CN104971306B - A kind of Traditional Chinese medicine compound composition for treating atrophic gastritis and precancerous lesion and preparation method thereof and preparation - Google Patents
A kind of Traditional Chinese medicine compound composition for treating atrophic gastritis and precancerous lesion and preparation method thereof and preparation Download PDFInfo
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Abstract
The present invention relates to drug field, especially a kind of Traditional Chinese medicine compound composition for treating atrophic gastritis and precancerous lesion and preparation method thereof and preparation.The Traditional Chinese medicine compound composition for treating atrophic gastritis and precancerous lesion, consists of the following compositions: rhizoma atractylodis macrocephalae, polyporus lucidus, curcuma zedoary, stir-baked RADIX PAEONIAE ALBA, burnt ochre, Artemisia anomala and oldenlandia diffusa.Traditional Chinese medicine compound composition of the invention has the clinical symptoms for improving patient, and mucosal inflammation under gastroscope, activity is mitigated or eliminated, and blocks and reverse part atrophy, the effect of light moderate intestines, slight dysplasia.It provides that the applicable atrophic gastritis of composition and precancerous lesion patient have following clinical symptoms: stomach discomfort, or pain or swollen, is not cured, gets along well in simultaneous or mouth repeatedly, stool or knot or half congealed, sleep is felt unwell, depression or irritated, and thin lingual fur is yellow or thin net, there is crackle, sublingual train of thought is purple dark, and pulse condition string is sliding.
Description
Technical field
The present invention relates to drug field, especially a kind of Chinese medicine compound prescription group for treating atrophic gastritis and precancerous lesion
Close object and preparation method thereof and preparation.
Background technique
Atrophic gastritis (chronic atrophic gastritis, CAG) is one kind with the intrinsic body of gland of stomach lining
Atrophy and intestinal metaplasia are the digestive disease of lesion characteristics.It includes: atrophy, intestines, dysplasia etc. that gastric cancer, which becomes lesion,.Stomach
Mucous membrane canceration is multi-step, a progressive process, before developing as malignant tumour, is often changed before experience cancer lasting for many years.
China is the high Infected regions of atrophic gastritis, and crowd's gastroscope recall rate is 7.5% ~ 13.8%, and follow-up has closely after 10 ~ 20 years
Gastric cancer occurs for 8% case.Therefore the intervention blocking treatment for implementing atrophic gastritis and precancerous lesion canceration, to reduction gastric cancer
Incidence has practical significance.
At present western medicine to the therapeutic purposes of atrophic gastritis and precancerous lesion be improve gastric mucosal histology (including
Atrophy, intestines and dysplasia etc.).Primary treatment measure includes: to eradicate helicobacter pylori, and can improve atrophic gastritis cancer
Preceding lesion drug.Current certified key agents have: folic acid can reduce the risk that gastric cancer occurs；Natural carrot is known as inverse
Turn the effect of dysplasia；Tea polyphenols can induce gastric carcinoma cells apoptosis；Other such as Cyclooxygenase-2 Inhibitor, antioxidant all
It is more promising reverse means, but still needs to further investigation and clinical verification.Traditional Chinese medicine is in treatment including dysplasia
A large amount of clinical practices have been carried out in terms of atrophic gastritis and precancerous lesion, have proposed strengthening the spleen and replenishing qi, activating microcirculation and removing stasis medicinal, yin-nourishing increasing
A variety of therapies such as liquid, qi-regulating dissipate-swelling, clearing heat and detoxicating, resolving phlegm and softening hard masses, wherein being with invigorating spleen and reinforcing stomach, promoting blood circulation and removing obstruction in channels, detoxicating and resolving a mass again
Substantially big method.
The interpretation of the cause, onset and process of an illness of atrophic gastritis and precancerous lesion is intricate, traditional Chinese medicine mostly by this disease belong to " epigastric pain ",
Scopes such as " feeling of fullness ", lesion are and closely related with liver, spleen etc. often based on stomach.In the dynamic volt shelf theory of " poison card opinion " poison card and
Think under " menses disease is discussed and clinic " menarche mind theoretical direction, the imbalance of menarche mind causes stomach film folder stasis of blood folder poison to be the master of this disease
Want the interpretation of the cause, onset and process of an illness.Menarche mind is derived from brain system, has commander's effect to viscera function, including The spleen has the function to transport and transform nutrients, stomach receiving food and drink, liver controlling conveyance and dispersion
Deng with menarche mind it is closely related, by regulate and control liver and spleen stomach normal function, promote the normal defeated cloth of qi-blood-body fluid.Work as menses
To when mind imbalance, the adjustment effect to liver and spleen stomach is lost, causes all evil stagnant difficulties of heap soil or fertilizer over and around the roots to be dispelled, yin consumption is sought in functional activity of QI being not smooth, ecchymosis internal resistance
Damage, stomach film, which loses, causes this disease in nourishing.Therefore, " spleen is helped to pacify stomach, stagnation resolvation detoxification " is treatment atrophic gastritis and precancerosis
The effective ways of change.
Summary of the invention
Based on above-mentioned Basic Theories of Chinese Medicine and clinical verification, chronic wither is treated the first purpose of the invention is to provide a kind of
The Traditional Chinese medicine compound composition of contracting gastritis and precancerous lesion, the rehabilitation for atrophic gastritis and precancerous lesion patient mention
For new medicament selection.A second object of the present invention is to provide a kind of Chinese medicines for treating atrophic gastritis and precancerous lesion
The decocting method of compound.Atrophic gastritis and precancerous lesion are treated third object of the present invention is to provide a kind of
Chinese materia medica preparation.
In order to realize first above-mentioned purpose, present invention employs technical solutions below:
Treat the Traditional Chinese medicine compound composition of atrophic gastritis and precancerous lesion, the Traditional Chinese medicine compound composition it is effective at
The raw medicinal material divided consists of the following compositions according to parts by weight:
5 ~ 25 parts of rhizoma atractylodis macrocephalae, 5 ~ 35 parts of polyporus lucidus, 6 ~ 18 parts of curcuma zedoary, 5 ~ 30 parts of stir-baked RADIX PAEONIAE ALBA, 6 ~ 18 parts of burnt ochre, Artemisia anomala
6 ~ 18 parts, 10 ~ 35 parts of oldenlandia diffusa.
Preferably, the raw medicinal material of the effective component of the Traditional Chinese medicine compound composition is according to parts by weight by following component group
At:
12 ~ 18 parts of rhizoma atractylodis macrocephalae, 12 ~ 18 parts of polyporus lucidus, 6 ~ 15 parts of curcuma zedoary, 12 ~ 18 parts of stir-baked RADIX PAEONIAE ALBA, 6 ~ 15 parts of burnt ochre, Liu
Post 10 ~ 15 parts of slave, 12 ~ 18 parts of oldenlandia diffusa.
As most preferably, the raw medicinal material of the effective component of the Traditional Chinese medicine compound composition is according to parts by weight by following component
Composition:
15 parts of rhizoma atractylodis macrocephalae, 15 parts of polyporus lucidus, 9 parts of curcuma zedoary, 15 parts of stir-baked RADIX PAEONIAE ALBA, 9 parts of burnt ochre, 12 parts of Artemisia anomala, agkistrodon
15 parts of tongue grass.
In order to realize second above-mentioned purpose, present invention employs technical solutions below:
A kind of decocting method of above-mentioned Traditional Chinese medicine compound composition, includes the following steps: in this method in raw medicinal material
The middle water that 10 times of amounts are added, decocts and extracts 1 hour, filtration；Filter residue adds the water of 5 times of amounts again, decocts and extracts 0.5 hour, filtration；It closes
And 2 filtrates, it is concentrated into the decocting liquid that volume is 300-400 mL.
In order to realize above-mentioned third purpose, present invention employs technical solutions below:
A kind of Chinese materia medica preparation for treating atrophic gastritis and precancerous lesion, the preparation is by above-mentioned pharmaceutical composition
Object and necessary preparation are prepared with auxiliary material.
Preferably, the preparation is oral agents described in any pharmacy.
As further preferably, the oral agents are tablet, capsule, granule, soft extract, powder, pill, soft capsule
One of with pill.
Due to the adoption of the above technical solution, the present invention provides one kind by " spleen peace stomach, stagnation resolvation being helped to pull out by the present invention
Poison " treatment is lacked of proper care based on menarche mind, and liver and spleen loses in adjusting stomach, causes stomach membrane damage, ecchymosis internal resistance.Symptoms include stomach discomfort, or
Pain is swollen, is not cured repeatedly, and or mouth in get along well, defecate or tie or half congealed, sleep is felt unwell, depression or irritated, and thin lingual fur is yellow or thin net,
There is crackle, sublingual train of thought is purple dark, the sliding atrophic gastritis of pulse condition string and precancerous lesion Chinese prescription.Rhizoma atractylodis macrocephalae invigorating the spleen in side
Removing dampness to restore normal functioning of the stomach, polyporus lucidus are pacified to mind, nourishing the stomach gas, and stir-baked RADIX PAEONIAE ALBA supports spleen yin, protects stomach film, close and spleen can be helped to protect stomach, prevent ecchymosis metaplasia,
For main ingredient in side；For burnt ochre gently to drop turbid poison, curcuma zedoary is few to dissolving stasis poison, oldenlandia diffusa energy heat-clearing poison, Artemisia anomala promoting blood circulation
Activating collaterals and eliminating stagnation is adjuvant in side.All medicines are harmonious, and focus on maintenance to mind, spleen is helped to pacify stomach, stagnation resolvation detoxification.To treat chronic atrophy
Property gastritis and precancerous lesion provide new medicament selection, facilitate the improvement and rehabilitation of patient symptom.
Traditional Chinese medicine compound composition of the invention has the clinical symptoms for improving patient, and mucositis under gastroscope is mitigated or eliminated
Disease, activity block and reverse part atrophy, the effect of light moderate intestines, slight dysplasia.Provide that composition is applicable in slow
Property atrophic gastritis and precancerous lesion patient have following clinical symptoms: stomach discomfort, or pain or it is swollen, be not cured repeatedly, and or mouth
Middle discord, stool or knot or half congealed, sleep is felt unwell, depression or irritated, and thin lingual fur is yellow or thin net, has crackle, sublingual train of thought is purple dark, arteries and veins
As string is sliding.
Detailed description of the invention
Fig. 1 is that gastroscope following table is existing before treating: antrum is red and white, sees and is dispersed in erythema and hickie, and rete vasculosum is clearly visible.Mirror
Lower diagnosis: Chronic Moderate atrophic gastritis accompanied is rotten to the corn.
Fig. 2 is to show under gastroscope after treating: antrum is red and white, and a small amount of hickie, rete vasculosum mays be seen indistinctly.It is diagnosed under mirror:
Chronic mild atrophic gastritis accompanied is rotten to the corn.
Fig. 3 is pathological manifestations before treating: antral gastric mucosa chronic inflammation is with slight atrophy, moderate intestines, slight dysplasia.
Fig. 4 is pathological manifestations after treatment: antral gastric mucosa chronic inflammation is with slight intestines.
Specific embodiment
1, efficacy effect is evaluated
1) rhizoma atractylodis macrocephalae 15g, polyporus lucidus 15g, curcuma zedoary 9g, stir-baked RADIX PAEONIAE ALBA 15g, burnt ochre 9g, Artemisia anomala 12g, oldenlandia are taken
Careless 15g.The water of 900mL is added, decocts and extracts 1 hour, filtration；Filter residue adds the water of 450mL again, decocts and extracts 0.5 hour, filter
It crosses；Merge 2 filtrates, filtrate heats the concentrate for being concentrated into 450mL, is divided into 2 parts of isometric decocting liquids, spare；
2) be included in case meet 2012 Chinese Medical Association's disease for digest credit meeting " Chinese National Consensus on Chronic Gastritis " it is slow
Property atrophic gastritis and precancerous lesion diagnostic criteria, Standards of Chinese Medical Syndrome Differentiation meet menarche mind imbalance, liver and spleen to stomach lose in tune
Section causes stomach membrane damage, ecchymosis internal resistance symptoms include stomach discomfort, or pain or swollen, is not cured repeatedly, and or mouth in get along well, defecate or tie or
Half congealed, sleep is felt unwell, depression or irritated, and thin lingual fur is yellow or thin net, has crackle, sublingual train of thought is purple dark, and pulse condition string is sliding；
3) clinical patient 90 for meeting step 2, are randomly divided into treatment group 60, and control group 30.Treatment group, which is given, to be walked
Rapid concentrate 1), each taking 225ml, 2 times a day.Control group gives Couteat of Folic Acid, each 10mg, 3 times a day.One course for the treatment of
It is 28 days, continuously takes 3 course for the treatment of, observes clinical symptoms, tcm syndrome curative effect, gastroscope and the pathological tissue of pretherapy and post-treatment patient
Learn integral variation.
4) gastroscope and pathology curative effect determinate standard:
Cure: gastroscope checks Active inflammation and disappears, and chronic inflammation improves up to slight；Body of gland atrophy, intestinal metaplasia and abnormal shape
Hyperplasia disappears.
Effective: mucous membrane acute inflammation disappears substantially, and chronic inflammation improves；Body of gland atrophy, intestinal metaplasia and dysplasia are obvious
Mitigate.
Effective: 1/2 or more non-cancer lesion range shorter, inflammation is mitigated；Body of gland atrophy, intestinal metaplasia and dysplasia subtract
Gently.
It is invalid: without improvement person seen in scope and pathology.
5) tcm syndrome efficacy assessment standard:
Recovery from illness: clinical symptoms disappear substantially, and syndrome integral reduces >=95%；
Effective: clinical symptoms significantly reduce, and syndrome integral reduces >=70%；
Effective: clinical symptoms are reduced, and syndrome integral reduces >=30%；
Invalid: for clinical symptoms without reducing or slightly reducing, syndrome integral reduces < 30%.
6) general curative effect evaluation criterion
Clinical cure: clinical primary symptom shape disappears, and minor symptom disappears or disappears substantially；Gastroscope checks Active inflammation and disappears, slowly
Property inflammation improve up to slight；Seen in biopsy proved by pathology gastroscope, body of gland atrophy, intestines and dysplasia subside or disappear；
Effective: clinical primary symptom shape disappears, and secondary symptom disappears substantially；Gastroscope check mucous membrane acute inflammation disappears substantially, chronic
Inflammation improves；Seen in biopsy proved by pathology gastroscope, body of gland atrophy, intestines and dysplasia are substantially reduced；
Effective: primary symptom shape is substantially reduced；1/2 or more gastrocopy non-cancer lesion range shorter, inflammation is mitigated；Biopsy
Histopathology confirms that seen in gastroscope, Acute and chronic inflammation mitigates, and body of gland atrophy, intestines and dysplasia mitigate；
Invalid: symptom, scope, pathology are without improvement person.
7) assessment result for taking step 4), step 5), step 6) analyzes software using SPSS, carries out data statistics credit
Analysis, the results are shown in Table 1, attached drawing 1 ~ 4, the results showed that, non-cancer lesion, Histopathology curative effect are superior to compare under the gastroscope for the treatment of group
Group (P< 0.05), being mainly reflected in improves non-cancer lesion, chronic inflammation under gastroscope, reverses atrophy, light moderate intestines, slight abnormal shape
Hyperplasia etc..The total effective rate 71.67%(43/60 for the treatment of group), the total effective rate better than control group is 46.67%(14/
30) (P<0.05).The tcm syndrome efficacy response rate 81.67%(49/60 for the treatment of group), it is better than control group effective percentage 56.67%
(17/30) (P<0.05)。
The comparison (`X ± S) of Mucosal atrophy, intestines, dysplasia, inflammation, activity integral after 1 two groups of treatments of table
| Group | Number of cases | Atrophy | Light moderate intestines | Slight dysplasia | Chronic inflammation | Activity |
| Treatment group | 60 | 2.10±1.43 | 2.10±1.80 | 0.20±1.25 | 1.20±0.77 | 0.83±0.41 |
| Control group | 30 | 2.90±1.92* | 3.00±1.76* | 0.80±1.04* | 1.53±0.56* | 1.07±0.65* |
Note: two comparison among groups:* P<0.05。
2, the clinical application method of Traditional Chinese medicine compound composition, comprising the following steps:
1) rhizoma atractylodis macrocephalae 150g, polyporus lucidus 150g, curcuma zedoary 90g are taken, stir-baked RADIX PAEONIAE ALBA 150g, burnt ochre 90g, Artemisia anomala 120g is white
Flower HERBA HEDYOTIS DIFFUSAE 150g.The water of 9000mL is added, decocts and extracts 1 hour, filtration；Filter residue adds the water of 4500mL again, decocts and extracts 0.5
Hour, filtration；Merge 2 filtrates, filtrate heats the concentrate for being concentrated into 4500mL, is divided into 20 parts of isometric decocting liquids, standby
With；
2) according to atrophic gastritis and precancerous lesion clinical symptoms, gastroscope and pathologic finding, patient is diagnosed, specifically
Index includes: that patient master states: stomach discomfort, or pain or swollen, is not cured repeatedly, and or mouth in get along well, defecate or tie or half congealed, sleep is owed
Peace, depression or irritated, thin lingual fur is yellow or thin net, has crackle, sublingual train of thought is purple dark, and pulse condition string is sliding.Gastroscope and pathology: chronic mucous membrane
Inflammation, atrophy, intestines, dysplasia；
3) through patient 10 that clinical diagnosis is atrophic gastritis and precancerous lesion, daily respectively at breakfast and dinner
Half an hour after takes the decocting liquid of step 1), warmly takes.One course for the treatment of is 28 days, is continuously taken 3 course for the treatment of.
Claims (6)
1. a kind of Traditional Chinese medicine compound composition for treating atrophic gastritis and gastric precancerous lesion, it is characterised in that: the Chinese medicine is multiple
The raw medicinal material of the effective component of square composition consists of the following compositions according to parts by weight: 12 ~ 18 parts of rhizoma atractylodis macrocephalae, polyporus lucidus
12 ~ 18 parts, 6 ~ 15 parts of curcuma zedoary, 12 ~ 18 parts of stir-baked RADIX PAEONIAE ALBA, 6 ~ 15 parts of burnt ochre, 10 ~ 15 parts of Artemisia anomala, oldenlandia diffusa 12 ~ 18
Part.
2. a kind of Traditional Chinese medicine compound composition for treating atrophic gastritis and gastric precancerous lesion according to claim 1,
It is characterized in that the raw medicinal material of the effective component of the Traditional Chinese medicine compound composition consists of the following compositions according to parts by weight: frying
15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of polyporus lucidus, 9 parts of curcuma zedoary, 15 parts of stir-baked RADIX PAEONIAE ALBA, 9 parts of burnt ochre, 12 parts of Artemisia anomala, oldenlandia diffusa
15 parts.
3. a kind of decocting method of Traditional Chinese medicine compound composition, it is characterised in that: this method includes the following steps: to take rhizoma atractylodis macrocephalae
15g, polyporus lucidus 15g, curcuma zedoary 9g, stir-baked RADIX PAEONIAE ALBA 15g, burnt ochre 9g, Artemisia anomala 12g, oldenlandia diffusa 15g；It is added 900mL's
Water is decocted and is extracted 1 hour, filtration；Filter residue adds the water of 450mL again, decocts and extracts 0.5 hour, filtration；Merge 2 filtrates,
Filtrate heats the concentrate for being concentrated into 450mL.
4. a kind of Chinese materia medica preparation for treating atrophic gastritis and gastric precancerous lesion, it is characterised in that the preparation is by right
It is required that pharmaceutical composition described in 1 or 2 and pharmaceutically acceptable auxiliary material are prepared.
5. a kind of Chinese materia medica preparation for treating atrophic gastritis and gastric precancerous lesion according to claim 4, feature
It is that the preparation is oral agents described in any pharmacy.
6. a kind of Chinese materia medica preparation for treating atrophic gastritis and gastric precancerous lesion according to claim 5, feature
It is that oral agents are one of tablet, capsule, granule, soft extract, powder, pill and pill.
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| CN1129123A (en) * | 1995-02-14 | 1996-08-21 | 李寿山 | Stomach recovering medicine |
| JP2004115536A (en) * | 2003-11-27 | 2004-04-15 | Rohto Pharmaceut Co Ltd | Anti-helicobacter pylori activator |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129123A (en) * | 1995-02-14 | 1996-08-21 | 李寿山 | Stomach recovering medicine |
| JP2004115536A (en) * | 2003-11-27 | 2004-04-15 | Rohto Pharmaceut Co Ltd | Anti-helicobacter pylori activator |
Non-Patent Citations (2)
| Title |
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| 安胃汤治疗慢性萎缩性胃炎;李毅平;《湖北中医杂志》;20031231;第25卷(第7期);第45-46页，尤其是第45页右栏第1和3段 * |
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