CN108096418A - A kind of preparation method of American Ginseng Gingkocapsule - Google Patents
A kind of preparation method of American Ginseng Gingkocapsule Download PDFInfo
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- CN108096418A CN108096418A CN201711394472.XA CN201711394472A CN108096418A CN 108096418 A CN108096418 A CN 108096418A CN 201711394472 A CN201711394472 A CN 201711394472A CN 108096418 A CN108096418 A CN 108096418A
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- american ginseng
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- ginkgo
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Classifications
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a kind of formulas of American Ginseng Gingkocapsule, are related to medicines and health protection food technology field, containing following component：250 350 parts by weight of ginkgo biloba extract, 100 200 parts by weight of American ginseng extract, 10 20 parts by weight of pilose antler, 10 30 parts by weight of Chinese yam, 58 parts by weight of 5 15 parts by weight of Herba Epimedii, 5 10 parts by weight of Cortex Eucommiae and starch.In addition, the preparation method the invention also discloses the American Ginseng Gingkocapsule.The American Ginseng Gingkocapsule of the present invention, supplementary material have collaboration enhancement effect, there is the effect of tonifying kidney and strengthening yang, and the American Ginseng Gingkocapsule of the long-term use of present invention has the effect of prevention kidney deficiency, and whole collinear processing, avoids nutrition leak caused by destabilizing factor.
Description
Technical field
The present invention relates to medicines and health protection food technology fields, and in particular to a kind of preparation method of American Ginseng Gingkocapsule.
Background technology
Kidney deficiency refers to kidney vital essence negative and positive deficiency.The species of kidney deficiency has very much, and one of the most common is kidney-yin deficiency, kidney-yang deficiency.
The symptom of kidney deficiency：The symptom of kidney-yang deficiency is the soreness of waist, coldness of extremities, chilly or even also oedema, is the symptom of " cold ", sexual function
It is bad to also result in kidney-yang deficiency；The symptom of kidney-yin deficiency is " heat ", mainly there is the soreness of waist, scorching, night sweat, abnormal sweating, dizziness, tinnitus etc..
Modern science proves, when human hair gives birth to kidney deficiency, no matter kidney-yin deficiency or kidney-yang deficiency, can all cause the reduction of the immunocompetence of people,
When having more evidences to show that kidney deficiency occurs, the immunocompetence of kidney reduces, and the microcirculqtory system of kidney can also hinder
Plug, kidney network present obstructed.So should prevent combination for the treatment of kidney deficiency, kidney tonifying is a severe problem.
Chinese Patent Application No. 201710666321.9 discloses a kind of anti-apolexis composition, purposes and guarantor made from it
Strong product, the composition include the raw material of following mass fraction：The coix seed of 4%-87%, the mulberries of 1%-84%, 1%-
84% matrimony vine, the pawpaw of 1%-84%, the gynostemma pentaphylla of 1%-84%, 0%-84% auxiliary materials.Said composition invigorating the spleen excreting dampness, kidney tonifying
Enriching yin contains the various nutrients of cell metabolism needs, has senile-resistant efficacy, and nutritional ingredient is more comprehensively more closed
It fits, safe and reliable, effect is notable.But effect is more, without specificity, in order to avoid effect is not achieved.
Chinese Patent Application No. 201710468297.8 discloses a kind of preparation method of the health products of tonifying kidney and strengthening yang, weighs
Sucrose, agate card, radix scrophulariae, pilose antler, Moschus, amber, Radix Glycyrrhizae, ginkgo leaf, donkey-hide gelatin, the root bark of Chinese wolf-berry, sealwort, Rhizoma Chuanxiong, Radix Angelicae Sinensis, dandelion and
Talcum powder；The principle of tcm treatment according to syndrome differentiation is followed, each taste medicine is formulated and complements each other, there is the effect of apparent tonifying kidney and strengthening yang, glue
Capsule by content and air exclusion, prevents content active ingredient from aoxidizing and losing effect or pollution by totally enclosed form,
The poor taste of raw material is covered simultaneously, is easily absorbed, enhances stability, and curative effect is ensured；Warming and invigorating kidney Yang, replenishing essence are enriched blood, Xing Yang
Impotence is played, after male patient takes, energetic, love life time lengthening, after female patient is taken, of pink and healthy-looking, facial expression shines
Hair, love life are harmonious；It keeps fit and healthy simultaneously, promote sleep；Synergistic effect is generated in prescription between each component, so as to band
Come, tonifying kidney and strengthening yang, gas essence filling, keep fit and healthy, promote longevity and other effects effect, but equally exists drawbacks described above.
The content of the invention
It is an object of the invention to provide a kind of preparation method of American Ginseng Gingkocapsule, to solve to cause in the prior art
Drawbacks described above.
The present invention is achieved through the following technical solutions, a kind of formula of American Ginseng Gingkocapsule, by weight, bag
It includes：
Preferably, a kind of formula of American Ginseng Gingkocapsule, by weight, including：
A kind of preparation method of American Ginseng Gingkocapsule, includes the following steps：
(1) take meet the related request of company standard through examine qualified ginkgo, American Ginseng, pilose antler, Chinese yam, Herba Epimedii,
Supplementary material is removed outer packing by Cortex Eucommiae and starch, and inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology silver-colored
American Ginseng is obtained Radix Salviae Miltiorrhizae by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology and extracted by apricot leaf extract
Object；
(3) crush, sieve：Pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae are cleaned pulverize and sieve it is spare；
(4) weigh：Ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae are weighed by formula rate
And starch is spare；
(5) one is mixed：By load weighted ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae
With multidirectional three-dimensional motion mixer mixing 80-100min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 25-35min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 1g-1.5g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Preferably, clean area humiture described in the step (1) is respectively 35 DEG C -40 DEG C, and 40%.
Preferably, the complex enzyme method for pretreating step in the step (2) is as follows：
(1) by drying at 55 DEG C of ginkgo, crush after 60 mesh sieves, spare at 2 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo, when enzymolysis time 5 is small, 50 DEG C of hydrolysis temperature, enzymolysis
PH4.5 obtains ginkgo enzymolysis liquid；
(3) by ginkgo enzymolysis liquid with 20% alcohol reflux extract 4 times, every time 2 it is small when, merge extracting solution, be concentrated into no alcohol
Taste adds water to adjust；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, at the beginning of obtaining ginkgo
Extract.
Preferably, the homogenate extraction method step in the step (2) is as follows：
(1) qualified American Ginseng will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 15000-17000r/min, extraction time 30s-50s are opened；
(3) filter, merge extract and obtain American Ginseng just extract.
Preferably, the dense technical step of negative pressure low temperature is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or American Ginseng is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 55-65 DEG C, concentration vacuum degree is 0.06-
When 0.08MPa, concentration time 2.5-3.5 are small；
(3) extract quality fraction is concentrated into as 2.5%.
Preferably, the spray technique step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 180-220 DEG C, unlatching centrifuges
Nozzle adds in the first extract of ginkgo or the first extract of American Ginseng that mass fraction is 2.5%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or American ginseng extract.
Preferably, the complex enzyme is cellulase and pectase, and the ratio of cellulase and pectase is 2:3.
Using above technical scheme, compared with prior art, the present invention has the following advantages：
Ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae have collaboration enhancement effect, there is benefit
The effect of kidney and enhancing body, the American Ginseng Gingkocapsule of the long-term use of present invention have the effect of prevention kidney deficiency, and whole collinear place
Reason, avoids nutrition leak caused by destabilizing factor；The ginkgo biloba p.e, American ginseng extract are located in advance by complex enzyme
Logos, the extraction of homogenate extraction method, can effectively ensure that the active principle Total Ginkgo Flavone-Glycoides, ginkgo lactones and west of ginkgo and American Ginseng
To highest, loss is minimized American ginseng total saposins extraction rate reached；Entire preparation process completes in certain clean area, ensure that
The cleaning of working environment reduces influence of the environment to capsule to the greatest extent.
Specific embodiment
Technical means, creative features, achievable purpose and effectiveness to make the present invention are easy to understand, with reference to specific
Embodiment, the present invention is further explained.
Embodiment 1
A kind of formula of American Ginseng Gingkocapsule, by weight：
Embodiment 2
A kind of formula of American Ginseng Gingkocapsule, by weight：
Embodiment 3
A kind of formula of American Ginseng Gingkocapsule, by weight：
Embodiment 4
A kind of formula of American Ginseng Gingkocapsule, by weight：
Embodiment 5
A kind of formula of American Ginseng Gingkocapsule, by weight：
It is worth noting that, in embodiment 1-5, the preparation method of making American Ginseng Gingkocapsule described above, bag
Include following steps：
(1) take meet the related request of company standard through examine qualified ginkgo, American Ginseng, pilose antler, Chinese yam, Herba Epimedii,
Supplementary material is removed outer packing by Cortex Eucommiae and starch, and inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology silver-colored
American Ginseng is obtained Radix Salviae Miltiorrhizae by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology and extracted by apricot leaf extract
Object；
(3) crush, sieve：Pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae are cleaned pulverize and sieve it is spare；
(4) weigh：Ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae are weighed by formula rate
And starch is spare；
(5) one is mixed：By load weighted ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae
With multidirectional three-dimensional motion mixer mixing 90min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 30min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 1g-1.5g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Clean area humiture described in the step (1) is respectively 35 DEG C, and 40%.Complex enzyme in the step (2) is pre-
Facture step is as follows：
(1) by drying at 55 DEG C of ginkgo, crush after 60 mesh sieves, spare at 2 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo, when enzymolysis time 5 is small, 50 DEG C of hydrolysis temperature, enzymolysis
PH4.5 obtains ginkgo enzymolysis liquid；
(3) by ginkgo enzymolysis liquid with 20% alcohol reflux extract 4 times, every time 2 it is small when, merge extracting solution, be concentrated into no alcohol
Taste adds water to adjust；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, at the beginning of obtaining ginkgo
Extract.
Homogenate extraction method step in the step (2) is as follows：
(1) qualified American Ginseng will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 15000r/min, extraction time 30s are opened；
(3) filter, merge extract and obtain American Ginseng just extract.
The dense technical step of negative pressure low temperature is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or American Ginseng is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 55 DEG C, concentration vacuum degree is 0.08MPa, concentration when
Between 2.5 it is small when；
(3) extract quality fraction is concentrated into as 2.5%.
The spray technique step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 220 DEG C, opens centrifugal energy nozzle,
Add in the first extract of ginkgo or the first extract of American Ginseng that mass fraction is 2.5%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or American ginseng extract.
The complex enzyme is cellulase and pectase, and the ratio of cellulase and pectase is 2:3.
Acute toxicity test in mice：
Using maximum tolerated dose method, the Kunming mouse 20 that weight is 18-22g, half male and half female are selected.Take the present invention
American Ginseng Gingkocapsule content 50g adds 1% sodium carboxymethylcellulose to 100mL.To oral when interval 4 is small in mouse one day
Gavage 2 times, each gavage volume are 0.2mL/10g.bw, intergal dose 20.00g/kg.bw.Fasting 16 is small before gavage for the first time
When, it is observed continuously two weeks after gavage, records poisoning manifestations and death condition.Experimental result is as follows：
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is female | 10 | Orally | 20 | 0 | >20.00 |
| It is male | 10 | Orally | 20 | 0 | >20.00 |
With the American Ginseng Gingkocapsule content of the inventive samples of 20.00g/kg.bw dosage to the Kunming of two kinds of genders
Apparent poisoning symptom is had no after kind intragastric administration on mice, observes 14 days without death.Animal subject execution is carried out solution dissect by the observation end of term
It looks into, the main organs such as liver,spleen,kidney, stomach, intestines, the heart, lung show no obvious abnormalities change.Illustrate American Ginseng Gingkocapsule pair of the present invention
Kunming mouse male and female mouse maximal tolerance dose is more than 20.00g/kg.bw, belongs to nontoxic grade.
Effect experiment：
American Ginseng Gingkocapsule effect that embodiment 1-5 is produced is evaluated following with edible rear effect.Pass through 60
The volunteer of Patients with Kidney Deficiency Type is arbitrarily divided into 6 groups, eats American Ginseng ginkgo prepared by embodiment 1-5 respectively as object on probation
Capsule and blank control group once a day, are eaten one month, and effect total score is 5 points：5 points are best result, represent fine, non-
It is often satisfied；4 points are preferable；3 points are that can receive；Less than 3 points are bad, it is impossible to be received.It is below every average.
| Object | Therapeutic effect average |
| Embodiment 1 | 5 |
| Embodiment 2 | 4.8 |
| Embodiment 3 | 4.9 |
| Embodiment 4 | 4.7 |
| Embodiment 5 | 4.5 |
| Blank group | 1.8 |
In conclusion there is collaboration to promote for ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae
Effect has the effect of tonifying kidney and strengthening yang, and the American Ginseng Gingkocapsule of the long-term use of present invention has the effect of prevention kidney deficiency, and complete
Processing that journey is collinear, avoids nutrition leak caused by destabilizing factor；The ginkgo biloba p.e, American ginseng extract pass through multiple
Synthase method for pretreating, the extraction of homogenate extraction method, can effectively ensure that active principle Total Ginkgo Flavone-Glycoides, the ginkgo of ginkgo and American Ginseng
To highest, loss is minimized for lactones and American ginseng total saponins extraction rate reached；Entire preparation process is complete in certain clean area
Into ensure that the cleaning of working environment, reduce influence of the environment to capsule to the greatest extent.
As known by the technical knowledge, the present invention can pass through the embodiment party of other essence without departing from its spirit or essential feature
Case is realized.Therefore, embodiment disclosed above, all things considered are all merely illustrative, not the only.Institute
Have within the scope of the present invention or be included in the invention in the change being equal in the scope of the present invention.
Claims (9)
1. a kind of formula of American Ginseng Gingkocapsule, which is characterized in that by weight, including：
。
2. a kind of formula of American Ginseng Gingkocapsule according to claim 1, which is characterized in that by weight, including：
。
3. according to the preparation method of claim 1-2 any one of them American Ginseng Gingkocapsules, which is characterized in that including as follows
Step：
(1) related request for meeting company standard is taken through examining qualified ginkgo, American Ginseng, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae
And supplementary material is removed outer packing by starch, inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained into ginkgo leaf by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology
American Ginseng is obtained Salvia root P.E by extract by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology；
(3) crush, sieve：Pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae are cleaned pulverize and sieve it is spare；
(4) weigh：By formula rate weigh ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii, Cortex Eucommiae and
Starch is spare；
(5) one is mixed：Load weighted ginkgo biloba p.e, American ginseng extract, pilose antler, Chinese yam, Herba Epimedii and Cortex Eucommiae are used more
To three-dimensional motion mixer mixing 80-100min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 25-35min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 1g-1.5g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
4. a kind of preparation method of American Ginseng Gingkocapsule according to claim 3, it is characterised in that：The step (1)
Described in clean area humiture be respectively 35 DEG C -40 DEG C, 40%.
5. a kind of preparation method of American Ginseng Gingkocapsule according to claim 3, it is characterised in that：The step (2)
In complex enzyme method for pretreating step it is as follows：
(1) by drying at 55 DEG C of ginkgo, crush after 60 mesh sieves, spare at 2 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo, and when enzymolysis time 5 is small, 50 DEG C of hydrolysis temperature digests pH4.5, obtains
Ginkgo enzymolysis liquid；
(3) by ginkgo enzymolysis liquid with 20% alcohol reflux extract 4 times, every time 2 it is small when, merge extracting solution, be concentrated into no alcohol taste, add
Water adjusts；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, obtained ginkgo and just carry
Object.
6. a kind of preparation method of American Ginseng Gingkocapsule according to claim 3, it is characterised in that：The step (2)
In homogenate extraction method step it is as follows：
(1) qualified American Ginseng will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 15000-17000r/min, extraction time 30s-50s are opened；
(3) filter, merge extract and obtain American Ginseng just extract.
7. a kind of preparation method of American Ginseng Gingkocapsule according to claim 3, it is characterised in that：The negative pressure low temperature
Dense technical step is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or American Ginseng is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 55-65 DEG C, concentration vacuum degree is 0.06-0.08MPa, dense
When contracting time 2.5-3.5 is small；
(3) extract quality fraction is concentrated into as 2.5%.
8. a kind of preparation method of American Ginseng Gingkocapsule according to claim 3, it is characterised in that：The spray technique
Step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 180-220 DEG C, opens centrifugal energy nozzle,
Add in the first extract of ginkgo or the first extract of American Ginseng that mass fraction is 2.5%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or American ginseng extract.
9. a kind of preparation method of American Ginseng Gingkocapsule according to claim 5, it is characterised in that：The complex enzyme is
The ratio of cellulase and pectase, cellulase and pectase is 2:3.
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| CN114209056A (en) * | 2021-12-22 | 2022-03-22 | 聂永志 | American ginseng and cervus elaphus linnaeus capsules |
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| CN107242561A (en) * | 2017-02-24 | 2017-10-13 | 北京众康生物科技有限公司 | A kind of saussurea involucrata American Ginseng cervus elaphus linnaeus capsule and preparation method thereof |
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