CN104288262A - Method for preparing altitude stress resistant medicament - Google Patents

Method for preparing altitude stress resistant medicament Download PDF

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Publication number
CN104288262A
CN104288262A CN201410531924.4A CN201410531924A CN104288262A CN 104288262 A CN104288262 A CN 104288262A CN 201410531924 A CN201410531924 A CN 201410531924A CN 104288262 A CN104288262 A CN 104288262A
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add
powder
parts
water
rehd
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刘巴宁
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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ZHONGSHAN BAIOU PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the technical field of Chinese medicinal materials, and in particular to a method for preparing an altitude stress resistant medicament. The method comprises the following steps: (1) preparing thick pastes of safflower, rhodiola and Tibet coriander; (2) preparing dry malus toringoides powder; and (3) mixing raw materials. A lozenge prepared by adopting the method can effectively relieve headache, anorexia, lassitude, weakness, dizziness and the like caused by altitude stress, and provides a new choice for clinically preventing and treating altitude stress symptoms and relieving various symptoms caused by altitude stress.

Description

A kind of preparation method of altitude sickness prevention medicine
Technical field
The present invention relates to Chinese crude drug technical field, specifically a kind of preparation method of altitude sickness prevention medicine.
Background technology
Altitude sickness and acute high altitude sickness (acute high altitude disease, AHAD), after people arrives certain height above sea level, health is that the draught head, the oxygen content that adapt to cause because of height above sea level are few, the change of air drying etc., and the natural physiological reaction produced, when height above sea level generally reaches about 2700 meters, just have altitude sickness.Main manifestations is, show as headache, nervous, tachypnea, loss of appetite, asthenia, weak, dizzy, Nausea and vomiting, abdominal distention, diarrhoea, pain uncomfortable in chest, insomnia, dim eyesight, drowsiness, dizzy, numb hand and foot, tic etc., sign is increased heart rate, exaggerated respiration, blood pressure mile abnormality, face or edema of the limbs, die Blausucht etc.
Tibet Radix Brassicae Rapae (Brassica rapa Linn.) has another name called turnip, circle root (Tibet common name), is called " mother girl ", is the distinctive food in high altitude localities, medicine, raises three and use plant in Tibetan language.Tibet Radix Brassicae Rapae rich in proteins, crude fibre, calcium, phosphorus, ferrum and vitamin etc. more than 20 plant the nutritional labeling of needed by human body, what is more important Tibet yuenkanin extract has resisting oxygen lack and can improve body blood coefficient of oxygen utilization with medicine, increase blood confession, Promote immunity, thus it is relevant to improve body anaerobic condition.
Radix Rhodiolae (Rhodiola crenulata) is the medicine food dual purpose plant that the Tibetan common people commonly use, and primary growth is in the severe cold of Tibet plateau more than height above sea level 4500m, anoxia, strong sunshine, pollution-free area.There is heart tonifying, diastole cardiovascular and cerebrovascular vessel, oxygenating effect, contribute to purifying blood, remove refuse in blood, improve immunity and anti-fatigue ability.Also can activate cells in vivo simultaneously, improve cerebral tissue causes anoxia tolerance to fatigue, the resistance of strengthening cardiac muscle to anoxia, regulates blood pressure, makes internal body reach balance.
Malus toringoides (Rehd.) Hughes is Angiospermae, Dicotyledoneae, Rosaceae, Maloideae, group of Malus and Sorbus M. kansuensesSchneid plant, the multiformity of its morphological characteristic, plantation characteristic, the respectively equal tool of situation and complexity thereof.There is the character such as resistance, half dwarfing, precocity fruiting, high yield and raising fruit quality.
But how Malus toringoides (Rehd.) Hughes, Caulis et folium clerodendri bungei Herba hylotelephii erythrosticti, Tibet Radix Brassicae Rapae are prepared into a kind of production method possessing the medicine of altitude sickness prevention by scientific compatibility and have not yet to see report in prior art.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of buccal tablet of altitude sickness prevention.Buccal tablet prepared by the method can alleviate headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, Be very effective.
For achieving the above object, the technical solution used in the present invention is: a kind of preparation method of buccal tablet of altitude sickness prevention, and step comprises:
1), according to parts by weight get 10-25 part Caulis et folium clerodendri bungei Radix Rhodiolae and 5-10 part Tibet Radix Brassicae Rapae, decoct with water, precipitation filters, and filtrate is condensed into cream, then adds ethanol, and mixing, staticly settles, get supernatant, reclaims ethanol, is condensed into thick paste, for subsequent use;
2), according to parts by weight get Malus toringoides (Rehd.) Hughes 10-20 part, add water after pulverizing, heating and refluxing extraction 3-5 hour, filter, filtering residue with 6-8 times of water in heating and refluxing extraction twice, each 1-2 hour, filter, filtrate is merged, for subsequent use after concentrated, refining, drying;
3), step 1 is got) thick paste prepared, add step 2) the Malus toringoides (Rehd.) Hughes powder prepared, add 2-5 part glucose powder, 4-5 part powder of Radix Puerariae, 0.5-1 part citric acid again, mixing, make granule, drying lets cool, spray adds 0.2-1 part Herba Blumeae Balsamiferae, 0.1-1 part orange oil, 0.1-1 part olive oil, 0.2-1 part Mentholum, 10-20 part mass concentration are 50-80% ethanol, then add 1-2 part orange powder, tabletted.
Further in, step 2) in, the water added is 10 times of weight of Malus toringoides (Rehd.) Hughes.
Advantageous Effects of the present invention is: the buccal tablet that inventive method of the present invention obtains effectively can alleviate headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, for clinical prevention treatment altitude sickness disease, the individual various symptom that alleviation altitude sickness causes provides a kind of new selection.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A preparation method for the buccal tablet of altitude sickness prevention, step comprises:
1), according to parts by weight get 10 parts of Caulis et folium clerodendri bungei Radix Rhodiolaes and 5 parts of Tibet Radix Brassicae Rapae, decoct with water, precipitation filters, and filtrate is condensed into cream, then adds ethanol, and mixing, staticly settles, get supernatant, reclaims ethanol, is condensed into thick paste, for subsequent use;
2), according to parts by weight get Malus toringoides (Rehd.) Hughes 10 parts, after pulverizing, add the water of 10 times of weight, heating and refluxing extraction 3 hours, filter, filtering residue with 6 times of water in heating and refluxing extraction twice, each 1 hour, filter, filtrate is merged, for subsequent use after concentrated, refining, drying;
3), step 1 is got) thick paste prepared, add step 2) the Malus toringoides (Rehd.) Hughes powder prepared, add 2 parts of glucose powders, 4 parts of powder of Radix Puerariae, 0.5 part of citric acid again, mixing, make granule, drying lets cool, spray adds 0.2 part of Herba Blumeae Balsamiferae, 0.1 part of orange oil, 0.1 part of olive oil, 0.2 part of Mentholum, 10 parts of mass concentrations are 50% ethanol, then add 1 part of orange powder, tabletted.
Embodiment 2
A preparation method for the buccal tablet of altitude sickness prevention, step comprises:
1), according to parts by weight get 20 parts of Caulis et folium clerodendri bungei Radix Rhodiolaes and 7 parts of Tibet Radix Brassicae Rapae, decoct with water, precipitation filters, and filtrate is condensed into cream, then adds ethanol, and mixing, staticly settles, get supernatant, reclaims ethanol, is condensed into thick paste, for subsequent use;
2), according to parts by weight get Malus toringoides (Rehd.) Hughes 15 parts, after pulverizing, add the water of 10 times of weight, heating and refluxing extraction 4 hours, filter, filtering residue with 7 times of water in heating and refluxing extraction twice, each 1.5 hours, filter, filtrate is merged, for subsequent use after concentrated, refining, drying;
3), step 1 is got) thick paste prepared, add step 2) the Malus toringoides (Rehd.) Hughes powder prepared, add 3 parts of glucose powders, 5 parts of powder of Radix Puerariae, 1 part of citric acid again, mixing, make granule, drying lets cool, spray adds 0.8 part of Herba Blumeae Balsamiferae, 0.5 part of orange oil, 0.6 part of olive oil, 0.7 part of Mentholum, 15 parts of mass concentrations are 60% ethanol, then add 1.5 parts of orange powder, tabletted.
Embodiment 3
A preparation method for the buccal tablet of altitude sickness prevention, step comprises:
1), according to parts by weight get 25 parts of Caulis et folium clerodendri bungei Radix Rhodiolaes and 10 parts of Tibet Radix Brassicae Rapae, decoct with water, precipitation filters, and filtrate is condensed into cream, then adds ethanol, and mixing, staticly settles, get supernatant, reclaims ethanol, is condensed into thick paste, for subsequent use;
2), according to parts by weight get Malus toringoides (Rehd.) Hughes 20 parts, after pulverizing, add the water of 10 times of weight, heating and refluxing extraction 5 hours, filter, filtering residue with 8 times of water in heating and refluxing extraction twice, each 2 hours, filter, filtrate is merged, for subsequent use after concentrated, refining, drying;
3), step 1 is got) thick paste prepared, add step 2) the Malus toringoides (Rehd.) Hughes powder prepared, add 5 parts of glucose powders, 5 parts of powder of Radix Puerariae, 1 part of citric acid again, mixing, make granule, drying lets cool, spray adds 1 part of Herba Blumeae Balsamiferae, 1 part of orange oil, 1 part of olive oil, 1 part of Mentholum, 20 parts of mass concentrations are 80% ethanol, then add 1-2 part orange powder, tabletted.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (2)

1. a preparation method for the buccal tablet of altitude sickness prevention, is characterized in that, step comprises:
1), according to parts by weight get 10-25 part Caulis et folium clerodendri bungei Radix Rhodiolae and 5-10 part Tibet Radix Brassicae Rapae, decoct with water, precipitation filters, and filtrate is condensed into cream, then adds ethanol, and mixing, staticly settles, get supernatant, reclaims ethanol, is condensed into thick paste, for subsequent use;
2), according to parts by weight get Malus toringoides (Rehd.) Hughes 10-20 part, add water after pulverizing, heating and refluxing extraction 3-5 hour, filter, filtering residue with 6-8 times of water in heating and refluxing extraction twice, each 1-2 hour, filter, filtrate is merged, for subsequent use after concentrated, refining, drying;
3), step 1 is got) thick paste prepared, add step 2) the Malus toringoides (Rehd.) Hughes powder prepared, add 2-5 part glucose powder, 4-5 part powder of Radix Puerariae, 0.5-1 part citric acid again, mixing, make granule, drying lets cool, spray adds 0.2-1 part Herba Blumeae Balsamiferae, 0.1-1 part orange oil, 0.1-1 part olive oil, 0.2-1 part Mentholum, 10-20 part mass concentration are 50-80% ethanol, then add 1-2 part orange powder, tabletted.
2. the preparation method of the buccal tablet of altitude sickness prevention according to claim 1, is characterized in that, step 2) in, the water added is 10 times of weight of Malus toringoides (Rehd.) Hughes.
CN201410531924.4A 2014-10-11 2014-10-11 Method for preparing altitude stress resistant medicament Pending CN104288262A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020062912A1 (en) 2018-09-25 2020-04-02 中国人民解放军总医院 Medical application of pyrimidine sulfonamides derivatives
WO2020062913A1 (en) 2018-09-25 2020-04-02 中国人民解放军总医院 Medical use of prostacyclin receptor agonist

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101411759A (en) * 2007-10-17 2009-04-22 炉霍县林业开发总公司 Capsule for preventing altitude stress as well as preparation method and application thereof
CN102178756A (en) * 2011-04-21 2011-09-14 西藏屋脊之宝食品有限公司 Oral liquid for treating high altitude disease (HAD) and preparation method thereof
CN102657730A (en) * 2012-06-05 2012-09-12 西藏天力商贸有限公司 Rhodiola rosea buccal preparations for resisting altitude reaction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101411759A (en) * 2007-10-17 2009-04-22 炉霍县林业开发总公司 Capsule for preventing altitude stress as well as preparation method and application thereof
CN102178756A (en) * 2011-04-21 2011-09-14 西藏屋脊之宝食品有限公司 Oral liquid for treating high altitude disease (HAD) and preparation method thereof
CN102657730A (en) * 2012-06-05 2012-09-12 西藏天力商贸有限公司 Rhodiola rosea buccal preparations for resisting altitude reaction

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020062912A1 (en) 2018-09-25 2020-04-02 中国人民解放军总医院 Medical application of pyrimidine sulfonamides derivatives
WO2020062913A1 (en) 2018-09-25 2020-04-02 中国人民解放军总医院 Medical use of prostacyclin receptor agonist

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