CN101279049A - Soft capsules for resisting altitude stress - Google Patents

Soft capsules for resisting altitude stress Download PDF

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CN101279049A
CN101279049A CNA2007100907447A CN200710090744A CN101279049A CN 101279049 A CN101279049 A CN 101279049A CN A2007100907447 A CNA2007100907447 A CN A2007100907447A CN 200710090744 A CN200710090744 A CN 200710090744A CN 101279049 A CN101279049 A CN 101279049A
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percentage
weight
soft capsule
oil
altitude sickness
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王洪飞
李强
宋旭波
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Abstract

The invention relates to a soft capsule for resisting altitude sickness, which pertains to the technical field of nutrient and health caring food. The technical proposal of the invention is characterized in that: the contents of the soft capsule for resisting altitude sickness consist of vegetable oil, spirulina and a suspending agent based on a certain proportion, wherein, the weight percentage of the vegetable oil is 95 percent to 5 percent, the weight percentage of the spirulina is 4.5 percent to 85 percent and the weight percentage of the suspending agent is 0.5 percent to 10 percent. The soft capsule aims at providing a nutrient and health caring food that can effectively prevent and alleviate altitude sickness and is convenient to take, easy to bring and safe without any toxicity.

Description

A kind of soft capsule of altitude sickness prevention
Technical field
The present invention relates to a kind of altitude sickness prevention soft capsule, belong to nutrition, health food technology field.
Background technology
Elevation is called the highlands in the area more than 3000 meters, and its characteristics are that air pressure is low, and the concentration of oxygen is also low in the air, easily causes human body anoxia, causes that altitude sickness comprises acute high altitude reaction, plateau pneumochysis, high altitude cerebral adema etc.Enter reactions such as the plateau all can produce headache, giddy, cardiopalmus more than 3000 meters, breathe hard in short time, weight person also has loss of appetite, feels sick, vomiting, insomnia, tired, abdominal distention and uncomfortable in chest.After being entered the plateau or entered more the high altitude localities by the plateau by the Plain, a series of anoxias performances that body took place in short-term are called acute high altitude reaction.Acute high altitude reaction mainly betides immigrant.Environment of low oxygen plateau causes the body anoxia, is the main cause that acute high altitude reaction takes place, and scientist discovers that the atmospheric variation in plateau also is the major reason that causes altitude sickness in recent years.The rapid variation of anoxia and atmospheric pressure environment all has certain influence to the nervous system of human body, respiratory system, cardiovascular system, digestive system etc., thereby a series of corresponding symptoms take place.In addition, the oxygen consumption of body itself increases, and as factors such as psychentonia, overtired, upper respiratory tract infection, can further add the supply-demand imbalance of heavy oxygen, brings out the generation of acute high altitude reaction or aggravates disease.
Acute high altitude reaction is a kind of irritability reaction of body to altitude environment, and the various functions that are body are by the neurohumoral clinical symptoms that is presented in the equilibrium process that reaches new on the new basis that is adjusted in.Some people can not reach balance all the time by long-term continual adjustment process on new basis, so that forms the phenomenon of a kind of plateau dysfunction, presents a series of clinical symptoms, and this situation promptly is called chronic mountain reaction.Chronic mountain reaction is called " body dysfunction " again.Chronic mountain reaction is characterized in that clinical manifestation is varied, can serve as main performance with the symptom of a system, also can occur the symptom of several systems simultaneously; Symptom is flickering, but after returning flat low altitude area, symptom generally can disappear; Overwhelming majority patient can adhere to normal work and life on the plateau.Because the clinical manifestation of chronic mountain reaction and acute high altitude reaction has more similarity, in order to distinguish, all plateaus that enters still had part or all of altitude sickness symptom after three months, can be considered chronic mountain reaction.
Compare with China most of area, the rarefaction of air in Tibet, sunshine abundance, temperature is lower, difference variation is big.Proverbs such as " ten li are not on the same day ", " one day have the four seasons " have promptly reflected these characteristics.Only oxygenous about 150-170 restrains in the every cubic metres of air of Tibet plateau, is equivalent to the 62%-65.4% of plains region.The temperature of Tibet plateau is on the low side, and day and night temperature is big, and the average temperature of the whole year in Lhasa, Rikaze and the hottest month temperature hang down 10-15 degree centigrade than Chongqing, Wuhan, the Shanghai of close latitude.The Qinghai-Tibet Platean is from the east of REGIONALIZATION OF THE HENGDUAN MOUNTAINOUS REGION, and noise made in coughing or vomiting loudspeaker the Kunlun is supported in the west, reaches Himalaya in the south, and north reaches Altun-northern foot, the Qilian mountains.Because physical features is loud and sonorous, rarefaction of air, weather cold have formed the plateau climate that shows unique characteristics.Particularly aspect Temperature Distribution and heat condition, very big-difference is arranged with the eastern region.Warm season Wen Liang, the hottest month temperature are not high.Qinghai-Tibet Platean various places the hottest monthly mean temperature is lower than 25 ℃, and the most extreme lowest temperature in hot month is also many below 0 ℃, and frost all may take place in any month, does not have absolute frost-free period substantially.
Flourish along with Tibet, Qinghai-Tibet, Yunnan Lijing tourist industry, large quantities of visitors enter the highlands and go sightseeing, but altitude sickness is a very important problem, it not only may bring the discomfort of health to the traveller, and can not allow the traveller loosen mood, so the indulge in luxuriousness to one's heart's desire beautiful scenery of the Nature is prevention and improve altitude sickness and become an important problems.The Chinese patent of application number 97116426.6 discloses oral liquid of a kind of altitude sickness prevention and preparation method thereof, but this oral liquid prescription adopts 25 flavor Chinese medicines, and dose is difficult to determine, and is unfavorable for suitability for industrialized production, uses to have certain limitation.
Summary of the invention
For addressing the above problem, the object of the invention is to provide a kind of effective prevention and improves altitude sickness, and taking convenience is easy to carry about with one, the safety non-toxic nutritional health food.
For achieving the above object, the invention provides a kind of soft capsule of altitude sickness prevention, the content of soft capsule is made of by a certain percentage vegetable oil, spirulina and suspending agent, wherein the percentage by weight of vegetable oil is 95%-5%, the percentage by weight of spirulina is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.The vegetable oil of preparation in the soft capsule is by in Princepia utilis oil, Camellia oil, olive oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil one or several.
Content by above-mentioned preparation altitude sickness prevention soft capsule is by Princepia utilis oil percentage by weight 95%-5%, and the percentage by weight of spirulina is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
For strengthening soft capsule altitude sickness prevention effect; can add following anti-hypoxia; resisting fatigue; improve the material of immunity; collaborative performance effect; comprise Fructus Lycii; Fructus Mori; Radix Puerariae; Poria; Semen Ziziphi Spinosae; Rhizoma Dioscoreae; Radix Rhodiolae; Folium Ginkgo; Radix Ginseng; Radix Panacis Quinquefolii; Ganoderma; Herb Gynostemmae Pentaphylli; Radix Et Caulis Acanthopanacis Senticosi; green tea; Fructus Jujubae; Herba Houttuyniae; tea polyphenols; the Radix Astragali; Fructus Crataegi; pollen; Herba Cistanches; Semen Vitis viniferae extract; soybean phospholipid; Margarita powder; Colla Corii Asini; Lac regis apis; propolis; Squalene; Formica fusca; Cordyceps; the armillaria mellea extract; cattle colostrums; taurine; nucleic acid; melatonin; vitamin E; chitosan; the Sargassum polysaccharides sulfuric ester; in 1,6 fructose diphosphate one or several.
Spirulina is the thread algae of a kind of aeruginous, belongs to Cyanophyta beads Cutleriales Oscillariaceae Spirullina, is made of single mycelia, in the shape of a spiral shape.Rich in proteins 58%~72%, higher 3~3.5 times than high-protein foods such as beef, eggs, and contain gamma-Linolenic acid, potassium, phosphorus, ferrum, zinc and various vitamin.The effect of mainly have resisting fatigue, anoxia enduring, radioprotective, blood lipid regulation, enhance metabolism, enhance immunity being regulated.
Princepia utilis has another name called Folium Prinsepiae Utilis, the fruit of buying oil, and is this plant of Rosaceae Folium Prinsepiae Utilis, mainly is grown in mountain region, the barren hill of 1800~3200 meters in cloud, expensive, valley district height above sea level, belongs to the woody oleiferous plants crop of a kind of " happiness is cool " of high and cold mountain area.Princepia utilis oil is rich in fatty acid and fat-soluble A, D, E, K and the various trace elements of multiple needed by human, is described as " eatable cosmetics " and " human body replenishes the new source of essential fatty acid " by nutritionist.
Olive oil is the pure natural fruit oil juice that the Fructus oleae europaeae fruit obtains by the physics cold pressing process after artificial the harvesting in a short period of time.Be rich in various antioxidant vitamin Es in the olive oil, carotenoid and phenolic compound, abundant trace element Squalene, Flavonoid substances, can strengthen the immunity of human body, slow down aging, these materials are being eliminated free radical and some and chronic disease and the relevant molecule of aging, and aspect such as life-saving all plays a part positive.
Fructus Lycii is the fruit of Solanaceae machaka, and is orange red to kermesinus, big with the lycium barbarum fruit, and matter is good to be celebrated.Mainly contain carotenoid, betanin, Fructus Lycii oil and multivitamin etc.Fructus Lycii has the function of immunomodulating, slow down aging, resisting fatigue, mutation, and the non-characteristic immunostimulant of lycium barbarum polysaccharide wherein improves body's immunological function, strengthens resistance against diseases, to reach defying age, antitumor, radioprotective, antiviral effect.
Radix Puerariae is a kind of tuber of medicine food dual purpose plant of pulse family Pueraria lobota genus, mainly contains Radix Puerariae total flavones, Radix Puerariae saponin, triterpenoid compound, alkaloid etc.Radix Puerariae has resisting fatigue, and anoxia enduring improves the blood flow of cardiovascular and cerebrovascular vessel, improves the blood vessel microcirculation disturbance, the effect that brings high blood pressure down.
Semen Ziziphi Spinosae is the seed of Rhamnaceae arbor Ziziphi Spinosae mature fruit, dries to form, and mainly contains jujuboside, betulic acid, betulin etc.Have good improvement sleep, resisting oxygen lack has slow down aging, arrhythmia simultaneously, and the blood lipid regulation effect can be used for restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body etc.
Green tea extract mainly contains tea polyphenols, the major physiological activity is effects such as slow down aging, resisting fatigue, auxiliary inhibition tumor, caries prevention, its oxidation resistance is stronger 18 times than vitamin E, all has clear and definite effect for arteriosclerosis, the inhibition carcinogen of eliminating intravital free radical, prevent the LDL oxidation effect to be caused.
Radix Rhodiolae is a Crassulaceae rhodiola herbaceos perennial, mainly is born in Qinghai-Tibet Platean and the northeast Changbaishan area of height above sea level more than 1700 meters.The traditional Chinese medical science is thought its QI invigorating tonify deficiency, and strengthening the body resistance is by " in the book on Chinese herbal medicine top grade ".Radix Rhodiolae contains rhodioside, flavone, nucleic acid, superoxide dismutase etc., has anoxia enduring, resisting fatigue, immunomodulating, cold-resistant and resistant to elevated temperatures effect.
Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is the ancient seeds of China, and it is the tree of the medical treatment of mystery, is called as on the organic evolution history " living fossil ".Folium Ginkgo can blood circulation promoting, and the prevention cardiovascular diseases has very strong removing free radical and antioxidation, and the extract of Folium Ginkgo is treatment cardiovascular disease and defying age, dementia specific drug.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii, all is the cultivation product.Radix Panacis Quinquefolii contains the ginsenoside, and as ginsenoside Ro, Rb1, Rb2, Rc, Rd, Re, Rg1 and Panax pseudoginseng Wall. saponin, in addition, Radix Panacis Quinquefolii also contains 18 seed amino acids such as arginine, aspartic acid.Radix Panacis Quinquefolii has effects such as anti-hypoxia, resisting fatigue, defying age, anticancer, immune two-ways regulation.
The present invention is according to the influence of geographical conditions such as the geography and climate of highlands, environment, temperature, atmospheric pressure, ultraviolet radiation to human body physiological function, add material with anoxia enduring, resisting fatigue, raising immunity, after effectively prevention and improvement enter the highlands, because of the rapid variation of anoxia and atmospheric pressure environment influence, has very big value for entering highlands work and tourism crowd to the nervous system of human body, respiratory system, cardiovascular system, digestive system.
The specific embodiment
Below in conjunction with specific embodiment altitude sickness prevention soft capsule provided by the invention is specifically described, but the invention is not restricted to embodiment described below.
Embodiment 1: a kind of soft capsule of altitude sickness prevention, it is Princepia utilis oil percentage by weight 75% that its content is formed, spirulina percentage by weight 20%, Cera Flava percentage by weight 5%.
Preparation technology: Cera Flava is heated to fusion, mixes with other component in the prescription, the powerful stirring 15 minutes makes its mix homogeneously, and the degassing is pressed mill by colloid mill, forms uniform and stable liquid, and mixed liquor is standby after filtering.With gelatin: glycerol: water: antiseptic=1: 0.4: 1.05: offset plate is made in 0.001 ratio dissolving can adhesive tape, mixed liquor is placed between two blocks of offset plates again, regulates out the thickness and the uniformity of rubber, forming with the punching block compacting.Continuous production adopts rotation Zhanang machine automatically, article two, the adhesive tape made automatically of machine moves round about, arrive rotating mould before, the part combination of having pressurizeed, this moment, medicinal liquid entered between adhesive tape through conduit from filling pump, rotate into groove, the whole roll compacting combinations of back adhesive tape, the soft capsule of making, cooling is fixing earlier, the reuse washing with alcohol is deoiled, and is drying to obtain every heavily about 0.5g.
Embodiment 2: a kind of soft capsule of altitude sickness prevention, and it is Princepia utilis oil percentage by weight 95% that its content is formed, spirulina percentage by weight 3%, Cera Flava percentage by weight 2% is made soft capsule of the present invention, every heavily about 0.5g by the preparation technology of embodiment 1.
Embodiment 3: a kind of soft capsule of altitude sickness prevention, it is Princepia utilis oil percentage by weight 45% that its content is formed, olive oil percentage by weight 40%, spirulina percentage by weight 10%, Cera Flava percentage by weight 4%, vitamin E percentage by weight 1% is by the soft capsule that the preparation technology of embodiment 1 makes, every heavily about 0.5g.
Embodiment 4: a kind of soft capsule of altitude sickness prevention, it is olive oil percentage by weight 50% that its content is formed, Princepia utilis oil percentage by weight 30%, spirulina percentage by weight 10%, wolfberry fruit extract percentage by weight 5%, Cera Flava percentage by weight 5% is made soft capsule of the present invention, every heavily about 0.5g by the preparation technology of embodiment 1.
Embodiment 5: a kind of soft capsule of altitude sickness prevention, it is Princepia utilis oil percentage by weight 75% that its content is formed, spirulina percentage by weight 15%, green tea extract percentage by weight 5%, Cera Flava percentage by weight 5%, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Embodiment 6: a kind of soft capsule of altitude sickness prevention, it is soybean oil percentage by weight 40% that its content is formed, Princepia utilis oil percentage by weight 20%, spirulina percentage by weight 30%, Radix Puerariae percentage by weight 5%, Cera Flava percentage by weight 5% is made soft capsule of the present invention, every heavily about 0.5g by the preparation technology of embodiment 1.
Embodiment 7: a kind of soft capsule of altitude sickness prevention, its content is a Princepia utilis oil percentage by weight 55%, spirulina percentage by weight 30%, Radix Puerariae percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, soybean phospholipid percentage by weight 5%, present embodiment are suspending agent with the soybean phospholipid, preparation technology by embodiment 1 makes soft capsule of the present invention, every heavily about 0.5g.
Embodiment 8: a kind of soft capsule of altitude sickness prevention, it is olive oil percentage by weight 40% that its content is formed, Princepia utilis oil percentage by weight 10%, spirulina percentage by weight 20%, Radix Rhodiolae percentage by weight 10%, Folium Ginkgo percentage by weight 10%, Radix Panacis Quinquefolii percentage by weight 5%, Cera Flava percentage by weight 5% is made soft capsule of the present invention, every heavily about 0.5g by the preparation technology of embodiment 1.
Whether improving aspect the altitude sickness symptom effectively for investigating the altitude sickness prevention soft capsule, we have carried out anoxia enduring experiment under mice normal pressure, the reduced pressure, cold-resistant and high temperature resistant experiment, resisting fatigue experiment respectively.
1. altitude sickness prevention soft capsule condition of normal pressure anti-hypoxia experiment
Get 40 of mices, body weight 20~22g, male and female half and half are divided into 4 groups at random.The content of altitude sickness prevention soft capsule is taken out the back dilution, be mixed with high, medium and low dosage group.Normal saline is a matched group, irritate stomach give isometric(al) normal saline and the basic, normal, high dosage group of altitude sickness prevention soft capsule group (250,500,1000mg/kg).Gastric infusion is 20 days continuously, 1h after last is tried thing, each group mice is put into the 250ml wide mouthed bottle (putting 1 mice for every bottle) that fills the 15g sodica calx respectively, smear bottleneck with vaseline, cover completely, make it air tight, timing immediately, with the respiratory arrest is index, respectively organizes mice because anoxia and death time with stopwatch record, and experimental result sees Table 1
Table 1 altitude sickness prevention soft capsule is to the influence of mice condition of normal pressure hypoxia-bearing capability
Group Number of animals (only) Dosage (mg/kg) The anoxia time-to-live (min) The P value
Matched group 10 - 36.45±5.12 -
Low dose group 10 250 39.18±5.66 P>0.05
Middle dosage group 10 500 48.05±4.93 P<0.05
High dose group 10 1000 50.22±5.45 P<0.01
The experiment of altitude sickness prevention soft capsule normal pressure anti-hypoxia, after the mouse stomach administration, compare the middle dosage group energy significant prolongation anoxia in mice time-to-live with matched group, have significant difference (P<0.05), high dose group can significantly improve mice hypoxia-bearing capability (P<0.01) by the utmost point.Low dose group no significant difference (P>0.05).Show under the condition of normal pressure that the altitude sickness prevention soft capsule has obvious oxygen lack resistant function in range of doses.
2. the altitude sickness prevention soft capsule is tested the reduced pressure anti-hypoxia
Get 40 of mices, body weight 20~22g, male and female half and half, grouping and medication are the same.Continuously gastric infusion is 20 days, and 1h after last is tried thing places mice respectively in the vacuum drying oven, is decompressed to 21.328kPa with vacuum pump, and keep constant relatively, the record mouse diing time, experimental result sees Table 2
Table 2 altitude sickness prevention soft capsule is to the influence of mice reduced pressure hypoxia-bearing capability
Group Number of animals (only) Dosage (mg/kg) The anoxia time-to-live (min) The P value
Matched group 10 - 34.98±6.21 -
Low dose group 10 250 47.34±7.01 P<0.05
Middle dosage group 10 500 51.67±4.85 P<0.01
High dose group 10 1000 53.69±4.87 P<0.001
The experiment of altitude sickness prevention soft capsule decompression anti-hypoxia, the mouse stomach administration can obviously prolong the time-to-live of mice under the reduced pressure, and the basic, normal, high dosage group of altitude sickness prevention soft capsule and matched group comparing difference be (P<0.05 significantly, P<0.01, P<0.001).Show under the reduced pressure that the altitude sickness prevention soft capsule has obvious oxygen lack resistant function.
3. the cold-resistant and high temperature resistant experiment of altitude sickness prevention soft capsule
The mice of the same raising (male and female half and half), grouping and medication are the same.Successive administration 7 days, last administration are after 1 hour, with the single beaker of only putting into of mice, seal with gauze, place respectively in (15 ± 1) ℃ refrigerator, observe death condition once every 20min, or pairing places (45 ± 1) ℃ constant temperature oven, and the record time-to-live, experimental result sees Table 3 and table 4
Table 3 altitude sickness prevention soft capsule is to the influence of mice tolerance to cold
Group Number of animals (only) Dosage (mg/kg) The low temperature time-to-live (min) The P value
Matched group 10 - 118.25±10.27 -
Low dose group 10 250 125.14±11.28 P>0.05
Middle dosage group 10 500 166.18±15.85 P<0.05
High dose group 10 1000 165.74±18.24 P<0.05
Table 4 altitude sickness prevention soft capsule is to the influence of mice heat-resisting ability
Group Number of animals (only) Dosage (mg/kg) The high temperature time-to-live (min) The P value
Matched group 10 - 115.19±16.01 -
Low dose group 10 250 138.23±25.47 P>0.05
Middle dosage group 10 500 171.77±23.99 P<0.05
High dose group 10 1000 172.96±34.37 P<0.05
Cold-resistant and the high temperature resistant experiment of altitude sickness prevention soft capsule, after the mouse stomach administration, middle dosage, high dose group prolong the mice time-to-live, compare with matched group, have significant difference (P<0.05), and low dose group does not have significant change (P>0.05).The result shows the altitude sickness prevention soft capsule in range of doses, can significantly improve the cold-resistant and heat-resisting ability of mice.
4. altitude sickness prevention soft capsule resisting fatigue experiment
The mice of the same raising (male and female half and half), grouping and medication are the same.Successive administration 7 days, after the last administration 30 minutes, take by weighing body weight respectively before the animals administer and after the last administration, the mice body weight 5% of bearing a heavy burden respectively is put in 25 ℃ of water temperatures swimming grooves and swims, record mice power exhausts swimming time (sink under water be as the criterion in 10 seconds with mice), and experimental result sees Table 5
Table 5 altitude sickness prevention soft capsule is to the influence of mouse anti-reflecting fatigue ability
Group Number of animals (only) Dosage (mg/kg) Mice swimming time (min) The P value
Matched group 10 - 12.15±6.23 -
Low dose group 10 250 21.97±10.35 P<0.05
Middle dosage group 10 500 23.57±12.59 P<0.01
High dose group 10 1000 23.61±12.54 P<0.01
Mouse stomach gives the altitude sickness prevention soft capsule can obviously prolong the mice swimming with a load attached to the body time, compare with the normal saline matched group, there were significant differences for low dose group (P<0.05), middle and high dosage group has utmost point significant difference (P<0.01), and the result shows that the altitude sickness prevention soft capsule has the obvious anti-fatigue effect.
Above experimental data shows that the altitude sickness prevention soft capsule has tangible normal pressure in range of doses and reduce pressure anti-hypoxia, cold-resistant and high temperature resistant, antifatigue effect, can effectively improve the symptom of altitude sickness, for having very big value in highlands tourism and work crowd.Altitude sickness prevention soft capsule adult suggestion dose: specification 0.5g/ grain, warm water takes, every day 2 times, each 2.

Claims (9)

1. the soft capsule of an altitude sickness prevention, it is characterized in that its content is made of by a certain percentage vegetable oil, spirulina and suspending agent, wherein the percentage by weight of vegetable oil is 95%-5%, the percentage by weight of spirulina is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
2. altitude sickness prevention soft capsule according to claim 1 is characterized in that vegetable oil in the soft capsule is by in Princepia utilis oil, Camellia oil, olive oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil one or several.
3. altitude sickness prevention soft capsule according to claim 1; it is characterized in that described soft capsule can add Fructus Lycii; Fructus Mori; Radix Puerariae; Poria; Semen Ziziphi Spinosae; Rhizoma Dioscoreae; Fructus Jujubae; Herba Houttuyniae; Radix Rhodiolae; Folium Ginkgo; Radix Ginseng; Radix Panacis Quinquefolii; Ganoderma; Herb Gynostemmae Pentaphylli; Radix Et Caulis Acanthopanacis Senticosi; green tea; tea polyphenols; the Radix Astragali; Fructus Crataegi; pollen; Herba Cistanches; Semen Vitis viniferae extract; soybean phospholipid; Margarita powder; Colla Corii Asini; Lac regis apis; propolis; Squalene; Formica fusca; Cordyceps; the armillaria mellea extract; cattle colostrums; taurine; nucleic acid; melatonin; vitamin E; chitosan; the Sargassum polysaccharides sulfuric ester; in 1,6 fructose diphosphate one or several.
4. according to the described altitude sickness prevention soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 95%-5%, and the percentage by weight of spirulina is 4.5%-85%, and the percentage by weight of suspending agent is 0.5%-10%.
5. according to the described altitude sickness prevention soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 75%, spirulina percentage by weight 20%, and Cera Flava percentage by weight 5% is formed.
6. according to the described altitude sickness prevention soft capsule of claim 1, the content that it is characterized in that soft capsule is a Princepia utilis oil percentage by weight 45%, olive oil percentage by weight 40%, spirulina percentage by weight 10%, Cera Flava percentage by weight 4%, vitamin E percentage by weight 1%.
7. according to the described altitude sickness prevention soft capsule of claim 1, the content that it is characterized in that soft capsule is by Princepia utilis oil percentage by weight 75%, spirulina percentage by weight 15%, and green tea extract percentage by weight 5%, Cera Flava percentage by weight 5% is formed.
8. according to the described altitude sickness prevention soft capsule of claim 1, it is characterized in that soft capsule content is by Princepia utilis oil percentage by weight 55%, spirulina percentage by weight 30%, Radix Puerariae percentage by weight 5%, Semen Ziziphi Spinosae extract percentage by weight 5%, soybean phospholipid percentage by weight 5% is formed.
9. according to the described altitude sickness prevention soft capsule of claim 1, the content olive oil percentage by weight 40% that it is characterized in that soft capsule, Princepia utilis oil percentage by weight 10%, spirulina percentage by weight 20%, Radix Rhodiolae percentage by weight 10%, Folium Ginkgo percentage by weight 10%, Radix Panacis Quinquefolii percentage by weight 5%, Cera Flava percentage by weight 5%.
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CN104172165A (en) * 2014-08-15 2014-12-03 安徽和华生物医药科技有限公司 Squalene oil and coneflower soft capsule and preparation method thereof
CN104189099A (en) * 2014-06-17 2014-12-10 新疆医科大学 Application of cistanche phenylethanoid glycoside extractive to control altitude sickness
CN104382139A (en) * 2014-11-13 2015-03-04 黄琛 Beverage for treating acute alcoholism and production method thereof
CN105124594A (en) * 2015-06-26 2015-12-09 蚌埠市江淮粮油有限公司 Multi-nutrient anti-ageing rice-bran-oil microcapsule and preparation method thereof
CN107012057A (en) * 2017-06-05 2017-08-04 劲牌有限公司 A kind of resist oxygen lack health liquor and preparation method thereof
CN108030074A (en) * 2017-12-07 2018-05-15 石元刚 Improve complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof
CN108077936A (en) * 2017-11-16 2018-05-29 山西五台山沙棘制品有限公司 A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof
CN109315780A (en) * 2018-10-12 2019-02-12 深圳瑞达生物股份有限公司 Edible composition and its application
CN109892685A (en) * 2019-03-20 2019-06-18 福建绿色黄金生物科技有限公司 One grows tea and green bur leaf composition, preparation method and applications
CN112715896A (en) * 2020-12-31 2021-04-30 厦门思健生物科技有限公司 Compound propolis capsule and preparation method thereof
CN113854562A (en) * 2021-08-20 2021-12-31 新疆大德恒生物股份有限公司 Soft capsule of sweet almond oil and preparation method

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CN101715984B (en) * 2009-11-25 2013-03-20 天津天狮生物发展有限公司 Spirulina capsule and manufacturing process thereof
CN102716173A (en) * 2011-03-29 2012-10-10 赵军 Rapid anoxia-relieving capsule, preparation formula and preparation method thereof
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CN104000181A (en) * 2013-02-27 2014-08-27 北京宝德润生医药科技发展有限公司 Composition for relieving physical fatigue and preparation method thereof
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CN103478522A (en) * 2013-08-21 2014-01-01 山东福胶集团有限公司 Donkey-hide gelatin and propolis soft capsules and preparation method thereof
CN103829245A (en) * 2014-03-13 2014-06-04 太原纠偏食品开发有限公司 Rectification food for down regulating altitude stress and preparation method of rectification food
CN103829245B (en) * 2014-03-13 2016-02-17 太原纠偏食品开发有限公司 A kind of rectification food downgrading altitude sickness and preparation method thereof
CN103948896A (en) * 2014-05-13 2014-07-30 于法周 Composition for resisting altitude stress and application of composition
CN104189099A (en) * 2014-06-17 2014-12-10 新疆医科大学 Application of cistanche phenylethanoid glycoside extractive to control altitude sickness
CN104172165A (en) * 2014-08-15 2014-12-03 安徽和华生物医药科技有限公司 Squalene oil and coneflower soft capsule and preparation method thereof
CN104172165B (en) * 2014-08-15 2016-03-16 安徽和华生物医药科技有限公司 A kind of squalene oil Echinacea soft capsule and preparation method
CN104382139A (en) * 2014-11-13 2015-03-04 黄琛 Beverage for treating acute alcoholism and production method thereof
CN104382139B (en) * 2014-11-13 2016-05-18 黄琛 A kind of beverage for acute alcoholism and preparation method thereof
CN105124594A (en) * 2015-06-26 2015-12-09 蚌埠市江淮粮油有限公司 Multi-nutrient anti-ageing rice-bran-oil microcapsule and preparation method thereof
CN107012057A (en) * 2017-06-05 2017-08-04 劲牌有限公司 A kind of resist oxygen lack health liquor and preparation method thereof
CN108077936A (en) * 2017-11-16 2018-05-29 山西五台山沙棘制品有限公司 A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof
CN108030074A (en) * 2017-12-07 2018-05-15 石元刚 Improve complex nutrient preparation of plateau lower oxygen concentration resistance adaptability and preparation method thereof
CN109315780A (en) * 2018-10-12 2019-02-12 深圳瑞达生物股份有限公司 Edible composition and its application
CN109892685A (en) * 2019-03-20 2019-06-18 福建绿色黄金生物科技有限公司 One grows tea and green bur leaf composition, preparation method and applications
CN112715896A (en) * 2020-12-31 2021-04-30 厦门思健生物科技有限公司 Compound propolis capsule and preparation method thereof
CN113854562A (en) * 2021-08-20 2021-12-31 新疆大德恒生物股份有限公司 Soft capsule of sweet almond oil and preparation method

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