug tablet.
Embodiment 6
The adjuvants such as Example 3 gained medicine, adds sucrose water and the preservative of convention amount, stabilizer.Filtration, sterilizing,
It is distributed in 10mL bottle, makes treatment pancreatic cancer drug oral liquid.
Embodiment 7
Example 1 gained medicine, add water for injection dissolve, add 2.0 ‰ activated carbons, stirring, filter, continue with
0.45 μm, 0.22 μm microporous filter membrane classified filtering, supplement water for injection, be sub-packed in cillin bottle, lyophilization, recharge high-purity
Nitrogen, jumps a queue, gland, packaging, prepares treatment pancreatic cancer drug injection.
Application Example 1 present invention therapeutical effect evaluation to mouse pancreas cancer
Human pancreas cancer cell strain Patu 8988 is put in the RPMI-1640 complete medium containing 10% and cultivate.Take the logarithm
The human pancreas cancer cell strain of trophophase, by every 5 × 106Individual tumor cell inoculation, at nude mouse axillary fossa, sets up tumor model.
Take modeling successful nude mouse 60, measure gross tumor volume, be randomly divided into 3 groups, often group 20, i.e. normal saline
Group, A, B, C group of the present invention and cannabidiol group.Normal saline group subcutaneous injection gives normal saline；Of the present invention group of cannabidiol
Group and cannabidiol group equal subcutaneous injection 2mg/kg.Every treated animal, is given daily 1 time, successive administration 12 days, measures swollen after administration
Tumor volume, calculates tumour inhibiting rate, and adds up during each treated animal is administered and be administered the mortality rate terminating in latter 10 days.Result sees below
Table.
Table 1: respectively organize tumour inhibiting rate (%) and each treated animal mortality rate (%) after administration
Experimental result shows: antitumor action of the present invention is significantly higher than cannabidiol.The medicine of the present invention has significantly
Treatment cancer of pancreas effect.
The clinical observation of Application Example 2 Drug therapy of the present invention cancer of pancreas
1, case packet and therapeutic scheme: by cancer of pancreas case 300 example, the maleest 176 examples, female 124 example, the age was from 31 years old
～76 years old, patient is randomly divided into of the present invention group, chemotherapy group and cannabidiol group；
Cannabidiol group 100 people, male 61 people, female 39 people.Capsule that oral cannabidiol makes (cannabidiol 100 grams,
Make 1000), three times a day, each 6, it was 1 course for the treatment of with one month, serve on 1-3 the course for the treatment of.
Chemotherapy group 100 people, male 59 people, female 41 people, chemotherapeutics selects cisplatin (CDDP) 30mg/M2d1-3, gemzar
1000mg/M2d1,8,15, fluorouracil (5-Fu) 500mg/M2d1-5, select 2 kinds or 3 kinds of drug combinations therein during chemotherapy,
Intravenously administrable, 28 days is a cycle.
Of the present invention group of 100 people, male 56 people, female 44 people, capsule (the B present invention that the oral B present invention of the present invention makes
100 grams, make 1000), three times a day, each 6, it was 1 course for the treatment of with one month, serve on 1-3 the course for the treatment of.
All patient radiation all confirm through pathology before treating, and all have x-ray to take the photograph sheet, CT scan or nuclear magnetic resonance check confession
Clinical TNM by stages, checks before all doing chemotherapy by clinical criteria and confirm without chemicotherapy contraindication before chemotherapy, and all patients are all without turning
Move cancer of pancreas (MO).
International cancer of pancreas TNM by stages with clinical stages:
International cancer of pancreas TNM (UICC, 1987) by stages, T refers to primary tumo(u)r situation, and N refers to lymph metastasis situation, and M refers at a distance
Transfer case.
(1) primary tumo(u)r (T) is by stages:
Tx: can not judge；T0: without primary tumo(u)r evidence；T1: primary swollen without departing from pancreas；T1a: tumor≤2cm；T1b:
Tumor ＞ 2cm；T2: tumor invading duodenum, biliary tract or pancreas surrounding tissue；T3: tumor invading stomach, spleen, colon, big blood
Pipe.
(2) zonule lymph node (N) is by stages:
Nx: can not judge；NO: regional lymph nodes is without transfer；Nl: have regional lymph node metastasis；
(3) metastasis (M) is by stages:
Mx: can not judge；MO: without metastasis；Ml: have metastasis.
Clinical stages
The I phase: T1NO MO；T1NX MO；TX NO MO；TX NX MO.
The II phase: T2NO MO；T2NX MO；T3NO MO；T3NX MO.
The III phase: any T, N1, MO:.
The IV phase: any T, any N, Ml.
2, evaluation criteria: according to WHO treatment malignant tumor evaluation criteria evaluation curative effect, point complete incidence graph: all visible diseases
Become and be wholly absent at least 4 weeks；Part is alleviated: tumor size is estimated to reduce >=50% at least 4 week；Unchanged: without significant change extremely
Few 4 weeks, stable including pathological changes, tumor size is estimated to expand less than 25%, reduces less than 50%；Pathological changes extends: new focus occurs
Or original pathological changes estimates to expand ＞ 25%；4 ranking pancreas portion's primary tumors and the change of Metastatic Lymph Nodes gross tumor volume.
3, result of the test:
According to above-mentioned WHO evaluation criteria, drug treatment is after 4 months respectively, carries out short term effect statistical effect, the results are shown in Table
2。
Table 2: each group short term effect tracking table record
By table 2, the medicine of the present invention can be obviously reduced lump, effectively controls cancerous cell diffusion, increases clinic
Cure the ratio of patient, and summed up and regularly x-ray, CT or ultrasound diagnosis by clinical observation, patient's patient's condition inquiry every day
Deng, determine the medicine of the present invention can quickly be mitigated or eliminated that epigastrium distension is uncomfortable or distending pain, jaundice, tired, loss of appetite,
Become thin, suffer from diarrhoea or the symptom such as constipation, alleviate patient suffering, stablize the state of an illness；Effect is better than cannabidiol and chemotherapy.
All patients are carried out long-term follow record, and adds up survival number respectively and deposit when 1 year, 2 years, 3 years and 5 years
Motility rate, concrete data are shown in Table 3.
Table 3: each group long-term survival rate follows the tracks of survival number and survival rate
| Group | 1 year | 2 years | 3 years | 5 years |
| Cannabidiol group | 48 (48%) | 36 (36%) | 27 (27%) | 19 (19%) |
| Chemotherapy group | 23 (23%) | 10 (10%) | 2 (2%) | 0 (0%) |
| Of the present invention group | 65 (65%) | 54 (54%) | 40 (40%) | 34 (34%) |
By table 3, the medicine of the present invention can significantly improve the life span of Pancreas cancer patients, improves clinical cure
The ratio of patient；Therapeutic effect is better than cannabidiol and chemotherapy.
Claims (6)
1. the medicine treating cancer of pancreas, it is characterised in that be made up of the raw material blending of following weight parts: industrial hemp Urtica cannabina L.
Core extract 0.3 part～99.7 parts, industrial hemp Urtica cannabina L. element 99.7 parts～0.3 part.
The medicine for the treatment of cancer of pancreas the most according to claim 1, it is characterised in that: the raw material composition of described medicine is preferably
Industrial hemp Fructus Cannabis extract 40 parts and industrial hemp Urtica cannabina L. element 60 parts.
The medicine for the treatment of cancer of pancreas the most according to claim 1, it is characterised in that: described industrial hemp Fructus Cannabis extracts
Thing is prepared by the following method and forms:
(1) ripe industrial hemp Fructus Cannabis is taken, drying, remove impurity, standby after pulverizing；
(2) under the conditions of 20～85 DEG C, extracting pulverizing Fructus Cannabis material with ethanol, concentration of alcohol is 95%～100% (V/
V), solid-liquid ratio is 1:5～1:20；
(3) leach lixiviating solution, after concentrating under reduced pressure, be industrial hemp Fructus Cannabis extract.
The medicine for the treatment of cancer of pancreas the most according to claim 1, it is characterised in that: described industrial hemp Urtica cannabina L. element passes through
Following methods is prepared from:
(1) take the flower of industrial hemp, leaf, fiber crops bran or the mixture of three, drying, remove impurity, be crushed to 10～60 mesh；
(2) supercritical carbon dioxide extraction: the above-mentioned industrial hemp raw material crushed is put into supercritical carbon dioxide extraction dress
In putting, control extraction temperature 40～50 DEG C, extraction time 30～90min, extracting pressure 25～35Mpa, carbon dioxide flow
40kg/h, extract is collected in separating still outlet；
(3) the extract ethanol elution of 95%～100% (V/V) of 0.2～10 times of volume, washing steps is 1～3 time；
(4) eluent is collected, concentrating under reduced pressure, vacuum drying, i.e. obtain industrial hemp Urtica cannabina L. element after pulverizing.
The medicine for the treatment of cancer of pancreas the most according to claim 4, it is characterised in that: the flower of described industrial hemp, leaf, fiber crops
The optimum ratio of bran three's mixture is 1:3:2.
6. according to the medicine of the treatment cancer of pancreas described in claim 1 or 2 or 3 or 4 or 5, it is characterised in that: described industry is big
The kind of fiber crops is preferably " cloud fiber crops No. 1 ".
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| CN105505565A (en) * | 2015-12-28 | 2016-04-20 | 贵州航天乌江机电设备有限责任公司 | Method for extracting industrial hemp oil rich in cannabidiol |
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| CN105505565A (en) * | 2015-12-28 | 2016-04-20 | 贵州航天乌江机电设备有限责任公司 | Method for extracting industrial hemp oil rich in cannabidiol |
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| 赵翾等: "响应面法优化火麻仁黄酮提取工艺", 《食品科学》 * |
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