CN104274808A - Traditional Chinese medicine composition for anti-altitude stress - Google Patents
Traditional Chinese medicine composition for anti-altitude stress Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The present invention relates to the technical field of Chinese herbal medicines and particularly relates to a traditional Chinese medicine composition for anti-altitude stress. The traditional Chinese medicine composition is composed of 10-38 parts of Tibetan coriander root, 10-40 parts of rhodiola crenulata, 5-10 parts of hippophae tibetana, 8-28 parts of longan seed, 12-26 parts of Chinese waxgourd peel, 5-15 parts of pseudo-ginseng and 5-13 parts of dried ginger; and the composition provided by the invention can effectively alleviate such symptoms caused by altitude stress as headache, loss of appetite, fatigue, weakness, dizziness and the like, and provides a new choice for clinically preventing and treating altitude stress and alleviating a variety of symptoms caused by altitude stress.
Description
Technical field
The present invention relates to Chinese crude drug technical field, specifically a kind of Chinese medicine composition with altitude sickness prevention.
Background technology
Altitude sickness and acute high altitude sickness (acute high altitude disease, AHAD), after people arrives certain height above sea level, health is that the draught head, the oxygen content that adapt to cause because of height above sea level are few, the change of air drying etc., and the natural physiological reaction produced, when height above sea level generally reaches about 2700 meters, just have altitude sickness.Main manifestations is, show as headache, nervous, tachypnea, loss of appetite, asthenia, weak, dizzy, Nausea and vomiting, abdominal distention, diarrhoea, pain uncomfortable in chest, insomnia, dim eyesight, drowsiness, dizzy, numb hand and foot, tic etc., sign is increased heart rate, exaggerated respiration, blood pressure mile abnormality, face or edema of the limbs, die Blausucht etc.
Therefore, develop medicine, health product or the functional food with resisting oxygen lack, this seems particularly important.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of altitude sickness prevention.Said composition can alleviate headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, Be very effective.
For achieving the above object, the technical solution used in the present invention is: a kind of Chinese medicine composition of altitude sickness prevention, is made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 10 ~ 38 parts, Radix Rhodiolae 10 ~ 40 parts, Fructus Hippophae thibetanae 5 ~ 10 parts, seed of Arillus Longan 8 ~ 28 parts, Exocarpium Benincasae 12 ~ 26 parts, Radix Notoginseng 5 ~ 15 parts and Rhizoma Zingiberis 5 ~ 13 parts.
Further, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 15 ~ 35 parts, Radix Rhodiolae 13 ~ 35 parts, Fructus Hippophae thibetanae 6 ~ 8 parts, seed of Arillus Longan 10 ~ 25 parts, Exocarpium Benincasae 15 ~ 23 parts, Radix Notoginseng 7 ~ 12 parts and Rhizoma Zingiberis 6 ~ 11 parts.
Further, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 30 parts, Radix Rhodiolae 35 parts, Fructus Hippophae thibetanae 7 parts, seed of Arillus Longan 18 parts, Exocarpium Benincasae 19 parts, Radix Notoginseng 9 parts and Rhizoma Zingiberis 8 parts.
The preparation method of the Chinese medicine composition of altitude sickness prevention of the present invention, step comprises:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoction 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then presses 6 times of water yields, decocts 1.5h repetition 7 ~ 10 times, merging filtrate;
(2) filtrate 0.08MPa, be evaporated to 70 DEG C at 70 DEG C time relative density be 1.15, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stir, hold over night, filters, and filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, extractum is put in stainless steel disc, less than 60 DEG C vacuum dryings become dry cream, pulverize, obtain Chinese medicine composition extract.
Using method of the present invention, Chinese medicine composition is pharmaceutical preparation, and pharmaceutical preparation comprises oral liquid, granule, tablet, capsule.In addition the present invention drinks after caning be passed through and decocting.
In the present invention, Tibet Radix Brassicae Rapae (Brassica rapa Linn.) has another name called turnip, circle root (Tibet common name), is called " mother girl ", is the distinctive food in high altitude localities, medicine, raises three and use plant in Tibetan language.Tibet Radix Brassicae Rapae rich in proteins, crude fibre, calcium, phosphorus, ferrum and vitamin etc. more than 20 plant the nutritional labeling of needed by human body, what is more important Tibet yuenkanin extract has resisting oxygen lack and can improve body blood coefficient of oxygen utilization with medicine, increase blood confession, Promote immunity, thus it is relevant to improve body anaerobic condition.
The fruit of Fructus Hippophae thibetanae (Hippophaethibetana) has blood circulation promoting and blood stasis dispelling, YIN nourishing, the kidney invigorating, the giddy of the chest stuffiness relieving anti-initiation on deficiency of liver-blood, liver-yang, tinnitus, by the effect regulating liver blood function to play resisting fatigue.
Radix Rhodiolae (Rhodiola crenulata) is the medicine food dual purpose plant that the Tibetan common people commonly use, and primary growth is in the severe cold of Tibet plateau more than height above sea level 4500m, anoxia, strong sunshine, pollution-free area.There is heart tonifying, diastole cardiovascular and cerebrovascular vessel, oxygenating effect, contribute to purifying blood, remove refuse in blood, improve immunity and anti-fatigue ability.Also can activate cells in vivo simultaneously, improve cerebral tissue causes anoxia tolerance to fatigue, the resistance of strengthening cardiac muscle to anoxia, regulates blood pressure, makes internal body reach balance.
Advantageous Effects of the present invention is: compositions of the present invention effectively can alleviate headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, for clinical prevention treatment altitude sickness disease, the individual various symptom that alleviation altitude sickness causes provides a kind of new selection.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A Chinese medicine composition for altitude sickness prevention, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 30 parts, Radix Rhodiolae 35 parts, Fructus Hippophae thibetanae 7 parts, seed of Arillus Longan 18 parts, Exocarpium Benincasae 19 parts, Radix Notoginseng 9 parts and Rhizoma Zingiberis 8 parts.
Preparation method step comprises:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoct 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then repeats 10 times, merging filtrate by 6 times of water yields, decoction 1.5h;
(2) by filtrate, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stirs, hold over night, filter, filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, and extractum is put in stainless steel disc, and less than 60 DEG C vacuum dryings become dry cream, pulverize, obtain Chinese medicine composition extract.
Extract uses after making tablet.
Embodiment 2
A Chinese medicine composition for altitude sickness prevention, is made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 15 parts, Radix Rhodiolae 35 parts, Fructus Hippophae thibetanae 8 parts, seed of Arillus Longan 10 parts, Exocarpium Benincasae 23 parts, Radix Notoginseng 7 parts and Rhizoma Zingiberis 11 parts.
Preparation method step comprises:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoct 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then repeats 7 times, merging filtrate by 6 times of water yields, decoction 1.5h;
(2) by filtrate, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stirs, hold over night, filter, filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, and extractum is put in stainless steel disc, and less than 60 DEG C vacuum dryings become dry cream, pulverize, obtain Chinese medicine composition extract.
Extract is edible after making granule.
Embodiment 3
A Chinese medicine composition for altitude sickness prevention, is characterized in that, is made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 38 parts, Radix Rhodiolae 10 parts, Fructus Hippophae thibetanae 10 parts, seed of Arillus Longan 8 parts, Exocarpium Benincasae 26 parts, Radix Notoginseng 15 parts and Rhizoma Zingiberis 5 parts.
Preparation method is:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoct 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then repeats 8 times, merging filtrate by 6 times of water yields, decoction 1.5h;
(2) by filtrate, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stirs, hold over night, filter, filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, and extractum is put in stainless steel disc, and less than 60 DEG C vacuum dryings become dry cream, pulverize, get product.
Extract is edible after making capsule.
Embodiment 4
A Chinese medicine composition for altitude sickness prevention, is characterized in that, is made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 10 parts, Radix Rhodiolae 40 parts, Fructus Hippophae thibetanae 5 parts, Arillus Longan 28 parts, Exocarpium Benincasae 12 parts, Radix Notoginseng 15 parts and Rhizoma Zingiberis 5 parts.
Preparation method is:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoct 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then repeats 9 times, merging filtrate by 6 times of water yields, decoction 1.5h;
(2) by filtrate, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stirs, hold over night, filter, filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, and extractum is put in stainless steel disc, and less than 60 DEG C vacuum dryings become dry cream, pulverize, get product.
Extract is edible after making pill.
Embodiment 5
A Chinese medicine composition for altitude sickness prevention, is characterized in that, is made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 15 parts, Radix Rhodiolae 35 parts, Fructus Hippophae thibetanae 6 parts, seed of Arillus Longan 25 parts, Exocarpium Benincasae 15 parts, Radix Notoginseng 7 parts and Rhizoma Zingiberis 11 parts.
Preparation method is: mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decocts 2h, then second time adds the water of medicine gross weight 6 times, decoct 1.5h, then repeat 9 times by 6 times of water yields, decoction 1.5h, each decoction after medicinal liquid cools directly is drunk.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. the Chinese medicine composition of an altitude sickness prevention, it is characterized in that, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 10 ~ 38 parts, Radix Rhodiolae 10 ~ 40 parts, Fructus Hippophae thibetanae 5 ~ 10 parts, seed of Arillus Longan 8 ~ 28 parts, Exocarpium Benincasae 12 ~ 26 parts, Radix Notoginseng 5 ~ 15 parts and Rhizoma Zingiberis 5 ~ 13 parts.
2. the Chinese medicine composition of altitude sickness prevention according to claim 1, it is characterized in that, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 15 ~ 35 parts, Radix Rhodiolae 13 ~ 35 parts, Fructus Hippophae thibetanae 6 ~ 8 parts, seed of Arillus Longan 10 ~ 25 parts, Exocarpium Benincasae 15 ~ 23 parts, Radix Notoginseng 7 ~ 12 parts and Rhizoma Zingiberis 6 ~ 11 parts.
3. the Chinese medicine composition of altitude sickness prevention according to claim 2, it is characterized in that, be made up of the raw material of following parts by weight: Tibet Radix Brassicae Rapae 30 parts, Radix Rhodiolae 35 parts, Fructus Hippophae thibetanae 7 parts, seed of Arillus Longan 18 parts, Exocarpium Benincasae 19 parts, Radix Notoginseng 9 parts and Rhizoma Zingiberis 8 parts.
4. the preparation method of the Chinese medicine composition of altitude sickness prevention according to any one of claims 1 to 3, it is characterized in that, step comprises:
(1) mix after being weighed by weight by each raw material, then add the water of medicine gross weight 8 times, decoction 2h, then second time adds the water of medicine gross weight 6 times, decocts 1.5h, then presses 6 times of water yields, decocts 1.5h repetition 7 ~ 8 times, merging filtrate;
(2) by filtrate, 0.08MPa, relative density is 1.15 when being evaporated to 70 DEG C at 70 DEG C, adding 95% (v/v) ethanol makes alcohol content reach 85% (v/v), stirs, hold over night, filter, filtrate concentrating under reduced pressure one-tenth under 0.08MPa, 65 DEG C of conditions is the extractum of 1.15g/mL to relative density when 65 DEG C, and extractum is put in stainless steel disc, and less than 60 DEG C vacuum dryings become dry cream, pulverize, obtain Chinese medicine composition extract.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168308A (en) * | 2015-09-09 | 2015-12-23 | 白玛仁增 | Altitude sickness-resistant compound Tibetan medicine preparation |
| CN109718254A (en) * | 2019-01-16 | 2019-05-07 | 中国人民解放军总医院 | The bacillus gram that quivers, which belongs to, is preventing or is treating the application in the medicine of plateau |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100136146A1 (en) * | 2003-07-31 | 2010-06-03 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
| CN102178756A (en) * | 2011-04-21 | 2011-09-14 | 西藏屋脊之宝食品有限公司 | Oral liquid for treating high altitude disease (HAD) and preparation method thereof |
| CN103948896A (en) * | 2014-05-13 | 2014-07-30 | 于法周 | Composition for resisting altitude stress and application of composition |
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2014
- 2014-10-11 CN CN201410531879.2A patent/CN104274808A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100136146A1 (en) * | 2003-07-31 | 2010-06-03 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
| CN102178756A (en) * | 2011-04-21 | 2011-09-14 | 西藏屋脊之宝食品有限公司 | Oral liquid for treating high altitude disease (HAD) and preparation method thereof |
| CN103948896A (en) * | 2014-05-13 | 2014-07-30 | 于法周 | Composition for resisting altitude stress and application of composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168308A (en) * | 2015-09-09 | 2015-12-23 | 白玛仁增 | Altitude sickness-resistant compound Tibetan medicine preparation |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
| CN109718254A (en) * | 2019-01-16 | 2019-05-07 | 中国人民解放军总医院 | The bacillus gram that quivers, which belongs to, is preventing or is treating the application in the medicine of plateau |
| CN109718254B (en) * | 2019-01-16 | 2021-11-26 | 中国人民解放军总医院 | Application of oscillatoria in preparation of drugs for preventing or treating altitude diseases |
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Application publication date: 20150114 |