CN101869589A - Medicinal composition for improving immunity - Google Patents
Medicinal composition for improving immunity Download PDFInfo
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- CN101869589A CN101869589A CN201010219283A CN201010219283A CN101869589A CN 101869589 A CN101869589 A CN 101869589A CN 201010219283 A CN201010219283 A CN 201010219283A CN 201010219283 A CN201010219283 A CN 201010219283A CN 101869589 A CN101869589 A CN 101869589A
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- echinacea
- pharmaceutical composition
- fermented cordyceps
- cordyceps powder
- medicine
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Abstract
The invention belongs to the technical field of medicines or foods. The invention discloses a medicinal composition which contains echinacea purpurea and fermented cordyceps powder. The medicinal composition is characterized by comprising the following components in part by weight: 0.2 to 4 parts of the echinacea purpurea and 0.05 to 1 part of the fermented cordyceps powder. A medicine efficacy experiment shows that the medicinal composition of the invention has a good effect on improving immunity, and enhances a curative effect on the basis of reducing the using amount of the echinacea purpurea.
Description
Technical field
The invention belongs to medical technical field, be specifically related to contain in a kind of raw material the pharmaceutical composition of Echinacea and fermented Cordyceps powder.
Background technology
Echinacea (Echinacea Moenck) is a class feverfew that originates in America, also claims SONGGUOJU.This platymiscium has 8 kinds, is perennial herb, and head inflorescence holds in the palm to be taper shape, has tubular flower and ligulate flower, is generally rose-colored or purple.The person is mainly Echinacea (Echinacean purpurea also claims Echinacea purpurea Moench) and Echinacea angustifolia (E.angustifolia Echinacea Angustifolia) wherein to be developed as the medicine, white SONGGUOJU (E.pallia).Echinacea is widely used in the west, it is world-famous " immunity " plant, have outstanding infection and immunologic enhancement, before more than 1000 years, American Indian in America has found this medical herbs with magical effect at first, and they treat various infection with Echinacea, the biting of insecticide and poisonous snake, diseases such as eczema, typhoid fever, pulmonary tuberculosis are requisite medicines in the clan.Because its definite curative effect effect is widely used in medicine, supplementary and health food the America and Europe at present.Sell in the rank in U.S.'s medicinal plants, 1995,1996,1997,1999 rank the first every year.In Europe, with the Echinacea position that the product of raw material occupies year sales volume first for several years running.With medication strictness, careful celebrated Germany, Echinacea becomes consumption maximum, hospital administration that purposes is the widest at element, and the infection of mainly treating and preventing various pathogen to cause is particularly effective to upper respiratory tract infection.
Echinacea can strengthen cellular immune function, shows lymphocyte quantity is increased, and vigor strengthens.The fresh extract of SONGGUOJU that See etc. (1997) confirms in the K562 cell model can obviously improve people's NK (NKT) cell killing function.Sun etc. (1999) discover, the SONGGUOJU root extract can obviously improve NK cell and the mononuclear cell number of normal male rat.Currier (2001) finds that Echinacea extract not only significantly increases NK cell quantity in the normal mouse spleen, and can make trouble lymphocytoma mice spleen NK cell quantity increase by 2.5 times, and significant prolongation tumor-bearing mice survival period.0 ' Neill (2002) has studied the effect of supplementary feeding Echinacea extract to horse racing.Find that Echinacea extract significantly improves horse racing neutrophil's phagocytic activity, peripheral blood medium-sized lymphocyte quantity increases; Also can increase peripheral red blood cells quantity and volume simultaneously, and content of hemoglobin and packed cell volume.
Though Echinacea is not the Chinese medicine material of China, the historical and vast amount of clinical of international long use proves that its enhance immunity and infection aspect are definitely effective, is the treasure that the world has.We research and develop Echinacea and preparation thereof, are the useful of the traditional pools of traditional Chinese medicine of China replenished.
Summary of the invention
For these reasons, the inventor studies by test of many times, selects fermented Cordyceps powder from some kinds of medicinal raw materials, after the Echinacea compositions, not only can improve drug effect, and reduce the consumption of Echinacea, has played 1+1 greater than 2 effect
The present invention is achieved through the following technical solutions.
A kind of pharmaceutical composition with raising immunity, crude drug comprises Echinacea and fermented Cordyceps powder.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Echinacea 0.2-4 weight portion wherein, fermented Cordyceps powder is the 0.05-1 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Echinacea 0.1-1 weight portion wherein, fermented Cordyceps powder is the 0.05-0.2 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
Echinacea 2 weight portions wherein, fermented Cordyceps powder is 0.1 weight portion.Crude drug also comprises one or more in tea polyphenols, lentinan, ginseng polysaccharide, the Radix Astragali, lycopene, garlicin, Lac regis apis, ganoderan, the carotene etc.
The wherein pharmaceutical preparation of crude drug preparation.
The food of crude drug preparation wherein.
Wherein pharmaceutical preparation is tablet, capsule, granule, oral liquid or pill.
Wherein food is tablet, capsule, granule, oral liquid or pill.
Pharmacodynamics test
Test 1 improves immunity test
Laboratory animal: BALB/C male mice, body weight 18-20g.
Trial drug:
Medicine 1: Echinacea;
Medicine 2: pharmaceutical composition, Echinacea 4.5g, fermented Cordyceps powder 0.05g.
Medicine 3: pharmaceutical composition of the present invention, Echinacea 2g, fermented Cordyceps powder 0.1g.
Test method: get mice, random packet is a hypoimmunity in the mice modeling in advance, and not modeling of normal group, modeling successfully begin administration, and matched group gives normal saline 0.2ml/20g.1 group of gastric infusion dosage of administration 0.5g/kg, 2 groups, 3 groups dosages of administration are 0.35g/kg, successive administration 20 days, 24 hours broken end sacrificed by exsanguination mices are taken out spleen after the drug withdrawal under aseptic condition, make splenocyte suspension with RPMI-1640 (containing 10% calf serum), and mouse boosting cell adjusted to 5x106 cell/m1, be added in 96 well culture plates every hole 100ul, each spleen adds double (promptly adds ConA, and does not add ConA).ConA20ul (concentration is 100ug/ml), RPMI-1640 80ul makes every hole to the 200ul volume, cultivates 72 hours in 5%C0237 ℃ of calorstat, stops cultivating preceding 24 hours, and every hole adds 3H one TdR3.7x109 (iucr).With cell harvestor (TITERTEK CELL HARVESTER 550) collecting cell on 49 type glass fiber filter paper, use distilled water, 5% 3 ammonia acetic acid, absolute ethanol washing successively, filter paper is put 60 ℃ of incubator oven dry, be added in the cup that contains the 5ml scintillation solution, participate in radioactivity (cpm) through liquid scintillation instrument (BECKMEN LS 9800) survey, calculate stimulation index (SI) then, that is: SI=adds ConA hole cpm/ and does not add ConA hole cpm.
The influence that table 1 different pharmaceutical transforms the hypoimmunity mouse spleen lymphocyte
| Group | Stimulation index |
| Normal group | ??0.742±0.297 ** |
| Matched group | ??0.097±0.116 |
| 1 group of medicine | ??1.793±0.246 ** |
| Group | Stimulation index |
| 2 groups of medicines | ??2.872±0.756 **△ |
| 3 groups of medicines | ??2.924±0.843 **△ |
Annotate: compare with matched group
*P＜0.01; Compare △ P＜0.05 for 1 group with medicine.
Test the test of 2 antitumor
Laboratory animal: the C57BL/6 mouse inbred lines, female, 18-22g.
Experiment material: S180 cell strain.
Trial drug:
Medicine 1: Echinacea;
Medicine 2: pharmaceutical composition of the present invention, Echinacea 4.0g, fermented Cordyceps powder 1.0g.
Medicine 3: pharmaceutical composition of the present invention, Echinacea 3g, fermented Cordyceps powder 0.2g.
Experimental technique: the mice with tumor model prepares the S180 cell of the trophophase of taking the logarithm, and the furnishing cell concentration is 2 * 10
9The cell suspension of/L, the left fore oxter that is inoculated in the C57BL/6 mouse inbred lines under the aseptic condition is subcutaneous, 0.2ml/ only, after treating into tumor (tumor is greater than 1mm * 1mm), the beginning GP TH, and gastric infusion is 36 days continuously, every day 1 time, dosage 1g/kg, matched group give the equivalent normal saline, and experiment mice is put to death after 24 hours in the last administration.Peel off the tumor body, weighing tumor body is wet.
Experimental result: see Table 2.
The influence of table 2 pair tumor-bearing mice S180 sarcoma
| Group | Tumor body weight g |
| Blank group | ??1.79±0.55 |
| Medicine 1 | ??1.86±0.59 |
| Medicine 2 | ??1.27±0.23 * |
| Medicine 3 | ??1.24±0.21 * |
Annotate: compare with matched group,
*P＜0.05.
Clinical trial
Clinical diagnosis is the patient who is used for hypoimmunity, strive for that patient agrees, give Echinacea (2g/ time) respectively, medication medication compositions (Echinacea 1.5g of the present invention, fermented Cordyceps powder is 0.15g/ time) preparation pill, after the medication 60 days, Echinacea group improvement rate is 82.1%, pharmaceutical composition improvement rate 94.9% of the present invention
Conclusion (of pressure testing): above-mentioned test shows, the present invention with Echinacea and fermented Cordyceps powder combination after, when increasing curative effect, reduce the consumption of Echinacea.
Embodiment
Embodiment 1
A kind of have a pharmaceutical composition that improves immunity, Echinacea 0.2g wherein, and fermented Cordyceps powder is 0.05g, Cordyceps polysaccharide 0.04g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 2
A kind of have a pharmaceutical composition that improves immunity, Echinacea 4g wherein, and fermented Cordyceps powder is 1g, ginseng polysaccharide, garlicin be 0.7g altogether.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 3
A kind of have a pharmaceutical composition that improves immunity, Echinacea 1.5g wherein, and fermented Cordyceps powder is 0.15g, Lac regis apis 0.6g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 4
A kind of have a pharmaceutical composition that improves immunity, Echinacea 0.2g wherein, and fermented Cordyceps powder is 0.05g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 5
A kind of have a pharmaceutical composition that improves immunity, Echinacea 1g wherein, and fermented Cordyceps powder is 0.05g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 6
A kind of have a pharmaceutical composition that improves immunity, Echinacea 3g wherein, and fermented Cordyceps powder is 0.2g.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 7
A kind of have a pharmaceutical composition that improves immunity, Echinacea 2g wherein, and fermented Cordyceps powder is 0.1g, Cordyceps polysaccharide.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Embodiment 8
A kind of have a pharmaceutical composition that improves immunity, Echinacea 1.5g wherein, and fermented Cordyceps powder is 0.16g, Cordyceps polysaccharide.
According to prior art, add adjuvant, be prepared into food or medicine, its preparation is tablet, capsule, granule, oral liquid or pill.
Claims (8)
1. a pharmaceutical composition that improves immunity is characterized in that crude drug comprises Echinacea and fermented Cordyceps powder.
2. a kind of pharmaceutical composition that improves immunity according to claim 1, Echinacea 0.2-4 weight portion wherein, fermented Cordyceps powder is the 0.05-1 weight portion.
3. a kind of pharmaceutical composition that improves immunity according to claim 1, Echinacea 1-3 weight portion wherein, fermented Cordyceps powder is the 0.05-0.2 weight portion.
4. a kind of pharmaceutical composition that improves immunity according to claim 1, Echinacea 2 weight portions wherein, fermented Cordyceps powder is 0.1 weight portion.
5. according to each described a kind of pharmaceutical composition that improves immunity of claim 1-4, the wherein pharmaceutical preparation of crude drug preparation.
6. according to each described a kind of pharmaceutical composition that improves immunity of claim 1-4, the food of crude drug preparation wherein.
7. according to the described a kind of pharmaceutical composition that improves immunity of claim 5, wherein pharmaceutical preparation is tablet, capsule, granule, oral liquid or pill.
8. according to the described a kind of pharmaceutical composition that improves immunity of claim 6, wherein food is tablet, capsule, granule, oral liquid or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010219283A CN101869589A (en) | 2010-07-07 | 2010-07-07 | Medicinal composition for improving immunity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010219283A CN101869589A (en) | 2010-07-07 | 2010-07-07 | Medicinal composition for improving immunity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101869589A true CN101869589A (en) | 2010-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010219283A Pending CN101869589A (en) | 2010-07-07 | 2010-07-07 | Medicinal composition for improving immunity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104172165A (en) * | 2014-08-15 | 2014-12-03 | 安徽和华生物医药科技有限公司 | Squalene oil and coneflower soft capsule and preparation method thereof |
-
2010
- 2010-07-07 CN CN201010219283A patent/CN101869589A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104172165A (en) * | 2014-08-15 | 2014-12-03 | 安徽和华生物医药科技有限公司 | Squalene oil and coneflower soft capsule and preparation method thereof |
| CN104172165B (en) * | 2014-08-15 | 2016-03-16 | 安徽和华生物医药科技有限公司 | A kind of squalene oil Echinacea soft capsule and preparation method |
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Application publication date: 20101027 |