CN108066645A - A kind of preparation method of ginkgo leaf capsule of red sage root - Google Patents
A kind of preparation method of ginkgo leaf capsule of red sage root Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of formulas of ginkgo leaf capsule of red sage root, are related to medicines and health protection food technology field, containing following component：200 300 parts by weight of ginkgo biloba p.e, 150 200 parts by weight of Salvia root P.E, 8 15 parts by weight of 15 20 parts by weight of caulis bambusae in taenian, 12 25 parts by weight of reddish brown powder and starch.In addition, the preparation method the invention also discloses the ginkgo leaf capsule of red sage root.The ginkgo leaf capsule of red sage root of the present invention, there is stable coronary disease and angina pectoris symptom, and the ginkgo leaf capsule of red sage root of the long-term use of present invention has the effect of prevention coronary heart disease, and whole collinear processing, avoids nutrition leak caused by destabilizing factor.
Description
Technical field
The present invention relates to medicines and health protection food technology fields, and in particular to a kind of preparation method of ginkgo leaf capsule of red sage root.
Background technology
" coronary heart disease " is the abbreviation of coronary cardiopathy, and heart is the vitals of human body, its effect like
It is a pump being never stopped, conveys the blood flow for carrying oxygen and nutriment through sustainer as heart is shunk every time
To whole body, cell metabolism needs are knitted to supply each group.Since lipid-metabolism is abnormal, the lipid calmness in blood is in otherwise smooth
Endarterium on, endarterium some similar to athero- lipid material accumulation into white patch, be known as Atherosclerosis
Change lesion.These patches increase gradually causes lumen of artery narrow, and blood flow is made to be obstructed, and causes heart ischemia, generates angina pectoris.If
Patch on arterial wall forms ulcer or rupture, will form thrombus, entire vascular flow is made to interrupt completely, and Acute myocardial occurs
Infarct or even sudden death.The rare pathogenesis of coronary heart disease is coronarospasm (blood vessel can not have atherosis), generates change
Different in nature angina pectoris, if spasm more than 30 minutes, also results in acute myocardial infarction AMI (or even sudden death).Therefore research prevention coronary disease
The effective ways of disease have become a severe publilc health problem.
Chinese Patent Application No. 201710500552.2 discloses a kind of health-care food for assisting blood fat lowering and preparation method thereof,
Health-care food for assisting blood fat lowering, including capsule and the filler material that is filled in the capsule, filler material by following parts by weight original
Material is made：5-20 parts of 20-80 parts of freeze dry powder of fermented soybean, 5-20 parts of ginkgo biloba p.e, 10-40 parts of chitosan and taurine；Its
In, the weight ratio of freeze dry powder of fermented soybean and ginkgo biloba p.e is 5-10：1.The inventive point of the present invention is：Only freezed by natto
These four raw materials of powder, ginkgo biloba p.e, chitosan and taurine are made according to said ratio, and freeze dry powder of fermented soybean and ginkgo
The weight ratio of leaf extract is necessary for 5-10:1, only meet above-mentioned condition, the health food of the invention can possess effectively
Hypolipemic function.The preparation method of the present invention, it is not only simple for process, and also the health food being prepared has significant drop blood
Fat effect.But the effect of risen, does not have specificity.
Chinese Patent Application No. 201611242777.4 disclose a kind of drug of prevention and treatment of coronary heart disease and preparation method thereof with
Using the drug is ginseng and the extract of Radix Salviae Miltiorrhizae, and main component includes ginsenoside, sugar wherein in ginseng and Salvia root P.E
Class, root of red-rooted salvia phenolic acid, amino acid and protein ingredient；Tablet capsule agent, granule, pill, inhalant etc. can be prepared into；The medicine
Object can be obviously improved particularly for merging the application in Lower cardiac function medicine to coronary heart disease with qi deficiency and blood stasis or coronary heart disease
Lower cardiac function symptom caused by coronary heart disease using theory of traditional Chinese medical science diagnosis and treatment principle, analyses in depth the essence that its " card " occurs,
Simultaneously avoid currently on the market drug there are the defects of, be coronary heart disease, especially have both the treatment of Lower cardiac function, bring one
The new therapeutic choice of kind, has relatively well made up the market space.But people contradict drug psychology, and pre- preventive effect is probably not achieved
Fruit.
The content of the invention
It is an object of the invention to provide a kind of preparation method of ginkgo leaf capsule of red sage root, to solve to cause in the prior art
Drawbacks described above.
The present invention is achieved through the following technical solutions, a kind of formula of ginkgo leaf capsule of red sage root, by weight, bag
It includes：
Preferably, a kind of formula of ginkgo leaf capsule of red sage root, by weight, including：
A kind of preparation method of ginkgo leaf capsule of red sage root, includes the following steps：
(1) related request for meeting company standard is taken through examining qualified ginkgo leaf, Radix Salviae Miltiorrhizae, caulis bambusae in taenian, reddish brown powder and starch
Supplementary material is removed into outer packing, inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology silver-colored
Radix Salviae Miltiorrhizae is obtained Salvia root P.E by apricot leaf extract by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology；
(3) crush, sieve：Caulis bambusae in taenian, reddish brown powder are pulverized and sieved spare；
(4) weigh：It is spare that ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, reddish brown powder and starch are weighed by formula rate；
(5) one is mixed：Load weighted ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, the multidirectional three-dimensional motion of reddish brown powder are mixed
Machine mixing 60-70min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 20-35min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 0.8g-1g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Preferably, clean area humiture described in the step (1) is respectively 20 DEG C -30 DEG C, and 45%.
Preferably, the complex enzyme method for pretreating step in the step (2) is as follows：
(1) by drying at 60 DEG C of ginkgo leaf, crush after 40 mesh sieves, spare at 4 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo leaf, when enzymolysis time 3 is small, 40 DEG C of hydrolysis temperature, enzymolysis
PH4.0 obtains ginkgo leaf enzymolysis liquid；
(3) by ginkgo leaf enzymolysis liquid with 20% alcohol reflux extract 3 times, every time 2 it is small when, merge extracting solution, be concentrated into nothing
Alcohol taste adds water to adjust；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, at the beginning of obtaining ginkgo
Extract.
Preferably, the homogenate extraction method step in the step (2) is as follows：
(1) qualified Radix Salviae Miltiorrhizae will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 10000-12000r/min, extraction time 30s-1min are opened；
(3) filter, merge extract and obtain Radix Salviae Miltiorrhizae just extract.
Preferably, the dense technical step of negative pressure low temperature is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or Radix Salviae Miltiorrhizae is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 50-60 DEG C, concentration vacuum degree is 0.06-
When 0.08MPa, concentration time 2-3 are small；
(3) extract quality fraction is concentrated into as 2%.
Preferably, the spray technique step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 180-220 DEG C, unlatching centrifuges
Nozzle adds in the first extract of ginkgo or the first extract of Radix Salviae Miltiorrhizae that mass fraction is 2%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or Salvia root P.E.
Preferably, the complex enzyme is cellulase and pectase, and the ratio of cellulase and pectase is 1:1.
Using above technical scheme, compared with prior art, the present invention has the following advantages：
Ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian and reddish brown powder have collaboration enhancement effect, have the stable coronary heart disease heart to twist
Pain symptom, the ginkgo leaf capsule of red sage root of the long-term use of present invention have the effect of prevention coronary heart disease, and whole collinear processing, keep away
Nutrition leak caused by having exempted from destabilizing factor；The ginkgo biloba p.e, Salvia root P.E pass through complex enzyme method for pretreating, sudden strain of a muscle
Formula extraction method is extracted, and can effectively ensure that the active principle Total Ginkgo Flavone-Glycoides, ginkgo lactones and tanshinone, Yin Dan of ginkgo and Radix Salviae Miltiorrhizae
Join ketone, isotanshinone, miltionone, tanshinol extraction rate reached to highest, loss is minimized；Entire preparation process is certain
It is completed in clean area, ensure that the cleaning of working environment, reduce influence of the environment to capsule to the greatest extent.
Specific embodiment
Technical means, creative features, achievable purpose and effectiveness to make the present invention are easy to understand, with reference to specific
Embodiment, the present invention is further explained.
Embodiment 1
A kind of formula of ginkgo leaf capsule of red sage root, by weight：
Embodiment 2
A kind of formula of ginkgo leaf capsule of red sage root, by weight：
Embodiment 3
A kind of formula of ginkgo leaf capsule of red sage root, by weight：
Embodiment 4
A kind of formula of ginkgo leaf capsule of red sage root, by weight：
Embodiment 5
A kind of formula of ginkgo leaf capsule of red sage root, by weight：
It is worth noting that, in embodiment 1-5, the preparation method of making ginkgo leaf capsule of red sage root described above, bag
Include following steps：
(1) related request for meeting company standard is taken through examining qualified ginkgo leaf, Radix Salviae Miltiorrhizae, caulis bambusae in taenian, reddish brown powder and starch
Supplementary material is removed into outer packing, inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology silver-colored
Radix Salviae Miltiorrhizae is obtained Salvia root P.E by apricot leaf extract by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology；
(3) crush, sieve：Caulis bambusae in taenian, reddish brown powder are pulverized and sieved spare；
(4) weigh：It is spare that ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, reddish brown powder and starch are weighed by formula rate；
(5) one is mixed：Load weighted ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, the multidirectional three-dimensional motion of reddish brown powder are mixed
Machine mixing 65min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 30min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 1g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Furthermore it is noted that clean area humiture described in the step (1) is respectively 28 DEG C, 45%.The step
Suddenly the complex enzyme method for pretreating step in (2) is as follows：
(1) by drying at 60 DEG C of ginkgo leaf, crush after 40 mesh sieves, spare at 4 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo leaf, when enzymolysis time 3 is small, 40 DEG C of hydrolysis temperature, enzymolysis
PH4.0 obtains ginkgo leaf enzymolysis liquid；
(3) by ginkgo leaf enzymolysis liquid with 20% alcohol reflux extract 3 times, every time 2 it is small when, merge extracting solution, be concentrated into nothing
Alcohol taste adds water to adjust；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, at the beginning of obtaining ginkgo
Extract.
Homogenate extraction method step in the step (2) is as follows：
(1) qualified Radix Salviae Miltiorrhizae will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 10000r/min, extraction time 30s are opened；
(3) filter, merge extract and obtain Radix Salviae Miltiorrhizae just extract.
The dense technical step of negative pressure low temperature is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or Radix Salviae Miltiorrhizae is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 55 DEG C, concentration vacuum degree is 0.07MPa, concentration when
Between 2 it is small when；
(3) extract quality fraction is concentrated into as 2%.
The spray technique step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 220 DEG C, opens centrifugal energy nozzle,
Add in the first extract of ginkgo or the first extract of Radix Salviae Miltiorrhizae that mass fraction is 2%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or Salvia root P.E.
The complex enzyme is cellulase and pectase, and the ratio of cellulase and pectase is 1:1.
Acute toxicity test in mice：
Using maximum tolerated dose method, the Kunming mouse 20 that weight is 18-22g, half male and half female are selected.Take the present invention
Ginkgo leaf capsule of red sage root content 50g adds 1% sodium carboxymethylcellulose to 100mL.To oral when interval 4 is small in mouse one day
Gavage 2 times, each gavage volume are 0.2mL/10g.bw, intergal dose 20.00g/kg.bw.Fasting 16 is small before gavage for the first time
When, it is observed continuously two weeks after gavage, records poisoning manifestations and death condition.Experimental result is as follows：
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is female | 10 | Orally | 20 | 0 | >20.00 |
| It is male | 10 | Orally | 20 | 0 | >20.00 |
With the ginkgo leaf capsule of red sage root content of the inventive samples of 20.00g/kg.bw dosage to the Kunming of two kinds of genders
Apparent poisoning symptom is had no after kind intragastric administration on mice, observes 14 days without death.Animal subject execution is carried out solution dissect by the observation end of term
It looks into, the main organs such as liver,spleen,kidney, stomach, intestines, the heart, lung show no obvious abnormalities change.Illustrate ginkgo leaf capsule of red sage root pair of the present invention
Kunming mouse male and female mouse maximal tolerance dose is more than 20.00g/kg.bw, belongs to nontoxic grade.
Effect experiment
Ginkgo leaf capsule of red sage root effect that embodiment 1-5 is produced is evaluated following with edible rear effect.Pass through 60
The volunteer of patients with coronary heart disease is arbitrarily divided into 6 groups, it is red to eat ginkgo leaf prepared by embodiment 1-5 respectively as object on probation
Ginseng capsule and blank control group once a day, are eaten one month, and effect total score is 5 points：5 points are best result, represent fine,
It is very satisfied；4 points are preferable；3 points are that can receive；Less than 3 points are bad, it is impossible to be received.It is below every average.
In conclusion the ginkgo leaf capsule of red sage root of the present invention, ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian and reddish brown powder
With collaboration enhancement effect, there is stable coronary disease and angina pectoris symptom, the ginkgo leaf capsule of red sage root of the long-term use of present invention has prevention
The effect of coronary heart disease, and whole collinear processing, avoid nutrition leak caused by destabilizing factor；The ginkgo leaf extraction
Object, Salvia root P.E are extracted by complex enzyme method for pretreating, homogenate extraction method, can effectively ensure that the working substance of ginkgo and Radix Salviae Miltiorrhizae
Matter Total Ginkgo Flavone-Glycoides, ginkgo lactones and tanshinone, Cryptotanshinone, isotanshinone, miltionone, tanshinol extraction rate reached are to most
Height, loss are minimized；Entire preparation process completes in certain clean area, ensure that the cleaning of working environment, maximum journey
Influence of the reduction environment of degree to capsule.
As known by the technical knowledge, the present invention can pass through the embodiment party of other essence without departing from its spirit or essential feature
Case is realized.Therefore, embodiment disclosed above, all things considered are all merely illustrative, not the only.Institute
Have within the scope of the present invention or be included in the invention in the change being equal in the scope of the present invention.
Claims (9)
1. a kind of formula of ginkgo leaf capsule of red sage root, which is characterized in that by weight, including：
2. a kind of formula of ginkgo leaf capsule of red sage root according to claim 1, which is characterized in that by weight, including：
3. according to the preparation method of claim 1-2 any one of them ginkgo leaf capsule of red sage root, which is characterized in that including as follows
Step：
(1) related request for meeting company standard is taken through examining qualified ginkgo leaf, Radix Salviae Miltiorrhizae, caulis bambusae in taenian, reddish brown powder and starch by original
Auxiliary material removes outer packing, and inner packing is by entering clean area between buffering；
(2) extract：Ginkgo is obtained into ginkgo leaf by complex enzyme method for pretreating, negative pressure low temperature concentration technique and spray drying technology
Radix Salviae Miltiorrhizae is obtained Salvia root P.E by extract by homogenate extraction method, negative pressure low temperature concentration technique and spray drying technology；
(3) crush, sieve：Caulis bambusae in taenian, reddish brown powder are pulverized and sieved spare；
(4) weigh：It is spare that ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, reddish brown powder and starch are weighed by formula rate；
(5) one is mixed：Load weighted ginkgo biloba p.e, Salvia root P.E, caulis bambusae in taenian, reddish brown powder are mixed with multidirectional three-dimensional motion mixer
Close 60-70min；
(6) two is mixed：Step (4) mixed powder is added in into load weighted starch mixing 20-35min, obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 0.8g-1g/；
(8) polish, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
4. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 3, it is characterised in that：The step (1)
Described in clean area humiture be respectively 20 DEG C -30 DEG C, 45%.
5. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 3, it is characterised in that：The step (2)
In complex enzyme method for pretreating step it is as follows：
(1) by drying at 60 DEG C of ginkgo leaf, crush after 40 mesh sieves, spare at 4 DEG C；
(2) complex enzyme is added in, complex enzyme is the 1/300 of ginkgo leaf, and when enzymolysis time 3 is small, 40 DEG C of hydrolysis temperature digests pH4.0,
Obtain ginkgo leaf enzymolysis liquid；
(3) by ginkgo leaf enzymolysis liquid with 20% alcohol reflux extract 3 times, every time 2 it is small when, merge extracting solution, be concentrated into no alcohol taste,
Water is added to adjust；
(4) said extracted liquid is filtered to remove solid content, is purified using LX-5 type macroporous absorbent resins, obtained ginkgo and just carry
Object.
6. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 3, it is characterised in that：The step (2)
In homogenate extraction method step it is as follows：
(1) qualified Radix Salviae Miltiorrhizae will be examined to be put into flash extracter, adds in the aqueous solvent of 10 times of Radix Salviae Miltiorrhizae amount；
(2) power switch motor, speed of agitator 10000-12000r/min, extraction time 30s-1min are opened；
(3) filter, merge extract and obtain Radix Salviae Miltiorrhizae just extract.
7. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 3, it is characterised in that：The negative pressure low temperature
Dense technical step is as follows：
(1) extract at the beginning of extract at the beginning of ginkgo or Radix Salviae Miltiorrhizae is put into concentrator container；
(2) concentrator container is started, condition is：Thickening temperature is 50-60 DEG C, concentration vacuum degree is 0.06-0.08MPa, dense
When contracting time 2-3 is small；
(3) extract quality fraction is concentrated into as 2%.
8. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 3, it is characterised in that：The spray technique
Step is as follows：
(1) spray drying tower centrifugal blower is first turned on, when hothouse inlet temperature reaches 180-220 DEG C, opens centrifugal energy nozzle,
Add in the first extract of ginkgo or the first extract of Radix Salviae Miltiorrhizae that mass fraction is 2%；
(2) dried finished product is collected, and obtains ginkgo biloba p.e or Salvia root P.E.
9. a kind of preparation method of ginkgo leaf capsule of red sage root according to claim 5, it is characterised in that：The complex enzyme is
The ratio of cellulase and pectase, cellulase and pectase is 1:1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113287681A (en) * | 2021-03-15 | 2021-08-24 | 中国林业科学研究院林产化学工业研究所 | Method for preparing composite anti-feed additive by taking ginkgo leaf residue lipid extract as raw material |
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| CN1369289A (en) * | 2001-11-23 | 2002-09-18 | 曹柱 | Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process |
| CN1504208A (en) * | 2002-11-29 | 2004-06-16 | 张 永 | Gingko drop pill for prevention and treatment of cardiovascular and cerebrovascular disease |
| CN1562216A (en) * | 2004-04-07 | 2005-01-12 | 北京奇源益德药物研究所 | Preparation of Chinese traditional medicine for curing cardiovascular and cerebrovascular disease and preparation method |
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Application publication date: 20180525 |