CN102357230B - Traditional Chinese medicine preparation for treating radiation encephalopathy - Google Patents
Traditional Chinese medicine preparation for treating radiation encephalopathy Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating radiation encephalopathy, which is prepared by the following raw material herbs by weight: 30-40 parts of ginkgo leaves, 10-15 parts of safflowers, 10-15 parts of rhodiola rosea, 5-10 parts of seaweed, 10-15 parts of laminaria japonica, 5-10 parts of pangolin scales, 15-20 parts of peach kernels, 5-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 5-15 parts of honeysuckles, 10-15 parts of forsythia suspense, 10-20 parts of dandelion, 10-15 parts of violayedoensis, 5-10 parts of hedyotis diffusa willd, and 5-10 parts of radix angelicae. The invention highlights the characteristics of traditional Chinese medicine treatment, has unique curative effect on radiation encephalopathy, and has the advantages of quick effect, stable curative effect, no recurrence and the like. During treatment, the preparation is taken orally, twice a day; one treatment course takes one month; the preparation takes effect generally within 1-2 weeks; and recovery is realized after 2-3 treatment courses.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of radiotherapy encephalopathy (HIE).
Background technology
At present, concerning head-neck malignant tumor, intracranial tumor and cerebrovascular malformation, radiotherapy (abbreviation radiotherapy) is a kind of important treatment means.Since conventional fractionated radiation therapy be applied to clinical after, also the application in clinical is increasing for radiotherapy new equipments such as linear accelerator, χ cutter, γ cutter, photon cutter, the patients clinical curative effect improves constantly, its long-term surviving rate also rises thereupon.Along with patient's prolongation of life cycle, the incidence rate of RE also raises to some extent, and its diagnosis and treatment are the important topics of neuroradiology, neurosurgery and radiation oncology, have caused clinical great attention.
Radiotherapy later six months to 1 year (this phase is also claimed the early stage delayed response phase) is mainly the intracranial hypertension syndrome due to the cerebral edema, and some other neurological symptoms, like convulsions, movement disorder etc.The pathological change of this phase is the arteriolosclerosis degeneration, and luminal stenosis or thrombosis cause cytotoxic brain edema and vasogenic brain edema further to increase the weight of, and causes inaccessible little circumvascular special mess property demyelination district, and necrosis region can occur.
1 year to 17 years (this phase is claimed the delayed response phase in late period again) after the radiotherapy; Clinical manifestation mainly is still intracranial hypertension syndrome and localizing symptoms due to the necrotic lesion and the sign due to the cerebral edema, and brain function decline, mental disorder, visual disorder and carrying out property mental retardation etc. can occur.Main pathology is changed into cerebrovascular degeneration gradually, and particularly small artery vitreous degeneration and cellulose are downright bad, make cranial nerve organize demyelination, and the carrying out property of losing of neuron and dendron increases the weight of.The final cerebral radiation necrosis that forms in a big way.
As a kind of severe complications after the tumor of head and neck radiotherapy, RE is inevitably, and in case its prognosis mala takes place.At present, the method for radiotherapy encephalopathy (HIE) is varied both at home and abroad, but does not still have the specific drugs treatment.Fall ill early stage available megavitamin, neurotrophy medicine (like citicoline, GABA, adenosine triphosphate etc.) reduces the generation of RE as far as possible; A large amount of adrenocortical hormones in treating cerebral edemas, effective percentage reaches 1/3, as, available dexamethasone 10mg～20mg adds 20% mannitol 250mg vein and instils fast, per 6 hours～8 hours 1 time, changes every day 1 time after the remission.But curative effect is unstable mostly, effect is undesirable.
Summary of the invention
To above-mentioned prior art, the invention provides a kind of Chinese medicine preparation of radiotherapy encephalopathy (HIE).
The present invention realizes through following technical scheme:
A kind of Chinese medicine preparation of radiotherapy encephalopathy (HIE) is processed by following bulk drugs: 30～40 parts of Folium Ginkgos, 10～15 parts on Flos Carthami, 10～15 parts of Radix Rhodiolaes; 5～10 parts of Sargassums, 10～15 parts of Thallus Laminariae (Thallus Eckloniae)s, 5～10 parts of Squama Manis, 15～20 parts in Semen Persicae; Triangular 5～15 parts, 10～15 parts of Rhizoma Curcumae, 5～15 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes; 10～20 parts of Herba Taraxacis, 10～15 parts of Herba Violaes, 5～10 parts of Hedyotidis Diffusaes, 5～10 parts of the Radixs Angelicae Dahuricae.
Preferably, process: 30 parts of Folium Ginkgos, 15 parts on Flos Carthami, 10 parts of Radix Rhodiolaes, 10 parts of Sargassums, 10 parts of Thallus Laminariae (Thallus Eckloniae)s by following bulk drugs; 5 parts of Squama Manis, 15 parts in Semen Persicae, triangular 5 parts, 10 parts of Rhizoma Curcumae, 5 parts of Flos Loniceraes; 10 parts of Fructus Forsythiaes, 10 parts of Herba Taraxacis, 15 parts of Herba Violaes, 5 parts of Hedyotidis Diffusaes, 5 parts of the Radixs Angelicae Dahuricae.
Said Sargassum is the Sargassum of the field of Chinese medicines, preferred Da Ye Sargassum.
The method for preparing of the Chinese medicine preparation of said radiotherapy encephalopathy (HIE) is: get each crude drug, place container, soak 25～35min; Use slow fire boiling 80～120min then, cross and filter filtrating, in filtering residue, add water; Reuse slow fire boiling 80～120min; Cross and filter filtrating, twice filtrating merges, and promptly gets oral liquid.Can directly take oral liquid, also can with filtrating after the drying extract, extract is processed tablet or capsule is taken.In case of necessity, can add on the pharmaceutics acceptable carrier and adjuvant to process regular dosage forms such as capsule, tablet or oral liquid.
The Chinese medicine preparation of radiotherapy encephalopathy (HIE) of the present invention, the pharmacological action of each crude drug and compatibility characteristics are summarized as follows:
Folium Ginkgo: nature and flavor are sweet, bitter, puckery, flat, have blood circulation promoting and blood stasis dispelling, analgesic effect.Wherein, flavone (one of main effective ingredient of Folium Ginkgo) is one of the strongest Natural antioxidant, can remove free radical; Reduce the generation and the deposition of MDA and lipofuscin; Improve the activity of superoxide dismutase, the protection cell membrane is regulated organ function of organization.With all medicine phases 5, bring out the best in each other.
Flos Carthami: nature and flavor temperature, hot has pharmacological effects such as blood pressure lowering, antithrombotic, anoxia enduring and immunosuppressant.
Radix Rhodiolae: nature and flavor are sweet, bitter, flat, have effects such as strengthening the body resistance, benefiting qi and removing blood stasis, anti-hypoxia, raise immunity and two-ways regulation.
Sargassum: nature and flavor are salty, cold, have effects such as heat clearing away, softening the hard mass, expectorant, diuretic and detumescent.
Thallus Laminariae (Thallus Eckloniae): nature and flavor are salty, cold, have effects such as hard masses softening and resolving, expectorant and diuretic.
Squama Manis: nature and flavor are salty, and cold has the routed carbuncle of detumescence and searches the demountable effect of wind.
Semen Persicae: nature and flavor are bitter, sweet, flat, have the effect of blood circulation promoting and blood stasis dispelling.
Triangular: nature and flavor are bitter, flat, have effects such as removing blood stasis, circulation of qi promoting and removing food stagnancy pain relieving.
Rhizoma Curcumae: nature and flavor are hot, bitter, warm, have effects such as circulation of qi promoting removing blood stasis and removing food stagnancy pain relieving.
Flos Lonicerae: nature and flavor are sweet, cold, have the effect of heat-clearing and toxic substances removing.
Fructus Forsythiae: nature and flavor are bitter, be slightly cold, and have effects such as heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and dispelling wind and heat pathogens.
Herba Taraxaci: property mildly bitter flavor, cold.Have effects such as heat-clearing and toxic substances removing and dispersing swelling and dissipating binds.
Herba Violae: nature and flavor are bitter, cold, have effects such as clearing away heat-damp and promoting diuresis and removing toxic substances and promoting subsidence of swelling.
Hedyotidis Diffusae: nature and flavor are sweet, cold, have the effect of the immunity of enhancing body.
The Radix Angelicae Dahuricae: warm in nature, the acrid in the mouth of nature and flavor has effects such as the cold expelling of inducing sweat, wind-expelling pain-stopping, dampness leukorrhagia stopping and detumescence and apocenosis.
The present invention is according to China's traditional medical theory, and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is main Therapeutic Principle with blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, the resolving depression of calming the nerves; According to the traditional Chinese medical science " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods " theory; Adopt differential diagnosis of diseases and the dialectical method that combines, found balance treatment, promptly use modern advanced scientific research means; When RE being made clear and definite location, qualitative and quantitative Diagnosis, treat in conjunction with Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs theory.With the disease is guiding principle; Disease is closed ginseng, in clinical treatment, applies to the refined diagnosis technology of macroscopical determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of Chinese medicine and modern medicine among the clinical experimentation; According to the dialectical medication of the state of an illness, comprehensive with the integrity that enriches clinical diagnosis and treatment.
The present invention has given prominence to the characteristic of treatment by Chinese herbs, to the special effect of RE, has advantages such as drug effect is fast, stable curative effect does not recur.During treatment, oral, be a course of treatment at twice, 1 month every day, and general 1～2 week takes effect, and gets final product rehabilitation 2～3 courses of treatment.The therapeutic process noinvasive is painless, and natural Chinese medicines is easy to use, and is without any side effects.This prescription is applicable to the RE due to a variety of causes, through clinical 32 routine patients' clinical verification, and instant effect, determined curative effect, effective percentage high (reaching 93.2%), no complication, long-term effect is good, has certain science, advance and practicality.Raw material sources of the present invention are extensive, super quality and competitive price, and cost is low.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Embodiment 1: get Folium Ginkgo 30g, Flos Carthami 15g, Radix Rhodiolae 10g, Da Ye Sargassum 10g, Thallus Laminariae (Thallus Eckloniae) 10g, Squama Manis 5g, Semen Persicae 15g, triangular 5g, Rhizoma Curcumae 10g, Flos Lonicerae 5g, Fructus Forsythiae 10g, Herba Taraxaci 10g, Herba Violae 15g, Hedyotidis Diffusae 5g, Radix Angelicae Dahuricae 5g.Soak (being as the criterion with submergence) after half an hour with container, reuse slow fire boiling one and a half hours is crossed and is filtered filtrating, adds an amount of water (submergence is as the criterion) in the filtering residue and boils one and a half hours again, filters, and must filtrate, and twice filtrating lumps together, and about 250 milliliters, processes oral liquid.This is one day a consumption, when the patient takes, takes at twice.
Embodiment 2: get Folium Ginkgo 30g, Flos Carthami 15g, Radix Rhodiolae 10g, Da Ye Sargassum 10g, Thallus Laminariae (Thallus Eckloniae) 10g, Squama Manis 5g, Semen Persicae 15g, triangular 5g, Rhizoma Curcumae 10g, Flos Lonicerae 5g, Fructus Forsythiae 10g, Herba Taraxaci 10g, Herba Violae 15g, Hedyotidis Diffusae 5g, Radix Angelicae Dahuricae 5g.Add four times of water gagings and decoct 2 times, each 2h, collecting decoction filters, and filtrate concentrates, and drying is ground impalpable powder, crosses 300 mesh sieves, incapsulates, and promptly processes the Chinese medicinal capsule of radiotherapy encephalopathy (HIE).
Embodiment 3: get Folium Ginkgo 40g, Flos Carthami 10g, Radix Rhodiolae 15g, Sargassum 5g, Thallus Laminariae (Thallus Eckloniae) 15g, Squama Manis 10g, Semen Persicae 20g, triangular 15g, Rhizoma Curcumae 15g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Herba Taraxaci 20g, Herba Violae 10g, Hedyotidis Diffusae 10g, Radix Angelicae Dahuricae 10g.After soaking half an hour with container, reuse slow fire boiling one and a half hours is crossed and is filtered filtrating, adds an amount of water in the filtering residue and boils one and a half hours again, filters, and must filtrate, and twice filtrating lumps together, and about 250 milliliters, process oral liquid, take at twice.
Embodiment 4: get Folium Ginkgo 30g, Flos Carthami 15g, Radix Rhodiolae 10g, lobule Sargassum 10g, Thallus Laminariae (Thallus Eckloniae) 10g, Squama Manis 5g, Semen Persicae 15g, triangular 5g, Rhizoma Curcumae 10g, Flos Lonicerae 5g, Fructus Forsythiae 10g, Herba Taraxaci 10g, Herba Violae 15g, Hedyotidis Diffusae 5g, Radix Angelicae Dahuricae 5g.Add four times of water gagings and decoct 2 times, each 2h, collecting decoction filters, and filtrate concentrates, and with extract and suitable mixed with excipients, processes tablet.
Embodiment 5: Folium Ginkgo 35g, Flos Carthami 13g, Radix Rhodiolae 13g, Sargassum 8g, Thallus Laminariae (Thallus Eckloniae) 13g, Squama Manis 8g, Semen Persicae 18g, triangular 10g, Rhizoma Curcumae 13g, Flos Lonicerae 10g, Fructus Forsythiae 13g, Herba Taraxaci 15g, Herba Violae 13g, Hedyotidis Diffusae 8g, Radix Angelicae Dahuricae 8g.After soaking half an hour with container, reuse slow fire boiling one and a half hours is crossed and is filtered filtrating, adds an amount of water in the filtering residue and boils one and a half hours again, filters, and must filtrate, and twice filtrating lumps together, and about 250 milliliters, process oral liquid, take at twice.
Clinical data:
1. clinical data: be selected from outpatient service and inpatient that in December, 2004 to 2011 has complete data year October totally 65 examples; Be patient with brain tumors; And carried out radiotherapy; Revealing in various degree headache, diplopia, drowsiness, hypomnesis, symptom such as dull, indifferent, is RE through iconography or clinical diagnosis.Be divided into treatment at random and organize 32 examples, matched group 33 examples.The treatment group age is 18～65 years old, average 43.0 ± 12.4 years old, wherein, male 18 examples, women 14 examples; The matched group age is 20～61 years old, average 42.9 ± 10.6 years old, wherein, male 20 examples, women 13 examples.Sex (χ between two groups
2=0.13, P=0.72) and age (t=0.01, P=0.99) equal no difference of science of statistics.
2. Therapeutic Method: the treatment group is oral meal sooner or later with prescription medicament of the present invention (embodiment 1 preparation), and 1 month is a course of treatment.Matched group intravenous drip citicoline, 200mg～600mg/l day; Oral GABA, 1g/3 time; Oral adenosine triphosphate, 20mg～60mg/ time, 3 times/day; Can add 20% mannitol 250mg vein with dexamethasone 10mg～20mg during cerebral edema and instil per 6 hours～8 hours 1 time fast.
3. result and statistical method: whether criterion of therapeutical effect is to estimate clinical symptoms to alleviate or disappear, and the project of observation comprises hypomnesis, intelligence decline, abstract thinking obstacle, aphasia agnosia, personality changes, disturbance in judgement, dystropy, individual character is unsociable and eccentric and reading writing is difficult.Cure: same or similar before its clinical symptoms and the radiotherapy; Treatment is effectively: in various degree improvement before its clinical symptoms is taken medicine; Fail to respond to any medical treatment: the preceding deterioration of taking medicine of its clinical symptoms.Effective percentage=(curing number+significant figure)/total routine number * 100%.
Effective percentage uses accurate probabilistic method to compare between two groups, sees shown in the table l.
Table 1 liang group cure rate synopsis
Annotate: the accurate probabilistic method of effective percentage compares P=0.034 between two groups
4. side effect and contraindication:
(1) side effect:, do not find obvious toxic-side effects through the 32 routine patients clinical observation of curative effect in 6 years.
(2) contraindication: anemia of pregnant woman and allergic constitution patient forbidding.
Case:
1. Lee, the man 55 years old, in May, 2004 occurs headache, vomiting, papilloedema, epilepsy; Frontal lobe was seen the lamellar low-density shadow on the left of the scanning of CT head was shown, strengthened scanning and showed the about 3cm * 3.5cm of lump size, and through the capable tumorectomy of cranium approach, pathological diagnosis is a glioma III-IV level; The row radiotherapy of 5 week of postoperative, line source is a linear accelerator, exposure dose is 60Gy, in JIUYUE, 2005 occurs headache companion vomiting; The long T2 signal change of long Tl in the white matter of frontal lobe of left side is shown in row MRI inspection, is diagnosed as tardy property RE, takes oral liquid of the present invention then; Symptom is controlled after 2 weeks, and basic the recovery normally followed up a case by regular visits to the no abnormality seen symptom after 1 year after 1 course of treatment.
2 Wang, the man, 32 years old, headache, vomiting appear in February, 2000, and the scanning of CT head shows that the right side top sees the lamellar low-density shadow; Strengthen scanning and show the about 2.5cm * 3cm of lump size, through the capable tumorectomy of cranium approach, pathological diagnosis is an anaplastic astroglioma level, postoperative capable radiotherapy in 1 month; Line source is a linear accelerator, and exposure dose is 60Gy, in May, 2009 occurs headache, the row CT examination; Show and see the lamellar low-density shadow in the top of right side, it is clear that owe on the border, do not see obvious reinforcement, is diagnosed as tardy property RE; Take capsule of the present invention then, 1 week back headache is able to control, continue to take 2 courses of treatment after, recover normal; Followed up a case by regular visits in 3 months, symptom does not have recurrence.
3 Liu, the woman, 52 years old, suffer from headaches 1 year surplus, insomnia and dreamful sleep, epilepsy.MRI head scanning in June nineteen ninety-five shows that the left side temporal lobe sees the long T2 abnormal signal of the long T1 of lamellar, and reinforcement scans shows that lump do not see obvious reinforcement, and through the capable tumorectomy of cranium approach, pathological diagnosis is an astrocytoma II-III level; Postoperative capable radiotherapy in 1 month, line source is a linear accelerator, exposure dose is 60Gy, in July, 2006 occurs headache; The long T2 abnormal signal of the left side long T1 of temporal lobe is shown in row MRI inspection, and it is clear that owe on the border; Be " pattern " and strengthen, be diagnosed as tardy property RE, take oral liquid of the present invention then; Headache is able to alleviate after 6 days, and the transference cure of having a headache after 3 courses of treatment continues to take and consolidates curative effect 1 course of treatment.No headache symptom after 2 years.
4 Zhangs, the woman, 38 years old, have a headache 2 years surplus; Temporal lobe was seen the long T2 abnormal signal of the long T1 of lamellar on the left of row MRI head scanning in August calendar year 2001 was shown, strengthened scanning and showed the about 4 * 4.1cm of lump size, and through the capable tumorectomy of cranium approach, pathological diagnosis is a glioblastoma multiforme; The row radiotherapy of 6 week of postoperative, line source is a linear accelerator, exposure dose is 60Gy, in June, 2008 occurs headache; The long T2 abnormal signal of the left side long T1 of temporal lobe is shown in row MRI inspection, and it is clear that owe on the border, is slight Heterogeneous enhancement; Be diagnosed as tardy property RE, take tablet of the present invention then, the basic recovery in 2 week backs normally followed up a case by regular visits to after 1 year and do not seen recurrence.
5 Zhao, the man, 47 years old, headache, vomiting, papilloedema appearred in December in 1991, and slightly high density shadow of tricorn trigonum, right side is shown in the scanning of CT head; Strengthen scanning and show the about 4cm * 4.5cm of lump size, through the capable tumorectomy of cranium approach, pathological diagnosis is the anaplastic ependymoma, 1 month capable radiotherapy of postoperative; Line source is a linear accelerator, and exposure dose is 60Gy, in November, 2008 occurs headache, blurring of vision; The long T2 signal change of the right side pillow long Tl of top is shown in row MRI inspection, does not see obvious reinforcement, and it is clear that owe on the border; Be diagnosed as tardy property RE, take oral liquid of the present invention then, headache transference cure after 2 courses of treatment does not have recurrence after 2 years.
Claims (5)
1. the Chinese medicine preparation of a radiotherapy encephalopathy (HIE) is characterized in that, is processed by following bulk drugs: 30～40 parts of Folium Ginkgos, 10～15 parts on Flos Carthami, 10～15 parts of Radix Rhodiolaes; 5～10 parts of Sargassums, 10～15 parts of Thallus Laminariae (Thallus Eckloniae)s, 5～10 parts of Squama Manis, 15～20 parts in Semen Persicae; Triangular 5～15 parts, 10～15 parts of Rhizoma Curcumae, 5～15 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes; 10～20 parts of Herba Taraxacis, 10～15 parts of Herba Violaes, 5～10 parts of Hedyotidis Diffusaes, 5～10 parts of the Radixs Angelicae Dahuricae.
2. the Chinese medicine preparation of a kind of radiotherapy encephalopathy (HIE) according to claim 1 is characterized in that, is processed by following bulk drugs: 30 parts of Folium Ginkgos, 15 parts on Flos Carthami, 10 parts of Radix Rhodiolaes; 10 parts of Sargassums, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 5 parts of Squama Manis, 15 parts in Semen Persicae; Triangular 5 parts, 10 parts of Rhizoma Curcumae, 5 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes; 10 parts of Herba Taraxacis, 15 parts of Herba Violaes, 5 parts of Hedyotidis Diffusaes, 5 parts of the Radixs Angelicae Dahuricae.
3. the Chinese medicine preparation of a kind of radiotherapy encephalopathy (HIE) according to claim 1 is characterized in that, is processed by following bulk drugs: 40 parts of Folium Ginkgos, 10 parts on Flos Carthami, 15 parts of Radix Rhodiolaes; 5 parts of Sargassums, 15 parts of Thallus Laminariae (Thallus Eckloniae)s, 10 parts of Squama Manis, 20 parts in Semen Persicae; Triangular 15 parts, 15 parts of Rhizoma Curcumae, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes; 20 parts of Herba Taraxacis, 10 parts of Herba Violaes, 10 parts of Hedyotidis Diffusaes, 10 parts of the Radixs Angelicae Dahuricae.
4. the Chinese medicine preparation of a kind of radiotherapy encephalopathy (HIE) according to claim 1 is characterized in that, is processed by following bulk drugs: 35 parts of Folium Ginkgos, 13 parts on Flos Carthami, 13 parts of Radix Rhodiolaes; 8 parts of Sargassums, 13 parts of Thallus Laminariae (Thallus Eckloniae)s, 8 parts of Squama Manis, 18 parts in Semen Persicae; Triangular 10 parts, 13 parts of Rhizoma Curcumae, 10 parts of Flos Loniceraes, 13 parts of Fructus Forsythiaes; 15 parts of Herba Taraxacis, 13 parts of Herba Violaes, 8 parts of Hedyotidis Diffusaes, 8 parts of the Radixs Angelicae Dahuricae.
5. the method for preparing of the Chinese medicine preparation of the described a kind of radiotherapy encephalopathy (HIE) of claim 1 is characterized in that: get each crude drug, place container; Soak 25～35min, use slow fire boiling 80～120min then, cross and filter filtrating; In filtering residue, add water, reuse slow fire boiling 80～120min crosses and filters filtrating; Twice filtrating merges, and promptly gets.
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