CN101862355A - Medicine compound having function of promoting immunity - Google Patents
Medicine compound having function of promoting immunity Download PDFInfo
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- CN101862355A CN101862355A CN201010219386A CN201010219386A CN101862355A CN 101862355 A CN101862355 A CN 101862355A CN 201010219386 A CN201010219386 A CN 201010219386A CN 201010219386 A CN201010219386 A CN 201010219386A CN 101862355 A CN101862355 A CN 101862355A
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- spirulina
- pharmaceutical composition
- medicine
- food
- fermented cordyceps
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Abstract
The invention belongs to the technical field of medicine or food and discloses a medicine compound containing spiral seaweed and worm grass fermenting fungus powder. The medicine compound is characterized in that the weight part of the spiral seaweed is 0.1 to 2 and the weight part of the worm grass fermenting fungus powder is 0.05 to 1. The pharmacodynamic test shows that the medicine compound of the invention has the function of promoting immunity and can promote the curative effect on the basis of reducing spiral seaweed dosage.
Description
Technical field
The invention belongs to medical technical field, be specifically related to contain in a kind of raw material the pharmaceutical composition of fermented Cordyceps powder and spirulina.
Background technology
Spirulina is a class rudimentary plant, belongs to Cyanophyta, Oscillariaceae.They are the same with antibacterial, do not have real nucleus in the cell, so claim cyanobacteria again.The cellularity of cyanophyceae is original, and very simple, is the photosynthetic organism that occurs the earliest on the earth, has survived on this celestial body 3,500,000,000 years.It grows in the water body, is that spiral is thread in visible its form of microscopically, so gain the name.
Hundreds of years preceding more African clans just make spirulina algal biscuit and eat.In recent decades, scientist finds that spirulina is the human classic pure natural protein food source of being found up to now, and be that protein content is up to 60～70%, be equivalent to 6 times of Semen Tritici aestivi, 4 times of Carnis Sus domestica, 3 times of the flesh of fish, 5 times of egg, 2.7 times of cheese, and digestibility is up to more than 95%.Its distinctive phycocyanin can improve lymphocyte activity, strengthens body immunity, therefore gastrointestinal disease and hepatopath's rehabilitation is acquired a special sense.Wherein vitamin and content of mineral substances are very abundant, comprise vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin E, vitamin K etc., and contain trace element such as zinc, ferrum, potassium, calcium, magnesium, phosphorus, selenium, iodine, its biological zinc, ferrum ratio need consistent with Human Physiology substantially, the easiest being absorbed by the body, can improve child's apositia, appetite stimulator fast.Its carotenoid content is 15 times of Radix Dauci Sativae, and vitamin B12 content is 4 times of Hepar Sus domestica, and iron content is 23 times of Herba Spinaciae, is the abundantest food of iron content, and therefore, spirulina has positive effect to preventing and treating anemia.Contain a large amount of Y-linolenic acid, this is a kind of unsaturated fatty acid of needed by human, is nourishing the brain and improving intelligence, the desirable material of removing blood fat, blood pressure regulation, cholesterol reducing.Spirulina polysaccharide in the spirulina has Antiradiation injury and the side reaction effect that improvement is put, chemotherapy causes, is the dietetic therapy good merchantable brand to tumor patient therefore.Chlorophyll content is very abundant in the spirulina, is more than 10 times of common vegetable content, to promoting human consumption, in and septicemia plain and improve allergic constitution, eliminating internal organs inflammation etc. all has positive role.Fat content has only 5% in the spirulina, and does not contain cholesterol, can make human body avoid the Excessive Intake heat when replenishing necessary albumen.Prove through a large amount of scientific research and testing both at home and abroad, spirulina is at cholesterol reducing and blood fat, anticancer, fat-reducing, stomach is protected in nourishing the stomach, treatment anemia and trace element deficiency, hepatoprotective, promote immunity, all there is positive role aspects such as adjustment metabolism, are recommended as " optimal food of 21st century " by FAO (Food and Agriculture Organization of the United Nation) and world's food association of the United Nations.
Though a kind of good health food of spirulina, its consumption needs 2-4g at every turn, and each for consumers dose is a bit big, therefore, how to reduce the consumption of spirulina, and can increase curative effect, need carry out the research of deep science.
Summary of the invention
For these reasons, the inventor studies by test of many times, selects fermented Cordyceps powder from some kinds of medicinal raw materials, behind Spirulin composition, not only can improve drug effect, and reduce the consumption of spirulina, has played 1+1 greater than 2 effect
The present invention is achieved through the following technical solutions.
A kind of pharmaceutical composition with raising immunity, crude drug comprises spirulina and fermented Cordyceps powder.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Spirulina 0.1-2 weight portion wherein, fermented Cordyceps powder is the 0.05-1 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Spirulina 0.1-1 weight portion wherein, fermented Cordyceps powder is the 0.05-0.2 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Spirulina 0.5 weight portion wherein, fermented Cordyceps powder is 0.1 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
The wherein pharmaceutical preparation of crude drug preparation.
The food of crude drug preparation wherein.
Wherein pharmaceutical preparation is tablet, capsule, granule, oral liquid or pill.
Wherein food is tablet, capsule, granule, oral liquid or pill.
Pharmacodynamics test
Test 1 improves immunity test
Laboratory animal: BALB/C male mice, body weight 18-20g.
Trial drug:
Medicine 1: spirulina;
Medicine 2: pharmaceutical composition, spirulina 2.5g, fermented Cordyceps powder 0.05g.
Medicine 3: pharmaceutical composition of the present invention, spirulina 0.5g, fermented Cordyceps powder 0.1g.
Test method: get mice, random packet is a hypoimmunity in the mice modeling in advance, and not modeling of normal group, modeling successfully begin administration, and matched group gives normal saline 0.2ml/20g.1 group of gastric infusion of administration, dosage 0.5g/kg, 2 groups, 3 groups dosage 0.4g/kg of administration, successive administration 20 days, 24 hours broken end sacrificed by exsanguination mices after the drug withdrawal, under aseptic condition, take out spleen, make splenocyte suspension with RPMI-1640 (containing 10% calf serum), and mouse boosting cell is adjusted to 5x106 cell/m1, be added in 96 well culture plates, every hole 100ul, each spleen add double (promptly adds ConA, and does not add ConA).ConA20ul (concentration is 100ug/ml), RPMI-1640 80ul makes every hole to the 200ul volume, cultivates 72 hours in 5%CO237 ℃ of calorstat, stops cultivating preceding 24 hours, and every hole adds 3H one TdR3.7x109 (iucr).With cell harvestor (TITERTEK CELL HARVESTER 550) collecting cell on 49 type glass fiber filter paper, use distilled water, 5% 3 ammonia acetic acid, absolute ethanol washing successively, filter paper is put 60 ℃ of incubator oven dry, be added in the cup that contains the 5ml scintillation solution, participate in radioactivity (cpm) through liquid scintillation instrument (BECKMEN LS 9800) survey, calculate stimulation index (SI) then, that is: SI=adds ConA hole cpm/ and does not add ConA hole cpm.
The influence that table 1 different pharmaceutical transforms the hypoimmunity mouse spleen lymphocyte
| Group | Stimulation index |
| Normal group | ??0.726±0.346 ** |
| Group | Stimulation index |
| Matched group | ??0.103±0.123 |
| 1 group of medicine | ??1.534±0.239 ** |
| 2 groups of medicines | ??2.476±0.489 **△ |
| 3 groups of medicines | ??2.843±0.423 **△ |
Annotate: compare with matched group
*P＜0.01; Compare △ P＜0.05 for 1 group with medicine.
Test the test of 2 antitumor
Laboratory animal: the C57BL/6 mouse inbred lines, female, 18-22g.
Experiment material: S180 cell strain.
Trial drug:
Medicine 1: spirulina;
Medicine 2: pharmaceutical composition of the present invention, spirulina 2.0g, fermented Cordyceps powder 1.0g.
Medicine 3: pharmaceutical composition of the present invention, spirulina 0.1g, fermented Cordyceps powder 0.05g.
Experimental technique: the mice with tumor model prepares the S180 cell of the trophophase of taking the logarithm, and the furnishing cell concentration is 2 * 10
9The cell suspension of/L, the left fore oxter that is inoculated in the C57BL/6 mouse inbred lines under the aseptic condition is subcutaneous, 0.2ml/ only, after treating into tumor (tumor is greater than 1mm * 1mm), the beginning GP TH, and gastric infusion is 36 days continuously, every day 1 time, dosage 0.8g/kg, matched group give the equivalent normal saline, and experiment mice is put to death after 24 hours in the last administration.Peel off the tumor body, weighing tumor body is wet.
Experimental result: see Table 2.
The influence of table 2 pair tumor-bearing mice S180 sarcoma
| Group | Tumor body weight g |
| Blank group | ??1.92±0.43 |
| Medicine 1 | ??1.34±0.45 * |
| Medicine 2 | ??0.91±0.29 ** |
| Medicine 3 | ??0.93±0.27 ** |
Annotate: compare with matched group,
*P＜0.05,
*P＜0.01.
Clinical trial
Clinical diagnosis is the patient who is used for hypoimmunity, strive for that patient agrees, give spirulina (2g/ time) respectively, medication medication compositions (spirulina 0.5g of the present invention, fermented Cordyceps powder is 0.1g/ time) preparation pill, after the medication 60 days, spirulina group improvement rate is 73.9%, pharmaceutical composition improvement rate 92.5% of the present invention
Conclusion (of pressure testing): above-mentioned test shows, the present invention with spirulina and fermented Cordyceps powder combination after, when increasing curative effect, reduce the consumption of spirulina.
Embodiment
Embodiment 1
A kind of have a pharmaceutical composition that improves immunity, spirulina 0.1g wherein, and fermented Cordyceps powder is 0.05g, Cordyceps polysaccharide 0.02g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 2
A kind of have a pharmaceutical composition that improves immunity, spirulina 2g wherein, and fermented Cordyceps powder is 1g, ginseng polysaccharide, garlicin be 0.5g altogether.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 3
A kind of have a pharmaceutical composition that improves immunity, spirulina 1g wherein, and fermented Cordyceps powder is 0.2g, Lac regis apis 0.7g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 4
A kind of have a pharmaceutical composition that improves immunity, spirulina 0.1g wherein, and fermented Cordyceps powder is 0.05g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 5
A kind of have a pharmaceutical composition that improves immunity, spirulina 1g wherein, and fermented Cordyceps powder is 0.2g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 6
A kind of have a pharmaceutical composition that improves immunity, spirulina 0.5g wherein, and fermented Cordyceps powder is 0.1g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 7
A kind of have a pharmaceutical composition that improves immunity, spirulina 0.45g wherein, and fermented Cordyceps powder is 0.095g, Cordyceps polysaccharide.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Claims (8)
1. one kind has the pharmaceutical composition that improves immunity, it is characterized in that crude drug comprises spirulina and fermented Cordyceps powder.
2. a kind of pharmaceutical composition that improves immunity that has according to claim 1, spirulina 0.1-2 weight portion wherein, fermented Cordyceps powder is the 0.05-1 weight portion.
3. a kind of pharmaceutical composition that improves immunity that has according to claim 1, spirulina 0.1-1 weight portion wherein, fermented Cordyceps powder is the 0.05-0.2 weight portion.
4. a kind of pharmaceutical composition that improves immunity that has according to claim 1, spirulina 0.5 weight portion wherein, fermented Cordyceps powder is 0.1 weight portion.
5. according to each described a kind of pharmaceutical composition that improves immunity that has of claim 1-4, the wherein pharmaceutical preparation of crude drug preparation.
6. according to claim 1-4 each described a kind of pharmaceutical composition that improves immunity that has, wherein food of crude drug preparation.
7. according to the described a kind of pharmaceutical composition that improves immunity that has of claim 5, wherein pharmaceutical preparation is tablet, capsule, granule, oral liquid or pill.
8. according to the described a kind of pharmaceutical composition that improves immunity that has of claim 6, wherein food is tablet, capsule, granule, oral liquid or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010219386A CN101862355A (en) | 2010-07-07 | 2010-07-07 | Medicine compound having function of promoting immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010219386A CN101862355A (en) | 2010-07-07 | 2010-07-07 | Medicine compound having function of promoting immunity |
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| Publication Number | Publication Date |
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| CN101862355A true CN101862355A (en) | 2010-10-20 |
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| CN201010219386A Pending CN101862355A (en) | 2010-07-07 | 2010-07-07 | Medicine compound having function of promoting immunity |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106538A (en) * | 2011-01-19 | 2011-06-29 | 云南怒江州东方大峡谷生物城有限责任公司 | Healthcare product prepared from rhodiola root, spirulina and notoginseng |
| CN102631489A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102631506A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102631493A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Health care composition |
| CN102631393A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Health care composition |
| CN102972676A (en) * | 2012-12-21 | 2013-03-20 | 北京康比特体育科技股份有限公司 | Food composition for strengthening immunity and preparation method thereof |
| CN103637187A (en) * | 2013-11-21 | 2014-03-19 | 威海五谷怡健食品有限公司 | Human body immunity improvement antifatigue health food and preparation method thereof |
| CN109329900A (en) * | 2018-12-10 | 2019-02-15 | 丽江程海湖天然螺旋藻生产基地有限公司 | A kind of Cordyceps militaris spirulina powder preparation method and applications |
| CN110771889A (en) * | 2019-10-25 | 2020-02-11 | 台州市立医院 | Active composition for improving immunity and preparation method and application thereof |
-
2010
- 2010-07-07 CN CN201010219386A patent/CN101862355A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106538A (en) * | 2011-01-19 | 2011-06-29 | 云南怒江州东方大峡谷生物城有限责任公司 | Healthcare product prepared from rhodiola root, spirulina and notoginseng |
| CN102631489A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102631506A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102631493A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Health care composition |
| CN102631393A (en) * | 2012-04-24 | 2012-08-15 | 杨翠红 | Health care composition |
| CN102631506B (en) * | 2012-04-24 | 2013-08-28 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102631393B (en) * | 2012-04-24 | 2013-08-28 | 杨翠红 | Health care composition |
| CN102631489B (en) * | 2012-04-24 | 2014-03-12 | 杨翠红 | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue |
| CN102972676A (en) * | 2012-12-21 | 2013-03-20 | 北京康比特体育科技股份有限公司 | Food composition for strengthening immunity and preparation method thereof |
| CN103637187A (en) * | 2013-11-21 | 2014-03-19 | 威海五谷怡健食品有限公司 | Human body immunity improvement antifatigue health food and preparation method thereof |
| CN109329900A (en) * | 2018-12-10 | 2019-02-15 | 丽江程海湖天然螺旋藻生产基地有限公司 | A kind of Cordyceps militaris spirulina powder preparation method and applications |
| CN110771889A (en) * | 2019-10-25 | 2020-02-11 | 台州市立医院 | Active composition for improving immunity and preparation method and application thereof |
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Application publication date: 20101020 |
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| WD01 | Invention patent application deemed withdrawn after publication |