CN101485716A - Medicament for treating radiation injury and preparation method thereof - Google Patents
Medicament for treating radiation injury and preparation method thereof Download PDFInfo
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Abstract
The invention provides a drug for treating radiation injury and a method for preparing the same, and belongs to the field of traditional Chinese medicine preparation process. The traditional Chinese medicines are used as raw materials to prepare the drug through extraction of a formulation. The drug is characterized in that the drug consists of four medicinal materials in portion by weight: 5 to 15 portions of integripetal rhodiola herb, 15 to 25 portions of astragalus root, 5 to 15 portions of acanthopanax root extract and 80 to 100 portions of sea backthern. The preparation method comprises that: the astragalus root and the sea backthern are mixed, are decocted with water for two times, and are filtered; the filtrate is combined and is condensed to extract with relative density of between 1.28 and 1.30 (80 DEG C); and the extract, the acanthopanax root extract and pulverized integripetal rhodiola herb fine powder are mixed and evenly stirred, are dried at temperature of 60 DEG C, are pulverized, are filtered by a 80-mesh sieve, and are pelletized into particles; and the particles are dried at temperature of less than 80 DEG C, and are capsulated into a No. 0 capsule to obtain the drug. The clinical test and experimental research show that the drug has the function of treating the radiation injury, and has no obvious adverse reaction, abundant sources of the raw materials, and low production cost.
Description
Affiliated technical field
The invention belongs to medicine of a kind of radiotherapy damage and preparation method thereof, the medicine that specifically a kind of radiotherapy of mainly being made up of Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae 4 flavor medicinal material extract is damaged.
Background technology
Growing along with science and technology, electromagnetic radiation is more and more in our life, as various radio and television equipments, the portable computer product, the household electrical appliance radiation also has x-ray fluoroscopy, CT, nuclear magnetic resonance, NMR and the tumour patient of medically extensive use to need long-term radiotherapy, in addition, the radiation of construction material is also more and more, and along with the construction of nuclear power station speeds up, potential radioprotective also can not be ignored or the like.
Various putting (spoke) penetrated system's stress such as blurred vision such as can causing nerve, cardiovascular, breathing, and the whole body such as mentally deranged, uncomfortable in chest, rapid breathing, headache, cough are violent uncomfortable; Can cause a series of acute injuries such as tissue organ function, structure, metabolism, zymetology and free radical and biomacromolecule etc. such as human bone marrow's hemopoietic, immunity and reproduction subsequently.
Therefore, research control radiation injury medicine has important practical value and realistic meaning for us, but China is applied to prevent and treat the medicine of radiation injury at present clinically, mostly be chemical synthetic drug, its toxic and side effects is big, and do not have independent intellectual property right, so the natural drug of exploitation radiotherapy damage is very necessary.
Summary of the invention
It is definite to the purpose of this invention is to provide a kind of clinical efficacy, and toxic and side effects is little, the medicine of the cheap and radiotherapy that has wide range of applications damage.
The embodiment of the object of the invention is: the optimization ratio of being made up of Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae four Chinese medicine material is (according to its weight ratio): 10 parts of Radix Rhodiolaes, 20 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 90 parts of Fructus Hippophaes; It is characterized in that adopting following preparation technology to make capsule: the Radix Astragali and Fructus Hippophae are mixed decocting twice, filter, merging filtrate is concentrated into the extractum of relative density 1.28-1.30 (80 ℃); The Radix Rhodiolae fine powder of gained extractum and Radix Et Caulis Acanthopanacis Senticosi extractum and pulverizing mixes to be mixed thoroughly, and powder is beaten in 60 ℃ of oven dry down, crosses 80 mesh sieves, granulates, and oven dry is packed No. 0 capsule into promptly below 80 ℃.Treat the radiation damage of light moderate clinically, its usage is every day three times, and each 3, serveing on for 4 weeks is a course of treatment.
Radix Rhodiolae is a monarch drug in the side, is the peculiar rare medicinal herbs in Qinghai-Tibet.Cure mainly cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change silt detumescence, analgesicly bring down a fever, nourish effect external such as vigour and control traumatic injury and burn and scald.Mainly contain effective constituent rhodioloside (Salidroside) C is arranged
14H
20O
7Butyl alcohol (Tyrosol) C
6H
10O
2Contain starch, protein, fat, tannin, flavone compound, phenolic compound and micro-volatile oil in addition, also contain trace elements iron, aluminum, zinc, silver, cobalt, cadmium, titanium, molybdenum, manganese of biologically active etc., contain a small amount of biological alkali in leaf and the stem.Tibetan medicine's monumental work before more than 1,200 year,＜＜four doctor's allusion quotations〉in, the record of " refreshing medicine-sulu agate treasured " is just arranged.Ming Dynasty's Li Shizhen (1518-1593 A.D.)＜＜herbal guiding principle wood in be called " book on Chinese herbal medicine top grade ", Emperor Kangxi is bestowed the name called and is " Radix Rhodiolae "; Radix Rhodiolae contains abundant rhodioside, flavone, and multivitamin and trace element, according to the pharmacology, pathology and clinical observation on the therapeutic effect, Radix Rhodiolae is to be proved to be a kind of to the heart, and cerebrovascular disease has the natural herbal of significant curative effect.It can remove lipid too much in the blood, prevents the formation of tremulous pulse medicated porridge shape speckle, reduces blood viscosity, quickens red cell velocity, microcirculation improvement, and Peripheral resistance is reduced, thus reduce arterial pressure.Radix Rhodiolae can be expanded coronary artery effectively, resists myocardial ischemia, and improves cardiac function, also can improve the blood circulation of cerebral tissue, accelerates the recovery of cerebral infarction focus, and to alleviating headache, relieving fatigue, memory reinforcing etc. also have remarkable efficacy.Take Radix Rhodiolae for a long time and can prevent or slow down apoplexy and cardiopathic generation.Radix Rhodiolae treatment and prevention coronary heart disease, hypertension, cerebrovascular, climacteric syndrome, diseases such as neurasthenia and the angina pectoris that is caused thereof, uncomfortable in chest, cardiopalmus is breathed hard, insomnia, spiritlessness and weakness, the good medicine of altitude sickness etc. also has tangible auxiliary curative effect to multiple cancer.Expand coronary artery effectively, resist myocardial ischemia, improve cardiac function, also can improve the blood circulation of cerebral tissue, accelerate the recovery of cerebral infarction focus, to alleviating headache, relieving fatigue, memory reinforcing etc. also have remarkable efficacy.The Radix Astragali is sweet, and temperature is returned lung, spleen channel, cures mainly invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, it is weak to be used for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes etc., the successive dynasties, the well-known doctor had high praise to the Radix Astragali more, and modern pharmacology confirms that also the multiple composition of the Radix Astragali can prevent and treat radiation damage; Radix Et Caulis Acanthopanacis Senticosi extractum is the extract of Radix Et Caulis Acanthopanacis Senticosi, and Radix Et Caulis Acanthopanacis Senticosi also is Radix Acanthopanacis Senticosi, and acrid in the mouth, little hardship, slightly warm in nature are returned spleen, kidney, heart channel, but wind-damp dispelling, bone and muscle strengthening, the system of steeping in wine slender acanthopanax bark spirit (or make Cortex Acanthopancis and loose).Root bark contains volatile oil, tannin, brown eleostearic acid, linoleic acid, vitamin A, B1.Radix Et Caulis Acanthopanacis Senticosi sees Shennong's Herbal, classifies as top grade.Top grade is refer to nontoxic, for a long time clothes can make light of one's life by commiting suicide, life lengthening and harmless.Radix Et Caulis Acanthopanacis Senticosi promptly is regarded as having the good medicine that adds smart benefit marrow and anti-aging effects from ancient times.Former main product is in the mountain area, Heilongjiang Province, and local popular name is practised and claimed " tiger is hasty and careless ", then is called the smooth slender acanthopanax of shrimp in Japan, and is called Siberian ginseng in the former Soviet Union.Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica claims Radix Et Caulis Acanthopanacis Senticosi, and is good with the five leaf persons of accompanying each other, so the name slender acanthopanax has another name called five flowers.The slender acanthopanax dispelling the wind and dampness pathogens, strengthening bone and muscle, its merit is very dark, separates to obtain seven kinds of glycoside bodies (the sweet Elentheroside of Radix Et Caulis Acanthopanacis Senticosi) seven kinds of A, B, C, D, E, F, G from the Radix Et Caulis Acanthopanacis Senticosi rhizome.Eleutheroside contains 0.6-0.9% in root, contains 0.6-1.5% in stem, contains polysaccharide and isoflavone in addition.Eleutheroside A is a carotene, also contains this constituents in the Radix Ginseng.In human body, can promote the drainage of cholesterol, can prevent and treat the too high disease of cholesterol level in the blood.Radix Et Caulis Acanthopanacis Senticosi glucoside B is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, and short gonad, radioprotective, fatigue-resisting function are arranged, and has the physiologically active similar to the ginsenoside.Modern medicine studies have shown that the effect characteristics and the Radix Ginseng of Radix Et Caulis Acanthopanacis Senticosi is basic identical, has the disorder of the body of adjusting, makes it to be tending towards normal function.Good antifatigue effect is arranged, remarkable than Radix Ginseng, and can significantly improve hypoxia-bearing capability.Functions such as invigorating middle warmer, smart, the strong will of benefit, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, the diuresis of being good for the stomach.Fructus Hippophae is the Mongols, Tibetan's conventional crude drugs, this product acid, puckery, and temperature, but eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis is used for cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, the blood stasis amenorrhea falls and pounces on congestive edema etc., and is all on the books in the famous medical science ancient books and records of the Tang Dynasty and the Qing Dynasty." month king's medicine treasure ": " Fructus Hippophae is cured Baconic, enhancing body sun, appetizing relieving disorders of the chest, tasty and refreshing, the easy digestion of diet ", " four doctor's secret formula portions ": " the sharp lung cough-relieving of Fructus Hippophae, promoting blood circulation to remove blood stasis, removing phlegm-damp." " brilliant pearl book on Chinese herbal medicine ": " and the fruit of medium Fructus Hippophae is just as grain, hard drying, a pair of yellow kernel contains trace oil, the tonification blood of human body ".This " blue coloured glaze " medicinal flavor of Four-Volume Medical Code note is said: " Fructus Hippophae flavor warm in nature is little sweet, strongly invigorating primordial QI, and appetite stimulator, the circulation QI and blood, health invigorating is eliminated ' dragon ' disease, ' Baconic ' sick, ' red crust ' disease ".Modern study shows that its main component is the low glucoside (oligosides) of isorhamnetin (isorhamnetin), isorhamnetin-3-B-D-glycoside (isorhamnetin-3-B-D-glucoside), isorhamnetin-3-B-rutinoside (isorhamnetin-3-B-rutinoside), Mongolian oak chitin and kaempferol etc.Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae are ministerial drug in the side, assist a ruler in governing a country Radix Rhodiolae activating blood circulation to dissipate blood stasis detumescence, analgesicly bring down a fever, nourish effect such as vigour.
Specific embodiments
The embodiment of the object of the invention is: the optimization ratio of being made up of Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae 4 flavor medical materials is (according to its weight ratio): 10 parts of Radix Rhodiolaes, 20 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 90 parts of Fructus Hippophaes.
It is characterized in that adopting following preparation technology to make capsule:
1) Radix Astragali and Fructus Hippophae are mixed decocting twice, filter, merging filtrate is concentrated into the extractum of relative density 1.28-1.30 (80 ℃);
2) above gained extractum and Radix Et Caulis Acanthopanacis Senticosi extractum are beaten powder and are mixed and to mix thoroughly;
3) Radix Rhodiolae is beaten fine powder and is crossed 100 mesh sieves;
4) above four Chinese medicine material (extract) mixing is mixed thoroughly, powder is beaten in 60 ℃ of oven dry down, crosses 80 mesh sieves, granulates, and dries the capsule of packing into No. 0 below 80 ℃.
Experiment and the clinical effect that anti-low dose radiation damage of the present invention is described for example below
Example 1: zoopery
1 material and method
1.1 50 of the healthy SPF level of laboratory animal Kunming mouses are male, body weight 18～22g, and in 6～8 ages in week, male and female half and half are provided by this school Experimental Animal Center.
1.2 illuminate condition is used
60The disposable whole body uniform irradiation of Co-gamma-rays, close rate 3.2s/cGy, irradiation field 25cm * 25cm, SSD 80cm, exposure dose 6Gy, this school
60Carry out at Co irradiation center.
1.3 the method mice is divided into 5 groups at random, 10 every group.Experimental group: give
60The disposable total irradiation of Co gamma-rays 6Gy, irradiation back the 2nd day gives 1.0g/kg/d (high dose group), 0.5g/kg/d (middle dosage group) and 0.25g/kg/d (low dose group) respectively and irritates stomach, continuously 15d.Other establish negative control group (normal saline) and irradiation control group (
60Co gamma-rays 6Gy irradiation+normal saline).
1.4 observation index
1.4.1 analysis on hemogram is got the about 250 μ l of mouse tail blood and is added ED-TA-K220 μ L anticoagulant in shining the same day, send school pharmacology teaching and research room automatic analyzer to detect.Respectively at shining the back the 8th, 15 day, respectively get blood again 1 time, measure leukocyte, erythrocyte, platelet value.
1.4.2 mice is put to death in bone marrow nucleated cell counting irradiation dislocation in back 15 days, puts superclean bench, dissects mice, get its left side femur, with No. 7 needle pierces femur ends, reuse 10mLRPMI1640 culture fluid flushing bone marrow, at least wash 10 times, dash to till the white until femur, it is stand-by that the bone marrow fluid of going out is passed through No. 4 syringe needle filtrations, gets the medullary cell solution of 10 μ L mixings, add glacial acetic acid, fully mix, splash into counting chamber then, at microscopically counting nucleated cell.Nucleated cell number (L)=4 big grid nucleated cell sum/4 * 10
4* extension rate.
1.4.3 the bone marrow dna content is measured and got its right side femur, removes muscle, and is clean with normal saline flushing, cuts off the two ends epiphysis, with No. 7 needle pierces femur ends, with the CaCl of 5mmol/L
210ml washes bone marrow, and whole bone marrow are poured in the centrifuge tube, washes at least 10 times, till femur dashes to white.4 ℃ of refrigerators are placed 30min, and the centrifugal 15min of 2500rpm abandons supernatant then.The HClO that adds 0.2mol/L
45ml is with the abundant mixing of precipitate, and 90 ℃ of heating 15min cool off, and use filter paper filtering, and filtrate is measured the absorbance A value with ultraviolet spectrophotometer at the 268nm place.Calculate the every contained DNA of femur (μ g): DNA (μ g)=40 * 50 * A by following formula.
1.4.4 mice is put to death in the 15d dislocation of spleen tuberosity counting (CFU-S) irradiation back, get its spleen, after weighing, spleen is put into fixedly 24h of Bouin ' s liquid (with picric acid saturated aqueous solution, 37%～40%, 15: 5: 1), the taking-up afterflush is clean, the white point on naked eyes counting spleen surface, i.e. spleen tuberosity number.
1.4.5 the statistical procedures statistical analysis adopts SPSS10.0 software to handle, the gained data all use mean ± standard deviation (x ± s) expression, statistical method is used one factor analysis of variance (one-wayANOVA), with a=0.05 as touchstone.
2 results
2.1 the present invention to irradiation after the influence of mice hemogram
The mice that influences to murine interleukin is accepted
60After the Co-gamma-rays 6Gy irradiation, leukocyte count obviously reduces (P＜0.01), gives the present invention after the irradiation, compares with model group, can promote leukocytic recovery, and significant significant difference (P＜0.01 is arranged; See Table 1).
To the influence of mouse red blood cell as can be seen from Table 2, respectively organize the mouse red blood cell number after the irradiation and obviously reduce, no matter according to back the 8th, 15 day, each irradiation group RBC number was compared with negative control group, and difference all has the statistics meaning
Table 1 the present invention is to the leukocytic influence (* 10 of radiation murine
9/ L; N=10)
aP＜0.05,
bCompare with model group P＜0.01.
Justice (P＜0.05); Can slow down erythrocytic decline after the present invention's treatment, large, medium and small dosage group all has the erythrocytic effect of better protect, and 3 administration group RBC number are compared with irradiation control group, and difference all has statistical significance (P＜0.05 or P＜0.01; See Table 2).
Table 2 the present invention is to the erythrocytic influence (* 10 of radiation murine
12/ L; N=10)
aP＜0.05,
bCompare with model group P＜0.01.
The experimental result that influences to mouse platelets shows: respectively organize the mouse platelets number after the irradiation and obviously reduce, descending more obvious according to back 15d; The large, medium and small dosage group of the present invention is more remarkable to the platelet protective effect, and 3 administration group platelet counts are compared with model group, and difference all has statistical significance (P＜0.05; See Table 3).
The present invention according to the back administration to mouse bone marrow cells dna content, nucleated cell number and the nodular influence of spleen as can be seen from Table 4, irradiation group mouse bone marrow cells dna content descends obviously, compare with matched group, difference has statistical significance (P＜0.05), in, heavy dose of group compares with model group, difference has statistical significance (P＜0.05), illustrates that the present invention has protective effect to bone marrow DNA; And the nucleated cell counting, of the present invention group and model group comparison, difference has statistical significance (P＜0.05), illustrates that the present invention can promote extramedullary hemopoiesis, the protection hemopoietic function of bone marrow; The spleen tuberosity appears in irradiation back mice, and low dose group of the present invention is compared with irradiation control group, and difference has statistical significance (P＜0.05).More than explanation the present invention may be by promoting the hemopoietic stem cell proliferation differentiation, protecting bone marrow DNA to realize to the protective effect of hemopoietic system.
Table 3 the present invention is to the hematoblastic influence (* 10 of radiation murine
12/ L; N=10)
aP＜0.05,
bCompare with model group P＜0.01.
Table 4 the present invention is to the influence of radiation murine bone marrow dna content, nucleated cell number and spleen tuberosity content
aP＜0.05,
bCompare with model group P＜0.01.
3 acute toxicity tests
Press the maximum dosage-feeding algoscopy, medicated powder of the present invention is made into 20% aqueous suspension, to gastric infusion twice in 30 mices, rat one day, accumulated dose is 16g/kg (being equivalent to crude drug in whole 43.2g), observes a week, and the result does not have animal dead.Experiment shows the avirulence of this medicine, can't record its LD to mouse stomach
50One in a few days to the maximum dosage-feeding of mice greater than 16g/kg; This dosage is clinical adult 355 times with dosage (0.045g/kg), proves that this medicine is safe.
Example 2: clinical trial
Guangxi long wave radio station (guidance station) is used 50 people, certain guard station army uses 45 people, take medicine after month two courses of treatment, can improve staff's neurological symptom (memory weakens, visual deterioration, dysphoria, weak, insomnia), cardiovascular symptom (have palpitation, breathe hard), effects such as alopecia.To giddy, dysphoria, hypomnesis, becoming thin has clear improvement, to the effect of being significantly improved of leukocyte, platelet.
By above animal experiment and part clinical observation, find that the present invention has good symptomatic treatment effect to radiation damage, and animal experiment proves it without any toxic action, can use safely.
Claims (4)
1, the medicine of a kind of radiotherapy damage, adopting Chinese medicine is that raw material extracts and forms, and it is characterized in that this medicine is made up of Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae; It is characterized in that by the weight ratio that Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae 4 flavor medical materials are formed being: 5-15 parts of Radix Rhodiolaes, 15-25 parts of the Radixs Astragali, 5-15 parts of Radix Et Caulis Acanthopanacis Senticosis, 80-100 parts of Fructus Hippophaes;
2, the medicine of radiotherapy damage according to claim 1, it is characterized in that being (according to its weight ratio): 10 parts of Radix Rhodiolaes by the optimization ratio that Radix Rhodiolae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Hippophae 4 flavor medical materials are formed, 20 parts of the Radixs Astragali, 10 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 90 parts of Fructus Hippophaes;
3, the medicine of radiotherapy damage according to claim 1 is characterized in that adopting following preparation technology to make capsule: the Radix Astragali and Fructus Hippophae are mixed decocting twice, filter, merging filtrate is concentrated into the extractum of relative density 1.28-1.30 (80 ℃); The Radix Rhodiolae fine powder of gained extractum and Radix Et Caulis Acanthopanacis Senticosi extractum and pulverizing mixes to be mixed thoroughly, and powder is beaten in 60 ℃ of oven dry down, crosses 80 mesh sieves, granulate, and oven dry below 80 ℃, the capsule of packing into No. 0, promptly.
4, according to the medicine of the described radiotherapy damage of producing of claim 3, be used for treating the radiation damage of some light moderates clinically, its usage is every day 3 times, each 3, serveing on for 4 weeks is a course of treatment.
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|---|---|---|---|
| CN2009100213596A CN101485716B (en) | 2009-03-03 | 2009-03-03 | Medicament for treating radiation injury and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357230A (en) * | 2011-11-01 | 2012-02-22 | 山东大学 | Traditional Chinese medicine preparation for treating radiation encephalopathy |
| CN104001149A (en) * | 2014-05-27 | 2014-08-27 | 刘存兵 | Traditional Chinese medicine composition for treating radiation injuries and preparation method thereof |
| CN108813608A (en) * | 2018-05-25 | 2018-11-16 | 陕西黄龙国寿堂生物工程有限公司 | A kind of production method of sea-buckthorn wilsonii cream |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424057A (en) * | 2001-12-10 | 2003-06-18 | 华中科技大学同济医学院附属同济医院 | Chinese medicine immune regulator and its preparation and use in pharmacy |
| CN1286403C (en) * | 2003-09-29 | 2006-11-29 | 吉林市新科奇保健食品有限公司 | Health-care food with immune modulation and cltiradiation function and preparing method thereof |
| CN1742783A (en) * | 2004-08-30 | 2006-03-08 | 北京阜康仁生物制药科技有限公司 | Natural medicine preparatino for tonifying Qi strengthening body resistance and preparing method |
| CN1849927A (en) * | 2006-05-24 | 2006-10-25 | 张彦秋 | Health-care product for relieving fatigue and intensifying immunity and preparing method |
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2009
- 2009-03-03 CN CN2009100213596A patent/CN101485716B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357230A (en) * | 2011-11-01 | 2012-02-22 | 山东大学 | Traditional Chinese medicine preparation for treating radiation encephalopathy |
| CN102357230B (en) * | 2011-11-01 | 2012-11-14 | 山东大学 | Traditional Chinese medicine preparation for treating radiation encephalopathy |
| CN104001149A (en) * | 2014-05-27 | 2014-08-27 | 刘存兵 | Traditional Chinese medicine composition for treating radiation injuries and preparation method thereof |
| CN108813608A (en) * | 2018-05-25 | 2018-11-16 | 陕西黄龙国寿堂生物工程有限公司 | A kind of production method of sea-buckthorn wilsonii cream |
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