CN102743639B - Health care composition for improving appetite of patients in chemotherapy - Google Patents
Health care composition for improving appetite of patients in chemotherapy Download PDFInfo
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- CN102743639B CN102743639B CN201210227299.5A CN201210227299A CN102743639B CN 102743639 B CN102743639 B CN 102743639B CN 201210227299 A CN201210227299 A CN 201210227299A CN 102743639 B CN102743639 B CN 102743639B
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Abstract
The invention relates to a health care composition for improving the appetite of patients in chemotherapy. The composition comprises the following raw materials: 40 to 70 g of milkvetch root, 15 to 40 g of dwarf lilyturf tuber, 10 to 15 g of tall gastrodia tuber, 10 to 25 g of bighead atractylodes rhizome, 5 to 10 g of Indian bread, 5 to 10 g of lucid ganoderma spore powder, 15 to 25 g of wolfberry, 15 to 25 g of radish seeds, 15 to 25 g of prepared pinellia tuber, 10 to 25 g of clove, 10 to 25 g of dried orange peel and 1000 to 3000 g of oat.
Description
Technical field
The present invention relates to field of food, be specifically related to a kind of health composition of the chemotherapy patients's of improvement appetite.
Background technology
Chemotherapy is one of method of western medical treatment cancer, and chemotherapy simultaneously also can be killed and wounded healthy cell, causes feeling sick, a series of side effects in various degree of degradation under vomiting, poor appetite, leucocyte, even interrupts chemotherapy.At present, have some application to improve the product of chemotherapy patients's appetite, but effect is unsatisfactory, therefore, the health composition that exploitation improves chemotherapy patients's appetite relatively has realistic meaning.
Summary of the invention
The object of the present invention is to provide a kind of health composition of the chemotherapy patients's of improvement appetite.
The invention reside in by following raw material and form: the Radix Astragali 40～70g, the tuber of dwarf lilyturf 15～40g, rhizoma Gastrodiae 10～15g, the bighead atractylodes rhizome 10～25g, Poria cocos 5～10g, lucidum spore powder 5～10g, the fruit of Chinese wolfberry 15～25g, radish seed 15～25g, rhizoma pinellinae praeparata 15～25g, cloves 10～25g, dried orange peel 10～25g, oat 1000～3000g.
Preparation method of the present invention:
The Radix Astragali 40～70g, the tuber of dwarf lilyturf 15～40g, rhizoma Gastrodiae 10～15g, the bighead atractylodes rhizome 10～25g, Poria cocos 5～10g, lucidum spore powder 5～10g, the fruit of Chinese wolfberry 15～25g, radish seed 15～25g, rhizoma pinellinae praeparata 15～25g, cloves 10～25g, dried orange peel 10～25g, mixes, add 500-1500 g water, be heated to the 2-4 hour that seethes with excitement, filter, get filtrate, be concentrated into 100-300g, add honey 10-30 g, oat 1000～3000g, mix, add water 100-300 g, at temperature 25o C-35
oc keeps 6-12 hour, obtains product of the present invention.
The specific embodiment
Embodiment 1
Radix Astragali 40g, the tuber of dwarf lilyturf 15g, rhizoma Gastrodiae 10g, bighead atractylodes rhizome 10g, Poria cocos 5g, lucidum spore powder 5g, fruit of Chinese wolfberry 15g, radish seed 15g, rhizoma pinellinae praeparata 15g, cloves 10g, dried orange peel 10g, mixes, add 500 g water, be heated to seethe with excitement 2 hours, filter, get filtrate, be concentrated into 100g, add honey 10 g, oat 1000g, mix, add water 100 g, in temperature 25
oc keeps 6 hours, obtains product of the present invention.
Embodiment 2
Radix Astragali 70g, the tuber of dwarf lilyturf 40g, rhizoma Gastrodiae 15g, bighead atractylodes rhizome 25g, Poria cocos 10g, lucidum spore powder 10g, fruit of Chinese wolfberry 25g, radish seed 25g, rhizoma pinellinae praeparata 25g, cloves 25g, dried orange peel 25g, mixes, add 1500 g water, be heated to seethe with excitement 4 hours, filter, get filtrate, be concentrated into 300g, add honey 30 g, oat 3000g, mix, add water 300 g, in temperature 35
oc keeps 12 hours, obtains product of the present invention.
Embodiment 3
Radix Astragali 50g, the tuber of dwarf lilyturf 30g, rhizoma Gastrodiae 12g, bighead atractylodes rhizome 20g, Poria cocos 8g, lucidum spore powder 8g, fruit of Chinese wolfberry 20g, radish seed 20g, rhizoma pinellinae praeparata 20g, cloves 15g, dried orange peel 15g, mixes, add 1000 g water, be heated to seethe with excitement 3 hours, filter, get filtrate, be concentrated into 200g, add honey 20 g, oat 2000g, mix, add water 200 g, in temperature 20
oc keeps 8 hours, obtains product of the present invention.
The impact experiment of embodiment 4 product of the present invention on macrophage phagocytosis of mice
Get 30 of body weight 18-22 gram mouse, male and female half and half, be divided at random blank group, 3 groups of embodiment and White Phoenix Bolus of Black-bone Chicken group, each group mouse is pressed the dosage gastric infusion of table 1, every day 1 time, successive administration 10 days, blank group gives same volume distilled water, after last administration 1 hour, press method described in document < herbal pharmacology experimental methodology >, mouse peritoneal is only injected 5% chicken red blood cell normal saline suspension 0.5ml/, within 3 hours, post-tensioning cervical vertebra is put to death mouse, back of the body position is fixing, intraperitoneal injection of saline 2ml/ only, rinse abdominal cavity, draw peritoneal fluid 0.5ml, drip sheet, 37 ℃ of incubations 30 minutes, Giemsa stain, oil sem observation, the situation of 100 macrophage phagocytic chicken red blood cells of counting, calculate phagocytic percentage, the results are shown in Table 1.
The affect X ± SD of table 1 medicine on macrophage phagocytosis of mice
| Group | Number of animals (only) | Dosage (g/kg) | Phagocytic percentage (%) |
| Blank group | 10 | - | 28.3±12.1 |
| 3 groups of embodiment | 10 | 3.0 | 65.7±17.3* |
| White Phoenix Bolus of Black-bone Chicken group | 10 | 1.5 | 41.2±19.1 * |
*: with blank group ratio, P < 0.05; *: with model control group ratio, p < 0.01
Experimental result shows, the be significantly improved effect of mouse macrophage phagocytic percentage of product of the present invention, has the phagocytic function that activates Turnover of Mouse Peritoneal Macrophages.
Embodiment 4 product of the present invention is on the impact on EC (EAC) mouse
Get 50 of body weight 18-22g mouse, male and female half and half, under aseptic condition, the conventional inoculation of mouse peritoneal Ehrlich ascites carcinoma knurl liquid 0.1ml/ is only.Latter the 2nd day of inoculation, is divided into model control group, 3 groups of embodiment and White Phoenix Bolus of Black-bone Chicken group at random by body weight, respectively organizes mouse by the dosage gastric infusion of table 2, every day 1 time, successive administration 10 days.Model control group gives same volume distilled water.The 11st day beginning observed and recorded respectively organized the life span of mouse, calculates increase in life span, and t check between organizing, and this test repeats 3 times, the results are shown in Table 2.
The affect X ± SD of table 2 medicine on EC (EAC) mouse
| Group | Number of animals (only) | Dosage (g/kg) | Life span (my god) | Body weight (g) |
| Model control group | 10 | - | 13.21±2.14 | 16.56±4.37 |
| 3 groups of embodiment | 10 | 6.0 | 18.27±3.21* | 23.35±3.89* |
| White Phoenix Bolus of Black-bone Chicken group | 10 | 3.0 | 15.19±4.18* | 22.78±4.23* |
With model control group ratio, * P < 0.05; , product of the present invention has the effect that extends the mouse survival time, increases the effect of Mouse Weight.
Embodiment 4 product of the present invention causes the impact experiment of pigeon nausea model on cis-platinum
Get 30 of body weight 200-300g pigeons, male and female dual-purpose, is divided into model control group at random,, 3 groups of embodiment and whole gastrodia tuber Capsules group, each group is pressed the dosage gastric infusion of table 3, every day 1 time, successive administration 7 days, model control group gavage gives same volume distilled water.After last administration 45 minutes, each treated animal was pressed 5mg/kg dosage intravenous injection cis-platinum, the incubation period that after observed and recorded injection cis-platinum, in 4 hours, pigeon vomiting occurs and vomiting number of times, and between organizing, t value is checked, and the results are shown in Table 3.
Table 3 medicine causes the impact (X ± SD) of pigeon nausea model on cis-platinum
| Animal grouping | Dosage (g/kgbw) | Dosage (g/kg | (only) | Vomit incubation period (minute) | Vomiting number of times (inferior) |
| Model control group | 10 | - | 10 | 42.3±17.1 | 178.9±31.8 |
| 3 groups of embodiment | 10 | 6.0 | 10 | 69.2±19.8 | 104.1±23.2 |
| Whole gastrodia tuber Capsules group | 10 | 3.0 | 10 | 57.1±17.3 | 143.2±24.5 |
*: with model control group ratio, P < 0.05; From table result, the present invention can reduce cis-platinum cause pigeon vomiting occur number of times, cis-platinum causes that pigeon vomits preclinical effect.
Claims (1)
1. for improving the preparation method of composition for chemotherapy patients's appetite, it is characterized in that:
The Radix Astragali 40～70g, the tuber of dwarf lilyturf 15～40g, rhizoma Gastrodiae 10～15g, the bighead atractylodes rhizome 10～25g, Poria cocos 5～10g, lucidum spore powder 5～10g, the fruit of Chinese wolfberry 15～25g, radish seed 15～25g, rhizoma pinellinae praeparata 15～25g, cloves 10～25g, dried orange peel 10～25g, mixes, and adds 500-1500 g water, be heated to the 2-4 hour that seethes with excitement, filter, get filtrate, be concentrated into 100-300g, add honey 10-30 g, oat 1000～3000g, mixes, and adds water 100-300 g, keep 6-12 hour 25 ℃-35 ℃ of temperature, obtain product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210227299.5A CN102743639B (en) | 2012-07-03 | 2012-07-03 | Health care composition for improving appetite of patients in chemotherapy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210227299.5A CN102743639B (en) | 2012-07-03 | 2012-07-03 | Health care composition for improving appetite of patients in chemotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102743639A CN102743639A (en) | 2012-10-24 |
| CN102743639B true CN102743639B (en) | 2014-06-25 |
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| CN201210227299.5A Expired - Fee Related CN102743639B (en) | 2012-07-03 | 2012-07-03 | Health care composition for improving appetite of patients in chemotherapy |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087826A (en) * | 1993-11-09 | 1994-06-15 | 王起福 | Longevity Testudinis tonic wine and manufacture method thereof |
| CN101279037B (en) * | 2007-04-03 | 2011-05-25 | 北京亚东生物制药有限公司 | Composition for curing impairment by overeating |
| CN102038857B (en) * | 2009-10-09 | 2012-06-13 | 北京亚东生物制药有限公司 | Method for preparing Chinese medicinal composition for treating child dyspepsia caused by overeating |
| CN101829307B (en) * | 2010-05-28 | 2013-05-08 | 辽宁省中医药研究院 | Medicament for treating digestive tract side effects caused by cancer chemotherapy |
| CN102326644A (en) * | 2011-06-02 | 2012-01-25 | 山东上水农业发展股份有限公司 | Children digestion-promoting tea |
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