CN104162090A - Medicine composition and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine composition. The medicine composition is prepared from radix rehmanniae, prepared rhizome of rehmanniae, fructus amomi, astragalus complanatus, herba artemisiae anomalae, milkwort root, rhizoma pinelliae, glossy privet fruit, kudzuvine root, fructus corni, mulberries, rhizoma polygonati, amur corktree bark, radix polygoni multiflori preparata, sharpleaf galangal fruit, pawpaws, raw jujube kernels, ripe jujube kernels, dipsacus root, cibot rhizome, cortex eucommiae, barbary wolfberry fruit, dried longan pulp, herba epimedii, curculigo orchioides, cynomorium songaricum, red dates, deer-horn glue and adjuvant materials. The medicine composition has the functions of tonifying the kidneys to promote primordial qi and tranquilizing the mind by nourishing the heart, is suitable for male patients who are in sub-health statuses, have low immunities and are nursed back to health at the earlier stage of biological immunotherapy, and can improve renal dysfunction of patients undergoing chemoradiotherapy. The prepared medicines have obvious curative effects and do not have toxic or side effects.

Description

A kind of pharmaceutical composition and preparation method thereof

Invention field:

The present invention relates to a kind of pharmaceutical composition (having another name called imperial cream) and preparation method thereof, belong to the field of medicine technology.

Technical background:

Disease (Cancer), also claims malignant tumor (Malignant neoplasm), serves as reasons and controls the not normal and disease that causes of growth and proliferation of cell mechanism.Cancerous cell except grow out of control, arround also can local invading, normal structure is even transferred to other parts of health via body-internal-circulation system or lymphsystem.In order to control the injury of cancer to health, often adopt chemicotherapy to treat cancer.The i.e. chemistry birth of chemicotherapy treatment is that the medicine that is able to disease due to pathogenic microorganism, parasite, malignant tumor is promoted treatment.Chemotherapy also refers to start drug application treatment cancer, and these special medicines can killing off tumor cells, is sometimes referred to as cell toxicity medicament.Radiotherapy is exactly radiotherapy, refers to eliminate focus with ray, and radiotherapy is as an important means for the treatment of malignant tumor.Some chemotherapeutics are to take in the mode of tablet, other are through intramuscular injection or hypodermic, also has injection (intrathecal injection) in spinal cavity, more usually intravenous injection intravenous injection can complete in several minutes in diagnosis and treatment, also can be placed on interior the instillation a few hours of liquid of large volume, multiple medications internal medicine section office application simultaneously sometimes.The side effect of chemicotherapy allows many patients misery very, and some people does not often take even a drop of water, cannot normal diet.In addition important organ is had a strong impact on, the especially damage to renal function, serious even causes death.In human body, kidney has important effect, and as patient's impaired renal function, sb.'s illness took a turn for the worse can to increase the weight of patient's whole body.So it is particularly important to improve chemicotherapy patient's renal function.

In addition, modern civilization has been brought social progress, the improving constantly of people's quality of life, but the puzzlement of bringing thus can not be ignored.Most people is bearing huge pressure, feels exhausted, and energy exhaustion, usually there will be the hepatic and renal YIN deficiency such as insomnia, loss of appetite, weak, irritated neurasthenia, brain deficient syndrome shape.Particularly even young man of middle-aged male, they are bearing huge life, emotion, operating pressure, for a long time in high pressure conditions, tire out and the fashion term having hurried into menfolk, usually in sub-health states such as vexed, insomnia, nervous, physical weakness, these states are injuring the healthy and happy of man virtually, and man also pays a high price for when results are had a successful career fruit.They are in the time running into the diseases such as mind uneasiness such as nervous cardiopalmus, insomnia and dreamful sleep, doctor trained in Western medicine is treated mainly with tranquilizer and sleeping pill etc., but the untoward reaction of these medicines is often larger, and may produce dependence effect, and the traditional Chinese medical science be particular about be preventive treatment of disease, Chinese medicine has good prophylactic effect, for the treatment of this type of disease, Chinese medicine thinks that male's kidney qi is weak gradually, and namely health is old and feeble gradually, " people's gassiness and giving birth to, essence to the greatest extent and dead ".Health care's real meaning is to reinforce the kidney, and negative and positive are held concurrently and mended, and tonify deficiency is weak, bone and muscle strengthening, kidney tonifying the moon, kidney-Yang invigorating, promoting blood circulation are main.Often can adopt the less medicine of successful and untoward reaction.Male health preserving, importantly the kidney invigorating, vital base and primordial QI consolidating.So invent a kind of renal function that improves chemicotherapy patient, there is the nourish heart medicine of effect of the kidney invigorating and have great importance.

Summary of the invention:

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition (imperial cream) and preparation method thereof.Described medicine has effect of tonifying kidney, tranquilizing by nourishing the heart, is applicable to sub-health state, hypoimmunity and carries out the male patient that biological immune treatment is taken good care of in earlier stage, can also improve chemicotherapy patient's renal dysfunction.

For solving above technical problem, the present invention realizes by the following technical solutions:

A kind of pharmaceutical composition, calculate according to composition by weight, by Radix Rehmanniae 20-100 part, Radix Rehmanniae Preparata 20-100 part, Fructus Amomi 5-50 part, Semen Astragali Complanati 20-100 part, Herba Artemisiae Anomalae 10-60 part, Radix Polygalae 5-50 part, Rhizoma Pinelliae Preparatum 5-50 part, Fructus Ligustri Lucidi 10-60 part, Radix Puerariae 10-60 part, Fructus Corni 20-100 part, Fructus Mori 20-100 part, Rhizoma Polygonati 20-100 part, Cortex Phellodendri 10-60 part, Radix Polygoni Multiflori Preparata 20-100 part, Fructus Alpiniae Oxyphyllae 5-50 part, Fructus Chaenomelis 5-50 part, raw Semen Ziziphi Spinosae 10-600 part, ripe Semen Ziziphi Spinosae 10-60 part, Radix Dipsaci 20-100 part, Rhizoma Cibotii 20-100 part, Cortex Eucommiae 10-60 part, Fructus Lycii 10-60 part, Arillus Longan 10-60 part, Herba Epimedii 10-80 part, Rhizoma Curculiginis 10-80 part, Herba Cynomorii 10-60 part, Fructus Jujubae 10-60 part, Colla cornus cervi 10-60 part and adjuvant are prepared from.

Specifically, described pharmaceutical composition calculates according to composition by weight, by 50 parts, the Radix Rehmanniae, 50 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Amomis, 50 parts of Semen Astragali Complanatis, 30 parts of Herba Artemisiae Anomalaes, 10 parts of Radix Polygalaes, 10 parts of Rhizoma Pinelliae Preparatum, 30 parts of Fructus Ligustri Lucidi, 30 parts of Radix Puerariaes, 50 parts of Fructus Cornis, 50 parts of Fructus Mori, 50 parts of Rhizoma Polygonatis, 30 parts of Cortex Phellodendris, 50 parts of Radix Polygoni Multiflori Preparata, 10 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Fructus Chaenomeliss, 30 parts of raw Semen Ziziphi Spinosaes, 30 parts of ripe Semen Ziziphi Spinosaes, 50 parts of Radix Dipsaci, 50 parts of Rhizoma Cibotii, 30 parts of the Cortexs Eucommiae, 30 parts of Fructus Lyciis, 30 parts of Arillus Longans, 40 parts of Herba Epimedii, 40 parts of Rhizoma Curculiginises, 30 parts of Herba Cynomoriis, 30 parts of Fructus Jujubaes, 30 parts of Colla cornus cervis and adjuvant are prepared from.

The preparation method of aforementioned pharmaceutical composition is: proportionally all medical materials in the side of taking, and combine with acceptable pharmaceutic adjuvant in medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.

Specifically, the preparation method of aforementioned pharmaceutical composition is: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, filtrate is condensed into extractum, combine with acceptable pharmaceutic adjuvant in medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.

Described pharmaceutical preparation is soft extract, hard capsule, ointment, tablet, granule, pill, oral liquid, syrup, powder, sublimed preparation, suspensoid, solution, injection, freeze-dried powder, bulk capacity injection, suppository, plaster, cream, spray or patch.

Described pharmaceutical preparation is soft extract, capsule, granule or oral liquid.

Described soft extract is prepared like this: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, separately get the crystal sugar of the amount of making 20%, add the boiled water of measuring with doubly, be heated to whole dissolvings, slowly add in above-mentioned extractum, stir, continue to receive cream with slow fire heating, wait to get a little energy horizontal drawing filamentation, or drip on paper not when water breakthrough mark, to obtain final product.

Described capsule is prepared like this: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three decocting liquids merge, and mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20,75 DEG C of following conventional dryings become dry extract, be ground into fine powder, add the dextrin mix homogeneously of the amount of making 10%, with 75% alcohol granulation, dry, granulate, loads capsule, to obtain final product.

Described granule is prepared like this: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, extractum is dry in 60 DEG C, and be ground into fine powder, add the mixed accessories of the amount of making 25% to mix, mixed accessories is mixed with the ratio of 1:1 by microcrystalline Cellulose and corn starch, with 90% ethanol be wetting agent granule processed, dry in 60 DEG C after granulation, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain.

Described oral liquid is prepared like this: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, and mixes, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.10-1.15, the sucrose of separately getting the amount of making 30% adds in the water boiling to be made to be uniformly dissolved, filter, make simple syrup; Simple syrup is added in extractum for subsequent use, add the sodium benzoate of the amount of making 0.2%, boil dissolving, add pure water and be settled to full dose, stir evenly, filter, embedding, obtains oral liquid.

Pharmaceutical composition of the present invention is in the time making medicament, and the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable adjuvant.Pharmaceutically acceptable adjuvant can be the 0.1-99.9% of total formulation weight amount by weight.

Medicine of the present invention is prepared from by the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Amomi, Semen Astragali Complanati, Herba Artemisiae Anomalae, Radix Polygalae, Rhizoma Pinelliae Preparatum, Fructus Ligustri Lucidi, Radix Puerariae, Fructus Corni, Fructus Mori, Rhizoma Polygonati, Cortex Phellodendri, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Fructus Chaenomelis, raw Semen Ziziphi Spinosae, ripe Semen Ziziphi Spinosae, Radix Dipsaci, Rhizoma Cibotii, the Cortex Eucommiae, Fructus Lycii, Arillus Longan, Herba Epimedii, Rhizoma Curculiginis, Herba Cynomorii, Fructus Jujubae, Colla cornus cervi and adjuvant.Wherein, the Radix Rehmanniae has nourishing YIN and clearing away heat; The effect that removing heat from blood is enriched blood; Main calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease is sent out speckle; Haematemesis due to heat in blood; Metrorrhagia; Hematuria; Have blood in stool; Blood deficiency and yellow complexion; Dizzy cardiopalmus; Insufficiency of blood amenorrhea.Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), have another name called Radix Rehmanniae Preparata or throw oneself on the ground, concocting and form through processing, is a kind of first-class Chinese crude drug, has the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst.Fructus Amomi is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA; There is removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy; Fructus Amomi Main Function, in stomach, kidney and the spleen of human body, can whet the appetite in removing dampness, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive; For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Semen Astragali Complanati is the dry fruit of leguminous plant astragatus complanatus, sweet, warm, returns liver, kidney channel, has reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination, and effect of nourishing the liver to improve visual acuity, for lumbago due to renal deficiency, seminal emission premature ejaculation, enuresis frequent micturition, the inferior card of nebulousurine band.Herba Artemisiae Anomalae is the wounded in the battle herb of feverfew artemisia anomalas, has dissipating blood stasis to promote menstruationg, hemostasia and detumescence, effect of promoting digestion and removing stagnation.Radix Polygalae is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L., bitter, pungent, temperature, and GUIXIN, kidney, lung meridian, the Fructus Alpiniae Oxyphyllae of calming the nerves, restoring normal coordination between the heart and kidney, eliminates the phlegm, detumescence; The insomnia and dreamful sleep, forgetful palpitation with fear, the staring spells that cause for disarmony between the heart and kidney, expectoration is not well, sore swollen toxin, breast swell and pain.Rhizoma Pinelliae Preparatum is the dry tuber of aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) Breit., and this product is its processed product, pungent, warm; Poisonous; Return spleen, stomach, lung meridian; There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass, for damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; External treatment carbuncle sucutaneous nodule.Fructus Ligustri Lucidi is the dry mature fruit of Rhinocerotidae plant Fructus Ligustri Lucidi; There is nourishing the liver and kidney, effect of improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi, practises and claims Herba Gelsemii Elegantis, sweet, pungent, cool; Return spleen, stomach, lung meridian; There is expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, deinebriating effect, for fever caused by exogenous pathogens headache, the cards such as stiff nape and back.Fructus Corni is the skin of the mature fruit of Rhamnaceae machaka or dungarunga plant jujube tree; Sour in the mouth slightly warm in nature, enters liver, kidney channel; Have invigorating the liver and kidney, arresting seminal emission gas, Gu the effect of collapse; Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Fructus Mori are the mature fruit of Moraceae deciduous tree mulberry, there is the effects such as the body immunity, the YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, intestine moistening of raising be dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the xerostomia of quenching one's thirst, constipation with dry stool; In mulberry fruit, contain abundant glucose, sucrose, carotene, vitamin, malic acid, tartaric acid, the abundant nutritions such as phosphorus matter, and contain abundant activated protein, and often eat and can significantly improve body immunity, there is effect of slow down aging, youthful looks retaining and skin caring.Rhizoma Polygonati has another name called Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticus ginseng; Three kinds of point RHIZOMA POLYGONATI ZINGIBERIFORME, polygonatum sibiricum Redoute and large Rhizoma Polygonatis; For the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati, Rhizoma Polygonati or Polygonatum cyrtonema Hua; There is nourishing YIN and moistening the lung; Invigorating the spleen and replenishing QI, effect of Zishen fill fine; Cure mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, lack of appetite xerostomia, quench one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order are dark, empty thin, the wind favus disease etc. of winning of early whitening of beard and hair, body; Pharmacological research confirms, Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, and blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.Cortex Phellodendri is the dry bark of rutaceae wampee Phellodendron chinense Schneid., and hardship is cold, returns kidney, urinary bladder channel, has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.Radix Polygoni Multiflori Preparata is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., and this product is its processed product, Radix Polygoni Multiflori Preparata invigorating the liver and kidney, benefiting essence-blood, black beard and hair, strengthening bone and muscle.Fructus Alpiniae Oxyphyllae Fructus Alpiniae Oxyphyllae is the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae Alpinia oxyphylla Miq.; Warming the kidney controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrhaly takes the photograph saliva; For enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine, spleen-cold syndrome is had loose bowels, cold type of pain in abdomen, mouthful many salivas.Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai.Acid, temperature.Return liver, spleen channel; Relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness; For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, heat-damp in summer is vomited and diarrhoea, convulsion spasm and pain, beriberi edema.Semen Ziziphi Spinosae has another name called Semen Ziziphi Spinosae, is the ripe red tender fruit of gathering autumn, removes sarcocarp, dries, and grinds broken Semen Jujubae, takes out seed, raw with or fry and use.Used time smashes; The Semen Ziziphi Spinosae of making a living of raw use; Fry the ripe Semen Ziziphi Spinosae that is of use; Sweet in the mouth, acid, property is flat; Can nourish conscience, calm the nerves, effect of arresting sweating; Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Radix Dipsaci is the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asper Wall.ex Henry, and bitter, pungent, tepor, returns liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia; For deficiency of the liver and kindey, the diseases such as soreness of the waist and knees.Rhizoma Cibotii is the dry rhizome of Dicksoniaceae plant Rhizoma Cibotii Cibotium barometz (L.) J.Sm., bitter, sweet, temperature; Return liver, kidney channel, wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint; For rheumatic arthralgia, soreness of the waist and knees, the diseases such as weakness of the lower extremities.The Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv., sweet, temperature.Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive; For deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones is unable, have a dizzy spell, and blood leaking in gestation, the diseases such as frequent fetal movement.Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L., sweet, flat; Return liver, kidney channel; There is nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight; For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, the disease such as blurred vision is not clear.Arillus Longan sweet in the mouth warm in nature, heart-spleen boosting, fills blood; Have and well have nourishing tonification, fill blood, effect of Fructus Alpiniae Oxyphyllae mind calming, tranquilizing the mind, can be used for insomnia due to the insufficiency of the spleen damage of the heart, insufficiency of vital energy and blood, forgetful, palpitation with fear, the disease such as dizzy.Herba Epimedii is named again that Herba Epimedii, Herba Epimedii, celestial spirit are adjoined, Herba Epimedii, abandon cane grass, thousand liang of gold, dry chicken muscle, Rhizoma Coptidis ancestral, Epimedium etc., have effect of kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscle key bone, treatment impotence and seminal emission, cold caused by deficiency are sterile, frequent micturition is lost Chu, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless etc.Rhizoma Curculiginis is the rhizome of Bulbus Allii section plant Rhizoma Curculiginis, has the effect of reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and promoting the circulation of blood detumescence, is mainly used in the diseases such as insufficiency of kidney-YANG, impotence and seminal emission, chronic consumptive disease internal injury and bones and muscles pain.Herba Cynomorii is the fleshy stem of Cynomoriaceae plant Herba Cynomorii, has effect of kidney invigorating and YANG supporting, beneficial intestinal relieving constipation, call trivial sun, Herba Cynomorii, rust iron staff, ball top, yellow bone wolf, Songaria Cynomorium Herb, sheep lock do not draw; Control impotence due to deficiency of the kidney, seminal emission premature ejaculation, flaccidity and weakness of the lower limbs, empty people's constipation.Fructus Jujubae is again Fructus Jujubae, has nourishing spleen and stomach, invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, Glycerin, the effect of Fructus Jujubae: energy beauty and skin care, replenishing QI to invigorate the spleen, the biochemical circulation of promotion QI and blood and defying age; Fructus Jujubae sweet in the mouth warm in nature, contain protein, fat, sugar, calcium, phosphorus, ferrum, magnesium and abundant vitamin A, vitamin C, vitamin B1. vitamin B2, contain in addition carotene etc., nutrition is very abundant, among the peoplely there is saying of " eat Fructus Jujubae, bearing one's age well all one's life everyday ".Fructus Jujubae is not only the fruit that people like, is also nourishing spleen and stomach, nourishing blood to tranquillize the mind, the good medicine that promotes health and cures diseases simply.Colla cornus cervi is that Cornu Cervi is endured through decocting, the concentrated solid gum of making., there is temperature compensation Liver and kidney, beneficial intensive culture blood effect, for blood deficiency dizziness, the acid of waist knee joint is cold, and asthenia is become thin.

Man is with as congenital, and essence is hidden in kidney, and kidney essense is the base substance that forms human body and the activity that sustains life.The main growth promoter of kidney essense, main reproduction, raw marrow, fill brain, change hemopoietic liquid (essence and blood is changed mutually).According to the theory of " preventive treatment of disease ", man's tonifying kidney, tranquilizing by nourishing the heart are that first business is anxious.Therefore this cream side selects the in love product the kidney invigorating of Colla cornus cervi flesh and blood to fill marrow, tonifying vital QI is monarch; With raw Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, the Cortex Eucommiae, Fructus Corni, Fructus Ligustri Lucidi tonifying kidney-yin be minister, residence has the kind YANG invigorating person must be in treating YANG within YIN, positive that cloudy raw fountainhead is inexhaustible; Assistant is with Herba Epimedii, Rhizoma Curculiginis, Fructus Lycii, Herba Cynomorii, Fructus Alpiniae Oxyphyllae, Semen Astragali Complanati, Radix Dipsaci, Rhizoma Cibotii, Fructus Chaenomelis tonification Yuanyang, and residence has the justice of Yin grows while yang is generating, know well close kind nourishing YIN person must be in treating YIN within YANG, cloudy get Yang Sheng is biochemical infinite; Assistant is with Fructus Mori, Rhizoma Polygonati, the cloudy blood of Fructus Jujubae tonification; Assistant is with Cortex Phellodendri, Radix Polygalae, raw ripe Semen Ziziphi Spinosae, Rhizoma Pinelliae Preparata, Arillus Longan the mind calming and mentality promoting, restoring normal coordination between the heart and kidney; Assistant, with Herba Artemisiae Anomalae, Radix Puerariae blood circulation promoting and blood stasis dispelling, yang invigorating Tianjin, makes the medicine of kidney-replenishing, tonifying kidney-yin, tonify without causing stagnation; With Fructus Amomi for making, agitate QI of the spleen and stomach, make that the current whole body of the above-mentioned efficacy of a drug is upper and lower, extremity bones of the body collectively, face nine orifices, with crystal sugar person also have with middle emergency, sweet temperature compensation in merit, all medicines are with using, play altogether the effect of tonifying kidney, tranquilizing by nourishing the heart, such as congenital defect, the day after tomorrow lose foster and see the card that Costumes is thin, all can use it.

In prescription, contained medical material, is mostly water soluble ingredient, therefore considers the needs of large production, from the angle of clinical safety application, considers to adopt water extraction process to obtain extracting solution.Water is as extracting solution, not only economical and practical, and extraction effect ideal.Amount of water extraction time and number of times all can affect the extraction rate of effective ingredient, if amount of water deficiency likely causes solvent can not soak prescription medical material, and if decoct time inadequate, medicinal ingredient could not fully extract, and affects the leaching rate of medical material.Decocting time is long, and excess Temperature can cause the decomposition of effective ingredient.Reduce on the contrary the extraction ratio of medical material.Medical material can be dissolved out effective ingredient substantially through 2-3 decoction, but extraction process by water is subject to the impact of a lot of conditions to a certain extent.As amount of water, decoction number of times, decocting time etc.For this reason, we adopt orthogonal experimental design method, filter out best extraction process condition.

The present invention has carried out a large amount of experimentatioies, is below the result of experimentation of the present invention:

Experimental example 1: technological experiment research:

1. orthogonal test factor level arranges

Taking amount of water (A), extraction time (B), extraction time (C) as investigating index.Factor level is in table 1.

Table 1 factor level table

2. orthogonal design

One of principal agent in the Rhizoma Cibotii side of being, therefore select its main effective ingredient protocatechuic acid and protocatechualdehyde work and dry cream yield as aggregative indicator, according to the arrangement of appeal factor level, adopts L ₉(3 ³) table arrangement orthogonal test, preferably best extraction process, in table 2.

Table 2 Orthogonal Experiment and Design

Note: taking yield of extract weight coefficient as 65, protocatechuic acid and protocatechualdehyde total content weight coefficient are 35, obtain comprehensive grading.

3. protocatechuic acid and protocatechualdehyde assay: according to " Chinese Pharmacopoeia " annex VI D high effective liquid chromatography for measuring

3.1 chromatographic conditions: taking octadecylsilane chemically bonded silica as filler; Taking methanol-0.1% phosphate aqueous solution (10:90) as mobile phase; Volume flow is 1.0mL/min; Detection wavelength is 258nm; 35 DEG C of column temperatures.

The preparation of 3.2 reference substance solution

Precision takes protocatechuic acid and protocatechualdehyde reference substance is appropriate respectively, with 50% dissolve with methanol make respectively 0.282, the solution of 0.0952mg/mL.

The preparation of 3.3 need testing solutions

Get dry extract 1g, accurately weighed, to put in tool plug conical flask, precision adds 50% methanol 10mL, weighed quality, ultrasonic 60min, lets cool, more weighed quality, supplies quality with 50% methanol, shakes up, and filters, and gets subsequent filtrate centrifugal and get final product.

3.4 algoscopy

Accurate reference substance solution and the each 10 μ L of need testing solution of drawing respectively, injection liquid chromatography, measures, and to obtain final product.

The mensuration of 4 dry cream yield

Press L ₉(3 ⁴) show to extract the accurate equivalent concentrated solution 25mL that draws respectively.Be placed in the evaporating dish (W that is dried to constant weight ₁), water bath method, dry 3h, moves in exsiccator at 105 DEG C, cooling 30min, rapidly accurately weighed its quality (W ₂), calculate as follows yield of extract, orthogonal experiments is in table 2.

5 results

Analyze conclusion: being divided into index with general comment, is R by table 3 extreme difference size _c>R _b>R _a, i.e. extraction time > amount of water > extraction time, determine extraction process A through intuitive analysis ₂b ₁c ₃, 8 times of water gagings extract 3 times, each 1 hour.

Experimental example 2: pharmacodynamic study

One, the sedation to mice

1. experimental technique

1.1 laboratory animals: Kunming kind white mice 18-22g, male and female half and half.

1.2 medicines: (method according to embodiment 1 is made unguentum to plaster of the present invention, but do not comprise the step that adds crystal sugar), adding distil water is diluted to experiment desired concn: high dose: 75% (crude drug in whole 0.75g/mL), low dosage: 40% (crude drug in whole 0.4g/mL); Stable: Guangdong Shi Qi pharmaceutical factory produces, specification: 2.5mg/ sheet, lot number: 000948.Pentobarbital sodium: Solution on Chemical Reagents in Shanghai purchasing and supply station chemical reagent work produces, lot number: 800603.Normal saline, Tri-Lion Pharmaceutical Co., Ltd., Harbin, lot number 101009A6.

2. 50 of mices are got in the impact on mice sedation (trembling cage transducer method), and male and female half and half, are divided into 5 groups at random, fasting 8h before experiment.Install and tremble cage assembly, get 1 mice and put into cage, allow it adapt to start to record its normal activity curve after 3min.Trace after one section of curve mice is taken out, by table 1 administration of dividing into groups.After 30rain, put back to cage, activity curve after recording medicine, the movable waveform of animal before and after comparative analysis medication, relatively, the results are shown in Table 3 between organizing with t inspection.

The impact of table 3 on spontaneous activity in mice

Compared with normal saline group, * P<0.05, * * P<0.01

From upper table result, each group of this patent invention soft extract and the stable effect with obvious inhibition spontaneous activity in mice, and each group have significant difference (P<0.05) compared with blank group.And from low dosage to high dose, there is the effect increasing gradually.The soft extract that is this patent invention has remarkable sedation.

3. on the fall asleep impact of number of mice

Get 50 of mices, male and female half and half, are divided into 5 groups at random.Fasting 8h before experiment, by table 2 gastric infusion respectively, after 30min, lumbar injection pentobarbital sodium 30mg/kg, reach more than 1min mice for the index of falling asleep with righting reflex loss, that observes each group in 15min enters glirid number, between organizing, compares with Fisher exact propability.The results are shown in Table 4.

Table 4 is on the fall asleep impact of number of mice

Note: compared with normal saline group, * P<0.05, * * P<0.01

Result shows: compared with normal saline group, patent soft extract of the present invention can make to increase into glirid number, illustrates that this patent invention soft extract has synergism to pentobarbital sodium.And have the effect increasing gradually from low dosage to high dose, but statistical procedures no significant difference.

Two, the impact on the rat of suffering from a deficiency of the kidney

1. testing animal SD is rat.

2. medicine: (method according to embodiment 1 is made unguentum to plaster of the present invention, but do not comprise the step that adds crystal sugar), adding distil water is diluted to experiment desired concn: high dose: 75% (crude drug in whole 0.75g/mL), low dosage: 40% (crude drug in whole 0.4g/mL); Shengwujian Oral Liquid, Guangdong TAIYANGSHEN group product, lot number 93l114A; Testosterone propionate injection, Mingxing Pharmaceutical Factory, Guangzhou is produced, lot number 911122.

3. 40 of experimental technique male rats, animal is defended under barbital sodium (45mg/kg) anesthesia 0.6%, carries out bilateral orchidectomy, postoperative intramuscular injection penicillin 20,000 U/kg, 2d altogether, with infection, after castration operation 3d, 40 castrated rats are divided into 4 groups at random.1st, 2 groups of difference gavage this patent invention plaster 15g/kg, 10g/kg.The 3rd group gives equal-volume distilled water as castration model control group, and positive drug group gives androlin.Every day 1 time, continuously 14d, simultaneously using 10 not castrated rats as normal control.15d after administration, takes rapidly preputial glands by sacrifice of animal, seminal fluid capsule, and prostate and levator ani weight, calculate organ index.The results are shown in Table 5.

The impact of table 5 on castrated rats preputial glands, seminal fluid capsule, weight of prostate and organ index

Result shows, the each weight of reproductive organs section organ index of animal (castration model group) of suffering from a deficiency of the kidney is all starkly lower than intact animal, and soft extract of the present invention is respectively organized weight of reproductive organs and organ index and castration model group no significant difference (P>0.05), but compare P<0.0l with androlin group.

Three, on chemotherapy Mouse Kidney biochemical indicator and pathological impact

1. materials and methods

1.1 laboratory animal

Male Kunming strain mice, in 5 week age, body weight (19.94 ± 0.52) g, is provided by Guiyang Medical College animal feeding center.The male S180 tumor-bearing mice of Kunming kind, in 5 week age, body weight (20.24 ± 0.41) g, is provided by Guiyang Medical College animal feeding center.

1.2 Experimental agents

Plaster of the present invention (method according to embodiment 1 is made unguentum, but does not comprise the step that adds crystal sugar), cisplatin: 10mg/ bottle (Qilu Pharmaceutical Factory's production).

1.3 experimental design

Before the experiment of all experiment mices, all adopt table of random number random packet, to guarantee to eliminate because of experimental bias due to animal individual difference.Before the experiment of S180 tumor-bearing mice, all inoculate equivalent S180 tumor cell (10 in health same area (right oxter) simultaneously ⁶/ only), after inoculation, 24h starts administration observation, and 7-10d is as a course for the treatment of.

1.4 experimental technique

1.4.1 observe the impact of various dose cisplatin on mouse kidney pathology:

40 Kunming mouses are divided into 5 groups at random, 8 every group.Start in experiment the 1st day respectively with normal saline 0.2ml (blank), cisplatin 3,7,11,15mg/kg ^-1lumbar injection.Wherein cisplatin 15mg/kg ^-1group has respectively 5 mices in experiment the the the 78th, 90,98,105,122h death.After verified death, dissect and get kidney immediately, and fix taking volume fraction as 20% formalin.Within the 8th day, by all de-cervical vertebra execution of survival mice, kidney is got in dissection immediately, and 20% formalin is fixed.Altogether 40 parts of kidney specimen are made pathologic finding.

1.4.2 the serology on Mouse Kidney infringement and the impact of pathology index:

Get 80 mices and be divided at random 4 groups.Be respectively normal saline (blank) group, alone cisplatin group, cisplatin and add unguentum 10 of the present invention, 15g/kg ^-1group.Blank group gives oral 2ml normal saline, totally 7 days every every day; Alone cisplatin group gives cisplatin 7mg/kg on the 1st day ^-1lumbar injection 1 time, respectively gives 0.3ml normal saline lumbar injection for 2nd～7 days, qd; Cisplatin adds the each group of unguentum of the present invention and within the 1st day, gives cisplatin 7mg/kg ^-1lumbar injection 1 time, 1-7 days by group give respectively 10,15g/kg ^-1unguentum of the present invention (oral drugs concentration difference, but every every day oral dose identical, be 2ml).All mices are got blood 0.5ml in the 4th day thorn eyeball and survey hematuria element ammonia (BUN), serum creatinine (Cr), N-acetyl-B-glucosaminidase (NAG).In the 8th day, de-whole mices cervical vertebra is put to death, dissect and get kidney immediately, 20% formalin is fixed, altogether 100 parts of kidney specimen are made pathologic finding.

1.4.3 the serology of tumor-bearing mice renal damage is changed:

Get 40 of inoculation S180 (Crocker sarcoma) mices, be divided at random 4 groups: normal saline (blank) group, alone cisplatin group, cisplatin add unguentum 10 of the present invention, 15g/kg ^-1group.Medication is the same, and gets blood examination in the 4th day and look into BUN, Cr, NAG enzyme.Within the 8th day, by all de-cervical vertebra execution of Mus, kidney is got in dissection immediately, does pathologic finding.

1.5 date processing

All experimental datas, after standardization, are carried out statistical analysis with Exce197, calculate corresponding F value, t value, and P value relatively.

2 results

2.1 impacts of various dose cisplatin on mouse kidney pathology

According to injecting normal saline, to the cumulative order of injection cisplatin dosage, also there is corresponding change in mouse kidney morphosis.Injection cisplatin 7mg/kg ^-1experimental group kidney interstitial congested obviously renal tubules (especially proximal convoluted tubule) water degeneration is obvious, there is the necrosis of renal tubules point lamellar in severe patient.And cisplatin dosage is less than 7mg/kg ^-1experimental group and matched group water Transitional Polar are light or without pathological changes.Cisplatin dosage is greater than 7mg/kg ^-1experimental group presents cast in the necrosis of typical renal tubules lamellar, renal tubules, manages all inflammatory cell infiltrations (wherein cisplatin dosage 15mg/kg ^-1experimental group 8d survival rate is only 37.5%), therefore use 7mg/kg ^-1cisplatin is test dose.

2.2 impacts on renal damage due to cisplatin

2.2.1 blank group is normal kidney structure.Cisplatin adds 2 dosage groups of unguentum of the present invention, no matter unguentum dosage size of the present invention, and renal tubules is slight water degeneration only, only at unguentum 10g/kg of the present invention ^-1group has an example to have spotty necrosis.And alone cisplatin group mouse kidney pathological changes is relatively serious, all there is the degeneration of obvious renal tubules water, there is kitchen range shape, lamellar renal tubules hemorrhagic necrosis in 8 examples.

2.2.2 respectively organize Biochemical index change in table 6.

Table 6

Note: with the comparison of cisplatin matched group, * P<0.05

3. conclusion: medicine of the present invention has the effect of the mouse kidney functional lesion due to protection chemotherapeutics cisplatin,

Experimental example 3: anxious malicious experimentation

1 experimental technique

Kunming mouse, through prerun, (method according to embodiment 1 is prepared to give the medicine agent of the present invention of gavage of white mice, but do not comprise the step that adds Mel) equal 1mL/20g, do not cause death, the concentration and the administration volume that are limited to medicine can not increase, and can not measure median lethal dose(LD 50) (LD50), therefore carry out maximum tolerance determination experiment.

Select 20 of healthy Kunming mouses, weight (20 ± 2) g, male and female half and half, with 24 hours in point gavage pharmaceutical composition unguentum of the present invention for 2 times, 1mL/ time, always measure and reach 100mL/kg, be equivalent to 163g/kg crude drug.This dosage is equivalent to 200 times of Coming-of-Age Day dosing.

2 experimental results

Mice, to observation post administration 7 days, has no untoward reaction, all bouncings, and Weight gain, without dead.

Compared with prior art, the present invention selects the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Amomi, Semen Astragali Complanati, Herba Artemisiae Anomalae, Radix Polygalae, Rhizoma Pinelliae Preparatum, Fructus Ligustri Lucidi, Radix Puerariae, Fructus Corni, Fructus Mori, Rhizoma Polygonati, Cortex Phellodendri, Radix Polygoni Multiflori Preparata, Fructus Alpiniae Oxyphyllae, Fructus Chaenomelis, raw Semen Ziziphi Spinosae, ripe Semen Ziziphi Spinosae, Radix Dipsaci, Rhizoma Cibotii, the Cortex Eucommiae, Fructus Lycii, Arillus Longan, Herba Epimedii, Rhizoma Curculiginis, Herba Cynomorii, Fructus Jujubae, Colla cornus cervi prescription, there is tonifying kidney, effect of tranquilizing by nourishing the heart, be applicable to sub-health state, hypoimmunity and carry out the male patient that biological immune treatment is in earlier stage taken good care of, can also improve chemicotherapy patient's renal dysfunction, the curative effect of medication of making is remarkable, have no side effect, reach goal of the invention.

Further illustrate by the following examples the present invention, but not as limitation of the present invention.

Detailed description of the invention:

Embodiment 1:

Prescription: Radix Rehmanniae 50g, Radix Rehmanniae Preparata 50g, Fructus Amomi 10g, Semen Astragali Complanati 50g, Herba Artemisiae Anomalae 30g, Radix Polygalae 10g, Rhizoma Pinelliae Preparatum 10g, Fructus Ligustri Lucidi 30g, Radix Puerariae 30g, Fructus Corni 50g, Fructus Mori 50g, Rhizoma Polygonati 50g, Cortex Phellodendri 30g, Radix Polygoni Multiflori Preparata 50g, Fructus Alpiniae Oxyphyllae 10g, Fructus Chaenomelis 10g, raw Semen Ziziphi Spinosae 30g, ripe Semen Ziziphi Spinosae 30g, Radix Dipsaci 50g, Rhizoma Cibotii 50g, Cortex Eucommiae 30g, Fructus Lycii 30g, Arillus Longan 30g, Herba Epimedii 40g, Rhizoma Curculiginis 40g, Herba Cynomorii 30g, Fructus Jujubae 30g, Colla cornus cervi 30g.

Technique: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three decocting liquids merge, and mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, separately gets the crystal sugar of 60g, add the boiled water of measuring with doubly, be heated to whole dissolvings, slowly add in above-mentioned extractum, stir, continue to receive cream with slow fire heating, wait to get a little energy horizontal drawing filamentation, or drip on paper not when water breakthrough mark, to obtain final product.

Usage and dosage: oral, sooner or later respectively once (before or after meals all can), each 15g, puts into hot water and melts rear oral; Also can directly swallow.

Embodiment 2:

Prescription: Radix Rehmanniae 50g, Radix Rehmanniae Preparata 50g, Fructus Amomi 10g, Semen Astragali Complanati 50g, Herba Artemisiae Anomalae 30g, Radix Polygalae 10g, Rhizoma Pinelliae Preparatum 10g, Fructus Ligustri Lucidi 30g, Radix Puerariae 30g, Fructus Corni 50g, Fructus Mori 50g, Rhizoma Polygonati 50g, Cortex Phellodendri 30g, Radix Polygoni Multiflori Preparata 50g, Fructus Alpiniae Oxyphyllae 10g, Fructus Chaenomelis 10g, raw Semen Ziziphi Spinosae 30g, ripe Semen Ziziphi Spinosae 30g, Radix Dipsaci 50g, Rhizoma Cibotii 50g, Cortex Eucommiae 30g, Fructus Lycii 30g, Arillus Longan 30g, Herba Epimedii 40g, Rhizoma Curculiginis 40g, Herba Cynomorii 30g, Fructus Jujubae 30g, Colla cornus cervi 30g.

Technique: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three decocting liquids merge, and mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20,75 DEG C of following conventional dryings become dry extract, be ground into fine powder, add the dextrin mix homogeneously of the amount of making 10%, with 75% alcohol granulation, dry, granulate, loads capsule, to obtain final product.

Usage and dosage: oral, one time 3,3 times on the one.

Embodiment: 3:

Prescription: Radix Rehmanniae 100g, Radix Rehmanniae Preparata 100g, Fructus Amomi 50g, Semen Astragali Complanati 100g, Herba Artemisiae Anomalae 60g, Radix Polygalae 50g, Rhizoma Pinelliae Preparatum 50g, Fructus Ligustri Lucidi 60g, Radix Puerariae 60g, Fructus Corni 100g, Fructus Mori 100g, Rhizoma Polygonati 100g, Cortex Phellodendri 60g, Radix Polygoni Multiflori Preparata 100g, Fructus Alpiniae Oxyphyllae 50g, Fructus Chaenomelis 50g, raw Semen Ziziphi Spinosae 600g, ripe Semen Ziziphi Spinosae 60g, Radix Dipsaci 100g, Rhizoma Cibotii 100g, Cortex Eucommiae 60g, Fructus Lycii 60g, Arillus Longan 60g, Herba Epimedii 80g, Rhizoma Curculiginis 80g, Herba Cynomorii 60g, Fructus Jujubae 60g, Colla cornus cervi 60g.

Technique: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, extractum is dry in 60 DEG C, and be ground into fine powder, add the mixed accessories of 25g to mix, mixed accessories is mixed with the ratio of 1:1 by microcrystalline Cellulose and corn starch, with 90% ethanol be wetting agent granule processed, dry in 60 DEG C after granulation, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain granule.

Usage and dosage: take a 10g, 3 times on the one after mixing it with hot water.

Embodiment: 4:

Prescription: Radix Rehmanniae 20g, Radix Rehmanniae Preparata 20g, Fructus Amomi 5g, Semen Astragali Complanati 20g, Herba Artemisiae Anomalae 10g, Radix Polygalae 5g, Rhizoma Pinelliae Preparatum 5g, Fructus Ligustri Lucidi 10g, Radix Puerariae 10g, Fructus Corni 20g, Fructus Mori 20g, Rhizoma Polygonati 20g, Cortex Phellodendri 10g, Radix Polygoni Multiflori Preparata 20g, Fructus Alpiniae Oxyphyllae 5g, Fructus Chaenomelis 5g, raw Semen Ziziphi Spinosae 10g, ripe Semen Ziziphi Spinosae 10g, Radix Dipsaci 20g, Rhizoma Cibotii 20g, Cortex Eucommiae 10g, Fructus Lycii 10g, Arillus Longan 10g, Herba Epimedii 10g, Rhizoma Curculiginis 10g, Herba Cynomorii 10g, Fructus Jujubae 10g, Colla cornus cervi 10g.

Technique: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, and mixes, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, the sucrose of separately getting 30g adds in the water boiling to be made to be uniformly dissolved, filter, make simple syrup; Simple syrup is added in extractum for subsequent use, add the sodium benzoate of 0.2g, boil dissolving, add pure water and be settled to 100ml, stir evenly, filter, embedding, obtains oral liquid.

Usage and dosage: oral, a 15ml, 3 times on the one.

Claims (10)

1. a pharmaceutical composition, it is characterized in that: calculate according to composition by weight, by Radix Rehmanniae 20-100 part, Radix Rehmanniae Preparata 20-100 part, Fructus Amomi 5-50 part, Semen Astragali Complanati 20-100 part, Herba Artemisiae Anomalae 10-60 part, Radix Polygalae 5-50 part, Rhizoma Pinelliae Preparatum 5-50 part, Fructus Ligustri Lucidi 10-60 part, Radix Puerariae 10-60 part, Fructus Corni 20-100 part, Fructus Mori 20-100 part, Rhizoma Polygonati 20-100 part, Cortex Phellodendri 10-60 part, Radix Polygoni Multiflori Preparata 20-100 part, Fructus Alpiniae Oxyphyllae 5-50 part, Fructus Chaenomelis 5-50 part, raw Semen Ziziphi Spinosae 10-600 part, ripe Semen Ziziphi Spinosae 10-60 part, Radix Dipsaci 20-100 part, Rhizoma Cibotii 20-100 part, Cortex Eucommiae 10-60 part, Fructus Lycii 10-60 part, Arillus Longan 10-60 part, Herba Epimedii 10-80 part, Rhizoma Curculiginis 10-80 part, Herba Cynomorii 10-60 part, Fructus Jujubae 10-60 part, Colla cornus cervi 10-60 part and adjuvant are prepared from.

2. pharmaceutical composition as claimed in claim 1, it is characterized in that: calculate according to composition by weight, by 50 parts, the Radix Rehmanniae, 50 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Amomis, 50 parts of Semen Astragali Complanatis, 30 parts of Herba Artemisiae Anomalaes, 10 parts of Radix Polygalaes, 10 parts of Rhizoma Pinelliae Preparatum, 30 parts of Fructus Ligustri Lucidi, 30 parts of Radix Puerariaes, 50 parts of Fructus Cornis, 50 parts of Fructus Mori, 50 parts of Rhizoma Polygonatis, 30 parts of Cortex Phellodendris, 50 parts of Radix Polygoni Multiflori Preparata, 10 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Fructus Chaenomeliss, 30 parts of raw Semen Ziziphi Spinosaes, 30 parts of ripe Semen Ziziphi Spinosaes, 50 parts of Radix Dipsaci, 50 parts of Rhizoma Cibotii, 30 parts of the Cortexs Eucommiae, 30 parts of Fructus Lyciis, 30 parts of Arillus Longans, 40 parts of Herba Epimedii, 40 parts of Rhizoma Curculiginises, 30 parts of Herba Cynomoriis, 30 parts of Fructus Jujubaes, 30 parts of Colla cornus cervis and adjuvant are prepared from.

3. prepare the method for pharmaceutical composition described in claim 1 or 2, it is characterized in that: proportionally all medical materials in the side of taking, combine with acceptable pharmaceutic adjuvant in medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.

4. the preparation method of pharmaceutical composition as claimed in claim 3, it is characterized in that: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, filtrate is condensed into extractum, combine with acceptable pharmaceutic adjuvant in medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.

5. the preparation method of pharmaceutical composition as described in claim 3 or 4, is characterized in that: described pharmaceutical preparation is soft extract, hard capsule, ointment, tablet, granule, pill, oral liquid, syrup, powder, sublimed preparation, suspensoid, solution, injection, freeze-dried powder, bulk capacity injection, suppository, plaster, cream, spray or patch.

6. the preparation method of pharmaceutical composition as claimed in claim 5, is characterized in that: described pharmaceutical preparation is soft extract, capsule, granule or oral liquid.

7. the preparation method of pharmaceutical composition as claimed in claim 6, it is characterized in that: described soft extract is prepared like this: take each medical material according to prescription ratio, add after 8 times of water gagings soak 0.5h and decoct 3 times, each 1h, three times decocting liquid merges, mix, be condensed into original liquid 80% time, filtered while hot, the extractum that when filtrate is concentrated into 60 DEG C, relative density is 1.15-1.20, separately get the crystal sugar of the amount of making 20%, add the boiled water of measuring with doubly, be heated to whole dissolvings, slowly add in above-mentioned extractum, stir, continue to receive cream with slow fire heating, wait to get a little energy horizontal drawing filamentation, or drip on paper not when water breakthrough mark, obtain.

As claimed in claim 1 or 2 pharmaceutical composition in the purposes of improving aspect the damage of chemicotherapy renal function of patients.

9. the application of pharmaceutical composition aspect tonifying kidney or tranquilizing by nourishing the heart effect as claimed in claim 1 or 2.

10. pharmaceutical composition is improving male's sub-health state, is improving immunity or carry out biological immune and treat the purposes aspect taking good care of early stage as claimed in claim 1 or 2.