CN106421154A - Traditional Chinese medicine composition and traditional Chinese medicine preparation containing Chinese eaglewood wood and having cell repairing, anti-aging and anti-canter functions as well as preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition and traditional Chinese medicine preparation containing Chinese eaglewood wood and having cell repairing, anti-aging and anti-canter functions as well as preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine composition and a traditional Chinese medicine preparation containing Chinese eaglewood wood and having cell repairing, anti-aging and anti-canter functions as well as a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition containing the Chinese eaglewood wood is prepared from raw materials in parts by weight as follows: 10-40 parts of the Chinese eaglewood wood, 10-40 parts of shiitake, 2-8 parts of phellinus, 10-30 parts of hairyvein agrimonia herb, 10-30 parts of ganoderma lucidum, 5-15 parts of milkvetch root, 2-8 parts of taxus chinensis, 3-12 parts of toad and 2-8 parts of scorpion. The traditional Chinese medicine composition containing the Chinese eaglewood wood has better anti-cancer function, smaller toxic and side effects and remarkable cancer treating effect, and particularly has unexpected excellent curative effect on advanced cancer which surgery, radiotherapy and chemotherapy are not suitable for or is proved to be ineffective after surgery, radiotherapy and chemotherapy; the traditional Chinese medicine composition containing the Chinese eaglewood wood has functions of inhibiting melanocytes and tyrosinase and resisting free radicals and has a remarkable anti-aging function.
Description
Technical field
The invention belongs to Lignum Aquilariae Resinatum technical field of traditional Chinese medicine preparation, more particularly it relates to one kind has repair cell, resists
Aging, the Lignum Aquilariae Resinatum Chinese medicine composition of anti-cancer function, Chinese medicine preparation and preparation method thereof.
Background technology
Health and longevity are exactly the common aspiration of the mankind and a major issue of general concern since ancient times.With people's life
The continuous improvement of level, people increasingly thirst for health, look forward to longevity.Chinese traditional Chinese medicine declines for delaying people
Always, improve the life-span of people, health invigorating, prevention disease, life lengthening, salubrity diseases prevention, have long history and unique treatment
Effect.Have substantial amounts of achievement in research it is shown that defying age, life lengthening are scientific, in decades, China human mortality flat
All the life-span improves constantly, and long lived elder gets more and more, and more excites people to go to explore the secret that how can be only achieved longevity, explores anti-
Aging, the method for life lengthening, application health protection with Chinese medicine is exactly one of method.Traditional Chinese medicine health-preserving method is natural materials (Chinese medicine) health care
Class medicine, Chinese medicine is natural materials (some Chinese medicines also can medicine-food two-purpose) mostly, wherein contains the abundant various human bodies that are beneficial to and is good for
The abundant effective ingredient of health and nutrient substance needed by human.Scientifically prepare, application Chinese medicine takes care of health medicine, can pacify for a long time
Entirely take, untoward reaction will not be produced.It is generally believed that the action effect of anti aging effect active substance includes removing free radical,
Improve cell proliferation rate, delay the degradation speed of extracellular matrix.
With the progress of medical science, general sexually transmitted disease is gradually controlled, and malignant tumor cancer, become common and tight
Threaten one of human life and the principal disease of quality of life again.The tumour patient that the whole world is newly made a definite diagnosis every year since 1996 is all
More than 10,000,000, more than dead 700 ten thousand people, exceed 40,000,000 people to 1999 end of the year whole world tumour patient sums.The tumor of China
Sickness rate is equally very surprising, it has also become the 2nd dead big reason of China human mortality.According to Ministry of Public Health statistics the nineties China tumor
Sickness rate has gone up as 0.127%.In past 20 years, totally the gesture in rising (also had sending out of minority cancer to tumor incidence certainly
Sick rate is more stable or declines).Domestic in recent years newly-increased every year tumour patient more than 200 ten thousand people, about more than dead 130 ten thousand people,
National tumor patient Estimate of Total Number is about 4,500,000 people at present.
Existing anti-tumor medicine thing is more, such as cyclophosphamide, 5-fluorouracil, cytosine arabinoside, bleomycin, Changchun
Alkali, harringtonine, cisplatin, carboplatin etc., but they not only kill the cancerous cell of local, and can kill thin in vain in bone marrow
Born of the same parents, cause leukopenia, lead to patient to be susceptible to suffer from infectious disease, and chemotherapeutic also can affect myeloid element and generation blood is little
The ability of plate, makes patient encounter very slight damage, will also result in bleeding or internal hemorrhage, in addition, the Secondary cases that chemotherapy causes swell
Tumor may occur after many years；Existing chemotherapeutics still have some following side effect, such as：Nausea and vomiting, detest
Food, alopecia, stomatitis, allergic rash, liver function injury and Abwehrkraft des Koepers decline, situations such as the various infection of easy secondary,
Some chemotherapeutics also can damage cell of heart, kidney, bladder, lung and nervous system etc., and these all can increase the pain of patient
Hardship, the quality of life of impact patient, therefore its application has larger restriction.
In theory, early diagnosis, early treatment, early metaphase are performed the operation, chemicotherapy just has the healing chance of minority, but most patient
Just have developed into middle and advanced stage because when subjective symptomss are gone to a doctor, so early treatment is often wonderful dream.Chinese traditional treatment cancer
Method be currently used primarily in alleviation patient symptom, improve the quality of living, as operative treatment and the complementary means of chemicotherapy, have
There is the Chinese medicine of therapeutic effect still rare.
It would therefore be highly desirable to Chinese medicinal compound is carried out deeper into research, further find can give full play to active anticancer
Formula, provides new approach for curing cancer.
Content of the invention
Based on this, in order to overcome the defect of above-mentioned prior art, the invention provides one kind has repair cell, anti-ageing
Always, the Lignum Aquilariae Resinatum Chinese medicine composition of anti-cancer function, Chinese medicine preparation and preparation method thereof, can effectively defying age and anticancer.
In order to realize foregoing invention purpose, this invention takes technical scheme below：
A kind of Lignum Aquilariae Resinatum Chinese medicine composition with repair cell, defying age, anti-cancer function, described Chinese medicine composition is by following
The raw material of weight portion is prepared：Lignum Aquilariae Resinatum 10-40 part, Lentinus Edodess 10-40 part, Phellinus igniarius (L. ex Fr.) Quel. 2-8 part, Herba Agrimoniae 10-30 part, Ganoderma 10-
30 parts, Radix Astragali 5-15 part, Ramulus et folium taxi cuspidatae 2-8 part, Bufo siccuss 3-12 part, Scorpio 2-8 part.
Wherein in some embodiments, described Chinese medicine composition is prepared by the raw material of following weight portion：Lignum Aquilariae Resinatum 15-30
Part, Lentinus Edodess 15-30 part, Phellinus igniarius (L. ex Fr.) Quel. 4-8 part, Herba Agrimoniae 12-18 part, Ganoderma 12-18 part, Radix Astragali 8-12 part, Ramulus et folium taxi cuspidatae 4-8 part, toad
Bufonid toad 5-10 part, Scorpio 4-8 part.
Wherein in some embodiments, described Chinese medicine composition is prepared by the raw material of following weight portion：17 parts of Lignum Aquilariae Resinatum,
17 parts of Lentinus Edodess, 6 parts of Phellinus igniarius (L. ex Fr.) Quel., 15 parts of Herba Agrimoniae, 15 parts of Ganoderma, 10 parts of the Radix Astragali, 6 parts of Ramulus et folium taxi cuspidatae, 8 parts of Bufo siccuss, 6 parts of Scorpio.
Present invention also offers having the Lignum Aquilariae Resinatum Chinese medicine preparation of repair cell, defying age, anti-cancer function, described Chinese medicine preparation
Using above-mentioned Lignum Aquilariae Resinatum Chinese medicine composition as active component.
Wherein in some embodiments, the dosage form of described Lignum Aquilariae Resinatum Chinese medicine preparation is capsule, tablet or granule.
Present invention also offers the preparation of the above-mentioned Lignum Aquilariae Resinatum Chinese medicine composition with repair cell, defying age, anti-cancer function
Method, comprises the following steps：
1), art or low-temperature extraction art are distilled by High Temperature High Pressure, respectively obtain the Lignum Aquilariae Resinatum tetrol that skims the cream off milk of Lignum Aquilariae Resinatum, and
The fungus polysaccharide that skims the cream off milk of Lentinus Edodess, mixes；
2), add other raw materials of powder, mix, obtain final product.
Each crude drug of the Lignum Aquilariae Resinatum Chinese medicine composition with repair cell, defying age, anti-cancer function of the present invention has respectively
There is following effect：
Lignum Aquilariae Resinatum is as middle medical drugs simply, early on the books in Ancient Times in China.Record according to a lot of historical summaries, ancient Chinese medicine doctor is used
Lignum Aquilariae Resinatum is cured the disease, and have accumulated rich experience.Lignum Aquilariae Resinatum is the antibacterial seldom having in nature and the medical material strengthening immunologic function, its
Fragrant odour, enters lung, kidney, spleen, stomach, warp, is gilt-edged medical material in qi-activating drug, can adjust the operation of gas in human body, in dredging
Dirty function, is all highly effective medical material to lung, kidney, liver, stomach, intestinal heart etc..Current research finds：Lignum Aquilariae Resinatum is also significantly anti-
Cancer acts on.Lignum Aquilariae Resinatum tetrol in Lignum Aquilariae Resinatum plays very important effect for the defying age of the Chinese medicine composition of the present invention, anticancer.
Lentinus Edodess are rich in vitamin B complex, ferrum, potassium, provitamin D (changing into vitamin D after Exposure to Sunlight), sweet in the mouth, mild-natured.Cure mainly
Loss of appetite, few gas is weak.In Lentinus Edodess, Quantitative Determination of Ergosterol is very high, effective to preventing and treating ricketss；Fungus polysaccharide (β in Lentinus Edodess
～1,3 glucosans) cell immunocompetent can be strengthened, thus the growth of anticancer.People is made up of cell, and cell is by thin
Karyon, Cytoplasm, cell membrane composition.After cell is subject to the infringement of virus, antibacterial or free radical, cell membrane is first subjected to damage
Wound, once rupturing, Cell sap will outflow and lead to cell death.Substantial amounts of cell death will form disease, therefore, must
The cell damaging is repaired.Fungus polysaccharide has the bio-modification function of mystery, can repair impaired cell, so that the mankind is exempted from
Misery by disease.Fungus polysaccharide causes so all kinds of diseases and ailments can be controlled, entirely due to its biological activity.Fungus polysaccharide has reparation thin
Born of the same parents, raising immunologic function, are immune prosthetic nutrition truly.
Phellinus igniarius (L. ex Fr.) Quel. Phellinus igniarius (L.ex Fr.), is a kind of funguses, gains the name because parasitizing mulberry.Phellinus igniarius (L. ex Fr.) Quel.
It is a kind of rare Chinese medicine, can sharp the five internal organs, softening the hard mass, toxin expelling, hemostasis, promoting blood circulation, stomach function regulating antidiarrheal.Contribute to controlling gonorrhea, bleeding not during menses, disease
Abdominal mass is gathered, hypochondrium fluid retention, diarrhea due to hypofunction of the spleen.
Herba Agrimoniae another name Herba silenes fortunei, melon Rhizoma et radix valerianae, old tendon Bovis seu Bubali, wolf wheatgrass.Originate as rosaceous plant Agrimony Agrimonia
The aerial partss of pilosa Ledeb..Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, control epistaxis have specially good effect,
Malaria, de-power internal lesion caused by overexertion, carbuncle.
Ganoderma is also known as Lin Zhongling, fine jade treasure's (scientific name：Ganoderma Lucidum Karst) it is On Polyporaceae Ganoderma
Sporophore.There is invigorating QI and tranquilization, relieving cough and asthma, life lengthening.For dizziness sleeplessness, shortness of breath and palpitation, neurasthenia, void
Phthisical cough is breathed heavily.Ganoderan GLA, GLB, GLC all have suppression to the generation of superoxide anion (O) free radical and erythrocyte lipid peroxidation
Make and use, and have scavenging action to hydroxyl radical free radical (OH), there is superoxide dismutase sample activity, be Ganoderma slow down aging
Key factor.Rats gavaged is artificial and the heavy concentrate of natural glossy ganoderma decocting wine all can dramatically and suppresses carrageenin joint caused
Swollen.Ganoderma sporophore handle crude extract reaches 87.6% to mice S180 suppression ratio, and its composition contains polysaccharide and protein.Ganoderma hot water
Separate to obtain multiple polysaccharide lumbar injections in abstract, have inhibitory action to mice S180 transplanted tumor.Detached egg in Ganoderma
White polysaccharide lumbar injection can make cell in mouse peritoneal transudate, macrophage, polymorphonuclear leukocyte increase, and shows there is immunity
Booster action, substantially increases to the spleen Plaque forming cell number of sheep red blood cell (SRBC) (SRBC) immune mouse, this kind of polysaccharide
Containing galactose, glucose and xylose.One research is to observe the suppression to BEL-7702 and MGC-803 tumor cell for the Ganoderma extract
Make use, and observe their prevention administrations or therapeutic administratp to be exposed to chemotherapeutic and various dose Co gamma-rays irradiate under
Normal person's HL-7702 cell protective effect.Result shows, Ganoderma extract (based on Ganoderma triterpenoidss composition) is thin to tumor
The inhibitory action of born of the same parents is the strongest, when concentration is for 0.125mg/ml, suppression ratio 50%.Being processed with Ganoderma extract in advance to make damage
Substantially mitigate.The HL-7702 cell injury causing is irradiated to Co gamma-rays, Ganoderma extract has obvious antitumor in vitro
Effect, and the damage to the normal cell that lonizing radiation and chemotherapeutic cause has protective effect.
The medicinal of the Radix Astragali has the history of more than 2000 year so far, and it has enhancing human body immunity function, liver protection, diuresis, anti-ageing
Always, anti-stress, blood pressure lowering and wide antibacterial action.Antitumaous effect is mainly achieved in the following ways：1. reinforced immunological
Power, induction cancerous cell is voluntarily dead；2. the propagation of anticancer and transfer；3. mitigate the side effect of chemotherapy and radiation；4. delay
The solution distinctive pain of cancer patient；5. the cancerations such as ulcer, polyp, benign tumor are stoped to be cancer；6. prevent, avoid answering of cancer
Send out.
Ramulus et folium taxi cuspidatae, the whole world only this Chinese yew genus plants contain (taxoid), can be used for synthesizing anti-cancer medicine paclitaxel
(Paclitaxel, Taxol).
Bufo siccuss, taste raw meat, temperature, poisonous.Thoughts of returning home warp, the effects such as having removing toxic substances, pain relieving, have one's ideas straightened out.Folks of china traditional Chinese medical science medicine grinds
Study carefully development association to compile《Cancer uniqueness secret recipe》Middle load：Cutis Bufonis nature and flavor raw meat, cool, micro- poison, function removing toxic substances, diuretic, relieving distension, cure mainly various
Tumor.Through Shanghai Communications University's quantum medicine detection, especially the treatment effective content of cancer, liver cirrhosis, all diseases of pain is become within 1999
Point surpass on 8,000 amount valencys (all have more than 8,000 amount valencys to have immunologic function composition).Huaxia Press《The full allusion quotation of Traditional Chinese Medicine》Middle load：Toad
Clothing poison is lighter, is mainly used in sore swollen toxin and infantile malnutrition, modern conventional curing oncoma.Distant place publishing house《Chinese herbal medicine is complete works of》Intermediary
Continue, toad-cortex can for cancer, leukemia, lymphoma etc..Modern study is thought：The main alcoholic compound containing bufadienolide of toad-cortex, including toad
Malicious aglycon and bufotoxin, have heart tonifying, boosting, antiinflammatory action, the also stronger anesthetic action of bufalin.Scientific research personnel sends out
Existing toad-cortex also has multiple mystery function such as antitumor, antiviral, can be used for treating Several Kinds of Malignancy, hepatitis, herpes zoster, liver
The difficult miscellaneous diseases such as ascites, nephropathy, cyclomastopathy, hysteromyoma.
Scorpio, endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.For liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Compared with prior art, the invention has the advantages that：
1st, the pharmaceutical composition of the present invention has preferable antitumaous effect, and toxic and side effects are less, has significant treatment cancer
The effect of disease, especially to being not suitable for being performed the operation and chemicotherapy, or underwent operative and the invalid terminal cancer of chemicotherapy have pre-
Unimaginable excellent curative effect；
2nd, the pharmaceutical composition of the present invention has suppression melanocyte, suppression tryrosinase, the effect of free radical resisting, tool
There is significant anti-senescence function.
Specific embodiment
To describe the present invention below in conjunction with specific embodiment in detail.The raw material being related in following examples or reagent are such as no special
Different explanation, derives from commercially available, the conventional behaviour that the operation employed in following examples is well known to the skilled person
Make.
A kind of Lignum Aquilariae Resinatum Chinese medicine preparation (capsule) with repair cell, defying age, anti-cancer function of embodiment 1
, with following Chinese medicine composition as active component, Chinese medicine composition is by following for the described Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment
The raw material of weight portion is prepared：17 parts of Lignum Aquilariae Resinatum, 17 parts of Lentinus Edodess, 6 parts of Phellinus igniarius (L. ex Fr.) Quel., 15 parts of Herba Agrimoniae, 15 parts of Ganoderma, 10 parts of the Radix Astragali,
6 parts of Ramulus et folium taxi cuspidatae, 8 parts of Bufo siccuss, 6 parts of Scorpio.
The preparation method of the Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment, comprises the following steps：
1), art or low-temperature extraction art are distilled by High Temperature High Pressure, respectively obtain the Lignum Aquilariae Resinatum tetrol that skims the cream off milk of Lignum Aquilariae Resinatum, and
The fungus polysaccharide that skims the cream off milk of Lentinus Edodess, mixes；
2), add other raw materials of powder, mix, obtain final product Chinese medicine composition；
3), prepare capsule according to a conventional method, obtain Lignum Aquilariae Resinatum Chinese medicine preparation.
A kind of Lignum Aquilariae Resinatum Chinese medicine preparation (capsule) with repair cell, defying age, anti-cancer function of embodiment 2
, with following Chinese medicine composition as active component, Chinese medicine composition is by following for the described Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment
The raw material of weight portion is prepared：10 parts of Lignum Aquilariae Resinatum, 10 parts of Lentinus Edodess, 8 parts of Phellinus igniarius (L. ex Fr.) Quel., 30 parts of Herba Agrimoniae, 30 parts of Ganoderma, 5 parts of the Radix Astragali, red
2 parts of bean China fir, 12 parts of Bufo siccuss, 8 parts of Scorpio.
The preparation method of the Chinese medicine preparation of the present embodiment is same as Example 1.
A kind of Lignum Aquilariae Resinatum Chinese medicine preparation (tablet) with repair cell, defying age, anti-cancer function of embodiment 3
, with following Chinese medicine composition as active component, Chinese medicine composition is by following for the described Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment
The raw material of weight portion is prepared：40 parts of Lignum Aquilariae Resinatum, 40 parts of Lentinus Edodess, 2 parts of Phellinus igniarius (L. ex Fr.) Quel., 10 parts of Herba Agrimoniae, 10 parts of Ganoderma, 15 parts of the Radix Astragali,
8 parts of Ramulus et folium taxi cuspidatae, 3 parts of Bufo siccuss, 2 parts of Scorpio.
The preparation method of the Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment, comprises the following steps：
1), art or low-temperature extraction art are distilled by High Temperature High Pressure, respectively obtain the Lignum Aquilariae Resinatum tetrol that skims the cream off milk of Lignum Aquilariae Resinatum, and
The fungus polysaccharide that skims the cream off milk of Lentinus Edodess, mixes；
2), add other raw materials of powder, mix, obtain final product Chinese medicine composition；
3), prepare tablet according to a conventional method, obtain Lignum Aquilariae Resinatum Chinese medicine preparation.
A kind of Lignum Aquilariae Resinatum Chinese medicine preparation (tablet) with repair cell, defying age, anti-cancer function of embodiment 4
, with following Chinese medicine composition as active component, Chinese medicine composition is by following for the described Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment
The raw material of weight portion is prepared：15 parts of Lignum Aquilariae Resinatum, 15 parts of Lentinus Edodess, 8 parts of Phellinus igniarius (L. ex Fr.) Quel., 18 parts of Herba Agrimoniae, 18 parts of Ganoderma, 8 parts of the Radix Astragali, red
4 parts of bean China fir, 10 parts of Bufo siccuss, 8 parts of Scorpio.
The preparation method of the Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment is same as Example 3.
A kind of Lignum Aquilariae Resinatum Chinese medicine preparation (granule) with repair cell, defying age, anti-cancer function of embodiment 5
, with following Chinese medicine composition as active component, Chinese medicine composition is by following for the described Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment
The raw material of weight portion is prepared：30 parts of Lignum Aquilariae Resinatum, 30 parts of Lentinus Edodess, 4 parts of Phellinus igniarius (L. ex Fr.) Quel., 12 parts of Herba Agrimoniae, 12 parts of Ganoderma, 12 parts of the Radix Astragali,
8 parts of Ramulus et folium taxi cuspidatae, 5 parts of Bufo siccuss, 4 parts of Scorpio.
The preparation method of the Lignum Aquilariae Resinatum Chinese medicine preparation of the present embodiment, comprises the following steps：
1), art or low-temperature extraction art are distilled by High Temperature High Pressure, respectively obtain the Lignum Aquilariae Resinatum tetrol that skims the cream off milk of Lignum Aquilariae Resinatum, and
The fungus polysaccharide that skims the cream off milk of Lentinus Edodess, mixes；
2), add other raw materials of powder, mix, obtain final product Chinese medicine composition；
3), prepare granule according to a conventional method, obtain Lignum Aquilariae Resinatum Chinese medicine preparation.
The inhibitory action to cancerous cell for the Lignum Aquilariae Resinatum Chinese medicine composition of test example 1 embodiment of the present invention 1
First, mice is transplanted with the inhibitory action of S180
Animal：Kunming mouse, body weight 18-22g.
Medicine：The Lignum Aquilariae Resinatum Chinese medicine composition of embodiment 1, positive control Cytoxan, by the limited duty of Shanghai Hua Lian pharmacy
Ren company produces, and lot number 000103 is commercially available.
Tumor strain：S180 is purchased from Sichuan Industrial Institute of Antibiotics.
Test method：Aseptically, take tumor animal, put to death and fix, with iodine tincture and alcohol disinfecting operating position skin
Skin, then cuts, and the good tumor mass tissue of growth selection is put in tissue homogenate device, and the ratio in 1: 2 adds physiological saline solution
Make cell suspension, in test mice axillary fossa subcutaneous vaccination 0.2ml, inoculate 80 for every batch, next day random packet after inoculation, every group
10, dosage gastric infusion as shown in table 1, one time a day, continuous 10 days, puts to death mice, weigh, pluck tumor after last dose
Weigh, calculate tumour inhibiting rate, test is repeated 3 times.
Table 1 transplants the inhibitory action (X ± SD) of S180 to mice
| Group | Dosage (mg/kg) | n | Tumor weight (g) | Tumour inhibiting rate (%) |
| Lotus knurl matched group | 30 | 1.81±0.47 | ||
| Cyclophosphamide | 25(ip) | 30 | 0.64±0.37 | 64.64 |
| Lignum Aquilariae Resinatum Chinese medicine composition of the present invention | 200 | 30 | 0.75±0.32 | 58.56 |
From table 1 result of the test, the Lignum Aquilariae Resinatum Chinese medicine composition of the embodiment of the present invention 1 has bright to mouse transplanting tumor S180
Aobvious inhibitory action.
2nd, the inhibitory action to mice transplanted gastric cancer
Animal：Kunming mouse, body weight 18-22g.
Medicine：The Lignum Aquilariae Resinatum Chinese medicine composition of the embodiment of the present invention 1, is administered 200mg/Kg respectively.Positive control cyclome phosphinylidyne
Amine, is produced by Shanghai Hua Lian Pharmaceutical Co, lot number 000103, commercially available.
Tumor strain：Gastric cancer strain is purchased from Sichuan Industrial Institute of Antibiotics.
Test method：Aseptically, lotus knurl is taken to pass on Mus, skin of abdomen of sterilizing, with aseptic sky syringe pump abdomen
Water, makees 1: 2 times of dilution with physiological saline solution, takes female mice 80, every inoculation 0.2ml, after inoculation, next day divides at random
Group, every group 40, dosage gastric infusion as shown in table 2, one time a day, continuous 10 days, records the mouse survival time, calculates life
Rate elongation, test is repeated 3 times.
Table 2：Inhibitory action (X ± SD) to mice transplanted gastric cancer
| Group | Dosage (mg/kg) | n | Life span (d) | Increase in life span (%) |
| Lotus knurl matched group | 40 | 11.8±1.32 | ||
| Cyclophosphamide | 50(ip) | 40 | 16.8±2.51 | 42.37 |
| Lignum Aquilariae Resinatum Chinese medicine composition of the present invention | 200 | 40 | 17.4±1.87 | 47.46 |
From table 2 result of the test, the Lignum Aquilariae Resinatum Chinese medicine composition of the embodiment of the present invention 1 has significantly to mice transplanted gastric cancer
Inhibitory action, can be obviously prolonged the mouse survival time.
The clinical trial to treatment of cancer effect for the Lignum Aquilariae Resinatum Chinese medicinal tablet of test example 2 present invention
It is exemplified below part model case, to embody the Lignum Aquilariae Resinatum Chinese medicine preparation significantly effect for cancer of the present invention further.
1st, gastric cancer cases one
Patient：Jing Suohai, man, 53 years old.
Before medical：Stomach cancer metastasis, dyscrasia is serious, and body weight falls to 105 jin about from 160 jin.
Cancer therapy drug：Embodiment 1
Curative effect after medical：Daily above-mentioned anticancer pharmaceutical composition, after one month, weight in patients increases by 5 kilograms,
Recover to 130 jin, also grow a not only black but also thick hair, skin senile plaque loses.So far, survival is more than 6 years.
2nd, gastric cancer cases one
Patient：Lu Yunxi, female, 79 years old.
Before medical：Suffer from stomach cardiac cancer, Post operation shifts, and has the various symptoms such as stomach poor appetite, insomnia.Take plurality kinds of health care product,
Including commercially available polysaccharide health-care product, invalid.
Cancer therapy drug：Embodiment 2
Curative effect after medical：Daily above-mentioned anticancer pharmaceutical composition, after two months, patient's various symptoms are improved.3 years
Afterwards because heart disease is dead.
The clinical trial to anti-aging effects for the Lignum Aquilariae Resinatum Chinese medicinal tablet of test example 3 present invention
It is exemplified below part model case, imitated with the significant defying age of Lignum Aquilariae Resinatum Chinese medicine preparation embodying the present invention further
Really.
1st, king XX, man, in 58 years old this year, adheres to that the capsule taking embodiment 1 existing half a year is many, his rigidity of the body now daily
Strong, full of energy, energetic, stride is strong and vigorous, and sound is loud and clear, and great majority think that he is the people of one's mid-40s.
2nd, king XX, female, in 60 years old this year, feels cutis laxa, shallow complexion, takes the capsule one of embodiment 1 before medication
After month, cutis laxa is alleviated, and complexion gloss is fine and smooth, energetic.
3rd, Lee XX, man, 47 years old, adhere to the capsule of long-term taking embodiment 1, mental attitude is greatly taken on a new look, resistance strengthens,
Seem that its surface to volume ratio takes first young more than 5 years old.
4th, Xiao XX, female, 54 years old, insomnia was up to for more than 10 years, and work is a cup too low, and easily fatigue, takes the capsule one of embodiment 1
After individual month, sleep quality greatly takes on a new look, energetic, and effect is preferable.
5th, Shen XX, man, 67 years old, before medication, the mental status was poor, through adhering to taking the capsule 3 months of embodiment 1, spiritual face
Looks are greatly taken on a new look it appears that his ratio takes front youth more than 10 years old.
Embodiment described above only have expressed the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformation can also be made and improve, these broadly fall into the guarantor of the present invention
Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (6)
1. a kind of Lignum Aquilariae Resinatum Chinese medicine composition with repair cell, defying age, anti-cancer function is it is characterised in that in described Lignum Aquilariae Resinatum
Drug composition is prepared by the raw material of following weight portion：Lignum Aquilariae Resinatum 10-40 part, Lentinus Edodess 10-40 part, Herba Agrimoniae 10-30 part, Ganoderma
10-30 part, Radix Astragali 5-15 part, Ramulus et folium taxi cuspidatae 2-8 part, Bufo siccuss 3-12 part, Scorpio 2-8 part.
2. according to claim 1 have repair cell, defying age, anti-cancer function Chinese medicine composition it is characterised in that
Described Lignum Aquilariae Resinatum Chinese medicine composition is prepared by the raw material of following weight portion：Lignum Aquilariae Resinatum 15-30 part, Lentinus Edodess 15-30 part, Herba Agrimoniae
12-18 part, Ganoderma 12-18 part, Radix Astragali 8-12 part, Ramulus et folium taxi cuspidatae 4-8 part, Bufo siccuss 5-10 part, Scorpio 4-8 part.
3. according to claim 2 have repair cell, defying age, anti-cancer function Chinese medicine composition it is characterised in that
Described Lignum Aquilariae Resinatum Chinese medicine composition is prepared by the raw material of following weight portion：20 parts of Lignum Aquilariae Resinatum, 20 parts of Lentinus Edodess, 15 parts of Herba Agrimoniae, spirit
15 parts of sesame, 10 parts of the Radix Astragali, 6 parts of Ramulus et folium taxi cuspidatae, 8 parts of Bufo siccuss, 6 parts of Scorpio.
4. a kind of Lignum Aquilariae Resinatum Chinese medicine preparation with repair cell, defying age, anti-cancer function is it is characterised in that described Lignum Aquilariae Resinatum Chinese medicine
Lignum Aquilariae Resinatum Chinese medicine composition described in using any one of claims 1 to 3 for the preparation is as active component.
5. the Chinese medicine preparation with repair cell, defying age, anti-cancer function according to claim 4 is it is characterised in that institute
The dosage form stating Lignum Aquilariae Resinatum Chinese medicine preparation is capsule, tablet or granule.
6. the preparation of the Chinese medicine composition with repair cell, defying age, anti-cancer function described in any one of claims 1 to 3
Method is it is characterised in that comprise the following steps：
1), art or low-temperature extraction art are distilled by High Temperature High Pressure, respectively obtain the Lignum Aquilariae Resinatum tetrol that skims the cream off milk of Lignum Aquilariae Resinatum, and Lentinus Edodess
The fungus polysaccharide that skims the cream off milk, mix；
2), add other raw materials of powder, mix, obtain final product.
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| CN116617316A (en) * | 2023-07-12 | 2023-08-22 | 广东省科学院动物研究所 | Application of agilawood essential oil in preparation of medicine for treating nasopharyngeal carcinoma |
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| CN101485830A (en) * | 2009-02-19 | 2009-07-22 | 宋小冰 | Pure Chinese medicine anti-aging health-care capsule |
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| CN1544032A (en) * | 2003-11-21 | 2004-11-10 | 李文军 | Anticancer Chinese traditional extracts and preparation process and application thereof |
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| CN101485830A (en) * | 2009-02-19 | 2009-07-22 | 宋小冰 | Pure Chinese medicine anti-aging health-care capsule |
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Application publication date: 20170222 |