CN103948896A - Composition for resisting altitude stress and application of composition - Google Patents
Composition for resisting altitude stress and application of composition Download PDFInfo
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- CN103948896A CN103948896A CN201410199869.3A CN201410199869A CN103948896A CN 103948896 A CN103948896 A CN 103948896A CN 201410199869 A CN201410199869 A CN 201410199869A CN 103948896 A CN103948896 A CN 103948896A
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Abstract
The invention relates to a composition for resisting altitude stress and application of the composition. The composition comprises traditional Chinese medicinal extracts, wherein the traditional Chinese medicinal extracts are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 50-80 parts of longan seed, 40-52 parts of exocarpium benincasae, 15-25 parts of pseudo-ginseng and 15-25 parts of dried ginger. The composition can be used for effectively relieving headache, anorexia, lassitude, weakness, dizziness and other symptoms caused by altitude stress, and provides a novel choice for clinically preventing and treating altitude stress, and relieving each syndrome caused by the altitude stress.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of compositions and application thereof of altitude sickness prevention.
Background technology
Altitude sickness, it is altitude sickness, finger enters rapidly 3000 meters of above highlandss without the people of adaptive training, because partial pressure of oxygen in atmospheric pressure reduces, body reduces low-oxygen environment toleration, be difficult to adaptation and cause anoxia, cause thus a series of altitude maladjustment, show as headache, nervous, tachypnea, loss of appetite, asthenia, weak, dizzy, feel sick, vomiting, abdominal distention, diarrhoea, pain uncomfortable in chest, insomnia, dim eyesight, drowsiness, dizzy, numb hand and foot, twitch etc., sign is that heart rate is accelerated, exaggerated respiration, blood pressure mile abnormality, face or edema of the limbs, die Blausucht etc.Therefore, develop medicine, health product or the functional food with resisting oxygen lack, this seems particularly important.
At present, also there is natural drug to be used in conjunction with the report for the treatment of and prevention altitude sickness, but there are no seed of Arillus Longan, Exocarpium Benincasae, Radix Notoginseng and Rhizoma Zingiberis compatibility, use the report of rear treatment and prevention altitude sickness.
Summary of the invention
The object of the present invention is to provide a kind of compositions and application thereof of altitude sickness prevention.Said composition can be alleviated headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, and effect is remarkable.
The object of the present invention is achieved like this:
A kind of compositions of altitude sickness prevention, said composition contains Chinese medicine extract, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: seed of Arillus Longan 50-80 part, Exocarpium Benincasae 40-52 part, Radix Notoginseng 15-25 part, Rhizoma Zingiberis 15-25 part.
Preferably, the compositions of altitude sickness prevention as above, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: seed of Arillus Longan 58-65 part, Exocarpium Benincasae 45-46 part, Radix Notoginseng 19-21 part, Rhizoma Zingiberis 19-21 part.
Further preferably, the compositions of altitude sickness prevention as above, by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 60 parts of seed of Arillus Longan, 45 parts of Exocarpium Benincasaes, 20 parts of Radix Notoginseng, 20 parts of Rhizoma Zingiberiss.
It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: seed of Arillus Longan is selected the dry seed of Sapindaceae Euphoria plant Arillus Longan Dimocarpus longan Lour..Exocarpium Benincasae is selected the outer peel of cucurbitaceous plant Fructus Benincasae.Radix Notoginseng is selected the dry root of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen.Rhizoma Zingiberis is selected the dry rhizome of zingiber Zingiber officinale Rosc..
Again further preferably, the compositions of altitude sickness prevention as above, wherein said compositions is pharmaceutical preparation, described pharmaceutical preparation comprises oral liquid, granule, tablet, capsule.
The Chinese medicine extract the present invention relates to is prepared as follows and obtains: take seed of Arillus Longan 50-80 part, Exocarpium Benincasae 40-52 part, Radix Notoginseng 15-25 part, Rhizoma Zingiberis 15-25 part merges, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 2h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃ under 65 ℃ of conditions, relative density is 1.15g/mL, extractum is put in stainless steel disc, 60 ℃ of following vacuum dryings become dry cream, pulverize, obtain Chinese medicine extract.
The pharmaceutical preparation the present invention relates to can make according to general preparation method, such as the preparation method of granule can be, takes after above-mentioned Chinese medicine extract, adds the cane sugar powder of 4 times of amounts, dry granulation, packing, every bag 20g.Within 2-4 days before entering plateau, start to take this granule, every day 2 times sooner or later, each 1 bag.
Inventor finds by the experimental study of mice airtight anoxia, above-mentioned Chinese medicine extract can extend the time-to-live of mice under airtight anoxia condition and total oxygen consumption, therefore another object of the present invention is to provide a kind of pharmaceutical applications, that is: the application of above-mentioned Chinese medicine extract in preparing the medicine of anoxia enduring, health product and food.
Compositions of the present invention can effectively be alleviated headache that altitude sickness disease causes, loss of appetite, asthenia, the symptom such as weak, dizzy, is clinical prevention treatment altitude sickness disease, and alleviating the individual various symptoms that altitude sickness causes provides a kind of new selection.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine granules
Take seed of Arillus Longan 0.60kg, Exocarpium Benincasae 0.45kg, Radix Notoginseng 0.20kg and Rhizoma Zingiberis 0.20kg merge, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 2h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃ under 65 ℃ of conditions, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dry cream, pulverize, the cane sugar powder that adds 4 times of amounts, dry granulation, packing, every bag 20g.
The preparation of embodiment 2 Chinese medicine oral liquid
Take seed of Arillus Longan 0.65kg, Exocarpium Benincasae 0.52kg, Radix Notoginseng 0.20kg and Rhizoma Zingiberis 0.25kg, clean roguing, dry, mix, be ground into bulky grain; Again above-mentioned graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water 2 times in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material, decoct 1.5h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.25; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration, stirs containing 4-5g crude drug amount to every milliliter, sets to 0-5 ℃ of deepfreeze 24h, and cold preservation liquid is filtered, and obtains oral liquid.
The preparation of embodiment 3 Chinese medicine oral liquid
Take seed of Arillus Longan 0.50kg, Exocarpium Benincasae 0.40kg, Radix Notoginseng 0.25kg and Rhizoma Zingiberis 0.15kg merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.20, adding 95% (v/v) ethanol makes to reach 80% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.15g/mL, add water and sucrose is mixed with oral liquid.
The animal experiment of embodiment 4 Chinese medicine extract anti-hypoxia
The preparation of Chinese medicine dried cream powder sample: take seed of Arillus Longan 60g, Exocarpium Benincasae 45g, Radix Notoginseng 20g and Rhizoma Zingiberis 20g merge, decoct with water twice, adding for the first time water is 8 times of amounts of medical material weight, decoct 2h, adding for the second time water is 6 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃ under 65 ℃ of conditions, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dry cream, pulverize, obtain.
2 36 of monthly age kunming mices, male and female half and half, body weight 25g left and right.Mice adaptability was raised after one week, was divided at random following three groups: Chinese medicine is low, high dose group and negative control group, 12 every group.Take Mouse Weight as benchmark, Chinese medicine is low, high dose group respectively single dose gavage give Chinese medicine dried cream powder 2.4g/ (kgd), the 4.8g/ (kgd) of above-mentioned preparation, negative control group gavage gives isopyknic distilled water, is sooner or later respectively administered once, continuously gavage 7d.After last administration 40min, each is organized mice and puts into respectively toy lower oxygen concentration resistance and oxygen consumption dynamic change synchronous measurement device, with vaseline, smears bottleneck, cover tightly, timing immediately, and record the oxygen consumption in every 5min, until respiratory arrest records mouse survival time and total oxygen consumption.Take mice time-to-live and total oxygen consumption in airtight wide mouthed bottle is index, respectively organizes mice hypoxia-bearing capability.
Result of the test by table 1 can be found out, the Chinese medicine extract of various dose can extend the time-to-live of mice under airtight anoxia condition and total oxygen consumption, and increase with the total oxygen consumption of increase mice of dosage and time-to-live, with negative control group comparing difference have statistical significance (
p< 0.05 or
p< 0.01).
Table 1 is respectively organized mice airtight anoxia time-to-live and total oxygen consumption comparison
| Group | n | Total oxygen consumption (mL) | Time-to-live (min) |
| Negative control group | 12 | 21.82±5.09 | 20.94±8.15 |
| Chinese medicine low dose group | 12 | ?23.67±4.10* | ?29.93±9.38* |
| Chinese medicine high dose group | 12 | 25.04±5.61* | ?41.82±11.42** |
With negative control group comparison,
* p< 0.05,
* p< 0.01.
Claims (5)
1. the compositions of an altitude sickness prevention, said composition contains Chinese medicine extract, it is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: seed of Arillus Longan 50-80 part, Exocarpium Benincasae 40-52 part, Radix Notoginseng 15-25 part, Rhizoma Zingiberis 15-25 part.
2. the compositions of altitude sickness prevention according to claim 1, it is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: seed of Arillus Longan 58-65 part, Exocarpium Benincasae 45-46 part, Radix Notoginseng 19-21 part, Rhizoma Zingiberis 19-21 part.
3. the compositions of altitude sickness prevention according to claim 2, is characterized in that: by weight, described Chinese medicine extract is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 60 parts of seed of Arillus Longan, 45 parts of Exocarpium Benincasaes, 20 parts of Radix Notoginseng, 20 parts of Rhizoma Zingiberiss.
4. according to the compositions of the altitude sickness prevention described in claim 1 or 2 or 3, it is characterized in that: described compositions is pharmaceutical preparation, described pharmaceutical preparation comprises oral liquid, granule, tablet, capsule.
5. the application of the Chinese medicine extract described in claim 1 or 2 or 3 in preparing the medicine of anoxia enduring, health product and food.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410199869.3A CN103948896A (en) | 2014-05-13 | 2014-05-13 | Composition for resisting altitude stress and application of composition |
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| CN201410199869.3A CN103948896A (en) | 2014-05-13 | 2014-05-13 | Composition for resisting altitude stress and application of composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274808A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Traditional Chinese medicine composition for anti-altitude stress |
| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053396A (en) * | 2007-03-06 | 2007-10-17 | 屈跃曾 | Altitude sickness prevention food composition and its preparation method |
| CN101279049A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Soft capsules for resisting altitude stress |
-
2014
- 2014-05-13 CN CN201410199869.3A patent/CN103948896A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053396A (en) * | 2007-03-06 | 2007-10-17 | 屈跃曾 | Altitude sickness prevention food composition and its preparation method |
| CN101279049A (en) * | 2007-04-06 | 2008-10-08 | 王洪飞 | Soft capsules for resisting altitude stress |
Non-Patent Citations (3)
| Title |
|---|
| 张晓君等: "中西药结合防治儿童过敏性鼻炎34例", 《中国医药指南》 * |
| 杜朝辉等: "抗运动性疲劳中药研究现状", 《中国运动医学杂志》 * |
| 胡婷婷等: "桂圆核对小鼠疲劳与缺氧应激的影响", 《齐齐哈尔医学院学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274808A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Traditional Chinese medicine composition for anti-altitude stress |
| WO2020062912A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical application of pyrimidine sulfonamides derivatives |
| WO2020062913A1 (en) | 2018-09-25 | 2020-04-02 | 中国人民解放军总医院 | Medical use of prostacyclin receptor agonist |
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Application publication date: 20140730 |