CN105920371A - Ganoderma lucidum compound preparation effective in lowering 'three highs' - Google Patents

Abstract

The invention belongs to the field of preparation of health products and particularly relates to a Ganoderma lucidum compound preparation effective in lowering 'three highs' and a preparation method thereof. This preparation is made from the main materials according to parts by weight: 10-20 parts of Ganoderma lucidum, 8-10 parts of Rhizoma Gastrodiae, 14-16 parts of Spica Prunellae, 14-15 parts of Radix Salviae Miltiorrhizae, 10-12 parts of Semen Cassiae, 8-10 parts of Inonotus obliquus, 24-26 parts of Radix Ginseng, 16-20 parts of Radix Hemerocallidis Plicatae, 20-25 parts of Rhizoma Dioscoreae, 10-12 parts of Rhizoma Anemarrhenae, 10-12 parts of pollen, 10-12 parts of Semen Cuscutae, 12-15 parts of Semen Glycines Nigrae, 3-6 parts of Hippocampus, 2-3 parts of Folium Toonae Sinensis, and 4-5 parts of Herba Menthae. The formulation of the invention is developed scientifically, the materials are synergic, and this preparation is effective in clearing heat and toxicity, clearing upper heat to remove phlegm, soothing liver qi-stagnation, tonifying spleen and liver, regulating qi and activating blood, lowering blood pressure, blood sugar and blood lipid, and preventing symptoms such as cardiovascular diseases.

Description

A kind of lucid ganoderma complex preparation with fall three high effects

Technical field

The invention belongs to the preparation field of health products, be specifically related to a kind of lucid ganoderma complex preparation with fall three high effects and preparation method thereof.

Background technology

" three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipidemia.They are that modern society is derived from " rich man's disease ", possible individualism, it is also possible to interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises.So, any one of these three illness occurs, the later stage is all easily formed " three high diseases ".

Along with growth in the living standard and the change of rhythm of life, it is referred to as " three high diseases " (i.e. hypertension, hyperglycaemia and the high fat of blood) of " rich man's disease ", such as " old times king thanks to swallow before hall; fly into common people house ", the common disease of particularly more than 50 years old the elderly's health, the whole world is died from the number of cardiovascular and cerebrovascular disease every year and is up to 15,000,000 people, occupies the various cause of the death the first.High fat of blood can cause blood vessel embolism；Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain；Hyperglycaemia can cause diabetes.The World Health Organization the most clearly proposes, and prevents the first line of defence of cardiovascular disease from reducing " three high " exactly and controlling " three high ".

All big with kidney,spleen,liver three internal organs of " three high " have relation, stagnant as basic reason with phlegm-turbidity and blood stasis.Liver master dredges stagnant, and The spleen has the function to transport and transform nutrients.If the dysfunction of the spleen in transport, liver dysfunction, skin kidney deficiency, it is easy for obtaining " three high ".

Summary of the invention

Present invention aims to the deficiencies in the prior art, it is provided that a kind of lucid ganoderma complex preparation having fall three high effects and preparation method thereof.Between science development, each raw material, there is synergistic function in the formula of the present invention, have on clearing heat and detoxicating, clear reduce phlegm, soothing liver-qi stagnation, tonifying spleen nourishing the liver, regulating qi and activating blood, hypotensive, hypoglycemic, reducing blood lipid, the symptom such as prevention cardiovascular diseases.

For realizing the purpose of the present invention, adopt the following technical scheme that

A kind of lucid ganoderma complex preparation with fall three high effects, counts by weight, and its primary raw material consists of: glossy ganoderma 10-20 part, rhizoma Gastrodiae 8-10 part, selfheal 14-16 part, red sage root 14-15 part, cassia seed 10-12 part, Inonotus obliquus 8-10 part, ginseng 24-26 part, chrysanthemum 16-20 part, Chinese yam 20-25 part, wind-weed 10-12 part, pollen 10-12 part, seed of Chinese dodder 10-12 part, black soya bean 12-15 part, hippocampus 3-6 parts, Chinese Toon Leaves 2-3 part, peppermint 4-5 part.

More excellent, the described lucid ganoderma complex preparation with fall three high effects, to count by weight, its primary raw material consists of: glossy ganoderma 15 parts, 10 parts of rhizoma Gastrodiae, selfheal 15 parts, the red sage root 15 parts, cassia seed 10 parts, Inonotus obliquus 9 parts, ginseng 25 parts, 18 parts of chrysanthemum, Chinese yam 23 parts, the wind-weed 11 parts, pollen 11 parts, the seed of Chinese dodder 11 parts, 14 parts of black soya bean, hippocampus 5 parts, Chinese Toon Leaves 3 parts, peppermint 5 parts.

A kind of method preparing the lucid ganoderma complex preparation as above with fall three high effects, comprises the following steps:

1) take glossy ganoderma, rhizoma Gastrodiae, selfheal, the red sage root, peppermint and cassia seed, mix, add the water of 8-10 times of weight, after 80-90 DEG C of boiling 30-40min, filter；In filter residue, add the water of 4-6 times of weight, after 70-80 DEG C of boiling 40-50min, filter；Merge the filtrate of twice filtration, obtain filtrate 1；

2) take Inonotus obliquus, ginseng, chrysanthemum, Chinese yam, the wind-weed, pollen, the seed of Chinese dodder, black soya bean, hippocampus and Chinese Toon Leaves, mix, add the water of 6-7 times of weight, after 80-90 DEG C of boiling 30-40min, filter；In filter residue, add the water of 4-5 times of weight, after 70-80 DEG C of boiling 40-50min, filter；Merge the filtrate of twice filtration, obtain filtrate 2；

3) merging filtrate 1 and filtrate 2, is concentrated into 1g crude drug/1ml at 70-80 DEG C；Filter and obtain filtrate, by filtrate in 121 DEG C, steam sterilizing 30min under 0.11MPa；

4) filling, sealing.

Effect of raw material selected by the present invention is:

1) Inonotus obliquus contains substantial amounts of anticancer, hypotensive, hypoglycemic, the string class polysaccharide body of resurrection immunization, can improve the vigor of immunocyte, prevent the absorption of the harmful substances such as carcinogen, and promote excretion in stomach and intestine；

2) main component of ginseng is panaxoside, possibly together with materials such as panaxan, Radix Ginseng protein, ginseng essential oil, amino acid, inorganic elements, peptide matters, multivitamin, organic acid, alkaloid, fats, flavonoids, enzyme, sterol, nucleosides, lignin；It can reduce blood sugar, improves blood fat, increasing high density lipoprotein cholesterol, has effect of antiatherosclerosis；

3) chrysanthemum contains nutrient necessary to the human bodies such as abundant pollen, sugar, protein, vitamin C, calcium, fat, carrotene, amino acid, and it can significantly reduce the content of serum cholesterol；Possibly together with abundant crude fibre in day lily, the excretion of stool can be promoted；

4) Chinese yam contains mucus protein, has the hypoglycemic effect of fall, can effectively stop blood fat in the precipitation of vascular wall, prevent cardiovascular diseases；

5) wind-weed contains saponin, the mangiferin of flavonoids, isomangiferin, the choline of alkaloids, niacinamide, the tannic acid of organic acid, nicotinic acid and four kinds of anemarans etc.；There is significant hypoglycemic activity；

6) pollen is rich in the composition such as several amino acids, vitamin A, vitamin C, vitamin E, active material and trace elements of selenium, phosphatide, nucleic acid；Have and prevent and treat the effect such as anaemia, diabetes；

7) seed of Chinese dodder has tonifying kidney and benefiting sperm, the effect nourished the liver to improve visual acuity；

8) hippocampus has the effect of warm kidney and enhancing body, regulating qi and activating blood；

9) Chinese Toon Leaves bitter, cold in nature, there is effect that clearing heat and detoxicating, stomach invigorating is regulated the flow of vital energy；

10) black soya bean is rich in the amino acid useful to human body, unrighted acid and the various trace elements such as calcium, phosphorus, is of value to diseases such as preventing and treating hypertension, high fat of blood, heart disease；

11) glossy ganoderma is owing to promoting the tissue utilization to sugar, may replace disengaging of insulin suppression aliphatic acid, can improve the symptom such as blood sugar, glucose in urine after taking glossy ganoderma；Water-soluble polysaccharide in glossy ganoderma, can alleviate the occurring degree of Non-Insulin Dependent Diabetes Mellitus；

12) rhizoma Gastrodiae contains gastrodin, gastrodia elata polysaccharide, has the effect clear liver and improved vision, reduce blood pressure；

13) selfheal have clear liver and improve vision, heat-clearing dissipating bind, hypotensive effect；

14) cassia seed has the functions such as clearing away the liver-fire, wines used as antirheumatic, tonifying kidney and improving eyesight；

15) red sage root has promoting blood circulation, the relieving restlessness that clears away heart-fire, effect of antiatherosclerosis；

16) peppermint have dispelling wind and heat from the body, soothing liver-qi stagnation, clear on reduce phlegm, effect of mild mood.

The present invention has the advantage that compared with the prior art

1) traditional Chinese medicine is thought, " the going out " in " discrepancy " refers to the excretion of stool, urine, sweat, and " entering " refers to feed, " go out " more even more important than " entering ", if drainage difficulty, metabolic product, toxin etc. will be caused to smoulder internal, the vital organs of the human body are caused damage by blocking blood vessel；The present invention adds Inonotus obliquus, chrysanthemum, peppermint, Chinese yam, Chinese Toon Leaves in formula, play altogether clearing heat and detoxicating, nourishing Yin and falling fire, decorporation is let out, the merit of toxin expelling；

2) there is synergistic function in the formula of the present invention between science development, each raw material, have on clearing heat and detoxicating, clear reduce phlegm, soothing liver-qi stagnation, tonifying spleen nourishing the liver, regulating qi and activating blood, hypotensive, hypoglycemic, reducing blood lipid, the symptom such as prevention cardiovascular diseases；Synthesis treatment, fundamentally nurses one's health the functions such as spleen, liver, kidney, while steadily conditioning three height, moreover it is possible to maintain and nurse one's health each function.While ensureing current effect, strengthen the body resistance to consolidate the constitution, make long-term effect more stable, make three high patients no longer endure the torment of slight illness to the fullest extent.

Detailed description of the invention

For the openest rather than restriction present invention, below in conjunction with example, the present invention is described in further detail.

Embodiment 1

A kind of lucid ganoderma complex preparation with fall three high effects, counts by weight, and its primary raw material consists of: glossy ganoderma 10 parts, 10 parts of rhizoma Gastrodiae, selfheal 14 parts, the red sage root 15 parts, cassia seed 10 parts, Inonotus obliquus 10 parts, ginseng 24 parts, 20 parts of chrysanthemum, Chinese yam 20 parts, the wind-weed 12 parts, pollen 10 parts, the seed of Chinese dodder 12 parts, 12 parts of black soya bean, hippocampus 6 parts, Chinese Toon Leaves 2 parts, peppermint 5 parts.

A kind of method preparing the lucid ganoderma complex preparation as above with fall three high effects, comprises the following steps:

1) take glossy ganoderma, rhizoma Gastrodiae, selfheal, the red sage root, peppermint and cassia seed, mix, add the water of 9 times of weight, after 85 DEG C of boiling 35min, filter；In filter residue, add the water of 5 times of weight, after 75 DEG C of boiling 45min, filter；Merge the filtrate of twice filtration, obtain filtrate 1；

2) take Inonotus obliquus, ginseng, chrysanthemum, Chinese yam, the wind-weed, pollen, the seed of Chinese dodder, black soya bean, hippocampus and Chinese Toon Leaves, mix, add the water of 6 times of weight, after 85 DEG C of boiling 35min, filter；In filter residue, add the water of 4 times of weight, after 75 DEG C of boiling 45min, filter；Merge the filtrate of twice filtration, obtain filtrate 2；

3) merging filtrate 1 and filtrate 2, is concentrated into 1g crude drug/1ml at 75 DEG C；Filter and obtain filtrate, by filtrate in 121 DEG C, steam sterilizing 30min under 0.11MPa；

4) filling, sealing.

Using the preparation that the present embodiment 1 prepares for clinical testing, observe patient 40 example of type II diabetes altogether, be divided into two groups, its clinical test results is as follows:

Tested crowd: meet type II diabetes diagnosis and traditional Chinese medical science deficiency of both qi and yin hold concurrently heat symptom-complex diagnose slight state of an illness experimenter；Do not avoid delaying the moderate state of an illness or severe state of an illness person treatment, in the case of this compound granule drug effect is indefinite, be not selected as tested crowd；

Therapeutic scheme:

Test group: the present invention, each 20 ml, three times a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Control group: Jiangtangning Capsules, each 6, three times a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Forbidding during test that other hypoglycemic medicines are taken in merging, every day provides identical breakfast, lunch and dinner diet, reduces the interference of other factors as far as possible；

Test group curative effect: fasting blood-glucose curative effect obvious effective rate 39.12%, postprandial blood sugar obvious effective rate 39.08%, tcm symptom obvious effective rate 35.63%；

Control group curative effect: fasting blood-glucose curative effect obvious effective rate 29.13%, postprandial blood sugar obvious effective rate 33.50%, tcm symptom obvious effective rate 32.61%；

Process of the test has no the toxic and side effect to the heart, Liver and kidney function and hematological system and bad reaction.

Embodiment 2

A kind of lucid ganoderma complex preparation with fall three high effects, counts by weight, and its primary raw material consists of: glossy ganoderma 15 parts, 10 parts of rhizoma Gastrodiae, selfheal 15 parts, the red sage root 15 parts, cassia seed 10 parts, Inonotus obliquus 9 parts, ginseng 25 parts, 18 parts of chrysanthemum, Chinese yam 23 parts, the wind-weed 11 parts, pollen 11 parts, the seed of Chinese dodder 11 parts, 14 parts of black soya bean, hippocampus 5 parts, Chinese Toon Leaves 3 parts, peppermint 5 parts.

A kind of method preparing the lucid ganoderma complex preparation as above with fall three high effects, comprises the following steps:

1) take glossy ganoderma, rhizoma Gastrodiae, selfheal, the red sage root, peppermint and cassia seed, mix, add the water of 8 times of weight, after 80 DEG C of boiling 30min, filter；In filter residue, add the water of 4 times of weight, after 70 DEG C of boiling 40min, filter；Merge the filtrate of twice filtration, obtain filtrate 1；

2) take Inonotus obliquus, ginseng, chrysanthemum, Chinese yam, the wind-weed, pollen, the seed of Chinese dodder, black soya bean, hippocampus and Chinese Toon Leaves, mix, add the water of 6 times of weight, after 80 DEG C of boiling 30min, filter；In filter residue, add the water of 4 times of weight, after 70 DEG C of boiling 40min, filter；Merge the filtrate of twice filtration, obtain filtrate 2；

3) merging filtrate 1 and filtrate 2, is concentrated into 1g crude drug/1ml at 70 DEG C；Filter and obtain filtrate, by filtrate in 121 DEG C, steam sterilizing 30min under 0.11MPa；

4) filling, sealing.

Using the preparation that the present embodiment 2 prepares for clinical testing, observe middle and old age hypertension patient 49 example altogether, its clinical test results is as follows:

Therapeutic scheme:

Test group (29 example): the present invention, each 20 ml, three times a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Control group (20 example): Nitrendipine Tablet, each 10mg, once a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Forbidding during test that other blood-pressure drugs are taken in merging, every day provides identical breakfast, lunch and dinner diet, reduces the interference of other factors as far as possible；

Test group curative effect: the patients' blood of 95% recovers to normal value, and it is difficult to bounce-back；

Control group curative effect: the patients' blood of 80% recovers to normal value, but a drug withdrawal, blood pressure i.e. rises, and cures the symptoms, not the disease；

Process of the test has no the toxic and side effect to the heart, Liver and kidney function and hematological system and bad reaction.

Embodiment 3

A kind of lucid ganoderma complex preparation with fall three high effects, counts by weight, and its primary raw material consists of: glossy ganoderma 20 parts, 8 parts of rhizoma Gastrodiae, selfheal 16 parts, the red sage root 14 parts, cassia seed 12 parts, Inonotus obliquus 8 parts, ginseng 26 parts, 16 parts of chrysanthemum, Chinese yam 25 parts, the wind-weed 10 parts, pollen 12 parts, the seed of Chinese dodder 10 parts, 15 parts of black soya bean, hippocampus 3 part, Chinese Toon Leaves 3 parts, peppermint 4 parts.

A kind of method preparing the lucid ganoderma complex preparation as above with fall three high effects, comprises the following steps:

1) take glossy ganoderma, rhizoma Gastrodiae, selfheal, the red sage root, peppermint and cassia seed, mix, add the water of 10 times of weight, after 80 DEG C of boiling 30min, filter；In filter residue, add the water of 5 times of weight, after 75 DEG C of boiling 45min, filter；Merge the filtrate of twice filtration, obtain filtrate 1；

2) take Inonotus obliquus, ginseng, chrysanthemum, Chinese yam, the wind-weed, pollen, the seed of Chinese dodder, black soya bean, hippocampus and Chinese Toon Leaves, mix, add the water of 6.5 times of weight, after 85 DEG C of boiling 35min, filter；In filter residue, add the water of 4.5 times of weight, after 75 DEG C of boiling 45min, filter；Merge the filtrate of twice filtration, obtain filtrate 2；

3) merging filtrate 1 and filtrate 2, is concentrated into 1g crude drug/1ml at 75 DEG C；Filter and obtain filtrate, by filtrate in 121 DEG C, steam sterilizing 30min under 0.11MPa；

4) filling, sealing.

Using the preparation that the present embodiment 3 prepares for clinical testing, observe middle and old age hypertension patient 49 example altogether, its clinical test results is as follows:

Therapeutic scheme:

Test group (29 example): the present invention, each 20 ml, three times a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Control group (20 example): Nitrendipine Tablet, each 10mg, once a day, half an hour ante cibum takes, the course for the treatment of surrounding；

Forbidding during test that other blood-pressure drugs are taken in merging, every day provides identical breakfast, lunch and dinner diet, reduces the interference of other factors as far as possible；

Test group curative effect: the patients' blood of 90% recovers to normal value, and it is difficult to bounce-back；

Control group curative effect: the patients' blood of 80% recovers to normal value, but a drug withdrawal, blood pressure i.e. rises, and cures the symptoms, not the disease；

Process of the test has no the toxic and side effect to the heart, Liver and kidney function and hematological system and bad reaction.

The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent and modification, all should belong to the covering scope of the present invention.

Claims (3)

1. a lucid ganoderma complex preparation with fall three high effects, it is characterised in that: counting by weight, its primary raw material consists of: glossy ganoderma 10-20 part, rhizoma Gastrodiae 8-10 part, selfheal 14-16 part, red sage root 14-15 part, cassia seed 10-12 part, Inonotus obliquus 8-10 part, ginseng 24-26 part, chrysanthemum 16-20 part, Chinese yam 20-25 part, wind-weed 10-12 part, pollen 10-12 part, seed of Chinese dodder 10-12 part, black soya bean 12-15 part, hippocampus 3-6 parts, Chinese Toon Leaves 2-3 part, peppermint 4-5 part.

The lucid ganoderma complex preparation with fall three high effects the most according to claim 1, it is characterised in that: counting by weight, its primary raw material consists of: glossy ganoderma 15 parts, 10 parts of rhizoma Gastrodiae, selfheal 15 parts, the red sage root 15 parts, cassia seed 10 parts, Inonotus obliquus 9 parts, ginseng 25 parts, 18 parts of chrysanthemum, Chinese yam 23 parts, the wind-weed 11 parts, pollen 11 parts, the seed of Chinese dodder 11 parts, 14 parts of black soya bean, hippocampus 5 parts, Chinese Toon Leaves 3 parts, peppermint 5 parts.

3. the method preparing the lucid ganoderma complex preparation as claimed in claim 1 or 2 with fall three high effects, it is characterised in that: comprise the following steps:

1) take glossy ganoderma, rhizoma Gastrodiae, selfheal, the red sage root, peppermint and cassia seed, mix, add the water of 8-10 times of weight, after 80-90 DEG C of boiling 30-40min, filter；In filter residue, add the water of 4-6 times of weight, after 70-80 DEG C of boiling 40-50min, filter；Merge the filtrate of twice filtration, obtain filtrate 1；

2) take Inonotus obliquus, ginseng, chrysanthemum, Chinese yam, the wind-weed, pollen, the seed of Chinese dodder, black soya bean, hippocampus and Chinese Toon Leaves, mix, add the water of 6-7 times of weight, after 80-90 DEG C of boiling 30-40min, filter；In filter residue, add the water of 4-5 times of weight, after 70-80 DEG C of boiling 40-50min, filter；Merge the filtrate of twice filtration, obtain filtrate 2；

3) merging filtrate 1 and filtrate 2, is concentrated into 1g crude drug/1ml at 70-80 DEG C；Filter and obtain filtrate, by filtrate in 121 DEG C, steam sterilizing 30min under 0.11MPa；

4) filling, sealing.