Tu benefit chrysanthemum pharmaceutical composition and premix material, concentrate feed, batch and purposes
Technical field
The present invention relates to and a kind of improve egg production for egg fowl, extend laying period, improve Egg Quality, improve the Tu benefit chrysanthemum pharmaceutical composition of premunition, preparation method and containing the premix material of this pharmaceutical composition, concentrate feed, batch and purposes, belongs to veterinary drug and premix material field.
Background technology
China's egg fowl aquaculture achieves high speed development, it is achieved that the world-class good result of industry size, but the egg fowl level of production is still relatively low at present.For laying hen, the general breeding cycle of China is 65-72 week old, lays eggs about 250 year, 15-17 kilogram, feedstuff-egg ratio 2.5-2.8:1, death rate > 25%.The breeding cycle of World Developed Countries is 72-84 week old, lays eggs more than 300 year, 18-20 kilogram, feedstuff-egg ratio 2.2-2.3:1, death rate < 10%.Not only the egg fowl level of production is low in China, and Egg Quality is not good enough.Due to the continuous laying period abuse of antibiotics of disease, the regulation of non-strict implement off-drug period again, cause that egg antibiotic exceeds standard;What is more in order to pursue yolk color, adds the contrabands such as tonyred in feedstuff, causes society's worry to food-safety problem.Owing to the laying hen proctoptosis problem that feeding and management is improper, vitamin deficiency, disease, high yield load cause greatly is also that laying hen produces FAQs in reality, if prevention is not in time, not only result in egg production to decline, laying hen even can be caused to eliminate or dead, have a strong impact on egg fowl fanning economics.Therefore developing and improve egg fowl production performance, improve laying rate, extend laying period, improve Egg Quality, the high effective green environmentally friendly medicine improving premunition becomes the task of top priority.
Chinese medicine has been demonstrated to have biological activity widely, and growth promotion, raising produce performance, raising immunity, enhancing premunition, antiviral is antibacterial, improve Egg Quality etc..Composition of prescription application between Chinese medicine plays vital effect for improving effect, reducing toxicity, owing to prescription not science, compatibility are improper, improper use, not only do not reach expected effect, can the people of egg fowl or table egg goods be caused damage on the contrary.It is thus desirable to hold reasonable Chinese prescription and principle of medication, the effect got twice the result with half the effort could be obtained.
Summary of the invention
Phase, improve Egg Quality, improve premunition Tu benefit chrysanthemum pharmaceutical composition include following weight parts component: Chinese medicinal components 40-70 part, vitamin 5-15 part, organic acid 10-40 part;Described Chinese medicinal components is made up of the component of following weight parts: Semen Cuscutae 5-50 part, Herba Taxilli 5-25 part, Radix Astragali 5-25 part, Rhizoma Atractylodis Macrocephalae 5-25 part, Herba Leonuri 5-40 part, Flos Carthami 5-40 part, Calendula officinalis 5-40 part, Flos Tagetis Erectae 5-40 part, Cortex Cinnamomi 5-25 part.
In a further preferred embodiment, the Tu benefit chrysanthemum pharmaceutical composition improving egg fowl egg production, extending laying period, improve Egg Quality, improve premunition of the present invention includes following weight parts component: Chinese medicinal components 50-65 part, vitamin 6-10 part, organic acid 20-35 part;Described Chinese medicinal components is made up of the component of following weight parts: Semen Cuscutae 15-45 part, Herba Taxilli 10-20 part, Radix Astragali 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Herba Leonuri 10-30 part, Flos Carthami 15-30 part, Calendula officinalis 15-30 part, Flos Tagetis Erectae 15-30 part, Cortex Cinnamomi 10-20 part.
In further preferred embodiment, the Tu benefit chrysanthemum pharmaceutical composition improving egg fowl egg production, extending laying period, improve Egg Quality, improve premunition of the present invention includes following weight parts component: Chinese medicinal components 60 parts, vitamin 8 parts, organic acid 32 parts;Described Chinese medicinal components is made up of the component of following weight parts: Semen Cuscutae 35 parts, Herba Taxilli 15 parts, the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba Leonuri 25 parts, 25 parts of Flos Carthami, Calendula officinalis 25 parts, Flos Tagetis Erectae 25 parts, Cortex Cinnamomi 15 parts.
Wherein, described vitamin component is made up of the component of following weight parts: vitamin A 0.1-10 part, vitamin D 0.01-0.1 part, vitamin e1-30 parts, vitamin C 10-200 part;Preferably it is made up of the component of following weight parts: vitamin A 0.5-5 part, vitamin D 0.02-0.08 part, vitamin E 5-25 part, vitamin C 50-150 part, is more preferably made up of the component of following weight parts: retinol1-4 parts, vitamin D 0.04-0.06 part, vitamin e1 0-20 part, vitamin C 80-120 part;Most preferably it is made up of the component of following weight parts: 3-Hydroxyretinol part, vitamin D 0.05 part, vitamin e1 5 parts, vitamin C 100 parts.
Wherein, described organic acid composition is made up of the component of following weight parts: citric acid 1-100 part, malic acid 1-100 part;Preferably it is made up of the component of following weight parts: citric acid 10-80 part, malic acid 10-80 part;More preferably it is made up of the component of following weight parts: citric acid 30-60 part, malic acid 30-60 part;Most preferably it is made up of the component of following weight parts: citric acid 50 parts, malic acid 50 parts.
The preparation method that present invention also offers this pharmaceutical composition, it comprises the steps:
(1) weigh each taste Chinese medicine by weight ratio respectively, Semen Cuscutae, Herba Taxilli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Leonuri, Flos Carthami, Calendula officinalis, Flos Tagetis Erectae, Cortex Cinnamomi powder are broken into fine powder, sieve, mix homogeneously, obtain Chinese medicinal components;
(2) weigh vitamin component by weight ratio respectively, by vitamin A, vitamin D, vitamin E, vitamin C, sieve, mix homogeneously, obtain vitamin component;
(3) weigh organic acid composition by weight ratio respectively, citric acid, malic acid are sieved, mix homogeneously, obtain organic acid composition;
(4) by weight weighing Chinese medicinal components, vitamin and organic acid respectively again, by three's mix homogeneously, to obtain final product.
Tu benefit chrysanthemum pharmaceutical composition of the present invention can be used for preparation and improves egg fowl egg production, extends laying period, improves Egg Quality, improves the medicine of premunition.
Tu benefit chrysanthemum Chinese medicine component and consumption thereof in pharmaceutical composition of the present invention get by repeatedly practising in a large number.Tu benefit chrysanthemum pharmaceutical composition of the present invention can be used for improving egg fowl egg production, extends laying period, improves Egg Quality, improves premunition.
Tu benefit chrysanthemum pharmaceutical composition of the present invention also can add in feedstuff, is used for preparing the somatotrophic feedstuff of fowl, such as conventional premix material, the feedstuff such as concentrate feed and batch.
The present invention adopts Chinese medicine and the additive combination method such as vitamin, organic acid to improve the egg fowl level of production, increase egg production, extend laying period, improve Egg Quality, improve premunition, plays cooperative effect, obtains remarkable efficacy.Chinese medicine the liver and the kidney tonifying, restores menstrual flow and invigorates blood circulation, spleen benefiting and stimulating the appetite, anti-inflammation, Semen Cuscutae kidney invigorating and YANG supporting in side, nourishing the liver benefit essence, promotes Development of Reproductive System, promotes follicle maturity, and Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, the meridian dredging, benefit blood, for monarch drug;Herba Leonuri, Flos Carthami blood circulation promoting and blood stasis dispelling, strengthen reproductive system function, for ministerial drug;The Radix Astragali rises mends air, and Rhizoma Atractylodis Macrocephalae strengthening the spleen and stomach improves feed intake, for adjuvant drug;Calendula officinalis, Flos Tagetis Erectae promoting flow of QI and blood, anti-inflammation, Cortex Cinnamomi promoting blood circulation, kidney-Yang invigorating, warming the spleen and stomach, also there is increase yolk color and add the effect of perfume, for making medicine.All medicines share, and play benefit essence altogether and train the merit of unit, promoting blood circulation to remove obstruction in the collateral, anti-inflammation.Vitamin improves immunity, promotes Development of Reproductive System, promotes to lay eggs, and promotes that eggshell generates.Organic acid has raising and produces performance, improves the feature of body disease-resistant power, growth promotion, anti-bacteria and anti-virus, and the two shares with Chinese medicine, can play synergism, thus improving egg fowl egg production, extending laying period, improve Egg Quality, improving premunition.The adopted name that present invention exploitation is new veterinary drugs is Tu benefit chrysanthemum, and trade mark is how precious happy.
The present invention for improving egg fowl egg production, extend laying period, improve Egg Quality, improve the advantage of premunition pharmaceutical composition and have the beneficial effects that:
(1) present invention is Chinese medicine and western medicine compound preparation, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating both the principal and secondary aspects of a disease;
(2) the pharmaceutical composition reasonable recipe of the present invention, science;
(3) pharmaceutical composition good effect of the present invention, instant effect, easy to use, safe;
(4) drug combination preparation of the present invention is stable, preparation technology is simple, with low cost, constant product quality, controlled, there is the stronger market competitiveness.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
(1) Chinese crude drug containing following weight parts is weighed: Semen Cuscutae 1 part, Herba Taxilli 1 part, the Radix Astragali 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, Herba Leonuri 1 part, 1 part of Flos Carthami, Calendula officinalis 1 part, Flos Tagetis Erectae 1 part, Cortex Cinnamomi 1 part, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: vitamin A 0.1 part, vitamin D 0.01 part, vitamin e1 part, vitamin C 10 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 1 part, malic acid 1 part, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 30 parts, vitamin 1 part, organic acid 5 parts, mix homogeneously, to obtain final product.
Embodiment 2
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 60 parts, Herba Taxilli 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Herba Leonuri 50 parts, 50 parts of Flos Carthami, Calendula officinalis 50 parts, Flos Tagetis Erectae 50 parts, Cortex Cinnamomi 30 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: retinol1 0 part, vitamin D 0.1 part, vitamin E 30 parts, Catergen 00 part, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 100 parts, malic acid 100 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 80 parts, vitamin 20 parts, organic acid 50 parts, mix homogeneously, to obtain final product.
Embodiment 3
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 5 parts, Herba Taxilli 5 parts, the Radix Astragali 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Herba Leonuri 5 parts, 5 parts of Flos Carthami, Calendula officinalis 5 parts, Flos Tagetis Erectae 5 parts, Cortex Cinnamomi 5 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: vitamin A 0.5 part, vitamin D 0.02 part, vitamin E 5 parts, vitamin C 50 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 10 parts, malic acid 10 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 40 parts, vitamin 5 parts, organic acid 10 parts, mix homogeneously, to obtain final product.
Embodiment 4
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 50 parts, Herba Taxilli 25 parts, the Radix Astragali 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Herba Leonuri 40 parts, 40 parts of Flos Carthami, Calendula officinalis 40 parts, Flos Tagetis Erectae 40 parts, Cortex Cinnamomi 25 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: vitamin A 5 parts, vitamin D 0.08 part, vitamin E2 5 parts, vitamin C 150 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 80 parts, malic acid 80 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 70 parts, vitamin 15 parts, organic acid 40 parts, mix homogeneously, to obtain final product.
Embodiment 5
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 15 parts, Herba Taxilli 10 parts, the Radix Astragali 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Leonuri 10 parts, 15 parts of Flos Carthami, Calendula officinalis 15 parts, Flos Tagetis Erectae 15 parts, Cortex Cinnamomi 10 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: retinol1 part, vitamin D 0.04 part, vitamin e1 0 part, vitamin C 80 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 30 parts, malic acid 30 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 50 parts, vitamin 6 parts, organic acid 20 parts, mix homogeneously, to obtain final product.
Embodiment 6
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 45 parts, Herba Taxilli 20 parts, the Radix Astragali 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Herba Leonuri 30 parts, 30 parts of Flos Carthami, Calendula officinalis 30 parts, Flos Tagetis Erectae 30 parts, Cortex Cinnamomi 20 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicine ingredients.
(2) weighing the vitamin containing following weight: vitamin A 4 parts, vitamin D 0.06 part, vitamin E2 0 part, vitamin C 120 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 60 parts, malic acid 60 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 65 parts, vitamin 10 parts, organic acid 35 parts, mix homogeneously, to obtain final product.
Embodiment 7
(1) Chinese crude drug containing following weight is weighed: Semen Cuscutae 35 parts, Herba Taxilli 15 parts, the Radix Astragali 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Herba Leonuri 25 parts, 25 parts of Flos Carthami, Calendula officinalis 25 parts, Flos Tagetis Erectae 25 parts, Cortex Cinnamomi 15 parts, traditional Chinese medicine powder is broken into fine powder, sieving, mix homogeneously is standby as Chinese medicinal components.
(2) weighing the vitamin containing following weight: 3-Hydroxyretinol part, vitamin D 0.05 part, vitamin e1 5 parts, vitamin C 100 parts, sieve, mix homogeneously is standby as vitamin component.
(3) weighing the organic acid containing following weight: citric acid 50 parts, malic acid 50 parts, sieve, mix homogeneously is standby as organic acid composition
(4) weigh following weight composition more respectively: Chinese medicinal components 60 parts, vitamin 8 parts, organic acid 32 parts, sieve, mix homogeneously, to obtain final product.
For showing that pharmaceutical composition of the present invention improves egg fowl egg production, extends laying period, improves Egg Quality, improves premunition effect, this pharmaceutical composition has been carried out clinical observation on the therapeutic effect test by applicant further, and the beneficial effect of of the present invention medicine is expanded on further below by way of test example.
The observation that the brown Layer Production Performance of Luo Man and Egg Quality are affected by test example 1
300 25 brown laying hens of week old Luo Man are randomly divided into 5 process, each process 6 repetition, 10 chickens of each repetition.1-4 process group gives embodiment 1, embodiment 3, embodiment 5 and 7 pharmaceutical compositions of embodiment respectively, adds 500 grams by feedstuff per ton, feeds 8 weeks continuously;5th process group is blank group, is only given the feedstuff being not added with any medicine.Adopting 3 layers to raise in cages, 2 chickens of every cage, free choice feeding, freely drink water, illumination every day 16 hours, hen house artificial ventilation is ventilated, temperature about 15 DEG C, and every day, clear excrement was swept 1 time, keeps air quality in house good.Observe chicken group's mental status, egg type during test, record feed intake, egg number, abnormal-shape egg number (containing without shell egg), calculate feedstuff-egg ratio, laying rate, abnormal-shape egg rate, weigh egg size, measure yolk color.Indices computing formula is as follows:
Total egg number (individual)/(laying hen number (individual) × test natural law) × 100 in laying rate (%)=experimental period
Feedstuff-egg ratio=feedstuff total flow (kg)/total egg size (kg)
Abnormal-shape egg rate (%)=abnormal-shape egg number (individual)/total egg number (individual) × 100
Result of the test is in Table 1.
The result of the test that the brown Layer Production Performance of Luo Man and Egg Quality are affected by table 1
Group |
Laying rate (%) |
Feedstuff-egg ratio |
Abnormal-shape egg rate (%) |
Yolk color |
1 group |
96.02±10.98a |
2.08±0.36 a |
0 |
6.98±0.79 a |
2 groups |
96.24±9.57a |
2.01±0.95 a |
0 |
7.09±1.21 a |
3 groups |
96.21±6.71a |
1.96±1.56 a |
0 |
7.12±0.97 a |
4 groups |
98.03±3.16a |
1.91±0.45 a |
0 |
7.31±0.86 a |
5 groups |
80.12±15.87b |
2.66±1.29 b |
3.82±0.76 |
5.52±2.12 b |
Note: take on marking-up mother's difference with column data and represent significant difference (P<0.05), takes on marking-up parent phase with representing difference not notable (P>0.05) with column data.
Result of the test shows, compared with blank group, embodiment 1, embodiment 3, embodiment 5 and embodiment 7 pharmaceutical composition can significantly improve laying rate, improve Egg Quality, improve production performance.
The test example 2 observation on sea blue brown Layer Production Performance impact and prevention disease effects
The blue brown laying hen in 45 week old seas, 2500, laying hen field, Hebei is randomly divided into 5 groups, respectively A group, B group, C group, D group and E group, often 500 blue brown laying hens in sea of group, wherein A-D group gives embodiment 2, embodiment 4, embodiment 6 and embodiment 7 pharmaceutical composition respectively, add 500 grams by feedstuff per ton, feed 6 weeks continuously;E group is given only the feedstuff being not added with any medicine.Egg number, egg production, abnormal-shape egg number and proctoptosis situation observed and recorded, laying rate, abnormal-shape egg rate, proctoptosis rate calculated.Laying rate, abnormal-shape egg rate computational methods are the same, and proctoptosis rate computing formula is as follows:
Proctoptosis rate (%)=generation proctoptosis laying hen number (only)/total laying hen number (only) × 100
Result of the test is in Table 2.
Table 2 is on sea blue brown Layer Production Performance impact and prophylactic result of the test
Group |
Egg number (individual) |
Laying rate (%) |
Abnormal-shape egg rate (%) |
Proctoptosis rate (%) |
A group |
19971 |
95.1 |
0 |
0 |
B group |
20076 |
95.6 |
0 |
0 |
C group |
20118 |
95.8 |
0 |
0 |
D group |
20286 |
96.6 |
0 |
0 |
E group |
15771 |
75.1 |
3.7 |
5.75 |
Result of the test shows, compared with blank group, embodiment 2, embodiment 4, embodiment 6 and embodiment 7 pharmaceutical composition all can significantly improve the production performance of the blue brown laying hen in sea, improve laying rate, reduces abnormal-shape egg rate, the generation of prevention proctoptosis.
The test example 3 observation on the duck egg laying performance impact that continues
The duck that 460 40 week old of Xiaoshan, Zhejiang duck field continued is randomly divided into 2 groups, often 230 ducks that continue of group, and the 1st group gives embodiment 7 pharmaceutical composition and keep healthy, and feedstuff per ton adds 500 grams, feeds 4 weeks continuously;2nd group is given only the feedstuff being not added with any medicine.Observing and record egg number, egg production, laying rate computational methods are the same.Result of the test is in Table 3.
The table 3 result of the test on the duck egg laying performance impact that continues
Group |
Egg number (individual) |
Laying rate (%) |
1st group |
6106 |
94.8 |
2nd group |
4624 |
71.8 |
Result of the test shows, compared with blank group, the embodiment of the present invention 7 pharmaceutical composition can significantly improve the duck that continues and produce performance, improves laying rate.
The test example 4 observation on the impact of Beijing Cold boiled chicken egg laying performance and prevention disease effects
1000, laying hen field, Beijing, 50 week old Beijing Cold boiled chicken being randomly divided into 2 groups, often group 500, A group gives embodiment 7 pharmaceutical composition and keeps healthy, and feedstuff per ton adds 500 grams, feeds 4 weeks continuously;B group is given only the feedstuff being not added with any medicine.Observing and record egg number, egg production, a situation arises for proctoptosis, and laying rate, proctoptosis rate computational methods are the same.Result of the test is in Table 4.
Table 4 is on the impact of Beijing Cold boiled chicken egg laying performance and prophylactic result of the test
Group |
Egg number (individual) |
Laying rate (%) |
Proctoptosis rate (%) |
A group |
13552 |
96.7 |
0 |
B group |
11690 |
83.5 |
6.2 |
Result of the test shows, compared with blank group, the embodiment of the present invention 7 pharmaceutical composition can significantly improve Beijing Cold boiled chicken and produce performance, improves laying rate, prophylactic generation.
The above is only the preferred embodiment of the present invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the technology of the present invention principle; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.