CN103768434A - Traditional Chinese medicine for enhancing laying rate of laying hens and preparation method thereof - Google Patents
Traditional Chinese medicine for enhancing laying rate of laying hens and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for enhancing laying rate of laying hens and a preparation method thereof. The traditional Chinese medicine is prepared from the following active pharmaceutical ingredients: acanthopanax, wolfberry fruit, radix astragali, Potentilla anserina, rhizoma arundinis, Canscora lucidissima, hartshorn, safflower, Rhizoma Blechni, motherwort, hawthorn, Polygala arillata root, schisandra fruit, Arillus Longan, fructus psoraleae, Aralia elata and decumbent corydalis tuber. The traditional Chinese medicine feed additive added to a traditional feed in the percentage of 1-2% can obviously enhance the laying rate of laying hens, and can obviously improve the average egg weight, yolk index, yolk percentage, material/egg ratio and other laying properties. The traditional Chinese medicine feed additive can be further combined with a proper amount of melatonin, and can also enhance the laying rate of laying hens and improve the average egg weight of the laying hens, material/egg ratio and other laying properties.
Description
Technical field
The present invention relates to contain the cultivated animals feed additive that derives from plant, animal or mineral component, relate in particular to a kind of Chinese medicine that improves laying rate of laying hen and preparation method thereof.
Background technology
Along with aquaculture scale is constantly magnified, feed additive has become one of neccessary composition in animal diets.The correct waste that uses feed additive can effectively reduce nutrient substance, promotes absorbing of nutrition, improves the price of deed, reduces cost, promotes animal growth and development, obtains good fertility performance and good economic benefit.
But, along with a large amount of chemosynthesis feed additive and chemical drugs, as antibiotic, somatotropin and antiseptic etc. generally use in feedstuff, when having played certain impetus to animal husbandry development, they also bring larger negative effect, particularly antibiotic a large amount of use, the drug resistance of its generation and drug residue have brought great harm to human health, have caused concern and the worry of the whole society.Along with the raising of China's animal food sanitary standard, feed safety is the primary condition that guarantees animal based food safety; And development pollution-free green food has also become the task of top priority of aquaculture.Chinese medicine is as feed additive, with it without features such as Drug resistance, pollution-free and exclusive two-ways regulations and gradually by people are paid attention to.
Aviculture is one of important component part of world's aquaculture, is also one of important sources of human animal's property food, and therefore, the safety of feed additive, is directly connected to the health of the mankind in next link of food chain.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine that improves laying rate of laying hen and preparation method thereof is provided, and Chinese medicine of the present invention can significantly improve the laying rate of laying hen, improves the quality of egg laying performance and the egg that laying hen produces of laying hen.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine that improves laying rate of laying hen, the each raw medicinal material of described Chinese medicine comprises: Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, the Radix Astragali, Radix potentillae anserinae, Rhizoma Arundinis Donacis, Herba Canscorae, Cornu Cervi Pantotrichum, Flos Carthami, Oriental Blechnum Fern Rhizome, Herba Leonuri, Fructus Crataegi, Radix polygalae arillatae, Fructus Schisandrae Chinensis, Arillus Longan, Fructus Psoraleae, thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentis.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can be as follows: 30～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～30 parts of Fructus Lycii, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix potentillae anserinae, 5～10 parts of Rhizoma Arundinis Donaciss, 8～15 parts of Herba Canscoraes, 10～20 parts, Cornu Cervi Pantotrichum, 15～25 parts, Flos Carthami, 5～10 parts of Oriental Blechnum Fern Rhizomes, 20～30 parts of Herba Leonuris, 25～35 parts of Fructus Crataegis, 10～20 parts of Radix polygalae arillatae, 15～25 parts of Fructus Schisandrae Chinensis, 10～20 parts of Arillus Longans, 20～30 parts of Fructus Psoraleaes, 5～10 parts of 5～15 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can also be preferably as follows: 35～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 25～30 parts of Fructus Lycii, 15～20 parts of the Radixs Astragali, 10～15 parts of Radix potentillae anserinae, 5～8 parts of Rhizoma Arundinis Donaciss, 8～10 parts of Herba Canscoraes, 10～15 parts, Cornu Cervi Pantotrichum, 15～20 parts, Flos Carthami, 8～10 parts of Oriental Blechnum Fern Rhizomes, 25～30 parts of Herba Leonuris, 25～30 parts of Fructus Crataegis, 10～15 parts of Radix polygalae arillatae, 20～25 parts of Fructus Schisandrae Chinensis, 15～20 parts of Arillus Longans, 20～25 parts of Fructus Psoraleaes, 5～7 parts of 5～10 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can be preferably as follows again: 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Lycii, 16 parts of the Radixs Astragali, 12 parts of Radix potentillae anserinae, 6 parts of Rhizoma Arundinis Donaciss, 9 parts of Herba Canscoraes, 13 parts, Cornu Cervi Pantotrichum, 18 parts, Flos Carthami, 9 parts of Oriental Blechnum Fern Rhizomes, 29 parts of Herba Leonuris, 28 parts of Fructus Crataegis, 10 parts of Radix polygalae arillatae, 23 parts of Fructus Schisandrae Chinensis, 17 parts of Arillus Longans, 22 parts of Fructus Psoraleaes, 7 parts of 8 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine also can be preferably as follows: 38 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Fructus Lycii, 18 parts of the Radixs Astragali, 14 parts of Radix potentillae anserinae, 7 parts of Rhizoma Arundinis Donaciss, 8 parts of Herba Canscoraes, 11 parts, Cornu Cervi Pantotrichum, 16 parts, Flos Carthami, 10 parts of Oriental Blechnum Fern Rhizomes, 25 parts of Herba Leonuris, 27 parts of Fructus Crataegis, 12 parts of Radix polygalae arillatae, 21 parts of Fructus Schisandrae Chinensis, 15 parts of Arillus Longans, 24 parts of Fructus Psoraleaes, 5 parts of 6 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, in described Chinese medicine, can also further include the melatonin of 8～15mg/kg.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Wherein, described preparation method is further comprising the steps of:
The 4th step, the described powder that the 3rd step is obtained is mixed homogeneously with described melatonin.
Beneficial effect of the present invention: by by Chinese medicine feed additive of the present invention with 1%～2% ratio, add in traditional feedstuff, the laying rate of laying hen can be significantly improved, the egg laying performances such as average egg weight, yolk index, egg yolk percentage rate and feedstuff-egg ratio can also be significantly improved; Can also further Chinese medicine feed additive of the present invention and appropriate melatonin be used in combination, can improve equally the laying rate of laying hen, improve the egg laying performance such as draw egg size and feedstuff-egg ratio of laying hen simultaneously.
The specific embodiment
The invention provides a kind of Chinese medicine that improves laying rate of laying hen, its raw medicinal material comprises: Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, the Radix Astragali, Radix potentillae anserinae, Rhizoma Arundinis Donacis, Herba Canscorae, Cornu Cervi Pantotrichum, Flos Carthami, Oriental Blechnum Fern Rhizome, Herba Leonuri, Fructus Crataegi, Radix polygalae arillatae, Fructus Schisandrae Chinensis, Arillus Longan, Fructus Psoraleae, thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix Et Caulis Acanthopanacis Senticosi: pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix potentillae anserinae: sweet, bitter, cold.Return spleen, stomach warp.Fill blood; Strengthening the spleen and stomach; Promoting the production of body fluid to quench thirst.Main diarrhea due to hypofunction of the spleen; Anemia after being ill; Malnutrition; Edema; Rheumatic arthralgia.
Rhizoma Arundinis Donacis: hardship; Cold; Sweet.Clearing away heat-fire; The relieving restlessness of promoting the production of body fluid; Diuresis.Main calentura excessive thirst; Asthenia hectic fever due to YIN-deficiency; Spit blood; Pyretic stranguria; Dysuria; Acute toothache.
Herba Canscorae: micro-sweet, micro-hardship; Cool in nature.Return lung, spleen, stomach, Liver Channel.Heat-clearing and toxic substances removing; Vital energy regualting and blood circulation-promoting.Main cough due to lung-heat; Hepatitis; Leptospirosis; Chest pain; Stomachache; Traumatic injury; Venom.
Cornu Cervi Pantotrichum: sweet, salty, temperature.Return kidney, Liver Channel.Invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjusts punching to appoint, holder sore.For sexual impotence spermatorrhea, cold womb is infertile, weakness and emaciation, and Mental fatigue, fear of cold, vertigo and tinnitus deafness, spinal column cold type of pain, muscles and bones flaccidity is soft, bleeding not during menses, carbuncle of yin nature is not held back.
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Oriental Blechnum Fern Rhizome: hardship; Cool.Heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis; Anthelmintic.Main flu; Headache; Parotitis; Carbuncle; Traumatic injury; Epistaxis; Spit blood; Metrorrhagia; Leukorrhagia; Enterozoa.
Herba Leonuri: bitter, pungent, be slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Radix polygalae arillatae: sweet; Micro-hardship; Flat.The dehumidifying of eliminating the phlegm; Tonify deficiency spleen invigorating; Mind calming is invigorated blood circulation.Main cough with copious phlegm; Rheumatic arthralgia; Urine leaching pain; Edema; Foot gas; Hepatitis; Pulmonary tuberculosis; Puerperal asthenia; Inappetence; Infantile malnutrition; Insomnia and dreamful sleep; Menoxenia; Traumatic injury.
Fructus Schisandrae Chinensis: sour, sweet, temperature.Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Arillus Longan: sweet, temperature.GUIXIN, spleen channel.Invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.Warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Thorn fossilia dentis mastodi: acrid in the mouth; Micro-hardship; Sweet; Property is put down.Vital energy benefiting and the kidney invigorating; Expelling wind and removing dampness; Promoting blood circulation and stopping pain.The main deficiency of vital energy is weak; Impotence due to deficiency of the kidney; Gastric abscess; Quench one's thirst; Insomnia and dreamful sleep; Rheumatoid bone bi-syndrome; Weakness of the waist and knees; Traumatic injury; Fracture; Expand; Edema; Proctoptosis; Scabies.
Rhizoma Corydalis Decumbentis: bitter, micro-pungent, temperature.Return Liver Channel.Promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can be as follows: 30～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～30 parts of Fructus Lycii, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix potentillae anserinae, 5～10 parts of Rhizoma Arundinis Donaciss, 8～15 parts of Herba Canscoraes, 10～20 parts, Cornu Cervi Pantotrichum, 15～25 parts, Flos Carthami, 5～10 parts of Oriental Blechnum Fern Rhizomes, 20～30 parts of Herba Leonuris, 25～35 parts of Fructus Crataegis, 10～20 parts of Radix polygalae arillatae, 15～25 parts of Fructus Schisandrae Chinensis, 10～20 parts of Arillus Longans, 20～30 parts of Fructus Psoraleaes, 5～10 parts of 5～15 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can also be preferably as follows: 35～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 25～30 parts of Fructus Lycii, 15～20 parts of the Radixs Astragali, 10～15 parts of Radix potentillae anserinae, 5～8 parts of Rhizoma Arundinis Donaciss, 8～10 parts of Herba Canscoraes, 10～15 parts, Cornu Cervi Pantotrichum, 15～20 parts, Flos Carthami, 8～10 parts of Oriental Blechnum Fern Rhizomes, 25～30 parts of Herba Leonuris, 25～30 parts of Fructus Crataegis, 10～15 parts of Radix polygalae arillatae, 20～25 parts of Fructus Schisandrae Chinensis, 15～20 parts of Arillus Longans, 20～25 parts of Fructus Psoraleaes, 5～7 parts of 5～10 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine can be preferably as follows again: 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Lycii, 16 parts of the Radixs Astragali, 12 parts of Radix potentillae anserinae, 6 parts of Rhizoma Arundinis Donaciss, 9 parts of Herba Canscoraes, 13 parts, Cornu Cervi Pantotrichum, 18 parts, Flos Carthami, 9 parts of Oriental Blechnum Fern Rhizomes, 29 parts of Herba Leonuris, 28 parts of Fructus Crataegis, 10 parts of Radix polygalae arillatae, 23 parts of Fructus Schisandrae Chinensis, 17 parts of Arillus Longans, 22 parts of Fructus Psoraleaes, 7 parts of 8 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, the ratio of weight and number of the each raw medicinal material of described Chinese medicine also can be preferably as follows: 38 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Fructus Lycii, 18 parts of the Radixs Astragali, 14 parts of Radix potentillae anserinae, 7 parts of Rhizoma Arundinis Donaciss, 8 parts of Herba Canscoraes, 11 parts, Cornu Cervi Pantotrichum, 16 parts, Flos Carthami, 10 parts of Oriental Blechnum Fern Rhizomes, 25 parts of Herba Leonuris, 27 parts of Fructus Crataegis, 12 parts of Radix polygalae arillatae, 21 parts of Fructus Schisandrae Chinensis, 15 parts of Arillus Longans, 24 parts of Fructus Psoraleaes, 5 parts of 6 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
Wherein, in described Chinese medicine, can also further include the melatonin of 8～15mg/kg.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Wherein, described preparation method is further comprising the steps of:
The 4th step, the described powder that the 3rd step is obtained is mixed homogeneously with described melatonin.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby how application technology means solve technical problem in the present invention, reach technique effect and implement according to this.
Embodiment 1: powder one
Get Radix Et Caulis Acanthopanacis Senticosi 380g, Fructus Lycii 260g, Radix Astragali 180g, Radix potentillae anserinae 140g, Rhizoma Arundinis Donacis 70g, Herba Canscorae 80g, Cornu Cervi Pantotrichum 110g, Flos Carthami 160g, Oriental Blechnum Fern Rhizome 100g, Herba Leonuri 250g, Fructus Crataegi 270g, Radix polygalae arillatae 120g, Fructus Schisandrae Chinensis 210g, Arillus Longan 150g, Fructus Psoraleae 240g, thorn fossilia dentis mastodi 60g and Rhizoma Corydalis Decumbentis 50g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each above-mentioned Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4 times of mixture qualities be 90%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes, and sieves, and obtains 300 object micropowders;
The 3rd step adds the starch with respect to 3 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Embodiment 2: powder two
Get Radix Et Caulis Acanthopanacis Senticosi 350g, Fructus Lycii 290g, Radix Astragali 160g, Radix potentillae anserinae 120g, Rhizoma Arundinis Donacis 60g, Herba Canscorae 90g, Cornu Cervi Pantotrichum 130g, Flos Carthami 180g, Oriental Blechnum Fern Rhizome 90g, Herba Leonuri 290g, Fructus Crataegi 280g, Radix polygalae arillatae 100g, Fructus Schisandrae Chinensis 230g, Arillus Longan 170g, Fructus Psoraleae 220g, thorn fossilia dentis mastodi 80g and Rhizoma Corydalis Decumbentis 70g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 3 times of mixture qualities be 95%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes, and sieves, and obtains 400 object micropowders;
The 3rd step adds the starch with respect to 2 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
Toxicity test:
Acute toxicity testing: 70 of application mices, male and female half and half, body weight 21～29g, carries out acute toxicity testing.Mice is divided into two groups at random, be matched group and administration group, fasting 12 hours before experiment, Chinese powder medicine one prepared by embodiments of the invention 1 is dissolved in water, (concentration is 15.54g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 77.7 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage powder one LD50>77.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 155.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 2g crude drug/day/chicken, and the laying hen body weight of growing up is in 1.8KG, and average dosage is 1.111g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is take 25g) oral administration gavage Chinese medicine of the present invention is 140 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: a pair of mice of Chinese medicine embodiment 1 powder of the present invention is by 4.82,9.32 and 15 weeks (1.0ml/100g body weight of 17.42g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as the hair of Chinese medicine of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Culture experiment:
Laboratory animal: place of Linyi City suburb poultry specialist selects 2800 of good, the Luo Man laying hens that laying rate is approaching of body condition in 26 week age, is divided at random three groups, two experimental grouies (experimental group one and experimental group two) and a matched group.Experimental chicken is raised in cages, free choice feeding and drinking-water, conventional feeding and management.
Experimental technique: one: 950 of experimental group, in the normal feedstuff of feeding, add Chinese powder medicine one feed additive of the embodiment of the present invention 1 in 1.5% ratio, connect and feed 30 days.
Two: 950 of experimental grouies add Chinese powder medicine two feed additives of the embodiment of the present invention 2 in the normal feedstuff of feeding in 1.5% ratio, add melatonin in the ratio of 12mg/kg simultaneously, connect and feed 30 days.
Matched group: 900, the normal feedstuff of only feeding.
3 groups of other conditions are all identical.
Experimental period: since on February 10th, 2013, be divided into preliminary trial period and experimental period.Preliminary trial period is 10 days, and experimental period is 30 days.
Observe statistical indicator: observe the situation of searching for food of chicken every day, record egg production, weight, feed consumption rate, broken egg, soft egg, abnormal-shape egg quantity, dead chicken quantity etc., add up the indexs such as each group of feed intake, laying rate, egg size, rate of broken eggs, feedstuff-egg ratio.
Result:
1, preliminary trial period and experimental period (adding up once respectively for the 10th day, the 20th day and the 30th day) impact of Chinese medicine additive on laying rate, in table 1.
The impact (%) of table 1 Chinese medicine additive on laying rate
Known by table 1 content: by adding the combination of Chinese medicine feed additive of the present invention and Chinese medicine feed additive and melatonin, can to significantly improve the laying rate of laying hen.
2, preliminary trial period and the impact of experimental period Chinese medicine additive on average egg weight and feedstuff-egg ratio, in table 2.
The impact (%) of table 2 Chinese medicine additive on average egg weight and feedstuff-egg ratio
Known by table 2 content: by adding the combination of Chinese medicine feed additive of the present invention and Chinese medicine feed additive and melatonin, can to significantly improve the average egg weight of laying hen, reduce feedstuff-egg ratio.
3, preliminary trial period and experimental period Chinese herbal medicine are on yolk index and the percentile impact of egg yolk, in table 3.Each group of 20 pieces of random acquisition Fresh Egg respectively after preliminary trial period and experimental period finish, the broken shell of weighing, separates Ovum Gallus domesticus album, egg yolk is placed in flat on glass, measures egg yolk width, egg yolk height with micrometer.Press yolk index=egg yolk height (centimetre)/egg yolk width (centimetre) x100.Experiment with computing result shows, tests the increases more to some extent of each group of yolk index and matched group.
Table 3 Chinese medicine additive is on yolk index and the percentile impact of egg yolk
Known by table 3 content: by adding the combination of Chinese medicine feed additive of the present invention and Chinese medicine feed additive and melatonin, can to significantly improve yolk index and the egg yolk percentage rate of laying hen.
In sum, by adding the combination of Chinese medicine feed additive of the present invention and Chinese medicine feed additive and melatonin, experimental group one and experimental group two, with respect to matched group, can significantly improve the laying rate of laying hen, can also significantly improve average egg weight, yolk index and the egg yolk percentage rate of egg, reduce feedstuff-egg ratio; Simultaneously according to other statistical results of preliminary trial period and experimental period, known: the experimental group two that adds the experimental group one of Chinese medicine feed additive of the present invention and the combination of interpolation Chinese medicine feed additive of the present invention and melatonin, with respect to matched group, can also improve the feed intake of laying hen, egg production, reduces soft egg and the quantity of abnormal-shape egg and the quantity of broken egg.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Chinese medicine that improves laying rate of laying hen, is characterized in that, the each raw medicinal material of described Chinese medicine comprises: Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, the Radix Astragali, Radix potentillae anserinae, Rhizoma Arundinis Donacis, Herba Canscorae, Cornu Cervi Pantotrichum, Flos Carthami, Oriental Blechnum Fern Rhizome, Herba Leonuri, Fructus Crataegi, Radix polygalae arillatae, Fructus Schisandrae Chinensis, Arillus Longan, Fructus Psoraleae, thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of the each raw medicinal material of described Chinese medicine is as follows: 30～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～30 parts of Fructus Lycii, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix potentillae anserinae, 5～10 parts of Rhizoma Arundinis Donaciss, 8～15 parts of Herba Canscoraes, 10～20 parts, Cornu Cervi Pantotrichum, 15～25 parts, Flos Carthami, 5～10 parts of Oriental Blechnum Fern Rhizomes, 20～30 parts of Herba Leonuris, 25～35 parts of Fructus Crataegis, 10～20 parts of Radix polygalae arillatae, 15～25 parts of Fructus Schisandrae Chinensis, 10～20 parts of Arillus Longans, 20～30 parts of Fructus Psoraleaes, 5～10 parts of 5～15 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of the each raw medicinal material of described Chinese medicine is as follows: 35～40 parts of Radix Et Caulis Acanthopanacis Senticosis, 25～30 parts of Fructus Lycii, 15～20 parts of the Radixs Astragali, 10～15 parts of Radix potentillae anserinae, 5～8 parts of Rhizoma Arundinis Donaciss, 8～10 parts of Herba Canscoraes, 10～15 parts, Cornu Cervi Pantotrichum, 15～20 parts, Flos Carthami, 8～10 parts of Oriental Blechnum Fern Rhizomes, 25～30 parts of Herba Leonuris, 25～30 parts of Fructus Crataegis, 10～15 parts of Radix polygalae arillatae, 20～25 parts of Fructus Schisandrae Chinensis, 15～20 parts of Arillus Longans, 20～25 parts of Fructus Psoraleaes, 5～7 parts of 5～10 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of the each raw medicinal material of described Chinese medicine is as follows: 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Lycii, 16 parts of the Radixs Astragali, 12 parts of Radix potentillae anserinae, 6 parts of Rhizoma Arundinis Donaciss, 9 parts of Herba Canscoraes, 13 parts, Cornu Cervi Pantotrichum, 18 parts, Flos Carthami, 9 parts of Oriental Blechnum Fern Rhizomes, 29 parts of Herba Leonuris, 28 parts of Fructus Crataegis, 10 parts of Radix polygalae arillatae, 23 parts of Fructus Schisandrae Chinensis, 17 parts of Arillus Longans, 22 parts of Fructus Psoraleaes, 7 parts of 8 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of the each raw medicinal material of described Chinese medicine is as follows: 38 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Fructus Lycii, 18 parts of the Radixs Astragali, 14 parts of Radix potentillae anserinae, 7 parts of Rhizoma Arundinis Donaciss, 8 parts of Herba Canscoraes, 11 parts, Cornu Cervi Pantotrichum, 16 parts, Flos Carthami, 10 parts of Oriental Blechnum Fern Rhizomes, 25 parts of Herba Leonuris, 27 parts of Fructus Crataegis, 12 parts of Radix polygalae arillatae, 21 parts of Fructus Schisandrae Chinensis, 15 parts of Arillus Longans, 24 parts of Fructus Psoraleaes, 5 parts of 6 parts of thorn fossilia dentis mastodi and Rhizoma Corydalis Decumbentiss.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
7. the Chinese medicine as described in claim 1 to 6, is characterized in that, also includes the melatonin of 8～15mg/kg in described Chinese medicine.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 2～4 times of mixture qualities be 85～95%, and reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The ethanol that it is 85～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 1～2 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;
The 3rd step adds the starch with respect to 2～4 times of its quality in the micropowders that second step is obtained, and mixes, and obtains powder.
9. the preparation method of Chinese medicine as claimed in claim 8, is characterized in that, described preparation method is further comprising the steps of:
The 4th step, the described powder that the 3rd step is obtained is mixed homogeneously with described melatonin.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105746846A (en) * | 2014-12-16 | 2016-07-13 | 北京大北农动物保健科技有限责任公司 | Dodder seed-motherwort-pot marigold pharmaceutical composition, and premix, concentrate feed, batch mixture and application thereof |
| CN106036027A (en) * | 2016-07-07 | 2016-10-26 | 山东新希望六和集团有限公司 | Feed additive for improving productivity of layers in high-temperature seasons and preparation method thereof |
| CN114052143A (en) * | 2021-12-02 | 2022-02-18 | 河南牧业经济学院 | Compound preparation for maintaining egg laying peak of laying hens in final egg laying period and application method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911078A (en) * | 2006-08-12 | 2007-02-14 | 尚秀园 | Recipe of herb medicine additive of forage for improving egg prodn, and egg quality |
| CN101954023A (en) * | 2010-10-29 | 2011-01-26 | 张兴龙 | Traditional Chinese medicinal composition for improving laying rate of poultry and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911078A (en) * | 2006-08-12 | 2007-02-14 | 尚秀园 | Recipe of herb medicine additive of forage for improving egg prodn, and egg quality |
| CN101954023A (en) * | 2010-10-29 | 2011-01-26 | 张兴龙 | Traditional Chinese medicinal composition for improving laying rate of poultry and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105746846A (en) * | 2014-12-16 | 2016-07-13 | 北京大北农动物保健科技有限责任公司 | Dodder seed-motherwort-pot marigold pharmaceutical composition, and premix, concentrate feed, batch mixture and application thereof |
| CN106036027A (en) * | 2016-07-07 | 2016-10-26 | 山东新希望六和集团有限公司 | Feed additive for improving productivity of layers in high-temperature seasons and preparation method thereof |
| CN114052143A (en) * | 2021-12-02 | 2022-02-18 | 河南牧业经济学院 | Compound preparation for maintaining egg laying peak of laying hens in final egg laying period and application method |
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