CN104322617A - Biscuit assisting in regulating blood sugar level and preparation method thereof - Google Patents

Abstract

The invention provides a biscuit for assisting in lowering blood sugar. The biscuit comprises the following raw materials: flour, traditional Chinese medicine additives, vegetable oil, milk, water and eggs. The raw materials of traditional Chinese medicine additives used in the biscuit raw materials include: Peilan, perilla, hawthorn, schisandra, rehmannia root, Jiaogulan, Patrinia, Zhishouwu, cassia, salvia, tangerine peel, kudzu root, sealwort, yam, Alisma , red peony root, Ophiopogon japonicus, Prunella vulgaris. This kind of food therapy is quite different from taking bitter-tasting medicines. It is not easy to make people tired and difficult to adhere to like medicines. It is easy to accept and can be used for a long time. It is especially suitable for the conditioning and treatment of chronic diseases. The traditional Chinese medicine additive of the invention contains fatty acids, various alcohols, saponins, etc., can lower blood sugar and blood lipids, reduce blood sugar and fat deposition in blood vessels, and can be used for auxiliary treatment of diabetes caused by high blood sugar.

Description

A biscuit for assisting in lowering blood sugar and preparation method thereof

technical field

The invention relates to a health food containing raw materials derived from plants, animals or minerals, in particular to a biscuit which assists in lowering blood sugar and a preparation method thereof.

Background technique

The fast-paced social life and intense competitive work pressure pose a serious threat to the physical and mental health of modern people. In addition, the long-term diet is unreasonable, that is: refined grains completely replace coarse grains, and a large number of three highs (high heat, high protein, High fat), food intake of more than three (more preservatives, more flavor enhancers, more hormones) food and the accumulation of pesticides and fertilizers in the body, coupled with air and water pollution and less exercise, so In the long run, the so-called "modern civilization diseases" such as three highs (hypertension, hyperglycemia, and hyperlipidemia), cardiovascular and cerebrovascular diseases, and cancer will increase rapidly, and will continue to rejuvenate, seriously endangering human health and life.

China's traditional dietary structure is very reasonable, but the dietary structure of Chinese people is becoming more and more Westernized. According to data, from 1997 to 2012, among the top ten categories of food consumed by Chinese residents, the consumption of grain and soy food decreased by 12.6% and 6.8% respectively, sugar food increased by 42.1%, vegetable oil, Consumption of meat, poultry and eggs each rose more than 20 percent. The emergence of this situation is related to the proliferation of foreign fast food. Most of the foreign fast food is fried, baked and processed food, and the proportion of meat is very high. This wrong orientation of "meat is nutritious" is an important reason for the westernization of the diet structure. The reason is that in fact, about 60% of food calories come from carbohydrates, 25% from fat, and 12% to 15% from protein. This is the ideal dietary composition ratio. Foreign fast food is characterized by three highs and three lows, namely high calories, high fat and high protein, low minerals, low vitamins and low dietary fiber. Due to the serious imbalance of nutrition, the international nutritional circles call foreign fast food energy bombs and junk food. The traditional Chinese diet pays attention to balance, and puts forward that "the five grains should be nourished, and the loss of beans will be bad; the five animals should be beneficial, and the excess will be harmful; The dietary principle of "and counting". Described in modern language, it is necessary to maintain the biodiversity of food sources, mainly cereals; eat more vegetables, fruits and potatoes; eat enough beans and their products every day; fish, poultry, meat, eggs, etc. Animal foods such as milk and milk should be eaten in moderation. Food therapy has a wide range of adaptations, mainly for sub-healthy people, followed by patients. As an auxiliary means of drugs or other treatment measures, it is naturally accepted along with daily diet.

"Three highs" refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia. Often accompanied by obesity. They are "diseases of wealth" derived from modern society, and they can exist independently or be related to each other. For example, people with diabetes are likely to suffer from high blood pressure or hyperlipidemia at the same time, and hyperlipidemia is the main factor in the formation and development of arteriosclerosis. The poor elasticity of blood vessels in patients with arteriosclerosis aggravates the increase in blood pressure, so the "three highs" are formed in the later stage ". According to statistics on what are the three highs, among the top ten causes of death in China, the mortality rate related to metabolic diseases is as high as 35.7%, and the number of deaths related to the "three highs" also accounts for 27% of the total death toll. Hyperlipidemia can cause vascular embolism; high blood pressure can cause cerebral hemorrhage and cerebrovascular rupture; high blood sugar can cause diabetes.

The World Health Organization once clearly stated that the first line of defense to prevent cardiovascular disease is to reduce and control the "three highs". Many diabetics are accompanied by hyperlipidemia, so people usually call diabetes and hyperlipidemia sister diseases, and think that hyperlipidemia is a secondary disease of diabetes. According to statistics, about 40% of diabetic patients have lipid metabolism disorders. It is characterized by increased triglycerides and decreased high-density lipoproteins. The reason for the increase of blood lipids caused by diabetes is that when insulin is insufficient in diabetic patients, the activity of lipase in the body is reduced, so blood lipids are prone to increase. On the other hand, diabetes itself is accompanied by disorders of fat, protein, water, and electrolytes in addition to glucose metabolism disorders. Free fatty acids are often mobilized from the fat depot, which increases the concentration of triglycerides and free fatty acids in the blood. On the other hand, people with type II diabetes eat too much and exercise less, which promotes increased lipid synthesis in the body, which is also the cause of increased blood lipids. Obese people with hyperlipidemia, due to the relative decrease in the number of insulin receptors, will develop insulin resistance and easily induce diabetes. Those with elevated blood lipids are also prone to cardiovascular and cerebrovascular complications.

The smell of traditional Chinese medicine is bitter, and many people do not want to take it for a long time; How to maximize the efficacy of traditional Chinese medicine without harming the human body, and obviously improve the taste so that people can accept it is a problem that we urgently need to solve. Traditional Chinese medicine contains a large number of safe and effective active substance health care products, which can greatly reduce blood sugar and lipids, and has always been the key to solving problems that people expect. Many traditional Chinese medicines contain fatty acids, bogus alcohol, irritant and soap, etc., which can lower blood sugar, clear blood lipids, reduce fat deposition in blood vessels, and can be used to treat atherosclerosis. Now the market urgently needs to develop a kind of healthy food that is nontoxic, can be completely absorbed by organisms, and lowers blood sugar.

It is generally believed that food is an edible substance that provides the human body with various nutrients needed for growth, development and healthy survival. In other words, the most important thing about food is nutrition. In fact, Chinese medicine has long recognized that food can not only provide nutrition, but also cure diseases. For example, Zhang Xichun, a modern physician, once pointed out in "Medical Hearts in Shenxilu": Food "can not only cure the disease, but also satisfy the hunger; not only satisfy the hunger, but also palatable. If it is used to the symptoms, the disease will gradually heal, that is, it is not symptomatic." , and there is no other trouble." With the development of society, people pay more and more attention to the way of keeping in good health. Many foods suitable for health preservation have also been promoted. The common ones are multigrain powder, multigrain porridge, medicated diet and so on. Food therapy has a wide range of adaptations, mainly for sub-healthy people, followed by patients. As an auxiliary means of drugs or other treatment measures, it is naturally accepted along with daily diet.

Contents of the invention

The technical problem to be solved by the present invention is that the research and treatment of diabetes and hyperlipidemia by Western medicine have achieved great results, but the liver and kidney function, digestive tract symptoms, muscle damage and rebound after drug withdrawal caused by long-term medication The effect remains a difficult problem for treatment. In view of the characteristics of traditional Chinese medicine based on dialectical treatment and the advantages of less toxic and side effects of traditional Chinese medicine, the health care treatment of traditional Chinese medicine has attracted widespread attention. Drug therapy mainly uses drugs, which are strong in nature and have been called "poison" since ancient times. They are mainly designed for curing diseases. Therefore, drug therapy has a limited scope of application and is mainly aimed at patients. It is an important means of treating and preventing diseases. If medicines are used casually, laxatives for deficiency syndromes, tonics for excess syndromes, warm medicines for heat syndromes, and cold and cool medicines for cold syndromes, not only cannot cure the disease, but will aggravate or even worsen the original condition. Therefore, the medication must be very cautious. Food therapy is based on food, which can not only achieve the purpose of health care, physical fitness and disease prevention, but also give people sensory and spiritual enjoyment, so that people can unconsciously achieve the purpose of disease prevention and treatment while enjoying the delicious food. . This kind of natural therapy is quite different from taking bitter medicines. It is not as easy to take as medicine and is difficult to adhere to. It is easy to accept and can be used for a long time. It is especially suitable for the conditioning and treatment of chronic diseases.

How to extract the active ingredients of traditional Chinese medicine, and then use it in diet therapy, "When patients take it, it not only cures the disease, but also satisfies their hunger; Suffering". It is a problem we urgently need to solve.

In order to solve the above-mentioned technical problems, the present invention provides a biscuit that assists in lowering blood sugar, and the biscuit includes the following raw materials: flour, traditional Chinese medicine additives, vegetable oil, milk, water, and eggs; the preparation method is: mixing the raw materials evenly, forming , baking, cooling, packaging, finished product.

The biscuit for assisting hypoglycemia, the raw material flour used in the biscuit is made by mixing buckwheat flour and wheat flour at a ratio of 1:1; the ratio of the traditional Chinese medicine additive to flour is 1:5.

The biscuit that assists in lowering blood sugar, the raw materials of the traditional Chinese medicine additives used in the raw materials of the biscuit include: Peilan, perilla, hawthorn, Schisandra chinensis, rehmannia glutinosa, Gynostemma pentaphyllum, Patrinia, Zhishouwu, cassia seed, salvia miltiorrhiza, tangerine peel , Pueraria root, Polygonatum, Yam, Alisma, Radix Paeoniae Rubra, Ophiopogon japonicus, Prunella vulgaris.

For the biscuit that assists in lowering blood sugar, the parts by weight of the traditional Chinese medicine additive used in the biscuit raw material can be: 10-20 parts of perilla, 10-20 parts of perilla, 10-20 parts of hawthorn, 10-20 parts of schisandra, 10-20 parts of raw rehmannia, 10-20 parts of Jiaogulan, 10-20 parts of Patrinia, 10-20 parts of Shouwu, 10-20 parts of cassia seed, 10-20 parts of salvia, 10-20 parts of tangerine peel, 10-20 parts of kudzu root 20 parts, Polygonatum 10-20 parts, Chinese yam 10-20 parts, Alisma 10-20 parts, Radix Paeoniae Rubra 10-20 parts, Ophiopogon japonicus 10-20 parts, Prunella vulgaris 10-20 parts.

For the biscuit that assists in lowering blood sugar, the parts by weight of the traditional Chinese medicine additive used in the raw material of the biscuit can also be: 10-15 parts of perilla, 10-15 parts of perilla, 10-15 parts of hawthorn, and 10-15 parts of schisandra . ～15 parts, Polygonatum 10～15 parts, Chinese yam 10～15 parts, Alisma 10～15 parts, Radix Paeoniae Rubra 10～15 parts, Ophiopogon japonicus 10～15 parts, Prunella vulgaris 10～15 parts.

In order to solve the above-mentioned technical problems, the present invention also provides a preparation method of a traditional Chinese medicine additive used in biscuits that assist in lowering blood sugar, wherein the preparation steps of the traditional Chinese medicine additive include:

a. Put all the raw materials into ethanol which accounts for 5-10 times of its mass and extract twice under reflux as component 1;

b. Put the dregs of the above-mentioned extracted crude drug into water and heat and reflux to extract twice, as component 2;

c. Combining the above two extracts, component 1 and component 2, concentrated into an extract, sterilized and made into powder.

In the step a, all raw materials can be put into 5-10 times the amount of ethanol, soaked for 1-2 hours, heated and extracted twice, each time for 1-2 hours, the supernatant is removed, and the extract is combined, 100-120 After filtering, the two extracts were combined and left still, the ethanol was recovered under reduced pressure, and concentrated to a concentration of 0.6g crude drug/mL. After suction filtration, the relative density of the filtrate was about 1.08 at 20°C; the pressure was reduced to 0.03 -0.08MPa, the temperature is kept at 60-80°C, concentrated to a relative density of 1.20, and the temperature is 60°C-70°C, as component 1.

In the step b, the medicinal dregs extracted in the above steps can be put into water that accounts for 10 times its volume, soaked for 1-2 hours, heated and extracted twice for 1-2 hours each time, combined with the extracts, and removed after standing Then put the supernatant into a decompression concentration tank, recover ethanol under decompression, concentrate until the concentration of the medicinal solution is 0.1g crude drug/mL, suction filter until the relative density of the filtrate is 1.06 at 20°C, and become component 2 .

In the step c, component 1 and component 2 can be combined, placed in a double-effect vacuum concentrator, concentrated to a concentrated solution with a relative density of 1.25 at 90°C, and refrigerated at 0-5°C for 24 hours; Add 0.3% filter aid diatomaceous earth to the refrigerated liquid, filter, put the filtrate into a double-effect vacuum concentrator, concentrate to contain 0.2g of crude drug per 1ml; concentrate into an extract, put it into an oven and dry it into a powder, Then ultraviolet sterilized canning.

In order to solve the above technical problems, the present invention further provides a preparation method of a traditional Chinese medicine additive used in a biscuit that assists in lowering blood sugar. , chopped and passed through a 150-180 mesh fine sieve, the fine powder after sieving is ready for use, the coarse particles are put into an acid and alkali resistant dipping pot, and soaked with ethanol above 70 degrees for 10-15 days at room temperature, and the soaked liquid and The dregs are squeezed and filtered, and the filtrate is taken after separation; the filtrate is heated and concentrated to a paste, dried in an oven, ground into a fine powder after cooling, and mixed with the sieved fine powder to form a powder, which is sterilized by ultraviolet rays and packed bottle.

Because the present invention is mainly used for the prevention and treatment of hyperglycemia, which is a chronic disease related to multiple factors, the course of the disease is long, and long-term medication is needed to achieve good results. Therefore, it should be taken, carried, and convenient to use. The diet can improve the health care effect. At present, Western medicine has made great achievements in the research and treatment of diabetes and hyperlipidemia, but the liver and kidney function, digestive tract symptoms, muscle damage and rebound effect after drug withdrawal caused by long-term drug use are still difficult problems in treatment. Decoction is a traditional dosage form of traditional Chinese medicine, which has the advantages of convenient addition and subtraction according to the disease, but it is inconvenient to decoct, carry and use, and the ingredients are not completely decocted, and the taste is poor, so it is not suitable for the medication habits of modern people. Drug therapy mainly uses drugs, which are strong in nature and have been called "poison" since ancient times. They are mainly designed for curing diseases. Therefore, drug therapy has a limited scope of application and is mainly aimed at patients. It is an important means of treating and preventing diseases. If medicines are used casually, laxatives for deficiency syndromes, tonics for excess syndromes, warm medicines for heat syndromes, and cold and cool medicines for cold syndromes, not only cannot cure the disease, but will aggravate or even worsen the original condition. Therefore, the medication must be very cautious. Food therapy is based on food, which can not only achieve the purpose of health care, physical fitness and disease prevention, but also give people sensory and spiritual enjoyment, so that people can unconsciously achieve the purpose of disease prevention and treatment while enjoying the delicious food. . This kind of natural therapy is quite different from taking bitter medicines. It is not as easy to take as medicine and is difficult to adhere to. It is easy to accept and can be used for a long time. It is especially suitable for the conditioning and treatment of chronic diseases. The active ingredients of traditional Chinese medicine are extracted, and then used in diet therapy to make it "patients take it, not only cure the disease, but also satisfy the hunger; not only satisfy the hunger, but also palatable, use it to the symptoms, and the disease will gradually heal. He suffers".

Detailed ways

When fasting (no sugar or any sugar-containing food intake within 8 hours) blood sugar is higher than the normal range, it is called hyperglycemia. L, can also be called hyperglycemia. Hyperglycemia is not a diagnosis of a disease, but a judgment of blood glucose monitoring results. Blood glucose monitoring is a temporary result, and hyperglycemia is not completely equal to diabetes. Occasional hyperglycemia. If you eat a lot of sweets before the blood sugar test, of course there will be high blood sugar results. So check out is high blood sugar, don't worry too much. After a period of time, check your blood sugar results again.

Bad living habits and environment. Most young people nowadays like fast food like KFC, but don't like vegetables and fruits. Long-term eating habits may lead to high blood sugar. Negative air ions are natural factors in the air, which can effectively reduce hyperglycemia. However, the pollution of the environment has led to a sharp decrease in the content of negative oxygen ions in the air, and the lack of negative oxygen ions in the human body is also an important cause of hyperglycemia. Coronary heart disease, etc. are closely related to high blood sugar. Therefore, once hyperglycemia is diagnosed, one should try to understand what causes hyperglycemia, so that symptomatic treatment can be done, and the work of preventing and treating hyperglycemia can be done well.

At present, people with diabetes are getting younger and younger, and even children with diabetes have appeared. Therefore, what diabetic patients must know is that high blood sugar should be treated as soon as possible.

Food therapy and drug therapy are very different. One of the most notable characteristics of food to cure diseases is that it "cures diseases when they are sick, and strengthens the body without diseases", and it basically has no toxic and side effects on the human body. That is to say, using the biased characteristics of food (grains, fruits, vegetables) in terms of nature and taste can be used in the treatment or adjuvant treatment of certain diseases in a targeted manner. Physical and mental recovery, but food is food after all, it contains various nutrients necessary for the human body, mainly to make up for the continuous consumption of yin and yang, qi and blood. Therefore, even if the syndrome differentiation is inaccurate, food will not cause too much harm to the human body. As the famous doctor Zhang Xichun said in "Medical Hearts and Canxi Records", "Diet therapy patients take it not only cures the disease but also satisfies the hunger. ". Therefore, food therapy has a wide range of adaptations, mainly aimed at sub-healthy people, followed by patients. As an auxiliary means of drugs or other treatment measures, it is naturally accepted along with daily diet.

Drug therapy mainly uses drugs, which are strong in nature and have been called "poison" since ancient times. They are mainly designed for curing diseases. Therefore, drug therapy has a limited scope of application and is mainly aimed at patients. It is an important means of treating and preventing diseases. If medicines are used casually, laxatives for deficiency syndromes, tonics for excess syndromes, warm medicines for heat syndromes, and cold and cool medicines for cold syndromes, not only cannot cure the disease, but will aggravate or even worsen the original condition. Therefore, the medication must be very cautious.

Food therapy is based on food, which can not only achieve the purpose of health care, physical fitness and disease prevention, but also give people sensory and spiritual enjoyment, so that people can unconsciously achieve the purpose of disease prevention and treatment while enjoying the delicious food. . This kind of natural therapy is quite different from taking bitter medicines. It is not as easy to take as medicine and is difficult to adhere to. It is easy to accept and can be used for a long time. It is especially suitable for the conditioning and treatment of chronic diseases.

Diabetes is equivalent to the category of quenching thirst in traditional Chinese medicine. Chinese yam is also known as Huaishan and Ganping. Slightly fragrant but not dry, it is an essential medicine for the lung and spleen. Pueraria lobata is sweet and pungent, can promote energy and clear yang, encourage stomach qi to ascend and produce body fluid to quench thirst. Ophiopogon japonicus is sweet, slightly bitter and cold, moistens the lungs and nourishes yin, clears the heart and relieves restlessness, and is effective for internal heat and quenching thirst caused by internal heat consumption. Huangjing Ganping can nourish yin and moisten the lungs, but also benefit qi. It is sweet and moist, enters the three meridians of the lung, spleen and kidney, and is good at nourishing yin. It is a good product for treating various syndromes of thirst. , It can be effective with a large amount of clothes alone. Salvia miltiorrhiza is bitter and slightly cold, specially enters the blood system, and its function is to promote blood circulation and stop blood circulation, and is an important medicine for stagnation of blood stasis. It can break old blood and replenish new blood. The whole prescription nourishes yin and moistens dryness, regulates blood and lowers blood sugar, and achieves results through whole body regulation.

Polygonatum is used as medicine with rhizomes. It has the functions of invigorating qi and nourishing yin, invigorating the spleen, moistening the lungs and benefiting the kidney. It is used to treat weak spleen and stomach, tiredness and fatigue, dry mouth and lack of food, dry cough due to lung deficiency, insufficient essence and blood, internal heat and thirst. Very effective for diabetes. Medicinal value: 1. Anti-pathogenic microorganism effect: In vitro tests show that Polygonatum water extract (1:320) has inhibitory effect on Salmonella typhi, Staphylococcus aureus, and acid-fast bacilli, and 2% Polygonatum in Sabouraud medium It has different degrees of inhibitory effect on common pathogenic fungi. 2. Effects on blood sugar: the blood sugar content gradually increased and then decreased after oral administration of Polygonatum extract to rabbits. Polygonatum extract significantly inhibits hyperglycemia induced by adrenaline. 3. Anti-fatigue effect: Polygonatum decoction 17.67% concentration 0.3ml/peritoneal injection can prolong the swimming time of mice. 4. Antioxidant effect: Polygonatum decoction at 20% concentration, 13ml/mouse, for 27 consecutive days, increased the activity of superoxide dismutase (SOD) in the liver of mice, and decreased the content of myocardial lipofuscin.

Perilla is a comprehensive cross-product, which is not only medicinal, but also a commonly used clinical medicine and edible. In the form of medicine, the stem is called Zigeng, the leaves are also called Su Ye, and the seeds are called Su Zi, Hei Su Zi, and Chi Su Zi, which are important components of Su Zi Jiang Qi Decoction. Dispelling cold and relieving the exterior, regulating qi and widening the middle. Indications for cold and fever, fear of cold, no sweat, chest tightness, cough, abdominal pain caused by crab poisoning, diarrhea, vomiting and other symptoms. When we did the experiment of Pleurotus ostreatus, we found that the effect of perilla bacterium was very good. It is cultivated all over the country, and it is wild in the provinces south of the Yangtze River, and it can be found by the village or roadside.

Ophiopogon japonicum (Ophitopogin japonicum (L.f) Ker.-Gawl.) is a medicinal herb of the genus Ophitopogin japonicum (L.f) Ker.-Gawl. in the Liliaceae family. Nature and flavor function: sweet, slightly bitter, cool, nourishing yin and promoting body fluid, moistening lung and relieving cough, clearing heart and eliminating troubles. Indications for febrile disease and body fluid injury, upset, thirst, dry throat and lung heat, cough, tuberculosis. Sweet, slightly bitter, slightly cold. GUIXIN, lung, stomach warp. [Functions and Indications] Nourishing yin and promoting body fluid, nourishing the lungs and clearing the heart. It is used for dry cough due to dryness of the lung, consumptive cough due to yin deficiency, sore throat due to obstruction of the throat, thirsty body fluid wound, internal heat quenching one's thirst, vexation and insomnia, intestinal dryness and constipation.

Yam is sweet in taste and flat in nature. Return spleen, lung, kidney channel. Functions and indications: Tonify the spleen and nourish the stomach, promote body fluid and benefit the lungs, invigorate the kidney and astringent essence. Used for insufficiency of the spleen, lack of food, persistent diarrhea, dyspnea and cough due to lung deficiency, spermatorrhea due to kidney deficiency, leukorrhea, frequent urination, deficiency-heat and quenching thirst. "Materia Medica Seeking Truth": "It should be used raw when used as a medicine for nourishing yin, and used as a medicine for nourishing the spleen and lungs." , long muscle, sweet and salty, and can benefit the kidney and strengthen yin.” In the study of experimental arthritis rats, the water extract of yam can significantly inhibit the denaturation effect of Cu2 + on gamma globulin, indicating that it has anti-arthritis role. The yam water extract can also eliminate urine protein, which can inhibit the production of mutant cells. Invigorate the middle and nourish Qi: Iron stick yam is rich in 18 kinds of amino acids, more than 10 kinds of trace elements, and other minerals, so it has the functions of strengthening the spleen and stomach, nourishing the lungs and kidneys, nourishing the middle and replenishing qi, strengthening the spleen and replenishing deficiency, strengthening the kidney and replenishing essence, It has the functions of benefiting the heart and calming the nerves. In Li Shizhen's "Compendium of Materia Medica", there is a saying that "invigorates the spleen, nourishes essence and strengthens the kidney, cures all kinds of diseases, and treats five labors and seven injuries". Diabetes and body fluid: Yam has the effect of quenching thirst: Chinese yam is often used alone or in combination with other medicines in the prescription of traditional Chinese medicine to treat consumptive thirst (diabetes).

Prunella vulgaris is cold in nature, sweet, pungent, and slightly bitter. It has the effects of clearing liver fire, dispelling stagnation and swelling, clearing away heat and detoxification, eliminating phlegm and relieving cough, cooling blood and stopping bleeding. It is suitable for lymphatic tuberculosis, goiter, mastitis, dizziness, Crooked mouth and eyes, muscle and bone pain, tuberculosis, metrorrhagia, leukorrhagia, acute infectious jaundice hepatitis and bacillary dysentery, etc. Modern pharmacological studies have shown that Prunella vulgaris has the effect of lowering blood pressure,

Patriniae Indications: heat-clearing and toxic substances removing; reducing swelling and draining pus; cooling blood to stop bleeding. Intestinal carbuncle; lung abscess; cough due to lung heat; enteritis; The rhizome is used as medicine, which has anti-inflammatory and diuretic effects, and can be used to extract aromatic oil.

Peilan feels summer-dampness; cold and heat headache; internal dampness; abdominal distension without hunger; nausea and vomiting; sweet and greasy in the mouth; disappearing. It is used for dampness and turbidity, nausea, nausea, sweet and greasy mouth, bad breath, excessive salivation, summer-heat-damp syndrome, head distension and chest tightness. "The Classic": Mainly benefit waterways, kill gu poison. "Zhai Gong Pao Shao Lun": Producing blood, regulating Qi and glory. "Bie Lu": Eliminate phlegm addiction in the chest.

Schisandra is sweet, sour, and warm in nature. Can replenish qi and promote body fluid, invigorate the kidney and nourish the heart, astringent and astringent. Contains sugar, fatty oil, volatile oil, malic acid, citric acid, tartaric acid, vitamin C and other ingredients. It can enhance the excitatory process of the central nervous system, and can also strengthen the inhibitory process to balance each other and improve the regulation of the cerebral cortex; it can increase work rate and reduce fatigue. It can regulate blood pressure and enhance heart function. It can stimulate breathing, and has expectorant and antitussive effects. It can promote bile secretion, reduce serum glutamate-alanine aminotransferase in patients with hepatitis, and has a certain protective effect on liver cells. It can still regulate the secretion of gastric juice, excite the uterus, improve vision and hearing, and improve the discrimination ability of skin receptors. Schisandra chinensis has similar adaptogenic effects as ginseng and eleuthero, but the effect is slightly weaker; it can also enhance the body's defense ability against non-specific stimuli. [Use] Used for qi deficiency and body fluid injury, fatigue and hyperhidrosis, shortness of breath and palpitations; wheezing and coughing caused by insufficient lung qi or deficiency of both lung and kidney, or prolonged wheezing and coughing, resulting in lung qi exhaustion; heart yin deficiency, palpitations, Insomnia and forgetfulness; weak kidney qi, nocturnal emission, frequent urination, or spleen and kidney deficiency, prolonged diarrhea. It is also used in modern times for anicteric and persistent chronic hepatitis.

Pueraria lobata (scientific name: Pueraria lobata) is a plant of the genus Pueraria in the Fabaceae family. Its root is the Chinese herbal medicine Puerariae Radix (Chinese medicine Latin name Puerariae Radix), also known as Luhuo, Huangjin, and Chicken Qigen. Diabetes, high blood pressure, angina pectoris, deafness, etc. Pueraria lobata is used for medicine. The flavonoids extracted from Pueraria lobata root and deoxynojirimycin extracted from mulberry leaves are combined to form a new substance, cics, which has the effects of lowering blood sugar, blood lipids, and anti-inflammation. Pueraria lobata has the functions of relieving exterior syndrome, reducing fever, producing body fluid, quenching thirst, and relieving diarrhea, and can improve symptoms such as neck stiffness, dizziness, and headache in patients with hypertension and diabetes. The active ingredients are daidzein, xanthoside and puerarin. Stem bark fiber is used for weaving and papermaking. It was widely used in ancient times, and kudzu clothes and kudzu scarves were civilian clothing, kudzu paper and kudzu ropes were also used for a long time, and kudzu powder was used to hangover.

Cassia seed is the seed of "Cassiae", which is a commonly used traditional Chinese medicine. Indications for hypertension, headache, dizziness, acute conjunctivitis, corneal ulcer, glaucoma, carbuncle, furuncle and sore. Make tea with its leaves, and middle-aged and elderly people drink it for a long time, which can make blood pressure normal and defecate unobstructed. Semen Cassiae is also known as "Returning Pupils". Semen Cassiae contains a variety of vitamins and is rich in amino acids, fats, carbohydrates, etc. In recent years, its health care function has been increasingly valued by people. Cassia seed has the functions of clearing liver-fire, dispelling rheumatism, benefiting kidney and improving eyesight, etc. Drinking cassia seed tea regularly can make blood pressure normal, defecate unobstructed, and prevent old eyes from blurring. Clinical experiments have proved that drinking cassia seed tea can clear the liver and improve eyesight, prevent blurred vision, lower blood pressure, lower blood fat, reduce cholesterol, etc. It has good curative effect on preventing coronary heart disease and high blood pressure; Prevention and treatment of night blindness and avoiding zinc deficiency in children. In addition, cassia seed tea's laxative function can also solve the problems of modern people's stomach and constipation. It can treat dry stools and help smooth defecation.

Alisma: good at diuresis and expelling dampness, expelling heat, used for dysuria, edema, fullness, stranguria, astringent pain, nocturnal emission, flaccidity and softness of ankles and knees; stir-fried Alisma, biased towards spleen and expelling dampness, used for phlegm, diarrhea and dysentery , dizziness. Alisma, Poria, and Polyporus; all three can infiltrate water and promote dampness, diuresis and reduce swelling, and often all three are used together; Alisma is cold in nature, can expel heat, and clear away fire; Poria can benefit the heart and spleen, and calm the mind; As for Polyporus, it can only diuresis and diuresis. Sweet in taste; light; cold in nature, returns to kidney; bladder meridian. Functions and indications: diuresis and dampness expelling; expelling heat and treating stranguria. Mainly dysuria; heat stranguria astringent pain; edema and fullness; diarrhea; phlegm retention dizziness; spermatorrhea.

Hawthorn contains a variety of vitamins, maslinic acid, tartaric acid, citric acid, malic acid, etc. It also contains flavonoids, lactones, sugars, proteins, fats, calcium, phosphorus, iron and other minerals. Digestion of fatty foods. Promote the secretion of gastric juice and increase gastric enzymes and other functions. Traditional Chinese medicine believes that hawthorn has the functions of eliminating accumulation and stagnation, astringent and dysentery, promoting blood circulation and removing stasis. Indications of food stagnation, fullness of the chest and diaphragm, hernia and blood stasis amenorrhea embolism. Hawthorn contains medicinal ingredients such as mountain terpenoids and brass, which have significant effects of dilating blood vessels and lowering blood pressure. It helps to relieve local congestion and has an auxiliary effect on bruises; the flavonoids, vitamin C, carotene and other substances contained in hawthorn can block and reduce the generation of free radicals, can enhance the body's immunity, and have anti-aging, Anti-cancer effect; Hawthorn has ingredients for relieving asthma, reducing phlegm, inhibiting bacteria, and treating abdominal pain and diarrhea.

Rehmannia glutinosa, the fresh or dried root tuber of Rehmannia glutinosa Libosch., a perennial herb of Scrophulariaceae. Clearing away heat, promoting body fluid, moistening dryness, smoothing intestines, breaking blood stasis, promoting new life, relieving pain, regulating menstruation, gold sores and blood stasis, cooling blood, and stopping bleeding; fresh rehmannia and raw rehmannia have different effects. Fresh Rehmannia glutinosa clears away heat and promotes body fluid, can stop bleeding and cool blood, and is often used for febrile diseases and Yin damage, hematemesis, sore throat, crimson tongue and polydipsia, spots and rashes, and epistaxis. Compared with fresh rehmannia glutinosa, rehmannia rehmannia cools blood and heat, can also produce body fluid, and nourish yin. It is mostly used to treat problems such as internal heat due to yin deficiency, bone steaming and labor heat, crimson tongue and polydipsia, and spot rashes. Habitat is cold in nature, and its function is to nourish yin and invigorate the kidney. Not only does it produce body fluid, quench thirst and cool serum heat, but it also has effects on blood metrorrhagia, irregular menstruation, fetal movement, constipation, etc. People with blood heat and Yin damage can take it regularly. If you want to treat febrile diseases, you can use raw land to make Qingying Decoction; if you are in the later stage of treating febrile diseases, because the residual heat has not been exhausted, you should use raw land to cook Qinghao Biejia Decoction; in addition, for blood heat and poison, For symptoms of purple and black spots, febrile disease with severe heat entering the camp and blood, you can take Sisheng Pills made from raw ground; generally, if you want to nourish yin and promote body fluid to treat internal heat, thirst and constipation, you should eat Zengye soup cooked with raw ground.

Gynostemma Gynostemma has been found by modern medical research. The main active ingredients of Gynostemma pentaphyllum are polysaccharides, flavonoids, saponins and trace elements. It is used in the treatment and health care of hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, and chronic respiratory inflammation (pharyngitis, gastroenteritis, etc.).

Danshen bitter, slightly cold. GUIXIN, Liver Channel. Dispelling blood stasis and relieving pain, promoting blood circulation to stimulate menstrual flow, clearing away heart-fire and relieving restlessness. For irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat arthralgia pain, sore swelling and pain, vexation and insomnia. It is used for sternocostal and hypochondriac pain, rheumatic arthralgia, lumps in the abdomen, swelling and pain of sores, pain from falls, irregular menstruation, amenorrhea dysmenorrhea, postpartum stasis and pain, etc. It is effective in treating sternocostal pain, lumps in the abdomen, irregular menstruation and amenorrhea. "Compendium" contains: Danshen, according to "Furen Ming Theory", Siwu Decoction can be used to treat women's diseases, regardless of prenatal and postpartum, and the amount of menstrual fluid, but Danshen powder is the same, and the indications are the same. Salvia miltiorrhiza can break old blood, replenish new blood, give birth to a fetus, stop stillbirth, stop stagnation in metrorrhagia, and regulate meridians. Tanshinone, the main component of Danshen, has the effects of dilating blood vessels, improving circulation, and relieving intravascular coagulation. It has the effect of promoting blood circulation and promoting blood circulation in the liver, which is beneficial to liver cell regeneration.

Tangerine peel is warm in nature, pungent in taste and bitter in taste. Go into spleen channel, stomach channel, lung channel. Regulates qi and invigorates the spleen, regulates the middle, dries dampness, and resolves phlegm. Indications Spleen-stomach stagnation of abdominal fullness or pain, indigestion. Chest tightness, abdominal distension, loss of appetite and loose stool in damp turbidity resistance. Cough and asthma caused by phlegm damp blocking the lung. It is used for fullness in the chest cavity, vomiting and diarrhea due to lack of food, and cough with excessive phlegm. "Compendium of Materia Medica": It's the best and always take the power of chess to regulate qi and dry dampness. If it is used with tonic, it will be tonic, if it is used with laxative, it will relieve, if it is used with ascending medicine, it will be raised, and if it is used with descending medicine, it will be lowered. The spleen is the mother of vital qi, and the lungs are the key to absorbing qi. Therefore, orange peel is the key to the division of qi in the two meridians, but it can be used to nourish, reduce, and ascend. "Daily Materia Medica": It can disperse and relieve diarrhea, warm and nourish, eliminate diaphragmatic qi, reduce phlegm and salivation, harmonize spleen and relieve cough, and relieve five stranguria.

Making Shouwu: The traditional Chinese medicine Polygonum Polygoni Multiflori can be divided into raw Shouwu and Zhishouwu. It is sliced directly and used as raw Shouwu. It is mixed with black bean juice and steamed, then dried and used as Zhishouwu. The functions of the two are different: raw Shouwu has the functions of detoxification, eliminating carbuncles, and laxatives. For beard and hair, strong bones and muscles, used for blood deficiency and chlorosis, dizziness and tinnitus, premature graying of beard and hair, soreness of waist and knees, numbness of limbs, metrorrhagia and vaginal discharge, chronic malaria and physical weakness. The Shouwu used in the present invention is a good product for invigorating and tonifying the kidney.

Specific embodiments of the invention

Specific embodiment 1: Flour, traditional Chinese medicine additives, vegetable oil, milk, water and eggs are mixed evenly in proportion, yeast powder is added to ferment, then pressed and molded, put into an oven to bake, cooled, packaged, and finished.

Specific embodiment 2: After choosing 1:1 buckwheat flour and wheat flour and mixing evenly, add Chinese medicine additive powder accounting for one-fifth of it, and stir the three evenly; add appropriate amount of yeast, milk, water, vegetable oil, eggs, and honey , Stir evenly, ferment for 1-2 hours, wait for the dough to wake up, start compression molding, put it in the oven to bake, cool, pack, and the finished product.

Preparation of traditional Chinese medicine additives:

Example 1: Take 1000g of Perilla, 1000g of perilla, 1000g of hawthorn, 1000g of schisandra, 1000g of rehmannia glutinosa, 1000g of Jiaogulan, 1000g of Patrinia, 1000g of Shouwu, 1000g of cassia seed, 1000g of salvia miltiorrhiza, 1000g of tangerine peel, 1000g of kudzu root, 1000g of sealwort, Yam 1000g, Alisma 1000g, Radix Paeoniae Rubra 1000g, Ophiopogon japonicus 1000g, Prunella vulgaris 1000g. Put all the raw materials into 5-10 times the amount of ethanol, soak for 1-2 hours, heat and extract twice, 1-2 hours each time, remove the supernatant, combine the extracts, filter through 100-120 mesh, and extract twice The extracts were combined and left still, the ethanol was recovered under reduced pressure, and concentrated to a concentration of 0.6g crude drug/mL. After suction filtration, the relative density of the filtrate was about 1.08 at 20°C; the pressure was reduced to 0.03-0.08MPa, and the temperature was kept at 60-80°C, concentrated to a relative density of 1.20, and the extract at a temperature of 60°C-70°C, as component 1.

Then put the extracted dregs into 10 times the amount of ethanol, soak for 1-2 hours, heat and extract twice, 1-2 hours each time, combine the extracts, let stand, remove the supernatant, and then put In the decompression concentration tank, ethanol was recovered under reduced pressure, concentrated to a concentration of 0.1 g crude drug/mL, and suction filtered until the relative density of the filtrate was 1.06 at 20°C, which became component 2.

Combine components 1 and 2 and place them in a double-effect vacuum concentrator, concentrate to a concentrated liquid with a relative density of 1.25 at 90°C, and refrigerate at a low temperature of 0-5°C for 24 hours; Filter with diatomaceous earth, put the filtrate into a double-effect vacuum concentrator, and concentrate to contain 0.2g of crude drug per 1ml; put the concentrated extract into an oven, sterilize it with ultraviolet rays, and bottle it as powder.

Example 2: Take Peilan 1100g, Perilla 1200g, Hawthorn 1100g, Schisandra 1200g, Rehmannia glutinosa 1200g, Jiaogulan 1100g, Patrinia 1200g, Shouwu 1200g, Cassia 1200g, Salvia miltiorrhiza 1200g, Tangerine peel 1100g, Pueraria 1200g, Polygonatum 1200g, Yam 1100g, Alisma 1200g, Radix Paeoniae Rubra 1200g, Ophiopogon japonicus 1100g, Prunella vulgaris 1200g. Soak in water that accounts for 10 times its mass, heat and extract the soaked raw material drug twice, each time for 1-2 hours, remove the supernatant, combine the extracts, filter through 100-120 mesh, and then pass through the cut-off molecular weight of 5000-10000 ultrafiltration column ultrafiltration, the ultrafiltrate is reduced pressure and concentrated to the extract with a relative density of 1.06 at 80°C, heated and concentrated to a paste, and left to stand for use as component 1. Then put the medicinal dregs extracted in the above steps into 10 times the amount of ethanol, soak for 1-2 hours, heat and extract twice, each time for 1-2 hours, combine the extracts, leave the supernatant after standing, and then put the In the pressure concentration tank, ethanol is recovered under reduced pressure, concentrated to a concentration of 0.1g crude drug/mL, and suction filtered until the relative density of the filtrate is an extract of 1.06 at 20°C, which becomes component 2. Put component 1 and component 2 into a double-effect vacuum concentrator, concentrate to an extract with a relative density of 1.25 at 90°C, and refrigerate at a low temperature of 0-5°C for 24 hours; Filter with diatomaceous earth, put the filtrate into a double-effect vacuum concentrator, and concentrate to contain 0.2g of crude drug per 1ml; the concentrated ointment is sterilized by ultraviolet rays, and then made into powder for bottling.

Example 3: Take Peilan 1300g, Perilla 1100g, Hawthorn 1200g, Schisandra 1200g, Rehmannia glutinosa 1200g, Gynostemma 1200g, Patrinia 1100g, Shouwu 1200g, Cassia 1200g, Salvia miltiorrhiza 1200g, Tangerine peel 1100g, Pueraria 1200g, Polygonatum 1300g, Yam 1200g, Alisma 1200g, Radix Paeoniae Rubra 1200g, Ophiopogon japonicus 1100g, Prunella vulgaris 1100g, the raw materials are mixed according to the stated weight and part ratio, chopped and passed through a 150-180 mesh fine sieve, and the fine powder after sieving is set aside, Coarse particles are put into an acid and alkali resistant dipping pot, and are soaked with ethanol above 70 degrees at room temperature for 10 to 15 days, and the soaked liquid and medicinal residues are squeezed and filtered, and the filtrate is taken after separation; the filtrate is heated and concentrated to Paste, put it into the oven for drying, grind into fine powder after cooling, add sieved fine powder to mix into powder, sterilize with ultraviolet light and bottle.

Animal acute toxicity test of Chinese medicine additive of the present invention

Pharmacological toxicity test

Experimental example 1: Acute toxicity test of the present invention

1. Test materials: Animals: Kunming mice, weighing 18-25g, half male and half male, bred by the biological laboratory of Shandong University. Medicine: the present invention (all raw materials are mixed and decocted twice, combined and filtered, and the medicine liquid is taken) contains 0.0365mg/ml. the

2. Method:

1. Calculation of LD50: adopt the modified Cole's method, mice are randomly divided into 5 groups, 10 in every group, half male and half male, the present invention is dissolved in distilled water, made into maximum concentration, and administered according to the maximum allowable capacity of mice. Dosing is followed by 18, 14.4, 11.5, 9.2, 7.4 (g.kg-1) according to the crude drug amount, and after the animal is fasted (can't help water) for 18 hours, it is divided into two administrations (interval half an hour) in one day, 0.5ml each time, observe the animal death. the

2. Determination of maximum tolerated dose (MTD value): take 20 mice, 10 males and 10 males. The present invention is added with distilled water and dissolved to make the highest concentration. According to the maximum tolerance of the animal, the injection feeding device can twitch as the criterion. After the animals fasted (without water) for 18 hours, they were administered twice a day (with an interval of half an hour), 0.5ml each time (each ml contained 0.36g of crude drug), and the total drug dose was 18g of crude drug/kg.d, equivalent to Clinical adult 50Kg body weight dosage is 300 times. Continuous observation for 7 days after administration. the

3. Test results:

In the calculation of LD50, when the mice were administered with the maximum allowable concentration and the maximum allowable capacity (18g/Kg.d), no mice died, that is, no LD50 was detected, and only the maximum tolerated dose could be obtained. During the 7-day observation period , the animals' appetite, activity, coat color, mental state, etc. were all normal, and the development was normal, and no death was seen. That is, the dosage equivalent to 300 times of the clinical dose was selected, and no adverse reaction occurred, indicating that the acute toxicity was extremely small, and the MTD was greater than 18g/Kg.d. the

Experimental example 2: Acute toxicity and long-term toxicity test results

Acute toxicity test: give the present invention by one-time gavage of mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dose 14g/kg (every g of powder is equivalent to 10g crude drug), observe continuously for 7 days, no For any toxic reaction, the LD 50 of the drug could not be measured because the concentration and dose could not be increased. Determination of maximum tolerated dose: With the highest concentration and maximum gavage capacity, mice were gavaged three times with an interval of 5 hours, and then observed continuously for 7 days, and no case died. The dosage of the medicinal powder is >42g/kg.day (each g of medicinal powder is equivalent to 10g of crude drug), which is equivalent to 420 times of the clinical daily dosage of an adult in terms of kilogram body weight.

Long-term toxicity test: in order to observe whether long-term medication produces toxic reactions, give rats the present invention to feed respectively, by 70 times and 35 times (being 7g/kg/ day and 3.5g/kg/ day) of adult's clinical daily dose, continuous After feeding for 8 weeks, there was no abnormality in the behavior, eating, and body weight of the rats. Compared with the control group, the blood routine, liver and kidney functions, and various important organs had no abnormal changes. Any toxic and side effects of the invention. Acute and chronic toxicity tests on animals prove that the invention has a large safety range and is a safe and reliable health care product.

Efficacy research of Chinese medicine additive of the present invention:

Efficacy research

Experiment of lowering fasting blood glucose: select hyperglycemia model animals and group them according to the blood glucose level after fasting for 3 to 5 hours, randomly select a model control group and 3 dosage groups (the difference between the groups is not more than 1.1mmol/L). The dose group was given different concentrations of test samples, and the model control group was given solvent. For 30 consecutive days, the fasting blood sugar level was measured (fasting was the same as before the experiment), and the blood sugar level and blood sugar reduction percentage of animals in each group were compared.

Glucose tolerance test: hyperglycemia model animals were fasted for 3-5 hours, the dose group was given different concentrations of test samples, the model control group was given the same volume of solvent, and 15-20 minutes later, glucose 2.0g/kg or medical starch 3 ~5g/kg, measure the blood glucose values at 0, 0.5, and 2 hours after glucose administration or 0, 1, and 2 hours after administration of medical starch, and observe the model control group and test sample group after administration of glucose or medical starch. Changes in the area under the blood glucose curve at time points.

Judgment of results: If one of the two indicators of fasting blood sugar and glucose tolerance is positive, and it has no effect on the fasting blood sugar of normal animals, it can be judged that the animal experiment result of the test sample's auxiliary hypoglycemic function is positive.

Pharmacodynamic experiment:

1 Materials and methods

1.1 Materials

1.1.1 Drugs Powder of the present invention (prepared by Preparation Method 2, prepared as a reagent containing crude drug 0.2g/1ml); metformin hydrochloride (Shanghai Huashi Pharmaceutical).

1.1.2 Animals 96 Kunming mice, half male and half male, weighing (22.5±2.5) g, were provided by the Animal Experiment Center of Shandong University.

1.1.3 Reagents and instruments Streptozotocin (STZ) (SERVER Company), purchased from Huamei Company. Electronic balance AB204-WO (Mettler-Tor Co., Ltd., Switzerland); Hitachi 7150 automatic biochemical analyzer (Japan).

1.2 Method

1.2.1 Modeling and grouping Diabetes: Animals were repurchased, and after 1 week of adaptive feeding, they were randomly divided into a normal non-diabetic group of 8 and an experimental group of 40. The experimental group fasted for 12 hours before modeling, and STZ55mg was used for modeling /kg One-time intraperitoneal injection, blood sugar and urine sugar were measured 24 hours after administration, and for 3 consecutive days, if the urine sugar was qualitatively above +++, and the blood sugar value exceeded 16.5mmol/L, and remained unchanged, it was determined to be diabetes.

The successful modeling mice were randomly divided into 5 groups, model control group, metformin group, high, medium and low concentration groups of the present invention.

Hyperlipidemia: The animals were repurchased, and after 1 week of adaptive feeding, they were randomly divided into a normal non-hyperlipidemic group of 8 and an experimental group of 40. The experimental group fasted for 12 hours before modeling, and was administered for 1 week after modeling. The above high-fat emulsion containing 1% cholesterol, 20% lard, 2% sodium cholate, and 1% propylthiopyrimidine, once a day for 7 consecutive days. The successful modeling mice were randomly divided into 5 groups, model control group, metformin group, high, medium and low concentration groups of the present invention.

1.2.2 Administration and determination method Normal control group and model control group (ig equal volume of normal saline); metformin hydrochloride group (ig, 0.20g/kg); oral liquid group of the present invention (every day ig decoction of the present invention 2.0 g/kg, 3.0g/kg, 4.0g/kg). Each group was intragastrically administered, once a day, for 30 consecutive days. Fast 12 hours before the last administration, and 2 hours after administration, the eyes were removed to collect blood, and blood glucose and blood lipids were measured with an automatic biochemical analyzer.

1.2.3 Statistical processing All data are represented by "-χ ± S", and the data are analyzed and processed by SPSS11.5 statistical software. If the variances are homogeneous in comparison among multiple groups, use one-way analysis of variance, and if the variances are not uniform, use rank sum test. Paired t-test was used to compare before and after within the group.

2 results

2.1 Hypoglycemic experiment It can be seen from Table 1 that the high, medium and low concentration groups of the present invention can significantly reduce the blood sugar of the hyperglycemia mouse model, and the difference is statistically significant compared with the model control group (P<0.05).

Table 1 The influence of traditional Chinese medicine additives of the present invention on blood sugar in mice (-χ±S)

Note: Compared with normal control group, △△P<0.01; compared with model control group, *P <0.05, **P <0.01; NS, normal saline.

2.3 Lipid-lowering experiment It can be seen from Table 2 that the high, medium and low concentrations of the present invention can significantly reduce the TC and TG content of the hyperlipidemia mouse model, and compared with the model control group, the difference is statistically significant (P<0.05, P< 0.01).

Table 2 The influence of traditional Chinese medicine additives of the present invention on blood lipids in mice (χ±S)

Note: Compared with normal control group, ΔΔP <0.01; compared with model control group, *P <0.05, **P <0.01; NS, normal saline.

3 Discussion

In recent years, with the continuous improvement of people's living standards, the incidence of diseases such as diabetes and coronary heart disease has increased day by day. In human blood, the lipids contained in plasma are called blood lipids, including cholesterol, cholesterol lipids, triglycerides, phospholipids, and unlipidated fatty acids. When cholesterol, triglycerides, etc. all exceed normal values, it is collectively referred to as hyperlipidemia. Hyperlipidemia is the main pathogenic factor of atherosclerosis. It often causes serious consequences due to violation of vital organs, such as coronary heart disease, diabetes, cerebrovascular accident, intractable hypertension and nephrotic syndrome, pancreatitis, stone disease, fatty liver, etc. The occurrence and development of arteriosclerosis are closely related to hyperlipidemia. Chinese herbal medicines have stable effects and few side effects. Research on Chinese herbal medicines with hypoglycemic and lipid-lowering effects can provide more methods for clinical treatment of diabetes and hyperlipidemia.

The traditional Chinese diet pays attention to balance, and puts forward that "the five grains should be nourished, and the loss of beans will be bad; the five animals should be beneficial, and the excess will be harmful; The dietary principle of "and counting". Described in modern language, it is necessary to maintain the biodiversity of food sources, mainly cereals; eat more vegetables, fruits and potatoes; eat enough beans and their products every day; fish, poultry, meat, eggs, etc. Animal foods such as milk and milk should be eaten in moderation.

Diabetes is equivalent to the category of quenching thirst in traditional Chinese medicine. Chinese yam is also known as Huaishan and Ganping. Slightly fragrant but not dry, it is an essential medicine for the lung and spleen. Pueraria lobata is sweet and pungent, can promote energy and clear yang, encourage stomach qi to ascend and produce body fluid to quench thirst. Ophiopogon japonicus is sweet, slightly bitter and cold, moistens the lungs and nourishes yin, clears the heart and relieves restlessness, and is effective for internal heat and quenching thirst caused by internal heat consumption. Huangjing Ganping can nourish yin and moisten the lungs, but also benefit qi. It is sweet and moist, enters the three meridians of the lung, spleen and kidney, and is good at nourishing yin. It is a good product for treating various syndromes of thirst. , It can be effective with a large amount of clothes alone. Salvia miltiorrhiza is bitter and slightly cold, specially enters the blood system, and its function lies in promoting blood circulation and promoting blood circulation, and is an important medicine for stagnation of blood stasis. It can break old blood and replenish new blood. The whole prescription nourishes yin and moisturizes dryness, regulates blood and lowers blood sugar, and achieves results through whole body regulation.

In fact, when some Chinese people are keen on westernizing their diet, the oriental dietary structure represented by the traditional Chinese dietary structure is attracting more and more attention from the world. It is generally believed that food is an edible substance that provides the human body with various nutrients needed for growth, development and healthy survival. In other words, the most important thing about food is nutrition. In fact, Chinese medicine has long recognized that food can not only provide nutrition, but also cure diseases. For example, Zhang Xichun, a modern physician, once pointed out in "Medical Hearts in Shenxilu": Food "can not only cure the disease, but also satisfy the hunger; not only satisfy the hunger, but also palatable. If it is used to the symptoms, the disease will gradually heal, that is, it is not symptomatic." , and there is no other trouble." With the development of society, people pay more and more attention to the way of keeping in good health. Many foods suitable for health preservation have also been promoted. The common ones are multigrain powder, multigrain porridge, medicated diet and so on.

At present, Western medicine has made great achievements in the research and treatment of diabetic hyperlipidemia, but the liver and kidney function, digestive tract symptoms, muscle damage and rebound effect after drug withdrawal caused by long-term drug use are still difficult problems in treatment. Drug therapy mainly uses drugs, which are strong in nature and have been called "poison" since ancient times. They are mainly designed for curing diseases. Therefore, drug therapy has a limited scope of application and is mainly aimed at patients. It is an important means of treating and preventing diseases. If medicines are used casually, laxatives for deficiency syndromes, tonics for excess syndromes, warm medicines for heat syndromes, and cold and cool medicines for cold syndromes, not only cannot cure the disease, but will aggravate or even worsen the original condition. Therefore, the medication must be very cautious. Food therapy is based on food, which can not only achieve the purpose of health care, physical fitness and disease prevention, but also give people sensory and spiritual enjoyment, so that people can unconsciously achieve the purpose of disease prevention and treatment while enjoying the delicious food. . This kind of natural therapy is quite different from taking bitter medicines. It is not as easy to take as medicine and is difficult to adhere to. It is easy to accept and can be used for a long time. It is especially suitable for the conditioning and treatment of chronic diseases. The active ingredients of traditional Chinese medicine are extracted, and then used in diet therapy to make it "patients take it, not only cure the disease, but also satisfy the hunger; not only satisfy the hunger, but also palatable, use it to the symptoms, and the disease will gradually heal. He suffers".

Specific embodiment: patient man, Qin, 62 years old, obesity, dull complexion, high blood pressure, diabetes for many years. Insulin injections for many years. Greedy, eating greasy food. Stroke once. The family members said that they couldn't control their mouths and their blood sugar remained high. Inspection results: Blood pressure: 160/100 Hg. Weight: 80 kg. Height: 170CM. Blood routine examination: lymphocytes 44.5. Urine routine examination: urine specific gravity 1.030. Protein + biochemical test: blood sugar 5.04 (fasting), total cholesterol 5.31 (fasting), triglyceride 4.72, high-density lipoprotein cholesterol 1.54, low-density lipoprotein cholesterol 3.24. Color ultrasound medical diagnosis report: diabetes, fatty liver. Insulin injections for many years. I am more resistant to the taste and smell of traditional Chinese medicine. Diet is recommended.

Buy biscuit of the present invention as daily snack, 30 days are a course of treatment. After using 2 courses of treatment, I began to feel that my blood sugar did not fluctuate, nor did I feel dizzy. I usually start to eat more vegetables and fruits, increase the amount of exercise, control my weight, etc., and gradually reduce the use of insulin. Of course, since food therapy and drug therapy have their own strengths, both are indispensable in the process of disease prevention and treatment. They should be used for different diseases or different stages of diseases by using their strengths. Drug therapy cooperates with each other, cooperates with each other, and brings out the best in each other.

Claims (10)

1. a biscuit for auxiliary hyperglycemic, is characterized in that, described biscuit comprises following raw material: flour, Chinese medicine additive, vegetable oil, milk, water and egg; Its preparation method is for mixing, shaping, baking, cooling, packaging, finished product.

2. the biscuit of auxiliary hyperglycemic according to claim 1, is characterized in that, the raw flour used in described biscuit is mixed by 1:1 for buckwheat flour and wheat flour; The ratio of described Chinese medicine additive and flour is 1:5.

3. the biscuit of auxiliary hyperglycemic according to claim 1, it is characterized in that, the bulk drug of the Chinese medicine additive used in described biscuit raw material comprises: eupatorium, purple perilla, hawthorn, the fruit of Chinese magnoliavine, radix rehmanniae recen, gynostemma pentaphylla, field pennycress, RADIX POLYGONI MULTIFLORI PREPARATA, cassia seed, the red sage root, dried orange peel, the root of kudzu vine, sealwort, Chinese yam, rhizoma alismatis, the radix paeoniae rubrathe, the tuber of dwarf lilyturf, selfheal.

4. the biscuit of auxiliary hyperglycemic according to claim 1, it is characterized in that, the parts by weight of the Chinese medicine additive used in described biscuit raw material are: eupatorium 10 ~ 20 parts, purple perilla 10 ~ 20 parts, hawthorn 10 ~ 20 parts, 10 ~ 20 parts, the fruit of Chinese magnoliavine, radix rehmanniae recen 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, field pennycress 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the red sage root 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the root of kudzu vine 10 ~ 20 parts, sealwort 10 ~ 20 parts, Chinese yam 10 ~ 20 parts, rhizoma alismatis 10 ~ 20 parts, the radix paeoniae rubrathe 10 ~ 20 parts, the tuber of dwarf lilyturf 10 ~ 20 parts, selfheal 10 ~ 20 parts.

5. the biscuit of auxiliary hyperglycemic according to claim 1, it is characterized in that, the parts by weight of the Chinese medicine additive used in described biscuit raw material are: eupatorium 10 ~ 15 parts, purple perilla 10 ~ 15 parts, hawthorn 10 ~ 15 parts, 10 ~ 15 parts, the fruit of Chinese magnoliavine, radix rehmanniae recen 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, field pennycress 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, cassia seed 10 ~ 15 parts, the red sage root 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the root of kudzu vine 10 ~ 15 parts, sealwort 10 ~ 15 parts, Chinese yam 10 ~ 15 parts, rhizoma alismatis 10 ~ 15 parts, the radix paeoniae rubrathe 10 ~ 15 parts, the tuber of dwarf lilyturf 10 ~ 15 parts, selfheal 10 ~ 15 parts.

6. according to any one of Claims 1 to 5 auxiliary hyperglycemic biscuit in the preparation method of Chinese medicine additive that uses, it is characterized in that, the preparation process of described Chinese medicine additive comprises:

A. all bulk drugs are put into the ethanol heating and refluxing extraction 2 times accounting for its quality 5-10 times amount, as component 1;

The dregs of a decoction of the bulk drug b. said extracted crossed again put into water heating and refluxing extraction 2 times, as component 2;

C. by above-mentioned two kinds of extract components 1 and component also 2-in-1, be condensed into medicinal extract, after disinfection, make powder.

7. the preparation method of Chinese medicine additive according to claim 6, is characterized in that, in described step a, all raw materials are put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 1.

8. the preparation method of Chinese medicine additive according to claim 6, is characterized in that, in described step b, the dregs of a decoction that above-mentioned steps is extracted are put into and accounts for its volume 10 times of water gagings, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extract, remove supernatant after leaving standstill, then put into reduced pressure concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06 concentrate, become component 2.

9. the preparation method of Chinese medicine additive according to claim 6, is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2g crude drug amount; Be condensed into medicinal extract shape, put into oven drying and become pulvis, then ultraviolet sterilization tinning.

10. the preparation method of the Chinese medicine additive used in the biscuit of an auxiliary hyperglycemic according to any one of Claims 1 to 5, it is characterized in that, the preparation process of described Chinese medicine additive can also be: mixed by described ratio of weight and number by described bulk drug, shredded 150 ~ 180 order dusting covers, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, 10 ~ 15 days are flooded together with more than 70 degree ethanol, the liquid flooded and the dregs of a decoction are carried out squeeze and filter, after separation, gets filtrate; Described filtrate heating is concentrated into pasty state, puts into drying in oven, after cooling, grind to form fine powder, add that the fine powder sieved is mixed into pulvis, bottle after ultraviolet sterilization.